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Ud In The News Jan. 10-17, University Of Dayton Jan 2025

Ud In The News Jan. 10-17, University Of Dayton

News Releases

Business Insider, La Vanguardia in Spain and Catholic outlets nationwide interviewed UD faculty. Several regional and local outlets highlighted UD's Choose Ohio First award from the state of Ohio.


Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica Jan 2025

Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica

Walden Dissertations and Doctoral Studies

Producing enough food to feed a growing human population without further degrading the environment through unsustainable natural resource use is a global issue. The purpose of this quantitative nonexperimental study was to examine the extent to which big data management of environmental impact sources, assessment methods, and allocation methods in multi-objective optimization (MOO) modeling affect the consistency and predictability of sustainable food animal feed management practices at the farm level. Representation theory, the theory of effective use of information systems, the dynamic capabilities view, and the natural resource-based view were used to describe the necessity of accurately representing and managing …


Elementary School Teachers’ Perspectives Regarding Handwriting Fluency And Writing Proficiency In Elementary Students, Sofia Doyle For Scott Doyle Jan 2025

Elementary School Teachers’ Perspectives Regarding Handwriting Fluency And Writing Proficiency In Elementary Students, Sofia Doyle For Scott Doyle

Walden Dissertations and Doctoral Studies

The problem that was addressed in this study is that the majority of students nationwide demonstrate low writing proficiency and handwriting fluency. The purpose of this study was to explore elementary school teachers’ perspectives regarding handwriting fluency and its role in the overall writing skills of elementary students. This study was grounded in Piaget’s cognitive learning theory. Four research questions focused on teachers’ perspectives; two questions focused on factors that contribute to low achievement in handwriting and writing proficiency and two questions asked teachers about their experiences with the strategies they used to support students in handwriting and writing achievement. …


Executive Summary: Quality Improvement Initiative Reducing Er Readmissions Among Homeless Individuals With Schizophrenia Using Integrated Care, Chiamaka Nnah Jan 2025

Executive Summary: Quality Improvement Initiative Reducing Er Readmissions Among Homeless Individuals With Schizophrenia Using Integrated Care, Chiamaka Nnah

Walden Dissertations and Doctoral Studies

This evaluation of the effectiveness of a quality improvement initiative project aimed to reduce ER readmissions and improve medication adherence among homeless individuals with schizophrenia by implementing an integrated care model. These individuals face substantial barriers to healthcare, including housing instability and limited access to resources, leading to frequent ER visits that strain healthcare systems. Addressing this issue is essential for nursing practice to optimize resource use and improve patient outcomes. The project examined whether a coordinated approach integrating medical and social services could lower ER visits and enhance adherence to treatment. Statistical analyses showed that postimplementation medication adherence increased …


Shifting Perspectives: Valuing Art For Its Usefulness, Not Just Its Aesthetics, Morgan Hatfield Jan 2025

Shifting Perspectives: Valuing Art For Its Usefulness, Not Just Its Aesthetics, Morgan Hatfield

SPARK Symposium Presentations

Art is everywhere. From paintings, to entertainment, even to gardening and architecture, art is an essential part of society and culture. However, art can frequently be trapped in its own bubble, seen as something of not much use to “real” professionals such as physicians, therapists, or scientists. This line of thinking discredits the flexibility of art. It is only through the analysis of art’s impact on society that one can see the broad array of disciplines that art can affect and thus see the true value of art. Focusing primarily on visual art, I seek to place a value on …


School Travel Behaviors In Rural Communities: Pandemic-Related Impacts, Kevin Chang, Xinyi Li, Ahmed Abdel-Rahim Jan 2025

School Travel Behaviors In Rural Communities: Pandemic-Related Impacts, Kevin Chang, Xinyi Li, Ahmed Abdel-Rahim

CSET Project Reports

The global pandemic, which started around early 2020, significantly disrupted life for many families, and the trip to and from school was not immune to these disruptions. Parents and children alike made travel adjustments depending on their preferences with regard to personal health and safety, social distancing, and aversion to risk. Each school district and individual school also made decisions with regard to in-person or remote learning during this period of uncertainty. In this study, the research team examines how the pandemic affected school transportation for hundreds of families across the Pacific Northwest. An online survey was developed and administered …


Lumen-Apposing Metal Stent Placement In Severe Sepsis Secondary To Afferent Limb Syndrome, Nicholas Noverati, Faisal Kamal Jan 2025

Lumen-Apposing Metal Stent Placement In Severe Sepsis Secondary To Afferent Limb Syndrome, Nicholas Noverati, Faisal Kamal

Division of Gastroenterology and Hepatology Faculty Papers

No abstract provided.


A Comparison Of Energy Dispersive Spectroscopy In Transmission Scanning Electron Microscopy With Scanning Transmission Electron Microscopy, Jennifer L.W. Carter, Tugce Karakulak Uz, Jeffrey S. Pigott Jan 2025

A Comparison Of Energy Dispersive Spectroscopy In Transmission Scanning Electron Microscopy With Scanning Transmission Electron Microscopy, Jennifer L.W. Carter, Tugce Karakulak Uz, Jeffrey S. Pigott

Faculty Scholarship

The objective of this work was to explore the capabilities of a field emission gun scanning electron microscope (FEG-SEM) equipped with a transmission scanning electron detector (TSEM) and energy dispersive spectroscopy (EDS) to identify nanoscale chemical heterogeneities in a gas atomization reaction synthesis (GARS) steel sample. The results of this analysis were compared to the same study conducted with scanning transmission electron microscopy (STEM) with EDS mapping. TSEM-EDS was performed using the standard spectral analysis approach, i.e., pixel-by-pixel identification of elements from the spectra, and a new principal component analysis approach to detect regions of similar spectra before identifying elemental …


Perceptions And Practices Of Imaging Personnel And Physicians Regarding The Use Of Brain Mri For Dementia Diagnosis In Uganda, Stephen E. Jones, Martha Sajatovic Jan 2025

Perceptions And Practices Of Imaging Personnel And Physicians Regarding The Use Of Brain Mri For Dementia Diagnosis In Uganda, Stephen E. Jones, Martha Sajatovic

Faculty Scholarship

Introduction Diagnosing dementia remains challenging in low-income settings due to limited diagnostic options and the absence of definitive biomarkers. The use of brain MRI in the diagnosis of dementia is infrequent in Uganda, and even when it is used, subtle findings like mild regional atrophy are often overlooked, despite being crucial for imaging diagnosis. Objective The purpose of this study was to explore the perceptions and practices of imaging personnel and physicians regarding the use of brain MRI as a diagnostic approach for dementia in Uganda. Methods This was an exploratory qualitative study involving radiologists, technologists, senior house officers and …


The Mcdonaldization Of Academic Sociology, J. Michael Ryan, George Ritzer, Hermann Strasser Jan 2025

The Mcdonaldization Of Academic Sociology, J. Michael Ryan, George Ritzer, Hermann Strasser

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.


Marketing With A Social Conscience: Strategic Windows For Aligning Societal Marketing With Corporate Identity, Christopher Agyapong Siaw Jan 2025

Marketing With A Social Conscience: Strategic Windows For Aligning Societal Marketing With Corporate Identity, Christopher Agyapong Siaw

Plymouth Business School

PurposeThis study proposes a conceptual framework for strategically integrating societal marketing (SM) into corporate identity to effectively represent a firm’s SM programs to stakeholders. The framework is crucial for firms to align their SM efforts with their identity in a manner that minimizes, if not eliminating, the accusations of dishonesty, such as greenwashing, brownwashing, or greenhushing.Design/methodology/approachDrawing on corporate identity theory and synthesizing the literature on SM, the study identifies three levels of corporate identity (strategic, operational, and functional) and three dimensions of SM’s alignment with business objectives (direct, indirect, and remote). Subsequently, the study develops a conceptual framework based on …


Investigating Student Experiences With Math Anxiety, Wendy Elaine Davis Jan 2025

Investigating Student Experiences With Math Anxiety, Wendy Elaine Davis

Student Theses and Dissertations

Math anxiety is a fear of math-related activities. The problem addressed in this study is the lack of understanding of the link between math anxiety and math performance. Students and educators are affected by math anxiety. The fear of math can also affect individuals when completing real-world activities such as filing taxes, calculating sales discounts, or computing percentages. The purpose of this phenomenological qualitative study was to investigate how students who self-identify as having math anxiety perceive its effects on their mathematical performance. It also sought to identify types of events or academic experiences that contribute to math anxiety. The …


Fort Hays State University Tiger Weekly, January 17, 2025, University Relations Jan 2025

Fort Hays State University Tiger Weekly, January 17, 2025, University Relations

Tiger Weekly Newsletters

No abstract provided.


First-Generation African American College Graduates’ Interpretations Of Poverty And Well-Being, Shermanda Bellsora Whitfield Jan 2025

First-Generation African American College Graduates’ Interpretations Of Poverty And Well-Being, Shermanda Bellsora Whitfield

Walden Dissertations and Doctoral Studies

The number of first-generation African American graduates of postsecondary institutions has grown, as many individuals perceive degree completion as a way to overcome socioeconomic barriers. The problem was that some first-generation African American college graduates face economic challenges postgraduation, living at or below the poverty level. It was unclear how this condition affected their quality of life. The purpose of this generic qualitative study was to understand how African American first-generation college graduates interpreted and made meaning of their experiences related to their financial status and personal well-being. Bronfenbrenner’s ecological systems was the theoretical framework. Data were collected through semi-structured …


Impact Of Leadership Characteristics Of Empowerment And Support Of Employee Growth On Job Commitment And Turnover Intent Of Nurses In Ghana, Ernest Addai Duah Jan 2025

Impact Of Leadership Characteristics Of Empowerment And Support Of Employee Growth On Job Commitment And Turnover Intent Of Nurses In Ghana, Ernest Addai Duah

Walden Dissertations and Doctoral Studies

Prior studies have examined leadership style and its relation to healthcare employees’ performance; however, few Ghanaian studies have focused on using characteristics of leaders and their relationship to job commitment and turnover intention among nurses and midwives in the 10 regions of Ghana. The objective for this quantitative correlation study was to examine whether leadership characteristics have a relationship with job commitment and turnover intent among hospital nurses in Ghana, where Upper East was the region of focus. Servant leadership theory was used as the theoretical framework for this study. The study addressed the relationship between leadership characteristics of empowerment, …


Perceptions Of Encouragement For Native American Women To Persist In Doctoral Programs, Venicia Mayo Burton Jan 2025

Perceptions Of Encouragement For Native American Women To Persist In Doctoral Programs, Venicia Mayo Burton

Walden Dissertations and Doctoral Studies

The problem addressed in this study is the underrepresentation of Native American women in doctoral programs in the United States. The purpose of this basic qualitative study was to explore how encouragement in terms of support, confidence, hope, and advice received from family and tribe, friends and social circles, and faculty and college administrators influence the persistence of Native American women in their doctoral journeys. The conceptual framework for this study is the psychosociolcultural theory (PSC) to help examine the psychological, social, and cultural influences on the educational experiences of minority students in an educational setting. Data from eight interviews …


Desktop-Scale Robot Tape Manipulation For Additive Manufacturing, Nahid Tushar, Rencheng Wu, Yu She, Wenchao Zhou, Wan Shou Jan 2025

Desktop-Scale Robot Tape Manipulation For Additive Manufacturing, Nahid Tushar, Rencheng Wu, Yu She, Wenchao Zhou, Wan Shou

School of Industrial Engineering Faculty Publications

Advancements in additive manufacturing and robotic automation have enabled diverse fabrication techniques using various materials. However, small-scale tape placement for three-dimensional (3D) printing remains underexplored, with most research focused on large-scale composite manufacturing using carbon fiber prepreg tapes. This work presents an innovative, automated, and cost-effective tape placement system that extends traditional methods beyond carbon fiber prepreg. We developed a customized tape print module (TPM) integrated with a robotic arm, enabling precise and versatile tape placements. Our system supports non-linear toolpaths, complex patterns, and controllable placements on multi-plane surfaces, creating overhangs without support. We demonstrate circuit printing with copper tape …


Artificial Intelligence For The Detection Of Acute Myeloid Leukemia From Microscopic Blood Images; A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Wael Hafez, Asrar Rashid, Mahir Khalil Jallo, Munier Gador, Ivan Cherrez-Ojeda, Daniel (Centro De Investigación De Salud Pública Y Epidemiología Clínica Simancas-Racines, , Universidad Ute, Quito, Ecuador , Universidad Ute, Quito, Ecuador Jan 2025

Artificial Intelligence For The Detection Of Acute Myeloid Leukemia From Microscopic Blood Images; A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Wael Hafez, Asrar Rashid, Mahir Khalil Jallo, Munier Gador, Ivan Cherrez-Ojeda, Daniel (Centro De Investigación De Salud Pública Y Epidemiología Clínica Simancas-Racines, , Universidad Ute, Quito, Ecuador , Universidad Ute, Quito, Ecuador

All Works

Leukemia is the 11th most prevalent type of cancer worldwide, with acute myeloid leukemia (AML) being the most frequent malignant blood malignancy in adults. Microscopic blood tests are the most common methods for identifying leukemia subtypes. An automated optical image-processing system using artificial intelligence (AI) has recently been applied to facilitate clinical decision-making. To evaluate the performance of all AI-based approaches for the detection and diagnosis of acute myeloid leukemia (AML). Medical databases including PubMed, Web of Science, and Scopus were searched until December 2023. We used the “metafor” and “metagen” libraries in R to analyze the different models used …


To Be Or Not To Be Included In The S&P 500: Cost Of Debt Implications, Matthew Faulkner, Tracie Frost, Stoyu I. Ivanov Jan 2025

To Be Or Not To Be Included In The S&P 500: Cost Of Debt Implications, Matthew Faulkner, Tracie Frost, Stoyu I. Ivanov

Faculty Research, Scholarly, and Creative Activity

Purpose: We examine the changes in a firm’s cost of debt after it is included in or removed from the S&P 500. The extant literature on index composition focuses on the cost of equity and lacks an understanding of the impacts on a firm’s cost of debt capital upon inclusion in or removal from a major stock market index. Therefore, we address the following question: Does a firm’s cost of debt change around its inclusion in or removal from the S&P 500? Design/methodology/approach: We develop two hypotheses based on the research question and use univariate and multivariate fixed-effects analyses to …


Student Reflections On A Summer School To Achieve Sdg 12: A Case Study, Una Beagon, Janet Mckennedy, Ruchita Jani, Brian Bowe, Margaret Morgan, Rosalind Henry Jan 2025

Student Reflections On A Summer School To Achieve Sdg 12: A Case Study, Una Beagon, Janet Mckennedy, Ruchita Jani, Brian Bowe, Margaret Morgan, Rosalind Henry

Research Outputs: 2025-Present

No abstract provided.


Recommendations For Interdisciplinary Research Collaboration For Early Career Dissemination And Implementation Researchers: A Multi-Phase Study, Hannah G Lane, Sallie D Allgood, Julie Schexnayder, Hayden B Bosworth, Ana A Baumann, Allison A Lewinski Jan 2025

Recommendations For Interdisciplinary Research Collaboration For Early Career Dissemination And Implementation Researchers: A Multi-Phase Study, Hannah G Lane, Sallie D Allgood, Julie Schexnayder, Hayden B Bosworth, Ana A Baumann, Allison A Lewinski

2020-Current year OA Pubs

INTRODUCTION: Dissemination and implementation (D&I) scientists are key members of collaborative, interdisciplinary clinical and translational research teams. Yet, early career D&I researchers (ECRs) have few guidelines for cultivating productive research collaborations. We developed recommendations for ECRs in D&I when serving as collaborators or co-investigators.

METHODS: We employed a consensus-building approach: (1) group discussions to identify 3 areas of interest: "Marketing yourself" (describing your value to non-D&I collaborators), "Collaboration considerations

RESULTS: Forty-four D&I researchers completed the first survey, 12 of whom attended one of three focus groups. Twenty-nine D&I researchers completed the second survey (

CONCLUSIONS: Research collaborations are essential in …


First-Generation African American College Graduates’ Interpretations Of Poverty And Well-Being, Shermanda Bellsora Whitfield Jan 2025

First-Generation African American College Graduates’ Interpretations Of Poverty And Well-Being, Shermanda Bellsora Whitfield

Walden Dissertations and Doctoral Studies

The number of first-generation African American graduates of postsecondary institutions has grown, as many individuals perceive degree completion as a way to overcome socioeconomic barriers. The problem was that some first-generation African American college graduates face economic challenges postgraduation, living at or below the poverty level. It was unclear how this condition affected their quality of life. The purpose of this generic qualitative study was to understand how African American first-generation college graduates interpreted and made meaning of their experiences related to their financial status and personal well-being. Bronfenbrenner’s ecological systems was the theoretical framework. Data were collected through semi-structured …


Executive Summary: Quality Improvement Initiative Reducing Er Readmissions Among Homeless Individuals With Schizophrenia Using Integrated Care, Chiamaka Nnah Jan 2025

Executive Summary: Quality Improvement Initiative Reducing Er Readmissions Among Homeless Individuals With Schizophrenia Using Integrated Care, Chiamaka Nnah

Walden Dissertations and Doctoral Studies

This evaluation of the effectiveness of a quality improvement initiative project aimed to reduce ER readmissions and improve medication adherence among homeless individuals with schizophrenia by implementing an integrated care model. These individuals face substantial barriers to healthcare, including housing instability and limited access to resources, leading to frequent ER visits that strain healthcare systems. Addressing this issue is essential for nursing practice to optimize resource use and improve patient outcomes. The project examined whether a coordinated approach integrating medical and social services could lower ER visits and enhance adherence to treatment. Statistical analyses showed that postimplementation medication adherence increased …


Depictions Of United States Military Domestic Violence Found On The Internet, Erica Ann Pearson Jan 2025

Depictions Of United States Military Domestic Violence Found On The Internet, Erica Ann Pearson

Walden Dissertations and Doctoral Studies

Military domestic violence (MDV) is an issue in the United States. The purpose of this generic qualitative study was to explore how the mainstream media and published government content depicts MDV on the internet, and whether those narratives/video transcripts contained any agenda to generate influence. Ragas’ agenda-setting theory was used as a framework for this study. Agenda-setting is a communication specific phenomenon directed to influence individuals or organizations, based on what public relations practitioners present to the public. There are two research questions in this study. The first is: How do mainstream media narratives, and government documents depict survivors and …


Perceptions Of Coping Capacity And Burnout Among Psychiatric Social Workers, Akia Sheree Pittman Jan 2025

Perceptions Of Coping Capacity And Burnout Among Psychiatric Social Workers, Akia Sheree Pittman

Walden Dissertations and Doctoral Studies

U.S. mental health social workers practicing in psychiatric settings are susceptible to developing burnout. Burnout is a prominent and enduring social problem faced by many helping professionals, but especially among licensed mental health social workers. The purpose of this generic qualitative study was to explore the role coping capacity plays in mental health social workers developing burnout while employed in an inpatient psychiatric setting. The conceptual framework was sense of coherence, a core construct of the salutogenic theory of health. Data were collected from semistructured interviews with 10 clinical social workers employed in inpatient psychiatric settings in North Carolina. Data …


Preventing Burnout In Nursing Staff: Strategies And Best Practices For A Healthy Workplace, Friday Chidozie Nwabuisi Jan 2025

Preventing Burnout In Nursing Staff: Strategies And Best Practices For A Healthy Workplace, Friday Chidozie Nwabuisi

Walden Dissertations and Doctoral Studies

This doctoral project is a staff education initiative focused on improving nursing resilience and mental health through mindfulness-based interventions (MBIs). The project was informed by a practice-focused question: To what extent does the implementation of MBI training reduce stress and burnout among nursing staff in a clinical setting? The purpose of this project was to establish whether MBIs can be implemented as a support strategy in mitigating burnout and stress among nurses. The quantitative evaluation strategy used to determine the effectiveness of MBIs in reducing stress and burnout among nurses was a pretest and a posttest. The project targeted nursing …


Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica Jan 2025

Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica

Walden Dissertations and Doctoral Studies

Producing enough food to feed a growing human population without further degrading the environment through unsustainable natural resource use is a global issue. The purpose of this quantitative nonexperimental study was to examine the extent to which big data management of environmental impact sources, assessment methods, and allocation methods in multi-objective optimization (MOO) modeling affect the consistency and predictability of sustainable food animal feed management practices at the farm level. Representation theory, the theory of effective use of information systems, the dynamic capabilities view, and the natural resource-based view were used to describe the necessity of accurately representing and managing …


Clinical And Molecular Characteristics Of Patients With Brain Metastasis Secondary To Pancreatic Ductal Adenocarcinoma, Mahmoud Yousef, Mark W Hurd, Abdelrahman Yousef, Ethan B Ludmir, Ashwathy B Pillai, Jennifer Peterson, Eugene J Koay, Sali Albarouki, Ching-Wei Tzeng, Rebecca Snyder, Matthew H G Katz, Huamin Wang, Michael J Overman, Anirban Maitra, Shubham Pant, Brandon G Smaglo, Robert A Wolff, James Yao, John P Shen, Dan Zhao Jan 2025

Clinical And Molecular Characteristics Of Patients With Brain Metastasis Secondary To Pancreatic Ductal Adenocarcinoma, Mahmoud Yousef, Mark W Hurd, Abdelrahman Yousef, Ethan B Ludmir, Ashwathy B Pillai, Jennifer Peterson, Eugene J Koay, Sali Albarouki, Ching-Wei Tzeng, Rebecca Snyder, Matthew H G Katz, Huamin Wang, Michael J Overman, Anirban Maitra, Shubham Pant, Brandon G Smaglo, Robert A Wolff, James Yao, John P Shen, Dan Zhao

Faculty, Staff and Student Publications

Background: The prognosis for patients with pancreatic ductal adenocarcinoma (PDAC) is poor. Secondary brain metastasis (Br-M) occurs in less than 1% of patients. Clinical characteristics and molecular alterations have not been characterized in this rare patients' subset.

Materials and methods: The Foundry software platform was used to retrospectively query electronic health records for patients with Br-M secondary to PDAC from 2005 to 2023; clinical, molecular, and overall survival (OS) data were analyzed.

Results: Br-M was diagnosed in 44 patients with PDAC. Median follow-up was 78 months; median OS from initial PDAC diagnosis was 47 months. Median duration from PDAC diagnosis …


Prevalence Of High Tricuspid Regurgitation Jet Velocity In Patients With Sickle Cell Disease, Asaad Faisal Alkuheli, Meaad Kadhum Hassan, Jawad Atiya Jan 2025

Prevalence Of High Tricuspid Regurgitation Jet Velocity In Patients With Sickle Cell Disease, Asaad Faisal Alkuheli, Meaad Kadhum Hassan, Jawad Atiya

Iraqi National Journal of Medicine

Background: Elevated tricuspid regurgitation jet velocity (TRV) is a key indicator of pulmonary hypertension (PHT) in sickle cell disease (SCD) patients, with SCD occurring frequently in both adults and children. Aim: This study aimed to estimate TRV through echocardiography and assess the presence of comorbidities in SCD patients at the Center of Hereditary Blood Diseases. It further aimed to determine the percentage of elevated TRV and its relationship to various SCD-related variables. Methods: A cross-sectional, descriptive study was conducted to assess TRV in children and adolescents with SCD registered at the Center of Hereditary Blood Diseases from October 1, 2021 …


Targeting Trpc Channels For Control Of Arthritis-Induced Bone Erosion, Suravi Ray, Jamie L Mccall, Jin Bin Tian, Jaepyo Jeon, Aidan Douglas, Kendall Tyler, Siyao Liu, Kendyl Berry, Brady Nicewarner, Casey Hall, Klaus Groschner, Bernadett Bacsa, Werner Geldenhuys, Michael X Zhu, Harry C Blair, John B Barnett, Jonathan Soboloff Jan 2025

Targeting Trpc Channels For Control Of Arthritis-Induced Bone Erosion, Suravi Ray, Jamie L Mccall, Jin Bin Tian, Jaepyo Jeon, Aidan Douglas, Kendall Tyler, Siyao Liu, Kendyl Berry, Brady Nicewarner, Casey Hall, Klaus Groschner, Bernadett Bacsa, Werner Geldenhuys, Michael X Zhu, Harry C Blair, John B Barnett, Jonathan Soboloff

Faculty, Staff and Student Publications

Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca2+-selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the small-molecule ELP-004 preferentially inhibits transient receptor potential canonical (TRPC) channels. While ELP-004 minimally affected physiological RANKL-induced osteoclast maturation in murine bone marrow- and spleen-derived myeloid cells (BMSMCs) and human PBMC-derived cells, it potently interfered with osteoclast maturation driven by TNFα or LTB4. The contribution of TRPC channels to osteoclastogenesis was examined using BMSMCs derived from TRPC4-/- or TRPC(1-7)-/- mice, again revealing preferential interference with osteoclastogenesis driven …