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Articles 167491 - 167520 of 1738632
Full-Text Articles in Entire DC Network
Conformal-Projective Transformations On Statistical And Semi-Weyl Manifolds With Torsion, Adara M. Blaga, Antonella Nannicini
Conformal-Projective Transformations On Statistical And Semi-Weyl Manifolds With Torsion, Adara M. Blaga, Antonella Nannicini
Turkish Journal of Mathematics
We show that statistical and semi-Weyl structures with torsion are invariant under conformal-projective transformations. We prove that a nondegenerate submanifold of a semi-Weyl (respectively, statistical) manifold with torsion is also a semi-Weyl (respectively, statistical) manifold with torsion, and that the induced structures of two conformal-projective equivalent semi-Weyl (respectively, statistical) structures with torsion on a manifold to a nondegenerate submanifold, are conformal-projective equivalent, too. Also, we prove that the umbilical points of a nondegenerate hypersurface in a semi-Weyl manifold with torsion are preserved by conformal-projective changes. Then we consider lightlike hypersurfaces of semi-Weyl manifolds with torsion and we describe similarities and …
Warped Product Pointwise Hemislant Submanifolds Whose Ambient Spaces Arenearly Para-Kaehler Manifolds, Sedat Ayaz, Yilmaz Gündüzalp
Warped Product Pointwise Hemislant Submanifolds Whose Ambient Spaces Arenearly Para-Kaehler Manifolds, Sedat Ayaz, Yilmaz Gündüzalp
Turkish Journal of Mathematics
In this article, we explain pointwise slant, pointwise hemislant, and warped product pointwise hemislant submanifolds whose ambient spaces are nearly para-Kaehler manifolds. Also, we obtain several theorems and examples. Subsequently, we get some results concerning the inequality.
Existence And Uniqueness Of Continuous Solutions For Iterative Functional Differential Equations In Banach Algebras, Khaled Ben Amara
Existence And Uniqueness Of Continuous Solutions For Iterative Functional Differential Equations In Banach Algebras, Khaled Ben Amara
Turkish Journal of Mathematics
This paper is devoted to studying the existence and uniqueness of continuous solutions of the following iterative functional differential equation d dt x(t) − h ( t, x[1](t), . . . , x[n](t) ) f (t, x[1](t), . . . , x[n](t)) = g ( t, x[1](t), . . . , x[n](t) ) , t ∈ J, x(0) = x0. By using of Boyd-Wong’s fixed point theorem and under suitable conditions, we establish the existence and uniqueness of a continuous solution.
Resilience To Supply Chain Disruptions: An Investigation Of The Roles Of Innovativeness And Green Supply Chain Management Practices During The Covid-19 Pandemic, Lindsay Givens
Graduate Theses and Dissertations (2019 - present)
The number of global supply chain disruptions is increasing at an alarming rate. These disruptions vary in terms of source, duration, and scope, but all pose major threats to the continuity of firms worldwide. Because of this increase in turbulence, there has been heightened interest in recent years surrounding the development of firm-level resilience to such disruptions. The supply chain sustainability research stream is relatively well-developed; less is known, however, about specific strategies for strengthening resilience. This study aims to contribute to the resilience literature by examining the viability of innovativeness and the adoption of green supply chain management practices …
Multi-Script Handwriting Identification By Fragmenting Strokes, Joshua Jude Thomas
Multi-Script Handwriting Identification By Fragmenting Strokes, Joshua Jude Thomas
Graduate Theses and Dissertations (2019 - present)
This study tests the effectiveness of Multi-Script Handwriting Identification after simplifying character strokes, by segmenting them into sub-parts. Character simplification is performed through splitting the character by branching-points and end-points, a process called stroke fragmentation in this study. The resulting sub-parts of the character are called stroke fragments and are evaluated individually to identify the writer. This process shares similarities with the concept of stroke decomposition in Optical Character Recognition which attempts to recognize characters through the writing strokes that make them up. The main idea of this study is that the characters of different writing‑scripts (English, Chinese, etc.) may …
Flood Waters Rise: Hurricanes, Disaster Response, And Race Relations In Coastal Alabama, 1906 – 2006, Danielle Leonardi
Flood Waters Rise: Hurricanes, Disaster Response, And Race Relations In Coastal Alabama, 1906 – 2006, Danielle Leonardi
Graduate Theses and Dissertations (2019 - present)
This thesis examines the changes in social relations after natural disasters, specifically hurricanes. The Hurricane of 1906 caused massive damage to Mobile due to the limited warnings. Tensions before the hurricane were already heightened from the Atlanta Race Riot and boiled over after the storm, resulting in a double lynching. Mobile received very little federal aid after the 1906 hurricane and relief heavily on their own communities and the Alabama National Guard. Hurricane Frederic in 1979 was much different because of its position in the Civil Rights Movement. The government relief was slow due to the overwhelming amount needed, and …
Examining Outcomes Of Privacy Risk And Brand Trust On The Adoption Of Consumer Smart Devices, Marianne C. Loes
Examining Outcomes Of Privacy Risk And Brand Trust On The Adoption Of Consumer Smart Devices, Marianne C. Loes
Graduate Theses and Dissertations (2019 - present)
With more connected devices on earth than there are people, Internet of Things (IoT) is arguably just as innovative as the original introduction of the Internet. Though much of the research on technology acceptance and adoption has been conducted in organizational settings, the consumer use of IoT technologies, such as smart devices, is becoming a fertile field of research. The merger of these research streams is especially relevant from a societal perspective as smart devices become more embedded in consumer’s daily lives, particularly with the introduction of the “meta verse.” While original technology acceptance research is limited to two system-specific …
Breaking Barriers: An Innovative Tool To Assess The National And City-Level Physical Activity Policy Development To Practice Disconnect, Eugen Resendiz, Andrea Ramírez-Varela, Juliana Mejía-Grueso, Jane Moon, Josef Mitáš, Ross C Brownson, Deborah Salvo, Michael Pratt
Breaking Barriers: An Innovative Tool To Assess The National And City-Level Physical Activity Policy Development To Practice Disconnect, Eugen Resendiz, Andrea Ramírez-Varela, Juliana Mejía-Grueso, Jane Moon, Josef Mitáš, Ross C Brownson, Deborah Salvo, Michael Pratt
Faculty, Staff and Student Publications
Background: Population-level physical activity increases are improbable without intersectoral collaboration across government levels and sectors to develop and implement physical activity promotion policies. This study aims to provide information about the development of the Interaction between National and Local Government Levels in Development and Implementation of Physical Activity Policies Tool (INTEGRATE PA-Pol). A framework was created to examine the development and implementation of national and subnational physical activity policies and the (mis)alignment between government levels.
Methods: The work was conducted in 3 phases: (1) a scoping review was carried out to identify local government physical activity promotion policies and instruments …
Ictal Central Apnea Is Predictive Of Mesial Temporal Seizure Onset: An Intracranial Investigation, Nuria Lacuey, Blanca Talavera, Oman Magana-Tellez, Oscar Mancera-Páez, Norma Hupp, Xi Luo, Johnson P Hampson, Jaison Hampson, M R Sandhya Rani, Manuela Ochoa-Urrea, Omar A Alamoudi, Stephen Melius, Sandipan Pati, Jay Gavvala, Nitin Tandon, John C Mosher, Samden D Lhatoo
Ictal Central Apnea Is Predictive Of Mesial Temporal Seizure Onset: An Intracranial Investigation, Nuria Lacuey, Blanca Talavera, Oman Magana-Tellez, Oscar Mancera-Páez, Norma Hupp, Xi Luo, Johnson P Hampson, Jaison Hampson, M R Sandhya Rani, Manuela Ochoa-Urrea, Omar A Alamoudi, Stephen Melius, Sandipan Pati, Jay Gavvala, Nitin Tandon, John C Mosher, Samden D Lhatoo
Faculty, Staff and Student Publications
Objective: Ictal central apnea (ICA) is a semiological sign of focal epilepsy, associated with temporal and frontal lobe seizures. In this study, using qualitative and quantitative approaches, we aimed to assess the localizational value of ICA. We also aimed to compare ICA clinical utility in relation to other seizure semiological features of focal epilepsy.
Methods: We analyzed seizures in patients with medically refractory focal epilepsy undergoing intracranial stereotactic electroencephalographic (SEEG) evaluations with simultaneous multimodal cardiorespiratory monitoring. A total of 179 seizures in 72 patients with reliable artifact-free respiratory signal were analyzed.
Results: ICA was seen in 55 of 179 (30.7%) …
Phase Ib/Ii Study Of Lacnotuzumab In Combination With Spartalizumab In Patients With Advanced Malignancies, Jibran Ahmed, Bettzy Stephen, Yali Yang, Evan Kwiatkowski, Chinenye Lynette Ejezie, Shubham Pant
Phase Ib/Ii Study Of Lacnotuzumab In Combination With Spartalizumab In Patients With Advanced Malignancies, Jibran Ahmed, Bettzy Stephen, Yali Yang, Evan Kwiatkowski, Chinenye Lynette Ejezie, Shubham Pant
Faculty, Staff and Student Publications
INTRODUCTION: Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resistance to this blockade. Combining spartalizumab (PDR001), a high-affinity, ligand-blocking, humanized anti-PD-1 immunoglobulin G4 antibody, with lacnotuzumab (MCS110), a high-affinity, humanized monoclonal antibody directed against human CSF-1 can potentially overcome this resistance.
METHODS: This was a multicenter, phase Ib/II trial using a combination of spartalizumab with lacnotuzumab in patients with advanced cancers, including anti-PD-1/PD-L1 treatment-resistant melanoma, and anti-PD-1/PD-L1 treatment-naïve triple-negative breast cancer, pancreatic cancer, and endometrial cancer (ClinicalTrials.gov identifier: NCT02807844). The …
A Precious Gift: A Reflection And Resource On Water Quality And Sustainability, Mark Potosnak, Andrew Panelli, Adrienne Kalmes, Antonio Quintanilla, Dr. George Nassos, Michael Terrien, Obl. Osb
A Precious Gift: A Reflection And Resource On Water Quality And Sustainability, Mark Potosnak, Andrew Panelli, Adrienne Kalmes, Antonio Quintanilla, Dr. George Nassos, Michael Terrien, Obl. Osb
College of Science and Health Faculty and Staff Works
This reflection, prepared by Illinois Catholics concerned with the intersection of faith, environmental stewardship, and social justice, explores the theological, moral, and practical dimensions of water quality and sustainability in the state. Rooted in Scripture, and Catholic liturgy and tradition, it affirms water as a sacred gift, essential for life and a universal human right. Drawing on Catholic social teaching and Pope Francis’ Encyclical Laudato Si’: On Care for Our Common Home, it examines pressing water challenges in Illinois, including contamination from coal ash, nitrates, PFAS, and lead, as well as infrastructure, affordability, and sustainability concerns. The document offers an …
Complete Issue, Patrick J. O'Connor Phd, Laura Owen, Moya Malcolm, Diana Camilo, Christopher W. Tremblay
Complete Issue, Patrick J. O'Connor Phd, Laura Owen, Moya Malcolm, Diana Camilo, Christopher W. Tremblay
Journal of College Access
No abstract provided.
Introductory Pages, Christopher W. Tremblay, Patrick J. O'Connor Phd, Diana Camilo, Laura Owen, Moya Malcolm
Introductory Pages, Christopher W. Tremblay, Patrick J. O'Connor Phd, Diana Camilo, Laura Owen, Moya Malcolm
Journal of College Access
No abstract provided.
Moving Beyond Transactions: Understanding The Relationships Between College Access Professionals And Underrepresented College-Bound Families, Stephany Cuevas
Moving Beyond Transactions: Understanding The Relationships Between College Access Professionals And Underrepresented College-Bound Families, Stephany Cuevas
Journal of College Access
Framed by family engagement frameworks, this study presents four types of interactions college access professionals (CAPs) have with the families of underrepresented college-going students—inconsistent communication, transactional exchanges, student-family mediation, and trusting relationships—to explore the nature of family-educator partnerships for students’ college access. Drawing from in-depth qualitative interviews with a diverse sample of 20 CAPs, this study demonstrates that the nature of these interactions and their corresponding family engagement practices are influenced by CAPs’ job requirements and previous experiences working with families. This ultimately shapes their ability to invest in and develop strong, trusting partnerships with students’ families. By understanding these …
Master Narrative Of College Access Belies Reality For Today’S Students, Jonathan S. Lewis, René A. Hernandez
Master Narrative Of College Access Belies Reality For Today’S Students, Jonathan S. Lewis, René A. Hernandez
Journal of College Access
Master and alternative narratives offer a useful framework through which to consider contemporary issues in college access. Implicit and ubiquitous, the master narrative of a linear progression from high school through a residential college toward a fulfilling career has long been dominant. Meanwhile, alternative narratives of fluid, dynamic, alternate pathways are ascendant, having received a boost from the Covid-19 pandemic and the stubborn lack of affordable postsecondary options. Observing a decline in a shared cultural narrative about college, the authors recommend that advisors help students to sort through possible storylines and then write their own.
Utilizing Electrical Geophysical Methods To Map Mycorrhizal Mycelium Networks Non-Invasively, Donald Pesonen
Utilizing Electrical Geophysical Methods To Map Mycorrhizal Mycelium Networks Non-Invasively, Donald Pesonen
Graduate Dissertations and Theses
Mycorrhizal mycelium networks are a key component to forest health. These networks act as a transportation system for nutrients, are major players in carbon and nitrogen cycling, and can provide some level of drought resistance to the surrounding flora. Due to the location and size of these network’s filaments, studying mycelium non-invasively has been difficult. The alternative method of laboratory grown samples, lacks the important environmental factors that play into the growth and development of mycelium. Mycelium’s inherent conductivity and moisture retention allows for these networks to be a viable target for electrical geophysical equipment. CMD-Tiny, a small shallow depth …
Project Foresight Annual Report, 2022-2023, Paul Speaker
Project Foresight Annual Report, 2022-2023, Paul Speaker
Faculty & Staff Scholarship
Project FORESIGHT is a business-guided self-evaluation of forensic science laboratories across the globe. The participating laboratories represent local, regional, state, and national agencies. Economics, accounting, finance, and forensic faculty provide assistance, guidance, and analysis. Laboratories participating in Project FORESIGHT have developed standardized definitions for metrics to evaluate work processes, linking financial information to work tasks, and functions. Laboratory managers can then assess resource allocations, efficiencies, and value of services—the mission of Project FORESIGHT is to measure, preserve what works, and change what does not.
The benchmark data for the 2022-2023 performance period includes laboratory submissions for a variety of fiscal …
Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin
Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin
Chemical Engineering Undergraduate Honors Theses
Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.
Biological sex is an important factor for cardiac health and …
An Examination Of Products That University Of Mississippi Students Consume For Managing Their Stress, Kiersten Rickard
An Examination Of Products That University Of Mississippi Students Consume For Managing Their Stress, Kiersten Rickard
Honors Theses
Students are notoriously one of the most stressed groups in our society. Stress is a complex topic; causes, mitigation methods, and manifestations of stress all vary in an individual. Being that stress is an universal experience, this research capitalizes on the importance of stress and the methods used to mitigate stress. This study looks at, among other ideas, stress on the University of Mississippi campus in regards to demographics and the products (caffeine, sleep aids, over the counter medicines, stress supplements, and CBD) that students use. Results demonstrate that, overall, higher stress levels correlate to higher product usage rates. The …
The Impact Of The 2002 Economic Crisis On Remittances & Emigration In Uruguay, Abigail Robeson
The Impact Of The 2002 Economic Crisis On Remittances & Emigration In Uruguay, Abigail Robeson
Honors Theses
Throughout 2002, the Uruguayan peso depreciated by 85 percent, causing an economic crisis and a rise in people searching outward for employment. This increased both the number of remittances received and emigration in an unprecedented way within Uruguay. Reports of remittances, and migration patterns of Uruguayans before 2002 are vastly different from those of the years following. Using quantitative analysis and a variety of data sources, this paper finds that the Uruguayan economic crisis undoubtedly spurred both remittance relevance and emigration in Uruguay. Emigration and remittances concerning Uruguay are seen to be permanently impacted by the crisis – though to …
Examining The Shared Decision-Making Preferences Of Adult Black Men With Hypertension In The U.S. Mid-South Region: A Mixed Methods Approach, Samantha Faith Calhoun
Examining The Shared Decision-Making Preferences Of Adult Black Men With Hypertension In The U.S. Mid-South Region: A Mixed Methods Approach, Samantha Faith Calhoun
Theses and Dissertations (ETD)
Purpose. This study aimed to explore what factors are related to Black men’s shared decision-making (SDM) preferences for selecting hypertension (HTN) treatment and management options with a healthcare clinician. Methods. Researchers employed an exploratory sequential mixed methods design to explore factors influencing Black adult men's preferences for involvement in SDM regarding HTN treatment. Qualitative interviews with N=16 Black men identified factors related to SDM involvement, while a quantitative phase with N=105 Black men examined factors that could predict the level of involvement in SDM for HTN treatment. Results. Trust and having a female clinician were a significant independent predictor of …
Identifying Contributors To Acute Stroke Transfer Delays From Lower To Higher Level Stroke Centers, Jennifer Patterson
Identifying Contributors To Acute Stroke Transfer Delays From Lower To Higher Level Stroke Centers, Jennifer Patterson
Theses and Dissertations (ETD)
The intricate process of efficiently transferring patients within the healthcare setting has proven to be complex however, it is a critical component to ensure timely access to essential medical interventions. Navigating these complexities presents a multifaceted challenge that is not fully understood. For patients suffering a stroke, these transfer delays may render them ineligible for treatment and left with disabling disability. This collective work aims to identify contributors to delays in transfer from lower to higher levels of care in the acute stroke populations.
Three papers emerged from this thesis. First, a narrative review of the literature published between January …
Barriers To Mental Health Treatment Among Medical Students: Preclinical Vs. Clinical Years, Urvashi Singh, Agnes Wrobel
Barriers To Mental Health Treatment Among Medical Students: Preclinical Vs. Clinical Years, Urvashi Singh, Agnes Wrobel
Posters
Our study aims to:
- Investigate medical students’ attitudes towards seeking assistance from mental health professionals.
- Compare the importance of various barriers that deter help-seeking in preclinical vs. clinical years of medical education.
Clinical Differences In Isolated Post-Capillary Pulmonary Hypertension And Combined Pre- And Postcapillary Pulmonary Hypertension, Emily Schneider, Bhavinkumar D. Dalal
Clinical Differences In Isolated Post-Capillary Pulmonary Hypertension And Combined Pre- And Postcapillary Pulmonary Hypertension, Emily Schneider, Bhavinkumar D. Dalal
Posters
PULMONARY HYPERTENSION (PH) = RESTING MEAN PULMONARY ARTERY PRESSURE (MPAP) > 20 MMHG.
The World Health Organization recognizes five groups of pulmonary hypertensions:
- • Estimated that > 50% of patients with left heart disease are also affected by pulmonary hypertension.1
- 1 in 4 Americans will develop heart failure in their lifetime.
- Gold standard for diagnosis of PH is a right heart catheterization (RHC).3
- Global burden of PH remains unknown as this illness is poorly surveilled and cases remain underestimated.4,5
Assessing Barriers To Upward Mobility In The Cape Fear Region, Sabrina T. Cherry, Christopher R. Prentice
Assessing Barriers To Upward Mobility In The Cape Fear Region, Sabrina T. Cherry, Christopher R. Prentice
Journal of Sustainable Social Impact
Researchers explore upward mobility to better understand how economic and employment factors drive or undermine social justice and equity in the United States. This scholarship can inform activists and researchers seeking to design solutions that help overcome systemic challenges to upward mobility. Therefore, as an interdisciplinary team of scholars in a public university, we collaborated with community partners to conduct a case study in which we assessed the barriers to—and the drivers of—upward mobility in a medium-sized city in Southeastern North Carolina. We conducted key informant interviews and focus groups with a cross-section of local residents to learn about their …
Hay: A Hedonic Study, Chester R. Broadbent
Hay: A Hedonic Study, Chester R. Broadbent
All Graduate Reports and Creative Projects, Fall 2023 to Present
Hedonic price theory posits that the price of a product is influenced by the values consumers assign to its individual attributes. Hay is a versatile commodity with variation across several attributes helping to cater to diverse needs of consumers. A detailed analysis using hedonic regression techniques within hay pricing can help producers, stakeholders, and educators more fully understand the marginal values consumers place on diverse hay attributes. Previous studies focused on limited scopes within the hay industry or other sectors, allowing room for broader investigation. This study examines qualitative attributes impacting hay pricing, revealing significant influences from factors like location, …
You’Re Testing My Patients: Clinicians’ Preferences For Structured Reporting And Measurement Data, Davit Melik, Adela Pouzar, Allan Brazier, Sayf Al-Katib
You’Re Testing My Patients: Clinicians’ Preferences For Structured Reporting And Measurement Data, Davit Melik, Adela Pouzar, Allan Brazier, Sayf Al-Katib
Posters
Radiological reports are a crucial part of patient care and management. Radiologists play a major role in patient care by interpreting imaging studies and making recommendations to referring physicians. 1,2,3 Although some physicians may prefer to initially interpret the imaging studies by themselves, radiologists’ reports have been shown to be significantly more accurate and detailed, which ultimately results in better patient care. 1,4,5,3 Thus it is important for radiology reports to be timely and as accurate as possible to improve overall patient care. The clarity of communication between radiologists and referring physicians in these reports remains an important factor in …
Study Of Morphology, Structure, And Magnetic Properties Of High Entropy Alloy Systems, Matthew G. Guerrero
Study Of Morphology, Structure, And Magnetic Properties Of High Entropy Alloy Systems, Matthew G. Guerrero
Open Access Theses & Dissertations
Abstract:This thesis presents an investigation into the magnetic properties of high entropy alloy (HEA) samples, focusing primarily on compositions within the FeNiCoMn system and their gallium/chemically doped derivatives. High entropy alloys represent a promising class of materials with unique properties resulting from their complex composition and structural arrangements. The behavior of these alloys, particularly in their magnetic properties, remains an area of significant interest due to their potential applications in magnetic storage, sensing, and other technological domains. The study encompasses an examination of seven distinct HEA samples: FeNiCo, FeNiCoMn0.2, FeNiCoMn0.4, FeNiCoMn0.6, FeNiCoMn0.2Ga0.1, FeNiCoGa0.2, FeNiCoMn0.2Ga0.3. Furthermore, three samples of FeNiCoMn0.2 and …
Mechanical Stability Of Body-Centered Cubic Iron In Born-Von Kármán Parameter Space Using Evolutionary Algorithms, Amir Husen
Open Access Theses & Dissertations
This study aims to assess the mechanical stability of body-centered cubic (BCC) structure, focusing on pure iron as a representative case. The primary approach involves utilizing phonon dispersion curves analysis to gain insights into the vibrational properties and overall stability of the crystal lattice through a multi-faceted computational approach. The goal of the study is to find the regions (pockets) in Born-von Kármán (BvK) parameter space where the crystal is stable for certain temperature and pressure.
This involves setting up the crystal parameters, creating a body-centered cubic (BCC) crystal with specific lattice parameters (2.86 for iron) establishing force constants, and …
Biofabrication Of Human Tissue-On-A-Chip Models Using Engineered Biocompatible Electrospun Scaffolds, Zayra Naomi Dorado
Biofabrication Of Human Tissue-On-A-Chip Models Using Engineered Biocompatible Electrospun Scaffolds, Zayra Naomi Dorado
Open Access Theses & Dissertations
This study explored the adoption of furfuryl gelatin (F-gelatin) based electrospun scaffolds compared with poly-caprolactone (PCL) as promising biomaterials for tissue engineering applications. Tissue-on-a-chip models, incorporating F-gelatin and PCL electrospun scaffolds, offer promising avenues for healthy and disease-in-vitro tissue models that can be explored to investigate underlying physiological mechanisms involved in disease development. Previous research has demonstrated the cytocompatibility of F-gelatin when used for modifying implant surfaces and tissue repair applications [1]. Our earlier published works have also successfully utilized F-gelatin for in-vitro cardiac tissue engineering [2][3]. We designed F-gelatin and PCL electrospun scaffolds to replicate the native tissue extracellular …