Digital Commons Network^™

Colocalization And Functional Analyses Identify Gbe1 As A Gene Linking Muscle Strength And Cardiometabolic Fitness, Theresia M. Schnurr, Miranda L. Johnson, Christopher Jin, Kimmie V. Sørensen, Lindsey Kim, James W. Jahng, Amanda Ramste, Ewa Bielczyk-Maczynska, Michael J. Gloudemans, Peter Saliba-Gustafsson, Elena Vinton, Patrick L. Jurney, Ivan Carcamo-Orive, Euan A. Ashley, Torben Hansen, Joshua W. Knowles, Brian T. Palmisano

Faculty Research, Scholarly, and Creative Activity

Handgrip strength is a proxy for muscular fitness, an indicator for general health status, and is associated with cardiometabolic health. The mechanisms connecting handgrip strength to skeletal muscle function are incompletely understood. We applied integrated linkage-disequilibrium-adjusted colocalization analysis of genome-wide association study summary statistics for handgrip strength, combined with expression and splicing quantitative trait loci from skeletal muscle, and identified glycogen branching enzyme 1 (GBE1) as a candidate gene for handgrip strength. CRISPR-interference knockdown of GBE1 in immortalized human skeletal muscle cells (HMCL-7304) demonstrated decreased glycogen content and accumulation of polyglucosan bodies. Knockdown of GBE1 led to increased oxygen consumption …

Activin A Secretion By Muscle-Repairing Macrophages Induces Heterotopic Ossification In Mice, Wenqiang Yin, Kazuo Okamoto, Asuka Terashima, Warunee Pluemsakunthai, Takehito Ono, Taku Ito-Kureha, Shizuo Akira, Yoshinobu Hashizume, Roland Baron, Satoshi Ueha, Kouji Matsushima, Martin M Matzuk, Yuji Mishina, Hiroshi Takayanagi

Faculty, Staff and Students Publications

The immune system is not only essential for host defense, but it is also involved in tissue maintenance and disease pathogenesis. Macrophages play a key role in tissue repair, fibrosis, and tumorigenesis, but the mechanisms underlying their multifunctionality have not been fully explored. Here, we identified Mrep (Ly6ChiCX3CR1loPDPN+CD9+) as a crucial subset of macrophages for muscle regeneration after muscle injury. Muscle regeneration required Mrep-derived activin A, which was produced via the TLR4/TIR domain-containing adapter-inducing interferon-β/TANK-binding kinase 1/interferon regulatory factor 3/7 signaling pathway in response to muscle injury. Mrep exerted pathological effects by secreting activin A in a model of genetically …

Depression Due To Combined Dexamethasone And Cyproheptadine Abuse For Weight Gain, Sanjana Sateesh, Jatin Kumar, Dhananjay Ardawatia, Kishor M, Shashidhara Kc, Srikanth Ms

Digital Journal of Clinical Medicine

Cyproheptadine, an H1 antihistamine, and Dexamethasone, a long-acting steroid, are often misused in combination for addressing self-perceived body image issues and have become a popular but dangerous ‘weight gain cocktail’, often available over the counter without any prescription. This case describes a 25-year-old man who had self-prescribed the above-mentioned drugs in combination to address his self-perceived lean physique. This resulted in a significant weight gain, followed by an abnormal increase in appetite, which affected his daily life. Upon cessation, it resulted in rebound weight changes, depressive features, along with features of corticosteroid withdrawal, which required multidisciplinary management.

This case highlights …

Co-Electrospinning Polyacrylonitrile (Pan) / Polymer Of Intrinsic Microporosity-1 (Pim-1) For Electrochemical-Based Sensor For Pyridine Detection And Absorption, Samar A. Salim

Nanotechnology Research Centre

The electrospinning of the polymer of intrinsic microporosity-1 (PIM-1) poses challenges due to its limited solubility and tendency to form bead-like structures at high concentrations. This work details the synthesis and analysis of electrospun composite fibers made from polyacrylonitrile (PAN) and PIM-1 for electrochemical applications. The data analysis confirmed the successful incorporation of PIM-1 into the PAN matrix. The fiber characteristics were significantly influenced by PIM-1 loading (1–10%), resulting in fiber diameters ranging from 0.8 to 1.7 μm. A 10% concentration of PIM-1 results in the formation of macropores with diameters ranging from 0.5 to 1.7 μm. Optical analysis using …

Which Repair Technique, Bone Tunneling Or Suture Anchors, Is Superior When Performing Lesser Tuberosity Osteotomy At The Time Of Stemless Total Shoulder Arthroplasty?, Jared M. Mahylis, Stephaine J. Muh, Mahdi Mazeh, Emil Espinal Nunez, Daniel Oravec, Johnny Kasto, Chimdindu Obinero, Kai Zhu, Yener N. Yeni, Shariff K. Bishai

Conference Presentation Abstracts

INTRODUCTION: Total shoulder arthroplasty (TSA) has evolved as a treatment for advanced shoulder osteoarthrosis, with stemless implants gaining popularity due to reduced risks of stress shielding and complications associated with stemmed designs. However, the optimal technique for repairing the subscapularis during TSA remains under investigation. This study evaluates the biomechanical performance of two repair techniques—bone tunneling and suture anchors—used for Lesser Tuberosity Osteotomy (LTO) in the context of stemless TSA.  
METHODS: Ten shoulders from six cadaveric specimens (3 male, 3 female; aged 58–93) were prepared and allocated to bone tunneling or suture anchor repair groups. Cyclic loading tests were performed, …

Leveraging Csr To Buffer Brand Challenges During Crises: A Saudi Arabian Perspective, Nouf Alrayes, Abdullah Alhidari

Journal of Marketing and Consumer Behaviour in Emerging Markets

Crises, such as economic downturns or global health pandemics, pose significant business challenges. Engaging in CSR initiatives that contribute to societal well-being can help mitigate the negative consequences of crises, reinforce customer gratitude, and minimize corporate hypocrisy. CSR is critical in shaping a company’s accountability and ethical responsibilities. Consequently, there is an opportunity for the firm to see the role of CSR and how it affects customers’ responses and attitudes during any difficult situation. Drawing upon attribution theory and the customer gratitude reciprocity cycle, a conceptual framework was developed to test the impact of CSR on the variables: corporate hypocrisy, …

Comparison Of Integrated 3d Electroanatomic Mapping And Conventional Mapping Systems For Pentaspline Pulsed Field Ablation Of Atrial Fibrillation., Auroa Badin, Andrea K Robinson, Allyson Farrah, Saanvi Billakanty, David M Nemer, Ankur N Shah, Jaret D Tyler, Eugene Y Fu, Nagesh Chopra, Anish K Amin

Heart and Vascular Articles

INTRODUCTION: Pulsed field ablation (PFA) is an established therapy for atrial fibrillation (AF), yet optimal mapping strategies during pentaspline PFA remain uncertain. We compared procedural characteristics and material costs of an integrated 3D electroanatomic mapping (EAM) platform with conventional mapping systems.

METHODS AND RESULTS: In a multicenter observational study of 448 consecutive AF ablations done using pentaspline catheter (62 integrated mapping; 386 conventional mapping) performed between February 2024 and August 2025, baseline characteristics were similar between groups. Compared with conventional mapping, the integrated platform was associated with shorter total procedure time (49 ± 16 vs. 66 ± 26 min, p …

Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel

Faculty, Staff and Student Publications

Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the molecular regulation of this fate switch remains poorly understood. We report that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential. Shear stress remodels mitochondria in hemogenic endothelium by promoting mitochondrial gene transcription and protein synthesis. Laminar flow selectively initiates translation of 5' terminal polypyrimidine (5'TOP) motif-containing transcripts, which commonly encode ribosome and translation machinery. …

Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin

Faculty, Staff and Student Publications

Neuroinflammation, encompassing both innate and adaptive immune responses, plays a crucial role in ischemic stroke. Although B lymphocytes are central to adaptive immunity, their contributions to ischemic stroke remain poorly understood. Here, we demonstrated that B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures at the later stage after stroke, which mainly depended on in situ proliferation. This accumulation correlated with worsened neuroinflammation and ischemic injury, whereas B cell depletion reduced chronic brain damage during stroke. Mechanistically, microglia recruited B cells into ischemic lesions through MIF-CD74/CXCR4 signaling during the early phase of stroke, while IFN-related pathways in B cells …

Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye

Faculty, Staff and Student Publications

Dysregulation of cell cycle checkpoints is a cancer hallmark, with ubiquitination-controlled protein stability playing a pivotal role. Although p21, a key cyclin-dependent kinase inhibitor, is tightly regulated by ubiquitin-mediated degradation, the key upstream modulators of its ubiquitination remain incompletely defined. Here, we identify poly(ADP-ribose) glycohydrolase (PARG) as a regulator of p21 stability in gastric cancer (GC) cells. We show that PARG expression is markedly upregulated in GC tissues and correlates with poor patient prognosis. Functional assays revealed that genetic depletion of PARG triggers G2/M phase arrest and impairs GC cell proliferation. Mechanistically, we demonstrate that PARG loss enhances p21 PARylation, …

Surface Morphometrics Reveals Local Membrane Thickness Variation In Organellar Subcompartments, Michaela Medina, Ya-Ting Chang, Hamidreza Rahmani, Mark Frank, Zidan Khan, Daniel Fuentes, Frederick A Heberle, M Neal Waxham, Benjamin A Barad, Danielle A Grotjahn

Faculty, Staff and Student Publications

Lipid bilayers form the basis of organellar architecture, structure, and compartmentalization in the cell. Decades of biophysical, biochemical, and imaging studies on purified or in vitro-reconstituted liposomes have shown that variations in lipid composition influence the physical properties of membranes, such as thickness and curvature. However, similar studies characterizing these membrane properties within the native cellular context have remained technically challenging. Recent advancements in cellular cryo-electron tomography (cryo-ET) imaging enable high-resolution, three-dimensional views of native organellar membrane architecture preserved in near-native conditions. We previously developed a "Surface Morphometrics" pipeline that generates surface mesh reconstructions to model and quantify cellular membrane …

Lanthorn, Vol. 60, No. 12, March 2, 2026, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Medial Meniscus Root Repair Demonstrates Superior Radiographic And Clinical Outcomes At Long-Term Follow-Up Compared To Partial Medial Meniscetomy, Robert Dean, Ryan Mcnassor, Aaron John Krych, Brian R. Waterman

Conference Presentation Abstracts

INTRODUCTION: Posterior medial meniscus root tears (PMMRTs) are frequently observed injuries that lead to alterations in tibiofemoral biomechanics. Few long-term reviews have considered the long term clinical and radiographic outcomes of management of these injuries. This study sought to perform a systematic review and meta-analysis of the current literature on long term clinical and radiographic outcomes of PMMRTs. METHODS: Using PRISMA guidelines, a systematic review was performed with inclusion criteria of English language studies, diagnosis of PMMRT on MRI with confirmation on arthroscopy if managed operatively, studies with minimum 5-year radiographic or patient reported outcome metrics. Data including management strategy, …

The Development Of Ace-Iii Performance Validity Tests For Dementia Screening, Donnchadh Murphy, Rupert Noad

Peninsula Medical School

Objective: Performance validity tests (PVTs) are an essential component of a neuropsychological evaluation. There is a lack of brief validated PVTs for use alongside cognitive screening assessments for dementia. The current study sought to develop and evaluate a series of brief PVTs, which could be embedded into the Addenbrooke’s Cognitive Examination (ACE-III) and used in a dementia clinic. Method: This study used a diagnostic accuracy design to compare the performance of 31 individuals with Alzheimer’s disease dementia and 26 healthy older adults who simulated having Alzheimer’s disease. Participants were asked to complete ACE-III, the Test of Memory Malingering (TOMM), and …

Precision Measurement Of A Resistance Standard At Frequencies Up To 2 Mhz, Jurgen Schurr, Shakil A. Awan

School of Engineering, Computing and Mathematics

We report on two-terminal-pair and four-terminal-pair (4TP) measurements of a 10 kΩ resistance standard by means of a commercial precision inductance-capacitance-resistance meter (LCR meter) at frequencies up to 2 MHz. We discuss the effect of cables on a resistance standard measured in either two- or 4TP configuration and demonstrate within which uncertainty the effect of 2.5 m long measuring cables can be corrected accurately. Such long cables are inevitable for precision measurements of the quantum Hall resistance (QHR) at high frequencies. Furthermore, the systematic effects of the LCR meter, such as the internal input capacitances, voltage and frequency dependences, and …

Ndls Communicator: Week Of 03.02.26, Notre Dame Law School

NDLS Communicator

The Latest News

• Notre Dame Exoneration Justice Clinic Client Reginald “Reggie” Dillard Exonerated After 27 Years of Wrongful Imprisonment

Student News

• William Branson Donahue
• Dennis Wieboldt
• Perla Khattar
• Nicolás Buitrago-Rey

Faculty Briefs

• Carter Snead
• Diane Desierto
• Mary Ellen O'Connell
• Francisco Urbina
• Rick Garnett
• David McIlroy
• Paolo Carozza
• Ashley Sanchez

ND Law in the News

• Several outlets highlighted the Notre Dame Law School Exoneration Justice Clinic’s work in the exoneration of clinic client Reggie Dillard.

Events

• Law & Technology Seminar: Raúl Madrid, Professor of Law and Director of the Program on Law, Science, and Technology at the Pontificia Universidad Católica de …

Nursing Practice In Cancer Treatment Decision Making Among Older Adults: A Scoping Review On Behalf Of The International Society Of Geriatric Oncology Nursing, Allied Health, And Scientists Interest Group, Fay J. Strohschein, Hanneke Van Der Wal-Huisman, K. Alix Hayden, Kristen R. Haase, Michelle Hannan, Cindy Kenis, Juan Li, Nikita Nikita, Sophie Pilleron, Tracy Ruegg, Heike Schmidt, Anke Steckelberg, Cassandra Vonnes, Martine Puts

Department of Medical Oncology Faculty Papers

INTRODUCTION: Cancer treatment decision making (CTDM) presents important challenges among older adults due to variation in health and functional status, presence of comorbidities, differing goals/values, quality and quantity of life considerations, and limited inclusion in clinical trials. Nursing standards and guidelines call for competence in supporting CTDM and nurses advocate for greater involvement. However, clear understanding of the existing evidence to inform nursing practice is lacking. We aimed to map and synthesize evidence that provides insight into nursing practice in CTDM among older adults, with attention to nursing roles, required skills and competencies, potential barriers and facilitators, and outcomes studied. …

Population Analysis And Immunologic Landscape Of Melanoma In People Living With Hiv, Lindsay Barger, Derek Wang, Ashley Saravia, Valeria Mezzano, Gyles Ward, Cynthia Loomis, Carly Feldman, Madalina Tuluc, Rino Seedor, Peter Gaskill, Anna Coghill, Gita Suneja, Iman Dehzangi, Jennifer Hope, George Jour, Gabriele Romano

Department of Medical Oncology Faculty Papers

PURPOSE: To dissect the clinical and immunologic features of people living with human immunodeficiency virus (HIV; PLWH) diagnosed with melanoma, who have consistently shown worse outcomes than HIV-negative individuals (PLw/oH) with the same cancer.

EXPERIMENTAL DESIGN: We analyzed electronic health records from 1,087 PLWH and 394,437 PLw/oH with melanoma. Demographic and clinical characteristics were compared. Spatial immune transcriptomics (72 immune-related genes) was performed on melanoma tumor samples (n = 11), with downstream validation using multiplex immunofluorescence (mIF; n = 15 PLWH, n = 14 PLw/oH).

RESULTS: PLWH were diagnosed at a younger age, had a greater representation of Hispanic and …

Benevolence And Brutality: Evangelical Christianity & Child Welfare Social Work In Historical Perspective, Grace Pappas

School of Social Work Faculty Publications and Presentations

Evangelical Christians in the U.S. are a unique population with tremendous socio-political influence. While evangelicals have a unique interest in foster care and adoption, little social work scholarship explores intersections between evangelicalism and child welfare. Through an integrative literature review of 11 historical articles discussing evangelical Christianity and child welfare social work, I found the scholarship as a whole tended to emphasize evangelical Christians’ good intentions and deeds, while only limitedly discussing white supremacy, xenophobia, and settler colonialism. In light of these findings, I discuss potential implications and offer three invitations for further exploring this line of inquiry.

Editorial: Clinical Imaging, Neurophysiological, Neuropathology And Neuroethics Studies On Disorders Of Consciousness, Coma Mechanisms, And Theories Of Consciousness: A Unifying Attempt, Diego Iacono, Manuel Trachsel, Thanh Phan, Charlène Aubinet

Department of Neurology Faculty Papers

No abstract provided.

Influence Of Pulse Width On Energy Deposition And Temperature In Nanosecond-Pulsed Discharges, Christopher B. Reuter, Joshua B. Sinrud, Tanvir I. Farouk, Nicholas S. Dewey, Dmitri Kaganovich

Faculty Publications

Nanosecond-pulsed discharges are a promising method to enhance combustion but can generate significant levels of electromagnetic interference (EMI). Modifying the discharge pulse width is an unexplored option to reduce EMI, but few studies have examined how changing the pulse width affects discharge parameters such as energy and temperature. This study addresses this issue by systematically investigating how the pulse width affects the energy per pulse, breakdown time, rotational temperature, and vibrational temperature in air across different frequencies, flow velocities, and gap distances in a plasma-assisted flow tube. It is observed that the pulse width has a substantial impact on the …

Intouch Week Of March 2, 2026, New York Medical College

InTouch

• Kartik Prabhakaran, M.D., to Lead Department of Surgery
• Uncovering an Early Driver of Pulmonary Arterial Hypertension
• What if Banana Bags Came Ready to Use?
• NYMC and TU Host "Ninety Minutes: The Medical Magazine of the Web"
• Pet the Stress Away Brings Comfort to NYMC 
• Free Shipping on NYMC Gear
• Student Spotlight: Building an Orthopedic Future

Effect Of Temperature Variation On The Biological Treatment Of Greywater In The Sequencing Batch Reactor, Ruaa M. Younis, Saad M. Hasan

Engineering and Technology Journal

Greywater reuse is vital in water-scarce regions, yet effective treatment remains challenging due to variable organic loads and limited infrastructure. This study investigates the effect of temperature variation on the efficiency of a Sequencing Batch Reactor (SBR) in treating greywater under realistic conditions. Greywater samples collected from households in Mosul, Iraq, were treated in a bench-scale SBR operated at 10, 23, and 36 °C with cycle times of 6, 8, and 12 hours. The reactor included aeration, temperature control, and sludge recirculation. Treatment performance was assessed through COD, TSS, nitrate, and pH analysis in influent and effluent samples. Results showed …

How Euler Could Have Done It: Euler And A Heuristic Derivation Of The Prime Number Theorem, Alexander Aycock

Euleriana

We present an argument that leads to the formulation of the Prime Number Theorem that Euler could have given.

The Modern History Of The Basel Problem, John Campbell, Paul Levrie

Euleriana

The \emph{Basel problem} refers to the problem of determining a closed form for the infinite series $\frac{1}{1^2} + \frac{1}{2^2} + \cdots$. If we consider what mathematical results have the most peer-reviewed papers devoted to new ways of proving such results, Euler's formula $\frac{1}{1^2} + \frac{1}{2^2} + \cdots = \frac{\pi^2}{6}$ is certainly among the top of such results. This motivates our historical study of peer-reviewed papers based on proofs of Euler's formula, and we introduce what appears to be the most comprehensive and up-to-date and exhaustive catalogue of peer-reviewed, published papers in the 20th and 21st centuries devoted to or mainly …

Psychological Capital And Academic Burnout Among Students In Islamic Boarding Schools: The Mediating Effects Of Religious Coping And Academic Engagement, Bukhari Ahmad, Eko Sujadi

Buletin Konseling Inovatif

This study aims to examine the impact of psychological capital on academic burnout among Islamic boarding school students, with religious coping and academic engagement as mediating variables. A quantitative research method with survey design was employed. The population consisted of 102 students at the Madrasah Tsanawiyah level, and a sample of 80 students was determined using the Krejcie and Morgan formula. The sampling technique used was simple random sampling. Four validated research scales were adapted for data collection: the Oldenburg Burnout Inventory – Student Version (OLBI-S), Compound Psychological Capital Scale (PsyCap-12), The Brief RCOPE, and the Utrecht Work Engagement Scale …

Even Repdigits Are Not Perfect: Conclusions From Triangular Numbers, Uwe Hassler

Euleriana

Are there nontrivial repdigits that are perfect numbers? This note gives an answer: not for numbers smaller than $10^{1500}$. This finding follows from results for triangular numbers. Passing by, I review Euler's contributions on polygonal numbers.

About Infinite Algebraic Curves Whose Indefinite Lengths Equal An Elliptic Arc: An English Translation Of E780, Derek R. Aoki

Euleriana

Euler continues his study of algebraic curves with equal arc length, a subject to which he returned several times. After a brief review, he introduces an infinite family of curves with the same indefinite length as a given ellipse. However, this first family is by his own admission poorly motivated, so he derives directly a different but related family of curves with the same indefinite length as a given ellipse.

Sustainable Aviation Fuel (Saf) From Used Cooking Oil (Uco) In Egypt: Opportunities And Challenges., Lamiaa Abdallah

Mansoura Engineering Journal

Global aviation sector contributes nearly 2.5% of global CO2 emissions. Aviation is hard-to-decarbonize sector due to the high energy densities required for aircraft. Commercial aviation is fueled by kerosene-based jet fuel. Alternatives for this carbonbased fuel include electric batteries, hydrogen fuel, and SAF. Electric batteries have very low energy densities. Hydrogen would require a complete change of the aviation system, including fuel & airport infrastructure. SAF is the only viable option in the short to medium term. SAF is produced from sustainable feed-stocks (like agricultural oils), with no embodied carbon. Existing airplanes can use traditional fuel blended with up to …

Pma Dan Uupma Harapan Dan Kenyataan (Sebuah Telaah Mengenai Kebijaksanaan Penanaman Modal), T. Mulya Lubis, S.H., Ll.M.

Jurnal Hukum & Pembangunan

Abstract