Digital Commons Network^™

Discriminative Accuracy Of Cha2ds2-Vasc Score, And Development Of Predictive Accuracy Model Using Machine Learning For Ischemic Stroke Risk In Cardiac Amyloidosis And Atrial Fibrillation, Waqas Ullah, Abhinav Nair, Eric Warner, Salman Zahid, Mansoor Rahman, Palwasha Khan, Indranee Rajapreyar, Sridhara S. Yaddanapudi, M. Chadi Alraies, Said Ashraf, Jeffery Van Hook, Yegeny Brailovsky

Department of Medicine Faculty Papers

BACKGROUND: CHA2DS2-VASc score in cardiac amyloidosis (CA) with atrial fibrillation (AF) is believed to underestimate ischemic stroke risk, necessitating a better predictive model.

METHODS: Data were obtained from the National Readmission Database (NRD). Outcomes between CA-AF and no-CA-AF were compared using multivariate regression analysis to calculate adjusted odds ratios (aORs). AutoScore, an interpretable machine learning framework, was used to develop a stroke risk prediction model, and its predictive accuracy was evaluated with an area under the curve (AUC) using the receiver operating characteristic analysis.

RESULTS: A total of 11,860,804 (CA-AF 22,687 (0.19%) and no-CA-AF 11,838,117) patients were identified from 2015 …

Wired For Words: God's Design For Language And Learning, Gwen R. Marra

Faculty Work Comprehensive List

"Understanding the process of learning to read reminds me of the importance of attending to and truly engaging with the voices and stories of others."

Posting about ­­­­­­­­the power of literacy from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Wired for Words

Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Funan He, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu

Faculty, Staff and Student Publications

B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27–IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 …

The Xeremies Of The Banda Municipal De Barcelona: From The Symphonic Turn Of The Cobla To The Invention Of The Barítona, Nuria Bonet, Albert Fontelles-Ramonet

School of Art, Design and Architecture

During the early twentieth century, Catalonia experienced a period of great cultural and musical development through the Noucentisme movement, which aimed to elevate its national culture to a symbol of high art. The xeremies (shawms) of the cobla ensemble, which played the sardana genre, were integrated into symphonic and chamber repertoire. This required the technical improvement of the tible (treble) and tenora (tenor) xeremies, but also encouraged the invention of new instruments in the shawm family. The barítona (baritone shawm) was premiered in 1930 by the Banda Municipal de Barcelona and represents a milestone in Catalan music in the tumultuous …

Engaging Each Other: Harnessing The Power Of A Multigenerational Workforce In Academic Libraries, Kay Coates, Rachel~Anne Spencer

University Libraries: Faculty Presentations

This presentation focuses on employee engagement and the multigenerational workforce in academic libraries. In this session, the professional values and strengths of Baby Boomers, Gen X, Millennials, and Gen Z will be discussed by examining how these generations can collaborate and support each other given their different skill sets, attitudes, and lived experiences. Through the application of Kahn’s Theory of Employee Engagement and the Appreciative Inquiry approach, the focus will be on the dynamic interplay of the generations’ engagement and interaction in the workforce. The goal being to foster productive harmony that leverages the unique contributions of each generation.

Creating Culture: Enabling Research-Active Practitioners To Thrive, Elizabeth Rajan, Philippa Clay, Shani Ackford, Katherine Broomfield

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

The George-Anne Deep Dive, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Establishing A Large Public Involvement Network For A Chronic Pain Research Consortium In The Uk, Sharon Grieve, Rosie Harrison, Noureen Shivji, Ian Taverner, Colin Wilkinson, Jo Lloyd, Carolyn Chew-Graham, Candy Mccabe, Ellen Readman, Lisa Austin, Adele Higginbottom, Ed Keogh

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Getubetter Lockout Report Evaluation, Samantha Jenkins, Emma Lees, Sharon Viol, Simon Ingram, Faye Goodwin

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Occupational Therapy Research Cafes – A Novel Route To Embed Research Into Practice, Mary Harvey

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

So, What Does Well-Being Mean To You? The Understanding Of Well-Being By Service Users In A Local Authority Setting: A Qualitative Study, Rachel Stott

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Workplace Wellbeing Within The Pharmacy Team At University Hospitals Bristol And Weston Nhs Foundation Trust, Helen Ireland

South West Clinical School Journal

#400WORDS: DELIVERING A RESEARCH SKILLED WORKFORCE SPECIAL EDITION

Developing A Research Skilled Workforce In The South West: Nurturing Capacity, Carrie Biddle, Ralph Hammond, Gina Kallis, Susie Pearce

South West Clinical School Journal

Editorial

Representation, Dynamics And Optimization Of Physical Structures, Fan Feng

Dartmouth College Ph.D Dissertations

Computational tools play a vital role in structural analysis and design, enabling engineers and researchers to optimize performance, reduce material usage, and explore novel configurations across solids and fluids. Capturing, analyzing, and optimizing these structures while balancing efficiency, stability, and adaptability remains a central challenge. This thesis proposes three complementary methods that advance representation, simulation, and optimization. We present an impulse (gauge) fluid formulation that utilizes the impulse gauge variable to reduce numerical diffusion and better preserve coherent flow features such as vorticity at practical resolutions. We introduce a differentiable Voronoi representation for cellular solids that provides smooth implicit boundaries …

Perioperative Goal Directed Versus Conventional Fluid Therapy In Head And Neck Free Flap Surgery: A Systematic Review And Meta-Analysis, Faisal Shamim, Adnan A. Khan, Mahnoor Sohail, Rayaan A. Yunus, Mahad Sohail, Tahir Munir, Muhammad S. Shahid, Haissan Iftikhar

Sultan Qaboos University Medical Journal

Head and neck free flap surgery is associated with considerable morbidity and mortality. Goal-directed fluid therapy (GDFT) has been increasingly adopted in perioperative care; however, its benefit over conventional fluid therapy (CFT) in this setting remains uncertain. This systematic review and meta-analysis assessed the effect of GDFT versus CFT on post-operative outcomes. A comprehensive search of PubMed, Web of Science, Cochrane Library, Dental/Oral Science, and Google Scholar identified randomised controlled trials published between 2010 and 2023. Three studies involving 262 patients (130 GDFT, 132 CFT) were included. Pooled analysis showed no significant difference in flap failure between groups, but CFT …

Does Idiosyncratic Volatility Follow A Random-Walk? Evidence From U.S. Stocks, Zihan Cao, Ossama Elhadary

Publications and Research

In asset pricing literature, idiosyncratic volatility (IVOL) measures the firm-specific risk that is not explained by broader market movements. In this study, I investigate whether the idiosyncratic volatility (IVOL) of individual stocks follows a random-walk. Using monthly residuals from the Fama-French three-factor model (Fama & French, 1993), I estimate IVOL for more than 11,000 U.S. stocks, and apply the Augmented Dickey-Fuller test (Said & Dickey, 1984) to determine whether IVOL behaves like a random-walk. While most stocks display random-walk behavior, the proportion varies across industries, with some sectors showing deviations from random-walk behavior. Stocks with different levels of average return …

The Case For Automatic Enrollment In Trump Accounts: Lessons From Maine’S Cda, Margaret Clancy, Jin Huang, Michael Sherraden

Center for Social Development Research

In 2014, Maine's statewide Child Development Policy, the My Alfond Grant, transitioned from an opt-in enrollment structure to an automatic one. Written as federal policymakers weigh enrollment options for the new Trump Accounts, this brief highlights lessons from Maine's transition and findings from the the SEED for Oklahoma Kids experiment, offering recommendations for implementing the new federal policy.

The Transtheoretical Model Of Behavior Change To Promote Anti-Racist Behaviors In Medical Settings, Amanda Almond

Publications and Research

Abstract: This paper proposes the application of the transtheoretical model, a stage-matched process for effecting change, to better encourage anti-racist behaviors and methods among health care professionals in medical settings. Despite widespread organizational implementation of diversity, equity and inclusion (DEI) initiatives, which are aimed at reducing racial health and healthcare inequities across the United States, the absence of a theoretical framework for change has made it all but impossible to standardize meaningful anti-racist practices – a point of particular concern as President Donald Trump’s administration rolls back DEI efforts and requirements alike. Translational and clinical sciences aim for a gold …

Liberatory And Public Health Harm Reduction: Retracing Genealogies, Forming Queer Imaginaries, Ana Sofia Harrison

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Shinydegsem: An Interactive Application For Pathway Perturbation Analysis In Gene Expression Studies Via Structural Equation Modeling, Zhehan Jiang, Jihong Zhang, Yuanfang Liu, Jinying Ouyang, Linlin Sun, Hao Guo

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Background Researchers in biology and bioinformatics are increasingly interested in unraveling the complex mechanisms underlying phenotypic variations. A key challenge lies in identifying perturbed biological pathways and understanding how these perturbations propagate through intricate gene regulatory networks. Results To address this challenge, we developed ShinyDegSEM, an interactive R Shiny application that leverages structural equation modeling (SEM) to facilitate pathway perturbation analysis in gene expression studies. ShinyDegSEM streamlines identifying differentially expressed genes (DEGs), generating pathway models based on biological knowledge, and evaluating these models to uncover perturbed pathway modules. This article is a tutorial to guide users through the analysis workflow, …

Young Carers In Early Childhood - Exploring Experience With The Power Threat Meaning Framework, Carly Ellicott, Alyson Norman, Helen Lloyd, Felicity Dewsbery, Sarah Jones, Shoshana Jones

School of Psychology

This paper presents the first exploration of young carers in early childhood (YCEC), in the context of whole family support, through the application of the Power Threat Meaning Framework (PTMF). Existing contributions to young carer research have shaped social policy, legislation, and practice concerned with whole family approaches to the identification, assessment, and support for young carers globally. To date, the literature has predominantly focused on young carers in middle childhood to young adulthood, contributing to socially constructed Eurocentric ideologies of who young carers are likely to be. As such, YCEC remain disempowered in broader young carer and family science …

Development Of Students Worksheet Based On Project-Based Learning To Train Critical Thinking Skills At Vocational High School, Dia Ayu Permatasari, Harun Nasruddin

Jurnal Pendidikan Sains

Critical thinking is a cognitive skill that helps identify problems and generate solutions, leading to logical decisions or considerations for solving those problems. Students' critical thinking skills can be trained through learning activities to further improve students' critical thinking skills with learning tools. Therefore, this research intends to produce a student worksheet based on project-based learning to train students' critical thinking skills on the colligative properties of solutions. The development research uses the 4D development model from Thiagarajan, limited to the development stage. A limited trial was conducted with 30 students of industrial chemical engineering expertise at Vocational High School …

Development Of Digital Comic Learning Media Based On Mobile Learning On Media: Making Media Materials In Plant Tissue Culture, Sufina Intan Pertiwi, Fauziyah Harahap, Aline Gusti Yolanda Harahap, Marsya Amira Indrawati, Aline Jelita Christiani Simanullang, Yanda Febry Gracea Br Tarigan, Maureen Efriyanti Sitinjak

Jurnal Pendidikan Sains

his research was conducted based on student needs analysis, analysis of learner characteristics, and curriculum analysis, namely the lack of visualization and presentation of concepts and the lack of utilization of interactive technology in the learning process on media material and media making in tissue culture for college students. This study intends to develop digital comic media based on mobile learning and making media materials in tissue culture. This research method used research and development (R&D) with the ADDIE model: analyze, design, develop, implement, and evaluate. The subjects of this study were students of the Department of Biology, Universitas Negeri …

Problem-Based Learning Assisted By Augmented Reality On The Respiratory System Topic: A Study Of Students’ Critical Thinking Skills And Learning Motivation, Nyimas Dilviana, Ade Yeti Nuryantini, Sumiyati Sa'adah

Jurnal Pendidikan Sains

This study aims to examine the effectiveness of the Problem-Based Learning (PBL) model assisted by Augmented Reality (AR) technology regarding the respiratory system in improving students’ critical thinking skills and learning motivation. The research method used was a quasi-experimental design with a one-group pretest-posttest model. The subjects were 30 eleventh-grade students from a public high school in Garut City. Research instruments included a critical thinking test and a learning motivation questionnaire. The results showed a significant improvement in students’ critical thinking scores after the implementation of PBL with AR support. Additionally, learning motivation data analyzed from 16 statement items revealed …

Lessons Learned: Katalin Mérő, Salil Gupta

Journal of Financial Crises

Between 1990 and 2010, Katalin Mérő served in various roles for Hungary’s central bank, Magyar Nemzeti Bank, and the Hungarian Financial Supervisory Authority. She led the Economics, Risk Assessment, and Regulatory Directorate between 2005 and 2019 and was the deputy head of the Financial Stability Department. She was also a member of the Joint Board of Appeal of European Supervisory Authority from 2011 to 2021. Mérő graduated from the Corvinus University of Budapest and received a PhD in 2005 from the Budapest University of Technology and Economics. Since 2016, she has served as an associate professor at Budapest Business School, …

Lessons Learned: Anthony Dowd, Mercedes Cardona

Journal of Financial Crises

Anthony Dowd was an investment banker when former Federal Reserve Chairman Paul Volcker recruited him during the Global Financial Crisis (GFC) to be his chief of staff for the President’s Economic Recovery Advisory Board (PERAB). As chairman of the PERAB, Volcker proposed what would become known as the Volcker Rule, a series of guardrails meant to curb banks’ involvement in proprietary trading and investing in private equity or hedge funds; they were adopted in the Dodd-Frank Act of 2010. When Chairman Volcker founded the Volcker Alliance in 2013, Dowd became a director and its first treasurer. The alliance is a …

Lessons Learned: Grahame Johnson, Mercedes Cardona

Journal of Financial Crises

Grahame Johnson was named managing director of financial stability at the Bank of Canada in November 2019, just months before the outbreak of the COVID-19 pandemic, and became adviser to the governor in 2021. The Bank of Canada responded to the economic effect of the pandemic by launching 10 liquidity facilities—nine of them never attempted before—to repurchase securities such as government and corporate bonds, bank acceptances, and commercial paper. The measures were largely successful, and nine of the 10 facilities were unwound by 2022. The tenth, the Government of Canada Bond Purchase Program (GBPP), transitioned into a quantitative easing program …

What Policy Combinations Worked?: The Effect Of Policy Packages On Bank Lending During Covid-19, Divya Kirti, Maria Soledad Martinez Peria, Prachi Mishra, Jan Strasky

Journal of Financial Crises

In response to COVID-19, countries frequently adopted multiple types of policies to address the economic and financial effects of the pandemic. This paper analyzes the impact on bank lending of combinations or packages of policies (fiscal, monetary, and prudential) adopted across a broad sample of countries. Using a comprehensive policy announcement–level dataset together with bank-level information, we find that lending grew faster at banks in countries that announced large packages combining fiscal, monetary, and prudential measures (“all-out” packages), especially when uncertainty was high. Both the scope and size of policy packages were important: packages combining all three types of policies, …

Lessons Learned: Stijn Claessens, Owen Heaphy

Journal of Financial Crises

After two decades at the World Bank, Stijn Claessens served as assistant director in the research department of the International Monetary Fund (IMF) from 2007 to 2014. From 2015 to early 2017, Claessens was senior adviser in the Division of International Finance at the Federal Reserve Board (Fed), before joining the Bank for International Settlements (BIS) as head of financial stability policy and deputy head of the monetary and economic department in 2017. Claessens left the BIS in September 2023 and is now an executive fellow with the Yale Program for Financial Stability. This Lessons Learned is based on an …

Stressing The Stress Tests, Natasha Sarin, Til Schuermann

Journal of Financial Crises

In the spring of 2023, Silicon Valley Bank, Signature Bank, and First Republic Bank failed, owing to predictable rate hikes by the Federal Reserve. It’s clear from these recent events that the current US stress-testing system is ill-suited to mitigate risk associated with the banking system, especially when looking at smaller regional banks that aren’t subjugated to annual stress testing. Stress testing as a regulatory tool is also exposed to significant legal risks following recent Supreme Court jurisprudence that draws into question the viability of the status quo. Today, regulators and other interested parties must change tacks to craft a …