Digital Commons Network^™

Ligand Distances As Key Predictors Of Pathogenicity And Function In Nmda Receptors, Ludovica Montanucci, Tobias Brünger, Nisha Bhattarai, Christian M Boßelmann, Sukhan Kim, James P Allen, Jing Zhang, Chiara Klöckner, Ilona Krey, Piero Fariselli, Patrick May, Johannes R Lemke, Scott J Myers, Hongjie Yuan, Stephen F Traynelis, Dennis Lal

Faculty, Staff and Student Publications

Genetic variants in the genes GRIN1, GRIN2A, GRIN2B, and GRIN2D, which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic and neurodevelopmental disorders, including early onset epilepsy, developmental and epileptic encephalopathy, intellectual disability, and autism spectrum disorders. Missense variants in these genes can result in gain or loss of the NMDAR function, requiring opposite therapeutic treatments. Computational methods that predict pathogenicity and molecular functional effects of missense variants are therefore crucial for therapeutic applications. We assembled 223 missense variants from patients, 631 control variants from the general population, and 160 missense variants characterized by …

The Roles Of Supervisor Care And Trust And Sense Of Belonging In Promoting Internship Satisfaction, Melinda K. Adams, Jody E. Jessup-Anger

College of Education Faculty Research and Publications

This study examines how relational aspects of the internship experience, namely students’ perceptions of a supervisor’s care and trust and students’ sense of belonging, factor into students’ satisfaction with their internship experience. We found that relational aspects impacted internship satisfaction. Although students’ perceptions of a supervisor’s care and trust were not a significant predictor of satisfaction, their sense of belonging was significant. Further analysis pointed to opportunities to use career related skills and gain confidence to pursue future job opportunities as significant in building students’ sense of belonging.

Research Review: "Veteran Affairs Disability Compensation: Likely The U.S.’S Largest Disability Program, But What Do We Know About Its Impacts On Service-Disabled Veterans?", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This research review highlights the complexities of estimating the causal impacts of the Veterans Affairs Disability Compensation (VADC) program. The authors suggest that reliable estimates of the causal impact of VADC on labor market outcomes requires estimates of the causal impact of other programs available to veterans with service-connected disabilities. Currently, there is limited evidence of the causal impact of these programs, pointing to several opportunities for practice, policy, and future research.

Act-Enhanced Peer Coaching For Online Act Self-Help: Feasibility And Acceptability With College Students, Korena S. Klimczak, Michael P. Twohig, Gretchen G. Peacock, Michael E. Levin

Psychology Student Research

Objective: This secondary analysis examined the feasibility and acceptability of a novel peer coaching model designed to improve adherence to an online self-help program based on Acceptance and Commitment Therapy (ACT), called ACT Guide. Participants: All participants (N = 152) and peer coaches were undergraduate students attending the same university. Methods: Participants were instructed to use ACT Guide for 10 weeks and were randomly assigned to receive weekly peer coaching through either phone calls or text messaging. Results: We found our peer coaching model to be feasible for delivery via phone and text, however acceptability …

“It Was Oddly Cathartic And Just Good - Freeing”: An Adaptation Of A Cognitive Restructuring Task For Non-Binary People Experiencing Sexual Objectification, Lee R. Pradell, Joshua G. Parmenter, Renee V. Galliher, Elizabeth Grace Wong, Kevin Chi, Hanna Huenemann, Lindsey Rowley, Sadie South

Psychology Student Research

The present study uses action research and critical trans theory frameworks to adapt a cognitive restructuring task to assist non-binary people in minimizing internalization from sexual objectification experiences (SOEs). Nine non-binary participants completed process charts documenting their experiences with SOEs. Participants also completed interviews about their experience with the process chart. Findings explored the nine categories of the process chart and the process of completing the process charts, highlighting the power participants reclaimed by interrogating objectifying sentiments and managing their environments in the wake of SOEs. We discuss utilizing our study’s process chart to better support marginalized people through SOEs.

Interior Fragments, Paramita Atmodiwirjo, Yandi Andri Yatmo

Interiority

The critical role of fragments in spatial discourse stems from the complex relationship between fragment and whole. The paradox of fragments offers a deeper understanding of how our architecture, interior, and urban systems are constructed by the presence of fragments and whole and, more importantly, by their interrelationship. Understanding fragments is more than just understanding them as independent spatial entities; it establishes knowledge of how fragments are constructed, connected, and negotiated. This issue of Interiority presents a collection of inquiries on fragments within various everyday interior contexts and representations, demonstrating the emergence of spatialities that celebrate interconnection possibilities beyond the …

Soul Surfers Forced Into A Fragmented Exteriority, Siti Balkish Roslan, Nor Atiah Ismail, Sumarni Ismail

Interiority

This study explores the profound impact of the COVID-19 pandemic on soul surfers, individuals for whom surfing transcends mere sport to embody a spiritual, psychological, and physical communion with the sea and ocean. The pandemic’s restrictions, which limited access to the sea, challenged the core of soul surfing practices, prompting surfers to seek alternative means to sustain their connection with the sea and ocean. Through qualitative research, employing phenomenological analysis, theories of affordance, symbolic interactionism, and interpretive interviews, the study examines the transition from a natural exterior to a built interior, adapting their living spaces to maintain their surfing identity, …

The Kitchen As A Social-Spatial Barometer: Deconstructing The Domestic Realm From A Gender Perspective, Serafina Amoroso, Atxu Amann Alcocer

Interiority

Emergent domesticities have generated new forms of urban life that have dissolved the historical duality between the home and the city. Last century's gender revolution in Western societies, together with contemporary technologies, has affected how people organise their daily lives. Everyday time has replaced typological space, blurring the lines between reproductive and productive activities and consequently affecting private and public spaces and how we live together. Pre- modern dwellings consisted of spatial spaces in which a few pieces of furniture were used to carry out everyday activities and were replaced in 18th-century bourgeois culture by spatial devices organised into 'room.' …

Fragments Within Fragments: The Collective Negotiation Of Exquisite Corpse Drawings, Defry Agatha Ardianta, Yandi Andri Yatmo, Paramita Atmodiwirjo

Interiority

This paper argues for the critical role of collective drawings as a form of representation that highlights the open process. The open process of collective drawing involves actions performed by multiple actors and actions that are not limited to producing drawings together but also require the expression of ideas. Collective drawing encourages negotiations among fragments of the drawing, which opens up various possibilities of representations within the interiority discourse. Exquisite corpse drawings made by Surrealist artists occupy an influential position as drawings produced via an open process regulated by the internal mechanism, manifesting as a continuous act of drawing. This …

Decrypting Interiority Of Albert Camus' The Stranger Through Absurdist Architectural Symbolism, Peter Akongfeh Agwu, Angela A. Ajimase, Edward Ugbada Adie, John Ogidi Acha

Interiority

Since its publication in 1942, Camus' The Stranger (L'Étranger in French) has captivated readers and scholars alike, sparking a wealth of critical analysis and interpretation. However, the novel's minimalist descriptions of interior spaces have often been overlooked in academic discourses, making it a perennial subject of further scholarly inquiry. This study seeks to decrypt the interiority of this text by examining the absurdist architectural symbolism and dissecting the spatial elements embedded in its narrative. The aim is to unveil new layers of meaning in the protagonist's internal psyche and existential condition. Through close reading and thematic analysis of relevant passages, …

Examining Organizational Changes In A Lead Organization With Local Chapters, Scottie Y. Mcclaney

Walden Dissertations and Doctoral Studies

This qualitative study examined the balance between local autonomy and organizational uniformity in a statewide nonprofit organization. Local chapters operated within the lead organization’s framework while retaining flexibility to establish their own bylaws, presenting challenges in communication, representation, and consistency. Guided by the research questions—How do the autonomous structures of the local chapters affect internal communication both within individual chapters and across local chapters? and To what extent do operational practices, methodologies, and goals vary across the local chapters, and are there identifiable lead practices that can be universally adopted to enhance the overall efficiency of chapters? —this study explored …

Improving Financial Employee Organizational Commitment During Post-Merger Integration, Natalie Yve Cote Canestro

Walden Dissertations and Doctoral Studies

Mergers and acquisitions (M&A) remain a top growth strategy for organizational leaders. However, the success of these initiatives is often undermined during post-merger integration (PMI) due to challenges in aligning organizational cultures, processes, and employee commitment. A lack of focus on enhancing employees’ organizational commitment (OC) during this critical phase can lead to disengagement, resistance to change, decreased productivity, and higher turnover rates. The purpose of the pragmatic inquiry was to explore how financial managers enhance their employees’ OC during PMI through the Leader-Member Exchange (LMX) framework. Data were collected through semistructured interviews of six financial managers. Data were then …

Mental Health And Wellness Among Plastic Surgeons During Oral Board Certification Examination Preparation., Hannah J. Bergman, Charles C. Jehle, Ibrahim Khansa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The field of plastic and reconstructive surgery has recently made a dramatic shift toward attention to mental health, with residency curricula expanding to include training on burnout prevention and the promotion of well-being. After graduation, however, new surgeons face a difficult year of preparation for the oral board certification examination. This group of young surgeons remains largely unstudied and undersupported throughout what may be the most challenging period of their educational journey.

METHODS: In spring of 2024, an electronic survey was sent to members of the American Society of Plastic Surgeons who had completed their oral board examination within …

Optimizing Ethanol-Water Cosolvent Systems For Green Supercritical Carbon Dioxide Extraction Of Muscadine Grape Pomace Polyphenols, Arda Tuhanioglu, Sumanjot Kaur, Gabriel Laquete De Barros, Safoura Ahmadzadeh, Renee Threlfall, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

This study evaluated the ethanol-water modified (50%, v/v) supercritical carbon dioxide (SC-CO2) for the extraction of polyphenols from muscadine grape (Vitis rotundifolia Michgx.) pomace and compared with conventional solvent extractions (ethanol-water and HCl-methanol). The process was optimized with a central composite response surface design consisting of three levels of three independent variables: pressure (20-40 MPa), temperature (40-60 degrees C), and cosolvent concentration (5-15%) to maximize three responses: total phenolic content (TPC), total flavonoid content (TFC), and resveratrol yields. The optimal conditions were determined as 20 MPa, 60 degrees C, and 15% cosolvent concentration with TPC, TFC, and resveratrol yields of …

The Middle Voice In Najdi Arabic: A Morphological Description, Abdulrahman N/A Althawab Dr., Sara Alotaishan Mrs.

Journal of Arabic Sciences and Humanities

Voice category is an essential grammatical aspect of verb constructions in linguistics. It is widely known that voice involves two main types: active and passive. However, there is a possibility of having a third grammatical voice known as the middle voice. Based on the relevant literature, the middle voice is a controversial topic that has aroused debate over its linguistic properties. This paper, therefore, aims to investigate some of the middle voice linguistic properties within a morphological context. More specifically, it attempts to identify the middle voice verb patterns and examine their existence using a linguistic test in one of …

Finding Their Voices: The Impact Of Explicit Instruction On Second Language Students’ Authorial Voice Construction In Argumentative Writing, Najlaa N/A Alharbi Dr.

Journal of Arabic Sciences and Humanities

Authorial voice, crucial for academic writing, reflects a writer's identity and engagement with readers. However, second-language (L2) writing instruction often prioritizes coherence over fostering this voice. This mixed-methods study explored the impact of explicit authorial voice instruction on 74 Saudi female undergraduate students' argumentative writing. Divided into experimental and control groups, the experimental group received voice instruction, while the control group continued with the standard curriculum. Pre and posttests along with focus group interviews were used for data collection. Results showed significant improvement in the presence and clarity of ideas, manner of presentation, and writer-reader engagement in the experimental group's …

Clinical Characteristics Of Patients With Copd And Comorbid Depression And Anxiety: Data From A National Multicenter Cohort Study, Jing Gennie Wang, Sonali Bose, Janet T Holbrook, Lin Nan, Michelle N Eakin, Abebaw M Yohannes, Robert A Wise, Nicola A Hanania

Faculty, Staff and Students Publications

Background: Most studies on mental health among individuals with chronic obstructive pulmonary disease (COPD) utilize screening questionnaires, which detect psychiatric symptoms, but cannot be used to diagnose depression/anxiety disorders. We utilized the Mini-International Neuropsychiatric Interview (MINI) to identify depression/anxiety disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnostic criteria and described associated disease burden in people with COPD.

Methods: This is a cross-sectional, secondary analysis of a multicenter study designed to evaluate anxiety questionnaires in COPD patients. Research coordinators administered both the MINI and screening questionnaires to determine participants who met diagnostic criteria for depression/anxiety …

Factors Associated With Link Workers Considering Leaving Their Role: A Cross-Sectional Survey, Stephanie Tierney, Lucy Moore, Debra Westlake, Kamal R. Mahtani, David Nunan, Kerryn Husk, Shoba Dawson, Jane Smith, Emma Fuller, Lilly Sabir, Pauline Roberts, Obioha C. Ukoumunne

Peninsula Medical School

Background: Social prescribing (SP) link workers (LWs) listen to patients’ concerns and difficulties, and connect them to relevant community assets (groups, organisations, or charities) that can help with their non-medical issues (for example, loneliness, debt, housing). LW retention is key to sustaining SP within primary care. Aim: To examine occupational self-efficacy, job discrepancy, and other factors as potential predictors of LWs’ intentions to leave or remain in their posts. Design & setting: Cross-sectional survey involving LWs from the United Kingdom. Method: An online questionnaire was distributed via SP-related organisations. Questions were on the following: (a) intention to leave the role; …

Dog Skull Shape Challenges Assumptions Of Performance Specialization From Selective Breeding, Nicholas Hebdon, Alexa Ortega, Alexander Orlove, Nichole Wheeler, Mia Pham, Vivian Nguyen, Justin Gladman, Lindsay D. Waldrop

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Through selective breeding, humans have driven exceptional morphological diversity in domestic dogs, creating more than 200 recognized breeds developed for specialized functional tasks such as herding, protection, and hunting. Here, we use three-dimensional reconstructions of dog skulls to ask whether these function-oriented kennel-club groups reflect differences in morphology that correspond to those functions. We analyzed 117 canid skulls, representing 40 domestic dog breeds and 18 wild subspecies, using geometric morphometric techniques and k-means clustering. Results show near-full overlap in kennel-club groups and with natural species, except for companion dogs having extreme snout shape. When categorized by task-specific historic function …

Evaluation Of Age-Related Spermatozoa Morphological Section Lengths In Gloster Canary Spermatozoa Using Computer Aided Sperm Analysis (Casa) System, Arda Onur Özkök, Burcu Esi̇n, Cumali̇ Kaya

The Thai Journal of Veterinary Medicine

The canary is a small passerine bird of the finch family. Canary spermatozoa are also morphologically similar to many other songbird species. In this study, the morphological characteristics of Gloster canary spermatozoa of different age ranges were examined, and the length values of the parts forming the spermatozoa were compared. The study used ten active Gloster canaries between the ages of 3 (Trial-1) and four years (Trial-2). Semen samples from 3-year-old canaries in the study were evaluated, and morphological segment lengths were recorded. In the study, to avoid individual differences and make homogeneous measurements, semen samples were retaken from the …

Local Tissue Damage Treatment Of Snake Venom, Suchitra Khunsap

The Thai Journal of Veterinary Medicine

Local tissue damage caused by snake envenomation was a medical problem that caused morbidity and mortality for more than a decade, with no defined treatment guidelines. Nowadays, antivenom is the primary treatment for snakebite, which substantially reduces systemic venom but not significantly reducing local symptoms. We compiled a list of local damage therapies, including antivenom medication, surgery and skin grafting, small molecule medicines, and alternative therapies. Although each was not approved as a standard treatment, it may be a treatment option for tissue damage caused by snake venom. However, antivenoms and most resistant compounds may not be the best strategy …

The Survey Of The Prevalence Of Equine Gastric Ulcer Syndrome (Egus) In Non-Racing Thoroughbred Horses In Thailand, Teerapol Tum Chinkangsadarn, Sangtawan Tubkleaw, Ananya Rungjarusub, Jitsupa Trangkatarn, Kawinthida Thaworn, Parichart Tesena

The Thai Journal of Veterinary Medicine

This study aimed to determine the prevalence, types, and risk factors of Equine Gastric Ulcer Syndrome (EGUS) in non-racing Thoroughbred horses in Thailand. A total of 56 Thoroughbreds, aged 5 to 22 years (mean age: 12.43 ± 4.65 years), were included. Before sedation, a comprehensive history and physical examination were conducted. Gastroscopy was performed to identify gastric ulcers, using the Equine Gastric Ulcer Council 0–4 scoring system for non-glandular ulcers, while glandular ulcers were assessed as present or absent. Data on breed, age, sex, activity status, behavior, appetite, and medical rehistory were collected. The overall prevalence of gastric ulcers was …

Instruction In Synthesis Writing Can Be Augmented By Giving Students A Generative Ai Prompt, Drew Loewe

Teaching Repository of AI-Infused Learning

This entry describes an AI-augmented strategy to assist students in synthesis writing, specifically in a general education writing course. The approach uses an instructor-created generative AI prompt to give additional in-process feedback on drafts, helping students identify and address common synthesis challenges such as patchwriting and sequential reporting. Preliminary results suggest that students using the AI prompt demonstrated increased confidence and improved synthesis skills, as indicated by both their self-reports and better assignment performance compared to previous semesters.

Ai-Integrated Cross-Disciplinary Liberal Arts Colloquium, Diana S. Perdue, Niloofar Gholamrezaei, Jennifer Krusinger, Shannon Hogan

Teaching Repository of AI-Infused Learning

What began organically as an AI-focused collaboration between faculty in different disciplines along with researchers in the college’s Center for Instructional Innovation, has evolved into college-wide pedagogical workshops and the development of a studio model that affects courses, programs, and paradigms for faculty scholarship.

Lessons from these collaborations inform understandings of how key features of liberal arts education can be supported through intentional AI-integration within a Cross-Disciplinary Liberal Arts Colloquium. More specifically, this colloquium offers recommendations on adapting a collaborative, interdisciplinary, and reflective studio model to in-person, online, and hybrid educational environments facilitated through a Technological Pedagogical Content Knowledge (TPACK) …

Oh, Hi!, John C. Lyden

Journal of Religion & Film

This is a film review of Oh, Hi! (2025) directed by Sophie Brooks.

Cultural Capital Skill Development In Undergraduate Kinesiology Curriculum, Jenica Alvarez, Sabrina R. Fordham, Elizabeth M. Harrison, Blake Podsen, Jason C. Casey, Rich Pruett

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 2, 2025. Specialization within Kinesiology and related fields over the past 20 years has led to the prioritization of technical skill development. This specialization leaves limited availability of resources for the development of Cultural Capital (CC) skills in undergraduate kinesiology and kinesiology-related curricula. The purpose of this study was to examine how seven Experiential Learning Activities (ELAs) influence CC skill development in an undergraduate kinesiology practicum course. An interpretive qualitative action research design was applied to investigate five senior undergraduate kinesiology students’ experiences. The study concluded: (a) six of …

Uncovering Acoustic Biomarkers To Classify Parkinson Disease Through Machine Learning, Felix Yeboah

Data Science and Data Mining

The early detection of diseases profoundly influences treatment efficacy, and accurate classification methodologies are essential for effective disease identification. In this project, we examined fve different classifers—Logistic Regression, Gaussian Naive Bayes, K Nearest Neighbor (KNN), Extreme Gradient Boosting (XGBoost), and Support Vector Machines—and evaluated their performance in detecting Parkinson’s disease (PD) based on voice features. The study aims to identify the best classifier for detecting PD. XGBoost performed the best, with an accuracy of 91% on the full dataset. After variable selection, KNN had the best performance with an accuracy of 91%. These findings suggest that Machine learning algorithms(classifiers) can …

Two Women, John C. Lyden

Journal of Religion & Film

This is a film review of Two Women (2025), directed by Chloé Robichaud.

Exploration Of Running In Minimal And Conventional Footwear On Tibial Stress Fracture Probability In Habitual And Non-Habitual Minimal Users, Jonathan K. Sinclair, Paul J. Taylor

Baltic Journal of Health and Physical Activity

This research sought to investigate the impact of minimal and conventional footwear on the likelihood of tibial stress fractures among individuals who habitually and do not habitually use minimal footwear. Ten males who habitually ran in minimal footwear and ten males who habitually ran in conventional footwear, took part in this investigation. Kinematic information during overground running were gathered using an eight-camera motion-capture system, and ground reaction forces were recorded using a force plate. Tibial strains were assessed through finite element modelling, while the likelihood of stress fractures was determined through probabilistic modelling across a 100-day running period. Medial tibial …

Emergency Room Utilization Rates Among Unhoused Patients Receiving Care At A Student-Led Free Clinic, Lindsey Torres, Tina Gustin

Graduate Student Government Association Research Conference

Purpose statement: The purpose of this activity is to allow the learner to recognize the impact of a student-led clinic aimed at caring for those living in homelessness by providing accessible primary care and minimizing barriers to reduce avoidable emergency room utilization.

Objectives:

1. At the end of the presentation, learners will be able to discuss and demonstrate knowledge of outcomes related to emergency room visits when student-led clinics are implemented in their region.
2. To identify the most common reasons persons living in homelessness present to the emergency room to expand services in future practice.

Background: Studies have determined that unhoused …