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Genetic Adaptations And Malaria Prophylaxis In Sickle Cell Disease: Reducing Morbidity And Mortality, Fuseina Gimballa

Lynchburg Journal of Medical Science

This study examines the relationship between sickle cell disease (SCD) and malaria, focusing on the benefits and risks of the sickle cell trait, complications associated with SCD, and the impact of malaria infection in endemic regions. The paper emphasizes the importance of antimalarial prophylaxis for patients with SCD living in these areas. Evidence suggests a genetic adaptation in populations exposed to malaria, where a β-globin mutation provides partial protection against infection in individuals with the sickle cell trait. Studies consistently show that heterozygous carriers are largely protected from severe malaria, whereas individuals with homozygous SCD remain highly susceptible, resulting in …

Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C

Lynchburg Journal of Medical Science

The purpose of this paper is to provide strategies for clinicians to manage difficult patient interactions. A comprehensive search of PubMed was conducted, identifying articles that identified the root cause of difficult patient interactions and assessed methods for successfully navigating these situations. The term “difficult patient” reflects the interaction of patient behavior, clinician perception, and systemic constraints rather than an inherent patient flaw. Effective management involves reframing difficult behavior as an expression of unmet needs and responding with empathy, active listening, clear boundaries, and collaborative decision-making. System-level strategies reduce patient distress and clinician burnout. Ultimately, the difficult patient represents strained …

Physician Assistants And The Medical Science Liaison Role: Expanding Career Pathways Beyond Clinical Practice, Michael Filsinger

Lynchburg Journal of Medical Science

ABSTRACT

The purpose of this article is to examine how physician assistants can transition into Medical Science Liaison roles within the pharmaceutical and biotechnology industries. Growing interest in nonclinical career pathways has prompted more physician assistants to explore opportunities in medical affairs, yet many remain uncertain about the qualifications, expectations, and academic preparation associated with these positions. A focused literature review was conducted to evaluate the competencies required for Medical Science Liaison roles, the barriers clinician applicants often encounter, and the strategies that may support successful transition into industry-based careers. Findings show that physician assistants possess relevant strengths such as …

Returning To Roots: A Self-Study Of Married Faculty Transitioning To Faculty Roles At Alma Maters, David Wolff, Melissa Wolff, Mark Diacopoulos

The Interactive Journal of Global Leadership and Learning

This self-study explores the transition of two faculty members returning to teach at their alma maters. Using visual methods, reflective journals, and peer dialogue, the researchers documented their experiences over six months. Triangulated data revealed eight themes, including: Identity Formation, Shifting Perspectives from Student to Faculty, Interpersonal Attunement, Navigating Changes, Memories Shape Perception, Occupational Stressors Impacting Transitions, Student Advocacy, and Personal Growth. The study highlights how personal and professional identities evolve during career transitions, and how reflective practices can deepen understanding of adaptation in higher education. These findings contribute to the literature on faculty development and offer insight into the …

Models Of Care In Higher Education: Comparing Integrated And Standalone Approaches To Student Mental Health, Tevia Q. Strand

The Interactive Journal of Global Leadership and Learning

This qualitative study examines how the organization of campus mental health services—integrated, co-located care versus standalone counseling centers—shapes college students’ awareness, access, stigma/privacy, and engagement. Semi-structured interviews with five Midwestern undergraduate women (n = 5) explored perceptions of visibility, ease of use, barriers, and improvement ideas. Transcripts were analyzed using reflexive thematic analysis. Themes included confusion about entry pathways, visibility-related stigma, and the salience of faculty/peer bridges to services. Students generally preferred integrated models, citing privacy through co-location, normalization, and easier warm handoffs; some noted that standalone centers can feel more specialized yet risk heightened visibility depending on location. Findings …

Redefining Rural School Leadership In The Post-Pandemic Era: Lessons From Covid-19, Brennan Kent

The Interactive Journal of Global Leadership and Learning

The COVID-19 pandemic fundamentally reshaped educational leadership, especially in rural school settings where leaders confronted unique resource constraints, geographic isolation, and heightened community interdependence. This conceptual study reexamines rural educational leadership in the post-pandemic era through a synthesis of findings from Author’s (2023) dissertation, The Rural Education Leadership Experience Amid the COVID-19 Pandemic, and current leadership theory. Drawing on the McREL Balanced Leadership Framework alongside adaptive and servant leadership models, the analysis identifies four interrelated dimensions that define post-pandemic rural leadership: communication as community cohesion, relationships as infrastructure, adaptive leadership as necessity, and well-being as a leadership priority. These …

Voices From The Other Side: Leadership Practices Teachers Value For Equity Systems Change, Heather L. Dunham, Heather Dunham

The Interactive Journal of Global Leadership and Learning

A growing body of scholarship has explored leadership for equity through frameworks such as social justice leadership (Theoharis, 2010), culturally responsive leadership (Khalifa et al., 2016), and equity audits (Skrla & Scheurich, 2004). Yet, these efforts often target isolated symptoms of inequity—achievement, discipline, or inclusion—rather than engaging in systemic reform that addresses both the ostensive and performative routines sustaining racialized practices. This study centers the Integrated Comprehensive Systems (ICS) for Equity framework (Capper & Frattura, 2017) to examine teachers’ perspectives on leadership practices that support organizational equity systems change.

Using a qualitative multi-case study design (Stake, 1995), two Midwestern schools …

Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan

The Interactive Journal of Global Leadership and Learning

This white paper explores trauma recovery through the lens of Paulo Freire’s Pedagogy of the Oppressed (1970/2018), framing healing as an act of critical consciousness and liberation rather than passive survival. Using the author’s lived experience of stalking, manipulation, and emotional abuse as a case study, it reimagines recovery not as a return to normalcy but as a dialectical process of reclaiming narrative agency, reconstructing identity, and transforming pain into purpose. Drawing upon Freirean concepts of conscientização (critical consciousness), dialogue, and praxis, the paper outlines a model for survivors to move from internalized oppression toward empowerment and social transformation.

Voices From The Hyflex Classroom: Understanding The Graduate Counseling Student Experience, Taryn Akgul, Jessica Brown, Aaron Suomala Folkerds

The Interactive Journal of Global Leadership and Learning

Counselor education and counseling master’s Programs face a changing landscape in higher education. This includes balancing the demand for a high-quality HyFlex program that prepares students for the counseling field. This qualitative exploratory study utilized a phenomenological approach to understand the counseling master's student experience in a hybrid program. The research questions focused on the students' experience attending the program either strictly on zoom, in person, or a combination of both and how that impacted them and their learning. The study consisted of eight participants who were alumni from one CACREP accredited counseling masters program. The findings included themes of …

Editor's Preface, Leo-Martin Angelo R. Ocampo

Loyola Papers

No abstract provided.

The Internally Displaced Persons In Fada N’Gourma Diocese, Burkina Faso: A Study On Human Dignity In The Light Of Catholic Social Teaching, Wendpouiré Améline Kabore

Loyola Papers

This study explores the experiences of the Internally Displaced Persons in the Diocese of Fada N’Gourma in Burkina Faso amid terrorism. It uses the See-Judge- Act method of Catholic Social Teaching to investigate the challenges to IDPs’ dignity. The observations reveal an IDP population victimized by discrimination and neglect within the host communities, emphasizing the moral imperative to uphold dignity. The research contributes to theological reflection on displacement and dignity while highlighting the Church’s unique faith-based humanitarian assistance, free from proselytism and political agendas despite the structural and practical limitations and difficulties.

From Dirty Work To Good Work: A Catholic Business Leader’S Perspective On Transforming The Social Construct Of Dirty Work To Humanizing Work, Andrea Claudia F. Zulueta-Lorenzana

Loyola Papers

In December 2024, the Philippine employment rate exceeded 95%, yet 57% of Filipinos still considered themselves poor. High employment conceals the prevalence of “bad jobs” marked by low wages, informality, and social stigma—what sociologist Everett Hughes termed dirty work—work society deems disgusting or degrading. This article examines dirty work through the lens of the Catholic business leader seeking an integrated life of faith and stewardship guided by Catholic Social Teaching (CST). It asks: How does dirty work evolve into dehumanization? Which CST principles respond to it? And how can these guide Filipino business leaders toward humanizing work? CST offers a …

Desire For The Good: A Philosophical Roadmap Through Spacetime, Bertrand Leong

Loyola Papers

No abstract provided.

Contributors, Contributors Contributors

Loyola Papers

No abstract provided.

Full Issue, Volume 7, Issue 2

Loyola Papers

No abstract provided.

Comparing Power Outputs Of A Jump Shrug With A Hex Bar Vs A Straight Bar, Joshua Neumann

Doctorate in Kinesiology

The purpose of this dissertation was to examine whether barbell selection influenced power outputs during loaded jump shrugs in collegiate athletes and to connect research findings to practical applications in strength and conditioning. Although Trap Bars are often assumed to provide mechanical advantages during explosive lifts, limited research has evaluated their impact during ballistic derivatives such as jump shrugs. This study addressed that gap by comparing the performance of Straight Bar and Trap Bar exercises across four standardized loads in male and female Division II athletes. A repeated-measures design was used to assess barbell velocity, concentric mean power, peak landing …

An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Energy consumption is increasing every day due to the proliferation of smart homes and smart household appliances, which deplete existing energy resources. Therefore, efficient energy management by accurately predicting energy consumption is critical. In this paper, a hybrid prediction model is proposed to forecast energy consumption in smart homes using weather data. The proposed system follows five steps: data acquisition, data preprocessing, feature selection, prediction, and hyperparameter optimization. In the data acquisition step, all attributes except the weather attributes are removed. The min-max algorithm is then applied to normalize the dataset to a specific scale, preventing the prediction model from …

Technology-Enabled Cognitive Behavioral Therapy For Insomnia (Cbt-I) In Older Adults With Mild Cognitive Impairment: Development And Feasibility Study, Hongtu Chen, Marta Pagán-Ortiz, Sara Romero Vincente, Emma Chapman, James Maxwell, Otis L. Owens, Sue E. Levkoff Scd, Msw, Sm

Faculty and Staff Publications

Background/Objectives: Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and early dementia, affecting up to 20% of older adults. Sleep disturbances, particularly insomnia, affect around 60% of individuals with MCI, contributing to declines in cognitive and physical function. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) is an evidence-based non-pharmacological treatment, few studies have adapted it for individuals with MCI. This pilot study developed and evaluated Slumber, a clinician-supported mobile CBT-I app tailored for older adults with MCI and insomnia. Methods: The study had three aims: (1) to develop the app for delivering CBT-I to individuals with …

Financial Ratios And Stock Volatility: Empirical Evidence From The Banking Sector, Rahma Tri Benita

Journal of Accounting Auditing and Business

Banking stock price volatility is closely related to company performance and fundamental indicators. This study analyzes the short-term and long-term relationships between financial ratios and stock price volatility in the banking sector. Based on the results of the long-term correlation, the Price to Earnings Ratio (P/E) and Dividend Yield (DY) variables are proven to be dominant factors influencing volatility because they are directly related to stock price movements. In the short-term correlation between state-owned banks, there is an inverse relationship between Price to Book and ROE, and Debt to Equity has a significant negative effect on Return on Assets and …

Multipath Exploitation For Radar Sensing In An Urban Environment Using The Music Algorithm For Jammer Mitigation, Daniel De Zutter

Theses

With the increased push for spectrum sharing techniques, the technological world surrounding radar has been constantly pushing to find new methodologies. From being able to integrate with a communication system to mitigating the effects of other users on a system, the research community is pushing forward. We look to tackle the problem of mitigating a jammer using a multipath MUltiple SIgnal Classification (MUSIC) based approach. We take multiple steps to implement this and generate a framework for future work. We first take a look at understanding the current state of the art research surrounding DFRC, multipath exploitation, MUSIC algorithms, RIS …

The Distribution Of Cadmium And Its Isotopes In The Subarctic Pacific, J. M. Malloy, H. R. Hunt, M. Sieber, S. Takano, H. Obata, T. M. Conway

Making Waves REU

• Cadmium (Cd) is a bioactive trace element that can act as a micronutrient, driving large scale chemical processes like photosynthesis and cellular respiration [1,2].
• The uptake of major nutrients is limited by dissolved iron (Fe) availability in high nutrient low chlorophyll (HNLC) surface regions like the subarctic Pacific [2,4].
• Upwelling of Cd-rich deepwater is a Cd source, in addition to riverine, atmospheric, and anthropogenic inputs [1].
• Dissolved cadmium isotopic compositions (δ114Cd) provide insight into the biogeochemical processes controlling Cd distributions throughout the water column, including biological uptake in surface waters, regeneration, and water mass mixing at depth.
• Here we present …

Real-World Data Investigating The Frequency Of Flash Glucose Monitoring And Glycaemic Metrics In Omani Diabetes Patients: A Preliminary Retrospective Cross-Sectional Study, Ammar Al-Mamari, Sumaia Al Gharabi, Merah Al Busaidy, Abdulla Al Futaisi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate real-world glycaemic outcomes associated with flash glucose monitoring (FGM) use in patients with diabetes at Sultan Qaboos University Hospital, Muscat, Oman. Methods: This retrospective cross-sectional study was conducted among diabetic patients using flash glucose monitoring between January 2022 and August 2023. Patients were grouped by scanning frequency, time-in-range (TIR) and estimated A1c (eA1c). Associations between scanning frequency and glycaemic metrics were analysed. Results: A total of 436 patients were included in this study. Patients with higher scanning frequency (≥12 scans/day, median = 17) achieved greater TIR (52.4% versus 34.8%), lower time-above-range (41.8% versus 57.0%), …

Effect Of Remineralization And Resin Infiltration On Microhardness, Mineral Content And Cervical Microleakage Of Restored Demineralized Enamel, Sara Adel Botros, Caroline Maged Massieh

Dentistry

No abstract provided.

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectivesThe chronic kidney disease (CKD) patients were at high risk for severe clinical complications during the COVID-19 pandemic. Our objectives were to evaluate comorbidity prevalence; predict mortality risks for CKD patients during the pandemic; assess how various health factors interact to influence mortality; and provide insights for targeted prevention strategies.MethodWe analysed data from 186,396 CKD patients in Mexico during the entire pandemic (Jan 2020- May 2023). Explainable artificial intelligence (XAI) methods with extreme gradient boosting (XGBoost) models and Shapley Additive Explanations (SHAP) were developed to predict mortality for CKD patients with model interpretations. Different metrics were used to comprehensively evaluate …

Grief, Memory, And Hope: Significance Of Ancestral Land In Psalm 137, “By The Rivers Of Babylon,” In Healing Intergenerational Migration Trauma, Shimbo Pastory William

Loyola Papers

Psalm 137 presents a paradigmatic expression of exile and lament, and the power of shared hope to return to the ancestral land. Memories trigger strong feelings and a firm resolve not to “forget” the ancestral home. This paper argues from a constructive perspective that in Psalm 137, the memory of ancestral land is not merely nostalgic or a source of grief, but it functions as a theological act that preserves communal identity and sustains hope for restoration and healing. Even today, we feel strongly about land, especially ancestral lands, because they are closely connected to our identity, cherished memories, grief, …

Sola Scriptura As Prima Scriptura: A Modern Evangelical Protestant Reflection On The Sufficiency Of Scripture, Jason Valeriano Hallig

Loyola Papers

This paper offers a critical evangelical response to Salvador G. Agualada Jr.’s analysis of the Protestant principle of sola Scripturaa, particularly his engagement with Roman Catholic critiques grounded in Yves Congar’s arguments concerning the temporal precedence of tradition and the alleged formal insufficiency of Scripture. While acknowledging the historical development of Protestant reflection on Scripture and tradition, this study argues that sola Scriptura is best understood not as the exclusion of tradition but as the affirmation of Scripture’s normative and final authority within the life of the church. Drawing on contemporary evangelical theology, the paper proposes that this principle …

Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Xiangjun Tian, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick

Faculty, Staff and Student Publications

Due to the paucity of validated cell surface osteosarcoma-specific targets, patients with this condition have long been excluded from the benefits of antibody-drug conjugate (ADC) therapy observed in patients with several solid and hematologic malignancies. Our comprehensive surfaceome profiling approach previously identified osteosarcoma-specific cell-surface antigens that are highly expressed in osteosarcomas but minimally expressed in normal tissues. As a result, one such antigen, CADM1, was selected for the generation of an ADC. We tested a CADM1-targeting ADC with a tesirine payload (SG3249) in vitro in osteosarcoma, rhabdomyosarcoma, and neuroblastoma patient-derived xenograft cell lines. In vivo, we tested six CADM1-expressing osteosarcoma …

Flipi24: A Modern Prognostic Model And Clinical Trial Enrichment Tool For Newly Diagnosed Follicular Lymphoma, Matthew J Maurer, Vit K Prochazka, Tarec Christoffer El-Galaly, Christopher R Flowers, Diego Villa, Elliot J Cahn, Melissa C Larson, Caroline E Dietrich, Lasse Hjort Jakobsen, Hervé Ghesquières, Robert Kridel, Maher K Gandhi, Chan Y Cheah, Eliza A Hawkes, John F Seymour, Ciara L Freeman, Michael R Clausen, Björn E Wahlin, Jonathan W Friedberg, Carla Casulo, Thomas M Habermann, Yucai Wang, Loretta J Nastoupil, Peter De Nully Brown, David Belada, Andrea Janíková, Heidi Mocikova, Tomáš Fürst, Pierre Feugier, Hervé Tilly, Corinne Haioun, Andrew J Davies, Guillaume Cartron, Richard Burack, Dai Chihara, Peter Martin, Jonathon B Cohen, Izidore S Lossos, Brad S Kahl, Laurie H Sehn, Karin E Smedby, Gilles Salles, Marek Trneny, Brian K Link, Franck Morschhauser, James R Cerhan

Faculty, Staff and Student Publications

Purpose: Although most patients with follicular lymphoma (FL) can expect an indolent course, progressive lymphoma remains the primary cause of death during the first decade after diagnosis. Progression of disease within 24 months (POD24) of starting first-line (1L) immunochemotherapy defines a high-risk population with poor survival, but better risk stratification at diagnosis is needed.

Methods: The FLIPI24 model was developed and internally validated to predict 24-month event rates using individual data from 4,485 patients treated with 1L immunochemotherapy from 10 observational cohorts of FL. Overall and cause-specific survival was further evaluated in FLIPI24 risk groups. External validation in the 1L …

Fragmented Foundations: Interpreter Educator Resources And Uneven Student Preparation, Kierstin S. Muroski

Journal of Interpretation

The readiness-to-work gap among graduates of signed language interpreting programs has been widely acknowledged for decades. Efforts to address the gap have primarily focused on training methods and student performance. This paper shifts the focus to interpreter educators, examining whether the inconsistencies in their awareness and use of discipline-related books may contribute to the disparate educational outcomes of students entering the workforce. Drawing on survey data from 75 interpreter educators in the United States, this study explores demographic patterns of their book awareness and usage in teaching. Results indicate that awareness and utilization of discipline-related books to support teaching are …

Defending And Challenging American Empire: The 1927-28 University Of Oregon Forensics Program World Debate Tour And The November 25, 1927, Manila "Debate Of The Century", Trond Jacobsen, David Frank

Studies in Debate and Oratory

From October 1927 through April 1928, three Oregon debaters traveled more than 25,000 miles to seventeen countries on four continents, participating in thirty-two debates and seventy-five public speaking engagements as part of the first-ever Debate World Tour. This tour was audacious, but indicative of a remarkable history of debate at Oregon. Drawing on archival materials held by the Special Collections and University Archive at the University of Oregon and other primary and contemporary materials, we document that world tour and feature a November 25, 1927, debate on Filipino independence at the Manila Opera House and the tour of America by …