Digital Commons Network^™

Psychological Experiences Of Medical-Surgical Nurses Who Cared For Covid-19 Patients., Cecilia Dapilah

Walden Dissertations and Doctoral Studies

: The outbreak of COVID-19 caused unparalleled pressure that brought healthcare facilities and healthcare staff to their knees across the globe, causing multiple deaths and economic despondency. Several studies have documented the effects of COVID-19 on healthcare workers and facilities, but none have addressed the problem from the psychological perspectives of medical-surgical nurses, especially in developing countries. This study explored the psychological experiences of medical-surgical nurses who cared for COVID-19 patients in developing countries. The theoretical foundation that informed this study was the Schachter-Singer’s theory of emotions. A descriptive qualitative design used purposeful sampling to interview 10 medical-surgical nurses. Their …

Community-Acquired Pneumonia: A Us Perspective On The Guideline Gap, Maricar Malinis, Lilian Abbo, Jose A Vazquez, Luis Ostrosky-Zeichner

Faculty, Staff and Student Publications

Community-acquired pneumonia continues to be one of the most common causes of morbidity and mortality due to infectious disease. The aetiologies, clinical presentations, diagnostic modalities and therapeutic options are changing and outpacing the creation of management guidelines. This educational article summarizes a roundtable activity sponsored by an unrestricted educational grant by Paratek that included US experts discussing these changes and identifying gaps in the current guidelines.

The Spectrum Of Pneumonia Among Intubated Neonates In The Neonatal Intensive Care Unit, Dayle J. Bondarev, Rita M. Ryan, Devashis Mukherjee

Faculty Scholarship

We review the pathophysiology, epidemiology, diagnosis, treatment, and prevention of ventilator-associated pneumonia (VAP) in neonates. VAP has been studied primarily in adult ICU patients, although there has been more focus on pediatric and neonatal VAP (neo-VAP) in the last decade. The definition as well as diagnosis of VAP in neonates remains a challenge to date. The neonatal intensivist needs to be familiar with the current diagnostic tools and prevention strategies available to treat and reduce VAP to reduce neonatal morbidity and the emergence of antibiotic resistance. This review also highlights preventive strategies and old and emerging treatments available.

Antimicrobial Efficacy Of Intercanal Medicaments Against A Mature Multi-Species Biofilm Model: An Ex-Vivo Study, Shehabeldin Mohamed Saber, Nada Zakaria, Mohamed Nagy, Soha Elhady

International Arab Journal of Dentistry

Introduction: The aim of this study was to compare the efficacy of different antimicrobial agents, including Ciprofloxacin, Doxycycline, Clindamycin, Metronidazole, Amoxicillin and Clavulanate, Triple antibiotic paste (TAP) and Calcium hydroxide (CH), as intra-canal medications for regenerative endodontics against an aged, multispecies ex-vivo biofilm model.

Methods: A total of one hundred fifty single-rooted human teeth were used in this study. Fifteen teeth were used to monitor the formation and maturation of a multispecies biofilm model consisting of Enterococcus faecalis, Staphylococcus epidermidis and Candida albicans. After 21 days of incubation, the other one-hundred and thirty-five teeth were divided into 9 …

The Role Of Ppars During Coxiella Burnetii Infection, Kaitlin C. O'Boyle, Maria Biancaniello, Minal Mulye

Research Day

Introduction

The obligate intracellular bacterium, Coxiella burnetii is transmitted to humans via inhalation of contaminated aerosols and subsequently causes Q fever. Coxiella persists in modified phagolysosomes termed Coxiella-containing vacuoles (CCV) within the alveolar macrophages it infects. Acutely, Q fever presents as a flu-like illness; however, chronic infection is often characterized by non-curable endocarditis. Q fever endocarditis can develop years after the initial infection, indicating the bacterium's ability to survive long-term. While the specific host cell pathways Coxiella targets to achieve this long-term survival remain unknown, our lab has demonstrated that Coxiella actively manipulates host lipid storage organelles known as …

Rapid Increase Of Female But Not Male Obesity: Analysis Of The 2023 Vanuatu Health Transition Project Survey On Aneityum, Matthew Christian, Olivia Lasalle, Zhiqiao Huang, Hannah Chen, Ricky Chen, J. Koji Lum

Binghamton University Undergraduate Journal

Globally, obesity rates are continuing to increase and countries in the midst of modernization are most vulnerable. Developing nations are undergoing a health transition alongside rapid economic modernization. The nation of Vanuatu, like other Pacific island countries, is experiencing such a transition marked by decreased cases of infectious disease and increased incidence of chronic and non-communicable diseases. Aneityum is a small and sparsely populated island in Vanuatu and is behind more developed islands in its transition. This present study is the latest in a multi-year project examining health in Vanuatu as it undergoes a health transition with an increased prevalence …

A Survey Of Pet Caretakers On The Use And Perceptions Regarding Heartworm Prophylaxis For Prevention Of Canine Heartworm Disease, Stacie Williams, Charles T. Faulkner

Faculty Other Scholarly Content

Canine heartworm disease (CHWD) is caused by infection with the nematode parasite Dirofilaria immitis transmitted through the bite of a mosquito carrying the infective stage larva. The disease is insidious in its onset and almost 100% preventable with the use of highly effective pharmaceutical compounds that target the migrating larval stage acquired from the mosquito. However, use of canine heartworm prophylaxis among pet dog caretakers is not universally accepted and sometimes viewed with skepticism. Previous research conducted in the Cumberland Gap Region (CGR) indicated that 41.8% of dog owning individuals do not use prophylactic products. In this study, we surveyed …

Seventy-Five Years Of Global Health Lawmaking Under The World Health Organization: Evolving Foundations Of Global Health Law Through Global Health Governance, Benjamin Mason Meier, Alexandra Finch

O'Neill Institute Papers

The World Health Organization (WHO) has been shaped by global health law throughout its history. Drawing from the post-war establishment of global governance under the United Nations (UN), the modern foundations of global health law were laid by the WHO Constitution, which provided WHO with a range of normative authorities to realize its mandate as the UN’s directing and coordinating authority in global health. Yet WHO has faced political challenges in exercising these normative authorities to advance global health law, revealing the limitations of law as a foundation of global health governance. This article chronicles the 75-year evolution of global …

Increasing Human Papillomavirus Vaccine Uptake In Primary Care Using The 4 Pillars Program: A Quality Improvement Project, Hannah Lyons

The Eleanor Mann School of Nursing DNP Capstone Projects

Aim: To explore the effectiveness of the 4 Pillars Program on increasing human papillomavirus vaccination use in patients ages 9-18 years.

Design: A retrospective quasi-experimental research design comparing pre- and post-implementation human papillomavirus vaccination rates.

Keywords: human papillomavirus, vaccination, pillars, program, communication, tool, quasi-experimental, retrospective

Methods: A retrospective chart review identified the rate of encounters per provider where the human papillomavirus vaccine was administered to patients ages 9-18 years. Interventions including increasing access to the vaccine, standardizing provider recommendation of the vaccine, enhancing utilization of the electronic health record, and introducing a vaccine champion, known as …

The Saudi Government's Response To Covid-19: A Social Media Analysis, Raghad Sonbul

Dissertations

In 2020, COVID-19 invaded the world and caused massive losses, materially, morally, and psychologically. Countries worldwide tried to mitigate the damages by taking strict precautionary measures. The response of governments to this pandemic varied. This study explored the Saudi government’s response to the pandemic by examining its official Twitter accounts. Saudi Arabia holds an important position, economically, politically, and religiously. Thus, its response to COVID-19 affects its international image and reputation, as well as the tremendous number of people who visit the country annually during the Umrah and Hajj seasons. A qualitative content analysis was conducted, and 1,007 tweets posted …

Synthesis Of Poly-N-Methylated Peptides Against Malaria, Kaitlyn Watson

Theses & Dissertations

Malaria, a life-threatening global health concern, is primarily targeted by mainstream treatments such as artemisinin-based combination therapies, focusing on the blood stage of the disease. Primaquine, one of the few drugs active against the liver stage, faces challenges with reports of resistance in Plasmodium vivax strains and relapsing infections. With the scarcity of liver-stage-targeting drugs and increasing cases of drug-resistant malaria, the World Health Organization emphasizes the urgent need for novel therapeutic agents. Marine organisms are a rich source of new bioactive compounds, and extracts from the Antarctic Sea sponge Inflatella coelosphaeroides revealed new N-methylated peptides exhibiting promising antimalarial activity, …

Following National Guidelines And Treatment To Eradicate Streptococcus Pharyngitis In Pediatrics, Rosa I. Montenegro

Cohort XII

Introduction: Sore throat (acute pharyngitis) is considered a prevalent disease worldwide among children and adults that requires healthcare. It is important to know that the etiology of sore throat in 70%-95% of cases is viral. Streptococcus pyogenes (group A streptococcus) is detected in approximately 15%-30% of all cases with sore throat, 5%-15% in adults, while 20%-30% in children. For the diagnosis of GAS infection, a throat swab is the gold standard procedure. Most guidelines are based on the seriousness of GAS infection to support the decision on the use of antibiotic treatment. All guidelines on sore throat give recommendations on …

Isolation Of Aged Mouse Primary Microglia As A Model System For Alzheimer’S Disease Research, Michael Landis

Biology Honors Papers

Microglia and their role as the immune cells of the central nervous system are an emerging area of interest within Alzheimer’s research, particularly as they have shown in a benevolent and malevolent cellular context. Models of Alzheimer’s disease are very light in studying microglia, so in this study a model of microglia isolated from aged mice is established in order to study the phagocytic activity and protein expression of microglia in response to Amyloid Beta. The cells were isolated from aged mice and cultured before being used to confirm cellular identity, as well as to measure phagocytic activity. This study …

Respiratory Syncytial Virus (Rsv) Transmission In Household Settings, Montserrat Santos, Anjana Sasidharan, Trina Regis, Kelly Fatheree, Manjusha Rani, Dithi Banerjee, Rangaraj Selvarangan

Research at Children's Mercy Month 2024

Background and aim: Children play a significant role in the transmission of respiratory viruses within households and communities. This gives significance to pediatric studies in how they can provide insight about transmission within households. There are currently a limited number of RSV transmission studies in family clusters conducted in the USA. We aimed to monitor the spread of RSV in prospectively enrolled families and determine viral shedding from multiple specimens in index child (IC) and their household contacts (HHC).

Method: Children (>1 month and <18y) who tested positive for RSV at Children’s Mercy Hospital, and their HHCs were consented to provide demographic and clinical data. Multiple specimens such as nasal swab (NS), saliva (SA), stool (ST), and blood (B) from IC and HCC were collected over 3 weeks. Nucleic extractions were performed, and RSV RT-PCR was done on the samples from the different time points for viral detection.

Results: Overall, 3 families with 12 subjects (3 IC and 9 HHC) were enrolled between …

Illuminated Magazine, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

From the Graduate School; Connecting Cultures and Overcoming Adversity through Art: One Artist’s Perspective, [Akintayo Akintobe, Studio Art, MFA]; Where Are They Now? [Featuring Emily Lu]; Bridging the Gap in Patient Self-Care: The Lived Experiences of Young Adults with Type 2 Diabetes, [Holly Berry-Price, Nursing, PhD]; Where Are They Now? [Featuring Oluwafisayo Ogundoro]; Examining the Causes of COVID-19 Vaccine Hesitancy Among People Living with HIV, [Charles Olomofe, Public Health, DrPH]; Where Are They Now? [Featuring Julianna Cole]; Uncovering East Tennessee’s History through a Material Lens, [Slade Nakoff, History, MA]; Where Are They Going? [Featuring Tess Ann Simpson]; Filling the Gaps: …

Random-Effects Substitution Models For Phylogenetics Via Scalable Gradient Approximations, A. F. Magee, A. J. Holbrook, J. E. Pekar, Itzue W. Caviedes-Solis, F. A. Matsen Iv, G. Baele, J. O. Wertheim, X. Ji, P. Lemey, M. A. Suchard

Biology Faculty Works

Phylogenetic and discrete-trait evolutionary inference depend heavily on an appropriate characterization of the underlying character substitution process. In this paper, we present random-effects substitution models that extend common continuous-time Markov chain models into a richer class of processes capable of capturing a wider variety of substitution dynamics. As these random-effects substitution models often require many more parameters than their usual counterparts, inference can be both statistically and computationally challenging. Thus, we also propose an efficient approach to compute an approximation to the gradient of the data likelihood with respect to all unknown substitution model parameters. We demonstrate that this approximate …

Impact Of Pollution On Marginalized Communities: Case Study Of Omaha, Nebraska, Miqaela Davis

Department of Environmental Studies: Undergraduate Student Theses

Environmental justice has been a struggle within our country for years. The goal of Environmental justice is for the fair treatment and equal voice for every single individual regardless of race, income, gender, etc. There has been environmental injustice and racism in many cities, but this study focuses on Omaha, Nebraska. Key questions include: What are some specific pollutants that are prevalent in areas with differing racial majorities in Omaha? What are some of the health patterns in these areas and does it relate to environmental racism? How has Omaha reinforced environmental racism through city planning? Using the Climate and …

From Cells To Clinics- The Role Of College Biology Education In Shaping Future Physician Assistants, Monica Manley

Honors Theses

This thesis provides a personal reflection on translating concepts and techniques learned in multiple biology courses (i.e. microbiology, neuroscience, comparative physiology, and genetics) in to clinical practice as an intern in the emergency room of a hospital. Each selected concept contains a description followed by an example of how this knowledge relates to a specified duty of a physician assistant with in an emergency medical setting.

Artificial Intelligence Applications For Optimizing Population And Clinical Drug Decision-Making Processes, Khulud Bukhari

Pharmaceutical Sciences (PhD) Dissertations

Introduction: In our study, we evaluated the application of ChatGPT4, an artificial intelligence chatbot, in the pharmacy field, specifically the capability of ChatGPT4 to extract and analyze FDA drug information, conduct a cost-effectiveness analysis of two antibiotics, and identify and classify adverse drugs events (ADE). We compare the results of ChatGPT4 with those from manual searches and specialized software programs. Methods: The first study used ChatGPT4 to extract and assess the quality of regulatory information for antibiotics indicated for complicated urinary tract infections (cUTI) approved by the FDA in 2014-2023. The second study involved comparing the cost-effectiveness analysis of cefiderocol …

Tongue-Tie: Impact On Oropharyngeal Function During Swallow., Kolbie A. Vincent

Electronic Theses and Dissertations

Swallowing is an intricate process involving over 50 muscle pairs and numerous nerves, with dysphagia resulting from deficits in various stages (Hennessy & Goldenberg, 2016). Lingual restriction may adversely impact swallowing function, affecting bolus preparation, size, and overall efficiency. Tongue-tie can pose challenges to speech, chewing, and swallowing (Becker & Mendez, 2022; Chaubal et al, 2011; García-Pola, M. J., et al., 2002). This pilot study seeks to determine how tongue-tie affects swallowing function in an adult male, and whether surgical revision of a submucosal lingual tether leads to measurable changes in oropharyngeal swallow function. Results showed inconsistent changes in diameter …

Exploring Influencing Factors On The Adoption Of Non-Pharmaceutical Interventions During Pandemics: Covid-19 As An Example., Ahmed Abdulmohsen I Alobaydullah

Electronic Theses and Dissertations

Background: Pandemics are associated with loss of life, hospitalizations, and disruption to people’s social and economic lives. As the 2019 pandemic illustrates, COVID-19 can be prevented by pharmaceutical and non-pharmaceutical interventions (NPIs). Recommended measures such as wearing a mask, washing hands, social distancing, and self-quarantine have been proven to curb the spread of the coronavirus. Identifying the factors associated with adherence to NPIs is the first step in understanding which levers of change to pull when designing health promotion interventions such as health communication campaigns. This dissertation explores these factors and proposes a health communication framework during pandemics. Research Questions: …

Porphyromonas Gingivalis Inactivates Anti-Viral Immunity At The Oral And Respiratory Epithelium., Carlos J. Rodriguez Hernandez

Electronic Theses and Dissertations

The host microbiome plays an important role in fine-tuning host immune responses in a manner that ultimately impacts outcomes in viral infection. Symbiotic relationships between commensal bacteria and host epithelial and immune cells prime interferon (IFN) signaling, modulating the nature and intensity of the immune response to viral infections at mucosal barrier surfaces. In this doctoral thesis, I explore how dysbiotic shifts in the oral microbial communities modulate antiviral responses at the oral and oro-respiratory mucosal barriers. I identified that in response to a viral challenge, gingival epithelial cells (GECs) preferentially induced type III IFNs (IFN-λ), a newly described family …

Investigation Of Avaren-Fc's Therapeutic Potential Against Ovarian Cancer., Katarina Lee Mayer

Electronic Theses and Dissertations

This thesis describes the investigation of Avaren-Fc (AvFc), a novel lectin-based therapeutic fusion protein consisting of the recombinant Avaren lectin and the Fc region of human IgG1, against ovarian cancer. AvFc possesses selectivity toward tumor associated N-linked high-mannose-type glycans. The present study demonstrates AvFc’s in vitro activity against OVCA cell lines via antibody-dependent cell-mediated cytotoxicity and its ability to extend the survival of mice challenged with murine ID8 OVCA cells after repeated systemic administration. Furthermore, AvFc treatment in this model was found to increase the presence of peritoneal leukocytes, suggesting a shift toward an improved antitumor immune response. Another key …

Global To Glocal: A Confluence Of Data Science And Earth Observations In The Advancement Of The Sdgs, Rejoice Thomas

Computational and Data Sciences (PhD) Dissertations

The United Nations' (UN) Sustainable Development Goals (SDGs), part of Agenda 2030, comprise 17 interconnected goals and 169 actionable targets, providing an effective framework for addressing diverse issues ranging from individual challenges such as poverty, hunger, and health to broader corporate and global challenges like climate change and equality. Among these interconnected SDGs, this dissertation focuses on the role of climate and infrastructure in global and local sustainability. To this end, earth observations have been conducted utilizing data science techniques to advance these SDGs. For this dissertation, the author has conducted earth studies serving the following SDGs:

1. SDG 3 (Good …

Nsu Business Graduate Student Catalog 2024-2025, Nova Southeastern University

Huizenga Postgraduate Course Catalogs

No abstract provided.

Best Practices In Project Portfolio Management, Meda Snyder

Student Projects for Graduate Degrees

The Alaska Native Tribal Health Consortium (hereafter ANTHC) is a non-profit health organization owned and managed by Alaska Native tribal governments and their regional health organizations. ANTHC had $114 million in grant funded projects and 150 active DEHE projects for 2021 (ANTHC Annual Report, 2021). As of fiscal year 2022 DEHE will have approximately $180 million from the federal infrastructure funding that will more than double the current amount of design and construction projects for the next five to ten years (Murkowski Infrastructure Bill Report, n.d.). Coupled with labor and material shortages across all industrial sectors, ANTHC has a need …

Impact Of Housing First Supportive Housing Provision On Healthcare Accessibility And Health Status Of Individuals Who Previously Experienced Homelessness, Aubrey Haughn, Tiffany Loh, Jason Adam Wasserman

Posters

• The 2020 AHAR report to Congress revealed about 580,000 people experience homelessness on a single night.
• Approximately 3 out of every 200 people have experienced homelessness.
• Individuals experiencing homelessness face higher risks of infectious diseases, injuries, mental health issues, substance abuse, and suicide.
• Individuals experiencing homelessness are 6-10 times more likely to have unmet healthcare needs compared to the general population.
• In contrast to a treatment-first approach, the housing first (HF) approach of supportive housing focuses on provision of immediate stable housing for individuals experiencing homelessness without preconditions regarding substance use.
• Avalon House Hickory Way are newly implemented HF apartments …

Global Incidence, Prevalence, Years Lived With Disability (Ylds), Disability-Adjusted Life-Years (Dalys), And Healthy Life Expectancy (Hale) For 371 Diseases And Injuries In 204 Countries And Territories And 811 Subnational Locations, 1990–2021: A Systematic Analysis For The Global Burden Of Disease Study 2021, Gbd 2021 Diseases And Injuries Collaborators, Veincent Christian F. Pepito

Ateneo School of Medicine and Public Health Publications

Background

Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors …

Development Of An Online Teaching Platform To Improve Access To Postgraduate Pathology Training In Sub-Saharan Africa, Richard Byers, Anita Byers, Chibamba Mumba, Angela Mutuku, Jennifer Singer-Rupp, Michael Wilson, Kenneth Fleming, Shahin Sayed

Pathology, East Africa

Background: Resource barriers to the provision of accessible training in cancer diagnosis in lower- and middle-income countries (LMICs) limit the potential of African health systems. Long-term provision via teaching visits from senior pathologists and trainee foreign placements is unsustainable due to the prohibitive costs of travel and subsistence. Emerging eLearning methods would allow pathologists to be trained by experts in a cheaper, more efficient, and more scalable way.

Purpose: This study aimed to develop an online teaching platform, starting with hematopathology, for trainee pathologists in sub-Saharan Africa, initially in Nairobi, Kenya, and Lusaka, Zambia.

Methods: Course materials …

Climate Change And Human Health: A Synthesis Of Scientific Research And State Obligations Under International Law, Jessica A. Wentz

Sabin Center for Climate Change Law

This report synthesizes the latest scientific research on the human health effects of climate change and discusses the legal implications of this research, specifically with regards to State obligations under international law. In doing so, the report seeks to provide insights on issues to be analyzed by the International Court of Justice (ICJ) in its upcoming advisory opinion on the legal obligations of States with respect to climate change. It also seeks to enhance the capacity of judges, advocates, and governments to understand these issues in the context of current and future proceedings involving international law obligations related to climate …