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Desirability Of Outcome Ranking For Obstetrical Trials: Illustration And Application To The Arrive Trial, Grecio J Sandoval, William A Grobman, Scott R Evans, Madeline M Rice, Rebecca G Clifton, Suneet P Chauhan, Maged M Costantine, Kelly S Gibson, Monica Longo, Torri D Metz, Emily S Miller, Samuel Parry, Uma M Reddy, Dwight J Rouse, Hyagriv N Simhan, John M Thorp, Alan T N Tita, George R Saade Mar 2024

Desirability Of Outcome Ranking For Obstetrical Trials: Illustration And Application To The Arrive Trial, Grecio J Sandoval, William A Grobman, Scott R Evans, Madeline M Rice, Rebecca G Clifton, Suneet P Chauhan, Maged M Costantine, Kelly S Gibson, Monica Longo, Torri D Metz, Emily S Miller, Samuel Parry, Uma M Reddy, Dwight J Rouse, Hyagriv N Simhan, John M Thorp, Alan T N Tita, George R Saade

Faculty, Staff and Student Publications

BACKGROUND: In randomized trials, 1 primary outcome is typically chosen to evaluate the consequences of an intervention, whereas other important outcomes are relegated to secondary outcomes. This issue is amplified for many obstetrical trials in which an intervention may have consequences for both the pregnant person and the child. In contrast, desirability of outcome ranking, a paradigm shift for the design and analysis of clinical trials based on patient-centric evaluation, allows multiple outcomes-including from >1 individual-to be considered concurrently.

OBJECTIVE: This study aimed to describe desirability of outcome ranking methodology tailored to obstetrical trials and to apply the methodology to …


Image-Based Multiplex Immune Profiling Of Cancer Tissues: Translational Implications A Report Of The International Immuno-Oncology Biomarker Working Group On Breast Cancer, Chowdhury Arif Jahangir, David B Page, Glenn Broeckx, Claudia A Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge S Reis-Filho, Amy Ly, Paul W Harms, Rajarsi R Gupta, Michael Vieth, Akira I Hida, Mohamed Kahila, Zuzana Kos, Paul J Van Diest, Sara Verbandt, Jeppe Thagaard, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Sylvia Adams, Jonas S Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R Bellolio, Vydehi Bheemaraju, Kim Rm Blenman, Luciana Botinelly Mendonça Fujimoto, Octavio Burgues, Alexandros Chardas, Maggie Chon U Cheang, Francesco Ciompi, Lee Ad Cooper, An Coosemans, Germán Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N Dudgeon, Mahmoud Elghazawy, Claudio Fernandez-Martín, Susan Fineberg, Stephen B Fox, Jennifer M Giltnane, Sacha Gnjatic, Paula I Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G Hanna, Aparna Harbhajanka, Steven N Hart, Johan Hartman, Stephen Hewitt, Hugo M Horlings, Zaheed Husain, Sheeba Irshad, Emiel Am Janssen, Tatsuki R Kataoka, Kosuke Kawaguchi, Andrey I Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L Kodach, Konstanty Korski, Guray Akturk, Ely Scott, Anikó Kovács, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K Lennerz, Marvin Lerousseau, Xiaoxian Li, Anant Madabhushi, Sai K Maley, Vidya Manur Narasimhamurthy, Douglas K Marks, Elizabeth S Mcdonald, Ravi Mehrotra, Stefan Michiels, Durga Kharidehal, Fayyaz Ul Amir Afsar Minhas, Shachi Mittal, David A Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D Perera, Christopher J Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T Rau, Joana M Ribeiro, David Rimm, Anne Vincent-Salomon, Joel Saltz, Shahin Sayed, Evangelos Hytopoulos, Sarah Mahon, Kalliopi P Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E Aubrey Thompson, Trine Tramm, William T Tran, Jeroen Van Der Laak, Gregory E Verghese, Giuseppe Viale, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y Wen, Wentao Yang, Yinyin Yuan, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Elisabeth Specht Stovgaard, Roberto Salgado, William M Gallagher, Arman Rahman Mar 2024

Image-Based Multiplex Immune Profiling Of Cancer Tissues: Translational Implications A Report Of The International Immuno-Oncology Biomarker Working Group On Breast Cancer, Chowdhury Arif Jahangir, David B Page, Glenn Broeckx, Claudia A Gonzalez, Caoimbhe Burke, Clodagh Murphy, Jorge S Reis-Filho, Amy Ly, Paul W Harms, Rajarsi R Gupta, Michael Vieth, Akira I Hida, Mohamed Kahila, Zuzana Kos, Paul J Van Diest, Sara Verbandt, Jeppe Thagaard, Reena Khiroya, Khalid Abduljabbar, Gabriela Acosta Haab, Balazs Acs, Sylvia Adams, Jonas S Almeida, Isabel Alvarado-Cabrero, Farid Azmoudeh-Ardalan, Sunil Badve, Nurkhairul Bariyah Baharun, Enrique R Bellolio, Vydehi Bheemaraju, Kim Rm Blenman, Luciana Botinelly Mendonça Fujimoto, Octavio Burgues, Alexandros Chardas, Maggie Chon U Cheang, Francesco Ciompi, Lee Ad Cooper, An Coosemans, Germán Corredor, Flavio Luis Dantas Portela, Frederik Deman, Sandra Demaria, Sarah N Dudgeon, Mahmoud Elghazawy, Claudio Fernandez-Martín, Susan Fineberg, Stephen B Fox, Jennifer M Giltnane, Sacha Gnjatic, Paula I Gonzalez-Ericsson, Anita Grigoriadis, Niels Halama, Matthew G Hanna, Aparna Harbhajanka, Steven N Hart, Johan Hartman, Stephen Hewitt, Hugo M Horlings, Zaheed Husain, Sheeba Irshad, Emiel Am Janssen, Tatsuki R Kataoka, Kosuke Kawaguchi, Andrey I Khramtsov, Umay Kiraz, Pawan Kirtani, Liudmila L Kodach, Konstanty Korski, Guray Akturk, Ely Scott, Anikó Kovács, Anne-Vibeke Laenkholm, Corinna Lang-Schwarz, Denis Larsimont, Jochen K Lennerz, Marvin Lerousseau, Xiaoxian Li, Anant Madabhushi, Sai K Maley, Vidya Manur Narasimhamurthy, Douglas K Marks, Elizabeth S Mcdonald, Ravi Mehrotra, Stefan Michiels, Durga Kharidehal, Fayyaz Ul Amir Afsar Minhas, Shachi Mittal, David A Moore, Shamim Mushtaq, Hussain Nighat, Thomas Papathomas, Frederique Penault-Llorca, Rashindrie D Perera, Christopher J Pinard, Juan Carlos Pinto-Cardenas, Giancarlo Pruneri, Lajos Pusztai, Nasir Mahmood Rajpoot, Bernardo Leon Rapoport, Tilman T Rau, Joana M Ribeiro, David Rimm, Anne Vincent-Salomon, Joel Saltz, Shahin Sayed, Evangelos Hytopoulos, Sarah Mahon, Kalliopi P Siziopikou, Christos Sotiriou, Albrecht Stenzinger, Maher A Sughayer, Daniel Sur, Fraser Symmans, Sunao Tanaka, Timothy Taxter, Sabine Tejpar, Jonas Teuwen, E Aubrey Thompson, Trine Tramm, William T Tran, Jeroen Van Der Laak, Gregory E Verghese, Giuseppe Viale, Noorul Wahab, Thomas Walter, Yannick Waumans, Hannah Y Wen, Wentao Yang, Yinyin Yuan, John Bartlett, Sibylle Loibl, Carsten Denkert, Peter Savas, Sherene Loi, Elisabeth Specht Stovgaard, Roberto Salgado, William M Gallagher, Arman Rahman

Faculty, Staff and Student Publications

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour …


The Risk And Burden Of Thromboembolic And Hemorrhagic Events In Patients With Malignant Gliomas Receiving Bevacizumab, Pushan Dasgupta, Alexander Ou, Heather Lin, Timothy Gregory, Kristin D Alfaro-Munoz, Ying Yuan, Vahid Afshar-Khargan, Carlos Kamiya-Matsuoka, Justin F Rousseau, Nazanin K Majd Mar 2024

The Risk And Burden Of Thromboembolic And Hemorrhagic Events In Patients With Malignant Gliomas Receiving Bevacizumab, Pushan Dasgupta, Alexander Ou, Heather Lin, Timothy Gregory, Kristin D Alfaro-Munoz, Ying Yuan, Vahid Afshar-Khargan, Carlos Kamiya-Matsuoka, Justin F Rousseau, Nazanin K Majd

Faculty, Staff and Student Publications

Purpose: Bevacizumab has evolved as an integral treatment option for patients with high-grade gliomas. Little is known about clinical risk factors that predispose patients with high-grade gliomas receiving bevacizumab to VTE or ICH. We sought to characterize the clinical risk factors associated with risk of either event.

Methods: In this multi-institutional retrospective study, we first evaluated patients with high-grade gliomas who were treated with bevacizumab at University of Texas MD Anderson Cancer Center from 2015-2021. We compared clinical and treatment-related factors among three cohorts: those who developed VTE, ICH, or neither. We further compared survival outcomes of these patients from …


A Phase I Study Of Docetaxel Plus Synthetic Lycopene In Metastatic Prostate Cancer Patients, Michael B Lilly, Chunli Wu, Yu Ke, Wen-Pin Chen, Adam C Soloff, Kent Armeson, Noriko N Yokoyama, Xiaotian Li, Liankun Song, Ying Yuan, Christine E Mclaren, Xiaolin Zi Mar 2024

A Phase I Study Of Docetaxel Plus Synthetic Lycopene In Metastatic Prostate Cancer Patients, Michael B Lilly, Chunli Wu, Yu Ke, Wen-Pin Chen, Adam C Soloff, Kent Armeson, Noriko N Yokoyama, Xiaotian Li, Liankun Song, Ying Yuan, Christine E Mclaren, Xiaolin Zi

Faculty, Staff and Student Publications

Purpose: Our preclinical studies showed that lycopene enhanced the anti-prostate cancer efficacy of docetaxel in animal models. A phase I trial (NCT0149519) was conducted to identify an optimum dose of synthetic lycopene in combination with docetaxel (and androgen blockade [androgen deprivation therapy, ADT]), and to evaluate its effect on the safety and pharmacokinetics of docetaxel in men with metastatic prostate cancer.

Methods: Subjects were treated with 21-day cycles of 75 mg/m2 docetaxel (and ADT), plus lycopene at 30, 90 or 150 mg/day. A Bayesian model averaging continual reassessment method was used to guide dose escalation. Pharmacokinetics of docetaxel …


Prenatal Vs Postnatal Diagnosis Of 22q112 Deletion Syndrome: Cardiac And Noncardiac Outcomes Through 1 Year Of Age, Lindsay R Freud, Stephanie Galloway, T Blaine Crowley, Julie Moldenhauer, Ann Swillen, Jeroen Breckpot, Antoni Borrell, Neeta L Vora, Bettina Cuneo, Hilary Hoffman, Lisa Gilbert, Beata Nowakowska, Maciej Geremek, Anna Kutkowska-Kaźmierczak, Joris R Vermeesch, Koen Devriendt, Tiffany Busa, Sabine Sigaudy, Trisha Vigneswaran, John M Simpson, Jeffrey Dungan, Nina Gotteiner, Karl-Philipp Gloning, Maria Cristina Digilio, Marta Unolt, Carolina Putotto, Bruno Marino, Gabriela Repetto, Magdalena Fadic, Sixto Garcia-Minaur, Ana Achón Buil, Mary Ann Thomas, Deborah Fruitman, Taylor Beecroft, Pui Wah Hui, Solveig Oskarsdottir, Rachael Bradshaw, Amanda Criebaum, Mary E Norton, Tiffany Lee, Miwa Geiger, Leslie Dunnington, Jacqueline Isaac, Louise Wilkins-Haug, Lindsey Hunter, Claudia Izzi, Marika Toscano, Tullio Ghi, Julie Mcglynn, Francesca Romana Grati, Beverly S Emanuel, Kimberly Gaiser, J William Gaynor, Elizabeth Goldmuntz, Daniel E Mcginn, Erica Schindewolf, Oanh Tran, Elaine H Zackai, Qi Yan, Anne S Bassett, Ronald Wapner, Donna M Mcdonald-Mcginn Mar 2024

Prenatal Vs Postnatal Diagnosis Of 22q112 Deletion Syndrome: Cardiac And Noncardiac Outcomes Through 1 Year Of Age, Lindsay R Freud, Stephanie Galloway, T Blaine Crowley, Julie Moldenhauer, Ann Swillen, Jeroen Breckpot, Antoni Borrell, Neeta L Vora, Bettina Cuneo, Hilary Hoffman, Lisa Gilbert, Beata Nowakowska, Maciej Geremek, Anna Kutkowska-Kaźmierczak, Joris R Vermeesch, Koen Devriendt, Tiffany Busa, Sabine Sigaudy, Trisha Vigneswaran, John M Simpson, Jeffrey Dungan, Nina Gotteiner, Karl-Philipp Gloning, Maria Cristina Digilio, Marta Unolt, Carolina Putotto, Bruno Marino, Gabriela Repetto, Magdalena Fadic, Sixto Garcia-Minaur, Ana Achón Buil, Mary Ann Thomas, Deborah Fruitman, Taylor Beecroft, Pui Wah Hui, Solveig Oskarsdottir, Rachael Bradshaw, Amanda Criebaum, Mary E Norton, Tiffany Lee, Miwa Geiger, Leslie Dunnington, Jacqueline Isaac, Louise Wilkins-Haug, Lindsey Hunter, Claudia Izzi, Marika Toscano, Tullio Ghi, Julie Mcglynn, Francesca Romana Grati, Beverly S Emanuel, Kimberly Gaiser, J William Gaynor, Elizabeth Goldmuntz, Daniel E Mcginn, Erica Schindewolf, Oanh Tran, Elaine H Zackai, Qi Yan, Anne S Bassett, Ronald Wapner, Donna M Mcdonald-Mcginn

Faculty, Staff and Student Publications

Background: The 22q11.2 deletion syndrome is the most common microdeletion syndrome and is frequently associated with congenital heart disease. Prenatal diagnosis of 22q11.2 deletion syndrome is increasingly offered. It is unknown whether there is a clinical benefit to prenatal detection as compared with postnatal diagnosis.

Objective: This study aimed to determine differences in perinatal and infant outcomes between patients with prenatal and postnatal diagnosis of 22q11.2 deletion syndrome.

Study design: This was a retrospective cohort study across multiple international centers (30 sites, 4 continents) from 2006 to 2019. Participants were fetuses, neonates, or infants with a genetic diagnosis of 22q11.2 …


False Conscience: Sustainability And Smart Evolution—Between Law And Power, Ugo Mattei Mar 2024

False Conscience: Sustainability And Smart Evolution—Between Law And Power, Ugo Mattei

Faculty Scholarship

The contribution describes the legal phenomenon as a playing field characterized by a progressive regression of the law, understood as a sovereign will from top to bottom, both in the vision of formalist legal positivisms in continental Europe and in realist terms, in the United States. Soft law represents the main strategy to subordinate the law to the interests of the economy, elasticizing environmental law, making it favorable to the market, reducing ecology to the simplistic metric of CO2 emissions. The consequence is a retreat of the statist vertical normativity of law which is not replaced by a de facto …


Can Steam Be Usable As A "Plus" For Ventilation Shutdown?, A. V. Mendoza, S. Weimer, Z. Williams Mar 2024

Can Steam Be Usable As A "Plus" For Ventilation Shutdown?, A. V. Mendoza, S. Weimer, Z. Williams

Poultry Science Faculty Publications and Presentations

The American Veterinary Medical Association (AVMA), preferred depopulation methods (i.e., foam, containerized gassing, and mechanical methods) can be challenging when depopulating cage and aviary commercial laying hen houses for multiple reasons. When preferred methods are not feasible or resources are unavailable, ventilation shutdown plus (VSD+) heat and/or carbon dioxide (CO2) is approved for emergency situations. Both recognized “pluses” work but can have issues as VSD+ heat typically causes a decrease in environmental humidity and can affect PVC structures, while CO2 can be a human safety concern and has procurement problem during emergencies. …


Analysis Of Letters To The Three Wise Men: Myth And Rite Transferred To Brands, Ainhoa García-Rivero, Belén Moreno-Albarracín Mar 2024

Analysis Of Letters To The Three Wise Men: Myth And Rite Transferred To Brands, Ainhoa García-Rivero, Belén Moreno-Albarracín

Faculty Research, Scholarly, and Creative Activity

In Spain, approximately 75% of toy sales are concentrated at Christmas (Asociación Española de Fabricantes de Juguetes, 2022). Taking into account this data, it is inevitable to talk about the importance of the Three Wise Men. Every year, boys and girls write their letters with the illusion of waking up on January 6 with gifts in their living rooms. In this context, it is opportune to analyze these letters in order to know the nature of the children's requests in their letters to the Three Wise Men. For this reason, the present work offers a content analysis of 417 letters, …


Applications Of Information Literacy To Teaching Independent Music Analysis, Katrina Roush Mar 2024

Applications Of Information Literacy To Teaching Independent Music Analysis, Katrina Roush

School of Music Faculty Publications

Undergraduate and graduate music students learn many tools beneficial for music analysis, and they practice applying these tools to music in their music theory classes. However, they often struggle to perform useful analysis on their own without the guidance of an instructor. They can have trouble understanding that analysis should communicate their personal interpretation of a work, and they may not realize that independent analysis usually requires some preparatory work (analytical research),such as discovering if others have analyzed the work and learning new analytical methods. This article shows that there is a strong connection between various steps in the music-analytical …


Tuberculosis In People Of Ukrainian Origin In The European Union And The European Economic Area, 2019 To 2022, Krista Stoycheva, Veronica Cristea, Csaba Ködmön, Senia Rosales-Klintz, Dominik Zenner, Anca Vasiliu, Marieke Van Der Werf, Christoph Lange Mar 2024

Tuberculosis In People Of Ukrainian Origin In The European Union And The European Economic Area, 2019 To 2022, Krista Stoycheva, Veronica Cristea, Csaba Ködmön, Senia Rosales-Klintz, Dominik Zenner, Anca Vasiliu, Marieke Van Der Werf, Christoph Lange

Faculty, Staff and Students Publications

Approximately five million Ukrainians were displaced to the EU/EEA following the Russian invasion of Ukraine. While tuberculosis (TB) notification rates per 100,000 Ukrainians in the EU/EEA remained stable, the number of notified TB cases in Ukrainians increased almost fourfold (mean 2019-2021: 201; 2022: 780). In 2022, 71% cases were notified in three countries, and almost 20% of drug-resistant TB cases were of Ukrainian origin. Targeted healthcare services for Ukrainians are vital for early diagnosis and treatment, and preventing transmission.


Interrelationships Among The Rice Export Prices Of Major Exporting Countries: In Search Of The Leader And Followers, Khondoker Abdul Mottaleb, Alvaro Durand-Morat Mar 2024

Interrelationships Among The Rice Export Prices Of Major Exporting Countries: In Search Of The Leader And Followers, Khondoker Abdul Mottaleb, Alvaro Durand-Morat

Agricultural Economics and Agribusiness Faculty Publications and Presentations

By examining the econometric interrelationships of rice export prices of India, Thailand, Vietnam, Pakistan, the U.S., Argentina, Brazil, and Uruguay, this study examines the most influential rice-exporting countries in the international rice export market. The sampled countries are the source of more than 80% of the global rice exports. In the process, this study relies on online data portals of the United Nations and country-level sources for aromatic and non-aromatic rice export price information from India, Pakistan, and Thailand. This study employed the Prais-Winsten and Autoregressive Distributive Lag (ARDL) estimation processes with the error correction procedure. Combining the findings from …


Venovenous Extracorporeal Membrane Oxygenation Usage Following Bullet Embolism To The Pulmonary Artery, Jonathan E. Schoen, Brian Carr, Murtuza Ali, Brett Chapman, Alan Marr, Lance Stuke, Patrick Greiffenstein, John P. Hunt, Paige Deville, Alison Smith Mar 2024

Venovenous Extracorporeal Membrane Oxygenation Usage Following Bullet Embolism To The Pulmonary Artery, Jonathan E. Schoen, Brian Carr, Murtuza Ali, Brett Chapman, Alan Marr, Lance Stuke, Patrick Greiffenstein, John P. Hunt, Paige Deville, Alison Smith

School of Medicine Faculty Publications

Background: Pulmonary artery embolus is a rare complication following gunshot wounds that creates a unique and serious challenge for trauma surgeons. While the majority of bullets that embolize through the vascular system end in the peripheral circulation, approximately one-third enter the central venous circulation. Case Report: We present the case of a bullet embolus to the left pulmonary artery following gunshot wounds to the right chest and the abdomen, with the abdominal ballistic traversing the liver before entering the vena cava and embolizing. The patient’s course was complicated by the development of severe acute respiratory distress syndrome that was successfully …


Demand Pull Versus Resource Push Training Approaches To Entrepreneurship: A Field Experiment, Simone Santamaria, Niloofar Abolfathi, Ishtiag Pasha Mahmood Mar 2024

Demand Pull Versus Resource Push Training Approaches To Entrepreneurship: A Field Experiment, Simone Santamaria, Niloofar Abolfathi, Ishtiag Pasha Mahmood

Research Collection Lee Kong Chian School Of Business

We compare the efficacy of two broad approaches to entrepreneurship training: a training prioritizing demand-side activities versus a training prioritizing resource-side activities. We do so by running a field experiment inside a 6-month entrepreneurship program involving 236 early-stage entrepreneurs. Inspired by our training, the first group invested more time interacting with potential customers and developing a deep understanding of customer needs and problems. The other group, in contrast, spent more time identifying and exploiting their core resources such as their network. Our results reveal that the training prioritizing demand-side activities is substantially more effective. At the end of the program, …


Invisible Inequalities: Barriers, Challenges, And Opportunities, Hari Bapuji, Gokhan Ertug, Vivek Soundarajan, Jason D. Shaw Mar 2024

Invisible Inequalities: Barriers, Challenges, And Opportunities, Hari Bapuji, Gokhan Ertug, Vivek Soundarajan, Jason D. Shaw

Research Collection Lee Kong Chian School Of Business

Inequality is a grand challenge of our times, and management researchers have responded by examining the relationship between business and societal economic inequalities. This research has enhanced our understanding of the nature, sources, and consequences of inequalities, as well as identified actions to address them. However, this effort has predominantly revolved around visible inequalities. We seek to direct greater scholarly attention to invisible inequalities – uneven possession of and access to resources and opportunities to engage in value creation, appropriation, and distribution based on attributes and characteristics that are not readily apparent or noticeable. Expanding the scope of investigations to …


Clinical Characteristics Of People With Intellectual Disability Admitted To Hospital With Constipation: Identifying Possible Specific High‐Risk Factors, R Laugharne, M Wilcock, J Rees, D Wainwright, Et Al Mar 2024

Clinical Characteristics Of People With Intellectual Disability Admitted To Hospital With Constipation: Identifying Possible Specific High‐Risk Factors, R Laugharne, M Wilcock, J Rees, D Wainwright, Et Al

Peninsula Medical School

Background People with intellectual disabilities (ID) die on an average 20 years earlier to the general population. They have higher rates of multimorbidity and polypharmacy. Around 25% of people with ID report chronic constipation. The England Learning Disabilities Mortality Review found that nearly 25% of deaths identified constipation as a long-term health problem. However, the likely risk factors for constipation related harm are poorly enumerated. We sought to identify possible specific high-risk factors by examining the clinical characteristics of people with ID admitted to hospital with constipation. Methods Data of people with ID admitted with constipation in two general hospitals …


Evidencing Occupational Therapy In Primary Care, Mary Hickson, Miranda Cunningham, Sam Wakley, Alison Warren, Avril Collinson Mar 2024

Evidencing Occupational Therapy In Primary Care, Mary Hickson, Miranda Cunningham, Sam Wakley, Alison Warren, Avril Collinson

School of Health Professions

A group of lecturers and researchers, from occupational therapyand dietetics, look at the evidence base for the effectiveness ofoccupational therapy interventions in primary care. They arguethat this is in its infancy and call for further service evaluation andresearch.


A Comparison Of The Effectiveness Of Cognitive Behavioural Interventions Based On Delivery Features For Elevated Symptoms Of Depression In Adolescents: A Systematic Review, Gretchen Bjornstad, Shreya Sonthalia, Benjamin Rouse, Leanne Freeman, Natasha Hessami, Jo Hickman Dunne, Nick Axford Mar 2024

A Comparison Of The Effectiveness Of Cognitive Behavioural Interventions Based On Delivery Features For Elevated Symptoms Of Depression In Adolescents: A Systematic Review, Gretchen Bjornstad, Shreya Sonthalia, Benjamin Rouse, Leanne Freeman, Natasha Hessami, Jo Hickman Dunne, Nick Axford

Peninsula Medical School

Background: Depression is a public health problem and common amongst adolescents. Cognitive behavioural therapy (CBT) is widely used to treat adolescent depression but existing research does not provide clear conclusions regarding the relative effectiveness of different delivery modalities. Objectives: The primary aim is to estimate the relative efficacy of different modes of CBT delivery compared with each other and control conditions for reducing depressive symptoms in adolescents. The secondary aim is to compare the different modes of delivery with regard to intervention completion/attrition (a proxy for intervention acceptability). Search Methods: The Cochrane Depression, Anxiety and Neurosis Clinical Trials Register was …


Navigating The Complexity Of Applying Nutrition Evidence To Individualised Care: Summary Of An Academy Of Nutrition Sciences Position Paper, Judith Buttriss, Mary Hickson, Kevin Whelan, Christine Williams Mar 2024

Navigating The Complexity Of Applying Nutrition Evidence To Individualised Care: Summary Of An Academy Of Nutrition Sciences Position Paper, Judith Buttriss, Mary Hickson, Kevin Whelan, Christine Williams

School of Health Professions

No abstract provided.


Clinical And Biomechanical Effectiveness Of Foot‐Ankle Exercise Programs And Weight‐Bearing Activity In People With Diabetes And Neuropathy: A Systematic Review And Meta‐Analysis, Netten Jj Van, Isabel C.N. Sacco, Lawrence Lavery, M Monteiro‐Soares, Joanne Paton, Anne Rasmussen, Anita Raspovic, Sicco A. Bus Mar 2024

Clinical And Biomechanical Effectiveness Of Foot‐Ankle Exercise Programs And Weight‐Bearing Activity In People With Diabetes And Neuropathy: A Systematic Review And Meta‐Analysis, Netten Jj Van, Isabel C.N. Sacco, Lawrence Lavery, M Monteiro‐Soares, Joanne Paton, Anne Rasmussen, Anita Raspovic, Sicco A. Bus

School of Health Professions

Background. Most interventions to prevent foot ulcers in people with diabetes do not seek to reverse the foot abnormalities that led to the ulcer. Foot‐ankle exercise programs target these clinical and biomechanical factors, such as protective sensation and mechanical stress. Multiple RCTs exist investigating the effectiveness of such programs, but these have never been summarised in a systematic review and meta‐analysis. Methods. We searched the available scientific literature in PubMed, EMBASE, CINAHL, Cochrane databases and trial registries for original research studies on foot‐ankle exercise programs for people with diabetes at risk of foot ulceration. Both controlled and non‐controlled studies were …


Prevention Of Foot Ulcers In Persons With Diabetes At Risk Of Ulceration: A Systematic Review And Meta‐Analysis, Netten Jj Van, Anita Raspovic, Lawrence A. Lavery, M Monteiro‐Soares, Joanne Paton, Anne Rasmussen, Isabel C.N. Sacco, Sicco A. Bus Mar 2024

Prevention Of Foot Ulcers In Persons With Diabetes At Risk Of Ulceration: A Systematic Review And Meta‐Analysis, Netten Jj Van, Anita Raspovic, Lawrence A. Lavery, M Monteiro‐Soares, Joanne Paton, Anne Rasmussen, Isabel C.N. Sacco, Sicco A. Bus

School of Health Professions

Aims Prevention of foot ulcers in persons with diabetes is important to help reduce the substantial burden on both individual and health resources. A comprehensive analysis of reported interventions is needed to better inform healthcare professionals about effective prevention. The aim of this systematic review and meta-analysis is to assess the effectiveness of interventions to prevent foot ulcers in persons with diabetes who are at risk thereof. Materials and Methods We searched the available scientific literature in PubMed, EMBASE, CINAHL, Cochrane databases and trial registries for original research studies on preventative interventions. Both controlled and non-controlled studies were eligible for …


Antioxidant Properties Of Kombucha Beverage Infused With Ganoderma Lucidum And Green Tea From Camellia Sinensis (L.) Kuntze With Several Fermentation Times, Rizki Rabeca Elfirta, Pamungkas Rizki Ferdian, Iwan Saskiawan, Tri Hadi Handayani, Kayla Faza Gustafri Mandalika, Rini Riffiani, Kasirah Kasirah, Ukhradiya Magharaniq Safira Purwanto Feb 2024

Antioxidant Properties Of Kombucha Beverage Infused With Ganoderma Lucidum And Green Tea From Camellia Sinensis (L.) Kuntze With Several Fermentation Times, Rizki Rabeca Elfirta, Pamungkas Rizki Ferdian, Iwan Saskiawan, Tri Hadi Handayani, Kayla Faza Gustafri Mandalika, Rini Riffiani, Kasirah Kasirah, Ukhradiya Magharaniq Safira Purwanto

Karbala International Journal of Modern Science

Kombucha is a functional beverage produced through the fermentation of infused tea or Camelia sinensis (L.) Kuntze (CS) by a symbiotic culture of bacteria and yeast. Apparently, the substrate of kombucha can be substituted to enhance its functional properties. Ganoderma lucidum (GL) is a potential substrate reported to have health benefits. This study aims to evaluate antioxidant properties by comparing different formulations and fermentation times. The formulations prepared in the present study varied in the compositions of GL and CS substrates, namely F1 (100% GL), F2 (75% GL: 25% CS), F3 (50% GL: 50% CS), F4 (25% GL: 75% CS), …


Overview Of The Zoonotic Potential And Coinfection Of Sars-Cov-2 In Indonesia, Muhammad Khaliim Jati Kusala, Ni Luh Putu Indi Dharmayanti Feb 2024

Overview Of The Zoonotic Potential And Coinfection Of Sars-Cov-2 In Indonesia, Muhammad Khaliim Jati Kusala, Ni Luh Putu Indi Dharmayanti

Karbala International Journal of Modern Science

In the ASEAN region, Indonesia has the highest overall COVID-19 infection score. The SARS-CoV-2 pandemic first emerged in China and then transmitted sporadically throughout the world. Animals and humans can be infected with the corona virus, so this disease is classified as a zoonotic disease. This review aims to gather information regarding the potential of SARS-CoV-2 as a zoonotic disease and coinfections with several other pathogens in Indonesia. This study collected data demonstrating the potential for COVID-19 to be transmitted from humans to animals, as an evidenced by positive test results for the Bat Coronavirus Antigen in bats. Cats have …


Assessment Of Professional Counseling Dispositions: A Content Validity Analysis, Patrick R. Mullen, Jacob Joseph, Kaitlin Jones Hinchey, Morgan Walker, Jennifer Niles Feb 2024

Assessment Of Professional Counseling Dispositions: A Content Validity Analysis, Patrick R. Mullen, Jacob Joseph, Kaitlin Jones Hinchey, Morgan Walker, Jennifer Niles

Teaching and Supervision in Counseling

Counselor educators evaluate the professional counseling dispositions of trainees throughout their development within training programs. There have been few consistent articulations of professional dispositions as many programs and measures define them differently. In our study, we developed the Assessment of Professional Counseling Dispositions (APCD) and performed a content validity study of the measure. Our findings provide evidence for the content validity of the APCD. We discuss these findings, their implications, and future research using the measure.


Counselor Trainee Cognitive Complexity: Peer Interactions And Assessments, Alexandra Gantt-Howrey, Erin Woods, Gulsah Kemer Feb 2024

Counselor Trainee Cognitive Complexity: Peer Interactions And Assessments, Alexandra Gantt-Howrey, Erin Woods, Gulsah Kemer

Teaching and Supervision in Counseling

In their training efforts, counselor educators focus on a variety of characteristics, including cognitive complexity (CC). Cognitively complex counselors can identify and integrate the multiple characteristics and perspectives of their clients and have been found to be generally more empathic and accepting of ambiguity (Castillo 2018; Granello, 2010; Welfare & Borders, 2010b). Although CC is considered as an integral counselor attribute (Castillo, 2018), how CC may be related to within-program peer interactions has yet to be explored. Through this convergent mixed methods study (Creswell & Creswell, 2017), we sought to understand how n = 7 participants’ experiences with and assessments …


Promoting Counselor Trainees’ Clinical Skill Development Using Virtual Reality Simulations, Amber L. Pope, Chelsea Hilliard Feb 2024

Promoting Counselor Trainees’ Clinical Skill Development Using Virtual Reality Simulations, Amber L. Pope, Chelsea Hilliard

Teaching and Supervision in Counseling

Although research on virtual reality (VR) as a pedagogical tool within counselor education is scarce, the parallel use of VR in health sciences education indicates VR simulations may have similar utility and effectiveness in training counselors. This conceptual piece aims to assist counselor educators in building VR simulations for counselors-in-training (CITs). The authors review the research on VR usage in counselor education and explore the practical implications of VR simulations for training counselors. The authors describe the development and utilization of VR simulations across multiple stages of training in a counselor education master’s program to support CITs’ clinical skill development …


The Class Of 2019: Academic Employment Prospects For Counselor Education Doctoral Graduates, Christopher Lawrence, Gregory Hatchett Feb 2024

The Class Of 2019: Academic Employment Prospects For Counselor Education Doctoral Graduates, Christopher Lawrence, Gregory Hatchett

Teaching and Supervision in Counseling

The purpose of this investigation was to estimate the percentage of counselor education doctoral (CED) program graduates who attained faculty positions within two years of graduation and to compare the number of these graduates to the number of advertised faculty positions during this same timeframe. To do so, we used archival, publicly available data for graduates of CACREP-accredited CED programs during the 2018-2019 academic cycle (N = 314). Approximately two-fifths of these graduates had faculty positions. Graduation from a public university increased the odds of having any faculty post, whereas graduation from a public university and the Carnegie Classification of …


A Model Of Retention And Remediation For Online Counselor Education, Colleen M. Grunhaus, Matthew Lyons Feb 2024

A Model Of Retention And Remediation For Online Counselor Education, Colleen M. Grunhaus, Matthew Lyons

Teaching and Supervision in Counseling

Online counseling programs experience unique retention and gatekeeping challenges. Increased isolation and personal adversities are common factors associated with attrition for online students; and broad-access admission policies of online counseling programs often lead to increased gatekeeping concerns postadmission. Counseling programs develop policies and procedures related to retention, remediation, and dismissal, but extant models of remediation do not also address student retention or the unique challenges of online counselor education. We present a model, The Retention and Remediation Model for Online Counselor Education, that demonstrates a comprehensive policy for retention, remediation, and dismissal in online counseling programs through a three-prong approach …


Perceptions Of The Instructional Research Training Environment And Research Self-Efficacy, Missy Moore, John Mccall, Todd Bolin, Austen Bingham Feb 2024

Perceptions Of The Instructional Research Training Environment And Research Self-Efficacy, Missy Moore, John Mccall, Todd Bolin, Austen Bingham

Teaching and Supervision in Counseling

We examined counselor education and supervision (CES) doctoral students’ (n = 117) perceptions of their instructional RTE and research self-efficacy. Students had more positive perceptions of their instructional RTE and higher research self-efficacy when research courses were taught by counseling faculty. Additionally, the instructional RTE was predictive of research self-efficacy above and beyond intrapersonal, interpersonal, and experiential variables. Implications for counselor education programs are provided.


Professional Identity Development Of Black Doctoral Students In Counselor Education: A Reflexive Model, Olivia T. Ngadjui Phd, Elizabeth A. Doughty Horn Feb 2024

Professional Identity Development Of Black Doctoral Students In Counselor Education: A Reflexive Model, Olivia T. Ngadjui Phd, Elizabeth A. Doughty Horn

Teaching and Supervision in Counseling

This grounded theory study comprised the perspectives of how past and current Black doctoral students formalized their professional identity in counselor education. Findings included reflexivity as a central theme within the internal process of Black doctoral students navigating counselor education programs and a model of professional identity development.


Relationships Of Empathy And Color-Blind Attitudes On Counseling Students’ Critical Consciousness, Bagmi Das, Maggie M. Parker, Sarah Litt Feb 2024

Relationships Of Empathy And Color-Blind Attitudes On Counseling Students’ Critical Consciousness, Bagmi Das, Maggie M. Parker, Sarah Litt

Teaching and Supervision in Counseling

A critical piece of counselor education is enhancing counselors’ in training (CITs) multicultural competence. Concepts included in CIT cultural development include both developing empathy (Constantine, 2001) and dismantling color-blind racial attitudes` (Neville et al., 2013). Thus, this study presents multiple regression to explore the relationships between color blindness, empathy development, and critical consciousness of 166 counseling students. Results indicate that that empathy and color-blind attitudes have associations with some aspects of critical consciousness, but not sociopolitical participation. Implications for counselor education and directions for future research are discussed.