Digital Commons Network^™

The Historiography Of The National Movement In Tunisia Between The Official, The Militant, And The Academic, Aamira Aaliya Seghir

Basamat

No abstract provided.

Geography Between Social And Human Sciences: New Developments Of Globalization, Mostapha Nachoui

Basamat

No abstract provided.

Geomorphology From Geological Time To Lived Time: Application To The Doukkala-Abda Region., Mohamed Mohyieddine

Basamat

No abstract provided.

Towards The Professionalization Of Press Relations Between The Public Administration And Journalists In Morocco, Rachida Bouzidi

Basamat

No abstract provided.

The Sacred King And The Profane King: The Case Of Louis Xiv, Anouar Marzouki

Basamat

No abstract provided.

Time And Pause In Spontaneous Speech, Lahcen Ouasmi

Basamat

No abstract provided.

The Metaphoric Structuring Of Time In Moroccan Arabic, Khalid Berrada

Basamat

No abstract provided.

Imagination And Time Against The Tearing Of The Social Fabric, Abdelbaki Belfakih

Basamat

No abstract provided.

A Case Report Of Shwachman-Diamond Syndrome And Literature Review, Xinfeng Gao, Jizhong Wang

Journal of Pediatric Genetics

Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive genetic disorder, with approximately 90% of cases caused by pathogenic variants in the SBDS gene. This report describes a case of SDS diagnosed during the management of acute appendicitis. The patient, a male aged two years and 11 months, was admitted for emergency surgery for acute appendicitis. Subsequent evaluation revealed pancreatic exocrine dysfunction, pancreatic steatosis, abnormal liver function, and a history of recurrent diarrhea and neutropenia. Next-generation sequencing identified compound heterozygous SBDS variants: NM_016038.2:c.183_184TA>CT (p.Lys62*) and NM_016038.2:c.258+2T>C. This case highlights the importance of considering SDS in children presenting with recurrent …

Fanconi-Bickel Syndrome With Variable Phenotypes: A Case Series Highlighting A Successful Pregnancy Outcome From A Tertiary Care Center In North India, Pragya Kafley, Varunvenkat M. Srinivasan, Chaitra Ravi, Sangeeta Das, Pooja Motwani, Kausik Mandal

Journal of Pediatric Genetics

Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive disorder caused by biallelic mutations in the SLC2A2 gene, characterized by proximal renal tubular dysfunction, hepatomegaly, and growth failure. We report five patients from three unrelated families in North India, including a sibling trio with significant intrafamilial variability and one of the few documented successful pregnancies in an affected female. Genetic testing identified a recurrent nonsense variant c.1093C>T (p.Arg365Ter) in two families and a missense variant c.1330T>C (p.Trp444Arg) in the third. The phenotypic spectrum ranged from mild growth delay to severe skeletal involvement and poor therapeutic response. Our report underscores …

A Study Of Diagnostic Experience And Impacts Of Rare Disease Diagnosis In Children And Their Families: Insights From India, Nidhi Vijay, Ashok Gupta, Priyanshu Mathur, Megha Sharma

Journal of Pediatric Genetics

Objective: Many rare diseases are usually misdiagnosed or diagnosed late. Delays in diagnosis have led to delayed treatment, resulting in poor outcomes. This study aims to shed light on the Indian scenario and help formulate schemes for early diagnosis, management of rare diseases and to uncover the unmet needs of the families of children with rare diseases. Methods: The target population were families with a child (17 years or younger) with any rare disease coming to SPINPH, Jaipur. The first author met face-to-face with the parents and they were made to answer a questionnaire. The questionnaires were checked for completeness …

Tethered Spinal Cord And Urinary Tract Complications In Trisomy 18, Michael A. Phillipi, Ladawna Gievers, Jesse L. Winer, Casey Seideman, Amanda J.H. Kim

Journal of Pediatric Genetics

Background: Trisomy 18 is an aneuploidy that has historically been associated with early mortality However, recently parents of children with complex conditions are more often pursuing life-prolonging medical interventions. The increasing use of neonatal intensive care has led to longer lifespans in infants affected by trisomy 18, allowing for later complications to emerge. While many comorbidities have been reported in the literature, tethered cord has rarely been reported in this population. This study examines the potential relationship between trisomy 18, tethered spinal cord, and related urinary tract complications. Methods: A retrospective chart review of subjects admitted to a single quaternary …

Lesch-Nyhan Disease A Treatable Mimicker Of Dyskinetic Cerebral Palsy In Boys: Insights From An Indian Series Of Six Cases With Report Of Four Novel Variants, Vykuntaraju K. Gowda, Spoorthy Nelaji Karunakar, Varunvenkat M. Srinivasan, Viveka-Santhosh Reddy

Journal of Pediatric Genetics

Background: HPRT1-related disorders are X-linked metabolic disorders of the purine pathway caused due to mutations in the hypoxanthine-guanine phosphoribosyl transferase (HPRT1) gene and present with features of dyskinetic cerebral palsy, self-mutilation/behavioral abnormality, and hyperuricemia in variable severity. Objective: Describe the clinical characteristics and treatment outcome of a series of 6 children with Lesch-Nyhan disease. Methods: Retrospective chart review from September 2022 to July 2024 of six molecularly confirmed cases of Lesch-Nyhan disease from India. Results: A total of 6 boys are described here. The mean age of onset was since birth, the age of diagnosis was 2 years 7 months, …

Taming Psoriatic Inflammation: Targeting The Inos–Oxidative Stress–Necroptosis Axis For Precision Therapy, Tolulope Omotope Omolekan, Tithi Roy, Jean Christopher Chamcheu

Faculty Publications

Necroptosis is increasingly recognized as a central driver of psoriatic inflammation, promoting keratinocyte death and sustaining immune activation. Recent evidence shows that inducible nitric oxide synthase (iNOS) deficiency and exogenous nitric oxide (NO) supplementation ameliorate psoriasis-like dermatitis in mice by reducing oxidative stress and constraining necroptotic signaling. These findings identify iNOS-derived NO as both a mediator of reduction–oxidation (redox) imbalance and a key regulator of necroptosis, thereby advancing mechanistic insight into psoriatic pathogenesis. Importantly, they highlight the iNOS–oxidative stress–necroptosis axis as a translationally actionable therapeutic target. Modulating necroptotic cell death through NO-based interventions may restore epidermal homeostasis and improve clinical …

The Expansion Of Exposure Notification Software To Enhance Disease Surveillance And Ring Vaccination, Julia Felton

URGENT Matters

No abstract provided.

Global Spatiotemporal Multi-Criteria Analysis Of Coastal Risk: Current And Future Hot Spots And Clusters, Marco Bidoia, Carlo Giupponi

Fondazione Eni Enrico Mattei Working Papers

Coastal zones are among the environments most threatened by climate change. Although various efforts for global mapping and classification of coastal social and ecological systems have been undertaken, the ability to analyse and describe the spatial heterogeneity and multidimensionality of these phenomena remains limited. In the current study, we developed a methodological framework for assessing risk from extreme sea levels and examined its application at the global level. A multi-criteria analysis method was applied to the current scenario and to two future combinations of shared socioeconomic (SSP2 and 5) and representative concentration pathways (RCP4.5 and 8.5), accounting for risk attitudes. …

Clinical Outcomes Of Patients Hospitalized For Conventional Pacemaker Implantation With Protein-Energy Malnutrition, Phuuwadith Wattanachayakul, Pojsakorn Danpanichkul, Chalothorn Wannaphut, Hamza Tahir, John Malin, Thanathip Suenghataiphorn, Kanokphong Suparan, Aman Amanullah

Einstein Health Papers

INTRODUCTION: The impact of protein-energy malnutrition (PEM) on patients hospitalized for conventional pacemaker implantation remains poorly understood.

METHODS: We utilized the 2020 U.S. National Inpatient Sample (NIS) database to evaluate the impact of PEM on the in-hospital outcomes of patients who underwent conventional pacemaker implantation. Patients aged 18 and older were identified by ICD-10 CM and PCS codes. Multivariable survey logistic and linear regression analyses were employed to examine in-hospital outcomes, including in-patient mortality, system-based outcomes, and post-procedural complications.

RESULTS: A total of 108 020 patients were identified with 4315 (3.99%) diagnosed with PEM. The mean age of the cohort …

The Perception Of Fentanyl’S Harm, Rachel Antenucci

ETDs from 2020-2029

While drug overdose deaths have generally decreased in the past year, close to 60,000 overdoses involving opioids occurred in 2024. The opioid crisis has lasted over two decades and is now in the fourth wave. The fourth wave has been characterized by overdoses resulting from fentanyl adulteration in the drug supply and polysubstance overdoses involving fentanyl. The purpose of the current study is to compare the perceived harm of fentanyl to other drugs of abuse and identify differences in the perceived harm of fentanyl between groups of people who use substances. An online survey was conducted across 15 states in …

Strengthening The Use Of Sexual And Reproductive Health And Rights Evidence In Refugee And Humanitarian Settings, Baobab Research Programme Consortium

Humanitarian Task Force

This guide offers practical, experience-based direction for strengthening the uptake of sexual and reproductive health and rights (SRHR) evidence in refugee and humanitarian settings. Drawing on five years of Baobab’s work in Uganda and Ethiopia, it outlines principles for effective research uptake, including embedded partnerships, rigorous locally owned methods, stakeholder engagement, capacity development, adaptive communication, and continuous learning. The guide illustrates how these approaches enabled pioneering evidence generation—such as the first Humanitarian Violence Against Children Survey (VACS)—and informed service innovations, national policy reforms, and cross-country learning. It provides a replicable framework for translating SRHR research into action and system level …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Effects Of Hydro- And Nano-Priming Treatments On Seed Germination And Metabolism In Sugar Beet (Beta Vulgaris L.), Sarah Jorjani, Ömer Can Ünüvar, Songül Gürel, Ekrem Gürel

Turkish Journal of Botany

This study examined the effects of hydropriming and nanopriming on the germination and physiological parameters of sugar beet seeds. Seeds were treated with distilled water as a traditional method and with TiO2 nanoparticle solutions at concentrations of 5, 10, and 15 ppm as an advanced method. Seeds were soaked for 3, 6, and 9 h, followed by postpriming maintenance for 10 and 45 days. T he results indicated no statistically significant differences in germination rates between the control and primed groups. Both priming methods markedly increased alpha-amylase activity and chlorophyll content, indicating improved metabolic and photosynthetic potential. Notably, nanopriming for …

Modeling Global Ecological Niche Shifts Of Osyris Spp. Under Climate Change Scenarios: Conservation Priorities For A Threatened Genus, Meng Ting-Yao, Han Shun-Long, He Xiang-Tian, Wu Ya-Ni, Fengjuan Mou

Turkish Journal of Botany

The genus Osyris L. comprises ecologically and economically important evergreen shrubs or small trees, with particular African species currently threatened by unsustainable exploitation. This study projected potential ecological niche shifts for Osyris under four Shared Socioeconomic Pathways (SSPs) using digitized herbarium specimen localities and 20 environmental variables. The genus currently occupies a broad range between 41.32°N–34.85°S latitude and 9.27°W–109.03°E longitude, at elevations from 0 to 3900 m. High-suitability areas cluster primarily in the European-Mediterranean region, eastern/southern Africa, western South America, and Southeast Asia. Projections indicate a significant decline in high-suitability area under all SSP scenarios (SSP126, SSP245, SSP370, SSP585) compared …

A Novel Strategy Of Mycorrhizal Fungi Usage To Enhance Crop Resilience In Saline Environments: Biopriming With Serendipita Indica, Tuğba Özteki̇n, Meli̇sa Ayişiği, Lale Yildiz Aktaş

Turkish Journal of Botany

Soil salinization is a critical global challenge, threatening agricultural productivity by imposing osmotic stress, ionic toxicity, and oxidative imbalance in plants. This study investigated the potential of Serendipita indica biopriming to enhance salt stress tolerance in maize (Zea mays L. cv. Simon) seedlings through comprehensive physiological and biochemical analyses under controlled conditions. Maize seeds were bioprimed with different concentrations of mycorrhizal fungi S. indica spores and exposed to varying NaCl concentrations (0, 50, 100, and 200 mM). Nonprimed maize seedlings had a gradual reduction in seed vigor index, reaching about 93.56% in 200 mM NaCl treatment. Under nonsaline conditions, S. …

Taxonomic Significance Of Stem And Leaf Anatomy And Pollen And Seed Micromorphological Characters In The Papaver (Poppy) Sect. Rhoeadium From Türkiye, Esengül Özkaymakoğlu, Osman Tugay, Yavuz Bülent Köse, Deni̇z Ulukuş, Bayram Atasagun, Meti̇n Armağan, Ferhat Celep

Turkish Journal of Botany

The poppy (Papaver) has beautiful flowers that attract the attention of not only taxonomists but also the public. However, it also presents several taxonomic problems. This study examines 13 taxa of Papaver sect. Rhoeadium, including the following species native to Türkiye: P. purpureomarginatum, P. dubium subsp. dubium, P. dubium subsp. laevigatum, P. arachnoideum, P. arenarium, P. commutatum subsp. euxinum, P. guerlekense, P. rhopalothece, P. stylatum, P. clavatum, P. syriacum, P. rhoeas, and P. postii. Plant specimens were collected from natural populations, and anatomical investigations were carried out on stem and leaf cross-sections. Pollen and seed features were examined using both …

Complete Genome Characterization Of A New Alphapartitivirus Identified In The Ectomycorrhizal Fungus Lactarius Mediterraneensis, Aigul Kali̇yeva, Ergi̇n Şahi̇n, Gülce Edi̇ş, Ilgaz Akata

Turkish Journal of Botany

Viruses that naturally infect fungi capable of forming mycorrhizal symbioses remain poorly studied. In the present study, a new partitivirus associated with the basidiomycete mycorrhizal fungus Lactarius mediterraneensis was identified and characterized, and it was designated as Lactarius mediterraneensis partitivirus 1 (LmPV1). The complete genome of LmPV1 was determined through high throughput sequencing of double-stranded RNA (dsRNA) extracts and confirmed by Sanger sequencing of RLM-RACE PCR amplicons. T he genome comprises two dsRNA segments, 1899 bp and 1957 bp, each containing a single open reading frame (ORF) a putative RNA-dependent RNA polymerase (RdRp) and a capsid protein (CP). Comparative analysis …

Changing Patterns Of Psychotropics Use Among Older Adults With Intellectual Disability Over A Decade, With A Focus On Designated Mental Health Conditions, Rohit Shankar

Peninsula Medical School

ABSTRACTBackground: Psychotropics (sometimes off-label), mental health diagnoses and behaviours of concern are common in olderadults with intellectual disability. Guidelines recommend non-pharmacological interventions and regular medication review.This study examined changes in psychotropics among older adults (≥40) with intellectual disability.Methods: Longitudinal data were obtained from the Intellectual Disability Supplement to the Irish Longitudinal Study onAgeing (IDS-TILDA) at two timepoints [Wave 1(2009/10); Wave 4(2019/20)]. Post hoc analysis, Chi-squared tests and univariatebinary logistic regression were conducted.Results: Overall, psychotropics decreased (59.2% to 56.5%). Significant decreases in antipsychotics (43.1%–40.1%) and sedatives/hypnotics (13.6%–8.1%) and significant increase in antidepressants (26.2%–31.8%) were found. Nearly half of antidepressant usersreported depression …

Strategies For Retaining Employees In The Global Healthcare Industry, Tanisha L. Smith

Walden Dissertations and Doctoral Studies

High healthcare employee turnover rates pose a significant threat to organizational productivity, workforce stability, and patient outcomes. Healthcare leaders are concerned with high employee turnover because it contributes to rising operational costs, employee burnout, and a decline in the quality of patient care. Grounded in Herzberg’s two-factor theory of motivation, this qualitative, pragmatic inquiry identified and explored effective strategies that healthcare leaders use to retain employees to maintain organizational productivity and enhance patient outcomes. Data were collected from nine healthcare leaders in the United States using semistructured interviews and publicly available documents. Through thematic analysis with triangulation and member checking …

Enhancing Rn Confidence In Early Recognition And Treatment Of Sepsis, Tiffany Lee Gossai

Walden Dissertations and Doctoral Studies

Background: Sepsis is a leading cause of mortality in U.S. hospitals, with delays in recognition and treatment significantly contributing to poor patient outcomes. Nurses are essential to early identification and timely intervention; however, gaps in confidence and preparedness persist, particularly among newly hired staff. Traditional educational approaches may be insufficient to support rapid clinical recognition and evidence-based management. Purpose: This staff education project evaluated whether participation in a virtual sepsis escape room during general nursing orientation improved newly hired nurses’ confidence in early identification and treatment of sepsis. Methods: A virtual escape room was integrated into an existing general nursing …

Better It Disaster Recovery And Procedures To Improve Response After Computer Crime, Allan Eduardo Arroyo-Melendez

Walden Dissertations and Doctoral Studies

A lack of an effective disaster recovery plan (DRP) can negatively impact business outcomes following a cyberattack. Information technology (IT) managers are concerned that the lack of DRP may increase the risk of ransomware, fines, and public distrust. Grounded in the unified theory of acceptance and use of technology, the purpose of this qualitative pragmatic inquiry study is to explore strategies that some IT managers use to implement a DRP. The participants are four IT managers in the southeast United States. Data were collected through semistructured interviews and a review of publicly available documents. Through thematic analysis, three themes were …

Clinical Practice Guidelines For Suicide Risk Assessment, Jelitta Cleatus

Walden Dissertations and Doctoral Studies

In this doctoral project, I developed a clinical practice guideline (CPG) to address the lack of a standardized suicide risk assessment protocol at a Texas mental health clinic. At project initiation, suicide risk assessment at the facility was inconsistent due to the absence of a CPG. The guideline incorporated the Columbia-Suicide Severity Rating Scale (C-SSRS), a validated instrument that improved early detection of suicidal ideation and behaviors, which were often under recognized in older adults. This inconsistency led to the following clinical question, Does the evidence support the development of a CPG for assessing suicide risk among high-risk patients using …