Digital Commons Network^™

Atg16l1 Controls Mammalian Vacuolar Proton Atpase, Thabata L A Duque, Masroor Paddar, Einar Trosdal, Ruheena Javed, Lee Allers, Michal H Mudd, Prithvi Akepati, Soumya R Mishra, Michelle Salemi, Brett Phinney, Shawn B Bratton, Thomas Wileman, Vojo Deretic

Faculty, Staff and Student Publications

The mechanisms governing mammalian proton pump V-ATPase function are of fundamental and medical interest. The assembly and disassembly of cytoplasmic V1 domain with the membrane-embedded V0 domain of V-ATPase is a key aspect of V-ATPase localization and function. Here, we show that the mammalian protein ATG16L1, primarily appreciated for its role in canonical autophagy and in noncanonical membrane atg8ylation processes, controls V-ATPase. ATG16L1 knockout elevated V-ATPase activity, increased V1 presence on endomembranes, and increased the number of acidified intracellular compartments. ATG16L1's ability to efficiently bind V-ATPase was required for its inhibitory role in endolysosomal acidification and for control of Mycobacterium …

New Avenues In Childhood Vasculitis, Hulya Ercan Emreol, Cagri Yildirim-Toruner, Marija Jelusic, Marinka Twilt, Seza Ozen

Faculty, Staff and Students Publications

Childhood vasculitis encompasses a group of rare and heterogeneous diseases with systemic inflammation affecting various vessel sizes. This comprehensive review highlights recent advances in the pathogenesis, biomarkers, diagnosis, and treatment strategies for major pediatric vasculitides including IgA vasculitis, Kawasaki Disease, ANCA-associated vasculitis, Takayasu arteritis, and Polyarteritis Nodosa. Novel insights from genetic, immunologic, and imaging studies have paved the way for early diagnosis and individualized therapeutic approaches. Future directions emphasize the role of artificial intelligence, precision medicine, and international collaborative trials to optimize long-term outcomes and quality of life in affected children.

Apoe-Calypse Tau: Apoe-Tau Synergy In Alzheimer's Disease, Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D Ulrich, David M Holtzman, Maud Gratuze

2020-Current year OA Pubs

Alzheimer's disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. While much of the research has focused on Aβ, tau-mediated neurodegeneration is more closely associated with synaptic loss and cognitive decline in AD, emphasizing the need for a deeper understanding of tau pathology. In this context, the interaction between tau and APOE, particularly the main genetic risk factor for AD APOE ε4, remains underexplored. APOE encodes apolipoprotein E (apoE), a protein important in lipid metabolism. In addition to promoting Aβ deposition, emerging …

Ndls Communicator: Week Of 10.06.25, Notre Dame Law School

NDLS Communicator

The Latest News

• Faculty profile: Professor Mary Ellen O'Connell, globally influential scholar of international law and peace
• Panel explores Catholic Social Teaching and human rights in Africa

Faculty Briefs

• Nicole Garnett
• Sadie Blanchard
• Patrick Corrigan
• Roger Alford
• Mary Ellen O'Connell
• Christine Venter
• Paolo Carozza
• Avishalom Tor
• Emily Bremer
• Fr. John Paul Kimes
• Derek Muller
• Judy Fox
• Gerard Bradley

ND Law in the News

• Notre Dame Law School's partnership with Harvey AI was featured in a Law360 article.

Student News

• Third-year law student Dennis Weiboldt III wrote an article for First Things Magazine about the Red Mass

Events

• Law and Economics …

Understanding The Role Of Street Medicine In Harm Reduction: A Case Study Of Street Medicine St. Louis, Ari Gzesh, Jeremiah S Truel, Danielle R Adams, Luke Zabotka, Sara Malone, Nathanial S Nolan

2020-Current year OA Pubs

BACKGROUND: Homelessness results from, and exacerbates, various social determinants of health, including poverty, racism, and inadequate healthcare access, which are further compounded by physical and mental health challenges. The street medicine movement seeks to address these disparities by providing direct medical care and harm reduction services to unsheltered homeless in low-barrier settings. The development of trust is critical to providing this form of care. Few studies have sought to understand the factors influencing trust development in street medicine encounters.

METHODS: This case study of Street Medicine St. Louis aims to explore the factors that influence trust and how trust development …

Economic And Policy Drivers Of Climate-Smart Soil Health Practices In The United States, Roderick Rejesus, Serkan Aglasan, Lawson Connor

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Climate-smart soil health practices, such as cover crops and no-till, are considered to be key elements for climate change adaptation and mitigation in agriculture. We examine the empirical literature that provides data-driven evidence on the impact of cover crops and no-till on several economic variables of interest, such as yields, inputs, profits, risk, erosion, and water quality. In general, existing studies provide mixed evidence on the impacts of cover crops and no-till on these outcomes. Moreover, we discuss the empirical literature exploring the impact of economic and policy-related variables on adopting cover crops and no-till. We find that a number …

A Supplement, Not A Substitute: Accuracy And Completeness Of Chatgpt Responses For Common Elbow Pathology, Benjamin Fiedler, Umar Ghilzai, Abdullah Ghali, Phillip Goldman, Pablo Coello, Michael B Gottschalk, Eric R Wagner, Adil Shahzad Ahmed

Faculty, Staff and Students Publications

Hypothesis: Large language models (LLMs) like ChatGPT have increasingly been used as online resources for patients with orthopedic conditions. Yet there is a paucity of information assessing the ability of LLMs to accurately and completely answer patient questions. The present study comparatively assessed both ChatGPT 3.5 and GPT-4 responses to frequently asked questions on common elbow pathologies, scoring for accuracy and completeness. It was hypothesized that ChatGPT 3.5 and GPT-4 would demonstrate high levels of accuracy for the specific query asked, but some responses would lack completeness, and GPT-4 would yield more accurate and complete responses than ChatGPT 3.5.

Methods: …

The Taxonomy And Origins Of Folia: A Brief Review, Donald G. Davis, Louise D. Hose, Harvey R. Duchene

International Journal of Speleology

All folia demonstrate a few common elements: folia (singular, folium) are planar or sub-planar speleothems, slanting downward and away from cave walls and ceilings, and genetically associated with fluctuating environmental interfaces. They were first identified and named from examples in western USA hypogenic caves but have since been identified elsewhere in the world. Folia shelves are typically composed of calcite and interweave smoothly along sub-horizontal contours. Calcite accretion, both chemical and mechanical from suspended particles, follows water-surface fluctuations to form protrusions in arrays along walls and ceilings where new accretion tends to follow the water-surface downward during descending phases, gradually …

The Assessment Of Prosodic Writing Skills Among The Students Of The Arabic Language Bachelor Program In The Light Of The Variables Of Gender And Cumulative Average At King Khalid University, Fatimah Shaaban Asiri

University of Bisha Journal for Educational Sciences

The research aimed to identify the level of prosodic writing skills among the students of the Arabic language bachelor program. To achieve the objectives of the research, the descriptive approach was used. The researcher prepared a prosodic writing skills test. The research sample consisted of (187) male and female undergraduate students in the Arabic language major, males and females, at King Khalid University in its various branches. The results resulted in a list of (10) prosodic writing skills. The results showed that the percentage of mastery of students of the Arabic language program at King Khalid University in prosody writing …

A Proposed Training Program For Developing Reciprocal Teaching Skills For Secondary School English Language, Ahmad Atif Alshehri, Ahmed Awad Asiri

University of Bisha Journal for Educational Sciences

This research aims to prepare a proposed training program for devel-oping reciprocal teaching skills for secondary school English language teachers. To achieve this goal, the researcher prepared a list of recip-rocal teaching skills. In the light of this،, a questionnaire was prepared to identify the training needs of English language teachers at second-ary school and their level of the 315 English language teachers in the secondary school which affiliate to the department of education in Asseer Region. The researcher used the descriptive approach in pre-paring the research tool. The results of research resulted in a list of training needs in …

Level Of The Teaching Practices Promoting Collective Mathematical Argumentation In The Intermediate Stage Mathematics Classrooms, Ibrahim Alhussain Khalil

University of Bisha Journal for Educational Sciences

This study aimed to evaluate the teaching practices that promote collective mathematical argumentation in middle school mathematics classrooms. It adopted the descriptive method. The sample consisted of 24 teachers of mathematics in the middle-school stage in the Middle Education Office of the Bisha Education Directorate. Quantitative observation was used as a data collection tool, which consisted of 26 teaching practices divided into four categories. The study reached several results the most notable of which is that the level of teaching practices that promote mathematical argumentation in general amounted to (2.75 - 4.00) at an average level, in the following order: …

A Suggested Conception Of A Training Program Based On Mathematical Prowess Skills For Primary School Mathematics Teachers, Mohammed Barjas Alshahrani

University of Bisha Journal for Educational Sciences

The current research aims to build a proposed training program for the development of mathematical dexterity skills for primary school mathematics teachers, and to achieve the research objectives, a list of indicators was prepared to achieve the appropriate mathematical dexterity skills for the primary stage, which amounted to (15) indicators distributed over the five mathematical dexterity skills, and through the application of the search tool on Primary school teachers, where the sample amounted to 35 teachers, it was found that there is a great need for these needs, and in light of this, the proposed training program was prepared, and …

Teachers' Conceptions Of Mathematics Fluency And Teaching Practices That Support Creativity And Their Relationship To Teaching Efficiency, Metab Zazoo Al-Enezi

University of Bisha Journal for Educational Sciences

The study aimed to identify the correlation between mathematics teachers’ concepts of fluency in mathematics(MTCF) and teaching efficiency, as well as their teaching practices that support creativity(TPSC) and teaching efficiency, and whether gender (male-female) is a moderator variable in this relationship. The study sample consisted of (170) teachers divided into (103) male and (67) female. The results of the study concluded that there is a weak, positive, and significant correlation between teachers’ concepts of fluency in mathematics and their teaching efficiency, as well as a medium, positive, and significant correlation between teaching practices that support creativity and their teaching efficiency, …

A Proposed Program In Earth And Space Based On The Next Generation Science Standards (Ngss) To Develop Some Habits Of Mind For Kindergarten Children, Mona Hashim Alzahrani

University of Bisha Journal for Educational Sciences

The study aimed to prepare a list of (NGSS) standards that must be available in the content of the kindergarten curriculum, with determining the level of inclusion of the three dimensions of the (NGSS) standards in the content of kindergarten curricula, and to develop some habits of reasoning and performance skills among kindergarten students, and the descriptive approach was used. And the experimental approach to achieve the study through application on consisting of 15 children in the kindergarten stage, whose ages range from (4-6) years. The dimensions and sum of the performance skills test and the dimensions and sum of …

The Factorial Construction Of The Psychological Capital Scale And Its Relationship To Some Variables Among Faculty Members At Al-Baha University, Bandar Hamdan Ahmed Alzahrani

University of Bisha Journal for Educational Sciences

The study aimed to reveal the factors contributing to the construction of the psychological capital variable among faculty members at Al-Baha University. And to identify the differences between the average scores of the study sample on the psychological capital scale, which are attributed to the impact of the variable of sex, the nature of the college, nationality, and academic rank. The study used the psychological capital scale prepared by the researcher, and the results of the study showed the presence of four main factors constituting psychological capital: hope, self-efficacy, flexibility, optimism, and the absence of a statistically significant difference between …

The Impact Of Electronic Activities On The Development Of Multimedia Production Skills Among Students Of The Faculty Of Education At Shaqra University, Saud Saad Faize Alakloby

University of Bisha Journal for Educational Sciences

The employment of electronic activities in the learning and processes requires the teacher and the learner multiple skills, including the skill of multimedia, which has become one of the necessities necessary for learning, Therefore, this study aimed to find out the effectiveness of electronic activities in developing multimedia skills among students of the Faculty of Education at Shaqra University, and the study sample consisted of 42 female and female students who were divided into 21 female students for the control group that underwent the traditional method, 21 female students for the experimental group that underwent the strategy of electronic activities …

The Role Of Directors Of Offices In Al-Madinah Al-Munawwarah Region To Achieve The Competitive Advantage Of Secondary Schools From The Point Of View Of School Leaders, Abdullah Ali Altammam, Wafiah Othman Alsubhi

University of Bisha Journal for Educational Sciences

The research is to assess how education directors in Al-Madinah Al-Munawrah region are taking their roles in human resources, material/financial resources, education services quality, innovation/creativity and beneficiary satisfaction as to achieve competitive advantage of the secondary schools, in viewpoints of school leaders. It also aims to verify the statistical significance variances in responses of research sample individuals to the roles of the education directors in Al-Madinah Al-Munawrah region in achieving the competitive advantage of the secondary schools due to selected variables (i.e. gender, academic degree and years of experience). To this end, the descriptive survey method was used, and questionnaire …

Editorial, Ubjes Editorial Office

University of Bisha Journal for Educational Sciences

No abstract provided.

A Proposal For Enhancing The Performance Of The Academic Departments At Shaqra University According To The Serrat Model For The Learning Organization, Manal Mohammed Alsaab

University of Bisha Journal for Educational Sciences

This study aims to identify the applying degree of the learning organization dimensions according to the (Serrat model, 2010) in the academic departments at SHAQRA University. The study also aims to develop a proposal for enhancing the performance of the academic departments at SHAQRA University according to the Serrat model for the learning organization. The researcher followed the descriptive survey methodology as the survey is the study tool. The study population includes the staff members at SHAQRA University and a sample averaged (256) members. The study findings revealed that the practice degree of the learning organization dimensions in the academic …

Extending The Technology Acceptance Model Of Efl Teachers' Telegram Technology By Incorporating Subjective Norms And Self-Efficacy Constructs, Hamed Ali Al-Shahrani

University of Bisha Journal for Educational Sciences

In the Kingdom of Saudi Arabia (KSA), Telegram is one of the most popular social media networks. A deeper knowledge of the numerous elements influencing the intention of English as a Foreign Language (EFL) instructors to use Telegram could aid researchers and producers of educational technology in developing more effective and acceptable telegram technology. This study investigates the factors influencing EFL teachers' intentions to utilize Telegram for educational purposes in Saudi Arabia, given the increasing popularity of Telegram's use in education. To validate the measures and proposed research approach, 257 EFL educators were polled. A self-reporting questionnaire was used to …

An Electronic Survey Study Draw A Proposed Strategy, Kholod Mohamad Zain Aldeen, Aisha Al-Omari

University of Bisha Journal for Educational Sciences

education (public and university) in combating extremism and deviant intellectual currents from faculty members' and teachers' perspectives. A total of 525 Saudi university faculty members and general education teachers were surveyed using two electronic questionnaires. Arithmetic averages and standard deviations, One-way ANOVA, Scheffé's test, Pearson's correlation coefficient, and Cronbach's alpha stability coefficient were used as statistical methods. The study statistically identifies the differences between the study sample at the level of significance (0.05). Key findings indicated that there are statistically significant differences between the sample members at the significance level (0.05). The study concluded that a clear picture was drawn …

The Effect Of A Proposed Training Program To Develop Procedural Research Skills Among Social Studies Teachers In Al -Majma'ah Province, Nasser Othman Rashid Alothman

University of Bisha Journal for Educational Sciences

The study aimed at identifying the effectiveness of a training program devoted to developing procedural research skills of social studies teachers in the Kingdom of Saudi Arabia. To achieve the objectives of the study, the researcher used the descriptive and quasi-experimental approach for a sample group consisting of 20 teachers, to whom a cognitive test was applied for pre and post measurement of the degree to which teachers acquire the knowledge and skills of procedural research. The study concluded that, there are statistically significant differences in the average degrees of the cognitive aspect related to the procedural research skills between …

The Role Of Shaqra University In Promoting The Concept Of Global Citizenship From The Students, Haifa Alfozan

University of Bisha Journal for Educational Sciences

The problem of the study is about the role of Shaqra University in promoting the concept of global citizenship from the students' point of view. The study aimed to identify the role of each of: university policy, faculty members, academic courses and university activities in promoting the concept of global citizenship from the point of view of female students, and knowing the extent to which there are statistically significant differences in the answers of the sample members, towards the degree of the study themes, due to the personal variables. Descriptive survey method was used. The study was applied to a …

Strategic Flexibility And Its Relationship With The Effectiveness Of Strategic Decision Making In Emerging Saudi Universities. "A Field Study"., Fahad H. Alebieri

University of Bisha Journal for Educational Sciences

This study aimed at identifying the degree of practicing strategic flexibility and its relationship with the effectiveness of making strategic decision in Saudi emerging Universities from the perspective of academic leaders. The descriptive correlative approach was used by developing a 56-item questionnaire. It was applied to a sample that consisted of (143) academic leaders who were chosen randomly. The results showed that the degree of strategic flexibility in in emerging Saudi Universities was medium with an average of (2.86), and the degree of the effectiveness of making strategic decisions was medium with an average of (2.79). The results found that …

Islamic Rooting Of Critical Thinking Standards Within Prophet Moses Parable, Peace Be Upon Him And Alkhidhr, Mona Dehaish Alqurashy

University of Bisha Journal for Educational Sciences

The study aims at identify the Islamic rooting of eight critical thinking standards, which consist of clarity, accuracy, truthfulness, association, depth, breadth, logic, significance, and importance, represented within the Prophet Moses Parable - peace be upon him - and AlKhidhr. To achieve the aim, the researcher has adopted a descriptive method built around the deductive approach. The study resulted in a set of findings which indicates that the Holy Qur’an contains critical thinking and that the eight standards for critical thinking as mentioned by scholars and thinking theorists have clearly appeared in the Parable of Prophet Moses, peace be upon …

The Donut Hole Fall 2025, Medicare Donations & Design Committee

Donut Hole Newsletter

• 🗓 Fall 2025 Event Calendar – 11 total events (nine in-person across six cities and two virtual events).
• 🌞 Oak Park Summer Event – Experiences and outcomes from our Summer Medicare Health Fair.
• 💆 Class Wellness Activities – Highlights of faculty- and staff-led sessions and student experiences.
• 🤝 Mentor-Mentee Program – CV review, mock interviews, and longitudinal mentorships based on shared interests, including interviews with current participants.
• 👩‍🏫 New Medicare Faculty Introductions
• …and much more!

Engagement By Design: Belongingness, Cultural Value Orientations, And Pathways Into Emerging Technologies, Daisuke Akiba, Michael Perrone, Caterina Almendral, Rebecca Garte

Publications and Research

This theoretical article examines how belongingness, defined as the sense that one’s participation is legitimate and valued, interacts with cultural value orientations to help explain persistent disparities in U.S. technology engagement, including emerging technologies, across racial and ethnic groups. While structural barriers (e.g., racism, poverty, linguistic bias, etc.) remain essential to understanding such inequity, we argue that engagement patterns in technology also reflect how different cultural communities may define and experience belongingness in relation to digital domains. Drawing on Triandis and Gelfand’s framework, and focusing specifically on educational contexts, we propose the Belongingness through Cultural Value Alignment (BCVA) model, whereby …

Raising Riyadh’S Readiness To Host Expo 2030 And World Cup 2034 Visitors, Mohammed Ahmed Jabri, Mohammad Alghamdi

Emirates Journal for Engineering Research

Riyadh is the focus of attention of many local and expatriate tourists, and is witnessing a qualitative shift and rapid development in preparation for hosting Expo Riyadh 2030 and the FIFA World Cup 2034. This research sheds light on an important topic, which is the need to provide sufficient inventory in the hospitality sector to meet the expected needs for these two years. The research followed the methodology of studying and analysing data and statistics collected from the annual reports of the Ministry of Tourism and the General Authority for Statistics (Second data resource); to try to predict the reality …

Synergistic Effects Of Nano-Additives And Aggregate Type On The Mechanical And Hydraulic Performance Of Pervious Concrete Pavements, Rayan Khalid Rahman, Jamal I. Kakrasul

Polytechnic Journal

Increasing demands for sustainable urban infrastructure have made pervious concrete emerge as a promising pavement material due to its ability to combine load-bearing capacity with stormwater infiltration. This paper explores the synergetic effect of nanomaterials on the mechanical, hydraulic and durability characteristics of pervious concrete made with three different coarse aggregates: crushed limestone (CL), river aggregate (RA), and recycled concrete aggregate (RCA). Twelve concrete mixes were prepared using varying combinations of nano-modified mixes to investigate their influence on key properties, including dry density, void content, compressive strength, tensile strength, permeability and abrasion resistance. The results showed that river aggregate …

Temporal Trends In The Epidemiology Of Hip Osteoarthritis In The Usa, 1990-2019: A Cross-Sectional Time-Series Study Using Gbd Data, Arsalaan Sayyed, Gabrielle Lucia Dykhouse, Taylor Manes, Cameron J. Sabet, Minali Gautami Nemani, Ambrose Loc Ngo, Ayah Ibrahim, Phillip C. Mckegg, Jignesh Patel

Student Publications

Objectives: To evaluate temporal trends in the epidemiology of hip osteoarthritis (OA) in the USA from 1990 to 2019, with stratification by sex and geographic region.

Design: Cross-sectional time-series analysis using secondary data from the Global Burden of Disease (GBD) study.

Setting: US population-based analysis, stratified by the four US Census Bureau regions: Northeast, Midwest, South and West.

Participants: De-identified, aggregate population-level data representing all adults in the USA from 1990 to 2019, drawn from the GBD database.

Primary and secondary outcome measures: Age-standardised rates per 100 000 population for years lived with disability (YLDs), prevalence and incidence of hip …