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Designing Thermostable Hermes Lipopolyplex Nanoparticles For Mrna And Synthetic Hpdna Delivery, Amy Walker, Gözde Tezcan, Hassan Idris, Matthew Walker, Ashish Dhir

Delivery Of Nucleic Acid Therapeutics II: Biology, Engineering And Development

Please click Additional Files below to see the full abstract.

Sub-Saharan Africa’S Handling Of Covid-19 Pandemic: Rwanda Versus Tanzania, Luke D. Baumel

Honors Undergraduate Conference

How has the Covid-19 outbreak in early 2020 and the pandemic that followed been handled in Sub-Saharan Africa? What was done well and what was done poorly and why? What are the implications of the way it was handled? These questions and more are answered throughout this paper, using Rwanda as an example of a Sub-Saharan African country who handled it relatively well and neighboring Tanzania as an example of a Sub-Saharan African country that mishandled the outbreak and pandemic. In early 2021, most Sub-Saharan African countries had been afflicted by Covid-19 at a relatively lower rate than many Western …

Gut Microbial Dysbiosis Differs In Two Distinct Cachectic Tumor-Bearing Models Consuming The Same Diet, Lauri O. Byerley, Brittany Lorenzen, Hsiao Man Chang, William G. Hartman, Michael J. Keenan, Ryan Page, Meng Luo, Scot E. Dowd, Christopher M. Taylor

School of Medicine Faculty Publications

The impact of cancer cachexia on the colonic microbiota is poorly characterized. This study assessed the effect of two cachectic-producing tumor types on the gut microbiota to determine if a similar dysbiosis could be found. In addition, it was determined if a diet containing an immunonutrient-rich food (walnuts) known to promote the growth of probiotic bacteria in the colon could alter the dysbiosis and slow cachexia. Male Fisher 344 rats were randomly assigned to a semi-purified diet with or without walnuts. Then, within each diet group, rats were further assigned randomly to a treatment group: tumor-bearing ad libitum fed (TB), …

Health Care Professionals’ Stigma Toward People With An Opioid Use Disorder: Preliminary Findings On The Effect Of Amount Of Contact Has On Stigma, Gabriela Murza, Cris Meier, Lily Ward, Sydney O'Shay, Rachel Myrer

Transforming Communities

Opioid-related deaths are the leading cause of injury deaths in Utah. Individuals who seek treatment for opioid misuse report stigma from healthcare professionals as the leading barrier to accessing treatment. Health professionals provide a variety of treatment options in efforts of combating high rates of opioid misuse. However, these professionals may not be properly trained in stigma reduction strategies, thus leading to poor client care and outcomes. The current study examined the association between contact with individuals who misuse opioids and stigma perceptions among healthcare professionals. A one-time survey was administered to healthcare professionals who practice in Utah using convenience …

Birthing Contention: Conflict Between Black And White Health Officials In Southern Midwife Training In The Mid-Twentieth Century, Ruth Hyde Truman

The Thetean: A Student Journal for Scholarly Historical Writing

"You can go right now and start talking to somebody about my age and Iil older and quite a bit older. They'll say, 'I was delivered by a granny midwife.' A black woman, a granny midwife." These words, spoken by Onnie Lee Logan in her book, Motherwit: An Alabama Midwife's Story, illustrate the important role that black women played in childbirth in the South in the mid-twentieth century. In the South, hospitals were located far from rural communities, and women were much more likely to give birth in their own homes and enlist the aid of a black midwife than …

Candida Parapsilosis Endocarditis In A Patient With Mitral Valve Clip Receiving Chronic Fluconazole Therapy, Shahnawaz Notta, Ashwin Jagadish, Nasir Notta, Hezborn Magacha, Sean Moore, Sabahuddin Hajjar, Joel Danisi, Mohannad Al Akeel

Appalachian Student Research Forum

Introduction Fungal endocarditis (FE) is a relatively uncommon and challenging form of endocarditis, making up a modest percentage of infectious endocarditis cases, ranging from 1.3% to 6%.1 While Candida albicans has historically been recognized as a common causative agent, the landscape is evolving, with Candida parapsilosis (C. parapsilosis) emerging as a prevalent non-albicans species associated with this condition. Recent data show FE prevalence rising to 2-5% of endocarditis cases, highlighting evolving epidemiology. We present a rare case of C. parapsilosis endocarditis, contributing to understanding the changing fungal pathogen landscape in cardiovascular infections. By highlighting this unique instance of Candida parapsilosis …

Dried Saliva Spot As An Effective Tool In The Diagnosis And Management Of Chronic Disease., Naveen Chaurasia, Ankit Jain, Nitin Dubey

The Thai Journal of Pharmaceutical Sciences

In recent decades, there has been significant progress in non-invasive sampling techniques, which serve as effective tools in treating and managing various chronic diseases. Among these techniques, dried saliva spot (DSS) sampling of human saliva has emerged as a prominent alternative to serum for detecting targeted molecules. The diagnostic potential of saliva has been extensively studied, highlighting its applicability across a spectrum of diseases. In addition to DSS, other sampling methods, such as dried plasma spots, dried blood spots, and dried matrix spots, have been explored. Various types of filter papers have been employed in DSS sampling procedures, with notable …

Exploring Attitudes Toward Pre-Exposure Prophylaxis For Hiv Prevention Prior To Implementation Among Female Sex Workers In Malaysia: Results From A Qualitative Study, Shaylen Foley, Danya E. Keene, Roman Shrestha, Shan-Estelle Brown, Kamal Gautam, Ryan A. Sutherland, Francesca Maviglia, Rumana Saifi, Jeffrey A. Wickersham

Faculty Publications

No abstract provided.

Swiss Cheese Heart: A Tale Of Multiple Valve Perforations, Hussam Al Hennawi, Shayan I. Khan, Aamna Khan, Usama Sadiq, Sung-Hae Cho

Abington Jefferson Health Papers

Gerbode defect, an anomalous connection between the left ventricle and right atrium, is often congenital but can be acquired or iatrogenically formed. We present an exceedingly rare case of this defect associated with multiple valve perforation in an otherwise healthy patient with bicuspid aortic valve and endocarditis.

The Dearth Of Knowledge Of Health Insurance Literacy Within The United States, Katherine A. Conzet

Honors Thesis

This literature review and cross-comparison were conducted to combine resources that bring to light the lack of knowledge on health insurance, the impact of this low health insurance literacy (HIL), and the lack of research being done in this subject field. This thesis analyzes and compares different research that measures HIL levels and compares these findings. At the same time, this thesis presents the complex history of health insurance and how this understanding can contribute to lower population HIL and proposes different ways to accurately measure HIL. The purpose is to show the necessity for more research into the field …

Covid-19 Vaccination In Patients With Inborn Errors Of Immunity Reduces Hospitalization And Critical Care Needs Related To Covid-19: A Usidnet Report, John Mcdonnell, Kimberley Cousins, M. Elizabeth M. Younger, Adam Lane, Hassan Abolhassani, Roshini S. Abraham, Salem Al-Tamemi, Juan Carlos Aldave-Becerra, Eman Hesham Al-Faris, Alberto Alfaro-Murillo, Suzan A. Alkhater, Nouf Alsaati, Alexa Michelle Altman Doss, Melissa Anderson, Ernestina Angarola, Barbara Ariue, Danielle E. Arnold, Amal H. Assa'ad, Caner Aytekin, Meaghan Bank, Jenna R.E. Bergerson, Jack Bleesing, John Boesing, Carolina Bouso, Nicholas Brodszki, Diana Cabanillas, Carol Cady, Meghan A. Callahan, Luke Wall, Et Al

School of Medicine Faculty Publications

BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. RESULTS: Physicians entered data on 1245 patients from 24 countries. The most …

Predictors Of Prep Uptake By Black Gay And Bisexual Men In Ohio, Ade Elisha

Walden Dissertations and Doctoral Studies

No abstract provided.

Spatial Behavior Of Hospital Visits By Hand, Foot, And Mouth Disease Patients In Nanchang, China, Zeliu Zheng

LSU Doctoral Dissertations

Hand foot mouth disease (HFMD) is one of the widespread transmissible diseases that target preschool children, especially in urban regions in East Asia. Understanding the travel patterns of the HFMD patients helps us understand how the spatial behaviors of patients vary across space and what are the underlying forces. It is essential for understanding the healthcare market and planning for resource allocation. Foremost, health behavior and outcome change significantly across geographic regions of various urbanicities (i.e., degrees of urbanization) due to the uneven distribution of healthcare resource. In addition, health studies in the U.S. often use hospital service areas (HSAs) …

Using Systems Thinking Tools To Inform The Implementation Of A Cysticercosis Control Program In Rural Peru, Lisset M. Dumet Poma Mba, Angela Spencer Phd, Ruth Atto Bsc, Vanessa Cruz Bsc, Percy Vilchez Mph, Seth O'Neal Md, Mph For The Cysticercosis Working Group In Peru

OHSU-PSU School of Public Health Annual Conference

Cysticercosis is an infectious disease responsible for 30-40% of acquired epilepsy in endemic areas such as rural Peru. Ring Treatment (RT) is a community-engaged cysticercosis control strategy, shown to be efficacious when delivered by research teams. We applied the Consolidated Framework for Implementation Research with additional constructs compatible with low-resource contexts in the formative evaluation to develop a protocol for implementing RT.

We included small, medium, and large municipal districts from northern Peru representing different rural primary health delivery settings. We collected 169 semi-structured and 341 network interviews. We applied Social-Network-Analysis to identify key players, roles, and collaborations to inform …

Aurora Scientific Day, 2005, Advocate Health - Midwest

Historical Documents - Combined

Aurora Health Care, Milwaukee, WI: Program for the May 5, 2005 Aurora Scientific Day. Includes an agenda and abstracts for the event.

Effectiveness Of Wellness Programs For Correctional Officers, Robert Salvatore Petralia

Walden Dissertations and Doctoral Studies

No abstract provided.

Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba

Biomedical Engineering ETDs

Since its introduction, vaccination has improved health outcomes tremendously. However, modern vaccination efforts are still difficult to implement, particularly in developing countries with warm climates. This includes complex and expensive cold-chain management of vaccines to maintain stability, a lack of medical personnel to administer parental vaccines, and needle phobia. As an alternative, dissolvable microneedles have recently been studied for their simple and painless application. In this thesis, I present a novel manufacturing process for polymer-based dissolvable microneedles, loaded with virus-like particles vaccines conjugated to TRIO or Sialokinin peptides to target malaria and arboviruses, respectively. We have performed multiple characterization studies …

Characterizing The Roles Of Bacterial And Viral Agents In House Crickets (Acheta Domesticus) At Commercial Rearing Facilities In The United States, Kimberly L. Boykin

LSU Doctoral Dissertations

Feeder insects, and in particular crickets, are becoming more popular as food for humans and domesticated animals. However, disease outbreaks continue to decimate commercial populations. The goals of this dissertation were to characterize the epidemiology of different viral and bacterial pathogens affecting the survival of European house crickets (Acheta domesticus) being raised under mass rearing conditions and identify methods to reduce the impact of these pathogens.

Crickets from nine different producers across the United States were sampled during different seasons to better estimate the prevalence of three pathogenic viruses: Acheta domesticus densovirus (AdDV), Acheta domesticus volvovirus (AdVVV), and …

Reducing Inoculum Effect By Modulating Growth Productivity Through The Superpathway Of Purine, Pyrimidine And Histidine Synthesis In Escherichia Coli, Ruth Thomas, Daniella M. Hernandez, Melissa Marzouk

Undergraduate Student Symposium

Antibiotic overuse has driven the evolution of multiple antibiotic-resistant bacteria that complicate infections that were once easily treatable. While mechanisms by which individual bacterium resist or tolerate antibiotics are well explored, less studied are the mechanisms by which populations of bacteria tolerate antibiotics as a collective. One such mechanism bacteria employ to tolerate antibiotic treatment as a collective is the inoculum effect (IE). We recently discovered that growth productivity, which describes the relationship between ATP production and growth rate, can account for IE for multiple antibiotics and pathogens. However, the underlying pathways for determining growth productivity have yet to be …

Impact Of Official State Messaging On Covid-19 Infection And Death Rates In Five U.S. States, Barclay Randall Murphy

Walden Dissertations and Doctoral Studies

No abstract provided.

The Outcome In Pediatric Acute Myeloblastic Leukemia; Results Of The First-Line Treatment And Contribution Of Hematopoietic Stem Cell Transplantation To Survival Of Relapsed Patients, Nazan Sarper, Intzi Tachzin, Sema Aylan Gelen, Emine Zengi̇n

Turkish Journal of Medical Sciences

Background/aim: To analyze the long-term outcome of pediatric patients with acute myeloblastic leukemia.Materials and methods: Data from 69 patients 0–18 years of age diagnosed between December 2001 and October 2019 were analyzed in April 2023. Patients received MRC-AML10 chemotherapy (2ADE+MACE+MidAC). No maintenance chemotherapy or preventive cranial radiotherapy was administered. Twelve patients with Down syndrome and 15 patients with promyelocytic leukemia were in the cohort. Patients with Down syndrome received reduced chemotherapy (cumulative anthracycline 420 mg/m2, cytarabine 3.4 g/m2, etoposide 1400 mg/m2). ATRA was added to chemotherapy in promyelocytic leukemia.Results: Four patients (5.8%) died in the induction (two typhlitis, one intracranial …

Midweek Memo, Georgia Southern University

Midweek Memo

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Meat Consumption Meets Risk Regulation In The United States, Andrew Kelbley

Duke Environmental Law & Policy Forum

No abstract provided.

Swine Influenza A Virus: Challenges And Novel Vaccine Strategies, Erika M. Petro-Turnquist, Matthew J. Pekarek, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Swine Influenza A Virus (IAV-S) imposes a significant impact on the pork industry and has been deemed a significant threat to global public health due to its zoonotic potential. The most effective method of preventing IAV-S is vaccination. While there are tremendous efforts to control and prevent IAV-S in vulnerable swine populations, there are considerable challenges in developing a broadly protective vaccine against IAV-S. These challenges include the consistent diversification of IAV-S, increasing the strength and breadth of adaptive immune responses elicited by vaccination, interfering maternal antibody responses, and the induction of vaccine-associated enhanced respiratory disease after vaccination. Current vaccination …

Oncogenic Oral Human Papillomavirus Clearance Patterns Over 10 Years, Gypsyamber D'Souza, Sakshi R Tewari, Tanya Troy, Jennifer Webster-Cyriaque, Dorothy J Wiley, Cecile Delille Lahiri, Frank Joseph Palella, Maura L Gillison, Howard D Strickler, Linda Struijk, Tim Waterboer, Ken Ho, Jennafer Kwait, Jason Lazar, Kathleen M Weber, Carole Fakhry

Faculty, Staff and Student Publications

Background: Effective screening for oropharyngeal cancer is lacking. Four oncogenic HPV clearance definitions were explored to understand long-term natural history for persistent oncogenic oral HPV (oncHPV), the precursor of oropharyngeal cancer.

Methods: Prospective multicenter cohort of participants living with/at-risk for HIV, with oral rinse and gargle samples collected every 6 to 12 months for up to 10 years and tested for oncHPV. HPV clearance definitions included 1 (clear1), 2 (clear2), 3 (clear3) consecutive negatives, or being negative at last two visits (clearlast).

Results: Median time to clearance of oncHPV exceeded 2 years for conservative definitions (clear3: 2.38, clearlast: 2.43), but …

The Role Of Dna Methylation And Parental History On Wheezing Trajectories In Children, Donald Eugene Warden

Electronic Theses and Dissertations Archive

Asthma and wheezing present public health changes that manifest during early childhood. This dissertation utilizes longitudinal data within the Isle of Wight Birth Cohort (IOWBC) third generation to explore the development of early childhood wheezing phenotypes, their implications for asthma development, including environmental and epigenetic factors. Children in the F2-generation (n=611) of the IOWBC were followed-up at 3, 6, 12, 24, 36, and 72 months, and the incidence of wheeze subtype (general, infectious, and non-infectious) were used in group-based trajectory models to identify phenotypes of early childhood wheezing. These trajectories were examined as predictors of asthma diagnosis, lung function, and …

Harnessing Rna Technology To Advance Therapeutic Vaccine Antigens Against Chagas Disease, Chiara Mancino, Jeroen Pollet, Assaf Zinger, Kathryn M Jones, Maria José Villar, Ana Carolina Leao, Rakesh Adhikari, Leroy Versteeg, Rakhi Tyagi Kundu, Ulrich Strych, Federica Giordano, Peter J Hotez, Maria Elena Bottazzi, Francesca Taraballi, Cristina Poveda

Center for Medical Ethics and Health Policy Staff Publications

Chagas disease (CD) (American trypanosomiasis caused by Trypanosoma cruzi) is a parasitic disease endemic in 21 countries in South America, with increasing global spread. When administered late in the infection, the current antiparasitic drugs do not prevent the onset of cardiac illness leading to chronic Chagasic cardiomyopathy. Therefore, new therapeutic vaccines or immunotherapies are under development using multiple platforms. In this study, we assessed the feasibility of developing an mRNA-based therapeutic CD vaccine targeting two known T. cruzi vaccine antigens (Tc24—a flagellar antigen and ASP-2—an amastigote antigen). We present the mRNA engineering steps, preparation, and stability of the lipid …

A Data Browsing Application For Accessing Gene And Module-Level Blood Transcriptome Profiles Of Healthy Pregnant Women From High- And Low-Resource Settings., Darawan Rinchai, Tobias Brummaier, Alexandra A Marr, Tanwir Habib, Mohammed Toufiq, Tomoshigue Kino, François Nosten, Souhaila Al Khodor, Annalisa Terranegra, Rose Mcgready, Basirudeen Syed Ahamed Kabeer, Damien Chaussabel

Faculty Research 2024

Transcriptome profiling data, generated via RNA sequencing, are commonly deposited in public repositories. However, these data may not be easily accessible or usable by many researchers. To enhance data reuse, we present well-annotated, partially analyzed data via a user-friendly web application. This project involved transcriptome profiling of blood samples from 15 healthy pregnant women in a low-resource setting, taken at 6 consecutive time points beginning from the first trimester. Additional blood transcriptome profiles were retrieved from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) public repository, representing a cohort of healthy pregnant women from a high-resource setting. …

Analisis Spasial Faktor Risiko Difteri Di Provinsi Lampung Tahun 2022 Dan 2023, Nada Izzata Kamilla, Feranita Utama, Noviani Noviani

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Difteri merupakan penyakit menular yang disebabkan oleh bakteri Corynebacterium diphtheriae. Bila ditemukan satu kasus difteri di suatu wilayah maka dapat ditetapkan sebagai KLB. Provinsi Lampung terus mengalami kenaikan kasus dan suspek difteri sejak 2020 dan turut menyumbang angka kematian akibat difteri pada tahun 2023. Kasus difteri dipengaruhi oleh beberapa faktor risiko. Penelitian ini bertujuan untuk mendapatkan gambaran distribusi dan faktor risiko kasus difteri di Provinsi Lampung dengan memetakan kabupaten/kota berdasarkan persebaran dan faktor risikonya. Penelitian ini menggunakan desain studi ekologi dengan metode deskriptif analitik dengan aplikasi Quantum GIS versi 3.28.3. Hasil menunjukan distribusi kejadian difteri di Provinsi …

Sistem Monitoring Dan Evaluasi Serta Perkembangan Program Pencegahan Dan Pengendalian Penyakit Tuberkulosis Di Dinas Kesehatan Kota Depok, Supriyanti Supriyanti, Tiur Febrina Pohan, Kemal N. Siregar

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Beban kasus TB tertinggi tahun 2021 terjadi di Provinsi Jawa Barat, Jawa Timur, Jawa Tengah, Sumatera Utara, dan DKI Jakarta. Kota Depok merupakan salah satu penyumbang beban TB di Jawa Barat. Dari data estimasi beban TB se-Provinsi Jawa Barat, Kota Depok berada di urutan ke-7 dengan estimasi jumlah kasus sebanyak 3853 kasus. Menurut indikator angka keberhasilan pengobatan pasien TB, semua kasus tahun 2018-2021 masih dibawah target 90%. Tujuan penelitian ini untuk mengetahui hasil monitoring dan evaluasi program TB yang telah berjalan di Seksi Pencegahan dan Pengendalian Penyakit Menular serta perkembangan program TB dilihat dari capaian indikator TB di Dinas Kesehatan …