Digital Commons Network^™

Cost-Effectiveness Analysis Of Favipiravir And Remdesivir As Covid-19 Treatment In South Tangerang, Banten Province - Indonesia, Wahyu G. Putro, Andriani R. Fahriyati, Gilberto A. Julian, Tania R. Amalia, Zaki M. Riski

Pharmacology and Clinical Pharmacy Research

COVID-19 is a contagious ailment primarily attributed to the severe acute respiratory syndrome coronavirus. Indonesia persists in confronting the COVID-19 pandemic, and South Tangerang City has emerged as one of the municipalities in Indonesia that has been significantly affected. There are two categories of medications employed for COVID-19 treatment according to government policies, namely favipiravir and remdesivir. This study aims to as- sess the cost-effectiveness of favipiravir and remdesivir medications at the South Tangerang General Hospital, Indonesia. The present study employs a retrospective research design characterized by a quantitative approach, utilizing cross-sectional methodologies. The analy- sis mostly consists of descriptive …

The Unprecedented Stressors Of Early Childhood Educators During The Covid-19 Pandemic And Post-Pandemic Restoration: A Case Study, Ida Mae Lewis

Doctoral Dissertations and Projects

The purpose of this case study was to describe the unprecedented stressors of early childhood educators (ECE) during the COVID-19 pandemic and the post-pandemic restoration at two early childhood education centers (ECEC) in a midwestern state. The central research question was: How did the COVID-19 pandemic’s unprecedented stressors impact ECE in the post-pandemic era? Data collection included structured interviews with open-ended questions, focus groups, and documents. The three data sources were triangulated for themes, perspectives, and interpretations, and coding was used to help gain a deep understanding of the stressors experienced by early childhood educators. The conceptual framework guiding this …

Coded Social Control: China’S Normalization Of Biometric Surveillance In The Post Covid-19 Era, Michelle Miao

Washington Journal of Law, Technology & Arts

This article investigates the longevity of health QR codes, a digital instrument of pandemic surveillance, in post-COVID China. From 2020 to 2022, China widely used this tri-color tool to combat the COVID-19 pandemic. A commonly held assumption is that health QR codes have become obsolete in post-pandemic China. This study challenges such an assumption. It reveals their persistence and integration - through mobile apps and online platforms - beyond the COVID-19 public health emergency. A prolonged, expanded and normalized use of tools which were originally intended for contact tracing and pandemic surveillance raises critical legal and ethical concerns. Moreover, their …

Assessing Covid-Related Concerns And Their Impact On Antenatal And Delivery Care Among Pregnant Women Living With Hiv In Kenya: A Brief Report., Catherine Wexler, May Maloba, Sharon Mokua, Shadrack Babu, Nicodemus Maosa, Vincent Staggs, Kathy Goggin, Harshdeep Acharya, Emily A. Hurley, Sarah Finocchario-Kessler

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Some studies indicate that pregnant Kenyan women were concerned about Coronavirus disease 2019 (COVID-19) exposure during maternity care. We assessed concern regarding COVID-19 exposure and any impact on antenatal care (ANC) enrollment and/or hospital delivery among pregnant women living with human immunodeficiency virus (HIV) in Kenya.

METHODS: Data were collected from 1,478 pregnant women living with HIV enrolled in prevention of mother to child transmission of HIV (PMTCT) care at 12 Kenyan hospitals from October 2020 to July 2022. Surveys were conducted when women first presented for PMTCT services at the study hospital and asked demographic questions as well …

Soft Computing-Based Generalized Least Deviation Methodalgorithm For Modeling And Forecasting Covid-19 Usingquasilinear Recurrence Equations, Mostafa Abotaleb

Iraqi Journal for Computer Science and Mathematics

This study introduces an advanced algorithm based on the Generalized Least Deviation Method(GLDM) tailored for the univariate time series analysis of COVID-19 data. At the core of this approach is theoptimization of a loss function, strategically designed to enhance the accuracy of the model’s predictions. Thealgorithm leverages second-order terms, crucial for capturing the complexities inherent in time series data. Ourfindings reveal that by optimizing the loss function and effectively utilizing second-order model dynamics, there is amarked improvement in the predictive performance. This advancement leads to a robust and practical forecasting tool,significantly enhancing the accuracy and reliability of univariate time series …

Naturally Derived Phenethyl Isothiocyanate Modulates Induction Of Oxidative Stress Via Its N-Acetylated Cysteine Conjugated Form In Malignant Melanoma, Sotiris Kyriakou, Nikoletta Demosthenous, Tom Amery, Kyle J. Stewart, Paul G. Winyard, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis

School of Veterinary and Biomedical Sciences: Faculty Publications

Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The aim of the current study was to assess the role of a naturally derived PEITC-enriched extract in the induction of oxidative stress and to evaluate its anti-melanoma potency through the regulation of its metabolism with the concurrent production of the N-acetyl cysteine conjugated by-product. For this purpose, an in vitro melanoma model was utilized consisting of human primary (A375) cells as well as metastatic (COLO-679) malignant melanoma cells together with non-tumorigenic immortalized keratinocytes (HaCaT). …

Prescribing Pattern Of Vitamins In Dermatologic Disorders At Tertiary Care Teaching Hospital In Western India, Zankrut J. Patel, Akanksha Prajapati, Cidhi Thaker, Sumit Patel

Pharmacology and Clinical Pharmacy Research

Skin ailments are a major burden in society. It is thought that Vitamins may help in improving skin health and appearance, but their deficiency may cause disease. The data regarding vitamin usage patterns in dermatologic practice in India is lacking. Therefore, the present study has been planned to analyze the prescribing pattern of vitamins. A cross-sectional, observational study was carried out at the outpatient department of dermatology at GCSMCH and RC, Ahmedabad, for 12 months from October 2019 to September 2020. Prescriptions of 500 patients were analyzed for common skin conditions and prescribing patterns. All the data were compiled into …

Wilms’ Tumor 1 (Wt1) Antigen Is Overexpressed In Kaposi Sarcoma And Is Regulated By Kshv Vflip, Ayana E. Morales, Ruby Gumenick, Caitlin M. Genovese, Yun Yeong Jang, Ariene Ouedraogo, Maite Ibáñez De Garayo, Tania Pannellini, Sanjay Patel, Matthew E. Bott, Julio Alvarez, Sung Soo Mun, Jennifer Totonchy, Archana Gautam, Jesus Delgado De La Mora, Stephanie Chang, Dagmar Wirth, Marcelo Horenstein, Tao Dao, David A. Scheinberg, Paul G. Rubinstein, Aggrey Semeere, Jeffrey Martin, Catherine C. Godfrey, Carlee B. Moser, Roy M. Matining, Thomas B. Campbell, Margaret Z. Borok, Susan E. Krown, Ethel Cesarman

Pharmacy Faculty Articles and Research

In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by KS herpesvirus (KSHV/HHV-8), remains one of the most common malignancies worldwide. Individuals living with HIV, receiving otherwise effective antiretroviral therapy, may present with extensive disease requiring chemotherapy. Hence, new therapeutic approaches are needed. The Wilms’ tumor 1 (WT1) protein is overexpressed and associated with poor prognosis in several hematologic and solid malignancies and has shown promise as an immunotherapeutic target. We found that WT1 was overexpressed in >90% of a total 333 KS biopsies, as determined by immunohistochemistry and image analysis. Our largest cohort from ACTG, consisting …

D-Mannose Reduces Cellular Senescence And Nlrp3/Gasdermind/Il-1Β-Driven Pyroptotic Uroepithelial Cell Shedding In The Murine Bladder, Chetanchandra S Joshi, Arnold M Salazar, Caihong Wang, Marianne M Ligon, Rayvanth R Chappidi, Bisiayo E Fashemi, Paul A Felder, Amy Mora, Sandra L Grimm, Cristian Coarfa, Indira U Mysorekar

Faculty, Staff and Students Publications

Aging is a risk factor for disease via increased susceptibility to infection, decreased ability to maintain homeostasis, inefficiency in combating stress, and decreased regenerative capacity. Multiple diseases, including urinary tract infection (UTI), are more prevalent with age; however, the mechanisms underlying the impact of aging on the urinary tract mucosa and the correlation between aging and disease remain poorly understood. Here, we show that, relative to young (8-12 weeks) mice, the urothelium of aged (18-24 months) female mice accumulates large lysosomes with reduced acid phosphatase activity and decreased overall autophagic flux in the aged urothelium, indicative of compromised cellular homeostasis. …

Regional Geographies And Public Health Lessons Of The Covid-19 Pandemic In The Arctic, Sweta Tiwari, Andrey N. Petrov, Nikolay Golosov, Michele Devlin, Mark Welford, John Degroote, Tatiana Degai, Stanislav Ksenofontov

Faculty Publications

Objectives: This study examines the COVID-19 pandemic’s spatiotemporal dynamics in 52 sub-regions in eight Arctic states. This study further investigates the potential impact of early vaccination coverage on subsequent COVID-19 outcomes within these regions, potentially revealing public health insights of global significance. Methods: We assessed the outcomes of the COVID-19 pandemic in Arctic sub-regions using three key epidemiological variables: confirmed cases, confirmed deaths, and case fatality ratio (CFR), along with vaccination rates to evaluate the effectiveness of the early vaccination campaign on the later dynamics of COVID-19 outcomes in these regions. Results: From February 2020 to February 2023, the Arctic …

Elevated Lead Levels In Urban House Sparrows: A Threat To Sharp-Shinned Hawks And Merlins?, Richard B. Chandler, Allan M. Strong, Carlin C. Kaufman

Journal of Raptor Research

No abstract provided.

Mortality, Morbidity, And Lead Poisoning Of Eagles In Western Canada, 1986-98, Mark Wayland, Laurie K. Wilson, John E. Elliott, Michael J. Miller, Trent Bollinger, Malcolm Mcadie, Ken Langelier, Jonathan Keating, Jennifer M. Froese

Journal of Raptor Research

No abstract provided.

A Retrospective Study Of Postmortem Findings In Red-Tailed Hawks, J. Christian Franson, Nancy J. Thomas, Milton R. Smith, Alison H. Robbins, Scott Newman, Paul C. Mccartin

Journal of Raptor Research

No abstract provided.

Diagnostic Findings In 132 Great Horned Owls, J. Christian Franson, Susan E. Little

Journal of Raptor Research

No abstract provided.

Parasitic Helminths Of Six Species Of Hawks And Falcons In Florida, John M. Kinsella, Garry W. Foster, Donald J. Forrester

Journal of Raptor Research

No abstract provided.

Blood Parasites Of Raptors In Florida, Donald J. Forrester, Sam R. Telford Jr., Garry W. Foster, Gordon F. Bennett

Journal of Raptor Research

No abstract provided.

Facts And Artefacts In Nest-Box Studies: Implications For Studies Of Birds Of Prey, Anders Pape Moller

Journal of Raptor Research

No abstract provided.

Diet Of The Red-Backed Buzzard (Buteo Polyosoma Exsul) And The Short-Eared Owl (Asio Flammeus Suinda) In The Juan Fern, Marcelo A. Fuentes, Javier A. Simonetti, M. Soledad Sepulveda, Patricia A. Acevedo

Journal of Raptor Research

No abstract provided.

Precocious Nest Defense Behavior By A Sharp-Shinned Hawk, Robert N. Rosenfield, Andrew Kanvik

Journal of Raptor Research

No abstract provided.

Book Reviews, Journal Of Raptor Research

Journal of Raptor Research

No abstract provided.

Serological Investigation Of Captive And Free Living Raptors, Hans Riemann, Darrell Behymer, Murray Fowler, Dave Ley, Terry Schultz, Roger Ruppanner, Jeff King

Journal of Raptor Research

No abstract provided.

Translation: A Brief Report On Virus Hepatitis In The Eagle Owl, Karl Borg, G. Rockborn

Journal of Raptor Research

No abstract provided.

Secreted Igm Modulates Il-10 Expression In B Cells, Shannon Mcgettigan, Lazaro Aira, Gaurav Kumar, Romain Ballet, Eugene Butcher, Nicole Baumgarth, Gudrun Debes

Department of Microbiology and Immunology Faculty Papers

IL-10⁺ B cells are critical for immune homeostasis and restraining immune responses in infection, cancer, and inflammation; however, the signals that govern IL-10⁺ B cell differentiation are ill-defined. Here we find that IL-10⁺ B cells expand in mice lacking secreted IgM ((s)IgM^–/–) up to 10-fold relative to wildtype (WT) among all major B cell and regulatory B cell subsets. The IL-10⁺ B cell increase is polyclonal and presents within 24 hours of birth. In WT mice, sIgM is produced prenatally and limits the expansion of IL-10⁺ B cells. Lack of the high affinity …

Critical-Size Defects Reconstruction With Four Different Bone Grafts Associated With E-Ptfe Membrane: A Histomorphometric Experimental In Vivo Study, Gustavo Fernandes, Filipe Castro, Rafael Martins Pereira, Wendel Teixeira, Sergio Gehrke, Julio Cesar Joly, Juan Blanco Carrion, Juliana Campos Hasse Fernandes

MOSDOH Faculty Publications

Objectives: The goal of this study was to assess the newly formed bone and the remnant biomaterial by comparing four different bone grafts used to treat critical-size defects, associated or not with the non-resorbable membrane.

Materials and methods: Two calvaria critical-size bone defects were created in 50 male Wistar rats. They were divided into blood (G1), autogenous (G2), bioglass (G3), hydroxyapatite (G4), and xenograft (G5) groups, associated or not with e-PTFE. The experimental periods were 15 and 45 days. Sections were prepared for histomorphometric assessment. All data were analyzed by the mixed-effects model with multiple comparisons (significance level, p < .05).

Results: …

Evaluation Of Knowledge, Attitude And Practice Of Dental Interns About Using Antibiotics In Pediatric Dentistry, Ahmad Safwat Aied, Norhan Abd El-Wahab El-Dokky, Rania Abdallah Nasr

Future Dental Journal

Introduction: Antimicrobial resistance is one of the ten threats identified by the World Health Organization (WHO) in 2019, since it affects modern healthcare and the effective prevention and treatment of an ever-increasing range of infections. Recent estimates of the burden of antimicrobial resistance are very significant, with more than half a million cases of infection with selected antibiotic-resistant bacteria or new emerging resistant pathogens occurring in Europe; of note, data regarding antimicrobial resistance in low-income countries are largely unknown, increasing the overall risk of mortality, in particular in surgical procedures

Aim: The aim of the study was to evaluate the …

Aligning Tobacco Free Living Agendas In A Community Health Improvement Plan: A Case Study On Democratic Participation And Economic Interests In U.S. Health Policy Development, David B. Tataw

Journal of Public Management & Social Policy

This paper addresses the gap in studies which use democratic policy making frameworks to analyze health policy development in Community Health Improvement Plans (CHIPs). The study describes and analyzes three streams of the tobacco free living policy cycle in a Community Health Improvement Plan implemented in a Mid-Western Region of the United States from 2016 to 2020. The roles of public health interest, economic interests, and democratic participatory rights in Tobacco free health policy making are assessed. The policy making process is assessed within an integrated framework of analysis that weaves pluralist, power elite, critical democratic theories, and participatory governance …

Fitting A Covid-19 Model Incorporating Senses Of Safety And Caution To Local Data From Spartanburg County, South Carolina, D. Chloe Griffin, Amanda Mangum

CODEE Journal

Common mechanistic models include Susceptible-Infected-Removed (SIR) and Susceptible-Exposed-Infected-Removed (SEIR) models. These models in their basic forms have generally failed to capture the nature of the COVID-19 pandemic's multiple waves and do not take into account public policies such as social distancing, mask mandates, and the ``Stay-at-Home'' orders implemented in early 2020. While the Susceptible-Vaccinated-Infected-Recovered-Deceased (SVIRD) model only adds two more compartments to the SIR model, the inclusion of time-dependent parameters allows for the model to better capture the first two waves of the COVID-19 pandemic when surveillance testing was common practice for a large portion of the population. We find …

A Baker’S Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2022, Reagan K. Barfield, Matthew L. Brown, Benjamin Albrecht, Katie E. Barber, Jeannette Bouchard, Amy L. Carr, Elias B. Chahine, David Cluck, Elizabeth W. Covington, Connor R. Deri, Spencer H. Durham, Carmen Faulkner-Fennell, Lauren K. Freeman, Timothy P. Gauthier, Geneen M. Gibson, Sarah B. Green, Athena L.V. Hobbs, Bruce M. Jones, P. Brandon Bookstaver Pharm.D., Et. Al.

Faculty Publications

Keeping abreast of the antimicrobial stewardship–related articles published each year is challenging. The Southeastern Research Group Endeavor identified antimicrobial stewardship–related, peer-reviewed literature that detailed an actionable intervention during 2022. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight actionable interventions used by antimicrobial stewardship programs to capture potentially effective strategies for local implementation.

Epidemiology And Antimicrobial Resistance Trends Of Acinetobacter Species In The United Arab Emirates: A Retrospective Analysis Of 12 Years Of National Amr Surveillance Data, Jens Thomsen, Najiba M. Abdulrazzaq, Hussain Alrand, The Uae Amr Surveillance Consortium, Dean B. Everett, Abiola Senok, Godfred A. Menezes, Carole Ayoub Moubareck

All Works

Introduction: Acinetobacter spp., in particular A. baumannii, are opportunistic pathogens linked to nosocomial pneumonia (particularly ventilator-associated pneumonia), central-line catheter-associated blood stream infections, meningitis, urinary tract infections, surgical-site infections, and other types of wound infections. A. baumannii is able to acquire or upregulate various resistance determinants, making it frequently multidrug-resistant, and contributing to increased mortality and morbidity. Data on the epidemiology, levels, and trends of antimicrobial resistance of Acinetobacter spp. in clinical settings is scarce in the Gulf Cooperation Council (GCC) and Middle East and North Africa (MENA) regions. Methods: A retrospective 12-year analysis of 17,564 non-duplicate diagnostic Acinetobacter spp. isolates …

Identifying Opportunities For Prevention Of Adverse Outcomes Following Female Genital Fistula Repair: Protocol For A Mixed-Methods Study In Uganda, Alison El Ayadi, Susan Obore, Fred Kirya, Suellen Miller, Abner Korn, Hadija Nalubwama, John Neuhaus, Monica Getahun, Patrick Eyul, Robert Twine, Erin Andrew, Justus Barageine

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Female genital fistula is a traumatic debilitating injury, frequently caused by prolonged obstructed labor, affecting between 500,000-2 million women in lower-resource settings. Vesicovaginal fistula causes urinary incontinence, and other morbidity may occur during fistula development. Women with fistula are stigmatized, limit social and economic engagement, and experience psychiatric morbidity. Improved surgical access has reduced fistula consequences yet post-repair risks impacting quality of life and well-being include fistula repair breakdown or recurrence and ongoing or changing urine leakage or incontinence. Limited evidence on risk factors contributing to adverse outcomes hinders interventions to mitigate adverse events. This study aims to quantify …