Digital Commons Network^™

Best Kept Secret: The Hidden Health Costs Of Corporate Confidentiality, Cynthia M. Ho

American University Law Review

Although patents are well known to negatively impact health when drugs are unaffordable, trade secrets also harm health, and in more ways than patents. Patented drugs harm public health simply by temporarily increasing prices on treatments. Trade secrets, on the other hand, can not only increase treatment costs, but also hide knowledge needed for effective medical treatment. Also, because patents, but not trade secrets, have a limited term, patent health harms clearly terminate while trade secret harms do not. Moreover, the public may not even be fully aware of all trade secret health harms because trade secret information is, by …

A Case Displaying The Importance Of Jak1 And Jak2 Gene Transcription In Antifungal Defense Against Coccidioidomycosis, Jennifer K. Priessnitz, Taylor Colore, Nelson Nicolasora

Department of Medicine Faculty Publications

This case report explores the consequences of ruxolitinib via inhibition janus kinase 1 (JAK1) and JAK2 pathways in the context of fungal defense in a patient diagnosed with pulmonary coccidioidomycosis during ruxolitinib therapy for polycythemia vera. The patient experienced a relapse of pulmonary coccidioidomycosis after antifungal treatment was discontinued while continuing ruxolitinib use. This case illustrates the heightened risk of discontinuing antifungal therapy in endemic regions, emphasizing the critical need for continued monitoring. Furthermore, this case underscores the vital role of the JAK1 and JAK2 signaling cascade, particularly the interferon-gamma (INF-γ)-JAK1 and JAK2-signal transducer and activator of transcription 1 (STAT) …

A Study Of The Effect Of Incentives On Police Recruitment And Retention, Taylor R. Wiggins

Theses and Dissertations

This study examines factors contributing to the staffing crisis in police departments, focusing on officers' perceptions of their organizations. It explores their attitudes toward their departments, motivations for joining law enforcement, and reasons for remaining in their positions. Additionally, the research assesses the impact of various incentives on officer retention.

A total of 140 participants were surveyed, with 113 completing the survey in its entirety, ensuring reliable data analysis. Demographic findings revealed a predominantly male sample (85.8%), with most officers aged between 25 and 44. Analysis of the Minnesota Satisfaction Questionnaire (MSQ) indicated that intrinsic satisfaction (M = 3.85; range …

Incarcerated Youth Returning To Society As Adults: An Examination Of Their Lived Experiences And Challenges, Kimberly R. Lawrance

Theses and Dissertations

When children have been incarcerated, they face collateral consequences that make it nearly impossible to recover from when they return home. Collateral consequences are the adverse effects experienced by incarcerated people and their families often causing restrictions or missed opportunities after interaction with the criminal justice system (Moise, Simonsen, & Kearl, 2023). Collateral consequences can be related to housing, employment, and education, to name a few. These lost opportunities are concerning for youth because most have never held a job or finished high school. Collateral consequences often set them up for failure leading to the revolving doors of jails and …

Constructing Bodies Of Subversion And Resistance: The Carceral Quarantine Of Hiv-Positive Haitian Refugees At Guantanamo Bay Under U.S. Imperialism, Isabelle E. Oringer

Scripps Senior Theses

This thesis investigates the detention of HIV-positive Haitian refugees at Guantánamo Bay in the early 1990s as a case study of medicalized racism and U.S. imperialism. It explores how U.S. public health policy, immigration law, and Cold War-era foreign interventions converged to criminalize and confine Black Haitian bodies, constructing them as threats to national security and public health. By analyzing primary testimonies and media coverage alongside the works of scholars such as Paul Farmer and Naomi Paik, the project reveals how racialized conceptions of disease and subversion informed discriminatory practices that disproportionately targeted Haitian refugees. Furthermore, it examines how the …

Navigating Online Perceptions Of Offshore Wind On Social Media: Facebook Discussions On Recent Whale Strandings, Giselle Hausmann

Open Access Master's Theses

The Biden-Harris administration implemented a goal to achieve 30 GW of offshore wind energy by 2030 (US Department of Interior, 2021). The rapid increase in offshore wind activity on the East Coast, combined with NOAA’s declared unusual mortality event in 2016/2017, has sparked a discussion about offshore wind being a potential cause of whale deaths. This paper aims to analyze the discourse on offshore wind and whales through a content analysis of Facebook comments. Facebook pages from Massachusetts (The New England Aquarium), Rhode Island (Rhode Island DEM), New York (The Atlantic Marine Conservation Society), New Jersey (Marine Mammal Stranding Center), …

Utilizing Graph Theory Algorithms For The Modeling And Analysis Of Covid-19 Infection Dynamics, Ioannis Adamopoulos, Antonios Valamontes, Niki Syrou, Jovanna Adamopoulou, Antonios Bardavouras

Mesopotamian Journal of Artificial Intelligence in Healthcare

The COVID-19 outbreak has shown how urgently good models are needed to understand and project the dissemination of infectious diseases. Graph theory's excellent basis for presenting and analyzing complex networks helps one to grasp COVID-19 transmission dynamics. This work investigates the simulation and evaluation of the COVID-19 spread using multiple graph theory approaches. We utilize algorithms, including centrality assessments, community detection, and epidemic spreading models, to identify significant transmission channels and viable intervention sites; we also study the usage of network-building strategies to show relationships between individuals and communities. By incorporating real-world data with graph-based models, we demonstrate how these …

Artificial Intelligence-Powered Robotic Technology For Transforming Palliative Care, Adebo Thomas, Asiku Denis, Wamusi Robert, Simon Peter Kabiito, Zaward Morish, Aziku Samuel, Malik Sallam, Ioannis Adamopoulos

Mesopotamian Journal of Artificial Intelligence in Healthcare

Palliative care seeks to improve the quality of life of patients with life-threatening illnesses by addressing their physical, emotional, and psychological needs. However, global challenges such as workforce shortages, limited access to specialized care, and inconsistent care quality demand innovative solutions. Advances in artificial intelligence (AI)-powered robotics offer transformative potential to overcome these barriers and strengthen palliative care delivery. This study explores how AI-driven robotic technologies support palliative care through applications in symptom monitoring, clinical decision-making, emotional companionship, and personalized care planning. It reviews cutting-edge robotic systems, including assistive, companion, diagnostic, nursing, procedural, service, and rehabilitation robots. Enabled by machine …

Optimizing Decision Tree Classifiers For Healthcare Predictions: A Comparative Analysis Of Model Depth, Pruning, And Performance, Hussein Alkattan, Ali Subhi Alhumaima, Mohammed Shakir Mohmood, Ghassan Dhahir Mohammed Al-Thabhawee

Mesopotamian Journal of Artificial Intelligence in Healthcare

This study presents of Decision Tree classifiers for predictive modeling in medicine, focusing on model depth optimization, pruning techniques, and performance evaluation. On the basis of a synthetic healthcare dataset containing over 55,000 records, each with features such as age, gender, blood type, bill amount, and medical condition, we investigate the impact of varying tree depth from 1 to 5 on predictive accuracy, interpretability, and generalizability. Shallow models have strong transparency but poor classification strength, and deep models obtain stronger interactions but suffer from overfitting. With pruning, we find a balance between model simplicity and precision and yield strong classifiers …

Advancing Point-Of-Care Testing With Nanomaterials-Based Screen-Printing Electrodes, S. Nazir

School of Engineering, Computing and Mathematics

Although numerous studies have been conducted on multiple screen-printing electrodes (SPEs), little emphasis has been placed on systematically assessing scholarly work on nanomaterial-equipped SPEs in bioanalytical research. The fabrication of state-of-the-art portable screen-printing measuring devices represents significant disease monitoring and diagnosis advancements. This review classifies screen-printing electrodes based on the nanomaterials used. It discusses cost, regulatory approvals for portable screen-printing electrodes in point-of-care diagnostics, sensitivity, specificity, size reductions, and proposed solutions. It looks into the significance of new nanomaterials and substrates in fabricating point-of-care diagnostic devices and miniaturisation techniques. The review primarily focuses on the recent downsizing advances that have …

How Young Migrants Perceive School Health Education In Sweden, D. Barker, A. Caldeborg, M. Quennerstedt, Valeria Varea

Research outputs 2022 to 2026

The aim of this paper is to provide insights into how young people who have been forced to migrate perceive school health education. Eighteen individuals aged 15–19 years (10 females, 8 males, average age 16.9 years) took part in either focus group interviews (n = 7) or individual interviews (n = 1). Participants were first presented with short scenarios concerning health education and were invited to use these scenarios as starting points to discuss their own experiences of health education. Participants were then presented with a collection of photographs that portrayed people displaying broad dimensions of health. Participants were asked …

The Impact Of Opening A Private Hospital Emergency Department On The Hospital And Patient Characteristics, Christiana Mustac, John Maxwell, Paola Chivers, Gordon Laing, Terry Bayliss

Research outputs 2022 to 2026

Introduction Australian public hospital emergency departments (EDs) are under increasing pressure with higher patient volumes, failure to meet triage target times and increased ambulance wait times. Further, there is limited literature exploring how the opening of an ED affects Australian hospitals. This study focuses on Hollywood Private Hospital (HPH), a large private hospital in Western Australian which opened their ED in November 2021. The research aimed to examine how the introduction of the ED influenced the hospital’s service demands and resourcing. Method This study investigated hospital inpatient characteristics including admissions, clinical deterioration episodes, deaths, aft er-hours theatre activity and companion …

Improving Hpv Vaccine Rates For Aboriginal Young People Through A Social Media Campaign: An Interrupted Time Series, Natalie A. Strobel, Jocelyn Jones, Kim Gates, Simon L. Turner, Joanne E. Mckenzie, Daniel R. Mcaullay

Research outputs 2022 to 2026

Human papillomavirus (HPV) is a common sexually transmitted infection that can lead to HPV-related cancers such as cervical cancer and other cancers such as anal, vaginal, and penile cancer. HPV rarely produces symptoms and cannot be cured or treated; therefore, vaccination is essential to protect against HPV and HPV-related diseases. However, young Aboriginal and Torres Strait Islander (hereafter, respectfully, ‘Aboriginal’) people are not receiving their HPV vaccine dose, resulting in missed opportunities to be protected from HPV-related cancers. Health promotion is a critical way to empower people to take ownership over and control their health and is a core function …

Exploring The Sustainability Of Single Use Plastics In The Biopharmaceuticals Sector: A Scoping Review Of Challenges, Opportunities And Impact, Cormac Mcmahon, Adrienne F. M. Fleming, Philip Owende, Malcolm Goggin

Articles

Single-use plastics (SUPs) are synonymous with the biopharmaceuticals sector, facilitating economies of scale, process efficiency, flexibility and sterility assurance, all with a seemingly negligible environmental footprint. Yet, in ever-tightening regulation, mandated by the Sustainable Development Goals (SDGs) and by concern for large-scale industrial impacts, the sustainability of SUP consumption is increasingly being questioned. Whilst the sector contributes to human welfare, its transition risk is unlikely to remain immune to societal pressure for more sustainable production. This paper aims to present a scoping review of the apparent contradiction between sectoral SUP adoption and the increasing importance of circularity. The approach to …

Patient-Related And Tooth-Related Factors As Predictors For Tooth Loss In Periodontitis Patients: A Systematic Review, Cleane Daraze, Carole Chakar, Abdelrahman Kassir, Charbel Anka, Jean-Marie Megarbane

International Arab Journal of Dentistry

Introduction: The treatment of periodontitis aims to prevent further disease progression, to minimize symptoms and perception of the disease, possibly to restore lost tissues and to support patients in maintaining a healthy periodontium. Management of chronic periodontal disease requires a combination of therapeutic modalities and a lifelong commitment to periodontal self-care.

Objectives: The aim of this study is to evaluate predictors for tooth loss in patients previously diagnosed with periodontitis. This systematic review covers studies of over 10 years of follow up.

Methods: Electronic literature search was conducted on 19/02/2024 by one author across several databases, including …

Assessment Of The Psychometric Properties Of The Mask Usability Scale: A Measure Of The Perceived Usability Of N95 Respirators Among Healthcare Students And Staff, Lorna Kwai Ping Suen, Wai Hang Kwok, Ignatius Tak Sun Yu, Sony Nai Yeung So, Kin Cheung, Paul Hong Lee, Lily Yuen Wah Ho, Ka Yan Ko, Sukki Ho, Simon Ching Lam

Research outputs 2022 to 2026

Aim: To test the reliability and construct validity of the Mask Usability Scale in healthcare students and staff. Design: A methodological study involving repeated measures. Methods: The study included two batches of participants: (1) 283 university nursing students and (2) 1753 participants composed of students (61%) and clinical staff (39%). All participants underwent N95 respirator fit tests and user seal checks. They also responded to the Mask Usability Scale, which comprises 11 items evaluated using Likert scales. The internal consistency was assessed using Cronbach's alpha and item–total correlation test. Test–retest reliability was evaluated by the intraclass correlation coefficient (ICC). The …

The Impacts Of Covid-19 Restrictions On Care-Givers Of People With Cognitive Impairment And Their Support Needs: A Mixed-Methods Systematic Review, Loretta Baldassar, Thi N. M. Nguyen, Bronte Jones, Catriona Stevens, Lukasz Krzyzowski, Silvia Lozeva, Simone Marino, Maria G. C. Du Plooy, Johanne Eldridge, Osvaldo P. Almeida, Manonita Ghosh

Research outputs 2022 to 2026

The COVID-19 pandemic and ensuing restrictions/lockdowns have caused significant physical and psychological consequences for people with cognitive impairment who are heavily dependent on their care-givers. However, little is known about the impact on care-givers, the factors that exacerbate their situation and what supports they need. The aims of this paper are threefold: (a) to examine the impact of COVID-19 physical restrictions on both formal and informal care-givers of people with cognitive impairment; (b) to identify attributing factors influencing this impact; and (c) to recognise their support needs. Further, this paper informs future research, policy and practice. Guided by the Joanna …

Pla-Based Bone Tissue Engineering Scaffolds Incorporating Hydroxyapatite And Bioactive Glass Using Digital Light Processing, Engin Gepek, Fateme Fayyazbakhsh, Lev Suliandziga, Vadym Mochalin, Osman Iyibilgin, Yue-Wern Huang, Ming C. Leu

Chemistry Faculty Research & Creative Works

Bone tissue engineering (BTE) aims to repair bone defects using biocompatible materials with tailored geometries and pore structures, providing appropriate mechanical support and control over biodegradation kinetics to promote bone growth. In this study, we utilized digital light processing (DLP) 3D printing to fabricate scaffolds with varying pore sizes using polymer–ceramic slurries composed of polylactic acid (PLA) as the main polymer matrix, incorporated with hydroxyapatite (HA) and bioactive borate glass (BBG) at various ratios. We studied the effect of composition on rheological behavior, printability, mechanical properties, bioactivity, degradation rate, and biocompatibility. While HA increased viscosity and reduced printing accuracy, it …

A Historic Case Of Relapsing-Remitting Alzheimer's Disease In An Adolescent Attributed To Scarlet Fever., Richard Lathe, Brian J. Balin

PCOM Scholarly Works

We draw attention to a historic case of a boy who suffered from scarlet fever (typically caused by the bacterium Streptococcus pyogenes) at age 7 years and went on to develop the symptoms of Alzheimer's disease (AD). His physicians believed that the subsequent dementia was related to the infection. After death at 24 years of age, postmortem brain examination revealed abundant AD-type senile plaques and fibrils, formally confirming AD. Other potential causes of early-onset dementia are discussed, but these are distinct from patient E.H. This case is pertinent regarding the current debate about the potential role of infection in …

A Case Study Using The Transparency Framework And Artificial Intelligence To Promote Effective Writing And Student Success In A Writing-Intensive Course, Elizabeth A. Brown, Maria Kronenburg, Ashlee Steeley, Diana Tagbor

Health Behavior, Policy & Management Faculty Publications

Program evaluation data suggest that undergraduate students struggle with writing in a clear and concise manner and appropriately citing. Faculty implemented the plan-do study-act cycle to pilot the Transparency in Learning and Teaching (TILT) project framework and to explore the use of artificial intelligence (AI) and discuss approaches to using AI, along with the TILT framework, in a writing-intensive course to identify the pros and cons of using ChatGPT in an online classroom. The TILT framework reinforces adult learning by helping students clearly understand the assignment's purpose and establish a clear relationship between assignment and students' professional lives. Faculty encouraged …

Testing The Antigenic Potential Of Transmembrane Proteins To Develop A Thermostable Tuberculosis Mof-Liposomal Vaccine, Sneha Kumari, Jonathan Martinez-Garcia, Ryanne Nicole Ehrman, Wendy Tang, Joshua Miles, Priyanka Basak, Thomas Sinclair Howlett, Yalini Hansika Wijesundara, Ziqi Wang, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis is one of the deadliest infectious diseases and continues to be a major health risk in many parts of the world. Even today, the century-old Bacillus Calmette-Guerin (BCG) vaccine is the only formulation on the market and is ineffective for several sections of the global population responsible for transmission. In the search for antigens that can mount a robust immune response, we have reported the recombinant expression and purification of two novel membrane proteins, the Cation transporter protein V (CtpV) and the Mycobacterial copper transporter B (MctB) present on the membrane surface of Mycobacterium tuberculosis. CtpV was tested …

Multiplex Lateral Flow Test Sensitivity And Specificity In Detecting Influenza A, B And Sars-Cov-2 In Adult Patients In A Uk Emergency Department, Rahul Batra, Edward Blandford, Raghavendran Kulasegaran-Shylini, Matthias E Futschik, Abbie Bown, Matthew Catton, Hermione Conti-Frith, Alexandra Alexandridou, Rebecca Gill, Clara Milroy, Sean Harper, Holly Gettings, Maryann Noronha, Hooi-Ling Harrison, Sam Douthwaite, Gaia Nebbia, Paul E Klapper, Sarah Tunkel, Richard Vipond, Susan Hopkins, Tom Fowler

School of Biomedical Sciences

BACKGROUND: Rapid identification of individuals with acute respiratory infections is crucial for preventing nosocomial infections. For rapid diagnosis, especially in EDs, lateral flow devices (LFDs) are a convenient, inexpensive option with a rapid turnaround. Several 'multiplex' LFDs (M-LFDs) now exist, testing for multiple pathogens from a single swab sample. We evaluated the real-world performance of M-LFD versus PCR testing in detecting influenza A, B and SARS-CoV-2) in the ED setting.

METHODS: After preliminary evaluation of an M-LFD (SureScreen) with laboratory-grown virus and PCR-negative clinical samples, it was evaluated in a real-world setting at the ED of St Thomas' Hospital (London, …

Unvaccinated By Doubt: How Covid-19 Governance Sparked A Measles Revival, Ellen Black

FIU Law Review

A measles outbreak occurred in the United States this year, with measle cases reaching the highest levels in over two decades, even though the disease had been declared eliminated in 2000. In large part, this measles resurgence can be traced to unvaccinated individuals who have chosen to disregard public health officials' vaccination guidance. Clearly, the public has lost trust in their governmental public health officials. As the next disease outbreak looms, the need for restoration of trust becomes imperative.

This article demonstrates how the government's actions during COVID-19 further led to this lack of trust, by providing conflicting guidance as …

From Myriad To Moderna: The Modern (Bio)Pharmaceutical Company, Ana Santos Rutschman

Faculty Publications

This Article examines the emergence of two modern pharmaceutical companies: Myriad and Moderna. After providing a brief background on each company, this Article contrasts them across the following areas: the technologies they have brought to market; their location; their start-up stages and the role that venture capital played in catalyzing their evolution from start-ups to large corporate structures; their relationships with other entities in the private sector, in academia and in the public sector; and their intellectual property and licensing strategies.

Predictors Of Viral Suppression Among People Living With Hiv (Plhiv) On Antiretroviral Treatment In Almaty, Kazakhstan, Ainur Kussainova

Electronic Theses & Dissertations (2024 - present)

ABSTRACT

Introduction

The Eastern Europe and Central Asia (EECA) region is experiencing the world’s fastest-growing HIV epidemic, with Kazakhstan among the countries most affected. Despite progress in HIV testing and treatment, Kazakhstan continues to face significant challenges in achieving optimal viral suppression among PLHIV. While 82% of PLHIV in Kazakhstan know their HIV status, only 73% are on ART, and just 67% of those on treatment achieve viral suppression. Adherence to ART remains a critical barrier, influenced by a complex interplay of individual, social, and structural factors, including mental health disorders such as depression, substance use, stigma and discrimination. Understanding …

Kafka In The Plague Years: Reinterpreting Absurdity In The 2020s, Chris Lownie

Electronic Theses & Dissertations (2024 - present)

No word better encapsulates the confusion and inequality proliferating in the post-2020 global world than “absurd.” Absurdity consumes the way we interact with one another, going about life-as-usual in pocket worlds in which the individual is alienated from both oneself and others. Life is defined by a series of problems that regularly go ignored by both institution and general populace alike, but not by the human body: the effects of sustained illness and reinfection by recurrent viruses in a world that no longer acknowledges their severity nor their pervasiveness nor steps we may take towards personal safety. Daily life has …

Ribosome Hibernation In Mycobacterium Abscessus And Its Effect On Antibiotic Resistance, Ryan Treen

Electronic Theses & Dissertations (2024 - present)

Non-tuberculosis mycobacteria (NTM) represent a diverse repertoire of species, most of which are ubiquitous in the environment. Some NTM species, such as Mycobacterium abscessus, can cause life-threatening infections in people with underlying medical conditions. The clinical incidence of such infections is on the rise, posing an emerging threat to public health. M. abscessus is characterized by intrinsic and acquired antibiotic resistance, complicating treatment strategies. Most chemotherapeutic approaches for M. abscessus infection target the bacterial ribosome, necessitating a better understanding of the physiological processes which confer this resistance. Multiple mycobacterial species respond to zinc-limiting conditions by inducing remodeling and hibernation …

Polygenic Risk Scores Of Grip Strength In Men And Women With Or At Risk For Hiv, Sreevidya Sadananda Sadasiva Rao

Electronic Theses & Dissertations (2024 - present)

Background: Adequate hand function among older adults is necessary for the successful completion of activities of daily living and can affect whether an older adult is able to live independently. Current research highlights grip strength, the strength people have in their hands, as a robust predictor of morbidity and mortality, and explores the decline in grip strength over time. A person’s family history and genes (DNA) affect how much grip strength they have. Previous studies have identified genes that affect grip strength, mainly in European ancestry populations. In this study, we examined whether these genetic elements predict grip strength in …

Association Of Non-Communicable Diseases With Severe Covid-19 Among People Living With And Without Diagnosed Hiv/Aids In New York State, Ravi Kumar Balu

Electronic Theses & Dissertations (2024 - present)

Background: People living with diagnosed HIV (PLWDH) have a higher chance of co-infections and co-morbidities than the general population. When SARS-CoV-2 was first reported in China in December 2019 and later declared a pandemic, it was speculated that PLWDH might be more prone to SARS-CoV-2 infection and severe disease outcomes given their increased vulnerability to other respiratory infections like influenza, pneumococcal pneumonia and tuberculosis. However, several facets of COVID-19 disease in PLWDH are incompletely understood, including whether non-communicable diseases (NCDs) are strong risk factors for severe disease outcomes and death as they are in the general population.

Methods: The data …

How Do Young Adults With Drug Use Disorder (Dud) Utilize Treatment? Exploring And Examining Lived Experiences Towards Treatment Completion In Indonesia, Dewi Kartikawatiningsih

Electronic Theses & Dissertations (2024 - present)

In Indonesia which has the highest rate of drug addiction in Southeast Asia, there is currently little knowledge about how young adults perceive the barriers faced when completing treatment or how treatment providers' perspectives influence their treatment completion. Understanding and identifying barriers to treatment completion is essential to making drug treatment more effective. The purpose of this study is to explore the perspectives and live experiences of young adults with DUD and their addiction counselors to develop a deeper understanding of treatment needs. This study interviewed 33 clients and 15 counselors from the rehabilitation center of the Badan Nasional Narkotika …