Digital Commons Network^™

Neuroprotective Effects Of Sorghum Polyphenol In Alzheimer’S Disease: In Vitro And In Silico Analyses, Rasheed A. Abdulraheem, Ralph N. Martins, Rajapandiyan Krishnamoorthy, Mohammad A. Alshuniaber, Prashant Bharadwaj, Zhaoyu Li, Ranil Coorey, Vijay Jayasena, Stuart K. Johnson, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Background/Objective: Accumulation of amyloid-beta (Aβ) senile plaques in the human brain is a major hallmark of Alzheimer’s disease (AD), which manifests as progressive decline in memory and cognitive functions and currently lacks effective disease-modifying therapies. Emerging evidence demonstrates that polyphenol-rich plant foods are potential complementary therapies for AD. Methods: In this study, we investigated crude polyphenol extracts (CPEs) and purified polyphenol extracts (PPEs) from three sorghum genotypes for their ability to inhibit Aβ42-induced toxicity in MC-65 cells. Thioflavin T fluorescence, cell viability, mitochondrial function, oxidative stress assays, and Western blotting, along with RNA sequencing and computational analyses, were used to …

Optimal Co2 Storage Interval In Heterogeneous Tight Formation: Implications For Long-Term Carbon Sequestration, Yujie Yuan, Yuxin Cao, Emad A. Al-Khdheeawi, Maxim Lebedev, Zhenjiang You, Reza Rezaee, Stefan Iglauer, Lai Chang Zhang, Zhuo Feng

Research outputs 2022 to 2026

The efficiency of CO2 geo-sequestration relies heavily on the storage capacity and sealing integrity of the heterogeneous strata. Tight formations offer substantial advantages for long-term CO2 geological storage, however, the stratigraphic variability and lithological heterogeneity introduce substantial uncertainty in real-world engineering applications. Particularly, for tight formations with pronounced heterogeneous lithologies, traditional methods oversimplify their impact on CO2 geo-sequestration. To address this challenge and identify the most effective intervals for CO2 geo-sequestration, we investigated the middle Permian Lucaogou Formation (P2l) in the Jimusar Sag, Junggar Basin, Northwest China, a region known for its strong lithological heterogeneity. By integrating multi-scale analytical techniques, …

Semantic Context Improvisational Retrieval-Augmented Generation For Empathic Conversational Ai, Sharjeel Tahir, Judith Johnson, Jumana Abu-Khalaf, Syed Afaq Ali Shah

Research outputs 2022 to 2026

A fundamental limitation of modern conversational AI is its limited capacity to demonstrate sustained empathy in long-form interactions. We propose SCIRAG (Semantic Context Improvisational Retrieval-Augmented Generation), a feedback-driven retrieval framework for adaptive empathic dialogue. It employs a dual-loop retrieval framework, iteratively optimizing a static counseling dataset through user metadata and feedback memory refinement. To enhance contextual alignment, we deploy retrieval adaptation, enabling the model to retain and leverage past conversational cues based on user preferences. When integrated with Mixtral-8x7B, SCIRAG improves human-rated empathic understanding by +1.26 points and empathic response by +1.00 point on the RoPE scale, while increasing acceptability …

A Remarkable Diversity Of Syngnathid Fishes In A Highly Modified Large Coastal Embayment In The Southeastern Indian Ocean, Glenn I. Moore, Jenelle A. Ritchie, Georgia M. Nester, Glenn A. Hyndes, Alan J. Kendrick

Research outputs 2022 to 2026

Southern Australia supports a high diversity of fishes in the family Syngnathidae, which is recognised as globally threatened, facing threats from coastal development, over-exploitation and bycatch. In southwestern Australia, Cockburn Sound houses a large industrial port and naval defence assets with plans to substantially expand the port facilities but also sits within a recognised syngnathid ‘hotspot’. Using a broad array of data sources, including historical museum vouchers, published records, historical and contemporary observations from notebooks and diving surveys, historical and contemporary trawl surveys, citizen science observations and environmental DNA, we compiled 4839 records of syngnathid fishes from the embayment. Twenty-one …

Dasyurus Hallucatus Movement Response To Fire In A Complex, Resource Rich Tropical Savanna, Ian J. Radford, Annette Cook, Natasha Harrison, Ben Corey, Roberta Bencini, Harriet R. Mills

Research outputs 2022 to 2026

The northern quoll, Dasyurus hallucatus, is part of a suite of threatened native northern Australian mammals that have inappropriate fire regimes listed as a threatening process. However, fire responses reported for D. hallucatus are inconsistent among different studies. Based on the theory that the fire response of D. hallucatus will depend partially on habitat quality, we postulate that home range in high quality savannas of the north Kimberley will be small, post-breeding male mortality low and prey resources little affected by fire. Based on previous research we hypothesised that male D. hallucatus would respond to fire more than females. By …

Forecast: An Exhibition Inviting Slow Feeling Through Participation In Unstable Weather States, Jo Pollitt, Helena Grehan, Lilly Blue, Peggy Attkinson, Justine Dandy, Naomi Joy Godden, Leanda Mason, Renee Esther Newman, Alexa Taylor, Danielle Gilson

Research outputs 2022 to 2026

This paper presents a series of responses from Western Australian based artists and scholars from a range of disciplines including: meteorology, science, education, social work, psychology, art and performance studies, to a year-long exhibition titled Forecast in Gallery 09 at The Art Gallery of Western Australia (AGWA). Forecast is a collaboration between AGWA's Head of Learning and Creativity Research, Lilly Blue, Edith Cowan University's Centre for People, Place and Planet artist-scholar, Jo Pollitt, together with artists Dianne Jones and Eva Fernández. The exhibition invites audiences to contribute to two participatory works: Weather Patterns, a daily changing installation that makes room …

Genome-Wide Cline Analysis Identifies New Locus Contributing To A Barrier To Gene Flow Across An Antirrhinum Hybrid Zone, David L. Field, Sean Stankowski, Taylor Reiter, Jitka Polechova, Desmond Bradley, Daniel M. Richardson, Annabel Whibley, Arka Pal, Daria Shipilina, Louis Boell, Melinda Pickup, Yongbiao Xue, Enrico Coen, Nicholas Barton

Research outputs 2022 to 2026

Identification of the genomic regions that contribute to reproductive isolation and how they interact is a major goal of evolutionary genetics. Much effort has focused on locating candidate genes and potential barrier loci by scanning genomes for regions of excess differentiation (FST). An alternative, and perhaps more robust approach, is to scan for genomic regions exhibiting steep clines in allele frequency across a hybrid zone. We develop a computationally efficient method for approximating cline parameters for large number of loci, and apply it to genomic data from across a hybrid zone between flower colour varieties of Antirrhinum majus (A. m. …

Healthcare Professionals’ Experiences And Perspectives On Self-Management Education For Breast Cancer Survivors In Australian Primary Care: A Qualitative Study, Meng Yuan Li, Tao Wang, Daniel Terry, Haiying Wang, Isabella Zhao, Jing Yu Tan

Research outputs 2022 to 2026

Purpose: Breast cancer has been recognised as a chronic condition, with survivors experiencing long-term physical and psychosocial effects following treatment. Supporting breast cancer survivors to self-manage their health can optimise health-related quality of life and reduce symptom burden. Self-management education (SME) has been advocated at the policy and programme level in Australian primary care, but its uptake is often limited. This study explores healthcare professionals’ (HCPs) experiences and perceptions of SME in primary care, aiming to identify factors influencing its implementation and to support survivorship care for breast cancer survivors in Australia.

Methods: A qualitative descriptive approach was adopted involving …

Peripheral Nerve Sensory Fibers Are Recruited With Less Current And Greater Selectivity By Conventional Waveforms Compared With High-Frequency Waveforms, Janie Provencher, Harrison T. Finn, Janet L. Taylor, Simon C. Gandevia, Jane E. Butler, Martin E. Héroux

Research outputs 2022 to 2026

Transcutaneous spinal stimulation aims to target dorsal spinal roots, which deliver sensory information to the spinal cord. However, the stimulation waveform that most effectively recruits sensory fibers at the lowest intensity has not been identified. The purpose of this study was to compare conventional and high-frequency burst-modulated stimulation waveforms in their ability to recruit sensory fibers, as assessed by H-reflex threshold, recruitment characteristics, and motor fiber activation. In participants with intact neurological function (n ¼ 12), soleus H-reflex recruitment curves were recorded for 10 stimulation waveforms: a conventional waveform (400 μs), serving as the reference condition, high-frequency burst-modulated waveforms (2, …

Rhetorical Physics And The Laws Of Language: A Comparative Analysis Of President Trump And President Macron At The United Nations 2025, David Edmund Allen

Research outputs 2022 to 2026

The paper features a textual analysis of the UN speeches made by the US President Donald Trump and by France’s President Macron. President Trump’s speech was made in the absence of a teleprompter and lasted almost an hour. President Macron’s speech was representative of a more standard diplomatic speech. Both speeches are analyzed using a variety of models and techniques. The analysis incorporates an exploration of Manin’s link of Zipf’s law to concepts from information theory and algorithmic complexity, Tao’s concepts applied to power laws, ‘E pluribus unum’, out of many, one, plus a completely new application of Villermaux’s universal …

Story, Mapping And “Jarriny”: A Collaborative Exploration Of Artistic Responses To Extreme Weather In The Work Of Natalie Davey And The 2023 Fitzroy River Floods, Natalie Davey, Renée Newman

Research outputs 2022 to 2026

Extreme weather events caused by human created climate change not only cause catastrophic impact on human and the more-than-human populations but can also trigger permanent changes to place. With these changes, stories shift, in turn influencing knowledge and cultural systems. This article is a dialogue between Natalie Davey and Renée Newman, about the role of art, story, mapping and “jarriny” (translating to totem) as a tool for education on extreme weather events and climate crisis. We also consider the vital role custodianship plays in response to and recovery from an extreme weather event, as was the case for Natalie Davey …

The Poly-Arginine Peptide R18d Inhibits Amyloid-Beta (Aβ) Aggregation And Aβ-Induced Cytotoxicity, Reduces Intracellular Tau Aggregation, And Exhibits Oral Bioavailability, Vaishali Bagda, Zainab H. Farooz, Neville W. Knuckey, Samantha M. South, Stuart K. Gribble, Maitri Tomar, Prashant Bharadwaj, Ajish Ariyath, Kevin Taddei, Ralph N. Martins, Bruno P. Meloni

Research outputs 2022 to 2026

Background/Objectives: Effective disease-modifying therapies targeting pathogenic proteins associated with Alzheimer’s disease (AD) remain limited. This study investigated the therapeutic potential of the neuroprotective, cationic arginine-rich peptide R18D to mitigate the pathogenic effects of amyloid-beta (Aβ) and tau associated with AD.

Methods: R18D was examined for its ability to inhibit Aβ aggregation in a cell-free assay, attenuate Aβ-induced cytotoxicity in MC65 cells, and suppress intracellular tau aggregation in two neural cell models. Intracellular tau aggregation was quantified using a homogeneous time-resolved fluorescence assay. Additionally, a pilot pharmacokinetic study of R18D was conducted in mice following oral gavage administration.

Results: In the …

Urinary Sodium, Table Salt Use And Incidence Of Late-Onset Asthma In Females And Males: Evidence From A Large Prospective Cohort, Selma Kronsteiner-Gicevic, Alysha S. Thompson, Martina Gaggl, Aedín Cassidy, Nicola P. Bondonno, Charmaine J.M. Lim, Robab Breyer-Kohansal, Tilman Kühn

Research outputs 2022 to 2026

Background: The contribution of dietary sodium to asthma development remains unclear, particularly for adult-onset disease. We examined associations between estimated 24-h urinary sodium excretion, table salt use and incident asthma in a large prospective cohort.

Methods: We analysed 420 041 adults aged 40–69 years without prior asthma. Incident asthma was ascertained through linked health records. Urinary sodium was estimated using the INTERSALT equation from spot urine samples. Frequency of adding salt at the table was self-reported. Associations were evaluated using multivariable Cox proportional hazards models with adjustment for sociodemographic, lifestyle and clinical factors.

Results: Over a median 10.9-year follow-up, 11 …

Weathering In-Beyond Hydro(S)Cenes, Bronwyn Bailey-Charteris, Kathryn Mcmahon, Mary Christina Rapp, Natalie Davey

Research outputs 2022 to 2026

This paper examines the cultural, ecological and political dimensions of the contemporary water crisis through a curatorial and environmental humanities lens. Through the watery conceptual epoch of the Hydrocene, it highlights the work of artists and interdisciplinary practitioners whose hydro-Artistic methods propose ways to realign human-water relations. Central to this analysis is the role of curatorial care, here understood as a practice of convening, holding and enabling reciprocal encounters between bodies of water, artists and communities. Bringing these diverse practices into dialogue, the paper proposes water not only as subject matter but as a potential collaborator and leaky agent. It …

Why Are Western Australian Girls Less Motivated Than Boys To Study Senior Secondary Higher-Level Mathematics Courses? Relationships Between Gender, Prior Achievement, And Mathematics Course Aspirations, Jane Kirkham, Elaine Chapman

Research outputs 2022 to 2026

Secondary school students, and particularly girls, may avoid enrolling in higher-level mathematics courses despite having the competence to succeed in these courses. Understanding the reasons behind these choices is essential to addressing this concern. In this study, the teachers of Western Australian Year 10 students (n=886) nominated the mathematics course in which they believed each participating student could succeed in Year 11 with participants grouped into four achievement cohorts on this basis. Then each teacher course nomination was compared to participants’ own course selection with participants classified as either aspiring below or at/above their judged potential achievement level. We then …

More Than Just Fair: Legitimizing Ai Through Reciprocity, Ethical Ai Characteristics And Personal Information Sharing, Shahid Hussain, Asim Qazi, Violetta Wilk

Research outputs 2022 to 2026

This research examines how perceived reciprocity and perceived ethical AI characteristics – fairness, accountability, and transparency (FAT principles) – shape consumers’ willingness to share personal information and its downstream consequences in AI-mediated consumer-brand interactions. Grounded in social exchange theory, we conceptualize personal information sharing as a behavioral gateway through which ethical exchange cues translate into perceived algorithmic legitimacy and intention to co-create value. Using a two-study design, consisting of a scenario-based experiment (n = 184) and a cross-sectional survey (n = 612), the findings of this research show that reciprocity and FAT principles robustly increase willingness to share personal information. …

A Scalable Workflow Using Digital Cognitive Assessment And Ptau217 For Mci Detection, Srinivasan Vairavan, Nicholas Griffin, David Wilson, Gallen Triana-Baltzer, Victoria Brugada-Ramentol, Elena Vera-Campuzano, Daniel Alcolea, Silvia Fallone, Lucy Mackintosh, Lindsey Mette, James D. Doecke, Joanne Robertson, Larry Ward, Gonzalo Sánchez Benavides, Carolina Minguillon, Clàudia Porta Mas, Adrià Tort-Merino, Mircea Balasa, Oriol Grau Rivera, Marc Suárez Calvet, Lewis Taylor, Íñigo Rodríguez-Baz, Javier Arranz, Juan Fortea, Ioannis Tarnanas, Marc Jones, Gayle Wittenberg, Emmanuel Streel, Maria Florencia Iulita

Research outputs 2022 to 2026

Introduction: Blood biomarkers like phosphorylated tau (p-tau)217 offer high diagnostic accuracy for Alzheimer's disease (AD) but face implementation challenges in low-prevalence settings. We evaluated the Altoida NeuroMarker Platform as a digital cognitive triage tool before plasma p-tau217 testing.

Methods: XGBoost models were trained to predict mild cognitive impairment (MCI) and p-tau217 status in 688 individuals across Australia, Spain, and the United States using the Altoida NeuroMarker. p-tau217 status was dichotomized using a threshold of 0.04 pg/mL (LucentAD). We modeled a two-step workflow (Altoida, plasma p-tau217) to enrich downstream biomarker testing, assuming 30% prevalence of AD pathology.

Results: The Altoida NeuroMarker …

Nursing Students' Evaluation Of Primary Health Care Clinical Placements - A Cross-Sectional Study, Debbie Procter, Megan Lee, Debbie Massey, Kylie Mccullough, Karen Strickland

Research outputs 2022 to 2026

Aim: Evaluate quality and satisfaction of nursing students' Primary Health Care clinical placements. Background: There is growing recognition of the need to expand the Primary Health Care nursing workforce, with positive clinical placement experiences considered essential for preparing and inspiring future careers in these settings; however, few graduate nurses choose this career path. Design: A cross-sectional study design using purposive sampling. Participants: Data were sourced from National Placement Evaluation Centre's 2023/2024 dataset using the validated PET–Nursing survey. The tool includes 20 items across two subscales - Clinical Environment and Learning Support, with the final item assessing overall placement satisfaction. Surveys …

The Anatomy Of Earnings Conference Calls: An Integrative Framework For Management Research, Matthew P. Mount, Gokhan Ertug, Wei Shi, Tengjian Zou

Research Collection Lee Kong Chian School Of Business

Over the last decade, there has been an explosion in the use of diverse data sources by management scholars to observe and capture managerial and organizational constructs that have historically been difficult to access. This surge has been driven by the growing availability of rich, multi-modal data—textual, image, and audio (Luo, Jia, Ouyang, & Fang, 2024)—together with advances in analytical techniques to process and analyze data, such as computer-aided text analysis (Harrison, Thurgood, Boivie, & Pfarrer, 2019), machine learning (Choudhury, Wang, Carlson, & Khanna, 2019; Harrison, Josefy, Kalm, & Krause, 2023), and deep learning (Gouvard, Goldberg, & Srivastava, 2023). These …

Effects Of Targeted Interventions On Hiv Testing, Knowledge And Sexual Risk Behaviours Among Long-Distance Truck Drivers: A Systematic Review And Meta-Analysis, Cyrus Mutie, Berrick Otieno, Kawira Kithuci, John Gachohi, Grace Mbuthia

School of Nursing & Midwifery, East Africa

Objectives We aimed to systematically summarise and quantify the empirical evidence on targeted interventions and their effects on various HIV prevention outcomes for long-distance truck drivers (LDTDs) globally.

Design A systematic review and meta-analysis.

Data sources We searched PubMed, PubMed Central (PMC), Cumulated Index to Nursing and Allied Health Literature (CINAHL), ProQuest Central, EBSCOhost, ScienceDirect, World Health Organisation (Global Index Medicus), Cochrane Library, Scientific Electronic Library Online (SCiELO), Japan Science and Technology Information Aggregator, Electronic (J-STAGE) and China National Knowledge Infrastructure (CNKI) up to 15th May 2026.

Eligibility criteria We included original peer-reviewed interventional studies involving LDTDs of either gender …

The Vision-Enhanced Occupational Engagement Program, Zakoria Q Fox Mcelroy, Rebecca King

Summer 2026 OTD Capstone Symposium

Background: Low vision is a significant concern among older adults and can affect independence, mobility, safety, social participation, and overall quality of life. As the aging population continues to grow, understanding the challenges experienced by older adults with low vision is increasingly important for improving supportive services and promoting healthy aging.

Purpose: This capstone project examined the experiences and needs of older adults living with low vision, with a focus on how vision loss and environmental factors may influence daily functioning, independence, and participation in meaningful occupations.

Methods: A multi-method needs assessment was completed to identify the needs of residents …

Climate Change Education For Environmental Sustainability In Health Professions Education: A Modified Delphi, Moses Mutua, Mirriam Kivuva

School of Nursing & Midwifery, East Africa

No abstract provided.

Legal Terminology, Or: How Do Definitions Work For You?, Liliana Tymchenko

GHEA21 Publications

No abstract provided.

Building A Toolkit Of Writing-Based Learning Activities For Finance Classes, Esther Afoley Laryea

GHEA21 Publications

No abstract provided.

Cultivating Critical Thinkers And Problem Solvers In Esl Classrooms Amid Political Unrest: Integrating Iwt Clasp Approaches, Reginald Louis

GHEA21 Publications

No abstract provided.

The Study Of How Sensory Marketing Techniques Used By Beauty Brands Influence Engagement And Consumer Perception On Social Media Platforms, Particularly By Evoking Specific Consumer Emotions, Eeshani Juthani

Digital Marketing Theses

This study describes how a consumers' attitude towards beauty products on social media is affected by sensory marketing techniques and cues. This study also examines how sensory marketing tactics and elements such as sight, sound, smell, touch, and taste affects the way a consumer engages with content on social media platforms like Tiktok and Instagram.

Hiding In Plain Sight: A Case Of Intestinal Tuberculosis Masquerading As Benign Lower Gi Bleeding, Lavender Otom, Priyanka Panwar, Gerald Odong, Fatma Kassim, Patricia Okiro, Christopher Opio, Saleem Abdulkarim

Internal Medicine, East Africa

Background Intestinal tuberculosis (TB) represents the most common form of abdominal TB, often affecting the ileocaecal region. Lower gastrointestinal bleeding is an uncommon presentation and may create significant diagnostic uncertainty, particularly in immunocompromised patients and in settings where inflammatory bowel disease is also encountered.

Case Presentation A woman in her sixties from Africa presented with recurrent diarrhoea and intermittent haematochezia over a 6-month period. Initial endoscopic evaluation was nondiagnostic. Cross-sectional imaging later demonstrated multifocal bowel involvement affecting both the small and large bowel, including ileocaecal and rectoanal disease, with associated abdominopelvic lymphadenopathy. Histopathology from repeat colonoscopy biopsy showed caseating granulomas …

May Measurement Month 2023: Results Of An Opportunistic Blood Pressure Screening Campaign In Kenya, Mzee Ngunga, Thomas Beaney, Gabriele Kerr, Bernard Samia, Lilian Mbau, Neil Poulter, Hellen Nguchu, Jeilan Mohamed, Elijah Ogola

Internal Medicine, East Africa

The May Measurement Month (MMM) is a global screening campaign launched in 2017 to raise awareness of raised blood pressure (BP). Kenya has participated in all previous MMM campaigns. Adults aged ≥18 years were recruited through convenience sampling in nine counties of Kenya. Three seated BP readings were taken on each participant, and a questionnaire collected information on demographics, lifestyle factors, and comorbidities. Hypertension was defined as a systolic BP ≥140mmHg or diastolic BP ≥90mmHg or being on BP-lowering medication. Controlled BP was defined as being on BP-lowering medication with a BP < 140/90mmHg. Multiple imputation was used to estimate missing BP readings. In total, 4,601 were screened, with a mean age of 41.7 years and 42.7% were female. Of all participants, 1,176 (25.6%) had hypertension, of whom 198 (16.8%) were aware, and 190 (16.2%) were on antihypertensive medication. Of those on antihypertensive medication, 65 (34.2%) had controlled BP, and of all participants with hypertension, 5.5% had controlled BP. The mean systolic and diastolic BPs of those on treatment was significantly higher than those without hypertension. Hypertensive disease in a previous pregnancy was associated with higher BP amongst female participants.

The MMM campaign in Kenya identified a substantial …

Current Trends In Remote Sensing-Based Harmful Algal Bloom Research: A Bibliometric Analysis, Joshua T. Ruiz

Research Papers

No abstract provided.

Robot Remote Control Utility, Jeremy Cantu, Paul Uhlig

Systems Manuals - 2026

The purpose of this document is to describe the Robot Control Management Utility developed in the course of this graduate project. Information included in this document will include the background of the developed product, as well as the functional requirements, data structures, software modules, interface design, installation guide, and sample and troubleshooting guides.