Digital Commons Network^™

Clinical Features Of Infantile Epileptic Spasms Syndrome: A Systematic Review, Xiao Meng, Danielle S Takacs, Yashaswini Kelagere, Zihan Zhang, Sanjanaa Seshadri, Jiyeon Cha, Ming Li, Lei-Shih Chen

Faculty, Staff and Students Publications

Introduction

Infantile Epileptic Spasms Syndrome (IESS) is a severe epilepsy in children between one month and two years of age. Urgent referral of possible IESS cases from pediatricians and family physicians who care for children to neurologists for diagnosis and treatment has been shown to significantly improve patient health outcomes. Yet, a comprehensive list of IESS clinical features is lacking. We conducted a systematic review of studies to report IESS clinical features.

Methods

Articles from the MEDLINE Complete and Embase databases were searched from the earliest years of databases availability (1979) to July 31, 2024. We followed the Preferred Reporting …

Intouch Week Of February 2, 2026, New York Medical College

InTouch

• Campus Illumination and Panel Discussion Honors Holocaust Remembrance Day
• Where Experience Becomes Evidence: Advancing Transplant Education at NYMC
• D.P.T. Student Experience
• Love at NYMC

Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne

Faculty Publications

Conjugated thiophene-based diboronate esters, 1–4, were synthesized to investigate how substituents on catechol alter the Lewis acidity and accessibility to boron, and influence binding interactions with low molecular weight Lewis basic amines. Crystallographic analysis indicated that both boron centres bind analyte and that Lewis base coordination induces deplanarization of the conjugated system. Spectroscopic studies demonstrate that amine binding disrupts conjugation, producing distinct and reproducible optical responses that depend on analyte basicity and structure, with association constants in organic solvent ranging from 10³ to 10⁶ M⁻¹. Quantitative binding analyses indicate strong negative cooperativity between the two boron …

Contributor Bios, The North Meridian Review Editorial Staff

The North Meridian Review

No abstract provided.

Full Text, The North Meridian Review Editorial Staff

The North Meridian Review

No abstract provided.

Jackson-Pratt Drain-Related Challenges And A Potential Explanation For Associated Surgical Site Pain Variability Following Breast Mastectomy And Reconstruction, Spencer Haber, Bs, Krishna Koka, Bs, Elizabeth Simon, Bs, Devin Williams, Bs, Andrew Newman, Md

Alpha Omega Alpha Research Symposium Posters

Background: The Jackson-Pratt (JP) drain is a closed suction drain used in surgeries throughout the body. This prevents seroma formation through continual negative pressure drainage while resisting collapse and obstruction. JP drains are mainstays in breast reconstruction and mastectomy.

Methods: Through a literature review using keywords such as “Surgical Site Infection” (SSI), “Quality of Life” (QOL), and “Surgical Site Pain” (SSP), we summarized JP drain-related complications in breast reconstruction and mastectomy. Although the drain effectively reduces seroma formation, there has been a lack of innovation in addressing these issues. There is no standardized approach to JP drain post-operative care or …

Daily Coping Strategies, Unmet Needs And Daily Health Outcomes Among Family Caregivers Of Persons Living With Alzheimer's Disease And Related Dementias, Henrietta Armah Bennett

ETDs from 2020-2029

Providing care for an individual with Alzheimer’s Disease and Related Dementias (ADRD) is considered the most stressful type of family caregiving that impacts caregivers’ health. More than one in five ADRD family caregivers report their overall health as poor to fair. These adverse health outcomes are often exacerbated when caregivers’ emotional, informational, and practical needs remain unmet throughout the caregiving trajectory. Numerous studies have shown that the ways in which caregivers cope to caregiving-related stressors significantly shape their health outcomes. Despite this evidence, a clear and consistent understanding of caregivers’ own appraisals of their unmet needs, coping strategies and mental …

Pacific Rxtracts - February 2026, Pacific Rxtracts

Pacific RxTracts

Articles:

• Reducing Proteinuria – FDA Accelerates Approval of Sibeprenlimab
• FDA Approves Oral Semaglutide as First GLP-1 Pill for Weight Loss
• New First-Line Digital Treatment for Generalized Anxiety Disorder
• Ammoxetine: A Potential New Antidepressant For Major Depressive
• Extended-Release Buprenorphine Dosing in Individuals With High-Risk Opioid Use
• Managing Acute Agitation Without Injections: Oral Medications in the ED
• Prescription Stimulant Continuation in Pregnancy and Birth Outcomes
• Zoliflodacin - A New Treatment For Gonorrhea
• Intranasal Dexmedetomidine for Postoperative Sleep Quality After Gynecologic Laparoscopy
• FDA Approves Depemokimab, the First Twice-Yearly Biologic for Severe Eosinophilic Asthma Cancer Care
• Engineering Allogeneic CD7-Targeted CAR-T Cells Through Targeted Base …

Osimertinib Activates A Tgf-Β2-Dependent Secretory Program That Drives Lung Adenocarcinoma Progression, Madhurima Ghosh, Chao Wu, Abhishek Kumar, Monique Nilsson, John V. Heymach, Weina Zhao, Jiang Yu, Xin Liu, Na Ding, Shike Wang, Guan Yu Xiao, Angelo Chen, Kate Grimley, William K. Russell, Chad J. Creighton, Xiaochao Tan, Jonathan M. Kurie

Markey Cancer Center Faculty Publications

EGFR-mutant lung adenocarcinomas (LUADs) that are vulnerable to the EGFR antagonist osimertinib (Osi) eventually relapse, owing in part to the emergence of drug-tolerant persister (DTP) cells that arise through epigenetic mechanisms. Intratumoral DTP cells can herald a worse clinical outcome, but the way in which DTP cells influence LUAD progression remains unclear. Osi-resistant (OR) cells exhibit typical DTP cell features, including a propensity to undergo senescence and epithelial-mesenchymal transition (EMT), which can activate heightened secretory states. Therefore, we postulated that OR cells influence LUAD progression through paracrine mechanisms. To test this hypothesis, we utilized congenic pairs of EGFR-mutant LUAD cell …

Green Rules, Fragmented Fields: Member-State Approaches To Sustainability In Eu Competition Law, Niccolò Galli, Armando Santoni

Yearbook of Antitrust and Regulatory Studies

This article provides a comparative, normative-evaluative examination of how sustainability is being incorporated into European competition law. Combining doctrinal legal analysis with economic reasoning, it clarifies competing definitions of sustainability, maps the contest between the consumer-welfare paradigm and sustainability proponents, and evaluates the legal and institutional implications of the Commission’s 2023 Horizontal Cooperation Guidelines. Drawing on national initiatives across Member States plus the UK, the study highlights contrasting instruments, from Austria’s statutory environmental exemption to the Dutch soft-law safe harbour and Greece’s experimental sustainability sandbox, and shows how these divergent approaches produce fragmentation and legal uncertainty for cross-border cooperative initiatives. …

Law School News: Roger Williams University Marks Fred Korematsu Day With Reflection On Rights And Responsibility 02-02-2026, Kelly Brinza, Roger Williams University School Of Law

Life of the Law School (1993- )

No abstract provided.

Which Law School Is Right For Me? Admissions Q&A With Dean Estrada, New York Law School

NYLS Community News

No abstract provided.

Cd8+ T Cells In The Tumor Microenvironment Modulate The Response To Endocrine Therapy In Breast Cancer, Fabiana Napolitano, Yunguan Wang, Dhivya R Sudhan, Paula I Gonzalez-Ericsson, Luigi Formisano, Nisha Unni, Shahbano Shakeel, James Z Zhu, Khushi Ahuja, Lei Guo, María Rosario Chica-Parrado, Yuki Matsunaga, Pamela Luna, Chang-Ching A Lin, Yasuaki Uemoto, Kyung-Min Lee, Hongli Ma, Nathaniel J Evans, Alberto Servetto, Saurabh Mendiratta, Spencer D Barnes, Roberto Bianco, Yisheng V Fang, Lin Xu, Jeon Lee, Tao Wang, Justin M Balko, Gordon B Mills, Marilyne Labrie, Ariella B Hanker, Carlos L Arteaga

Faculty, Staff and Student Publications

The role of the tumor immune microenvironment (TIME) in modulating responses to antiestrogen therapy in hormone receptor-positive (HR+) breast cancers remains unclear. We analyzed pre- and on-treatment biopsies from patients with HR+ breast cancer treated with letrozole to induce estrogen deprivation (ED). Stromal tumor-infiltrating lymphocytes, assessed by H&E staining, and immune-related gene sets, including IFN-γ signaling genes, measured by RNA-Seq, were increased in ED-resistant tumors. Cyclic immunofluorescence and spatial transcriptomics revealed an abundance of CD8+ T cells and enhanced antigen processing and immune gene signatures in ED-resistant tumors. In this group, the expression of CXCL9, CXCL10, and CXCL11 - chemokine …

Hopelessness: Nothing Left But Silence Forging Silent Peacemakers Who Endure, Noah Novotny

Father Jack McGrath, S.M., Research Award Presentations

Noah Novotny is a recipient of the 2026 Father Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions.

The Chronic Apical Abscess: A Case Report On A Diagnostic Dilemma, Jonathan Hope, Guy Lambourn, Ewen Mccoll, Casper Jonker

Peninsula Dental School

A chronic apical abscess is an endodontic condition commonly characterised by the presence of a notable sinus tract through which pus periodically discharges. In general, these cases can be considered “straight forward” to diagnose but on some occasions, diagnosis can be challenging. Any misdiagnosis can compromise the treatment approach for the patient and lead to adverse outcomes such as unnecessary biopsies or referrals. Therefore, clinicians should follow a meticulous treatment approach consisting of appropriate diagnostic measures to establish the correct diagnosis and treatment pathway.

Temporal Linkages Of Explosive Activity Of Kolumbo And Santorini Volcanoes (Greece), Abigail Metcalfe, Katharina Pank, Steffen Kutterolf, Jonas Preine, Paraskevi Nomikou, Christian Hübscher, Thomas A. Ronge, Sarah Beethe, A Bernard, Carole Berthod, Hehe Chen, Shun Chiyonobu, Acacia Clark, Susan Debari, Tatiana Fernandez-Perez, Ralf Gertisser, Christopher Jones, Raymond Johnston, Kumar Batuk Joshi, Jens Karstens, Günther Kletetschka, Olga Koukousioura, Hao Yang Lee, Xiaohui Li, Michael Manga, Molly Mccanta, Iona Mcintosh, Tony Morris, Dimitrios Papanikolaou, Ally Peccia

School of Geography, Earth and Environmental Sciences

The histories of submarine explosive volcanoes are commonly poorly known due to inaccessibility of their eruptive archives. This raises uncertainties in the eruption frequencies of these highly hazardous systems, and in their interactions with neighboring volcanoes. The submarine Kolumbo Volcanic Chain (KVC) northeast of Santorini is made up of the polygenetic Kolumbo Volcano and a linear zone of more than 20 smaller volcanic cones and is one of the most active eruptive centers on the South Aegean Volcanic Arc. However, despite the destructive eruption of Kolumbo in 1650 CE, and unrest in 2024–2025, the eruptive history of the KVC is …

Search For Low-Mass Electron-Recoil Dark Matter Using A Single-Charge Sensitive Supercdms-Hvev Detector, M. F. Albakry, I. Alkhatib, D. Alonso-González, J. Anczarski, T. Aralis, T. Aramaki, I. Ataeelangroudy, C. Bathurst, R. Bhattacharyya, A. J. Biffl, P. L. Brink, M. Buchanan, R. Bunker, B. Cabrera, R. Calkins, R. A. Cameron, C. Cartaro, D. G. Cerdeño, Y. Y. Chang, M. Chaudhuri, J. H. Chen, R. Chen, N. Chott, J. Cooley, H. Coombes, P. Cushman, R. Cyna, S. Das

All Works

We present constraints on low-mass dark matter electron scattering and absorption interactions using a SuperCDMS high-voltage eV-resolution (HVeV) detector. Data were taken underground in the NEXUS facility located at Fermilab with an overburden of 225 meters of water equivalent. The experiment benefits from the minimizing of luminescence from the printed circuit boards in the detector holder used in all previous HVeV studies. A blind analysis of 6.1 g·days of exposure produces exclusion limits for dark matter-electron scattering cross sections for masses as low as 1 MeV/c², as well as on the photon-dark photon mixing parameter and the coupling …

Ndls Communicator: Week Of 02.02.26, Notre Dame Law School

NDLS Communicator

The Latest News

• 2026 Galilee Immersion Program: Exposing First-Year Law Students to the Impact of Public Interest Law
• Professor Jeffrey Pojanowski Named Inaugural Sydney Public Law Visiting Fellow

Student News

• The Office of the United Nations High Commissioner for Human Rights (OHCHR)’s Knowledge Hub for Economic, Social and Cultural Rights has published a new issue brief co-produced with the Notre Dame Global Human Rights Clinic. Student researchers and drafters from the Clinic worked closely with Professor Diane Desierto and research associate Faisal Yamil Meneses in contributing to the brief.

Faculty Briefs

• A.J. Bellia
• Michael Addo
• Fr. John Paul Kiimes
• Nicole …

Exploring Enacted Active Learning Practices In Postsecondary Chemistry Lecture And Laboratory Courses, Kendall M. Zammit

USF Tampa Graduate Theses and Dissertations

The work in this thesis begins to explore the enacted active learning practices in postsecondary chemistry lecture and laboratory courses. Chapter 1 explores the level of inquiry in postsecondary laboratories. Chapter 2 explores instructional and assessment practices at two-year institutions.

Chemistry postsecondary laboratories offer a unique opportunity to engage students in inquiry-based instruction. Inquiry-based instruction was categorized by the asking faculty members at four-institutions about six characteristics of laboratory design: choosing a problem, background research, designing procedures, analyzing data, communicating results, and interpreting results. As students have the freedom to make decisions on more characteristics of inquiry learning, the closer …

Mom Is Developing Too: Preliminary Evidence For The Reciprocal Effects Of Infant Sensory Reactivity And Maternal Behavior, Emily C. Sweiss, Vincent Berardi, Elysia Poggi Davis, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Caregiver sensitivity to infant cues is well-established as a predictor of child development. Infants also actively influence their social environment, especially their caregivers, even from their earliest days. Sensory reactivity, characterized as hypo- (under) and hyper- (over) responding to environmental stimuli, is one domain of development that is likely to influence caregiver-infant interaction, due to its role in regulating emotions and responses to both physical and social stimuli. Although sensory reactivity could be an important target for improving caregiver-child interaction, the longitudinal, reciprocal relations between infant sensory reactivity and caregiver behaviors are currently unknown. In the present proof-of-concept study, we …

A Robust Framework For Solving Pdes: Biorthogonal Spline Wavelet Methods, Mutaz Mohammad, Alexander Trounev

All Works

This paper presents a novel numerical approach for solving the partial differential equations (PDEs), focusing on the Diffusion equation. The method combines a collocation approach with wavelet techniques to achieve high accuracy in approximating solutions. A detailed framework for the proposed method, explaining the discretization process at multiple collocation points and the formulation of the resulting system of linear equations is provided. An implementation is conducted to demonstrate the method's effectiveness in capturing the complex behaviors typical of the model studied. Comparisons with analytical solutions underscore the robustness and precision of the technique, paving the way for its application in …

A Solution To The Tension Of Burning On Neutron Stars And Nuclear Physics, Yuri Cavecchi, D. K. Galloway, A. Heger, P. Santillán-Ortega, M. Nava-Callejas, F. M. Vincentelli, Liliana E. Rivera Sandoval, A. Goodwin, Z. Johnston

Physics & Astronomy Faculty Publications

When neutron stars accrete matter from a companion star, this matter forms a disk around them and eventually falls on their surface. Here, the fuel can ignite into bright flashes called Type I bursts. Theoretical calculations based on state-of-the-art nuclear reactions are able to explain many features of the bursts. However, models predict that the bursts should cease at high accretion rates, whereas in many sources they disappear at much lower rates. Moreover, their recurrence times also show strong discrepancies with predictions. Although various solutions have been proposed, none can account for all the observational constraints. Here, we describe a …

Osimertinib Activates A Tgf-Β2-Dependent Secretory Program That Drives Lung Adenocarcinoma Progression, Madhurima Ghosh, Chao Wu, Abhishek Kumar, Monique Nilsson, John V Heymach, Weina Zhao, Jiang Yu, Xin Liu, Na Ding, Shike Wang, Guan-Yu Xiao, Angelo Chen, Kate Grimley, William K Russell, Chad J Creighton, Xiaochao Tan, Jonathan M Kurie

Faculty, Staff and Student Publications

EGFR-mutant lung adenocarcinomas (LUADs) that are vulnerable to the EGFR antagonist osimertinib (Osi) eventually relapse, owing in part to the emergence of drug-tolerant persister (DTP) cells that arise through epigenetic mechanisms. Intratumoral DTP cells can herald a worse clinical outcome, but the way in which DTP cells influence LUAD progression remains unclear. Osi-resistant (OR) cells exhibit typical DTP cell features, including a propensity to undergo senescence and epithelial-mesenchymal transition (EMT), which can activate heightened secretory states. Therefore, we postulated that OR cells influence LUAD progression through paracrine mechanisms. To test this hypothesis, we utilized congenic pairs of EGFR-mutant LUAD cell …

Organising Care For Complexity: A Pathways Model For Adult Community Intellectual Disability Services, Rohit Shankar, Indermeet Sawhney, Samuel Tromans, Bhathika Perera, Laura Korb, Rory Sheehan, Heather Hanna, Richard Laugharne, Niall O'Kane, Jana Devilliers, Ganesan Rajagopal, Lance Watkins, Jane Mccarthy, Kiran Purandare, Regi Alexander, Ashok Roy, Asif Zia, Satheesh Gangadharan, Angela Hassiotis

Peninsula Medical School

Adult community intellectual disability services in the United Kingdom (UK) are required to deliver specialist, evidence-based care for a variety of conditions while minimising restrictive practices and reliance on inpatient provision. Care pathway models have emerged as a potential mechanism to reconcile these aims yet remain under-used in care philosophies in intellectual disabilities. We propose a generalisable pathways model for community intellectual disability services and examine its implications for policy, clinical practice, and research. The model integrates care navigation, proportionate specialist input, and defined clinical condition care including behaviours that challenge, mental and physical health, forensics, neurodevelopmental conditions, epilepsy, and …

A Prepositional Cycle In French, Fabienne Martin, Yining Nie, Artemis Alexiadou

Faculty Research, Scholarly, and Creative Activity

This paper discusses the morphosyntax and semantics of locative prepositions in French, with a particular focus on the prefix de-in complex prepositions (e.g., en dessous de [in from.under of] ‘below’) and in axial nominalizations (e.g., le dessous de [the from.under of] ‘the bottom part/region of’). We propose that in these formations, de-, which developed historically from an ablative marker, retains a Source semantics and lexicalizes the function PROJECT, which defines the region outward from the axial part of an object (Matushansky & Zwarts, 2019). We support our analysis with a corpus study on French child data showing that children acquiring …

The Advantages Of Saudi Arabia’S Fixed Exchange Rate Regime For Inflation Control: An Econometric And Empirical Analysis, Rodrigo Bochner

Arab Economic and Business Journal

Since 1986, Saudi, has maintained a fixed exchange rate, pegging the Saudi Riyal (SAR) to dollar at SAR 3.75/USD. This stabilizing domestic prices, and promoting macroeconomic stability in an oil-dependent and economy exposed to volatile global commodity prices and international shocks. This paper provides a assessment of the fixed exchange rate’s advantages for inflation control. Leveraging a dataset spanning 1980–2025 and econometric tools— Ordinary Least Squares (OLS), Vector Error Correction Models (VECM), Autoregressive Distributed Lag (ARDL) techniques, and GARCH models—this study identifies the causal channels and measures the peg’s impact on inflation dynamics, with a review of literature, confirming that …

The Use Of Acupuncture To Address Health Disparities In The Treatment Of Low Back Pain, Vivian Li, Alexander Reals, Deepa Manda, Elizabeth Loomis

Advances in Clinical Medical Research and Healthcare Delivery

Low back pain (LBP) is a leading cause of disability, and treatment often involves a combination of pharmacological and non-pharmacological therapies. Acupuncture is a medical treatment and ideology rooted in traditional Chinese medicine that utilizes applying small needles or pressure to specific points in the body. Utilized as an adjunct to supplement standard medical care, acupuncture is a procedure that can be done in a primary care setting. Multiple studies have shown efficacy in treating acute or chronic back pain, with up to 1.5% of the US population having used acupuncture at one point.

In the pursuit of holistic health, …

Evidence Based Management Of High Ldl-C For Prevention Of Atherosclerotic Cardiovascular Disease In Adult Patients In Resident Run Clinic: A Qi Project, Astha Prasai, Sahej Manesh Singh Arora, Hafsa Jawaid, Aakriti Jain, Omofolarin Babayale, Nauman Naeem, Hina Ukrani, Nawid Latifi, Binita Neupane, Soon-Il Song, Gaurav Sharma

Advances in Clinical Medical Research and Healthcare Delivery

Background:

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and in the United States, with significant healthcare and economic burden. Despite clear guideline recommendations, the implementation of ASCVD risk assessment and statin use for primary prevention remains suboptimal.

Methods:

A quality improvement project was conducted at a resident run clinic with an objective to improve ASCVD risk documentation and guideline-based lipid management. A total of 600 patients aged 40-75 years without a history of cardiovascular disease were randomly selected- 300 in the pre-intervention group and 300 in the post-intervention group. The intervention included didactic sessions and quick …

Rare Event: Neonatal Anaphylaxis Following Hepatitis B Vaccination – A Case Series From A Tertiary Care Center In India, Aarthi Ma, Revanth R

Advances in Clinical Medical Research and Healthcare Delivery

We report two cases of anaphylaxis following Hepatitis B vaccination in one-day-old neonates at a tertiary care hospital in India. Both cases presented with similar patterns of cutaneous reactions and respiratory symptoms shortly after intramuscular administration of the Hepatitis B vaccine. To our knowledge, this is among the few documented case series of neonatal anaphylaxis post–Hepatitis B vaccination, underscoring its rarity yet clinical importance. The cases highlight the critical importance of vigilant post-vaccination monitoring and prompt recognition of vaccine-associated adverse events in neonates. This report reviews current literature on anaphylaxis following vaccination and discusses optimal management strategies.

An Exploratory Study Of Social Determinants And Pediatric Lead Exposure In Chemung County, Ny, Jenna Mccracken, Anika Stundtner, Megan Kerbag, Madison Desantis, Jennifer Coseo, Richard Terry

Advances in Clinical Medical Research and Healthcare Delivery

Background: Lead exposure in children is a persistent public health concern due to its irreversible neurological and developmental effects. Children under 6 years old are particularly vulnerable due to frequent hand-to-mouth activity and increased environmental exposure. Existing literature suggests a relationship between adverse social determinants of health (SDOH), such as low parental education and residence in high-poverty areas, and elevated pediatric blood lead levels (BLLs). This study, subsidized through a community service grant from Excellus Blue Cross Blue Shield, aimed to examine the association between BLLs and SDOH among children screened at the ACCEL Community Health Clinic in Chemung County, …