Digital Commons Network^™

Facts And Hopes Of Chimeric Antigen Receptor-Redirected Nk T Cells, Amy N Courtney, Xin Zhou, Gengwen Tian, Ying Wang, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-engineered invariant NK T cells (CAR-NKT) are a novel cell platform for cancer immunotherapy. Unlike conventional T cells, NKTs are characterized by innate antitumor properties, minimal alloreactivity, and a unique ability to modulate the tumor microenvironment. This article provides a comprehensive overview of preclinical and early clinical studies evaluating CAR-NKTs in both autologous and allogeneic clinical settings. We discuss the contributions of CAR signaling domains, cytokine coexpression, and other functional measures that correlate with CAR-NKT persistence, function, and metabolic fitness. We also discuss the critical role of immunocompetent animal models in elucidating the interactions of CAR-NKTs with …

Mitochondrial Complex Ii Orchestrates Divergent Effects In Cd4+ And Cd8+ T Cells, Keisuke Seike, Shih-Chun A Chu, Yuichi Sumii, Takashi Ikeda, Meng-Chih Wu, Laure Maneix, Dongchang Zhao, Yaping Sun, Marcin Cieslik, Pavan Reddy

Faculty, Staff and Students Publications

Mitochondrial metabolism orchestrates T cell functions, yet the role of specific mitochondrial components in distinct T cell subsets remains poorly understood. Here, we explored the role of mitochondrial complex II (MC II), the only complex from the electron transport chain (ETC) that plays a role in both ETC and metabolism, in regulating T cell functions. Surprisingly, MC II exerts divergent effects on CD4+ and CD8+ T cell activation and function. Using T cell-specific MC II subunit, succinate dehydrogenase A-deficient (SDHA-deficient) mice, we integrated single-cell RNA-seq and metabolic profiling, with in vitro and in vivo T cell functional assays to illuminate …

Transdiagnostic Links Of Reward Processing In Obsessive-Compulsive Disorder And Depression, Kevin M Wagner, Matti Cervin, Jessica S C Cheng, Jasmine Arriaga, Vanessa Zavala Cruz, Dayan Berrones, Josselyn S Muñoz, Renee M Frederick, Jacey L Anderberg, Belinda E Núñez Bracho, Victor R Adorno, Leonardo F Fontenelle, Andrew D Wiese, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), James J Crowley, Eric A Storch

Faculty, Staff and Students Publications

Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.

Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18-88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated …

The Hidden Toll: Atrophy Of Key Central Nervous System Relays In African American Women With Multiple Sclerosis, Nabeela Nathoo, Nur Neyal, Jiye Son, Christopher G Schwarz, Elizabeth J Atkinson, Holly A Morrison, June Kendall Thomas, John D Port, Kejal Kantarci, Orhun H Kantarci, Burcu Zeydan

Faculty, Staff and Students Publications

Background: African American persons with MS (AApwMS) have more aggressive clinical and imaging outcomes than White American pwMS (WApwMS), including lower brain and spinal cord (SC) volumes. However, imaging studies are lacking considering the effects of sex, race, and ethnicity together.

Objective: Compare MS clinical and imaging features among AApwMS and WApwMS, incorporating the modifying effects of sex, race, and ethnicity.

Methods: Clinical variables and MRI were obtained for AApwMS and WApwMS.

Results: Thirty-five MRIs in 28 AApwMS (61 % female) and 255 MRIs in 91 WApwMS (68 % female) were evaluated. AApwMS had a shorter MS disease duration (median …

Loss Of Mfap5 And Its Effect On Skin Homeostasis And Wound Healing, Chen Han, Heidi Yuan, Timothy J Koh, Lin Chen, Robert P Mecham, Luisa A Dipietro

2020-Current year OA Pubs

MFAP5, also known as microfibrillar-associated glycoprotein-2 (MAGP2), may influence parameters of skin wound healing related to scar formation. To further elucidate its role in skin wound healing, we assessed skin wound repair in Mfap5

Meta-Analysis Of The Spatial Distribution And Composition Of Plastic Macro-Debris In Indonesia, Max R. Kelly, Muhammad Reza Cordova, Susan Jobling, Richard C. Thompson

School of Biological and Marine Sciences

Plastic pollution is recognised as a global environmental problem with Indonesia identified as a major contributing source. However, a comprehensive understanding of pollution patterns remains hindered by fragmented data and methodological inconsistencies across studies. This study synthesises data from 44 peer-reviewed publications, spanning 68 field locations and 328 individual study sites across 19 provinces, to map the spatial distribution and composition of plastic macro-debris in Indonesia. We identified plastic bags, plastic food packaging, and plastic bottles as the three most prevalent item types, occurring as top three ranked items in 65 %, 63 %, and 40 % of field locations, …

Gpu-Accelerated Effective Hamiltonian Calculator, Abhishek Chakraborty, Taylor L. Patti, Brucek Khailany, Andrew N. Jordan, Anima Anandkumar

Mathematics, Physics, and Computer Science Faculty Articles and Research

Effective Hamiltonian calculations for large quantum systems can be both analytically intractable and numerically expensive using standard techniques. In this manuscript, we present numerical techniques inspired by Nonperturbative Analytical Diagonalization (NPAD) and the Magnus expansion for the efficient calculation of effective Hamiltonians. While these tools are appropriate for a wide array of applications, we here demonstrate their utility for models that can be realized in circuit-QED settings. Our numerical techniques are available as an opensource Python package, qCHeff, which is available on GitHub (https://github.com/ NVlabs/qCHeff) and PyPI (https://pypi.org/ project/qcheff/). We use the CuPy library for GPU-acceleration …

There Is No Obstruction To A Euclidean Proof For The Fourth Postulate, José Gil-Férez, Piotr Błaszczyk, M. Andrew Moshier, Alberto Naibo, Jean-Michel Salanskis

Mathematics, Physics, and Computer Science Faculty Articles and Research

In Gil-Férez et al. (2025), we presented a proof of Postulate 4 using purely Euclidean techniques, against which Blåsjö (2025) raised several objections. In this note, we offer linguistic, textual, historical, and mathematical evidence that demonstrate that all these objections are baseless.

Tolkien Among The Theologians (2025) Edited By Austin M. Freeman, Tom Emanuel

Journal of Tolkien Research

Book review, by Tom Emanuel, of Tolkien among the Theologians (2025), edited by Austin M. Freeman

The Tax Adviser, Volume 3, Number 10, October 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Litigation Awards And Expenses: Tax Consequences To Defendants And Plaintiffs, John D. Brockhouse, Jacob R. Brandzel

Tax Adviser

No abstract provided.

Final Accumulation Trust Regulations: Explained, Evaluated And Exemplified, Bernard Barnett

Tax Adviser

No abstract provided.

The Loop That Eats Itself: Fast Fashion And The Myth Of Accessible Sustainability, Christie Westby

Sustainable Supply Chain Management

This chapter examines fast fashion as a self-reinforcing system driven by speed, consumption psychology, and misaligned incentives, arguing that true sustainability requires slowing supply chains and redesigning governance rather than simply buying “better” products.

How Native Landscaping And Irrigation Can Conserve Water In Mediterranean Climates, Samuel Carlson

Sustainable Supply Chain Management

This paper explores how using native plants and proper irrigation can lead to sustainable water management in Mediterranean climates, and reinterprets water scarcity as a supply chain issue. Touching on growing populations, climate change, and water pollution, it examines international case studies from Chile, Egypt, and Spain to compare domestic examples at multiple California universities.

Sustainability In Global Shrimp Supply Chains, Michael Behr

Sustainable Supply Chain Management

This chapter explores sustainability challenges within the global shrimp supply chain, comparing the environmental impacts of wild-caught shrimp trawling and shrimp aquaculture. While trawling has historically met global demand, its high levels of bycatch and damage to marine ecosystems make it increasingly incompatible with modern environmental standards. In response, aquaculture now supplies more than half of global shrimp production and is becoming a preferred sourcing option for major buyers.

From a supply-chain perspective, the chapter examines how trade dependence, regulatory pressure, and ESG commitments are shifting procurement strategies toward farmed shrimp. Using examples from large retailers, it shows how buyer-driven …

From Spark To Agency: Metalinguistic Awareness, Investment, And Liberatory Autonomy In Introductory And Honors Intermediate Spanish And Intermediate Italian At Cod, Brian Kapustka

Faculty and Staff Scholarship

This field experience capstone documents the application of sociocognitive, reflective, and equity-oriented pedagogy across multiple Spanish and Italian instructional contexts at the College of DuPage, a large and diverse community college. Grounded in applied linguistics frameworks including sociocognitive second language acquisition (Atkinson, 2011), learner motivation and identity through the L2 Motivational Self System (Dörnyei, 2009), the inseparability of cognition and emotion in second language learning (Swain, 2013), learner autonomy and postmethod pedagogy (Kumaravadivelu, 2002; 2003), learner investment (Darvin & Norton, 2015), willingness to communicate as a volitional process (MacIntyre, 2007), and transformative learning (Mezirow, 2000), the project examines language learning …

Assessing A Model Of Customer Rage: Does Customer Entitlement Moderate Relationships Between Rage Emotions, Expressions And Behaviors?, S. Mostafa Rasoolimanesh, Martin Gannon, Babak Taheri, Josip Mikulić

Research outputs 2022 to 2026

Across travel and tourism services research, studies investigating “customer rage” typically prioritize the direct point-of-consumption, often within airport, airline, or hotel contexts. However, the sector is awash with intermediaries (e.g., travel agencies, insurance brokers, booking platforms), which serve as primary points-of-contact capable of shaping customer expectations. Accordingly, the consequences of service failure therein are nuanced and complex. Yet, extant research often portrays service failure as unilateral (i.e., solely the firm in question’s responsibility), overlooking one core demand-side characteristic: the customer’s sense of entitlement. Thus, while this study draws upon the Iranian travel agency setting (as a service intermediary) to assess …

Liminal Arts And Business: An Autoethnographic Analysis Of A New Arts Venture In An Entrepreneurial Startup Accelerator Program, Jill Schinberg, Rebecca A. Ferrell, Dan Sandfelder

Journal of Arts Entrepreneurship Education

In this study, we explored the intersection of performing arts and entrepreneurship through an autoethnographic study of a new arts venture, theLAB*, which participated in the Von Allmen Center for Entrepreneurship's accelerator program at the University of Kentucky. In creating theLAB*, we investigated the feasibility of establishing a dance-forward performing arts presenting organization within a profit-driven entrepreneurial ecosystem. As a multi-generational team of arts managers, we analyzed the experience utilizing scenario-planning and the DIEP (Describe, Interpret, Evaluate, Plan) model of reflection to assess the challenges and benefits of participating in this environment. Key findings reveal a significant disconnect between the …

Investigating Ionic Liquid (Il)-Based Electrolytes In Li-Co2 Battery Performance, Kaden T. Gammon

Mechanical Engineering and Materials Science Independent Study

This report discusses the results of an independent study that investigates the impact of ionic-liquid (IL) based electrolytes on Li-CO₂ battery performance. Three electrolytes were compared in this study at two temperatures: room temperature and 60 °C. The electrolytes tested were BMIM-DMSO (an IL-based electrolyte), TEGDME, and DMSO. The results indicate that the IL-based electrolyte enables better electrochemical reactions and achieves a higher discharge capacity than the other two electrolytes. This study also compared cathodes with different catalysts, emphasizing the importance of catalyst choice. The comparison showed that bismuth oxide combined with Vulcan carbon may serve as a strong catalyst …

A Multi-Factor Quantum-Resistant And Privacy-Preserving Authentication Protocol For Decentralized Systems, Ahmed Kh. Zamil, Ammar D. Jasim

Mesopotamian Journal of CyberSecurity

This paper presents a Quantum-Resistant and Privacy-Preserving Authentication Protocol (PPAP) designed for decentralized systems. PPAP integrates lattice-based cryptographic primitives, particularly Module-Lattice Key Encapsulation Mechanisms (ML-KEM), addressing both quantum computing threats and stringent privacy requirements. The protocol introduces advanced identity masking techniques and a multi-factor authentication layer employing Cheon-Kim-Kim-Song (CKKS) homomorphic encryption, enabling secure and privacy-aware authentication that supports approximate knowledge-based factors such as biometrics and handwritten signatures. Rigorous formal analysis, including cryptographic proofs and automated verification using the Tamarin Prover, validates PPAP's resilience against classical and quantum adversaries, as well as common security threats such as replay attacks, impersonation, and …

Effects Of Supplemental Led Lighting And Biofertilizer On Yield And Fruit Quality Of Japanese Strawberry Cultivars In Indonesia, Reginawanti Hindersah, Febby Fitriyani, Kenji Endo, Masakazu Nakayama, Syariful Mubarok, Gita Bina Nugraha

Jurnal Kultivasi

Growing strawberries in soilless substrates in the greenhouse relies on fertilizers and supplemental light to boost yield and fruit quality. The research evaluated the properties of the biofertilizer and its effectiveness on the yield of Japanese strawberry cultivars Nanatsuboshi and KS-75 under controlled greenhouse conditions, with and without light-emitting diodes (LED) as supplemental light. The cell viability and plant-growth-promoting properties of a liquid consortium biofertilizer consisting of nitrogen-fixing bacteria and phosphate-solubilizing microbes, were characterized. Laboratory analysis confirmed the biofertilizer's composition, and a greenhouse experiment using a completely randomized design tested treatments of biofertilizer, LED, and their combination. The biofertilizer contained …

Enhancing Advanced Persistent Threat Detection With Federated Learning And Neural Networks For Secure Cloud Computer Environment, Baydaa Flayyih Hasan, Wafaa Ayoub Kassara, Bushra Raad Zahi

Mesopotamian Journal of CyberSecurity

Rapid internet expansion and global cloud storage use have heightened the risk of stealthy, persistent, multi-stage Advanced Persistent Threats (APTs). Distributed and resource-limited cloud environments make identifying these stealthy and dynamic threats difficult for traditional Intrusion Detection Systems (IDSs). This paper present FedNN-APT, a Federated Learning (FL) and hybrid Neural Network (NN) APT detection system to overcome these difficulties. High detection accuracy and distributed, privacy-preserving training over several cloud devices are achieved by this approach. FedNN-APT integrates Gated Recurrent Units (GRUs) and Convolutional Neural Networks (CNNs) to learn temporal and spatial APT behavior features effectively. The framework trains local models …

Fruit Characteristics Of F1 Nil Sletr1-2 Vary With Parental Background, Imas Mintarsih, Anne Nuraini, Farida, Erni Suminar, Rika Meliansyah, Syariful Mubarok

Jurnal Kultivasi

The Sletr1-2 allele, which reduces ethylene sensitivity in tomatoes, offers a promising approach to extending fruit shelf life by slowing ripening-related metabolism. However, the trait’s success depends on compatibility with the recipient cultivar’s genetic background. This study evaluated fruit characteristics of F1 near-isogenic line (NIL) hybrids carrying Sletr1-2 in the commercial backgrounds ‘Costoluto’, ‘Oxheart’, and ‘Sart Roloise’. The field trial was carried out between May and August 2024 at the Experimental Station of Universitas Padjadjaran, Sumedang, Indonesia, following a randomized complete block design with eight biological replicates for each treatment. The results revealed that fruit characteristics of F1 NIL Sletr1-2 …

A Novel Of Bounded Zeghdoudi Distribution: Estimations, Simulation And Applications, Mohammed Elgarhy, Hanene Hamdani, Laxmi Prasad Sapkota, Ahmed M. Gemeay

Mesopotamian Journal of CyberSecurity

In this article, we introduce a new unit Zeghoudi distribution, which is called the bounded Zeghoudi distribution (BZD), an innovative modification of the Zeghoudi distribution (ZD). This new suggested distribution retains the original ZD’s simplicity while improving modeling flexibility and accuracy for data constrained to the unit interval. The BZD displays numerous significant characteristics, including decreased, left-skewed, right-skewed, and unimodal probability density functions, but the hazard rate function can be J-shaped, U-shaped, and bathtub-shaped. Some important statistical features of the BZD, such as moments, mean, variance, moment generating function, lower and upper incomplete moments, mean residual life, mean inactivity time, …

Honoring Philip Zimbardo: Personal Reflections On A Legacy In Heroism Studies, Zeno Franco, Scott T. Allison, Brian R. Riches

Heroism Science

This article concludes our Special Issue of Heroism Science devoted to honoring the legacy of Philip Zimbardo. Across the preceding contributions, scholars have offered personal reflections, examined his influence on psychology and heroism studies, and discussed the applied interventions of the Heroic Imagination Project. In this closing essay, we situate Zimbardo’s distinctive contributions to psychology and reflect on the cumulative insights of the Special Issue. We then shift to a more personal register, as each of the three authors describes how Zimbardo’s mentorship, vision, personality, and scholarship have shaped our own lives and research trajectories. In doing so, we underscore …

Estate Tax Marital Deduction: Pitfalls, Problems And Planning, Norman R. Milefsky

Tax Adviser

No abstract provided.

Protocols For Antioxidant Testing: A Mini Review Of Common Assays And Approaches, Abdulsalam Halboup, Sameer A. Alkubati

AUIQ Complementary Biological System

Antioxidants play a pivotal role in mitigating damage caused by oxidative stress, which is implicated in aging, inflammation, neurodegeneration, and various chronic diseases. With the growing interest in natural and synthetic antioxidants across nutraceutical, pharmaceutical, and food industries, the need for reliable, reproducible, and standardized testing methods has become increasingly urgent. This mini-review provides a structured overview of the most widely used antioxidant testing protocols, categorized into in vitro chemical-based assays (e.g., DPPH, ABTS, FRAP, metal chelation), cell-based assays (e.g., DCFH-DA for intracellular ROS detection), and in vivo biomarker-based models. Each method’s principle, experimental protocol, advantages, and limitations are critically …

Prevalence Of Giardia Infection: A Cross-Sectional Study In Basra Province, Iraq, Sarah Kamal Naser

AUIQ Complementary Biological System

Giardiasis is a common parasite infection that is seen more frequently than any other parasitic infection worldwide. This infection is especially prevalent in tropical areas and in developing nations that have a poor standard of living and poor health conditions. The Giardia parasite is able to infect people of any gender, as it enters the body by the mouth, passes down the oesophagus, and finally reaches the stomach, where it is not negatively impacted by gastric acids. The goal of this study is to determine the extent to which patients who were treated at Al-Zubair General Hospital in Basra, Iraq, …

Application Of Adversarial Volumetric Cnns To 3d Face Generation Using Latent Space Gaussian Embeddings, Ali Raad Abdulkareem, Marwa Jabberi, Islem Jarraya, Tarek M. Hamdani, Khmaies Ouahada, Adel M. Alimi

Iraqi Journal for Computer Science and Mathematics

Although 3D face generation is extensively studied in computer vision, most existing methods prioritize reconstructing 3D geometry from available 2D or 3D inputs rather than generating novel faces directly from latent representations. To bridge this gap, we present the application of Adversarial Volumetric Convolutional Neural Networks (AVCNN), a tailored adaptation of the vanilla 3D Generative Adversarial Network (3D-GAN), to 3D face generation using latent space Gaussian embeddings. We first assemble a custom 3D facial dataset to provide the requisite facial characteristics and to ensure sufficient coverage of geometric variation across identities. The generator, implemented as a decoder, maps latent space …

Durability Of Alkali-Activated Concretes Under 5% Sulfuric Acid Environment, Celal Karabaş, Anıl Niş

Journal of Sustainable Construction Materials and Technologies

The investigation focused on the resistance to 5% sulfuric acid degradation of the alkali-activated concretes (AAC). The AAC was manufactured using a blended binder of 50% slag and 50% F-type fly ash. The AAC was activated using a blend of 14 M sodium hydroxide and sodium silicate, with a hydroxide-to-silicate ratio of 1/2,5. Six AAC were produced against a 5% sulfuric acid environment, varying the binder amounts (400–500–600 kg/m3) and activator-binder (A/B) ratios (0,45–0,55). The chemical resistance of AAC was evaluated by visual appearance, variation in weight and compressive strengths. The findings pointed out that more gypsum and higher weight …