Digital Commons Network^™

Polychlorinated Biphenyls Alter Estrogen Receptor Β-Mediated Epigenetic Regulation, Promoting Endometriosis, Jaeyeong Jeong, Juhee Sim, Mi Jin Park, John P Lydon, Xiaoming Guan, Sang Jun Han

Faculty, Staff and Students Publications

Endometriosis is a pathological condition characterized by the ectopic growth of endometrial cells, leading to chronic pelvic pain and infertility. Epidemiological studies have associated exposure to dioxin-like polychlorinated biphenyls, particularly PCB126, with an increased risk of endometriosis. However, the underlying mechanisms of this association remain poorly understood. We utilized a surgically induced endometriosis mouse model and human endometrial cell lines to assess the impact of PCB126 on endometriosis progression. Mice were exposed to environmentally relevant doses of PCB126. Endometriotic lesion growth, estrogen receptor signaling, receptor tyrosine kinase activity, and gene expression changes induced by PCB126-mediated elevation of DNA methyltransferase 3A …

Sers And Seira Detection Of Polycyclic Aromatic Hydrocarbons And Their Derivatives In Murine Tissues: Bioaccumulation And Clearance, Guo Dong Zhou, Sachin B Jorveka, Parmeet Dhindsa, Nagireddy Putluri, Peter Nordlander, Melissa A Suter, Bhagavatula Moorthy, Naomi J Halas

Faculty, Staff and Students Publications

The toxicological effects of polycyclic aromatic hydrocarbons (PAHs) and polycyclic aromatic compounds (PACs) have attracted considerable research interest due to their known bioaccumulation. However, time-resolved and longitudinal studies that examine in vivo bioaccumulation and clearance remain limited. Here we use Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Infrared Absorption (SEIRA) spectroscopies to detect and track the presence of two PAHs: pyrene, benzo[a]pyrene, and one PAC: 5,12-naphthacenequinone, in murine organ tissues. Mice were exposed to a three-component mixture of these three chemicals, then their organs were collected at 24-, 48-, and 72- hours post-exposure. The accumulation of each of these chemicals in …

Dual Targeting Of Orphan Nuclear Receptors Nr4a1 And Nr4a2 For Nonhormonal Endometriosis Therapy, Da Mi Kim, Lei Zhang, Gus Wright, Amanuel Hailemariam, Arafat Rahman Oany, Sang Jun Han, Stephen Safe

Faculty, Staff and Students Publications

Previous studies show that orphan nuclear receptor 4A1 (NR4A1) regulates endometriotic cell growth, survival, estrogen receptor β (ERβ), mechanistic target of rapamycin signaling and fibrosis. NR4A2 is also expressed in epithelial and stromal derived endometriotic cells, and in this study the effects of 1,1-bis(3'-indolyl)-(3,5-disubstitutedphenyl)methane (DIM-3,5) dual NR4A1/nuclear receptor 4A2 (NR4A2) ligands and knockdown of NR4A1 and NR4A2 were investigated. The dual NR4A1/2 DIM-3,5 analogs inhibited previously identified proendometriotic pathways and gene products, and they also inhibited TWIST1 and multiple markers associated with epithelial-to-mesenchymal transition (EMT). The results show that both NR4A1 and NR4A2 regulate the same pathways, including endometriotic cell …

Acceptance And Commitment Therapy Versus Progressive Relaxation Training For Misophonia: A Randomized Controlled Trial, Michael P. Twohig, Karen Muñoz, Julie M. Petersen, Mercedes G. Woolley, Emily M. Bowers, Marissa L. Donahue, Doris Velasquez, Diana Ortiz, Leila K. Capel, Guadalupe G. San Miguel

Psychology Faculty Publications

Objective: To date, no in-person-delivered psychotherapies for adults with misophonia have been tested against active control conditions. The purpose of this study was to test the preliminary efficacy of acceptance and commitment therapy (ACT), supplemented with audiologically informed behavioral strategies (e.g., functional adaptations to manage exposure to misophonic sounds), versus education and progressive relaxation training (PRT) for adults with misophonia.

Method: In a well-controlled randomized trial, 60 adults were randomized to ACT or PRT and each received 12, one-hour sessions of individualized psychotherapy for misophonia. Audiological and psychological assessments were conducted at baseline to assess for eligibility and severity of …

Mission-Driven Initiatives & Undertakings For Student Success: Ai For Ai, Jessica Garner, Kay Coates

University Libraries: Faculty Presentations

No abstract provided.

Artificial Intelligence And Energy Democracy, Heather E. Payne, Joel B. Eisen

San Diego Law Review

Artificial intelligence (AI) is quickly transforming many professional activities, and the electric grid has already started to see adverse impacts from its use, such as the burgeoning demand for electricity from data centers. This Article acknowledges these impacts, but also demonstrates that AI can be put to beneficial use on the grid. It proposes and describes a specific use of AI: assisting citizen intervenors in public utility commission (PUC) proceedings, who currently face barriers to participation due to the technical complexity and confidentiality imposed by monopoly utilities. The Article describes how AI can assist intervenors to overcome the barriers to …

Regulating Government Statements Regarding Disinformation On Social Media, Michael J. Marando

San Diego Law Review

The United States saw in the 2016 presidential election how Russia used social media to spread disinformation. Russia engaged in similar conduct during the lead-up to its full-scale invasion of Ukraine in 2022 and, most recently, during the days before the 2024 U.S. presidential election. An interesting development, however, has been the U.S. government’s issuance of public statements countering these disinformation attempts. This Article argues that such public statements are quite helpful, both in countering the disinformation and allowing social media companies to legitimately enforce their content. However, these types of statements pose risks and, at the extreme, could be …

Beyond Racial Categorization In Sports Cardiology: A Systematic Review Of Cardiac Adaptations In Athletes, Douglas Corsi, Rafael Hernandez, Jasmine Yimeng Bao, Stephen Garrova, David Shipon

Division of Cardiology Faculty Papers

Background/Objectives: Race-based cardiac screening criteria in sports cardiology, including the “Black athlete’s heart” concept, assume biological distinctions that may not reflect physiological reality. This systematic review evaluates whether geographic ancestry provides more clinically relevant predictors of cardiac adaptation than racial categorization. Methods: PubMed was searched (January 2005–July 2025) for studies examining cardiac adaptations in athletes by ethnicity. Data extraction captured demographics, geographic origin, cardiac assessments, and outcomes. Narrative synthesis was employed due to methodological heterogeneity. Results: Forty-seven studies (n = 66,130) revealed substantial within-race heterogeneity. The “Black athlete repolarization variant” prevalence ranged from 1.8% (Brazilian) to 30% (Ghanaian) Black athletes. …

Cosmopolitan Spirits: Islam And The Experimental Cosmologies Of Egypt's Spiritualist Movement, 1947–1960, Arthur Shiwa Zárate

Faculty Research, Scholarly, and Creative Activity

This article considers the history of Egypt’s mid-twentieth-century Spiritualist movement through an examination of its periodical, a monthly Arabic magazine called Alam al-Ruh (The World of the Spirit) (1947–1960). As it shows, Egyptian Spiritualists defended and promoted their project by crafting an experimental cosmology, one that blended claims about empirical verification with elements of Islamic and Spiritualist cosmologies. It further shows how this combination of scientism and cosmology reflects a core dynamic within the history of scientific exploration in the Islamic world. Like spiritual seekers and occult practitioners in Muslim societies elsewhere, Egyptian Spiritualists positioned their project as one of …

Liquid 1h-1,2,3-Triazole Interpreted As A Continuous, Self-Assembled Hydrogen-Bonded Linear Network, Ashley E. Williams, Anna Craigholan, Leah A. Surbaugh, Aron J. Huckaba, Jared H. Delcamp, Gregory S. Tschumper, Nathan I. Hammer

Chemistry Faculty Research & Creative Works

The molecular-level organization of 1H-1,2,3-triazole in the liquid state is described as an extended hydrogen-bonded network, reminiscent of linear solution-phase polymer chains. Raman, IR, and no-D NMR spectroscopic data interpreted using density functional theory (DFT) computations reveal no evidence of the lower-energy 2H- tautomer or isolated 1H- monomers. Spectroscopic and computational results are consistent with an extended network of strong intermolecular hydrogen bonds throughout the pure liquid and explain earlier X-ray and solution-phase studies. Our computations indicate that the Gibbs free energy of ring-like structures for the most part increases with the number of fragments whereas it decreases for extended …

Biography Of A Friendship: Maryat Lee And Flannery O’Connor, Carole K. Harris

Publications and Research

No abstract provided.

Prevalence Of Sleep Disturbance And Associated Risk Factors In Degenerative Cervical Myelopathy, Salim Yakdan, Karan Joseph, Jingyi Zhang, Miguel A Ruiz-Cardozo, Aryan Pradhan, Alisha Dhallan, Faraz Arkam, Willliam Mualem, Garrison Bentz, Diogo P Moniz Garcia, Benjamin Plog, Alexander T Yahanda, Daniel Hafez, Wilson Z Ray, Camilo A Molina, Jacob K Greenberg

2020-Current year OA Pubs

Retrospective Case-Control.

A Plain Language Summary Publication Of Patients' Survival With Endometrial Cancer Treated With Dostarlimab Plus Carboplatin-Paclitaxel, Matthew A Powell, Carolyn Mccourt, Et Al.

2020-Current year OA Pubs

What is the purpose of this PLS-P? The purpose of this plain language summary of publication is to help you understand recent findings from Part 1 of the RUBY study (full name ENGOT-EN6/GOG3031/RUBY trial). • Researchers sometimes study new combinations of already approved individual treatments to see if the combinations work well together and if they are safe to prescribe to patients. • In Part 1 of the RUBY study, the combination of

Problem-Solving Training To Improve Caregiver Burden And Depressive Symptoms Among Dementia Caregivers: Personal And Clinical Factors Of Responders Vs. Non-Responders, Shannon B. Juengst, Matthew Lee Smith, Kristin Wilmoth, Brittany Wright, Gang Han, Charlene Supnet, Gladys Maestre

School of Medicine Publications

Introduction: Metacognitive strategy training interventions, like Problem-Solving Training/Descubriendo Soluciones Juntos (PST/DSJ), have efficacy for improving caregiver burden and depressive symptoms. We previously demonstrated that PST/DSJ improved caregiver burden and depressive symptoms among caregivers of adults with Alzheimer’s Disease and related dementias (ADRD), regardless of the number of sessions or boosters received. However, these results did not examine factors characterizing those who responded (improvement in caregiver burden or depressive symptoms) or did not respond to the intervention.

Objective: To identify key personal and clinical factors associated with response to PST/DSJ. Personal factors included age, gender, race, Hispanic ethnicity, education, and employment …

Germline Determinants Of Toxicity And Efficacy In Patients With Large B-Cell Lymphoma Treated With Car T-Cell Therapy, Paolo Strati, Amanda Brandt, Anath C Lionel, Jared Henderson, Jason R Westin, Elizabeth J Shpall, Jeremy Ramdial, Neeraj Saini, Sairah Ahmed, Christopher Flowers, Sattva S Neelapu, Michelle A T Hildebrandt

Faculty, Staff and Student Publications

Background: Recent data have suggested that germline genetic aberrations can affect outcomes in patients with large B-cell lymphoma (LBCL) treated with chimeric antigen receptor T-cell therapy (CART). However, a comprehensive analysis of germline determinants of response and toxicity after CART has not yet been described.

Methods: Genome-wide genotyping was performed in 170 patients with LBCL treated with standard of care axicabtagene ciloleucel. Polygenic risk score instruments for blood cell traits and inflammatory markers were obtained from the PGS Catalog and analyzed using PRSice-2. Exploratory gene-based and genome-wide association study analyses were performed. Genetic ancestry of the patients with LBCL was …

The Role Of Traumatic Brain Injury On Intimate Partner Violence And Changes In Mental Health From Late Adolescence To Young Adulthood, Eric J Connolly, Elizabeth Baumler, Deborah M Little, Meghan L Royle, Anne C Wingert, Leila Wood, Jeff R Temple

Faculty, Staff and Student Publications

Purpose: Intimate partner violence (IPV) victimization and traumatic brain injury (TBI) are common correlates of mental health problems in adolescence. However, research has yet to investigate whether IPV victimization is related to developmental changes in mental health, as well as the contributing role that TBI may play in conditioning this association. We address this gap by analyzing longitudinal data with well-validated measures of mental health from an ethnically diverse sample of adolescents.

Methods: Prospective data from the Dating it Safe sample (n = 699) were used to measure IPV victimization, depression, post-traumatic stress, binge drinking, and TBI from 2015 to …

The 2x10 Intervention In Teacher Preparation: The Use Of A Simple Relationship-Building Strategy By Teacher Candidates, Kara Conniff, Leah Wasburn-Moses

Mid-Western Educational Researcher

Classroom management is a significant and longstanding need for teachers and the field of teacher preparation. Teacher candidates often feel unprepared to deal with classroom and behavior management (Flower, McKenna & Harin, 2017). One of the most important management skills is relationship building (Yassine, Tipton-Fisler, & Kati, 2020). The 2x10 Intervention is a relationship building technique that improves classroom behavior and is both simple and efficient for teachers to implement (Smith & Lambert, 2005). This study examines the use of the 2x10 Intervention by 18 student teachers at one Midwestern university, during their clinical placement. Data were collected on student …

Without Them, There Is No You: The Role Of Personal Choice And History In Resisting Political Control, Heidi Turner

Asian American Literature: Discourses & Pedagogies

In 2011, Korean-American journalist Suki Kim went undercover as an English teacher at the Pyongyang University of Science and Technology, working to teach her students while simultaneously recording everything she could about the workings of the Democratic People’s Republic of Korea (DPRK). In 2014, her book Without You, There is No Us was published as a memoir, in part due to the inclusion of personal details considered less relevant to the story, thereby undercutting her journalistic credentials.

Here, using C. S. Lewis’s The Abolition of Man as a theoretical framework for understanding oppressive regimes and the ways that they control …

Transpacific Rhizomatic Migration In Kyoung H. Park’S Mina: Settler Desire And Identity Formation In Korean-Latin American Literature In The U.S., Chase Kim

Asian American Literature: Discourses & Pedagogies

The Korean diaspora to the United States is a phenomenon that has long been analyzed for its sociocultural, political, and economic implications. However, generally ignored by scholarship of frameworks such as the transpacific is Korean-Latin American remigration to the United States. Korean migration to Latin America and this group’s subsequent migration to the US was motivated largely by economic factors such as the availability of Latin American agricultural labor in the mid-1960s and the growth of Korean-American professional communities during the 1980s. Situating this migration in a transpacific framework improves our understanding of settler colonial desire and identity formation. I …

Introduction To Volume Thirteen: Teaching In Dangerous Times, Noelle Brada-Williams

Asian American Literature: Discourses & Pedagogies

No abstract provided.

Who Owns The Truth? Another Look At The Plagiarism Debate, Jerry Moon

Ellen White and Current Issues Symposium

No abstract provided.

Ellen White’S Racial Background, James R. Nix

Ellen White and Current Issues Symposium

No abstract provided.

Value Added 3d Modeling – Lower Crow Dam Spillway Modification And Rehabilitation Project, Justin Bartels

4th International Workshop on Labyrinth and Piano Key Weirs

The Confederated Salish and Kootenai Tribes (CSKT) have been operating Lower Crow Dam under restricted reservoir levels since 2008 due to significant structural and spillway capacity deficiencies that have increased risk to dam safety. Stantec was contracted by the CSKT to evaluate rehabilitation options and provide final design for the new spillway. The focus of this paper is to describe the design methodology and spillway selection process with an emphasis on the hydraulic modeling completed to support the final spillway arrangement. The design approach included the evaluation of various spillway types including gated, Obermeyer, fuse gate, ogee, labyrinth, and piano …

Government Communication Strategies And Citizen Participation: A Thematic Review, Ojonugwa Emmanuel, Andrew I. E. Ewoh

Journal of Public Management & Social Policy

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Co-Creation As A Trust-Building Tool: An Application To Ghanaian Local Governments, Richard K. Nkrumah

Journal of Public Management & Social Policy

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Devolution And Administrative Burden In Tanf: An Assessment Of Welfare Rules, Rhucha P. Samudra

Journal of Public Management & Social Policy

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Gun Violence In Charlottesville, Virginia: Creating A Community-Centered Public Safety Ecosystem, Seth G. Coven

Journal of Public Management & Social Policy

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Substance Use And Rural Homelessness In Texas Communities: The Need For Supportive Services, Abraham David Benavides, Federickia Washington, Chandra Donnell Carey, Justin Watts, Jyoti Aggarwal

Journal of Public Management & Social Policy

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An Oral History Of African American Seniors Seeking Housing, Health, And Climate Justice In The Gulf Coast After Hurricane Harvey, Jessica April Ward, Glenn S. Johnson

Journal of Public Management & Social Policy

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Parents’ Dispositions On Social Emotional Learning And Their Policy Imperatives: The Relevance Of Context/Locality, Nicholas O. Alozie, Megan Armstrong, Kathy Thomas

Journal of Public Management & Social Policy

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