Digital Commons Network^™

Rewiring The Immune Response In Lung Cancer: Current Progress In Bispecific Antibodies, Car-T Therapy, And The Rise Of In Vivo Car-T Platforms, Jianguo Wen, George R Blumenschein, Hong Ma

Faculty, Staff and Student Publications

Lung cancer remains the leading cause of cancer mortality worldwide and continues to impose a major clinical burden, particularly in advanced non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Although targeted therapies, antiangiogenic agents, immune checkpoint inhibitors, and antibody-drug conjugates have improved outcomes in selected patients, durable responses remain limited by primary and acquired resistance. Here, we comprehensively review recent progress in immunologically oriented therapeutic strategies for lung cancer, focusing on bispecific antibodies, chimeric antigen receptor (CAR) T-cell therapy, and emerging in vivo CAR-engineering modalities. We further elaborate on the clinical rationale, latest translational and early clinical evidence, …

A Hybrid Vit-L/32-Maxvit-L Architecture With Adaptive Gated Fusion For Multiclass Gastrointestinal Disease Detection And Multi-Method Post-Hoc Explainability

Faculty, Staff and Student Publications

Introduction: Accurate detection of gastrointestinal diseases from endoscopic images remains challenging due to substantial inter-class similarity, intra-class variability, and heterogeneous lesion presentation. While convolutional neural networks (CNNs) effectively capture fine mucosal textures, their limited receptive field restricts global contextual reasoning. Conversely, transformer architectures model long-range dependencies but may underrepresent localized structural detail.

Methods: This study proposes a dual-branch hybrid transformer framework that integrates global token-level reasoning from ViT-L/32 with hierarchical spatial modeling from MaxViT-L. An adaptive gated fusion mechanism is introduced to dynamically regulate the relative contribution of local and global representations on a per-sample basis, enabling content-aware cross-scale integration. …

Global-Local Feature Fusion: A Robust Hybrid Deep Learning Model For Multiclass Brain Tumor Classification With Grad-Cam++ Interpretation, Zhongming Zhao

Faculty, Staff and Student Publications

Background: Accurate classification of brain tumors in MRI scans is critical for effective clinical decision making, yet manual assessment is labor-intensive and subject to variability. Although deep learning models, particularly CNNs and Transformers, have shown potential, each architecture alone has limitations: CNNs excel at local feature extraction but lack global context awareness, while Transformers capture global relationships but may overlook fine-grained details.

Objectives: To develop a hybrid Transfer Learning-Transformer model that integrates CNN-driven local feature modeling with Transformer-based global reasoning to enhance multi-class brain tumor classification.

Methods: The proposed workflow comprises three stages: (1) benchmarking standalone CNN (ResNet50, VGG19, ConvNeXtBase, …

Genetic Variants Associated With Sjögren’S Disease Subtypes Stratified By Clinical Feature, Junichi Iwata

Faculty, Staff and Student Publications

Introduction: Sjögren's disease (SjD) is a chronic autoimmune disorder characterized by dry mouth (xerostomia) and dry eyes (xerophthalmia) due to inflammation in exocrine glands, particularly the salivary and lacrimal glands. The condition presents a wide variety of clinical features, suggesting that it may involve heterogeneous conditions without a clear boundary. Although genome-wide association studies (GWAS) have identified several genetic variants associated with SjD, their roles in SjD pathogenesis remain unclear.

Methods: In this study, we aimed to identify single-nucleotide polymorphisms (SNPs) associated with SjD by categorizing patients based on four diagnostic markers: anti-Ro/SSA and anti-La/SSB antibodies, IgG levels, and lymphocyte …

Towards Acoustic Bioindicator Integration In Ai-Based Wildfire Monitoring: A Systematic Review, Sabah Mustafa, Mahsa Mohaghegh, Iman Ardekani, Abdolhossein Sarrafzadeh

Electrical & Computer Engineering Faculty Publications

Wildfires are becoming more frequent, severe, and long-lasting, driving rapid growth in sensor-based and artificial intelligence (AI)-enabled systems for early detection and risk assessment. This article presents a systematic literature review, based on 169 studies screened from 7511 records, of wildfire monitoring approaches using satellite and aerial remote sensing, fixed cameras, wireless sensor networks, and Internet of Things (IoT) platforms combined with machine learning (ML) and deep learning (DL) models for ignition detection, fire-weather indices, spread prediction, and burned-area mapping. The review organizes existing work by sensing modality, spatial and temporal scale, learning task, model type, and deployment architecture, and …

Performance Assessment And Design Improvements For An Urban Coastal Detention Basin Under Intensifying Rainfall Extremes, Imiya Mudiyanselage Chathuranika, Agyare Asante, Faeghe Borhani, Xixi Wang, Mujde Erten-Unal, Dalya Ismael

Civil & Environmental Engineering Faculty Publications

Coastal urban areas are increasingly exposed to flooding driven by more frequent and intense rainfall events, rising sea levels, and expanding impervious surfaces. Norfolk, Virginia, a low-lying coastal city with aging stormwater infrastructure, faces heightened vulnerability to these hydrologic pressures. This study evaluates the hydraulic performance of an existing urban detention basin within the Edgewater–Larchmont catchment under 10-, 50-, and 100-year, 2-h design storms using the U.S. Environmental Protection Agency’s Storm Water Management Model (SWMM). Simulations were conducted for both pre- and post-development conditions to assess changes in peak discharge, storage capacity, and water level dynamics. Results show that urbanization, …

Harnessing Activated Sludge For The Treatment Of Hydrothermal Liquefaction Wastewater: A Proof-Of-Concept Study, Cyrus Li, Jiefu Wang, Meicen Liu, Yi Zheng, Sandeep Kumar, Isamu Umeda, Chandan Mahata, John Norton

Civil & Environmental Engineering Faculty Publications

Although hydrothermal liquefaction (HTL) is the leading technology in converting wet biomass into bioenergy, the treatment of its toxic-laden aqueous phase wastewater presents a major challenge on its path toward commercial viability. This study presents the first-ever assessment of sewage sludge-fed HTL wastewater (SS-HTLWW) treatment and toxic compound removal using municipal activated sludge (AS) by optimizing its cultivation condition. It was found that AS with optimized pretreatment can remove up to 91.2% of the soluble chemical oxygen demand (sCOD) in SS-HTLWW, of which up to 82% can be attributed to biological mineralization and adsorption of sCOD by AS. Conventional bioprocess …

Integrating Self-Organizing Maps And Explainable Artificial Intelligence To Unravel Surface Water-Groundwater Hydrochemical Evolution And Drinking-Water Suitability Controls In A Data-Limited Arid Basin, Hui Tong, Ruizhong Gao, Yinlong Wang, Xixi Wang, Limin Duan, Guoqiang Wang

Civil & Environmental Engineering Faculty Publications

Study region

The Dahei River Basin, located in the semi-arid northern region of China's Great Bend of the Yellow River.

Study focus

This study integrates hydrochemical characterization, stable hydrogen-oxygen isotopes, Self-Organizing Maps (SOM), the entropy-weighted water quality index (EWQI), and explainable ensemble learning (XGBoost-TreeSHAP) to investigate surface water-groundwater evolutionary patterns and identify key hydrochemical contributors to drinking-water suitability in the Dahei River Basin.

New hydrological insights for the region

Waters in the basin are predominantly weakly alkaline and are characterized by HCO₃^--Ca-Mg and HCO₃^--Na facies, indicating the combined effects of carbonate weathering and cation exchange, with …

Adverse Childhood Experiences And Intellectual Disabilities: A Population-Based Comparison, Sarah Hurst, Astrida S. Kaugars

Modern Psychological Studies

Childhood is a critical time for development, and negative experiences during this period may have lasting consequences. Children with intellectual disabilities (ID) are at greater risk for adverse childhood experiences (ACEs) than children without ID. Using data from the 2022 National Survey of Children’s Health (U.S. Census Bureau), we assessed the frequency of ACEs reported based on IDs. Participants were caregivers of 528 children currently diagnosed with an ID and a random sample of 528 children selected from the remaining 49,755 respondents without an ID. As hypothesized, parents of children with ID reported a statistically significant greater number of total …

Context, Cognition And Convictions: Examining Analytic Versus Holistic Thinking In Police Lineup Identifications, Ellie L. Cotten, Benjamin Terry Sharpe Dr, Roy Spina

Modern Psychological Studies

Eyewitnesses have a significant impact on decisions made by the criminal justice system, and incorrect identifications are a leading cause of unjust convictions. Although many studies have examined the effects of individuals' cognitive approaches (analytic versus holistic) on object recognition, little research has explored these effects in relation to facial recognition. Moreover, no research has explored this phenomenon within the context of police lineup procedures. The aim of this study was to address these gaps and investigate whether there are effects of holism and background condition on identification accuracy and confidence in police lineup procedures. Participants (N = 254) watched …

A Hybrid Response Surface Methodology And Machine Learning Framework For Quantifying Effects Of Physicochemical Parameters On Pfas Distribution, Harsh V. Patel, Jazmin Green, Hyoshin Park, Stephanie Luster-Teasley Pass, Renzun Zhao

Engineering Management & Systems Engineering Faculty Publications

Predicting PFAS adsorption across diverse adsorbents and environmental matrices remains challenging because adsorbent physicochemical properties, PFAS molecular descriptors, and operational conditions simultaneously influence adsorption. This study develops and evaluates a unified hybrid modeling framework that integrates Response Surface Model (RSM) with machine-learning algorithms to quantify how six key variables, surface area, Log K_ow, pH_pzc, pK_a, log dose, and log-initial concentration, affect PFAS distribution coefficients (Log K_d). A data set of more than 1000 adsorption observations spanning 15 PFAS compounds, multiple adsorbent types, and a broad operational range was compiled and preprocessed using …

Technological Interventions For Reducing Climate Change Impacts On Health: An Overview Of Future Possibilities, Sujatha Alla, Vijay Kumar Chattu, Bawa Singh

Engineering Management & Systems Engineering Faculty Publications

Globally, over five million deaths annually are attributed to extreme weather events exacerbated by climate change, such as heatwaves, hurricanes, wildfires, droughts, and floods, which create health crises and economic losses. The 2015 Paris Declaration emphasized climate technology mechanisms, including research and development, to enhance resilience and reduce greenhouse gas emissions. Biotechnological advancements have mitigated about 20% of economic losses since the 1960s, highlighting technology’s potential to address climate-induced health risks.

Access To Justice In Indian Country: Empowering Pro Se Criminal Defendants Through Holistic Defense And Resource Creation, Ilse Turner, Johanna Farmer

South Dakota Law Review

The question of the right to counsel for indigent criminal defendants has consumed various courts and academic journals for decades. Part of this question has revolved around the rights of indigent defendants being prosecuted in tribal courts. There has been scholarly attention devoted to the study of the rights of indigent defendants in tribal courts and the impacts of case law and congressional acts on these rights. This Article seeks to expand the scholarly works around indigent defendants in tribal courts and provide tangible solutions tribes can begin to execute without an act of Congress. This Article will discuss the …

Parent Perspectives: Child Attendance In Community Grief Support, Janeene Sanderson

EWU Masters Thesis Collection

Childhood bereavement can affect children emotionally, socially, and developmentally, creating a need for support that is both age-appropriate and grief-informed. This qualitative study explored how parents perceived the impact of community grief support programs for their bereaved children. The study focused on children ages 8–12 who attended a peer support group, grief camp, or similar community-based grief support program after the death of a loved one. Data were collected through parent interviews and reviewed through thematic analysis. Findings showed that parents perceived these programs as meaningful because they created safe spaces where children could feel normal and validated in their …

2026 January, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for January of 2026.

Innovative Sovereignty: California Tribes' Use Of The Nonprofit Corporation, Stephen F. Diamond, Jennifer W. Kuan

South Dakota Law Review

Native American tribes have long sought, but not always received, federal recognition as sovereign Indian Nations. Recognition confers substantial financial and legal benefits including access to federally funded health services, education and housing. Sovereign status allows tribes to pursue business activity. Tribal sovereignty, however, has significant limitations. The recognition process is costly, time-consuming, highly politicized, and often uncertain. Federal law enforcement and health services that should follow recognition are chronically underfunded. We examine the efforts of Indian tribes in California’s Monterey County to use the nonprofit corporation form to establish clear property rights to land. We interview key participants and …

When A Black Man Is In The Principal’S Office: Black Male Leaders Navigating Racialized Spaces, Phillip Smith

GSE Faculty Publications

This study describes the experiences of fourteen Black male principals or heads of school navigating racialized spaces, including the politics of race, and experienced racism in educational settings as well as in school leadership. Data analysis utilized a critical race theory (CRT) and culturally sensitive methodological and interpretive framework. The data analysis revealed themes associated with identity scrutiny, right to lead, meritocracy and color evasiveness, all falling within the white gaze paradigm. However, the results also suggest a demonstrable pathway for Black leaders to successfully navigate the pitfalls of the white gaze and experienced negative professional and personal reactions to …

Stewart Papers, Beryl, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Rhea Beryl Stewart was a South Dakota educator, writer, and literary leader whose career bridged teaching, creative writing, and public service. Educated at Northern States Teachers’ College and the State University of Iowa, she taught English in Aberdeen, directed secondary English programs, and advised student literary activities before later serving on the South Dakota Board of Education. A prolific poet and essayist, Stewart published widely, received recognition in state and national literary competitions, and held leadership roles in professional writing organizations. The collection contains manuscripts, correspondence, publications, and scrapbooks that document her literary output, professional networks, and contributions to education …

Driving Hawk Sneve, Virginia Papers, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Virginia Driving Hawk Sneve (b. 1933) is a Lakota writer, educator, and historian, recognized for her contributions to Native American literature and cultural preservation. An enrolled member of the Rosebud Sioux Tribe, she was raised on the Rosebud Reservation in South Dakota and pursued a career in education before transitioning to writing. Her literary career began in 1971 with the award-winning Jimmy Yellow Hawk, leading to a prolific body of work that includes fiction, non-fiction, historical studies, and children’s literature. Her impact on Indigenous representation in literature and education has been widely recognized, earning her numerous honors, including the …

Corothers Papers, Lonita, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The Lonita Gustad Corothers Papers document the life and writings of a South Dakota pharmacist whose extensive personal record spans more than six decades. The collection is centered on diaries kept from 1945 to 2010, offering detailed accounts of daily life, family relationships, education, and religious reflection, including her experiences as a pharmacy student at South Dakota State College and observations in the immediate aftermath of World War II. Supplementary materials include indexed timeline notebooks, thematic excerpts, transcriptions with later commentary, and reorganized diary volumes.

Also included is correspondence with her husband, Thomas Corothers, primarily from their courtship and early …

College Of Arts And Sciences Records, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The College of Arts and Sciences at South Dakota State University traces its origins to the General Sciences Course, first offered in 1884. The program later developed into the General Science Division, established in 1924, and became the Division of Science and Applied Arts in 1953. Following the institution’s transition to university status, the division became the College of Arts and Sciences. The College provides instruction in the university’s general education core and offers disciplinary education in the arts and sciences.

The records consist of administrative files, publications, correspondence, reports, committee records, meeting minutes, statistical materials, curriculum records, accreditation files, …

Charles A. Lundquist Papers, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Charles A. Lundquist (1928–2017) was a physicist and space science administrator whose career included research and leadership roles with the U.S. Army, NASA’s Marshall Space Flight Center, and the University of Alabama in Huntsville. Born in Webster, South Dakota, he graduated early from high school in 1945 and enrolled at South Dakota State University, where he earned a Bachelor of Science in engineering physics. He later received a Ph.D. in physics from the University of Kansas in 1953. Lundquist held positions at Pennsylvania State University’s Ordnance Research Laboratory, the Army Ballistic Missile Agency, and NASA’s Marshall Space Flight Center, where …

Driving Hawk Sneve Papers, Virginia, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

This collection documents the career and contributions of Virginia Driving Hawk Sneve, a Lakota writer, educator, and historian from the Rosebud Sioux Tribe. Spanning the 1960s through the 2020s, the collection includes manuscripts, correspondence, research materials, published works, teaching resources, and audiovisual materials that illustrate her work in Native American literature, education, and cultural preservation. Materials trace the development of her fiction and nonfiction writings, including children’s literature and historical works, as well as her roles as a teacher, guidance counselor, editor, speaker, and advocate. The collection provides insight into Indigenous storytelling, representation, and education, and documents Sneve’s national recognition …

Osgoode Syllabus Of Courses And Seminars: 2026 - 2027, Office Of Student Services

Syllabi

No abstract provided.

Young Papers, Gertrude Stickney, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Gertrude Stickney Young was a longtime faculty member at South Dakota State University, educator, writer, and civic leader whose career spanned the early and mid twentieth century. The collection documents her academic work, historical writing, and involvement in university and community organizations through correspondence, clippings, departmental materials, manuscripts, and personal items dating from the late 1920s through the mid 1960s. Materials reflect Young’s contributions to the history of South Dakota State University, her family and regional historical research, and her broader role in South Dakota’s educational and cultural life.

South Dakota Farmer's Alliance Records, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The South Dakota Farmers Alliance Records reflect the early organization of farmers in Dakota Territory during the 1880s in response to declining wheat prices and opposition to railroad monopolies. The collection includes an 1887 address by Alliance president H. L. Loucks, proceedings from an annual convention, and an undated agricultural advertisement, illustrating the Alliance’s advocacy for economic reform and practical agricultural education. Together, these materials provide insight into the leadership, priorities, and strategies of the Farmers’ Alliance during a formative period of agrarian activism in South Dakota.

Schultz Papers, Theodore W., Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Theodore W. Schultz (1902–1998) was a Nobel Prize–winning economist whose work reshaped understanding of agricultural economics, economic development, and human capital. Raised on a South Dakota farm, Schultz’s early experiences with agricultural hardship influenced his lifelong focus on the economic conditions of farmers and the role of education and skills in productivity. After earning advanced degrees from the University of Wisconsin, he held influential academic positions at Iowa State University and the University of Chicago, where he helped establish the university as a leading center of economic thought. Awarded the 1979 Nobel Prize in Economics, Schultz authored numerous foundational works …

Marghab Papers, Vera Way, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

Vera Way Marghab (1900–1995) was a pioneering entrepreneur in the luxury textile industry. Born in South Dakota, she studied piano in New York before co-founding Marghab, Ltd. on the Portuguese island of Madeira in 1933 with her husband, Emile Marghab. Together, they built one of the most esteemed embroidery houses, producing linens celebrated for their craftsmanship, exclusivity, and innovative design. Following Emile’s death in 1947, Vera led the company for nearly four decades, navigating shifts in global markets and political changes in Portugal before closing the business in 1984. Today, Marghab linens remain a benchmark of excellence, with a complete …

Hansen, N. E., Papers, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The N.E. Hansen papers represent a comprehensive archive chronicling the career of Niels Ebbesen Hansen. The collection encompasses a diverse range of materials, including authored articles, bulletins, and circulars from Hansen's tenure at the South Dakota Experiment Station, as well as field notebooks, and ledgers from the South Dakota Horticultural Society.

Contributions from Helen Hansen Loen, Hansen's granddaughter, further enrich the collection with addresses, correspondence, journals, and travel documents, offering a deeper understanding of his professional and personal life. Notable highlights include addresses delivered by Hansen at prestigious events like the International Congress of Genetics in Berlin, underscoring his scholarly …

South Dakota Nurses' Association Records, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Archives Finding Aids

The South Dakota Nurses’ Association (SDNA), founded in 1916 as the South Dakota State Association of Graduate Nurses, has served as the leading professional organization for nurses in the state for more than eight decades. Established in Rapid City with seventeen members and Elizabeth Dryborough as its first president, the association became the 43rd constituent of the American Nurses Association and adopted its current name in 1929. From its earliest accomplishment, drafting and promoting the 1917 Nurse Practice Act that established licensing standards and led to the creation of the South Dakota Board of Nursing, SDNA has shaped nursing regulation, …