Digital Commons Network^™

Investigation Of Mono-Allelic Rack1 Deletion Effects On Cell Growth And Pkc Mrna Expression, Ashen Quiambao

Seton Hall University Dissertations and Theses (ETDs)

The µ-opioid receptor is a primary target of clinically used opioids, and RACK1 regulates its transcription by physically interacting with MOR transcription regulator PCBP1 in the cytosol to prevent its nucleus translocation. Two mono-allelic RACK1 knockout cell lines named RACKA and RACKB were generated by the CRISPR-Cas9 technique using WT NMB neuroblastoma cells. As RACK1 also contains a PKC-binding domain, this study aims to evaluate the impacts of mono-allelic deletion on cell growth rates and PKC isoform expression. Although a slight decreased tendency of growth rate in RACKA and RACKB cells was observed when compared to that of WT NMB …

Examining Aba Classroom Paraprofessional Training Methods In New Jersey, Melina Campos

Seton Hall University Dissertations and Theses (ETDs)

In recent years, paraprofessionals have become an integral part of educational teams, particularly in classrooms supporting students with disabilities (Giangreco et al., 2010). Their role has been crucial in ensuring that students received necessary academic and social support. This study evaluated the training provided to paraprofessionals in New Jersey, specifically those working in applied behavior analysis (ABA) classrooms. By surveying paraprofessionals on training that they receive and assessing how training influenced their self-perceived knowledge and skills, the study offered insight into how well-prepared these educators felt to support students with disabilities. A total of 57 participants completed the survey. When …

Integrating The Five As Framework To Enhance Person-Centered Care For Adults Living With Obesity, Alexandra Charles

Electronic Theses and Dissertations 2020 - Present

Obesity has adverse effects on physical health, emotional well-being, and mental functioning. To effectively address this highly prevalent and multifaceted condition, the use of a structured, evidence-informed framework is essential to support providers in delivering consistent, person-centered care for individuals living with obesity. The Five As is a powerful yet not commonly implemented framework in many primary care practices. The Five As framework (Ask, Assess, Advise, Agree, Assist) offers a structured model to guide clinicians in delivering consistent, supportive, and transformative care for individuals with obesity.

The goal of the project was to implement a timely and cost-effective protocol/tool that …

Impact Of Postoperative Intraocular Pressure Spikes On Outcomes Following Goniotomy: A Comparative Study Of Surgical Techniques, Wesam S. Shalaby, Steven L. Chang, Julia Yu, Teresa Horan, Sagar Shah, Shahin Hallaj, Marlene Moster, Reza Razeghinejad, Daniel Lee, Michael Pro, Aakriti Shukla, Ping Huang, Jonathan S. Myers, Tina Xia, Dilru Amarasekera

Wills Eye Hospital Papers

AIM AND BACKGROUND:To compare postoperative intraocular pressure (IOP) spikes and 1-year surgical success among goniotomy procedures: Kahook Dual Blade (KDB), OMNI, bent ab interno needle goniotomy (BANG), and gonioscopy-assisted transluminal trabeculotomy (GATT).

MATERIALS AND METHODS: This single-center, retrospective chart review included glaucoma patients ≥18 years, who underwent goniotomy from January 2021 to December 2022 with ≥3 months of follow-up. Primary outcomes were IOP spikes (≥10 mm Hg increase within 3 months) and 12-month surgical success (≥20% IOP and/or ≥1 medication reduction without further surgery). Secondary outcomes included IOP and medication changes.

RESULTS: Among 247 eyes (107 KDB, 63 OMNI, 77 …

Analysis Of Leakage In Nearshore Pipelines Using Fitness For Service Method To Ensure Mechanical Integrity Based On Api-579 Level 3, Elriandri Elriandri, Dedi Priadi

Journal of Materials Exploration and Findings

The Fitness for Service (FFS) analysis is performed as a quantitative assessment to evaluate the integrity condition of a pipeline. Essentially, FFS assessment helps determine whether equipment components can operate safely despite existing deficiencies. This evaluation is carried out using the Finite Element Method (FEM). In the case of an underwater pipeline that experiences leak due to anchor pull at the flange connection, it undergoes plastic deformation and is lifted approximately 1 meter. As a mitigation step, inspection and repairs have been carried out by the company. Subsequently, modeling is performed to reconstruct the deformation process of the pipeline. Then, …

Transient Neuromonitoring Changes And Delayed Vertebrobasilar Infarction Following Anterior Cervical Discectomy And Fusion: Illustrative Case, Jacob M. Chaisson, Jack A. Leoni, Ellery A. Hayden, Gabriel C. Tender, Amit K. Bhandutia

School of Medicine Faculty Publications

BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is a common spinal procedure with a well-established safety profile. While direct vertebral artery injury is rare and typically recognized intraoperatively, delayed posterior circulation stroke is an even less common but major complication. In patients with risk factors for vascular disease, vascular stress from surgical manipulation may predispose them to thromboembolic events that are not immediately apparent. Transient intraoperative neuromonitoring (IONM) changes may represent early, underrecognized indicators of such vascular compromise. OBSERVATIONS: The authors present the case of a 61-year-old male who underwent elective three-level ACDF for degenerative cervical myelopathy. During cage placement, …

Cv: Deborah Augsburger (Literacy), Deborah Augsburger

Education Department Faculty Curricula Vitae

No abstract provided.

Cv: Jung Kim (Literacy), Jung Kim

Education Department Faculty Curricula Vitae

No abstract provided.

The Lived Experiences Of African American Child Sexual Abuse Survivors And Their Relationships With The Perpetrators, Anita Joyner

Walden Dissertations and Doctoral Studies

Child sexual abuse (CSA) can be detrimental to survivors well into adulthood and can affect the relationships of everyone with whom they are involved. Knowing the perpetrator is a determining factor in the equation and is associated with increased odds of behavioral health challenges among survivors. This is especially true within African American communities, where cultural violence results in an increased level of trauma. The purpose of this qualitative study was to examine the lived experiences of African American CSA survivors and their relationships with the perpetrators. As part of the phenomenological design, data were collected through semi-structured interviews with …

Early Depression Screening In Adults With Opioid Use Disorder, Ekaterina Versace

Walden Dissertations and Doctoral Studies

Abstract This Doctor of Nursing Practice project involved the development and quality appraisal of a clinical practice guideline (CPG) for early depression screening in adults with opioid use disorder (OUD), addressing the absence of standardized, evidence-based screening protocols in addiction treatment settings. Guided by the practice-focused question of whether existing evidence supports the development and evaluation of such a guideline using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument, a systematic synthesis of 35 research articles was conducted, with 15 high-level studies informing guideline development. A multidisciplinary panel of four experts evaluated the CPG using the …

Race, Fear Of Falls, Built Environment And Physical Activity In Older Adults With Cancer, Kristen Fessele

General Submissions: Community and Population-based Materials

Motivation for older adults with cancer (OAC) to engage in physical activity (PA) during and after cancer treatment may be limited by many factors. OAC may be affected by persistent symptoms limiting PA capability such as fatigue, pain and dyspnea, or lack safe home or neighborhood spaces to engage in activity. Fear of falling (FOF) is a major concern among OAC and may decrease PA and life-space mobility. To understand how OAC perceptions of cancer treatment, FOF and their local built environment (BE) influence PA behaviors, we partnered with ResearchMatch.org to recruit a sample of 19 people with a history …

Targeting Kinesin Family Member 20a Sensitizes Stem-Like Triple-Negative Breast Cancer Cells To Standard Chemotherapy, Yayoi Adachi, Weilong Chen, Cheng Zhang, Tao Wang, Nina Gildor, Rachel Shi, Haoyong Fu, Masashi Takeda, Qian Liang, Fangzhou Zhao, Hongyi Liu, Jun Fang, Jin Zhou, Hongwei Yao, Lianxin Hu, Shina Li, Lei Guo, Lin Xu, Ling Xie, Xian Chen, Chengheng Liao, Qing Zhang

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC), being both aggressive and highly lethal, poses a major clinical challenge in terms of treatment. Its heterogeneity and lack of hormone receptors or HER2 expression further restrict the availability of targeted therapy. Breast cancer stem cells (BCSCs), known to fuel TNBC malignancy, are now being exploited as a vulnerability for TNBC treatment. Here, we dissected the transcriptome of BCSCs and identified kinesin family member 20A (KIF20A) as a key regulator of BCSC survival and TNBC tumorigenesis. Genetic depletion or pharmacological inhibition of KIF20A impairs BCSC viability and tumor initiation and development in vitro and in vivo. …

Itpr1 Autoantibody-Associated Autoimmunity As A Cause Of Newly Emerging Cognitive Decline Mimicking Alzheimer's Disease: Case Report And Brief Review Of The Literature, Nicolas Kunath, Hermod Arne Bollandsås Ramfjord, Elisabeth Volden Kvisvik, Marton Konyves-Kolonics, Gøril Rolfseng Grøntvedt, Irina I Serysheva, Lars Komorowski, Brigitte Wildemann, Sven Jarius

Faculty, Staff and Student Publications

Background: Since its first description in 2014, anti-inositol 1,4,5-trisphosphate receptor type 1 (ITPR1, also termed IP3R1) autoimmunity has been recognized as causing a clinically heterogeneous spectrum of symptoms. While first described in patients with autoimmune cerebellar ataxia, this facultative paraneoplastic disease has been associated also with peripheral neuropathy, dysautonomia, sleep disorders, neuropsychiatric/psychotic symptoms, and cognitive decline.

Methods: Retrospective case study.

Results: We report the case of a 58-year-old patient who was admitted with acute confusion, rapidly progressive cognitive decline, and hallucinations. A history of mild cognitive impairment over several years and low cerebrospinal fluid (CSF) amyloid beta-42 and elevated CSF …

Holistic Support And Development: Collaboration Between Residence Life And Faculty On Short-Term Education Abroad Programs, Kendra Sherman

Seton Hall University Dissertations and Theses (ETDs)

Short-term education abroad programs are designed to increase students’ intercultural competencies, expose them to new cultures and languages, prepare them for future employability, and further their academic development (Castiello-Gutiérrez & Gozik, 2022; Yao, 2021). While education abroad programs may result in strong benefits for students, they are not without their challenges when it comes to facilitating and managing them. Both the faculty who lead these programs and the students who participate in them face challenges respective to their experiences abroad. Many researchers emphasize collaboration between student affairs and academic affairs to alleviate these challenges, but no one office is identified …

Intouch Week Of December 15, 2025, New York Medical College

InTouch

• Record Numbers, Remarkable Research Define 30th Medical Student Research Forum
• Wellness Ambassador Program Welcomes New Student Leaders
• New Test Could Revolutionize Lyme Disease Diagnosis
• Meal Plan Launches Through Vemos Pay
• Off Campus, On Craft: Jeanne Chamas Keeps the Department on Track and the Community in Step

Current Concepts: Subclinical Dermatologic Conditions That Increase Surgical Site Infection Risk In Hand Surgery, Ambrose Loc Ngo, Truong Ho, Niki Gharavi Alkhansari, Hima Patel, Allison Tang, Charles Orth

Student Publications

Background

Hand surgery, despite being a clean and elective surgery, excluding trauma, still poses challenges such as functional impairment, risk of healing, and infection recovery. Certain conditions, such as psoriasis or dermatitis, can trigger some serious instances of trauma.

Objective

This narrative review aims to map how these conditions contribute to surgical-site infections (SSIs), delayed healing, scarring/contracture, and functional or aesthetic impairment. Additionally, we hope to propose practical, interdisciplinary recommendations for preoperative screening and perioperative management tailored to elective hand surgery.

Conclusion

From this review, we saw an even bigger risk arises from the Koebner phenomenon. Specific disorders can exacerbate …

Measuring And Modeling Nonlinear Vibrations In Structures With Mechanical Joints, Suzanna Gilbert

Theses and Dissertations

Many assembled structures have bolted or riveted joints. Aside from providing a convenient method of assembly, mechanical joints have an important effect on the structure's dynamic response to its environment. Friction and microslip within the joints help to damp out unwanted vibration. However, the joints also introduce nonlinearity into the response. Most notably, the natural vibrational modes of the structure no longer have constant natural frequencies and damping ratios. Rather, they shift as a function of vibration amplitude. Several methods exist to characterize the dynamics of nonlinear systems, yet they are generally validated on simple benchmark structures, and many still …

Beyond Barriers: Improving Employment Outcomes For Young Adults On The Autism Spectrum, Kendra L. Cope

UNLV Theses, Dissertations, Professional Papers, and Capstones

Young adults with autism spectrum disorder (ASD) continue to face persistent barriers to employment, often stemming from challenges in communication, adaptability, and multitasking. Virtual reality (VR) has emerged as a promising tool to strengthen these employment skills through immersive, low-stress practice. This study evaluated a VR-based intervention using Floreo VR modules, guided practice, and performance feedback to enhance job readiness among high school students with ASD. A multiple-probe design across three skill domains: multitasking, handling interruptions and changes, and workplace communication to examine skill acquisition and maintenance with three students with ASD aged 16–18. Data from task-analysis checklists, interobserver agreement …

Demographic Similarity, Psychopathy, And Perceived Inherent Value: An Investigation Of Factors Influencing Moral Decision Making, Ashley Michelle Poston

UNLV Theses, Dissertations, Professional Papers, and Capstones

The present study experimentally manipulated the demographic characteristics of the subjects of moral dilemmas such that they were 20%, 40%, 60%, and 80% demographically similar to participants. Participants rated each of these individuals on a novel measure of perceived inherent value, the Perceived Inherent Value Scale (PIVS) and responded to a series of moral dilemmas using the Consequences, Norms, and preference for Inaction (CNI) model of moral decision making where the subjects of the moral dilemmas were the 20%, 40%, 60%, and 80% similar individuals. Participants rated individuals who were more demographically similar to themselves as having greater perceived inherent …

A Phenomenological Study Of The Experiences Of Adolescents With Emotional Behavioral Disorders In High School, Melissa Lawson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Adolescents with emotional and behavioral disorders (EBD) face significant challenges in forming and maintaining peer relationships, yet their voices and lived experiences remain largely absent from the research literature. This phenomenological study explored how high school students with EBD perceive the impact of peer relationships on their academic, social, and emotional experiences at school. Using Moustakas's (1994) modification of the StevickColaizzi-Keen method, the researcher conducted in-depth semi-structured interviews with seven high school students (ages 15-18) who had received special education services under the EBD eligibility category for 5 to 10 years in a large, urban southwestern school district.

Five universal …

Integrating Classical Singing Techniques To Aid Natives In Performing Traditional Tongan Folk Songs Of The Late Queen Sālote Tupou Iii, Pauline 'Ofa Vaitāfā Tamale

UNLV Theses, Dissertations, Professional Papers, and Capstones

This document introduces a structured, classical vocal approach to equip native singers with healthier performance techniques and enable anyone in the music world to perform the art songs derived from the poetry and compositions of Queen Sālote Tupou III. The objective of this project is to provide performers, particularly those with a native proficiency, with classical techniques to perform this music with vigor while circumventing vocal fatigue caused by the linguistic, dialectal, and cultural demands inherent in the repertoire. Queen Sālote Tupou III (1900–1965) reigned for nearly 50 years – the longest of any Tongan monarch – and left an …

Objective Vs. Perceived Maternal Smartphone Use And Observed Mother-Infant Interaction Quality, Alison K. Ventura, Lara N. Wolfers, Sarah M. Coyne, Rachel Pfafman, Sabrina Uva, Karla I. Ceja Almontes, Aniruddha S. Shinde, Adam M. Galovan, Brandon Mcdaniel

Health Services and Informatics Research

Introduction:

Prior research links maternal smartphone use to reduced sensitivity and responsiveness to infant cues, but emerging evidence suggests that mothers' perceptions of their smartphone use - such as feelings of empowerment or distress - may also shape the quality of mother-infant interactions. This study examined how both objective and perceived smartphone use related to mother-infant interaction quality in naturalistic settings.

Method:

Participants were 147 mother-infant dyads from a longitudinal study of smartphone use and infant development. When infants were 2 months old, mothers completed 5 days of ecological momentary assessment (EMA), reporting time spent with their infant, perceived smartphone-related …

Gender Equality Discourse: A Japanese Context, Gabriel Eweje, Hitomi Toyosaki, Kazunori Kobayashi, Sitong Michelle Chen, Masahiro Hosoda

Research outputs 2022 to 2026

Purpose – This review paper aims to critically examine the discourse on gender equality in Japan, focusing on its socio-cultural, economic and political dimensions. By synthesising existing literature, it provides a comprehensive understanding of the complexities and barriers that influence the gender equality debate in Japan, while identifying gaps and opportunities for future research and specifying where practice can be recoupled to policy. Design/methodology/approach – An integrative literature review was conducted across four key institutional domains – markets, government/public sector, families and education – analysed at the macro, meso and micro levels. The synthesis is integrative rather than exhaustive, prioritising …

The Evolution Of Southern Ocean Net Primary Production In A Changing Climate: Challenges And Opportunities, Alessandro Tagliabue, Thomas Ryan-Keogh, Alex Baker, Thomas S. Bibby, Chris Follett, Maeve C. Lohan, Alberto Naveira-Garabato, Daniel J. Mayor, Angela Milne, C. Mark Moore, Simon Ussher

School of Geography, Earth and Environmental Sciences

Net primary production in the Southern Ocean plays a critical role in governing ecosystem production, the biological carbon pump, and global biogeochemical cycles. Recent work has advanced our understanding of novel factors regulating Southern Ocean net primary production and the regional physiological adaptations employed by Southern Ocean phytoplankton in terms of their photosynthetic strategies and resource acquisition. Here we assess trends in Southern Ocean net primary production from different remote sensing algorithms and bgc-Argo floats to compare them to the latest Earth System Models used to forecast future changes under three different future climate scenarios. Overall, remote sensing and bgc-Argo …

Opinions Of The Uk General Public And Stroke Survivors In Using Artificial Intelligence And ‘Opt-Out’ Models Of Consent In Medical Research: A Qualitative Study, William Heseltine-Carp, Mark Thurston, Michael Allen, Daniel Browning, Megan Courtman, Aishwarya Kasabe, Emmanuel Ifeachor, Stephen Mullin

Peninsula Medical School

Background Artificial intelligence (AI) in healthcare often requires large, confidential clinical datasets. However, a recent UK government survey revealed that 20–40% of the public remain sceptical of its use in health research due to concerns about data security, patient–practitioner communication and commercialisation of data. A greater understanding of public attitudes is therefore needed, particularly in the context of stroke research.In this article, we describe the patient and public involvement work undertaken for the AI-Based-Stroke-Risk-fActor-Classification-and-Treatment (ABSTRACT) project, which aims to train AI models to predict future stroke risk from the electronic health records of 1 18 736 patients.Aims We aimed to …

Breaking Barriers: Understanding Factors Constraining Women’S Career Choices And Progression In The South African Construction Industry, Abimbola Olukemi Windapo, Olugbenga Timo Oladinrin, João Alencastro, Dineo Mbekwa, Christiana Ekpo, Muhammad Qasim Rana, Amanda Filtane

School of Art, Design and Architecture

Purpose – This paper examines the barriers constraining women's career choices and progression within the South African construction industry. Design/methodology/approach – The study employed a mixed-methods research approach, utilizing a questionnaire survey of construction industry workers listed in the Construction Professions Register, the Builders Collective and the Housing Assembly Organization. It also used interviews to validate the quantitative data. The data collected were analysed using descriptive and inferential statistics, including factor analysis. Findings – The study found that 39 of the 46 barriers identified have normalized values greater than 0.5 and, therefore, are classified as critical. From a ranking perspective, …

A Less Than Ideal Journey: The Introduction Of Commercial Smart Card Ticketing For Local Bus Services In England, Jon Shaw, Iain Docherty, Andrew Seedhouse, Alison Rumbles

School of Geography, Earth and Environmental Sciences

Purpose: In the broader context of the pursuit of a more sustainable transport policy in the United Kingdom, the paper explores issues that emerged during the instigation, development and implementation of national smart ticketing policy for England.Design/methodology/approach: The primary empirical information in this paper was derived from 51 semi-structured interviews with 61 key stakeholders in the process of developing and implementing smart ticketing policy. Participants were identified through a purposive sampling approach designed to engage respondents because of the position they occupy and the quality of information they can provide.Findings: Difficulties emerged in the partnership approach to policy delivery made …

Risky Decision Making Among Adolescents, Ziad Ahmed Hussein, Ashraf Muwafaq Flaiyah

Alustath Journal for Human and Social Sciences

Risk decision-making refers to choices made under uncertain circumstances where the potential negative consequences are high. Adolescents are often at a crossroads during this stage, where the rush towards reward and external influences, such as peer pressure and environmental pressures, can greatly influence their decisions. The current research aims to: • Identify risky decision-making among adolescents. For this purpose, the researchers built a tool to measure risky decision-making among adolescents based on Albert Bandura›s observational learning theory (Bandura, 1976). The scale consisted of (30) items that were applied to the research sample of (400) male and female students from secondary …

Self-Reference Effect On Memory In Early Childhood, Haneen Ali Jalab, Intisar Hashim Mahdi

Alustath Journal for Human and Social Sciences

The current research aims to identify: 1. The effect of self-referencing on memory among children in early childhood according to the variables of: a. Age (3, 4, 5, 6 years). b. Gender (male–female). 2. The significance of statistical differences in the effect of self-referencing in early childhood concerning: a. Age (3, 4, 5, 6 years). b. Gender (male–female). The research sample consisted of 200 children (100 boys and 100 girls) selected from nurseries, kindergartens, and primary schools in Baghdad, with 50 children for each age group. The researcher adopted the tool developed by Cunningham et al. (2014) to measure the …

The Development Of Children's Beliefs About The Purpose Of Life Events, Amal Salem Shamkhi, Ghada Ali Hadi

Alustath Journal for Human and Social Sciences

The current research aims to identify: 1- Children's beliefs about the purpose of life events according to the variables: A- Age (5, 6, 7, 8, 9, 10) years. B- Gender (males - females) 2- Statistically significant differences in children's beliefs about the purpose of life events according to the variables: A- Age (5, 6, 7, 8, 9, 10) years. B- Gender (males - females). The current research sample included (240) boys and girls from kindergartens and government primary schools in Dhi Qar Governorate, aged (5, 6, 7, 8, 9, 10) years, with (40) boys and girls for each age group, …