Digital Commons Network^™

Greening The Edge: Investigating Riparian Buffer Restorations In A Pastoral Setting And Their Effects On Soil Carbon And Microbial Community Composition., Seth Mccullough

Masters Theses, 2020-current

Riparian buffer restoration represents a critical strategy for enhancing ecosystem health and resilience in agricultural landscapes. This study investigates the effects of riparian buffer restoration on soil properties, microbial communities, and carbon dynamics in Rockingham County, VA. Through a comprehensive field study, we assessed the physicochemical properties of soil, microbial biomass, community composition, and soil carbon storage in restored and unrestored riparian buffers. Our findings reveal significant improvements in soil physical properties in restored buffers, including increased soil moisture (p < 0.05) and decreased bulk density (p < 0.01), indicating enhanced soil structure and water retention capacity. While no significant differences were detected in soil pH or cation exchange capacity, restored buffers exhibited higher soil carbon stocks (p < 0.05) and carbon-to-nitrogen ratios, suggesting potential differences in nutrient cycling processes and organic matter decomposition rates. Moreover, restored buffers showed increased microbial biomass (p < 0.01), potentially driven by improved habitat conditions and shifts towards a fungal-dominated microbial community.

Although no significant differences were found in overall microbial community composition between restored and unrestored sites, specific shifts in bacterial …

Implementing A Clinical Practice Guideline To Reduce Antibiotic Use In Asymptomatic Bacteriuria, Connie Sue Clum

Dissertations

Antibiotic use in asymptomatic bacteriuria (ASB) may not be necessary. At the project site, there was no systematic process to manage ordering antibiotics and urine cultures without first diagnosing a urinary tract infection, so an evidence-based solution was sought. The purpose of this quality improvement project was to determine if implementing an antimicrobial stewardship program utilizing the Infectious Disease Society of America (IDSA) Clinical Practice Guidelines for the Management of Asymptomatic Bacteriuria would impact urine cultures ordering and antibiotic use among adult patients admitted to the general medical service. The project was piloted over 12 weeks in an urban hospital …

Relationship Satisfaction For Significant Partners Of The Incarcerated: An Interpretative Phenomenological Analysis, Carrie Elizabeth Lund

Electronic Theses and Dissertations Archive

The United States incarcerates more individuals than any other country in the world (The Sentencing Project, 2023). Because of this, it is imperative that counseling professionals understand the lived experiences of those impacted by incarceration. Though research exists focusing on the effects of incarceration on children and families, there is still only a small body of research dedicated to understanding how incarceration impacts significant partners of the incarcerated. This study examined the lived experiences of eight significant partners of the incarcerated (SPIs) to better understand the ways in which incarceration impacted their romantic relationship satisfaction. Through the use of Interpretative …

Methods For The Analysis Of Diffusible Signaling Factors For The Determination Of Elution Activity, Structural Stability And Biological Activity, Brian Hoffman

Electronic Theses and Dissertations Archive

Biofilms pose a threat to public health. The National Institutes of Health estimate that biofilms are linked to 65-80% of hospital-related infections. Biofilms are a complex network of bacterial cells contained within an extracellular matrix and are 10-1000 times more resistant to common antibiotic treatments. Bacteria within a biofilm utilize a form of intercellular communication known as quorum sensing to regulate many cellular functions including the secretion of the extracellular matrix and dispersal of planktonic cells. Compounds known as diffusible signaling factors (DSF) regulate the formation/degradation of the extracellular matrix. One family of DSF consist of medium chain fatty acid …

Distinct Autoantibody Profiles Across Checkpoint Inhibitor Types And Toxicities, Hong Mu-Mosley, Mitchell S Von Itzstein, Farjana Fattah, Jialiang Liu, Chengsong Zhu, Yang Xie, Edward K Wakeland, Jason Y Park, Brad S Kahl, Catherine S Diefenbach, David E Gerber

2020-Current year OA Pubs

Immune checkpoint inhibitors (ICI) are increasingly used in combination. To understand the effects of different ICI categories, we characterized changes in circulating autoantibodies in patients enrolled in the E4412 trial (NCT01896999) of brentuximab vedotin (BV) plus ipilimumab, BV plus nivolumab, or BV plus ipilimumab-nivolumab for Hodgkin Lymphoma. Cycle 2 Day 1 (C2D1) autoantibody levels were compared to pre-treatment baseline. Across 112 autoantibodies tested, we generally observed increases in ipilimumab-containing regimens, with decreases noted in the nivolumab arm. Among 15 autoantibodies with significant changes at C2D1, all nivolumab cases exhibited decreases, with more than 90% of ipilimumab-exposed cases showing increases. Autoantibody …

Frankincense (Boswellia Serrata) Extract Effects On Growth And Biofilm Formation Of Porphyromonas Gingivalis, And Its Intracellular Infection In Hujman Gingival Epithelial Cells, Nicholas Zusman

Excellence Day

Traditional antibiotics have been commonly used to treat several infectious diseases for decades, however, misuse and over-prescription have been escalating antibiotic resistance episodes. Boswellia serrata extract, derived from Boswellia trees prevalent in the Middle East, Africa, and Asia, offers multifaceted therapeutic benefits, including anti-cancer, anti-inflammatory, and anti-microbial effects. Periodontitis affects 20-50% of the global population, targeting the gingival tissues, supporting structures around teeth, and the alveolar bone. Porphyromonas gingivalis and Fusobacterium nucleatum are two prominent bacterial culprits in this pathogenesis. This study investigated the potential antimicrobial effects of B. serrata extracts against P. gingivalis and F. nucleatum. Using minimum inhibitory …

Assessment Of Bacterial Diversity In South Georgia Water Sources Using Bacterial Isolation And Maldi Tof-Based Identification, Teighlor Livingston, Andrew Metry, Sammy Elmor, Steven Li, Hunter Medley, Alleluia Nishimwe, Nishi Patel, Gary Sellers, Daniel Torres, Girija Regmi, Allen Kalantari, Hemant K. Naikare, Nikita Mirajkar

Research Day

Background

Water bodies support diverse life but are vulnerable to microbial contamination, endangering human, animal, and plant health, especially in rural areas with limited clean water access. Regular water sample surveillance is vital to protect public health and prevent adverse effects. In addition to monitoring current filtration processes, this study surveys rural South Georgia's water sources to establish a baseline microbial profile for future comparative analysis.

Methods

Biweekly water sampling occurred from November 2023 to January 2024 in rural South Georgia, covering diverse sites such as lakes, ponds, filtered water fountains, and a city water treatment facility. Samples were collected …

Considering The Historical And Systemic Context, To What Extent Are Cuban Women’S Healthcare And Reproductive Rights Affected By The Privacy And Social Influence Of Cuba Today?, Autumn Cowell

Student Research Symposium

This paper will examine how historical and systemic values continue to frame social influences thus impacting Cuban women’s healthcare and reproductive rights. If the impact of history and systems still affects social influences then Women’s Healthcare and Reproductive Rights may be compromised. This investigation will highlight the potential benefits and risks of historical and systemic values that have affected challenges or changes within Cuban culture. And how these social influences are found within the areas of prevention, intervention, and treatment. This paper hopes to outline how the Cuban government and society are sustaining the protection of Cuban women’s access to …

The Impact Of Turnover And Turnover Intentions On Nigeria's Public Health Administration, Albert Abani Uduma

Walden Dissertations and Doctoral Studies

High turnover creates a vicious cycle that affects employees with further shortages and turnover. This study explored the lived experiences and perceptions of a government employer and employees about turnover, turnover intentions, and the government’s leadership effectiveness using Heidegger’s phenomenological research methods. The theoretical frameworks that grounded the study were Herzberg’s motivation-hygiene theory, public service motivation theory, and corporate social responsibility theory. The study questions focused on stakeholders’ perceptions and lived experiences of the government’s leadership effectiveness in addressing the impacts of high turnover, as well as the employees’ consequent reactions to the government’s leadership approach. Participant data were collected …

Pandemic Pandemonium: The Interconnectedness Of Environmental And Public Health Through The Lens Of Covid-19, Hanna Giedraitis

Student Theses 2015-Present

In 2020, the world was launched into a global pandemic it was completely unprepared to fight. This pandemic began in the midst of tragic environmental disasters, including the largest wildfire recorded in California history. Once the global lockdown began, many long-standing environmental problems began to remedy themselves due to the sudden halt of human interaction. However, there were major environmental setbacks in the healthcare industry as increased medical waste and single-use items became a necessity. This thesis addresses how the pandemic impacted the environment through a lens of sustainability and public health, and how healthcare industries can be more prepared …

Antimicrobial Mechanisms Of Human Lipocalin-2, Lindsey Steinberg

Arts & Sciences Graduate Student Theses and Dissertations

Lipocalin-2 (Lcn2, also known as siderocalin or neutrophil gelatinase-associated lipocalin) is an innate immune protein released by neutrophils and epithelial cells at sites of infection. It is understood to limit bacterial growth by restricting access to iron, an essential nutrient, but it does not avidly bind iron in isolation. At least two iron restricting Lcn2 mechanisms are described in the literature. In the prototypical mechanism, Lcn2 binds and prevents uptake of enterobactin, a high affinity iron chelator secreted by E. coli and closely related Enterobacterales. Sequestration of this bacterial siderophore prevents nutritional iron delivery to these pathogens. However, the narrow …

Bird Flu Spreading To Farmed Mammals In The Us, Andrew N. Rowan, Hope Ferdowsian M.D., M.P.H.

WellBeing News

The more mammalian species infected by bird flu, the greater the threat of a new pandemic.

Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin

Senior Honors Papers / Undergraduate Theses

Human T-cell leukemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes multiple disorders, including adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 retroviral integrase binds to the regulatory B’56γ subunit of the host cell Protein Phosphatase 2A (PP2A). Integrase contains a highly conserved LxxIxE motif that is essential for binding, which increases integration efficiency and facilitates HTLV-1 hijack of host cell machinery. We aim to understand how mutations introduced in the highly conserved binding site can affect viral particle production and infectivity. We transfected 729B human lymphoblastoid cells and 293T cells with mutant and wildtype virus. Mutations L213A, …

Immunopathogenesis Of Post-Infectious Hydrocephalus, Sascha Powers Bernier

Honors Scholar Theses

Hydrocephalus is characterized by the abnormal accumulation of cerebrospinal fluid (CSF) within the brain ventricles. In post-infectious hydrocephalus (PIH) cases, the condition presents challenges in understanding the immune response. PIH is a complex condition, often persisting after the initial infection is treated and thus requiring a deeper understanding of the immune mechanisms involved in its development. This thesis will explore the immunopathogenesis of PIH, elucidating the relationship between the immune response and neurological complications that would succeed infection. The immune response of PIH includes a series of events, beginning with the activation of immune cells and finishing with the release …

Effect Of An Hpv Vaccination Multi-Level, Multi-Component Program On Hpv Vaccination Initiation And Completion In A Pediatric Clinic Network, Lara S Savas, Ross Shegog, Erica L Frost, C Mary Healy, Dale S Mantey, Sharon P Coan, L Aubree Shay, Travis A Teague, Juan J Ferreris, Sharice M Preston, Sally W Vernon

Faculty, Staff and Student Publications

Despite clear evidence of the public health benefits of the human papillomavirus (HPV) vaccine in preventing HPV-related cancers and genital warts, underutilization of HPV vaccination in the United States persists. Interventions targeting multi-level determinants of vaccination behavior are crucial for improving HPV vaccination rates. The study's purpose was to implement and evaluate the adapted Adolescent Vaccination Program (AVP), a clinic-based, multi-level, multi-component intervention aimed at increasing HPV vaccine initiation and completion rates in a five-clinic pediatric network in Bexar County, Texas. The adaptation process was guided by established frameworks and involved formative work with clinic stakeholders. The study utilized a …

Correction: Horne Et Al White Matter Correlates Of Domain-Specific Working Memory, Autumn Horne, Junhua Ding, Tatiana T Schnur, Randi C Martin

Faculty, Staff and Student Publications

In the original publication [...].

Optimization Of The Antifungal Properties Of The Bacterial Peptide Entv By Variant Analysis, Shantanu Guha, Shane A Cristy, Giuseppe Buda De Cesare, Melissa R Cruz, Michael C Lorenz, Danielle A Garsin

Faculty, Staff and Student Publications

Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by Enterococcus faecalis, EntV, that restricts Candida albicans to a benign form rather than having direct fungicidal activity. Moreover, we showed that one 12-amino acid (aa) alpha helix of this peptide retained full activity, with partial activity down to the 10aa alpha helix. Using these peptides as a starting point, the current investigation sought to identify the critical features necessary for antifungal activity and to screen for new variants …

Assessment Of The Characteristics Of Covid-19 Infection Among Healthcare Personnel Working In Long-Term Care Facilities, Armaghan-E-Rehman Mansoor, Caroline A O'Neil, David Mcdonald, Victoria J Fraser, Hilary M Babcock, Jennie H Kwon

2020-Current year OA Pubs

Between May and June 2021, healthcare personnel at two long-term care facilities underwent SARS-CoV-2 anti-nucleocapsid immunoglobulin G testing and completed a survey on COVID-19 exposures and symptoms. Antibody positivity rate was 8.9%. Similar rates of COVID-19 exposure occurred in non-occupational and occupational settings, with high self-reported adherence to workplace infection prevention practices.

The Unusual Suspect: Citrobacter Infection As A Rare Cause Of Renal Abscess, Nismat Javed, Nishant Allena, Sai Allu, Paul Kelly

Journal of Community Hospital Internal Medicine Perspectives

Citrobacter infections have emerged as now a common nosocomial pathogen. Most of the infections manifest in patients with underlying medical conditions. The features of infection can range from infections in the lower urinary tract, respiratory tract, gastrointestinal disease, or bacteremia, however renal abscesses remain uncommon. Here we present the case of a 48-year-old female with medical history of diabetes that presented with a right renal abscess secondary to Citrobacter koseri infection managed with drainage and antimicrobial treatment.

A Changed Man: A Rare Case Of Behcet's Disease Autoimmune Encephalitis, Jonathan London, Kevin Rulka, Gayatri Bobba, Justeena Joseph, Zubin Tharayil, Mark Gudesblatt

Journal of Community Hospital Internal Medicine Perspectives

Behcet’s disease (BD) is characterized by recurrent oral ulcers with concomitant systemic multi-organ involvement, which may include neurological disease, ocular disease, vascular disease, genital ulcers, skin lesions, and arthritis. The clinical symptoms arise from vasculitis that involves small, medium, and large blood vessels. We present the case of a young male who presented with atypical Behcet’s autoimmune encephalitis with recurrent oral ulcers, neurological manifestations, HLAB51 positivity, abnormal EEG findings, and improvement following multiple plasma exchange treatments.

Echocardiographic Features Of An Evolving Periaortic Valvular Abscess In A Patient With Staphylococcus Epidermidis Prosthetic Valve Endocarditis, Sherif Elkattawy, Jesus Romero, Ana L. Romero, Erkanda Bilali, Davin Turku, Fareeha Abid, Razan Shamoon, Fayez Shamoon

Journal of Community Hospital Internal Medicine Perspectives

Prosthetic valve endocarditis is a serious complication following valve replacement surgery, with the development of aortic root abscess being a catastrophic manifestation. We present a case of a 71-year-old female with a bioprosthetic aortic valve who presented with shortness of breath. Echocardiographic findings revealed vegetation on the prosthetic aortic valve with a periaortic, annular abscess. Given the patient’s comorbidities and high surgical risk, conservative management with antibiotics was chosen. The patient responded well to antibiotic therapy and was discharged with long-term antibiotic treatment. Prosthetic valve endocarditis, particularly with periaortic abscess formation, is associated with significant morbidity and mortality. Early diagnosis …

Hesitancy Towards Covid-19 Vaccine Among Students Of Medical And Allied Health Sciences In Pakistan: A Cross Sectional Study, Maham Zahid, Youhib U. Rehman, Asif Rehman, Khalid Rehman

Journal of Community Hospital Internal Medicine Perspectives

Objective: To measure COVID-19 vaccine hesitancy and its associated factors among medical and allied health sciences students of Khyber Pakhtunkhwa Methodology: This cross-sectional survey was conducted online using Google survey platform in March 2021. Study population comprised of medical and allied health sciences students studying in medical/allied health sciences academic institutes in Khyber Pakhtunkhwa. The web-based online link was provided to around 800 students to fill in the questionnaire via email, WhatsApp and/or social media network. Response rate was around 50%. The main outcome variable was vaccine hesitancy. Factors associated with vaccine hesitancy were explored by bivariate and multivariate regression …

A Review Of Current Mrna-Based Cancer Vaccinations With Special Consideration For Future Breast Cancer Prevention Strategies, Alexandra She, Alexa Cornwell, Francis Jenney

Research Day

INTRODUCTION: According to the World Cancer Research Fund International (WCRFI), breast cancer (12.5%) has now topped lung cancer (12.2%) as the most prevalent form of cancer in the world (WCRFI, 2022). While therapeutic advances continue to be made, the current treatment of cancer is widely associated with severe side effects from classic therapies such as radiation and chemotherapy. Over the last two decades, studies have examined breast cancer vaccines in pre-clinical and clinical settings. Here, we present an in-depth review of current mRNA-based cancer vaccine literature to assess the prevalence of this technology in this field of medicine. This includes …

Diagnostic Ambiguity Of Distal Dvt (Ddvt) Misdiagnosed As Nonpurulent Lower Extremity Cellulitis (Nlec): A Case Study, Jessica M. Ruiz-Myara, Hunter Alberto Vásquez, Joy Zarandy

Research Day

Introduction

Given the lack of a definitive diagnostic test for cellulitis, about 39% of cases are misdiagnosed. The repercussions of misdiagnosing nonpurulent lower extremity cellulitis (NLEC) for deep vein thrombosis (DVT) can be grave, considering the potential risk of pulmonary embolism (PE). While distal DVT (dDVT) is associated with <5% of PE formation, about 25% of untreated dDVT can ascend to the proximal leg veins; whereas 50% of proximal DVTs (pDVT) progress to PE development within a 3-month timeframe.

Case Report

A 50-year-old female presents to her PCP with a right medial ankle rash for 2 days. She denies inciting events, fever, chest pain, dyspnea, weeping lesions, or swelling. Past medical history includes obesity and controlled diabetes mellitus. Vitals are normal. Examination reveals a 10 x 6 cm blanchable, erythematous …

Chronic Stress-Induced Neuroinflammation: Relevance Of Rodent Models To Human Disease., Abigail G White, Elias Elias, Andrea Orozco, Shivon A Robinson, Melissa T Manners

College of Science & Mathematics Departmental Research

The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, and molecular responses. In humans, chronic stress manifests as an enduring consistent feeling of pressure and being overwhelmed for an extended duration. This can result in a persistent proinflammatory response in the peripheral and central nervous system (CNS), resulting in cellular, physiological, and behavioral effects. Compounding stressors may increase the risk of chronic-stress-induced inflammation, which can yield serious health consequences, including mental health disorders. This review summarizes the current knowledge surrounding the neuroinflammatory response in rodent models of chronic stress-a …

Rethinking Shelter: Designing A Home For Atlanta's Homeless Families And Youth, Maddi Dutton

Bachelor of Architecture Theses - 5th Year

Homelessness is a devastating experience, and its impacts are suffered by Atlanta’s families and youth who find themselves without stable housing. Family homelessness often results in the separation of families, leading to unaccompanied youth living on the streets or in uncomfortable shelters. Existing shelters do not provide family accommodations. They offer basic services and mostly lack a sense of community and personalized private spaces that are essential for fostering a sense of dignity. As emphasized in House as a Mirror of Self by Clare Cooper Marcus, humans need a ‘home’ not just a dwelling. A physical space becomes a home …

The Relationship Between Ultrarunning Status, Subjective Well-Being, And Life Satisfaction, Raquel Ramirez Hernandez

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic resulted in a rise in mental health challenges across the United States. Consequently, two important well-being measures for Healthy People 2030—subjective well-being and life satisfaction—were negatively impacted. A plethora of evidence exists about the benefits of running for physical and mental health. Yet, there is no available evidence that shows the benefits of ultrarunning, subjective well-being, and life satisfaction. This quantitative cross-sectional study examined the relationship between ultrarunning status, subjective well-being, and life satisfaction among adult runners in the United States. The advanced triangle of epidemiology served as the conceptual framework. A convenience sample included 369 adult …

Researching Covid To Enhance Recovery (Recover) Pediatric Study Protocol: Rationale, Objectives And Design., Rachel S. Gross, Tanayott Thaweethai, Erika B. Rosenzweig, James Chan, Lori B. Chibnik, Mine S. Cicek, Amy J. Elliott, Valerie J. Flaherman, Andrea S. Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L. Jernigan, Elizabeth W. Karlson, Stuart D. Katz, Patricia A. Kinser, Lawrence C. Kleinman, Michelle F. Lamendola-Essel, Joshua D. Milner, Sindhu Mohandas, Praveen C. Mudumbi, Jane W. Newburger, Kyung E. Rhee, Amy L. Salisbury, Jessica N. Snowden, Cheryl R. Stein, Melissa S. Stockwell, Kelan G. Tantisira, Moriah E. Thomason, Dongngan T. Truong, David Warburton, John C. Wood, Shifa Ahmed, Almary Akerlundh, Akram N. Alshawabkeh, Brett R. Anderson, Judy L. Aschner, Andrew M. Atz, Robin L. Aupperle, Fiona C. Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M. Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C. Bind, Amanda L. Bogie, Tamara Bradford, Natalie C. Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Maryanne Chrisant, Duncan B. Clark, Rebecca G. Clifton, Katharine N. Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Audrey Dionne, Kirsten B. Dummer, Matthew D. Elias, Shari Esquenazi-Karonika, Danielle N. Evans, E Vincent S. Faustino, Alexander G. Fiks, Daniel Forsha, John J. Foxe, Naomi P. Friedman, Greta Fry, Sunanda Gaur, Dylan G. Gee, Kevin M. Gray, Stephanie Handler, Ashraf S. Harahsheh, Keren Hasbani, Andrew C. Heath, Camden Hebson, Mary M. Heitzeg, Christina M. Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R. Horowitz, Daniel S. Hsia, Matthew Huentelman, Kathy D. Hummel, Katherine Irby, Joanna Jacobus, Vanessa L. Jacoby, Pei-Ni Jone, David C. Kaelber, Tyler J. Kasmarcak, Matthew J. Kluko, Jessica S. Kosut, Angela R. Laird, Jeremy Landeo-Gutierrez, Sean M. Lang, Christine L. Larson, Peter Paul C. Lim, Krista M. Lisdahl, Brian W. Mccrindle, Russell J. Mcculloh, Kimberly Mchugh, Alan L. Mendelsohn, Torri D. Metz, Julie Miller, Elizabeth C. Mitchell, Lerraughn M. Morgan, Eva M. Müller-Oehring, Erica R. Nahin, Michael C. Neale, Manette Ness-Cochinwala, Sheila M. Nolan, Carlos R. Oliveira, Onyekachukwu Osakwe, Matthew E. Oster, R Mark Payne, Michael A. Portman, Hengameh Raissy, Isabelle G. Randall, Suchitra Rao, Harrison T. Reeder, Johana M. Rosas, Mark W. Russell, Arash A. Sabati, Yamuna Sanil, Alice I. Sato, Michael S. Schechter, Rangaraj Selvarangan, S Kristen Sexson Tejtel, Divya Shakti, Kavita Sharma, Lindsay M. Squeglia, Shubika Srivastava, Michelle D. Stevenson, Jacqueline Szmuszkovicz, Maria M. Talavera-Barber, Ronald J. Teufel, Deepika Thacker, Felicia Trachtenberg, Mmekom M. Udosen, Megan R. Warner, Sara E. Watson, Alan Werzberger, Jordan C. Weyer, Marion J. Wood, H Shonna Yin, William T. Zempsky, Emily Zimmerman, Benard P. Dreyer, Recover-Pediatric Consortium

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.

OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of …

The Trnaval Half: A Strong Endogenous Toll-Like Receptor 7 Ligand With A 5′-Terminal Universal Sequence Signature, Kamlesh Ganesh Pawar, Takuya Kawamura, Yohei Kirino

Computational Medicine Center Faculty Papers

Toll-like receptors (TLRs) are crucial components of the innate immune system. Endosomal TLR7 recognizes single-stranded RNAs, yet its endogenous ssRNA ligands are not fully understood. We previously showed that extracellular (ex-) 5'-half molecules of tRNA^HisGUG (the 5'-tRNA^HisGUG half) in extracellular vesicles (EVs) of human macrophages activate TLR7 when delivered into endosomes of recipient macrophages. Here, we fully explored immunostimulatory ex-5'-tRNA half molecules and identified the 5'-tRNA^ValCAC/AAC half, the most abundant tRNA-derived RNA in macrophage EVs, as another 5'-tRNA half molecule with strong TLR7 activation capacity. Levels of the ex-5'-tRNA^ValCAC/AAC half were highly up-regulated in macrophage EVs …

Improving Design And Physical Boundary In Temporary Post-Disaster Relief Shelters: Analysis Of Existing Literature, Min-Hye Jang

Theses

Natural disasters such as floods, hurricanes, cyclones, storms, earthquakes, wildfires, and landslides displace people. As responses at the community resilience level, the temporary post-relief shelter is critical for the community's rapid recovery. Converting existing public facilities is the fastest way to respond to a crisis. However, the Hurricane Katrina Superdome Shelter alerted society to the prevalence of sexual assault in transitory catastrophe contexts. Not only has sexual abuse occurred, but prior shelters did not equip every user with physical barriers to suit their needs. This study examined academic journals, articles, and books to identify issues with natural disaster shelters created …