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Strengthening Students' Political Thinking Skills By Researching The Annexation Of Texas, Rebecca Macon Bidwell, Jeremiah Clabough Apr 2026

Strengthening Students' Political Thinking Skills By Researching The Annexation Of Texas, Rebecca Macon Bidwell, Jeremiah Clabough

The Councilor: A National Journal of the Social Studies

The unit plan in this manuscript uses best practices from the C3 Framework published by the National Council for the Social Studies and Wayne Journell’s ideas about political thinking to engage students in discussion of the politics leading to the nomination of Governor James K. Polk as the Democratic Party nominee for president in the U.S. 1844 presidential election. Students explore the impact of candidates’ views of the annexation of Texas during this election as well as the influence of President Jackson on the nomination process in the Democratic Party. Ultimately, the election pitted Governor James K. Polk, the dark …


Making Social Studies Work In The Age Of Ai, Angelo Letizia Apr 2026

Making Social Studies Work In The Age Of Ai, Angelo Letizia

The Councilor: A National Journal of the Social Studies

The purpose of this paper is to first outline a more embedded stance toward AI use, which I have labeled invisible philosophy and history as DNA and use this embedded framework as a backdrop for a more concrete discussion of skills and dispositions in regard to the use of AI in the social studies classroom and beyond. This dual positioning, one more theoretical and one more concrete, calls attention to the fact that AI should not simply be seen as some flashy tool divorced from a more nuanced and embedded understanding of its role in society. A list of practical …


Hitler Must Be Killed: A Wwii Case Study, Jeffrey Byford, Presley Shilling, Alisha Milam Apr 2026

Hitler Must Be Killed: A Wwii Case Study, Jeffrey Byford, Presley Shilling, Alisha Milam

The Councilor: A National Journal of the Social Studies

Social studies education during the 1960s experienced an educational renaissance known as the new social studies movement. Over 50 projects were funded by the National Science Foundation or private corporations to interject a student-centered curriculum into K-12 classrooms during this period. Nearly 60 years later, can student-centered decision-making activities be used in an era of high-stakes testing and planned curriculum? This article attempts to rekindle students' interest in decision-making and discussion by exploring elements in Moral Reasoning: The Value of Life from the Harvard Social Studies Project (HSSP). The activity called "Hitler Must Be Killed" helped students bring the content …


The Purpose Death Serves: Trauma Analysis Of Human Sacrifices At El Pollo, Moche Valley, Peru, Rachel Witt, Gabriel Prieto, Alan Chachapoyas, John Verano, Luis Flores De La Oliva, Feren Castillo Apr 2026

The Purpose Death Serves: Trauma Analysis Of Human Sacrifices At El Pollo, Moche Valley, Peru, Rachel Witt, Gabriel Prieto, Alan Chachapoyas, John Verano, Luis Flores De La Oliva, Feren Castillo

Sociology and Anthropology Faculty Research

Human sacrifice is one of the most dramatic and enduring rituals known to ancient societies. Death of the victim represents the climax of the event because lethal violence produces vivid images that articulate power relations between the organizers, audience, and those sacrificed. This study reconstructs burial treatments, biological profiles, and trauma patterns on 49 human sacrifices excavated from the site El Pollo located 13 km from Chan Chan, the capital city of the Chimú Empire (AD 1050/1100–1450), in the Moche Valley, Peru. Children and adolescents (n = 31/37) exhibit cutmarks to the anterior chest, which mirror the victim profiles and …


Conceptualizing Cancel Culture In Marketing: Moral Policing In A Hyperconnected World, T. Andrew Poehlman, Sairah Abraham Apr 2026

Conceptualizing Cancel Culture In Marketing: Moral Policing In A Hyperconnected World, T. Andrew Poehlman, Sairah Abraham

AMTP Proceedings 2026

The dynamics of marketing in society have shifted. Brands no longer sit at a distance broadcasting messages; they now occupy the same social networks as people, speaking in a human voice and inviting quasi-personal relationships. In this environment, we argue that corporate cancel culture is best understood as moral policing of brands that have chosen to act like human nodes in social networks. Drawing on hierarchy research, we frame cancellations as “leveling” responses when high-status brands behave in ways that feel domineering, hypocritical, or extractive rather than prestige-based and service-oriented. Using Moral Foundations Theory, we show how diverse cancellations can …


Cultivating Teacher Agency: Professional Development For Culturally Sustaining Environmental Stem Education In South Texas, Uma Ganesan, Angela M. Chapman, Alexander Hernandez Apr 2026

Cultivating Teacher Agency: Professional Development For Culturally Sustaining Environmental Stem Education In South Texas, Uma Ganesan, Angela M. Chapman, Alexander Hernandez

Teaching and Learning Faculty Publications

This qualitative multiple-case study examined how culturally and linguistically sustaining environmental STEM (CLSE-STEM) professional development transformed in-service teachers' practices across three South Texas high schools serving predominantly Hispanic populations. Through a three-phase design, eight STEM teachers participated in sustained professional learning focused on implementing culturally situated, liberatory pedagogies addressing educational inequities. Data included focus group interviews, classroom observations, teacher-created curricula, and student artifacts collected from Spring 2024 to Spring 2025. Findings revealed five interconnected themes demonstrating teachers' evolution from deficit-based to asset-based approaches: place-based environmental stewardship, strategic translanguaging implementation, teacher agency development, enhanced student engagement, and elder knowledge integration. Results …


Probability Of Fentanyl Adulteration In Cocaine Selectively Decreases Cocaine Demand, Cecilia Nunez, Jin H Yoon, James Mackillop, Margaret C Wardle Apr 2026

Probability Of Fentanyl Adulteration In Cocaine Selectively Decreases Cocaine Demand, Cecilia Nunez, Jin H Yoon, James Mackillop, Margaret C Wardle

Faculty, Staff and Student Publications

Fentanyl-related, cocaine-overdose deaths have drastically increased, yet research on how people who use cocaine perceive fentanyl adulteration is limited. This study developed the novel Adulterated Cocaine Purchasing Task (ACocPT), a modification of the original Cocaine Purchasing Task, to quantify how people respond to fentanyl adulteration in cocaine. In the ACocPT, participants indicated how much cocaine they would purchase when cocaine had no (0%) vs. some (10%) probability of fentanyl adulteration. Study aims were: 1) determine how possible fentanyl adulteration affects cocaine demand, and 2) determine which individual characteristics predict continued demand for cocaine despite fentanyl adulteration. This Amazon Mechanical Turk …


Eyes Wide Shut: Sex Trafficking In The Black Community, Stephany Powell Apr 2026

Eyes Wide Shut: Sex Trafficking In The Black Community, Stephany Powell

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.


Listening To Survivors: A Community Conversation, Jonathan Jackson Apr 2026

Listening To Survivors: A Community Conversation, Jonathan Jackson

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.


Gynecological Effects Of Sex Trafficking, Tracey Sylvester Apr 2026

Gynecological Effects Of Sex Trafficking, Tracey Sylvester

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.


Introduction To Panelists: Sex Trafficking Of Black Women And Girls, Stephany Powell Apr 2026

Introduction To Panelists: Sex Trafficking Of Black Women And Girls, Stephany Powell

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.


Reply To Ozkok Et Al., Vikas Kannojiya, Akshita Sahni, Emily Eickhoff, Neha Zacharia, Nicole St Clair, Noah Schulz, Peter E Hammer, Pedro J Del Nido, Rahul H Rathod, David M Hoganson, Vijay Govindarajan Apr 2026

Reply To Ozkok Et Al., Vikas Kannojiya, Akshita Sahni, Emily Eickhoff, Neha Zacharia, Nicole St Clair, Noah Schulz, Peter E Hammer, Pedro J Del Nido, Rahul H Rathod, David M Hoganson, Vijay Govindarajan

Faculty, Staff and Student Publications

No abstract provided.


Associations Between Sociodemographic Predictors And Age Of Referral For Autism Spectrum Disorder (Asd) Diagnosis Since The Beginning Of The Covid-19 Pandemic, Mallika Mathur, Ruosha Li, Sandra Mckay, Christine Markham, Deepali K Ernest, Shreela Sharma Apr 2026

Associations Between Sociodemographic Predictors And Age Of Referral For Autism Spectrum Disorder (Asd) Diagnosis Since The Beginning Of The Covid-19 Pandemic, Mallika Mathur, Ruosha Li, Sandra Mckay, Christine Markham, Deepali K Ernest, Shreela Sharma

Faculty, Staff and Student Publications

Purpose: Sociodemographic characteristics, such as race and ethnicity, are associated with delays in ASD diagnosis. However, limited literature has examined the characteristics associated with delayed diagnosis since the start of the COVID-19 pandemic. This study aimed to identify the individual and aggregate sociodemographic characteristics associated with the age at which a child receives a referral for a diagnosis (from March 2020 to May 2023) and evaluate the impacts of the pandemic on this association.

Methods: Using cross-sectional data obtained from patients' electronic health records and the U.S. Census Bureau, we examined associations using linear regressions (N = 507). A subgroup …


Graphene Synthesis: A Reactor-Oriented Review Of Conventional And Emerging Production Methods, Paul C. Ani, Zeyad Zeitoun, Hasan J. Al-Abedi, Joseph D. Smith Apr 2026

Graphene Synthesis: A Reactor-Oriented Review Of Conventional And Emerging Production Methods, Paul C. Ani, Zeyad Zeitoun, Hasan J. Al-Abedi, Joseph D. Smith

Chemical and Biochemical Engineering Faculty Research & Creative Works

Graphene's unparalleled electrical, mechanical, and thermal properties have positioned it as a transformative material across diverse sectors, including electronics, energy storage, biomedicine, and environmental remediation. However, scalable, cost-effective, and high-quality production remains a critical challenge. This review presents a comprehensive, reactor-oriented analysis of both conventional and emerging graphene synthesis methods, categorized into top-down and bottom-up approaches. Special emphasis is placed on the role of reactor configurations in determining product quality, layer control, scalability, and economic viability. Key synthesis techniques explored include chemical vapor deposition (CVD), epitaxial growth, electrochemical exfoliation, ultrasonic-assisted methods, microwave reactors, combustion synthesis, and plasma-enhanced processes. By evaluating …


The De-Influencingtrend On Social Media And Its Impact On Consumer Engagement, Lana Waschka, Andre Waschka Apr 2026

The De-Influencingtrend On Social Media And Its Impact On Consumer Engagement, Lana Waschka, Andre Waschka

AMTP Proceedings 2026

Research has shown how influencer marketing in social media has been an effective way for companies to reach their target customers and advertise their products and services (Ahmad, 2018).   Brands rely on these influencers to promote products and encourage engagement and purchases.  De-Influencing, a seemingly antithetical concept, is a recent trend on social media where influencers are discouraging their followers from what they claim are unnecessary consumption.

By analyzing a data set of 216 observations from TikTok, we find evidence that influencers who use de-influencing appeals have higher post engagement. Specifics posts that use de-influencing strategies receive a higher number …


The Significance Of Vaccine Education In Vaccination Status, Emma Webb Apr 2026

The Significance Of Vaccine Education In Vaccination Status, Emma Webb

Honors College Theses

In recent years, more of the general population of the United States has become skeptical about vaccines and overall vaccination numbers have declined. Since the Covid-19 pandemic, vaccines have become somewhat of a controversial topic due to varying opinions about the adverse reactions and effectiveness of vaccines. The purpose of this study was to determine if there is a correlation between a person’s overall knowledge of vaccinations and a person’s vaccination status by asking a series of questions about the science used in vaccines and identifying the participant’s vaccination status in regards to influenza and Covid-19. This study also asked …


Analysis Of Live Load Distribution Factors In Prestressed Concrete Girder-Bridges With Asymmetric Losses In Prestressing Strands, Mohamed T. Elshazli, Mohamed Elgawady, Ahmed Ibrahim Apr 2026

Analysis Of Live Load Distribution Factors In Prestressed Concrete Girder-Bridges With Asymmetric Losses In Prestressing Strands, Mohamed T. Elshazli, Mohamed Elgawady, Ahmed Ibrahim

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asymmetric loss of prestressing strands in concrete bridge girders presents a critical yet underrecognized threat to structural integrity, particularly in exterior girders subjected to impact or localized deterioration. This form of localized and unbalanced damage leads to eccentric reductions in prestressing force, rotation of the principal axis, and diminished flexural capacity, effects not explicitly addressed in current design standards such as the AASHTO LRFD Bridge Design Specifications. This study presents a comprehensive numerical investigation into the structural implications of such asymmetric damage, focusing on its effect on live load distribution factors (LLDFs) across prestressed girder bridges. A parametric study of …


Late-Onset Legg-Calvé-Perthes Disease Treated With Varus Derotation Femoral Osteotomy: A Case Report, Mark Gamadia, Sami Habboub, Bianca Gamadia, Himanshu Panchal Apr 2026

Late-Onset Legg-Calvé-Perthes Disease Treated With Varus Derotation Femoral Osteotomy: A Case Report, Mark Gamadia, Sami Habboub, Bianca Gamadia, Himanshu Panchal

Student Publications

Introduction: Legg-Calvé-Perthes disease (LCPD) is categorized as idiopathic avascular necrosis of the femoral head, most common in children between the ages of 5 and 7. Prognosis is strongly influenced by age and lateral pillar classification, with children older than 8 years and those with Herring Group C disease typically experiencing poor outcomes. Delayed diagnosis represents a significant barrier to care, often limiting treatment options and worsening prognosis. This case highlights such a scenario while demonstrating that favorable functional and radiographic results remain achievable through meticulous surgical containment in late-presenting, severe disease.

Case report: An 11-year-old boy with no history of …


Behavioral-Centric Team Evaluation Via Consistent Rewards, Clement Kudakwashe Nyanhongo Apr 2026

Behavioral-Centric Team Evaluation Via Consistent Rewards, Clement Kudakwashe Nyanhongo

Dartmouth College Ph.D Dissertations

Across human domains ranging from sports to business and organizational settings, complex tasks are often solved by teams rather than individuals, leveraging benefits such as interaction, mutual support, complementary skills, cohesion, and task allocation. Evaluating team effectiveness, however, is inherently challenging due to the subjectivity of many existing techniques and the limitations of outcome-driven metrics that primarily focus on performance scores while overlooking the team processes that generated the scores. To address these challenges, this dissertation proposes a behavioral-centric, end-to-end framework for team evaluation grounded in reward functions that model sequential team behavior. Reward functions offer compact and interpretable representations …


Fronto-Cerebellar Features Associate With Cognitive Dysfunction In Childhood-Onset Systemic Lupus Erythematosus, Raquel Van Gool, Merve Koç Yekedüz, Lise Vrolix, Itamar Ronen, Vanessa Rameh, Kyle Mcbrearty, Aditi Deokar, Robert P Sundel, Eyal Muscal, Joseph Gonzalez-Heydrich, Andrea Knight, Joyce C Chang, Jaymin Upadhyay Apr 2026

Fronto-Cerebellar Features Associate With Cognitive Dysfunction In Childhood-Onset Systemic Lupus Erythematosus, Raquel Van Gool, Merve Koç Yekedüz, Lise Vrolix, Itamar Ronen, Vanessa Rameh, Kyle Mcbrearty, Aditi Deokar, Robert P Sundel, Eyal Muscal, Joseph Gonzalez-Heydrich, Andrea Knight, Joyce C Chang, Jaymin Upadhyay

Faculty, Staff and Students Publications

Objective: Cognitive dysfunction (CD) is a prevalent symptom in childhood-onset systemic lupus erythematosus (cSLE). This study aimed to investigate the neurobehavioral basis of CD in cSLE.

Methods: Patients with cSLE (N=20) and age- and sex-matched healthy controls (HCs, N=20) completed questionnaires and multiple neurocognitive tests. The Systemic Lupus Erythematosus Disease Activity Index 2000 and laboratory markers were used to monitor patients' clinical status. Neuroimaging assessments included functional near-infrared spectroscopy (fNIRS), functional magnetic resonance imaging (fMRI), and structural MRI.

Results: cSLE patients demonstrated moderate disease activity with high inflammation and immune dysregulation, alongside low medication adherence. Relative to HCs, cSLE patients …


Variability In The Orthopaedic Residency Trainee Trauma Surgical Experience, Zbigniew Gugala, Melvyn Harrington, Douglas R Dirschl Apr 2026

Variability In The Orthopaedic Residency Trainee Trauma Surgical Experience, Zbigniew Gugala, Melvyn Harrington, Douglas R Dirschl

Faculty, Staff and Students Publications

Background: The aim of this study was to analyze fracture fixation case logs from residents training at a level 1 trauma center to assess variability across residents' surgical experiences within a single residency program. The authors hypothesize that notable variability exists between residents' surgical experiences in fracture care.

Methods: A retrospective case series was conducted at a single, urban residency program with a level 1 trauma center. Completed case logs were collected from program graduates from 2022 to 2024. All surgical cases involving fracture fixation at the level 1 trauma center were included for analysis. The anatomic region of the …


Results Of A Randomized, Double-Masked, Placebo-Controlled Phase 1/2 Study Of A Trpv1 Antagonist Sjp-0132 In Participants With Dry Eye Disease Apr 2026

Results Of A Randomized, Double-Masked, Placebo-Controlled Phase 1/2 Study Of A Trpv1 Antagonist Sjp-0132 In Participants With Dry Eye Disease

Faculty, Staff and Students Publications

Purpose: To investigate the safety, tolerability, pharmacokinetic profile, and efficacy of SJP-0132 in participants with dry eye disease (DED).

Design: Phase 1/2, randomized, double-masked, single-center, placebo-controlled single and multiple ascending dose study.

Participants: Generally healthy adults aged ≥18 years with a patient-reported history of DED for ≥6 months, eye dryness visual analog scale (VAS: 0-100) ≥40 mm, 5-item dry eye questionnaire (DEQ-5) ≥6, and central corneal fluorescein staining (CFS) of 2 to 4 (Baylor scale: 0-5 for each of five zones).

Methods: This study consisted of Part A and Part B, containing four single- and two multiple-ascending dose cohorts, respectively. …


The International Pediatric Headache Didactic Series: A Novel Curriculum Innovation, Samantha L Irwin, Irene Patniyot Apr 2026

The International Pediatric Headache Didactic Series: A Novel Curriculum Innovation, Samantha L Irwin, Irene Patniyot

Faculty, Staff and Students Publications

Objectives: The International Pediatric Headache Didactic Series (IPHDS) was developed to provide free, comprehensive pediatric headache education to healthcare professionals worldwide. The objective of this study was to describe the design, implementation, and impact of this prospective educational intervention.

Background: Headache is the most common neurological symptom within the pediatric population. Yet, only nine fellowships are offered in pediatric headache medicine. Limitations in access to education and training are often cited as reasons for diagnostic and management barriers. To address this gap, the IPHDS was established in July 2022.

Methods: IPHDS is a recurring series consisting of 23 biweekly lectures. …


Driveline Infections Among Patients Supported With Left Ventricular Assist Devices: A Single Center Sixteen-Year Longitudinal Profile, Andrew Civitello, O Howard Frazier, Todd Rosengart, Kenneth Liao Apr 2026

Driveline Infections Among Patients Supported With Left Ventricular Assist Devices: A Single Center Sixteen-Year Longitudinal Profile, Andrew Civitello, O Howard Frazier, Todd Rosengart, Kenneth Liao

Faculty, Staff and Students Publications

Background: Left ventricular assist device (LVAD) driveline infections significantly impact patient outcomes. This study aimed to identify their risk factors.

Methods: We analyzed LVAD data from our institutional Intermacs database (January 1, 2008-December 31, 2023), combining primary implants and pump exchanges. Patient characteristics were summarized as frequencies for categorical variables and median (IQR) for continuous variables. The nature of repeated infection events was handled by the Andersen-Gill method within a multivariable Cox proportional hazards model for cause-specific hazard of driveline infections, accounting for death and heart transplant as competing risks.

Results: Our cohort included 1026 LVAD implants. Median patient age …


The Impact Of Estrogen Replacement During Perimenopause On Lung Function And Airway Inflammation In The Vcd Mouse Model, Joselyn Joanna Rojas Quintero, Francesca Polverino, John P Konhilas, Julie G Ledford Apr 2026

The Impact Of Estrogen Replacement During Perimenopause On Lung Function And Airway Inflammation In The Vcd Mouse Model, Joselyn Joanna Rojas Quintero, Francesca Polverino, John P Konhilas, Julie G Ledford

Faculty, Staff and Students Publications

Background:

Menopause associated asthma impacts a subset of women and is less responsive to current treatments. Mechanisms driving this late onset asthma are unknown. We recently developed a mouse model of menopause associated asthma using a combination of 4-Vinylcyclohexene Diepoxide (VCD) and House Dust Mite (HDM) exposures. The goal of this study was to determine how hormone replacement therapy during perimenopause impacts lung function and inflammation.

Methods:

The experimental groups included menopausal mice (VCD) with and without exposure to HDM (to model allergic airways disease) and menopausal mice with and without hormone replacement therapy (HRT; via estrogen pellet implantation). Lung …


Identifying The Strongest Novel Gene-Respiratory Disease Interactions For Rheumatoid Arthritis Risk, Xiaosong Wang, Elizabeth J Atkinson, John M Davis, Jeffrey A Sparks, James R Cerhan, Elena K Joerns, Robert Vassallo, Cynthia S Crowson Apr 2026

Identifying The Strongest Novel Gene-Respiratory Disease Interactions For Rheumatoid Arthritis Risk, Xiaosong Wang, Elizabeth J Atkinson, John M Davis, Jeffrey A Sparks, James R Cerhan, Elena K Joerns, Robert Vassallo, Cynthia S Crowson

Faculty, Staff and Students Publications

Objective: We aimed to identify the strongest individual gene-respiratory interactions for rheumatoid arthritis (RA) risk.

Methods: This case-control study used the Mayo Clinic (MC) and Mass General Brigham (MGB) biobanks for discovery and validation, respectively. We matched criteria-confirmed incident RA cases to four non-RA controls on age, sex, and duration electronic health record (EHR) history. Genetic exposures included known RA risk alleles. We identified respiratory diseases by codes and defined "respiratory burden" as the total number of respiratory codes divided by EHR duration before index date of RA. Using logistic regression models adjusting for potential confounders, we estimated odds ratios …


Robotic-Assisted Transumbilical Single-Site And Transvaginal Notes Resection Of Abdominal Wall Cesarean Scar Endometriosis: Two Case Reports, Chunhua Zhang Apr 2026

Robotic-Assisted Transumbilical Single-Site And Transvaginal Notes Resection Of Abdominal Wall Cesarean Scar Endometriosis: Two Case Reports, Chunhua Zhang

Faculty, Staff and Students Publications

No abstract provided.


Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat Apr 2026

Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat

Faculty, Staff and Students Publications

Background:

Sorting Nexin 27 (SNX27), a key regulator of synaptic receptor trafficking and endosomal recycling, has been implicated in maintaining synaptic homeostasis and cognitive function. To date, variants in SNX27 have been reported in a small number of patients across three publications with severe neurodevelopmental phenotypes. However, the genetic and functional landscape of SNX27-related disorders remains poorly understood, and further evidence is needed to confirm its association with disease and to better delineate the associated phenotype.

Methods and Results:

Two unrelated Pakistani families with a total of five affected individuals segregating a neurodevelopmental disorder were investigated via exome …


Kidney Disease And Heart Failure: Recent Advances And Current Challenges: Conclusions From A Kidney Disease: Improving Global Outcomes (Kdigo) Controversies Conference, Justin A Ezekowitz, Meg J Jardine, Sadiya S Khan, Magdalena Madero, Mark J Sarnak, Jozine M Ter Maaten, Michael Cheung, Jennifer M King, Morgan E Grams, Michel Jadoul, Nisha Bansal Apr 2026

Kidney Disease And Heart Failure: Recent Advances And Current Challenges: Conclusions From A Kidney Disease: Improving Global Outcomes (Kdigo) Controversies Conference, Justin A Ezekowitz, Meg J Jardine, Sadiya S Khan, Magdalena Madero, Mark J Sarnak, Jozine M Ter Maaten, Michael Cheung, Jennifer M King, Morgan E Grams, Michel Jadoul, Nisha Bansal

Faculty, Staff and Students Publications

Heart failure (HF) and chronic kidney disease (CKD) frequently coexist, which elevates the risks of hospitalization, disease progression, and death. Despite advances in treating each condition independently, many challenges remain in diagnosing and managing them in combination. In March 2024, Kidney Disease: Improving Global Outcomes (KDIGO) held the Controversies Conference on Kidney Disease and Heart Failure: Recent Advances and Current Challenges. Discussions highlighted the complex, bidirectional relationship between HF and CKD, including shared risk factors and overlapping pathophysiology as well as nuances in interpreting biomarkers such as natriuretic peptides and serum creatinine. Sodium-glucose cotransporter-2 inhibitors, renin-angiotensin-aldosterone system inhibitors, and emerging …


Feasibility Of A Large Language Model Chatbot To Support Parental Understanding In The Picu, Sriya Kakarla, Pamela Petersen, Shelley Kumar, Thomas Rappold, Sanjiv Mehta Apr 2026

Feasibility Of A Large Language Model Chatbot To Support Parental Understanding In The Picu, Sriya Kakarla, Pamela Petersen, Shelley Kumar, Thomas Rappold, Sanjiv Mehta

Faculty, Staff and Students Publications

Objectives: To evaluate the feasibility of a large language model (LLM)-based chatbot for answering parental questions in the PICU and inform design of a randomized controlled trial (RCT).

Design: Prospective single-arm feasibility study conducted from August 2024 to December 2024.

Setting: Quaternary PICU.

Subjects: Fourteen parents of children admitted to the PICU.

Interventions: Parents engaged in 10-minute sessions with a HIPAA-compliant GPT-4o- (Generative Pretrained Transformer 4o, OpenAI, San Francisco, CA) based chatbot prompted with patient-specific electronic health record (EHR) data.

Measurements and main results: Feasibility was assessed through four criteria: parental engagement and satisfaction, provider perceptions, accuracy and safety, and …