Digital Commons Network^™

Centralizing Pharmaceutical Innovation, Sapna Kumar

Maryland Law Review

No abstract provided.

Existence Of A Nonzero Worst-Case Ach For Short-Term Exposure In Ventilated Indoor Spaces, K. A. Krishnaprasad, ‪Nadim Zgheib, K. Choudhary, M. Y. Ha, C. Y. Choi, K. S. Bang, S. Jang, S. Balachandar

Mechanical Engineering Faculty Publications

A well-ventilated room is essential to reduce the risk of airborne transmission. As such, the scientific community sets minimum limits on ventilation with the idea that increased ventilation reduces pathogen concentration and thus reduces the risk of transmission. In contrast, the upper limit on ventilation is usually determined by human comfort and the need to reduce energy consumption. While average pathogen concentration decreases with increased ventilation, local concentration depends on multiple factors and may not follow the same trend, especially within short exposure times over large separation distances. Here, we show through experiments and high-fidelity simulations the existence of a …

Fibrinolytic-Deficiencies Predispose Hosts To Septicemia From A Catheter-Associated Uti, Jonathan J Molina, Wei Xu, Karla Bergeron, Aleksandra Klim, Michael G Caparon, Scott J Hultgren, Alana Desai, Et Al.

2020-Current year OA Pubs

Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens. Using our established mouse model of CAUTI, here we identified that host populations exhibiting either genetic or acquired fibrinolytic-deficiencies, inducing fibrin deposition …

The Imitation Game: Drug Reaction Presenting As Autoimmunity Presenting As Syphilis, Victoria W. Murray, Liam Courtney, Judith Lightfoot

Graduate Student and Postdoctoral Fellow Symposium

Introduction: Syphilis screening, a common medical test in the US, is recommended annually in sexually active women younger than 25, annually for women older than 25, and annually for men(1). Standard tests include rapid reagin tests and Venereal Disease Research Laboratory tests, which react to membrane antigens of Treponema pallidum(2). Case reports of patients with autoimmune conditions have been described (3) but rarely considered in clinical practice. Additionally, patients may be underdiagnosed with autoimmune conditions with clinically relevant antibodies (4). Here, we describe one such case where a patient received delay in care prior to referral to our service. Case …

Ebola Distribution Prediction In Africa

Defensive Publications Series

Ebola Virus Disease (EVD) is a deadly illness with a fatality rate around 50%, which can spike to 90% during outbreaks. First identified in 1976 near the Ebola River in the Democratic Republic of Congo, EVD has caused sporadic but devastating outbreaks. The recent epidemic in West Africa is the most significant yet, affecting Guinea, Sierra Leone, and Liberia the most due to their weak healthcare systems. This situation has highlighted the need for better global health security and international cooperation to manage such diseases. Our paper focuses on these three countries to analyze the outbreak and response strategies, aiming …

Methionyl-Trna Synthetase Synthetic And Proofreading Activities Are Determinants Of Antibiotic Persistence, Whitney N. Wood, Miguel Angel Rubio, Lorenzo Eugenio Leiva, Gregory J. Phillips, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Bacterial antibiotic persistence is a phenomenon where bacteria are exposed to an antibiotic and the majority of the population dies while a small subset enters a low metabolic, persistent, state and are able to survive. Once the antibiotic is removed the persistent population can resuscitate and continue growing. Several different molecular mechanisms and pathways have been implicated in this phenomenon. A common mechanism that may underly bacterial antibiotic persistence is perturbations in protein synthesis. To investigate this mechanism, we characterized four distinct metG mutants for their ability to increase antibiotic persistence. Two metG mutants encode changes near the catalytic site …

Hesitation Towards The Covid-19 Vaccine In The United States: A Digital Ethnographic Study [Vacilación Ante La Vacuna Contra El Covid-19 En Estados Unidos De América: Un Estudio Etnográfico Digital], Rosalynn A. Vega

Anthropology Faculty Publications

Following the authorization of the use of COVID-19 vaccines in babies age 6 months through children 4 years old in the United States, some individuals (parents, pediatricians, and communicators) framed COVID-19 vac-cination as an issue of access, while many others expressed hesitancy, and some resisted recommendations from the US Centers for Disease Control and Prevention. In this context, this study aimed to explore: 1) divergent reactions to the authorization of COVID-19 vaccine use in children aged 6 months to 4 years; and 2) opposing logics underlying attitudes towards pro-vaccination, anti-vaccination, and vaccine hesitancy regarding COVID-19 vaccines. To achieve this, a …

Exploring The Associations Between Drug Resistant Mutations, Low-Level Viremia, And Virological Failure In Persons With Hiv In Florida, Adriana Campos

USF Tampa Graduate Theses and Dissertations

Virologic suppression is an essential part to a successful regimen for Persons with HIV (PWH) and the 95-95-95 initiative. Yet, PWH experiencing episodes of low-level viremia (LLV) may be more prone to experience virological failure (VF). Currently, studies debate the clinical relevance of LLV and its effect on virological outcomes, but none have explored its interconnectedness with drug resistant mutations (DRM) and antiretroviral treatment (ART) adherence – all integral elements in predicting virological outcomes.

The goal of the proposed study was to contribute to the knowledge gap regarding the interconnectivity of drug resistant mutations, low-level viremia, adherence, and virological failure …

Community-Centered Early Warning For Outbreaks In Humanitarian Emergencies: Evaluating Community-Based Surveillance For Priority Communicable Diseases Among Internally Displaced Populations In Iraq, Caitlin M. Wolfe

USF Tampa Graduate Theses and Dissertations

Background: Community based surveillance (CBS) is the organized and rapid collection of information from health events identified in the community and includes the systematic detection and reporting of events of public health significance. While used globally to enhance the detection of priority diseases, CBS has not been routinely deployed in Iraq, where a once-robust health system has been devastated by decades of war, international sanctions, and large-scale population displacement. During infectious disease outbreaks, it is imperative to quickly detect and isolate suspect cases, investigate confirmed cases, and trace and monitor the contacts of confirmed cases. The COVID-19 pandemic underscored the …

Aggressive Behaviors Related To Delirium In Hospitalized Older Adults: A Systematic Review, Julia D. Trahan

LSU Master's Theses

This is a systematic review of the aggressive behaviors related to delirium in hospitalized older adults. The objective of this study was to review relevant literature regarding the moderation of delirious related aggressive behaviors within a hospital setting and examining the extent of interventions being conducted with aggression being a main factor. The eligibility factors for studies to be included were as follows: diagnosis of delirium, aggressive behaviors or agitation present, study occurring within a hospital setting, the goal of preventing aggressive behaviors, and participants must be over the age of 65. Academic Search Complete, PsychINFO, MEDLINE, SocINDEX, CINHAL Complete …

Efficacy And Feasibility Of Short-Stretch Compression Therapy For Filarial Lymphedema In Sri Lanka, Jaimee M Hall, Nirmitha Lalindi De Silva, Janaka Ruben, Sandani S Thilakarathne, Thishan Channa Yahathugoda, Philip J Budge

2020-Current year OA Pubs

The WHO-recommended essential package of care (EPC) for filarial limb lymphedema consists of daily limb washing, entry lesion management, limb protection, exercises, and elevation. Decongestive therapy (DT) with compression bandaging by trained lymphedema therapists adds additional benefit but is unavailable for most in low- and middle-income countries (LMICs). To determine whether DT using self-adjustable, short-stretch compression garments (SSCG), prefitted using portable, three-dimensional infrared imaging (3DII), would be effective and feasible in LMIC settings, we conducted a pilot 6-week, interventional, single-group, open-label pilot study in Galle, Sri Lanka. Ten participants with Dreyer stage 3 lymphedema used SSCG for 2 weeks after …

Changes In Human Resources Function In Higher Education Institutions During A Pandemic, Naterena Anevia Parham-Cofield

Walden Dissertations and Doctoral Studies

No abstract provided.

Novel Drug Approvals 2023, Emily Wagner, Christina Swiger, Mary Hoang, Maley Zents

Transformative Medicine

This article provides an overview of the novel drugs approved for 2023. The Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) provides standards to drug developers. The CDER sets standards for required data needed in the drug development and application process. Every year a variety of new drugs and biological products are approved. Some are new molecular compounds while others are structurally similar to those already on the market. Therefore, products may not have been used in medical practice previously while others have already been used in practice. This article highlights medications that are new in …

36th Annual Student Research Forum Abstract Booklet, University Of Memphis Graduate School, Helen Hardin Honors College, University Of Memphis Graduate Student Association

Annual Student Research Forums

No abstract provided.

Mothers With Disabilities As Health Navigators: Narratives Of Pregnancy, Postpartum Depression, And Parenting, Agnes Amoakwa

Theses and Dissertations

Scholars have focused on factors that affect pregnancy decisions, linking it to internal factors such as physical attachment and love towards children and feasibility of external factors, among others, while others have focused on experience with health professionals and accessibility of healthcare facilities and equipment during access to maternal care. While these studies are important, fewer focus has been placed on how women with disabilities navigate the postpartum phase of motherhood and the support needed to navigate through this experience. I employed the communicated narrative sense-making theory to explore the meanings of stories shared by mothers with disabilities about their …

The Free Press Vol. 55, Issue 9, 03-25-2024, Dakota Eddy

Free Press, The

The New FAFSA: Q&A--Games and Activities--Maine Marches for Gaza--USM Hosts Banned Book Fair with Books=A=Million--Volunteering At Preble Street--University of Southern Maine Men's Lacrosse Battles UNE Nor'easters

The Lived Experience Of Family Stress In Partners Of Firefighters During The Covid-19 Pandemic, Kimberley A. Giannini

Walden Dissertations and Doctoral Studies

No abstract provided.

Financing Reforms To Meet A Pivotal Moment In Global Health, Kevin A. Klock, Alexandra Finch, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

2024 will be the most important moment for global health since the World Health Organization’s founding in 1948, but only if states give major reforms their full political and financial backing. Bold new commitments in disease surveillance, capacity building, and more equitable access to health products cannot be achieved without ample and sustainable funding. In this essay, we discuss major reforms found in the emerging pandemic agreement and reformed International Health Regulations and then explore the significant challenges and opportunities for financing them.

Characterizing Antibiotic Regimen Modification Behavior, Patient Characteristics, And Outcomes For Patients With Gram-Negative Bacterial Infections, A Retrospective Single-Center Study, Jason Yamaki, Mirna Mikhail, Richard Beuttler, Philip Robinson, Emre Yücel, Alexandre H. Watanabe

Pharmacy Faculty Articles and Research

Few studies describe the frequency of antibiotic regimen modification behaviors in the acute care setting. We sought to ascertain patient and treatment characteristics, details of regimen modification, and clinical outcomes with antibiotic modifications. This retrospective study included patients admitted to Hoag Memorial Hospital from 1 January 2019–31 March 2021 with a complicated infection caused by a Gram-negative organism resistant to extended-spectrum cephalosporins or with the potential for resistance (AmpC producers). A total of 400 patients were included. The predominant sources were bloodstream (33%), urine (26%), and respiratory (24%), including patients with multiple sources. The most isolated organisms were Pseudomonas spp. …

The Invasive Bank Vole (Clethrionomys Glareolus); A Longitudinal Investigation Into Rodents And Their Pathogen Communities, Using The Irish Rodent Invasion As A Model System., Andrew Mcmanus

Theses

The recent emergence of zoonotic pathogens such as, SARS-CoV-2, Ebola and Mpox, have emphasised the necessity to study wildlife and their pathogens. A knowledge gap currently exists in longitudinal studies of biological invasions, which are needed to understand the change in pathogen communities caused as the invader becomes more established. The invasion of Clethrionomys glareolus in Ireland provides a unique model system to study these changes at different stages of the bio-invasion. This is due to the depauperate small mammal community in Ireland, identifiable source population, introduction point, and ongoing expansion of C. glareolus in Ireland. Extensive work has been …

Effectiveness Of Frog Skin Secretions Against Uv-B Radiation, Connor Mcgaha, Kinkade Mcmurray, Lee B. Kats

Seaver College Research And Scholarly Achievement Symposium

As an increasing number of their species face possible extinction, amphibian populations have been steadily declining over the past decades (IUCN). While various factors have been suggested or proven to be partially responsible for this reduction, increased ultraviolet B radiation (UVBR) appears to be one of the more prominent explanations, especially when considering the continual thinning of the Earth’s ozone layer due to anthropogenic climate change. However, it has also been discovered that skin secretions, which are reported to function as a component of amphibians’ innate immune systems, may have an effect on UVBR (Cramp and Franklin). With this in …

Methotrexate-Induced Pancytopenia: A Call For Mindful Medication Practices, Eunbee Cho, Jessica Marcela Daza, Jiye A. Park, Shreel Patel, Seokwon Choi, Daniel Farray

Research Symposium

Introduction: Methotrexate(MTX) is a widely used disease-modifying antirheumatic drug for various conditions including autoimmune diseases or malignancies. Pancytopenia as an adverse effect of methotrexate is rarely reported but sometimes fatal, and requires more attention. This case report shows a 76-year-old woman with a history of rheumatoid arthritis(RA) on MTX therapy, presenting with severe pancytopenia and oral lesions, and highlights the importance of safe medication practices especially in elderly patients with poor health literacy and compliance.

Case Presentation: A 76-year-old female with rheumatoid arthritis presented to the emergency department with a worsening oral lesion. She had been on an unspecified maintenance …

Jungle Fever: Navigating Malaria In Immigrant Travelers Patient At South Texas: A Case Report, Elimar Gonzalez Morales, Eunbee Cho, Jose Gomez Casanovas, Khairiya Haj-Yahya

Research Symposium

Introduction: Malaria is a severe mosquito-borne illness that can be life-threatening. This infection continues to be a significant global health concern, most prominent in tropical and subtropical regions. Malaria's clinical manifestations exhibit a striking diversity, influenced by geographical variables, the individual's immunity, and age. Diagnosing and treating malaria early is crucial to preventing severe complications and fatalities. This heterogeneity poses unique challenges to its diagnosis and treatment, making it a subject of continuous study and innovation. In this case, we present a case of a patient traveling from an endemic area to a non-endemic area. In this comprehensive examination of …

Human Blood Cell Isolation: The Critical First Step In Our Laboratory’S Immunobiology Experimental Protocals, Victor Rivero

UNO Student Research and Creative Activity Fair

HUMAN BLOOD CELL ISOLATION: THE CRITICAL FIRST STEP IN OUR LABORATORY’S IMMUNOBIOLOGY EXPERIMENTAL PROTOCALS

Victor Rivero1 Paul W. Denton1, [email protected]

1Department of Biology, University of Nebraska at Omaha, Omaha, NE

The Denton Immunobiology Laboratory focuses on enhancing human natural killer (NK) cell killing capabilities, particularly in the context of combating cancer. NK cells are immune cells that have the ability to kill diseased cells via two mechanisms: direct killing, and antibody-dependent cell-mediated cytotoxicity (ADCC). We recently published our novel approach to testing both methods of killing by using NK cells derived from the same human donor. Our testing approach allows …

A National Cross-Sectional Survey To Assess The Education And Training Needs Of Allied Health Professionals And Clinical Psychologists Delivering Rehabilitation For Children And Young People Affected By Covid-19 In The United Kingdom, Jennifer Gardner, Zoe Berger, Graeme O'Connor, Anne Gordon, Philippa Wright

Internet Journal of Allied Health Sciences and Practice

Purpose: In the paediatric population there are two conditions associated with COVID-19 infection: Paediatric Multisystem Inflammatory Syndrome (PIMS-TS) and Paediatric Long-COVID. The emerging clinical picture of children and young people (CYP) affected by COVID-19 has highlighted the vital role Allied Health Professionals (AHP’s) and clinical psychologists have in supporting rehabilitation. Therefore, it is imperative that AHP’s and Psychologists working across all clinical sectors have the knowledge, experience and training to meet the rehabilitation needs of CYP who have been affected by COVID-19. The aim of this cross-sectional survey was to explore AHPs and psychologists’ views on CYP rehabilitation needs and …

Recognizing Strokes In The Pacu In Adult Versus Pediatric Patients, Juliet Velhagen, Thomas Ferrer, Ricardo Falcon, Tim Petersen, Codruta Soneru

Brain & Behavioral Health Research Day

This poster discusses strokes in the post-anesthesia care unit in both adult and pediatric patients. We discuss stroke incidence, post-anesthesia stroke symptoms to be aware of, what symptoms overlap between adult and pediatric patients, and the importance of early stroke recognition.

Digital Twins For Health: A Scoping Review, Evangelia Katsoulakis, Qi Wang, Huanmei Wu, Leili Shahriyari, Richard Fletcher, Jinwei Liu, Luke Achenie, Hongfang Liu, Pamela Jackson, Ying Xiao, Tanveer Syeda-Mahmood, Richard Tuli, Jun Deng

Faculty, Staff and Student Publications

The use of digital twins (DTs) has proliferated across various fields and industries, with a recent surge in the healthcare sector. The concept of digital twin for health (DT4H) holds great promise to revolutionize the entire healthcare system, including management and delivery, disease treatment and prevention, and health well-being maintenance, ultimately improving human life. The rapid growth of big data and continuous advancement in data science (DS) and artificial intelligence (AI) have the potential to significantly expedite DT research and development by providing scientific expertise, essential data, and robust cybertechnology infrastructure. Although various DT initiatives have been underway in the …

Physician Assistant Students' Attitudes Toward Satisfaction And Self-Confidence In Learning Of Summative Standardized Patient Simulations In Relationship To Their Prior Healthcare Experience Hours And The Number Of Formative Assessments: A Quantitative Predictive Correlational Study, Juanita W. Skillman

Doctoral Dissertations and Projects

This quantitative, non-experimental, predictive correlational study aimed to determine if there is a relationship between the criterion variable of physician assistant students' attitudes of satisfaction and self-confidence in learning among the linear combination of the predictor variables of prior healthcare experience hours and the number of formative assessments before the summative assessment. The experiential learning theory guided this study and is valuable to physician assistant programs because the data obtained on students' perceived attitudes is crucial to improving future student simulation experiences in which competencies are measured and compared against outcomes standards set by accreditation bodies. The study included 136 …

Emulating Paul’S Ministry Leadership In A Diverse And Changing Cultural Landscape, Mark J. Lee

Doctoral Dissertations and Projects

The purpose of this Doctor of Ministry project is to train ministry leaders by studying the cross-cultural leadership characteristics of Apostle Paul. Central Steele Creek Presbyterian Church is part of the sad statistic of traditional churches that have been declining for the past thirty years. This will continue unless leaders of the church embrace the diverse culture and nature of the surrounding community. Cross-cultural leadership is needed in this time of multi-cultural communities and there is no one better than Paul to demonstrate this indispensable cross-cultural ministry paradigm. If leaders at Central are trained and motivated to embrace Paul’s cross-cultural …

The Inequitable Burden Of Infectious Diseases Among Remote-Living Aboriginal And Torres Strait Islander Australians: A Product Of History, Stephanie L. Enkel, Rebecca Famlonga, Hannah M. M. Thomas, Nina Lansbury, Jonathan R. Carapetis, Glenn Pearson, Asha C. Bowen

Journal of the Australian Indigenous HealthInfoNet

Insufficient and poorly maintained housing and plumbing in many remote Australian Indigenous communities in Australia results in reduced capacity to maintain personal hygiene, contributing to infectious disease inequalities. Infections from Streptococcus pyogenes (Strep A) and sequalae are often noted to be the result of contextual poverty; a product of over 230 years of discriminatory practice that has excluded Indigenous people from the basic human rights of healthy, maintained housing afforded to most in the nation. The solutions for eliminating diseases of inequity among Australian Indigenous population are known, their success is historically documented, and yet they are to be comprehensively …