Digital Commons Network^™

In Silico Analysis Of Cd40 Mutations And Their Implications For Quinoline-Benzoic Acid Derivatives Based Therapy In Graves' Disease, Luluk Yunaini, Diyah Kristanty, Puji Sari, Surya Dwira, Dwi Anita Suryandari, Arleni Bustami

Indonesian Journal of Medical Chemistry and Bioinformatics

Graves' disease is an autoimmune disorder in which the CD40-CD154 interaction plays a critical role in T-cell activation. In this study, in silico methods were employed to analyze the binding interactions of quinoline-benzoic acid derivatives (NSB, FSB, and NQB) with the CD40 receptor and to investigate the implications of specific CD40 mutations for drug efficacy. In this reseach conducted by molecular simulation approach with molecular docking Results Mutation analysis of CD40 identified alterations in key residues, such as R203C, which may impact ligand-independent activation and downstream TRAF binding, crucial for signal transduction. These findings highlight the therapeutic potential of quinoline-benzoic …

Leveraging Ai For Early Detection Of Anxiety And Depression In The Emergency Department: Improving Patient Outcomes Through Screening, Sofia Pfannenbecker, Ayushi Sinha, Michael A. Friedman, Sydney N. Chapman, Molly R. Ruttenberg, Aditya Loganathan, Nicholas Melucci

URGENT Matters

No abstract provided.

When The Rich Do (Not) Trust The (Newly) Rich: Experimental Evidence On The Effects Of Positive Random Shocks In The Trust Game, Hernán Bejarano, Joris Gillet, Ismael Rodriguez-Lara

ESI Publications

We study behavior in a trust game where first-movers initially have a higher endowment than second-movers but the occurrence of a positive random shock can eliminate this inequality by increasing the endowment of the second-mover before the decision of the first-mover. We find that second-movers return less (i.e., they are less trustworthy) when they have a lower endowment than first-movers, compared with the case in which first and second-movers have the same endowment. In addition, second-movers who experience the positive shock return more than second-movers who have the same endowment as the first-mover from the outset. First-movers do not seem …

Salinity Does Not Affect Late-Stage In-Egg Embryonic Or Immediate Post-Hatch Development In An Ecologically Important Land Crab Species, Lucy M. Turner, Katharine A. Clayton, Linn Wiberg, Charlotte H. Wilson, Ziad Ibbini, Oliver Tills, John I. Spicer

School of Biological and Marine Sciences

Environmental drivers such as salinity can impact the timing and duration of developmental events in aquatic early life stages of crustaceans, including terrestrial crabs of the family Gecarcinidae. Low salinity delays larval development in land crabs, but nothing is known about its influence on the crucial late-stage encapsulated embryonic or immediate post-hatch development. Therefore, we exposed fertilised late-stage embryos of the Christmas Island red crab (Gecarcoidea natalis) to differing salinities (100%, 75%, 50% or 25% sea water) for 24 h during their spawning period and measured some key developmental and physiological traits. We found no effect of salinity on time …

Simulations Of Attosecond Metallization In Quartz And Diamond Probed With Inner-Shell Transient Absorption Spectroscopy, Lucas Kurkowski, Adonay Sissay, Mengqi Yang, Alexander Meyer, Kenneth Lopata

Faculty Publications

When dielectrics are hit with intense infrared (IR) laser pulses, transient metalization can occur. The initial attosecond dynamics behind this metallization are not entirely understood. Therefore, simulations are needed to understand this process and to help interpret experimental observations of it, such as with attosecond transient absorption (ATA). In this paper, we present first-principles simulations of ATA based on bulk-mimicking clusters and real-time time-dependent density functional theory (RT-TDDFT), with Koopmans-tuned range-separated hybrid functionals and Gaussian basis sets. Our method gives good agreement with the experiment for the breakdown threshold in silica and diamond. This breakdown voltage corresponds to a Keldysh …

Faculty Recital | Elizabeth Johnson Knight, Mezzo-Soprano And Eric Jenkins, Piano

Bailey School of Music Concert Programs

Elizabeth Johnson Knight, Mezzo-Soprano

Eric Jenkins, Piano

Self-Regulation: Skill Development Framework, Claire Scoular, Ian Teo, Jonathan Heard, Adam Wardell

Assessment and Reporting

This self-regulation skill development framework was developed to address the challenges associated with teaching and assessing self-regulation. It provides a general definition of self-regulation and describes this construct as it applies in classroom-based learning. This framework synthesises and harmonises existing theory and research on self-regulation. It outlines self-regulation processes along prescribed strands and aspects that are informed by evidence. The strands contained within the framework are 1. Cognitive regulating; 2. Behavioural regulating; and 3. Emotional regulating. The strands are further broken down into aspects to inform teaching and assessment.

Wayne Ford Racial Impact Statement Act And The Necessity Of Minority Impact Statements, Seonwoo Kim

Cardozo Journal of Equal Rights and Social Justice (ERSJ) Blog

In 1968, Congress passed the Anti-Drug Abuse Act (“ADAA”) in response to the drug overdose of Len Bias, a basketball star at the University of Maryland.  The Act imposed harsh sentences for crack cocaine offenses; a person charged with possession of crack cocaine faced the same mandatory minimum prison sentence as someone charged with possession of one hundred times more powered cocaine.  For example, a person charged with carrying five grams of crack cocaine would receive the same sentence as someone carrying five hundred grams of powdered cocaine. Historically, the enforcement of drug-related crimes disproportionately targeted Black Americans, and this …

Fairs - A Framework For Evaluating The Inclusion Of Sex In Clinical Algorithms, Katherine E Goodman, Jennifer Blumenthal-Barby, Rita F Redberg, Diane E Hoffmann

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

The Biological Intersection Between Chemotherapy-Related Cognitive Impairment And Alzheimer Disease, Matthew Torre, Camila A Zanella, Mel B Feany

Duncan NRI Faculty and Staff Publications

Alzheimer disease (AD) is the most common type of dementia and one of the leading causes of death in elderly patients. The number of patients with AD in the United States is projected to double by 2060. Thus, understanding modifiable risk factors for AD is an urgent public health priority. In parallel with the number of patients with AD, the number of cancer survivors is estimated to increase significantly, and up to 80% of cancer patients treated with chemotherapy will develop cognitive deficits, termed chemotherapy-related cognitive impairment. This review discusses biologically plausible pathways underlying both disorders, with the goal of …

A Global Dataset Of Nitrogen Fixation Rates Across Inland And Coastal Waters, Robinson W. Fulweiler, Megan E. Berberich, Shelby A. Rinehart, Jason M. Taylor, Michelle Catherine Kelly, Nicholas E. Ray, Autumn Oczkowski, Sawyer J. Balint, Alexandra H. Geisser, Catherine R. Mahoney, Mar Benavides, Matthew J. Church, Brianna Loeks, Silvia E. Newell, Malin Olofsson, Jimmy C. Oppong, Sarah S. Roley, Carmella Vizza, Samuel T. Wilson, Peter M. Groffman, J. Thad Scott, Amy Marcarelli

Michigan Tech Publications

Biological nitrogen fixation is the conversion of dinitrogen (N2) gas into bioavailable nitrogen by microorganisms with consequences for primary production, ecosystem function, and global climate. Here we present a compiled dataset of 4793 nitrogen fixation (N2-fixation) rates measured in the water column and benthos of inland and coastal systems via the acetylene reduction assay, 15N2 labeling, or N2/Ar technique. While the data are distributed across seven continents, most observations (88%) are from the northern hemisphere. 15N2 labeling accounted for 67% of water column measurements, while the acetylene reduction assay accounted for 81% of benthic N2-fixation observations. Dataset median area-, volume-, …

Concordia Seminary Magazine Fall/Winter 2024, Vicki Biggs

Concordia Seminary Magazine

Let us Fix Our Eyes on Jesus

Diasporic Trans/Forming In Diriye Osman's The Butterfly Jungle, Afdhere Jama's Being Queer And Somali, Tofik Dibi's Djinn And Lamya H'S Hijab Butch Blues, John C. Hawley

English

Queer East African writers like Diriye Osman and Afdhere Jama instantiate Christopher Ian Foster’s 2019 assertion that ‘neoliberal globalization and the management of movement— immigration—cannot be disentangled from heteronationalist discourses’. The criticism that one read years ago, and still reads, that the gay and lesbian “lifestyle” is a Western imposition on African identities, and that those Africans who espouse such identities for themselves are inherently un-African or even anti-African, is now ensconced in the laws of many African nations, making it dangerous to remain in one’s native land if one expresses—publicly—a sexuality that is non-normative or non-binary. The former is …

Communication: Skill Development Framework, Claire Scoular, Jonathan Heard, Adam Wardell

Assessment and Reporting

This communication skill development framework was developed to address the challenges associated with teaching and assessing communication. It provides a general definition of communication and describes this construct as it applies in classroom-based learning. This framework synthesises and harmonises existing theory and research on communication. It outlines communication processes along prescribed strands and aspects that are informed by evidence. The strands contained within the framework are 1. Strategising an approach; 2. Conveying information; and 3. Receiving communication. The strands are further broken down into aspects to inform teaching and assessment.

Development And Validation Of Rapid Edna Detection Method For Yellow Mud Turtle, Kinosternon Flavescens: A Field Study In South Texas, Usa, Sakib Tahmid Rishan, Richard Kline, Md Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

The conservation of freshwater turtle species depends on precise and effective monitoring techniques. Environmental DNA (eDNA) analysis is a potential method for identifying cryptic and elusive turtle species in aquatic ecosystems. eDNA analysis can help to identify key regions for conservation efforts and monitor changes in population levels over time. This study aims to evaluate the effectiveness of a rapid eDNA detection method for the yellow mud turtle (Kinosternon flavescens, an indicator species that is endangered in some states in the USA), which inhabits local oxbow lakes (e.g., resacas) in Cameron County, South Texas. A species-specific nested PCR …

The Cowl - V. 88 N. 11 - January 23, 2025

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 11 - January 23, 2025. 20 pages.

Computing Education In African Countries: A Literature Review And Contextualised Learning Materials, Sally Hamouda, Linda Marshall, Kate Sanders, Ethel Tshukudu, Oluwatoyin Adelakun-Adeyemo, Brett A. Becker, Emma R. Dodoo, G. Ayorkor Korsah, Sandani Luvhengo, Oluwakemi Ola, Jack Parkinson, Ismaila Temitayo Sanusi

Faculty Research, Scholarly, and Creative Activity

This report begins with a literature review of computing education in Africa. We found a substantial body of work, scattered over more than 80 venues, which we have brought together here for the first time. Several important themes emerge in this dataset, including the need to contextualise computing education. In the second part of this report we investigate contextualisation further. We present a pilot study, grounded in the literature review, of the development of course materials, sample code, and programming assignments for introductory programming, contextualised for six African countries: Botswana, Egypt, Ghana, Nigeria, South Africa, and Zambia. We include the …

Synergistic Effects Of Extra X Chromosome On Development Of Systemic Lupus Erythematosus And Sjögren Disease In Klinefelter And Triple X Syndrome: A Retrospective Cohort Study, Anna-Kay Palmer, Irene J. Tan

Einstein Health Papers

OBJECTIVE: Systemic lupus erythematosus (SLE) and Sjögren disease (SjD) are autoimmune diseases with significant female predominance. The prevalence of SLE is increased in Klinefelter syndrome (KS) compared with the general male population. Our study investigates the dose effects of extra X chromosomes on the development of SLE and SjD in KS and triple X syndrome compared with the general population.

METHODS: This multicenter, retrospective cohort study used TriNetX, a global federated research database. Using International Statistical Classification of Diseases, Tenth Revision, Clinical Modification codes, patients with a diagnosis of SLE or SjD in the general population, as well as those …

Social Determinants Of Occupational Injuries Among Us-Based Commercial Fishermen: A Systematic Review, Shannon Guillot-Wright, Leonard Kuan-Pei Wang, Bibiana Toro Figueira, Mary Overcash Jones, Ruhi Maredia, Nikhita Kichili

Faculty, Staff and Student Publications

BACKGROUND: Commercial fishing is a multibillion-dollar industry that supports job growth, small- to large- businesses, and port and city revenue. The commercial fishing industry continues to be one of the most dangerous in the US, with a fatality rate nearly 40 times higher than the national average. Dangers of the fishing industry are multi-faceted and include hazardous working conditions, strenuous labor, long work hours, and harsh weather. Moreover, a vast majority of fishermen suffer from economic insecurity, including safe and affordable housing and food insecurity.

METHODS: We followed the recommendations and standards set by the Campbell and Cochrane Equity Methods …

Spartan Daily, January 23, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 1

Long–Term Performance And Stability Of Implanted Neural Interfaces In Individuals With Lower Limb Loss, Eileen Petros, Michael Miller, Jeremy Dunning, Gilles Pinault, Dustin Tyler, Ronald Triolo, Hamid Charkhkar

Student Scholarship

Objective. High-density nerve cuffs have been successfully utilized to restore somatosensation in individuals with lower-limb loss by interfacing directly with the peripheral nervous system. Elicited sensations via these devices have improved various functional outcomes, including standing balance, walking symmetry, and navigating complex terrains. Deploying neural interfaces in the lower limbs of individuals with limb loss presents unique challenges, particularly due to repetitive muscle contractions and the natural range of motion in the knee and hip joints for transtibial and transfemoral amputees, respectively. This study characterizes the long-term performance of these peripheral nerve interfaces, which is crucial for informing design modifications …

Reduced Autoimmunity Associated With Deletion Of Host Cd73, Beanna Okeugo, Shabba A Armbrister, Rhea C Daniel, Zeina M Saleh, Jessica Wang, Salomea Giorgberidze, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

CD73 is ubiquitously expressed and regulates critical functions across multiple organ systems. The sequential actions of CD39 and CD73 accomplish the conversion of adenosine triphosphate to adenosine and shift the adenosine triphosphate-driven proinflammatory immune cell milieu toward an anti-inflammatory state. This immunological switch is a major mechanism by which regulatory T (Treg) cells control inflammation. Foxp3 engages in Treg development and function. Foxp3 mutations result in the scurfy (SF) mouse phenotype and a rapidly lethal lymphoproliferative syndrome. We generated double knockout (KO) mouse (CD73KOSF) by breeding heterozygous Foxp3sf/J females to CD73KO male mice to remove host CD73. We initially aimed …

Safeguarding Submarine Cables And Pipelines In Times Of Peace And War, Raul (Pete) Pedrozo

International Law Studies

Incidents involving damage to undersea infrastructure illustrate the vulnerability of submarine cables and pipelines. While damage can occur accidentally in peacetime, recent incidents suggest cables and pipelines are being systematically targeted and that the resulting damage is not accidental or the result of poor seamanship. Most undersea infrastructure can also be attacked as a military objective in wartime. Peacetime adversaries or opposing belligerents during an armed conflict can easily damage undersea infrastructure to further their political, strategic, or wartime objectives. These incidents also highlight the inadequacy of coastal State authority under international law to take measures against foreign-flagged vessels intentionally …

Mental Health In Preprofessional And Professional Circus Artists: A Narrative Review, Melanie I. Stuckey, Stephanie Greenspan, Joanna Nicholas, Veronique Richard, Janine H. Stubbe, Fleur E.C.A. Van Rens

Research outputs 2022 to 2026

Mental health has received little attention in preprofessional and professional circus despite the performance demands, cognitive skill, and emotional labor required. This review aimed to consolidate the literature, identify research gaps, and guide practice priorities for mental health in preprofessional and professional circus artists. A narrative review of the literature was conducted based on the International Olympic Committee’s 2019 consensus statement for mental health in elite athletes. Articles reported on mental health symptoms and disorders (n = 13) and interventions (n = 3) in preprofessional and professional circus contexts. Circus artists may experience more symptoms of depression, anxiety, fatigue, and …

Electrochemical Insights Into The Direct Dissolution Of Impure Sphalerites And Their Partial Oxidation In An Acidic Environment, Gholamreza Khodadadmahmoudi, Saeid Karimi, Hadi Abdollahi, Milad Karimi, Ali Rezaei, Lana Alagha

Mining Engineering Faculty Research & Creative Works

This study examined the electro dissolution mechanism of five impure sphalerite samples, which differ significantly in purity levels, along with their partially oxidized counterparts in a 0.5 M H₂SO₄. Partially oxidized samples were prepared through an incomplete leaching of sphalerite using H₂SO₄ with Fe₂(SO₄)₃.H₂O as an oxidizing agent. The original sphalerite samples and the partially oxidized samples were referred to as SP and POS samples, respectively. Analyses using XRD, SEM, Raman spectroscopy, and electrochemical techniques suggested presence of elemental sulfur and a metal-deficient layer on …

Proximal Remote Sensing: An Essential Tool For Bridging The Gap Between High-Resolution Ecosystem Monitoring And Global Ecology, Zoe Amie Pierrat, Troy S. Magney, Will P. Richardson, Benjamin R. K. Runkle, Jen L. Diehl, Xi Yang, William Woodgate, William K. Smith, Miriam R. Johnston, Yohanes R. S. Ginting, Gerbrand Koren, Loren P. Albert, Christopher L. Kibler, Bryn E. Morgan, Mallory Barnes, Adriana Uscanga, Charles Devine, Mostafa Javadian, Karem Meza, Tommaso Julitta, Giulia Tagliabue, Matthew P. Dannenburg, Michal Antala, Christopher Y. S. Wong, Andre L. D. Santos, Koen Hufkens, Julia K. Marrs, Atticus E. L. Stovall, Yujie Liu, Joshua B. Fisher, John A. Gamon, Kerry Cawse-Nicholson

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A new proliferation of optical instruments that can be attached to towers over or within ecosystems, or ‘proximal’ remote sensing, enables a comprehensive characterization of terrestrial ecosystem structure, function, and fluxes of energy, water, and carbon. Proximal remote sensing can bridge the gap between individual plants, site-level eddy-covariance fluxes, and airborne and spaceborne remote sensing by providing continuous data at a high-spatiotemporal resolution. Here, we review recent advances in proximal remote sensing for improving our mechanistic understanding of plant and ecosystem processes, model development, and validation of current and upcoming satellite missions. We provide current best practices for data availability …

The Journey Toward Sustainability: Positive Impact Of Environmental, Social, And Governance Index On Transportation., Doreen Mcgunagle, Laura Zizka, Ron Mau, Patti Clark

Publications

The transportation industry has been criticized for its hefty environmental footprint, questionable social practices, and lack of transparency regarding governance. Thus, more companies have begun including Environmental, Social, and Governance (ESG) issues in their strategies. Research has shown that effectively integrating ESG into business models can improve financial performance by tackling environmental, social, and governance challenges. This sustainable progress can be quantified by considering the extent to which the products or services produced by the firm’s harm or benefit social welfare. The current research paper examines ESG and financial performance over time in the Transportation Industry by comparing data from …

Montana Kaimin, January 23, 2025, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Analysis Of Open Government: A Review Of Food Security And Independence Policy In Bojonegoro, Vita Nugrah Septiana, Ana Kumalasari*, Junadi Junadi, Hussein Gibreel Musa

Jurnal Wacana Politik

This study examines how Open Government initiatives enhance the effectiveness of the Independent Farmer Card (KPM) Plus Program and their subsequent impacts on Food Security and Food Independence among rural communities. The research problem of this study is that some farmers lack an understanding of how to access support and follow application instructions for agricultural aid through the KPM Plus Program. The research analyzes the impact of transparency, participation, and collaboration within government frameworks on agricultural support. The findings highlight that Open Government initiatives significantly enhance the effectiveness of the KPM Plus Program, leading to better food security and independence …

Fresh Looks, Familiar Voices: Balancing Conformity And Differentiation In Young Adult Literature Market, Nami Kim, Jiyoon An

AMTP Proceedings 2025

This study examines optimal distinctiveness strategies in the Young Adult (YA) literature market, analyzing bestseller data across visual representation, author concentration, content diversification, and linguistic evolution. Results reveal increasing visual differentiation in book covers, growing reliance on established authors, gradual expansion of content diversity, and linguistic convergence in book descriptions. These findings demonstrate how publishers dynamically adjust various product aspects to achieve optimal distinctiveness, extending optimal distinctiveness theory to brand-level strategies in cultural industries.