Digital Commons Network^™

Genome Editing Using Crispr-Cas9 In Annual Killifish Species, Keria Moritsugu-Vandehey

University Honors Theses

CRISPR-Cas9 genome editing has been used successfully to knock out genes in model organisms such as zebrafish, turquoise killifish, and cichlid fish. CRISPR-Cas9 genome editing has not been verified in the annual killifish, Austrofundulus limnaeus. We hypothesize that targeted editing of the tyrosinase gene in embryos of A. limnaeus will lead to fish without the ability to produce black pigment. Embryos at the 1-cell stage were injected with a Cas9 cocktail containing a mix of guide RNA molecules that target the genomic sequence of the tyrosinase gene and either an mRNA coding for the Cas9 protein or Cas9 protein. …

Psilocybin With Acceptance And Commitment Therapy (Act) For The Treatment Of Social Anxiety Disorder (Sad), Aspen E. Allred

University Honors Theses

Social Anxiety Disorder (SAD) is a debilitating mental health condition characterized by an overwhelming fear and anxiety of social rejection that can lead to chronic patterns of social behavioral avoidance. Despite the existence of traditional efficacious treatments, a significant number of individuals either do not respond to treatment or experience a recurrence of symptoms over extended periods, spanning 10-12 years. Acceptance and Commitment Therapy (ACT), a form of acceptance-based behavioral therapy considered part of the "third wave" of cognitive behavioral therapies, has shown promising results in early studies, comparable to those of Cognitive Behavioral Therapy (CBT) that is considered the …

Supply Is Not Limulus: Research Review Of Horseshoe Crab Conservation In The Face Of Intense Pharmaceutical Demand, Zoya Galeev

University Honors Theses

Horseshoe crabs are being used by the pharmaceutical industry to conduct endotoxin tests using LAL derived from the organism’s blood to ensure safe medical practice. Their annual collection and bleeding, while not always leading to mortality, affects horseshoe crab behavior and health. This research seeks to understand how the American horseshoe crab, L. polyphemus, is being used by pharmaceutical agencies and the implications that their harvesting has on the industry and the conservation of the species. Studies were collected from the past decade across two databases, Web of Science (WOS) and PubMed, to assess present conservation techniques to reduce …

Providing Incarcerated Youth With A Community Of Their Peers, Providing Resources, And Modeling Healthy Attachment May Lead To Prosocial Behaviors, Emilee Brnusak

University Honors Theses

This thesis examines the connection between gang activity and attachment style. A summary of literature suggests that childhood attachment injuries lead to antisocial, maladaptive relationships and neurological changes that impact executive functioning and emotional regulation. These factors leave youth at higher risk of gang membership. This thesis then explores how an outreach experience at the MacLaren Youth Correctional Facility inspired a large-scale intervention called Resources for Attachment-injured Youth (RAY) that could be implemented in youth prisons across the country.

What Explains Male And Female Decision Making To Enter Law? Evidence From A Survey Of Us-Based Undergraduate Students, Abigail Cohen

University Honors Theses

The research conducted in this thesis aims to explain why fewer females than males choose law and pinpoint the explanation as to why they have disparate experiences in the field. The hypothesis is sex discrimination is to blame for the differences among female and male decision making. Sexual harassment and discrimination plays a very prominent role in male dominated fields and discourages females from joining those workforces. The research method for this experiment was an anonymous survey, sent out via social media and email. The survey method was chosen because it was meant to be a quick, yet effective way …

Primary Care As A Protective Factor: A Vision To Transform Health Care Delivery And Overcome Disparities In Health, Edward L. Machtinger, Alicia F. Lieberman, Christina D. Bethell, Marguerita Lightfoot

OHSU-PSU School of Public Health Faculty Publications and Presentations

A large body of research demonstrates that experiences of trauma, especially when they occur in the absence of safe, stable, nurturing relationships (SSNRs) and environments— known as protective factors— interrupt healthy development and predispose both children and adults to the most common causes of physical and mental illness and early death.1,2 Because minoritized and low-income populations are exposed to more trauma and have access to fewer protective factors, they experience higher rates of trauma-related health and social problems and severe disparities in health.1–4 Primary care clinicians increasingly recognize the role that trauma plays in the health and well-being of their …

Patient And Caregiver Perspectives On Implementation Of Ace Screening In Pediatric Care Settings: A Qualitative Evaluation, Ingrid Estrada-Darley, Peggy Chen, Ryan Mcbain, Gabriela Alvarado, Charles Engel, Nipher Mallika, Edward L. Machtinger, Brigid Mccaw, Marguerita Lightfoot, Multiple Additional Athors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction

This qualitative research study explored the perspectives of adolescents, 12 to 19-years-old, and caregivers of children under 12-years-old on the acceptibility of adverse childhood experiences (ACEs) screenings in five pediatric clinics.

Method

A constructivist grounded theory approach was utilized. One-on-one semistructured phone interviews were conducted with 44 adolescents and 95 caregivers of children less than 12 years old. Interviews were analyzed using thematic analysis.

Results

Most participants reported feeling comfortable discussing ACEs with their providers. Some reported that screening helped build trust. Others expressed privacy concerns and did not receive information about the reason for screening. Adolescent patients …

Effect Of Company-Driven Disability Diversity Initiatives: A Multi-Case Study Across Industries, Brian N. Phillips, Teresa A. Granger, Chase Ochrach, Kathryn A. Thomas, Antonio Reyes, Rachel F. Kesselmayer, Catherine A. Anderson, Katherine B. Friedman, Multiple Additional Authors

Counselor Education Faculty Publications and Presentations

OBJECTIVE: In this article, we share insights emerging from case studies conducted across seven companies.We illustrate the motives, processes, and outcomes of these initiatives. METHODS: This study is built on the previously published case studies conducted across seven companies. We applied elements of consensual qualitative research (CQR) for the data collection and analyses before performing an in-depth qualitative content analysis using the data coded for each company, looking for commonalities and differences. RESULTS: Although practices differed, all companies experienced noted benefits. Committed leadership and complementary company values facilitated successful outcomes for initiatives. The strength or salience of disability-inclusive actions and …

Racialization, Individualism, And Denial: How The American And Australian Dreams Uphold The Homelessness And Poverty Crises Of Today, Emily Rose Andrews

Social Sciences

Inspired by my lived experience of immersion in the Tenderloin neighborhood of San Francisco, California, for two weeks; studying abroad in Adelaide, South Australia, for two months; and my current internship at the Department of Social Services in San Luis Obispo, California, I plan on formulating a research paper on the topic of homelessness for my senior project. Specifically, through an extensive literature review and analysis, I will investigate: How does the culture of poverty ideology influence public opinions and policy responses to homelessness in the United States and Australia? To answer this question, I will first introduce the concept …

The Impact Of Social Pressure On High-Income Working Mothers In Academia, Emily Pokorski, Ranelle Brew, Tess Scheidel

Open Access Publishing Support Funded Articles

Working mothers are often displayed as superheroes for all that they manage by taking on roles like mother, professional, and homemaker, which leaves them feeling burnout. The purpose of this study is to explain social pressures impacting working mothers, who is inflicting social pressures, and what areas of their life are being impacted. Additionally, it investigates how the pandemic has changed the work-life balance and where they are spending their time. Researchers used an online Qualtrics survey to collect data from two social media platforms. A total of 272 participants filled out the questionnaire and were eligible for the study. …

Face Peace Design Brief #3: Facilitating Training And Education Programs In The Peacebuilding Field, John Porten

Kroc IPJ Research and Resources

Trust-building and social bonding are easier in person — and to some extent in synchronous rather than asynchronous distanced learning. Distance and time differences can make organization of synchronous learning difficult. Differences in access to the internet and other infrastructure issues can exacerbate this problem. Cultural differences and other forms of diversity can also make building trust among students, and between students and teachers, more difficult.

While advances in technology and technique have improved the outcomes of distanced educational programs in recent years, distanced educational models still result in underperformance for the participants when compared to face-to-face programs. Research shows …

Face Peace Design Brief #4: Negotiation And Consensus Building In Hybrid Environments, John Porten

Kroc IPJ Research and Resources

This FACE Peace Design Brief considers negotiation and consensus-building programs using a mix of in-person and distanced elements. Recent advances in technology and cultural shifts brought about by the COVID-19 pandemic have allowed program and event designers to consider a wide variety of tools and practices that allow negotiations and bargaining to happen at a distance or asynchronously.

The Role Of Team Identification And Self-Construal On Attitudes Toward Player Resting, Skyler King, Ismail Karabas

Faculty & Staff Research and Creative Activity

Purposely resting athletes during competitive games has become commonplace in the National Basketball Association (NBA). Despite this phenomenon, little research has investigated fan attitudes and behavioral intentions concerning the act of NBA teams purposely resting players. This study utilized Prolific Academic crowdsourcing service to recruit a national sample of NBA fans to participate in this research. Participants provided data concerning their attitudes toward the practice of player resting as well as their strength of team identification and self-construal level. Results indicate that those who are low on both team identification and an interdependent self-construal should be expected to respond negatively …

The Lead, Mid-Spring 2024, Lindenwood University

The Lead

The Lead is an electronic newsletter produced by the Lindenwood College of Education & Human Services.

Trans-Disciplinary Communication In Collaborative Co-Design For Knowledge Sharing, James Lipuma, Cristo León

STEM for Success Resources

Explore the transformative power of Trans-Disciplinary Communication in Collaborative Co-Design for effective knowledge sharing.

Rights
All content in this magazine is licensed under a Creative Commons Attribution License. Attribution-Non-Commercial-Non-Derivatives 4.0 International (CC BY-NC-ND 4.0).

Severe Stiff-Person Syndrome After Covid: The First Video-Documented Covid Exacerbation And Viral Implications, Marinos C. Dalakas

Department of Neurology Faculty Papers

OBJECTIVES: To describe a patient with mild GAD-positive stiff-leg syndrome (SLS) who developed severely disabling stiff-person syndrome (SPS) 1 week after mild COVID-19 and discuss the impact of viral implications.

METHODS: Video-documented serial clinical observations at baseline, after acute COVID-19, and after IVIG treatments.

RESULTS: A 39-year-old man with left-SLS was stable during a 2-year follow-up with low-dose antispasmodics, working fully and functioning normally, even able to run. One week after mild COVID-19, he started to experience generalized SPS symptomatology that steadily worsened the following 2-3 weeks, becoming unable to walk, requiring a walker, with significant thoracolumbar and bilateral leg …

Understanding Karai Kasang And Nats: A Basis For Dialogue With Kachin Traditional Religion And Spirituality, Than Naing Lin

Loyola Papers

This article investigates the theological foundations of Kachin traditional religion and its engagement with Christianity. Focusing on Karai Kasang as the Kachin understanding of the Creator, this paper evaluates early inculturation efforts that appropriated the term for the Christian God. It critically identifies both historical and ongoing limitations in these approaches. The study proposes a renewed dialogue grounded in discerning the activity of the Spirit within indigenous traditions, offering a pathway toward an authentically Asian pneumatology.

Full Issue, Volume 5, Issue 1

Loyola Papers

No abstract provided.

Optimization Of Factors Affecting The Performance Of A Fluidized Bed Dryer, Soner Celen, Sultan Pektas

The Philippine Agricultural Scientist

This study investigated the theoretical, analytical, and experimental effects of parameters such as bed height, air velocity, and air temperature on drying using a fluidized bed dryer. The objective was to examine how these parameters influence the drying process of salt products in a pilot fluidized bed dryer and establish the foundation for the development of a future full-scale machine. Salt products with an initial moisture content of 3% were used in all experimental trials. The pressure drop was determined by calculating the minimum fluidization rate, Archimedes and Reynolds number. The calculated values were compared with the analyses conducted using …

The Horrors Of Motherhood: An Examination Of Mothers In The Modern Horror Film, Abby Griffith

QuaesitUM

No abstract provided.

Rebuilding The Pyramid [Of Sound]: Shifting Ensemble Pedagogical Approaches, Olivia Remak

QuaesitUM

No abstract provided.

Analysis And Comparison Of Hybrid Gold-Based Nanoparticles And Their Potential Use In Optical Spectroscopy And Cancer Nanomedicine, Hailey Miller, Alberto Rodriguez

QuaesitUM

No abstract provided.

Agn Feedback In Galaxy Formation, Joseph Zeron

QuaesitUM

No abstract provided.

The Nontransitive Dice: New Results For A Statistical Paradox In A Game Of Chance, Noah Molder

QuaesitUM

No abstract provided.

National Trends Of Vascular Risk Factor Control Among Stroke Survivors: From The National Health And Nutrition Examination Survey 2009 To 2020, Hend Mansoor, Daniel Manion, Kara Jo Swafford, Gregory A. Jicha, Daniela Claudia Moga

Neurology Faculty Publications

BACKGROUND: Contemporary data describing the national trends on vascular risk factor control among stroke survivors are limited.

METHODS AND RESULTS: This is a cross-sectional analysis of the National Health and Nutrition Examination Survey cycles 2009 to 2010 to 2017 to March 2020. Adults (≥18 years of age) with a self-reported diagnosis of stroke were identified. Age- adjusted trends in hypertension, diabetes, and hyperlipidemia control were examined. Sex and racial differences in vascular risk factor control were also investigated. Among 32 497 adult individuals who participated in the National Health and Nutrition Examination Survey, 1354 participants (4.2%) self-reported a prior diagnosis …

From Emergency Rooms To Boardrooms, Tow Keang Lim

Asian Management Insights

How doctors think can improve business decision-making.

Smart Heuristics For Smart Management, Jochen Reb, Shenghua Luan, Gerd Gigerenzer

Asian Management Insights

How leaders can make effective decisions in a VUCA world.

Distributed Solar Generation: Current Knowledge And Future Trends, Gasser G. Ali, Islam H. El-Adaway

Civil Engineering Faculty Publications

Distributed solar generation (DSG) has been growing over the previous years because of its numerous advantages of being sustainable, flexible, reliable, and increasingly affordable. DSG is a broad and multidisciplinary research field because it relates to various fields in engineering, social sciences, economics, public policy, and others. Developing a holistic understanding of the state of research related to DSG can be difficult. Motivated to provide that understanding, the goal of this paper is to explore current and emerging multidisciplinary research trends associated with DSG. To achieve that, (1) a large data set of approximately 66,000 publications was collected; (2) the …

Inverting Geodetic Strain Rates For Slip Deficit Rate In Complex Deforming Zones: An Application To The New Zealand Plate Boundary, Kaj M. Johnson, Laura M. Wallace, Jeremy Maurer, Ian Hamling, Charles Williams, Chris Rollins, Matt Gerstenberger, Russ Van Dissen

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The potential for future earthquakes on faults is often inferred from inversions of geodetically derived surface velocities for locking on faults using kinematic models such as block models. This can be challenging in complex deforming zones with many closely spaced faults or where deformation is not readily described with block motions. Furthermore, surface strain rates are more directly related to coupling on faults than surface velocities. We present a methodology for estimating slip deficit rate directly from strain rate and apply it to New Zealand for the purpose of incorporating geodetic data in the 2022 revision of the New Zealand …

A Priori Procedure To Establish Spinodal Decomposition In Alloys, Simon Divilov, Hagen Eckert, Cormac Toher, Rico Friedrich, Adam C. Zettel, Donald W. Brenner, William G. Fahrenholtz, Douglas E. Wolfe, Eva Zurek, Jon Paul Maria, Nico Hotz, Xiomara Campilongo, Stefano Curtarolo

Materials Science and Engineering Faculty Research & Creative Works

Spinodal decomposition can improve a number of essential properties in materials, especially hardness. Yet, the theoretical prediction of the onset of this phenomenon (e.g., temperature) and its microstructure (e.g., wavelength) often requires input parameters coming from costly and time-consuming experimental efforts, hindering rational materials optimization. Here, we present a procedure where such parameters are not derived from experiments. First, we calculate the spinodal temperature by modeling nucleation in the solid solution while approaching the spinode boundary. Then, we compute the spinodal wavelength self-consistently using a few reasonable approximations. Our results show remarkable agreement with experiments and, for NiRh, the calculated …