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The Ghanaian War Against Malaria: A Geospatial Approach To Malaria And Healthcare Access In Ghana, Emmanuel Aklie

Theses

This geospatial research project aims to analyze the complex factors influencing malaria incidence in Ghana, including healthcare access, cultural beliefs, and preventive measures. Using GIS mapping and spatial analysis, the study examines malaria distribution and healthcare facility locations to identify hotspots and access inequalities. Combining quantitative data from sources like Demographic and Health Surveys with qualitative methods like surveys and interviews, the project analyzes the relationship between malaria prevalence and vaccination rates, bed net usage, and cultural views on treatment. By taking a comprehensive approach focused on evidence-based insights, the research seeks to inform targeted interventions by the Ghanaian government …

Avian Diversity And Abundance Among Agricultural Land, Forested Land, And Their Ecotone In Guadalupe, Cerro Punta, Chiriquí Province, Republic Of Panamá., Stella Rae Kinard

Independent Study Project (ISP) Collection

As the human population increases, finding the balance between modifying land use for resources and protecting areas to preserve species that are threatened by anthropogenic disturbance is an ever growing problem. Guadalupe is a town in the Western Highlands of Panamá that struggles in this balance as its primary income source is agriculture, but it is located on the border of two protected areas, Parque Nacional La Amistad and Parque Nacional Volcán Barú. By understanding the unique ways in which avifauna utilize distinct vegetative landscapes, recommendations can be made for management styles of farms in Guadalupe to implement practices that …

A Physiological Approach To Renal Clearance: From Premature Neonates To Adults, Nick Holford, Conor J. O'Hanlon, Karel Allegaert, Brian Anderson, Amilcar Falcão, Nicolas Simon, Yoke Lin Lo, Alison H. Thomson, Catherine M.T. Sherwin, Evelyne Jacqz-Aigrain, Carolina Llanos-Paez, Stefanie Hennig, Linas Mockus, Carl Kirkpatrick

Pediatrics Faculty Publications

Aims: We propose using glomerular filtration rate (GFR) as the physiological basis for distinguishing components of renal clearance. Methods: Gentamicin, amikacin and vancomycin are thought to be predominantly excreted by the kidneys. A mixed-effects joint model of the pharmacokinetics of these drugs was developed, with a wide dispersion of weight, age and serum creatinine. A dataset created from 18 sources resulted in 27,338 drug concentrations from 9,901 patients. Body size and composition, maturation and renal function were used to describe differences in drug clearance and volume of distribution. Results: This study demonstrates that GFR is a predictor of two distinct …

Functional And Multi-Omics Effects Of An Optimized Crispr-Mediated Furin Depletion In U937 Monocytes, Ruiming Chua, Lijin Wang, Roshni Singaraja, Sujoy Ghosh

Division of Basic Science Faculty Publications

The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases. Previously, we performed a systemic inhibition of FURIN in a mouse model of atherosclerosis and demonstrated significant plaque reduction and alterations in macrophage function. To understand the cellular mechanisms affected by FURIN inhibition in myeloid cells, we optimized a CRISPR-mediated gene deletion protocol for successfully deriving hemizygous (HZ) and nullizygous (NZ) FURIN knockout clones in U937 monocytic cells using lipotransfection-based procedures and a dual guide RNA delivery strategy. We observed differences in monocyte and macrophage …

Real-Time Feedback For Hand Hygiene, Joo Ran Park

MSN Student Capstones

No abstract provided.

Hyperbaric Oxygen Treatment For Diabetic Foot Wounds, Holly Nestlerode

MSN Student Capstones

No abstract provided.

Penicillin Allergy De-Labeling: Evaluating A Health System’S Implementation Of The Pen-Fast Tool Within An Infectious Disease Clinic., Jennifer Mccarthy Pharmd, Ms

Pharmacy Residency

Presented at the Great Lakes Pharmacy Residents Conference. West Lafayette, IN: April 2024.

This retrospective, post-implementation study found that 81% of patients with a documented penicillin allergy could be de-labeled, and that the majority could theoretically tolerate a penicillin challenge.

Identifying Improvement Opportunities For The Utilization Of Carbapenems At A Community Health System., Kendra Yarian Pharmd

Pharmacy Residency

Presented at the Great Lakes Pharmacy Resident Conference. West Lafayette, IN: April 2024.

This study found opportunities to improve utilization of carbapenems, such as by delabeling inappropriate penicillin and cephalosporin allergies, modifying order sets, providing education, and initiating alerts to prompt de-escalation.

The Witch-Hunt For Spies - A Critique Of The China Initiative And National Security’S Outsized Influence In Equal Protection Analysis, Winni Zhang

Washington and Lee Journal of Civil Rights and Social Justice

The U.S. Government has increased its focus on Chinese espionage in the last decade in a randomized and unpredictable way. Primarily targeting Chinese scientists and academics, the “China Initiative” has resulted in widespread targeting of individuals based on their race, ethnicity, and national origin. The program was formally terminated and said to now be a part of a broader approach to nation-state threats. However, the outcomes and effect of the economic espionage charges in the last 15 years has greatly skewed towards prosecuting Chinese individuals irrespective of the name of the program. While protections typically exist in the law to …

A Multi-Ancestry Genetic Study Of Pain Intensity In 598,339 Veterans., Sylvanus Toikumo, Rachel Vickers-Smith, Zeal Jinwala, Heng Xu, Divya Saini, Emily E Hartwell, Mirko Pavicic, Kyle A Sullivan, Ke Xu, Daniel A Jacobson, Joel Gelernter, Christopher T Rentsch, Million Veteran Program, Eli Stahl, Martin Cheatle, Hang Zhou, Stephen G Waxman, Amy C Justice, Rachel L Kember, Henry R Kranzler

Epidemiology and Environmental Health Faculty Publications

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids had a central role in precipitating the opioid crisis. Despite an estimated heritability of 25-50%, the genetic architecture of chronic pain is not well-characterized, in part because studies have largely been limited to samples of European ancestry. To help address this knowledge gap, we conducted a cross-ancestry meta-analysis of pain intensity in 598,339 participants in the Million Veteran Program, …

From Healing To Happiness, Lauren Hannah

Interior Design Capstones

Animal shelters play a crucial role in providing care and rehabilitation for stray or abandoned dogs. However, there is a growing understanding that rethinking the conventional role of animal shelters can lead to significant improvements in the lives of dogs through specialized behavioral therapy and rehabilitation programs. By implementing these programs, shelters have the potential to regenerate and transform dogs’ lives, enabling them to overcome behavioral challenges and increasing their chances of finding loving adoptive homes.

The focus of these initiatives is to heal and nurture the dogs’ behaviors, addressing underlying issues that may have contributed to their arrival in …

Benefits Of A Community Reentry Intervention For Reentry Self-Efficacy In Homeless Shelter Residents With Past Incarceration, Kathryn E. Hurley

Honors Theses

The U.S. has one of the highest levels of incarceration and recidivism in the world (American Civil Liberties Union, 2022; U.S. Department of Justice, n.d). Several factors contribute to recidivism, including the loss of monetary funds and loss of housing upon incarceration. Homelessness especially predicts recidivism. It has been found to increase the risk of recidivism by almost 50% (Jacobs & Gottlieb, 2020). Within the context of a long-term ongoing participatory community action research Project in homeless shelters (Reeb et al., 2024), this study examined the benefit of reentry support sessions within the homeless shelter environment, with an attempt to …

Adoption Of Ventilator-Associated Event Bundle In Adult Critical Care Population, Renee Christine Hayes

Doctor of Nursing Practice Scholarly Projects

Problem: The utilization of mechanical ventilatory support is a periodic necessity within critical care. One significant aspect of mechanical ventilatory health management focuses on preventing the sequela of ventilator-associated events (VAE). The societal impact of VAE occurrences weighs heavily on the already burdened registered nurse (RN), health care providers including physicians and advanced practice providers, healthcare system, and overall patient and family wellbeing. Purpose: This project examined if the addition of a ventilator associated event bundle (VB) reduces the occurrence of VAE within the adult patient population requiring mechanical ventilation for longer than 48 hours. Methods: Metric review of VAE …

Russia In A Changing Climate, Debra Javeline, Robert Orttung, Graeme Robertson, Richard Arnold, Andrew Barnes, Laura Henry, Edward Holland, Mariya Omelicheva, Peter Rutland, Edward Schatz, Caress Schenk, Andrei Semenov, Valerie Sperling, Lisa Mcintosh Sundstrom, Mikhail Troitskiy, Judith Twigg, Susanne Wengle

Political Science

Climate change will shape the future of Russia, and vice versa, regardless of who rules in the Kremlin. The world's largest country is warming faster than Earth as a whole, occupies more than half the Arctic Ocean coastline, and is waging a carbon-intensive war while increasingly isolated from the international community and its efforts to reduce greenhouse gas emissions. Officially, the Russian government argues that, as a major exporter of hydrocarbons, Russia benefits from maintaining global reliance on fossil fuels and from climate change itself, because warming may increase the extent and quality of its arable land, open a new …

Rocscholar Annual Report 2023, Lisa M. Buda

Rochester Regional Health authored publications and proceedings

RocScholar is the institutional repository (IR) for Rochester Regional Health (RRH) and is managed by the Libraries at RRH. It provides storage and access for RRH’s research and scholarly activity. This report highlights the repository’s third year of implementation.

The Role Of Acgme-International In Enhancing Opportunities Of Residents For Advanced Subspecialty Training, James A. Arrighi, Lorraine C. Lewis, Thomas J. Nasca

Department of Medicine Faculty Papers

No abstract provided.

Oral Screening Protocol Program: A Doctor Of Nursing Practice Project, Nina Tran Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Background: An increasing lack of compliance by Registered Nurses (RN) to perform oral health assessments leads to detrimental health concerns. Despite increase of evidence regarding abnormalities, compliance performing health exams are still compromised. Inpatient medical surgical progressive care unit (MSPCU) are even more compromised due to the patient’s comorbidities. Measures to optimize oral health performed by RNs could decrease oral health detriments.

Objectives: The purpose of this project was to develop, implement, and evaluate a program in order to improve oral care by RNs and identify the abnormalities assessed. The primary aim of this project was to implement …

Wooster Magazine: Spring 2024, Caitlin Paynich Stanowick

Wooster Magazine: 2021-2030

The Wooster magazine spring 2024 issue features alumni who translated campus exploration at The College of Wooster to empowered leadership in their next communities. Whether they are musicians performing as an ensemble, teammates on an athletic field, neighbors in the international house, study partners in the science labs, moot court team members, or otherwise connected, Wooster students find and create community on campus. Constructing these relationships and exploring all the opportunities that contribute to a Wooster education sends forward alumni with strengths that guide them as they serve their next communities around the world. The spring 2024 issue of Wooster …

Transcriptional Signature Of Durable Effector T Cells Elicited By A Replication Defective Hcmv Vaccine, Xiaohua Ye, David J H Shih, Zhiqiang Ku, Junping Hong, Diane F Barrett, Richard E Rupp, Ningyan Zhang, Tong-Ming Fu, W Jim Zheng, Zhiqiang An

Faculty, Staff and Student Publications

Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects and the most common opportunistic infection that causes life-threatening diseases post-transplantation; however, an effective vaccine remains elusive. V160 is a live-attenuated replication defective HCMV vaccine that showed a 42.4% efficacy against primary HCMV infection among seronegative women in a phase 2b clinical trial. Here, we integrated the multicolor flow cytometry, longitudinal T cell receptor (TCR) sequencing, and single-cell RNA/TCR sequencing approaches to characterize the magnitude, phenotype, and functional quality of human T cell responses to V160. We demonstrated that V160 de novo induces IE-1 and pp65 specific durable polyfunctional …

Novel Insights Into The Autoimmune Mechanisms In Coxsackievirus B Infections And Their Prevention By Vaccination, Mahima Theresa Rasquinha

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Coxsackievirus Bs (CVBs) are RNA viruses of the genus Enterovirus belonging to the Picornaviridae family. CVBs commonly infect humans, and multiple CVB types can induce similar diseases such as myocarditis, pancreatitis, and type 1 diabetes (T1D). Although CVB infections can lead to the generation of autoantibodies, their role in disease is poorly defined, and vaccines are not available to prevent or minimize these infections. To fill these gaps, we first analyzed the autoantibody repertoire in mice infected with CVB3 by Phage ImmunoPrecipitation Sequencing (PhIP-Seq) and identified autoantibodies for several novel antigens not previously reported. The data were validated using enzyme-linked …

Crispr, Omega, And Fanzor: Mixed Blessings Of Genome Editing Technology, Haeun Tae

Senior Honors Theses

A little more than a decade ago, CRISPR-Cas system was identified as a potential gene editing tool. This RNA-guided DNA cleavage system, which naturally provides immunity to the prokaryotic host cell, has been engineered since for its application in agriculture, genomic screening, and hereditary genetic disorder treatment and cures. Recently, a eukaryotic CRISPR-Cas-like system, Fanzor, was reported, under a new class of the RNA-guided system (termed OMEGA). The discovery has increased the potentials of genetic modification more than ever, while simultaneously increasing the need for ethical considerations and guidelines. The history, structure, and functions of the two RNA-guided systems, as …

Intensive English Program Design For Minnesota Public School District, Ellen Bialka

Capstone Collection

The recent rise in undocumented immigrants in Minnesota has brought to light significant demographic shifts within the state. Many individuals in this population have limited or no proficiency in English, which highlights the challenges immigrant communities face in adapting to their new linguistic surroundings. As a result, educators have been presented with the challenge of serving a growing number of immigrant children in their schools. To tackle this issue, an intensive English program was developed for a suburban public school district in Minnesota to offer a more targeted approach to improving English proficiency among students before beginning courses required for …

2024 Medical Student Research Day Abstracts, George Washington University

GW Research Showcase 2021-2026

The George Washington University School of Medicine & Health Sciences research showcase is designed to highlight the breadth of research and scholarly activity that students have accomplished during their education at The GW School of Medicine & Health Sciences. All students are invited to present research regardless of the area of focus. Abstract submissions represent a broad range of research interests and disciplines, including basic and translational science, clinical research, health policy and public health research, and education-related research.

Social Determinants Of Health And Internalized Hiv Stigma Among People Living With Hiv In South Florida: An Intersectional Approach, Megan A. Jones Mph, Elliott R. Weinstein Mph, M.S., Steven A. Safren Ph.D.

GW Research Showcase 2021-2026

No abstract provided.

2024 Medical Student Research Day Abstracts, George Washington University

GW Research Showcase 2021-2026

Medical student research day is designed to highlight the breadth of research and scholarly activity that medical students have accomplished during their education at The GW School of Medicine and Health Sciences. All medical students are invited to present research regardless of the area of focus. Abstract submissions represent a broad range of research interests and disciplines, including basic and translational science, clinical research, health policy and public health research, and education-related research.

Optimizing Malaria Control: Granular And Cost-Effective Mosquito Habitat Index In Endemic Areas Through Satellite Imagery, Nur Ainun Daulay, Salwa Rizqina Putri, Arie Wahyu Wijayanto, Ika Yuni Wulansari

Knowledge Engineering and Data Science

Malaria, classified as a tropical disease under the Sustainable Development Goals (SDGs) indicator 3.3, remains a significant global health challenge. In this study, by taking advantage of multiple spectral composite indexes of multisource satellite imagery to capture various geospatial features relevant to the suitability of marsh mosquito habitat, we introduced the Mosquito Habitat Suitability Index (MHSI) to assess potential Anopheles mosquito breeding sites in terms of the vegetation density, water bodies, environment temperature, and humidity in any particular areas. The MHSI integrates the publicly accessible granular level of the normalized difference vegetation index, water index, land surface temperature, and moisture …

Teaching Global Health Law: Preparing The Next Generation For Future Challenges, Lawrence O. Gostin, Sarah L. Bosha, Benjamin Mason Meier

Georgetown Law Faculty Publications and Other Works

Following from sweeping law reforms across the global health landscape, there is a need to prepare the next generation to advance global health law to ensure justice for a healthier world. Educational programs across disciplines have increasingly incorporated the field of global health law, with new courses examining the law and policy frameworks that apply to the new set of public health threats, non-state actors, and regulatory instruments that structure global health. Such interdisciplinary training must be expanded throughout the world to prepare future practitioners to strengthen global health law — ensuring a foundation for global health in legal studies …

Poets Rooted In Nature: An Ecopoetry Anthology, Ian Chen , '24, Winston Zhang , '27, Riya Rao , '26, Peter Schmidt

English Literature Faculty Works

Anyone who has studied poetry has experienced its elusiveness as well as the profound impact that it brings upon its readers. Although poetry comes in many shapes and forms, the universal theme among impactful poetry is its ability to both evoke powerful emotions and inspire readers to action. In the somewhat bleak time of the present, individuals can easily feel insignificant among the masses; however, poetry can inspire wonder and break readers away from the screens and fickle distractions ever present in the modern world. In this anthology, we focus on the multifaceted genre of ecopoetry, a genre of poetry …

Identifying The Effects Of Environmental Conditions On Listeria Monocytogenes Fitness And Pathogenesis Modified By Transcription Factor Cody, Elizabeth K. Herr

Honors Theses

Listeria monocytogenes is a pathogen with the capability of causing severe illness in individuals who consume contaminated foods. Many foods have been found to harbor the bacterium, but dairy products, produce, and other prepackaged foods are particularly susceptible to contamination. Contaminated foods are exposed to a variety of environmental conditions during packaging, processing, consumption, and digestion, all of which play an essential role in modulating the survival and pathogenesis of L. monocytogenes. Conditions of particular interest include cold storage, presence of food additives, and activity of antimicrobial enzymes such as lysozyme. My honors thesis research has focused on elucidating how …

Dipl 6277 Global Health, Bioterrorism, And International Security, Yanzhong Huang Phd

Diplomacy Syllabi

This course is an interdisciplinary survey that focuses on the issues of global health security. As shown in the COVID-19 pandemic, international trade and travel threaten epidemics by transporting and spreading infectious disease globally at jet speed. The growing risk of exposure to infectious diseases, coupled with the threat of intentional release of dangerous pathogens, creates a situation in which health and security are interacting with greater frequency and intensity. This development parallels efforts to redefine the concept of security to encompass new global challenges such as noncommunicable diseases (NCDs). To what extent does health fit this new security agenda? …