Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 108451 - 108480 of 1737528

Full-Text Articles in Entire DC Network

Analyzing Organizational Commitment And Organizational Citizenship Behavior In Telecommuting Work Environments, Joshua L. Hays Jan 2025

Analyzing Organizational Commitment And Organizational Citizenship Behavior In Telecommuting Work Environments, Joshua L. Hays

Doctoral Dissertations and Projects

The COVID-19 pandemic forced employees and organizations into telecommuting roles which created undesirable consequences for the employee (distractions, overworking, isolation, etc.) and the organization (emotional disengagement, turnover, control, lack of collaboration, etc.). The research design for this study was a quasi-experimental correlational design to analyze the relationship between organizational commitment and telecommuting environments. The data obtained from the participants was collected by using Google Forms survey design. Upon receiving the required (n = 100) completed surveys, the data was then inputted into the Statistical Package for Social Sciences (SPSS) version 29 for analysis. The participants of this study were from …


Care Providers Caring For Military Members Struggling With Grief, Clara Altagracia García Jan 2025

Care Providers Caring For Military Members Struggling With Grief, Clara Altagracia García

Doctoral Dissertations and Projects

This research aims to address the lack of grief support services for service members (SMs) and veterans, which affects them and the wider community. The mission is to uncover the needs of SMs and veterans and devise effective strategies to support them. The literature review will provide the foundation for the need for research and create a reasonable solution for a healthier grieving process for SMs. This research aims to determine how complicated grief goes undetected and how counseling can help SMs and veterans. The thesis project will impact the grief counseling process of others in this field and bring …


William Bradford: An Unexpected Father Of Early Colonial American Politics, Megan E. Romero Jan 2025

William Bradford: An Unexpected Father Of Early Colonial American Politics, Megan E. Romero

Doctoral Dissertations and Projects

This dissertation is a project dedicated to explaining and defining not only who William Bradford was a person, but also as a leader to the people of Plymouth Colony and the Puritan faith. He was an individual who was dedicated to establishing a society that was fairer and more equal for all people, who could have the chance to grow economically, practice their faith freely, and live a more politically stable life. Through research conducted on Bradford’s life, it became easier to understand that due to his determination and hard work he quickly rose up in the ranks and perspectives …


Technology-As-Instrument: A Case Study Of Undergraduate Student Experience With Daw Technology, Brian Coski Jan 2025

Technology-As-Instrument: A Case Study Of Undergraduate Student Experience With Daw Technology, Brian Coski

Doctoral Dissertations and Projects

Within the typical music appreciation class, diverse subsections of students exhibit varying levels of experience that can result in challenging inequities in engagement and comprehension. For those students with no background in playing an instrument or singing, musical ideas often need more context and perspective. Technology can present an opportunity for all students to explore the elements of music by utilizing music production software as a virtual instrument. In this study, the researcher utilized curriculum strategies specifically designed to foster deep musical connection through a technology-as-instrument approach. Through informal learning and the tools of music production, students visualized and interacted …


Caring For Ukrainian Healthcare Professionals In Wartime: Moral Injury And Psycho-Spiritual Intervention, Rodger L. Stenger Jan 2025

Caring For Ukrainian Healthcare Professionals In Wartime: Moral Injury And Psycho-Spiritual Intervention, Rodger L. Stenger

Doctoral Dissertations and Projects

This mixed-methods study examined the prevalence of Moral Injury (MI) among Ukrainian healthcare professionals (UHCPs) and their willingness to engage in evidence-based, psycho-spiritual interventions targeting MI that has resulted from the Russian invasion and the COVID-19 pandemic. MI is a psychological construct resulting from actions that violate an individual’s moral code and can overlap with Post Traumatic Stress Disorder (PTSD) symptoms. While MI has been extensively researched in the military, it has gained attention in healthcare settings. Utilizing the Moral Injury Symptom Scale-Healthcare Professional (MISS-HP), this study quantitatively identified a moderate prevalence of MI among doctors and nurses in Ukraine. …


Halogeton And Greasewood Poisoning In Cattle And Sheep In Utah, E. Jane Kelly, Stephen T. Lee, Ammon Brown, Daniel Cook Jan 2025

Halogeton And Greasewood Poisoning In Cattle And Sheep In Utah, E. Jane Kelly, Stephen T. Lee, Ammon Brown, Daniel Cook

Poisonous Plant Research (PPR)

Halogeton (Halogeton glomeratus) is a fast-growing annual plant while greasewood (Sarcobatus vermiculatus) is a perennial shrub of the Western States. Oxalates are the toxic principle in halogeton and greasewood. Most losses occur when hungry animals are allowed to graze in heavy stands of halogeton and greasewood. Halogeton and greasewood are always dangerous and become more toxic as the growing season progresses. Here we report on two clinical cases of halogeton and greasewood poisoning in cattle and sheep. Histologically, oxalate crystals were observed in the kidneys of the cow and sheep consistent with oxalate poisoning. Oxalate was …


Refurbishing Used Gps Transmitters Improves Performance For Subsequent Deployments On Greater Sage-Grouse, Melissa S. Chelak, Michel T. Kohl, Justin R. Small, Kurt T. Smith, Aaron C. Pratt, Jeffrey L. Beck, Codi R. Backen, M. Brandon Flack, Hailey P. Wayment, Jason A. Wood, Ryan Howell, Trevon D. Strange, Lucian R. Mcdonald, Kezia R. Manlove, Shandra N. Frey, Randy T. Larsen, Brian A. Maxfield, David K. Dahlgren, Terry A. Messmer, David C. Stoner Jan 2025

Refurbishing Used Gps Transmitters Improves Performance For Subsequent Deployments On Greater Sage-Grouse, Melissa S. Chelak, Michel T. Kohl, Justin R. Small, Kurt T. Smith, Aaron C. Pratt, Jeffrey L. Beck, Codi R. Backen, M. Brandon Flack, Hailey P. Wayment, Jason A. Wood, Ryan Howell, Trevon D. Strange, Lucian R. Mcdonald, Kezia R. Manlove, Shandra N. Frey, Randy T. Larsen, Brian A. Maxfield, David K. Dahlgren, Terry A. Messmer, David C. Stoner

Wildland Resources Student Research

Global Positioning Systems (GPS) radio transmitters are increasingly used across taxa to monitor animal populations. However, GPS transmitters can be susceptible to malfunctions that may result in location errors or data loss causing potential inferential bias that can have important implications for monitored species. Research using GPS transmitters on greater sage-grouse (Centrocercus urophasianus; sage-grouse) has increased, but few sage-grouse studies have evaluated GPS performance. Because sage-grouse management has been subject to intense legal and political scrutiny with consequential economic implications, reliable data acquisition is central to informed decision-making for the species. We evaluated differences in the performance of …


Reflections On The Belfast/Good Friday Agreement, Alina Gamboa Combs Jan 2025

Reflections On The Belfast/Good Friday Agreement, Alina Gamboa Combs

Journal of Critical Global Issues

The 1998 Belfast Agreement, also known as the Good Friday Agreement (B/GFA), is considered a milestone for brokering peace and moving forward past the period known as the “Troubles” that plagued Northern Ireland for three decades (1961-1994). An overwhelming majority: 71 percent of the electorate in Northern Ireland (81 percent voter turnout) voted yes to the question, “Do you support the Agreement reached in the Multi-Party Talks?” giving the B/GFA and the subsequent legally binding British-Irish Agreement (BIA) strong public support. Since its signing, the B/GFA has been implemented in part. A key component, forming a Northern Ireland Assembly and …


What Hath Jerusalem To Do With Chile: Towards An Evangelical Understanding Of The Enneagram And Its Usage For Spiritual Development, Wesley E. Scholtz Jan 2025

What Hath Jerusalem To Do With Chile: Towards An Evangelical Understanding Of The Enneagram And Its Usage For Spiritual Development, Wesley E. Scholtz

Doctoral Dissertations and Projects

Currently, it is estimated that the personality testing market is worth approximately $2 billion. The Church has expressed interest in understanding personality types through various testing methods. The Enneagram offers a possibly ancient method to help people understand who they are in a spiritual capacity, which can be an aid in connecting more closely with God. This dissertation addressed the research gap that exists within the current literature which is the lack of data concerning whether adults who are professional, ordained ministers are aware of, use, and may be skeptical of the Enneagram. The research method in this dissertation was …


An Educational Intervention Focused On The Importance Of Follow-Up Appointments For Telehealth Patients, Stella Chizoma Emerenini Jan 2025

An Educational Intervention Focused On The Importance Of Follow-Up Appointments For Telehealth Patients, Stella Chizoma Emerenini

Walden Dissertations and Doctoral Studies

my


Arguments For The Sovereignty Of God In The Book Of Job, Elizabeth J. Welch Jan 2025

Arguments For The Sovereignty Of God In The Book Of Job, Elizabeth J. Welch

Doctoral Dissertations and Projects

The book of Job is a complex piece of wisdom literature studied for centuries using various methodologies to elucidate theological doctrines, biblical themes, and literary motifs. This dissertation aims to demonstrate that a midrashic form of exposition significantly expands the understanding of the Joban arguments for and against the sovereignty of God within the context of the ancient views of divine retribution and human suffering. Encapsulated in the legal motif, the disclosure and discussion of these views with associated themes, such as theocracy, theodicy, justice, and theophany, identified God’s sovereignty as the most prevalent doctrine in the book. The three …


Impact Of Transformational Leadership On Job Satisfaction Among Staff In Private Child Care Agencies, Carmin Marie Johnson Jan 2025

Impact Of Transformational Leadership On Job Satisfaction Among Staff In Private Child Care Agencies, Carmin Marie Johnson

Online Theses and Dissertations

Leadership styles and behaviors can impact employees' job performance and satisfaction. Murari and Mukherjee (2021), highlight that “building trust, clear vision, intellectual stimulation, inspirational motivation, self-awareness, transparency, individualized consideration, wisdom and knowledge, and congruent values” (p. 3612); are the faces of transformational leadership. Positive or negative behaviors can significantly affect job performance and total job satisfaction. The behavior of leadership has a significant impact on the success of employees and organizations. Leadership behavior affects many organizations, such as schools, community organizations, governmental organizations, and private agencies. Creswell (2012) describes correlational design as a form of research that uses data analysis …


Racial Disparities Of Type 2 Diabetes Through Exercise: The Multi-Ethnic Study Of Atherosclerosis, Tong Xia, Roch A. Nianogo, Qingzhao Yu, Tamara Horwich, Preethi Srikanthan, Kosuke Inoue, Matthew Allison, Zuo-Feng Zhang, Karol E. Watson, Liwei Chen Jan 2025

Racial Disparities Of Type 2 Diabetes Through Exercise: The Multi-Ethnic Study Of Atherosclerosis, Tong Xia, Roch A. Nianogo, Qingzhao Yu, Tamara Horwich, Preethi Srikanthan, Kosuke Inoue, Matthew Allison, Zuo-Feng Zhang, Karol E. Watson, Liwei Chen

School of Public Health Faculty Publications

Introduction: Persistent racial and ethnic disparities exist for Type 2 diabetes in the U.S. Racial and ethnic minorities have a higher risk of Type 2 diabetes, and studies suggest that they engage in less exercise than White population. This study examined whether and to what degree racial differences in Type 2 diabetes were explained by exercise. Methods: Adults aged 45–84 years without Type 2 diabetes at baseline (2000–2002) were included from the Multi-Ethnic Study of Atherosclerosis cohort and followed through 2020. Associations between race and Type 2 diabetes were examined using multivariable Cox proportional hazard regression. The effects of exercise …


Theological Themes And Musical Influences Of Worship In Indonesian Immigrant Churches In The United States, Agnes Keren Bale Jan 2025

Theological Themes And Musical Influences Of Worship In Indonesian Immigrant Churches In The United States, Agnes Keren Bale

Masters Theses

Beyond evoking emotional experience, theologically sound songs are crucial for evangelizing, edifying the church, and congregational spiritual growth. This study examines worship in Indonesian immigrant churches in the United States, analyzing recurring theological themes in the most regularly featured songs in the worship repertoire. Additionally, it explores the influence of Western worship music which shapes the blended identity of these churches. Via the data gathered through worship service observations from a few churches and a survey for platform ministers, twenty-two congregational songs were coded and analyzed for their theological themes. Findings included the omnipotence and sovereignty of God, victory/battle, faith, …


The Positive Effects Of Audience Participation In Classic Literature, Joyelle Davis Braggs Jan 2025

The Positive Effects Of Audience Participation In Classic Literature, Joyelle Davis Braggs

Masters Theses

My thesis reviews the history of fan-fiction and how it plays a role in the world of literature, specifically classic literature. It focuses on Jane Eyre and Charlotte Bronte as well as the reasons why that storyline concluded the way it did. Also, I review the reasons why fans have decided to write their own versions of stories to either refresh or renew a character or storyline.

There is a brief history of fan-fiction and a simple summary of Jane Eyre. Included are examples of fan fiction that faced legal challenges both successfully and unsuccessfully. I have also shared my …


Witchcraft, Demons, And Spiritual Death: An Apologetic For The Bible's Prohibition Against Witchcraft, Joshua Dean Wrenn Jan 2025

Witchcraft, Demons, And Spiritual Death: An Apologetic For The Bible's Prohibition Against Witchcraft, Joshua Dean Wrenn

Masters Theses

This paper attempts to apologetically defend the Bible's intolerance against witchcraft and other related activities that are prohibited in the Old Testament. It does so by showing that Witchcraft and other related activities gets one involved with demonic entities. It shows how demonic entities are deceitful, and how they are actually the ones behind the power of witchcraft. The paper starts by studying the history of ancient witchcraft, which is something that is useful for understanding the witchcraft of today. It then builds a profile of demons. The paper shows what demons physically do and what they attempt to get …


The Pragmatic Effect Of Φιλέω And Αγαπάω In John 21:15-17, Steven J. P'Pool Jan 2025

The Pragmatic Effect Of Φιλέω And Αγαπάω In John 21:15-17, Steven J. P'Pool

Masters Theses

The final chapter of John’s gospel is central to the New Testament in that it depicts the risen Jesus appearing to His disciples and sharing a meal with them, restoring Peter to his place as a leader among his brothers, and records John’s eyewitness testimony to the events reported. It is in verses fifteen through seventeen of chapter twenty-one that attention turns to Peter and John, with the latter eaves dropping on the conversation. John records the conversation in these three verses in which Jesus restores Peter from his trio of denials prior to Jesus’ crucifixion with three opportunities for …


Chemical Emergency Preparedness: Chempack & Its Contents, Grace Feigl Jan 2025

Chemical Emergency Preparedness: Chempack & Its Contents, Grace Feigl

All Other Contributions

No abstract provided.


In Touch With Those In Need: How Touchscreen Devices Lead Consumers To Support Social Causes, Aekyoung Kim, Hyojin Lee, Saerom Lee Jan 2025

In Touch With Those In Need: How Touchscreen Devices Lead Consumers To Support Social Causes, Aekyoung Kim, Hyojin Lee, Saerom Lee

Faculty Research, Scholarly, and Creative Activity

As consumers are increasingly using touchscreen devices (e.g., tablets or smartphones) when exposed to various marketing messages, this research explores how touchscreen devices alter consumer reactions to social cause marketing. This research shows that using touchscreen (vs. nontouchscreen) devices while viewing online charity ads featuring human victims increases consumers’ support for the advertised social causes. Four studies demonstrate this effect by examining consumers’ social media activities, donation intentions, and actual donations in field and lab settings. Mediation analysis reveals that using touchscreen (vs. nontouchscreen) devices enhances consumer support through increased empathy for the victims featured in charity ads. Together, this …


Snora37/Cmtr1/Elavl1 Feedback Loop Drives Gastric Cancer Progression Via Facilitating Cd44 Alternative Splicing, Banghe Bao, Minxiu Tian, Xiaojing Wang, Chunhui Yang, Jiaying Qu, Shunchen Zhou, Yang Cheng, Qiangsong Tong, Liduan Zheng Jan 2025

Snora37/Cmtr1/Elavl1 Feedback Loop Drives Gastric Cancer Progression Via Facilitating Cd44 Alternative Splicing, Banghe Bao, Minxiu Tian, Xiaojing Wang, Chunhui Yang, Jiaying Qu, Shunchen Zhou, Yang Cheng, Qiangsong Tong, Liduan Zheng

Faculty, Staff and Students Publications

Background: Emerging evidence shows that small nucleolar RNA (snoRNA), a type of highly conserved non-coding RNA, is involved in tumorigenesis and aggressiveness. However, the roles of snoRNAs in regulating alternative splicing crucial for cancer progression remain elusive.

Methods: High-throughput RNA sequencing and comprehensive analysis were performed to identify crucial snoRNAs and downstream alternative splicing events. Biotin-labeled RNA pull-down, mass spectrometry, cross-linking RNA immunoprecipitation, and in vitro binding assays were applied to explore interaction of snoRNAs with protein partners. Alternative splicing and gene expression was observed by real-time quantitative RT-PCR and western blot assays. In vitro and in vivo studies were …


Atrial Fibrillation Recurrence Risk After Catheter Ablation In Patients With Rheumatoid Arthritis: A Systematic Review And Meta-Analysis, Pongprueth Rujirachun, Phuuwadith Wattanachayakul, Svita Taveeamornrat, Patompong Ungprasert, Nithi Tokavanich, Krit Jongnarangsin Jan 2025

Atrial Fibrillation Recurrence Risk After Catheter Ablation In Patients With Rheumatoid Arthritis: A Systematic Review And Meta-Analysis, Pongprueth Rujirachun, Phuuwadith Wattanachayakul, Svita Taveeamornrat, Patompong Ungprasert, Nithi Tokavanich, Krit Jongnarangsin

Einstein Health Papers

BACKGROUND: The association between rheumatoid arthritis (RA) and the risk of developing atrial fibrillation (AF) is well-established. However, data on the impact of RA on AF recurrence postcatheter ablation (CA) remain unclear. This current study aimed to assess the impact of RA on AF recurrence after catheter-based pulmonary vein isolation.

METHODS: Potentially eligible studies were identified from Medline and EMBASE databases from inception to December 20, 2023. Eligible study must consist of two cohorts of patients with and without RA who underwent catheter ablation for AF. Pooled risk ratio (RR) and 95% CI were calculated using Dersimonian and Laird's random-effect, …


Expansion Of Genotypic And Phenotypic Findings In Adamts18-Related Ocular Pathology, Ari August, Rebecca Procopio, Christopher Rapuano, Jose Pulido Jan 2025

Expansion Of Genotypic And Phenotypic Findings In Adamts18-Related Ocular Pathology, Ari August, Rebecca Procopio, Christopher Rapuano, Jose Pulido

Wills Eye Hospital Papers

Purpose: ADAMTS18-related ocular pathology is rare with few described cases. Features include distinctive facies, refractive error, anterior segment dysgenesis, and retinal dystrophy. Previous patients were found to have ho- mozygous variants in ADAMTS18. Here, we present a patient with compound heterozygous ADAMTS18-related pathology and its associated findings. Observations: A 37-year-old male with a history of bilateral congenital nasolacrimal duct obstruction, dry eye syndrome, mild myopia, and accommodative esotropia presented to the Retina Service. He was found to have multiple features of anterior segment dysgenesis and retinal dystrophy, some of which have not been previously reported in association with ADAMTS18 variants. …


Exploring The Pathogen Profiles Of Ancient Feces, Drew Capone, David Holcomb, Amanda Lai, Karl Reinhard, Joe Brown Jan 2025

Exploring The Pathogen Profiles Of Ancient Feces, Drew Capone, David Holcomb, Amanda Lai, Karl Reinhard, Joe Brown

Karl Reinhard Publications

Analysis of ancient desiccated feces – termed paleofeces or coprolites – can unlock insights into the lives of ancient people. We collected desiccated feces from caves in the Rio Zape Valley in Mexico (725-920 CE). First, we extracted DNA with methods previously optimized for paleofeces. Then, we applied highly sensitive modern molecular tools (i.e., PCR pre-amplification followed by multi-parallel qPCR) to assess the presence of 30 enteric pathogens. We detected ≥1 pathogen associated gene in each of the ten samples and a mean of 3.9 pathogens per sample. The targets detected included Blastocystis spp. (n=7), atypical enteropathogenic E. coli (n=7), …


Assessment, Decision, Adaptation, Production, Topical Experts-Integration, Training, And Testing (Adapt-Itt) Framework To Tailor Evidence-Based Posttraumatic Stress Disorder Treatment For People With Hiv To Enhance Engagement And Adherence: Qualitative Results From A Feasibility Randomized Controlled Trial, Cristina M. Lopez, Angela D. Moreland, Stephanie Amaya, Erin Bisca, Christin Mujica, Tayler Wilson, Nathaniel Baker, Lauren Richey, Allison Ross Eckard, Patricia A. Resick, Steven A. Safren, Carla Kmett Danielson Jan 2025

Assessment, Decision, Adaptation, Production, Topical Experts-Integration, Training, And Testing (Adapt-Itt) Framework To Tailor Evidence-Based Posttraumatic Stress Disorder Treatment For People With Hiv To Enhance Engagement And Adherence: Qualitative Results From A Feasibility Randomized Controlled Trial, Cristina M. Lopez, Angela D. Moreland, Stephanie Amaya, Erin Bisca, Christin Mujica, Tayler Wilson, Nathaniel Baker, Lauren Richey, Allison Ross Eckard, Patricia A. Resick, Steven A. Safren, Carla Kmett Danielson

School of Medicine Faculty Publications

BACKGROUND: Individuals with co-occurring posttraumatic stress disorder (PTSD) and HIV are at high-risk for negative HIV-related outcomes, including low adherence to antiretroviral therapy, faster disease progression, more hospitalizations, and almost twice the rate of death. Despite high rates of PTSD in persons with HIV (PWH) and poor HIV-related health outcomes associated with PTSD, an effective evidence-based treatment for PTSD symptoms in PWH does not exist. OBJECTIVE: This study aimed to describe the adaptation and theater testing of an evidence-based intervention designed for people with co-occurring PTSD and HIV. METHODS: The Assessment, Decision, Adaptation, Production, Topical experts-integration, Training, and Testing (ADAPT-ITT) …


Using Implementation Mapping To Design An Implementation Strategy For Classroom-Based Physical Activity Approaches In Elementary Schools, Timothy J Walker, Derek W Craig, Christopher D Pfledderer, Kempson Onadeko, Emma E Saving, Hildi M Nicksic, Krista Patlovich, Keisey Fumero, John B Bartholomew, Maria E Fernández Jan 2025

Using Implementation Mapping To Design An Implementation Strategy For Classroom-Based Physical Activity Approaches In Elementary Schools, Timothy J Walker, Derek W Craig, Christopher D Pfledderer, Kempson Onadeko, Emma E Saving, Hildi M Nicksic, Krista Patlovich, Keisey Fumero, John B Bartholomew, Maria E Fernández

Faculty, Staff and Student Publications

Background: Physically active breaks and lessons are evidence-based approaches to improving student's physical activity. Yet, schools and teachers face implementation challenges, requiring the need for effective implementation strategies.

Purpose: Use Implementation Mapping to develop an implementation strategy for physically active breaks and lessons in elementary schools.

Methods: With our partner school district, we assembled a planning group with expertise in education, public health, and implementation science. The group completed five Implementation Mapping tasks: (i) conduct needs and assets assessment and identify adopters and implementers, (ii) identify implementation outcomes, performance objectives, and determinants, and create matrices of change objectives, (iii) choose …


An Educational Intervention Focused On The Importance Of Follow-Up Appointments For Telehealth Patients, Stella Chizoma Emerenini Jan 2025

An Educational Intervention Focused On The Importance Of Follow-Up Appointments For Telehealth Patients, Stella Chizoma Emerenini

Walden Dissertations and Doctoral Studies

my


Associations Between Deficit Accumulation Frailty And Baseline Markers Of Lifestyle In The Us Pointer Trial, Mark A Espeland, Yitbarek N Demesie, Kayloni Olson, Samuel N Lockhart, Sarah E Tomaszewski Farias, Maryjo L Cleveland, Christy C Tangney, Lucia Crivelli, Heather M Snyder, Michele K York, Laura D Baker, Rachel A Whitmer, Rena R Wing, Katelyn R Garcia, Kathryn E Callahan Jan 2025

Associations Between Deficit Accumulation Frailty And Baseline Markers Of Lifestyle In The Us Pointer Trial, Mark A Espeland, Yitbarek N Demesie, Kayloni Olson, Samuel N Lockhart, Sarah E Tomaszewski Farias, Maryjo L Cleveland, Christy C Tangney, Lucia Crivelli, Heather M Snyder, Michele K York, Laura D Baker, Rachel A Whitmer, Rena R Wing, Katelyn R Garcia, Kathryn E Callahan

Faculty, Staff and Students Publications

BACKGROUND: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty index developed by the U.S. POINTER clinical trial team of investigators and assess its cross-sectional associations with sociodemographic factors and markers chosen to be representative of behaviors targeted by the trial's multidomain interventions.

METHODS: We draw baseline data from the 2 111 volunteers enrolled in U.S. POINTER who were ages 60-79 years and at increased risk for cognitive decline. Frailty components were grouped into 9 domains. Associations that frailty index scores …


Sex Differences In Response To Diet Enriched With Glutathione Precursors In The Aging Heart, Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, Joann Trial, George E Taffet, Katarzyna A Cieslik Jan 2025

Sex Differences In Response To Diet Enriched With Glutathione Precursors In The Aging Heart, Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, Joann Trial, George E Taffet, Katarzyna A Cieslik

Faculty, Staff and Students Publications

Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed glycine and N-acetyl cysteine (GlyNAC; glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, and the exercise performance was determined at the end of the study. We found that the GlyNAC diet was beneficial for old male but not old female mice, leading to an increase of Ndufb8 expression (a …


The Simca Study Protocol: Factors Influencing The Implementation Of The Midwifery Continuity Of Carer (Mcoc) Model Of Care In Nhs Maternity Care In England: A Mixed Methods Cross Case Analysis Involving Clinicians, Women And Policy Makers, Rebecca Milton, Susan Channon, Julia Sanders, Sara Kenyon, Aimee Middlemiss, Heather Strange, Kate Davies, Lena Choudary-Salter, Susan Barry, Tina Prendeville, Aled Jones Jan 2025

The Simca Study Protocol: Factors Influencing The Implementation Of The Midwifery Continuity Of Carer (Mcoc) Model Of Care In Nhs Maternity Care In England: A Mixed Methods Cross Case Analysis Involving Clinicians, Women And Policy Makers, Rebecca Milton, Susan Channon, Julia Sanders, Sara Kenyon, Aimee Middlemiss, Heather Strange, Kate Davies, Lena Choudary-Salter, Susan Barry, Tina Prendeville, Aled Jones

School of Nursing and Midwifery

Background: During pregnancy, labour and early motherhood, most women in the UK receive care from different midwives. NHS policy change in England sought to introduce a model of care whereby each woman is cared for by the same midwife throughout antenatal, intrapartum and postnatal periods, supported by a small team of midwives to cover off-duty periods. This model is called the Midwifery Continuity of Carer (MCoC). This study proposes to evaluate the implementation and delivery of MCoC across England, aiming to better understand the factors that result in different rates of progress with MCoC implementation. Aim: To identify the local, …


Phase I Study Of Bms-986299, An Nlrp3 Agonist, As Monotherapy And In Combination With Nivolumab And Ipilimumab In Patients With Advanced Solid Tumors, Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick Mckinley, Ruslan D Novosiadly, Sarina A Piha-Paul Jan 2025

Phase I Study Of Bms-986299, An Nlrp3 Agonist, As Monotherapy And In Combination With Nivolumab And Ipilimumab In Patients With Advanced Solid Tumors, Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick Mckinley, Ruslan D Novosiadly, Sarina A Piha-Paul

Faculty, Staff and Student Publications

Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.

Materials and methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.

Results: 36 patients were enrolled, with breast (31%), colorectal (17%), and head and neck (14%) being the more commonly enrolled cancers. Most patients (58%) had received prior immunotherapy. Therapy was well-tolerated, with G1-G2 fever (70%), neutrophilia (36%), and leukocytosis …