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Articles 5881 - 5910 of 73649
Full-Text Articles in Entire DC Network
Assessment Of Bio-Security Knowledge, Attitude And Hygienic Practices Among Smallholder Chicken Farmers In Southern Mozambique, Noémia André Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia
Assessment Of Bio-Security Knowledge, Attitude And Hygienic Practices Among Smallholder Chicken Farmers In Southern Mozambique, Noémia André Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia
All Rsif Scholars' Publications
The production of broiler chickens in intensive systems struggles to maintain hygiene in production, despite contributing to combating malnutrition, generating employment, and increasing family income, especially in developing countries. Using a structured questionnaire survey, a cross-sectional study was carried out among 395 smallholder farmers to evaluate their knowledge, attitudes, and practices related to farm biosecurity in urban and peri-urban areas of Mozambique and determine the factors affecting KAP (knowledge, attitude, and practice) levels. Data were analyzed using Statistical Package for Social Science (SPSS) (IBM version 27). The findings indicate that education level and training significantly influence (p < 0.001) food safety in terms of biosecurity knowledge, attitudes, and practices. Smallholders who attended food safety training exhibited positive attitudes (95.5%, mean score of 89.71 ± 10.1) in contrast to those who did not participate in training (74.8%, mean score of 79.91 ± 9.68). Additionally, washing hands with soap before and after using the toilet and wearing protective clothing during chicken husbandry were significantly associated with education level (χ² = 15.345, P = 0.018); those with informal education were 34% less likely to have a negative attitude toward food safety compared to those with high education. A significant correlation (p < 0.01) was observed between residence area, training, and biosecurity knowledge, attitude, and practice. Because smallholders lack training, hygiene expertise, and biosecurity practices on their farms, this study concluded that they pose a risk to public health and food safety. To maintain consumer health and guarantee food safety, farmers should properly dispose of waste, including dead chickens, and receive continuous training in excellent biosecurity measures on the farm
Antibiotic Use And Antimicrobial Resistance: Knowledge, Attitudes, And Practices Among Smallholder Chicken Farmers In Southern Mozambique, Noemia Andre Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia
Antibiotic Use And Antimicrobial Resistance: Knowledge, Attitudes, And Practices Among Smallholder Chicken Farmers In Southern Mozambique, Noemia Andre Mugabe, Jamal Kussaga, Abdulsudi Issa-Zacharia
All Rsif Scholars' Publications
Intensive production systems face challenges in treating individual chickens due to the large number of animals, resulting in the indiscriminate use of antibiotics as the only alternative. The use of antibiotics in poultry production has adverse effects on humans, as prolonged consumption of contaminated meat can lead to the development of antibiotic resistance in intestinal bacteria. A cross-sectional survey involving 395 smallholder farmers was conducted through face-to-face interviews to assess knowledge, attitudes, and practices (KAP) regarding antibiotic use in urban and peri-urban areas of Southern Mozambique. Data were analyzed using SPSS version 27. The findings revealed that 60% of respondents …
Identification Of Potential Vectors And Detection Of Rift Valley Fever Virus In Mosquitoes Collected Before And During The 2022 Outbreak In Rwanda, Isidore Nsengimana, Emmanuel Hakizimana, Jackie Mupfasoni, Jean Nepomuscene Hakizimana, Augustino A. Chengula, Christopher J. Kasanga, Gillian Eastwood
Identification Of Potential Vectors And Detection Of Rift Valley Fever Virus In Mosquitoes Collected Before And During The 2022 Outbreak In Rwanda, Isidore Nsengimana, Emmanuel Hakizimana, Jackie Mupfasoni, Jean Nepomuscene Hakizimana, Augustino A. Chengula, Christopher J. Kasanga, Gillian Eastwood
All Rsif Scholars' Publications
Rift Valley fever virus (RVFV) is an emerging mosquito-borne arbovirus of One Health importance that caused two large outbreaks in Rwanda in 2018 and 2022. Information on vector species with a role in RVFV eco-epidemiology in Rwanda is scarce. Here we sought to identify potential mosquito vectors of RVFV in Rwanda, their distribution and abundance, as well as their infection status. Since an outbreak of RVF occurred during the study period, data were obtained both during an interepidemic period and during the 2022 Rwanda RVF outbreak. Five districts of the eastern province of Rwanda were prospected using a combination of …
Advancing Sustainable Practices: Integrated Pedological Characterization And Suitability Assessment For Enhanced Irish Potato Production In Tsangano And Angónia Districts Of Tete Province, Mozambique., Tamara Jose Sande, Balthazar Michael Msanya, Hamisi Juma Tindwa, Alessandra Mayumi Tokura Alovisi, Johnson M. Semoka, Mawazo Shitindi
Advancing Sustainable Practices: Integrated Pedological Characterization And Suitability Assessment For Enhanced Irish Potato Production In Tsangano And Angónia Districts Of Tete Province, Mozambique., Tamara Jose Sande, Balthazar Michael Msanya, Hamisi Juma Tindwa, Alessandra Mayumi Tokura Alovisi, Johnson M. Semoka, Mawazo Shitindi
All Rsif Scholars' Publications
Irish potato (Solanum tuberosum) is a critical crop for food security and economic growth in Tsangano and Angónia Districts, Central Mozambique. Challenges like inconsistent yields and variable quality are often linked to suboptimal soil conditions, which limit production. This study aimed to classify and evaluate the suitability of soils for potato cultivation in Tete Province, where detailed soil assessments remain limited. Four pedons—TSA-P01 and TSA-P02 in Tsangano and ANGO-P01 and ANGO-P02 in Angónia—were examined for bulk density, texture, pH, organic carbon, and nutrient content using a combination of pedological methods and laboratory soil analysis. To determine each site’s potential for …
Fermentation, Handling And Claimed Therapeutic Effects Of Dhanaan: An Ethiopian Fermented Camel Milk, Tiruha Habte Karssa, Jamal B. Kussaga, Teresa Lemsaddek Lemsaddek, Jovin K. Mugula
Fermentation, Handling And Claimed Therapeutic Effects Of Dhanaan: An Ethiopian Fermented Camel Milk, Tiruha Habte Karssa, Jamal B. Kussaga, Teresa Lemsaddek Lemsaddek, Jovin K. Mugula
All Rsif Scholars' Publications
Dhanaan is a spontaneously fermented camel milk that is popular in the Somali regional state of Ethiopia and plays a sig- nificant role in the livelihoods of pastoral communities. This study aimed to investigate traditional fermentation methods of dhanaan in these communities. Four districts, namely, Gursum, Shabelle, Degehabur, and Birqot, were purposively selected on the basis of camel rearing, camel milk production, and consumption. A cross-sectional survey of traditional fermentation methods, handling, utilization, and the claimed therapeutic effects of dhanaan was conducted using both open- and closed- ended questions in the districts. The traditional preparation of dhanaan involves spontaneous fermentation …
The Role Of Tgf-Beta Superfamily Members In Immune Homeostasis And Disease, Natalie Eva Nieuwenhuizen, Ioannis Eleftherianos, Piotr Jan Kraj, Maria Semitekolou
The Role Of Tgf-Beta Superfamily Members In Immune Homeostasis And Disease, Natalie Eva Nieuwenhuizen, Ioannis Eleftherianos, Piotr Jan Kraj, Maria Semitekolou
Biological Sciences Faculty Publications
[Introduction] The Transforming Growth Factor beta (TGF-beta) superfamily, encompassing molecules such as TGFs, activins, Bone Morphogenetic Proteins (BMPs), Growth/Differentiation Factor (GDFs) and Nodals, represents the largest family of growth and differentiation factors, playing crucial roles in developmental and physiological processes across animal species (1). These molecules are integral to tissue homeostasis and cell fate determination. Among them, TGF-beta is particularly noted for its regulatory influence on immune responses and tissue fibrosis (2, 3). Recent research has expanded our understanding of the immune functions of other superfamily members, including activin A and BMPs (4). These molecules signal through receptor complexes composed …
From Proposal To Podcast: Starting A Student-Driven Pharmacy Podcast In The Classroom, Jarett C. Worden, Jennifer Duck
From Proposal To Podcast: Starting A Student-Driven Pharmacy Podcast In The Classroom, Jarett C. Worden, Jennifer Duck
Funded Scholarship
Background: Podcasts are a widely available and popular educational medium for healthcare providers, residents, students, and patients. Podcasts are convenient, accessible, and may be effective education tools for listeners. While some studies have attempted to measure the effectiveness of podcasting to enhance knowledge, there are few studies evaluating podcasts in pharmacy education. The purpose of this project was to provide students with the opportunity to create a podcast episode through an in-class, semester-long assignment and to evaluate student perceptions of knowledge, confidence, and professional identity.
Educational activity: Over the course of a semester-long elective class, students worked in groups to …
Exploring Stress, Fatigue, Burnout, And Resilience Among Healthcare Personnel In Southeast Asia: A Scoping Review, Kelsey Trulik, Vijaya Arun Kumar, Wendy Wu, Muralidhar Varma, Mauli M. Patel, Kajol Manglani, Trini A. Mathew
Exploring Stress, Fatigue, Burnout, And Resilience Among Healthcare Personnel In Southeast Asia: A Scoping Review, Kelsey Trulik, Vijaya Arun Kumar, Wendy Wu, Muralidhar Varma, Mauli M. Patel, Kajol Manglani, Trini A. Mathew
Global Health Research Collaborative
This study aims to compare methods used to measure burnout, fatigue, stress, and resilience, as well as resilience-building interventions among healthcare personnel (HCP) in Southeast Asia. Even before COVID-19, HCP faced high levels of burnout and stress, exacerbated by the pandemic. Identifying effective resilience-building strategies is essential to supporting a healthier workforce. Studies published from January 2016 to December 2021 focusing on burnout, stress, fatigue, and resilience in HCP in Southeast Asia. A comprehensive literature search of seven databases (Jan 2016-Dec 2021), using terms related to resilience, HCP, and Southeastern Asian countries identified relevant English-language studies. COVIDENCE software was used …
How Community Members In Uganda Perceive Controlled Human Infection Studies, Winfred Nazziwa, Stella Neema, Alison Elliot, Samson B. Kaboko, Julius Ecuru, Erisa Mwaka
How Community Members In Uganda Perceive Controlled Human Infection Studies, Winfred Nazziwa, Stella Neema, Alison Elliot, Samson B. Kaboko, Julius Ecuru, Erisa Mwaka
All Peer-Reviewed Publications
Controlled Human Infection studies are a new and uncommon way of conducting clinical research in low resource settings. Regardless of the supposed importance of human infection studies in advancing clinical research, there is still limited literature on community perceptions of this field of research, particularly in low-resource settings. An exploratory qualitative study involving 107 community members organized into 16 focussed groups was conducted in Kampala city and Buikwe district in central Uganda between September 2023 and March 2024. The groups comprised market vendors, secondary school teachers, university students, media professionals/journalists, mosques/church attendants and Community Advisory Board members. Data were analysed …
Normative Laboratory Value Ranges In Pediatric Patients Who Underwent Evaluation For Mis-C, Thomas Graf, Nathan M Money, Sindhoosha Malay, Nori Minich, Risa Bochner, Bari Winik, Ron Kaplan, Jennifer Y Colgan, Erin Aldag, Ryan O' Sullivan, Guliz Erdem, Allayne Stephans
Normative Laboratory Value Ranges In Pediatric Patients Who Underwent Evaluation For Mis-C, Thomas Graf, Nathan M Money, Sindhoosha Malay, Nori Minich, Risa Bochner, Bari Winik, Ron Kaplan, Jennifer Y Colgan, Erin Aldag, Ryan O' Sullivan, Guliz Erdem, Allayne Stephans
Faculty, Staff and Student Publications
Background and objectives: Diagnosis of multisystem inflammatory syndrome in children (MIS-C) is challenging due to symptom overlap with other common conditions. The primary objective of this multicenter study was to establish normative laboratory values in MIS-C patients and compare to patients evaluated for MIS-C who had other final diagnoses.
Methods: Five hospitals reviewed records of a cohort of patients 6 months to 18 years old who were evaluated for MIS-C between March 31st 2020 and February 1st 2022. Patient demographics, clinical presentation, and laboratory values were compared in patients with a final diagnosis of MIS-C versus all other conditions. Patients' …
The Effects Of Salinity On The Cutaneous Microbiome And Pathogen Infection On The Pacific Tree Frog (Pseudacris Regilla) In Monterey Bay, California, Usa, Hannah Eunhae Kim
The Effects Of Salinity On The Cutaneous Microbiome And Pathogen Infection On The Pacific Tree Frog (Pseudacris Regilla) In Monterey Bay, California, Usa, Hannah Eunhae Kim
EWU Masters Thesis Collection
Global climate change and infectious diseases are considered a leading cause of amphibian population declines worldwide. Changes in precipitation and salinity have altered watershed systems and microbial communities, reducing habitat availability and physiological performances for amphibian survival. The salt refuge hypothesis, however, is a proposed explanation that higher saline environments may reduce susceptibility to pathogens such as Batrachochytrium dendrobatidis (Bd). The Moro Cojo Slough State Marine Reserve (MCSSMR) (California, USA) is known as an abundant breeding ground for endangered/threatened amphibian species. To test and expand the salt refuge hypothesis, I evaluated Bd prevalence and intensity and the cutaneous microbiome of …
Characterization Of The Biofilm-Forming Ability And Certain Virulence Characters Ofaeromonas Spp. Isolates From Rainbow Trout, Türker Çelebi̇, Ertan Emek Onuk, Esra Demi̇rbaş, Gökçen Di̇nç
Characterization Of The Biofilm-Forming Ability And Certain Virulence Characters Ofaeromonas Spp. Isolates From Rainbow Trout, Türker Çelebi̇, Ertan Emek Onuk, Esra Demi̇rbaş, Gökçen Di̇nç
Turkish Journal of Veterinary & Animal Sciences
Aeromonas spp., commonly found in the aquatic environment, cause infections in both fish and humans. Their pathogenicitydepends on various virulence factors and ability to form biofilm. The current study aimed to determine the biofilm-forming capabilitiesand certain virulence characteristics of 25 Aeromonas spp. isolates obtained from rainbow trout in Türkiye. The biofilm-forming abilitiesof isolates were investigated comparatively using Congo red agar (CRA), the tube method (TM), and tissue culture plates (TCPs).Potential virulence factors, including hemolytic activity, gelatinase production, serine protease activity, DNase activity, and motility,were evaluated using phenotypic tests. Additionally, the distribution of four known virulence genes, namely aerA, exu, fla, …
Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol
Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol
Turkish Journal of Veterinary & Animal Sciences
Organic acids (OAs) and essential oils (EOs) have several positive effects on the gut microbiota of broilers. In this study, weaimed to determine the efficacy of a blend of protected OAs and EOs [P(OA+EO)] on the growth performance and cecal microbiota ofbroiler chickens. A total of 160 Ross 308 broiler chickens, including 80 male and 80 female birds, all 1 day old, were randomly distributedbetween the control group (basal diet) and the treatment group [basal diet + 300 g/t P(OA+EO)] according to an 8-pen arrangementwith 4 replicates of 20 birds. Body weight (BW), body weight gain (BWG), feed consumption (FC), …
In-Person Versus Peer-Coordinated Virtual Health Coaching For Metabolic And Behavioral Outcomes In Women In Sober Living Facilities, Craig R. Witt
In-Person Versus Peer-Coordinated Virtual Health Coaching For Metabolic And Behavioral Outcomes In Women In Sober Living Facilities, Craig R. Witt
Dissertations
Background: Women in early recovery from substance use disorder often face metabolic health vulnerabilities, yet physical health behaviors are frequently under-emphasized in sober living settings. Feasible and accessible wellness strategies are needed to support both behavioral and metabolic health in this population.
Purpose: To compare the effects of professionally delivered in-person health coaching versus peer-coordinated virtual health coaching on metabolic outcomes and health-promoting behaviors among women in sober living facilities.
Methods: In this quasi-experimental study, 32 women enrolled in a 12-week group-based health coaching program focused on nutrition, physical activity, and stress management; 18 completed post-intervention assessments (in-person: n = …
High-Binding Affinity Nanobody Against Sars-Cov-2 Xbb.1.5: Computational-Based Protein Engineering, Phoomintara Longsompurana, Napat Kongtaworn, Rungtiva P. Poo-Arporn, Thanyada Rungrotmongkol
High-Binding Affinity Nanobody Against Sars-Cov-2 Xbb.1.5: Computational-Based Protein Engineering, Phoomintara Longsompurana, Napat Kongtaworn, Rungtiva P. Poo-Arporn, Thanyada Rungrotmongkol
Journal of Metals, Materials and Minerals
The emergence of the SARS-CoV-2 variant XBB.1.5 has triggered a global health crisis by enhancing viral entry into cells via its spike protein. This study addresses the urgent need to develop neutralizing nanobodies (Nbs) to counteract the SARS-CoV-2 virus. Our aim was to identify a lead Nb and enhance its binding affinity to the receptor-binding motif (RBM) on the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (S-protein) using computational methods. A total of 29 Nbs were screened against the XBB.1.5 RBD using the HDOCK server to select a lead Nb. This investigation revealed that Nb_7KGK exhibited the highest binding …
The Aga Khan University Prospectus 2025, The Aga Khan University
The Aga Khan University Prospectus 2025, The Aga Khan University
The Aga Khan University Prospectuses and Brochures
- Message from the President
- Message from the Provost & Vice President, Academic
- About AKU
- Our Mission, Vision & Values
- Why AKU?
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Programmes of Study
Undergraduate Programmes
- School of Nursing and Midwifery, East Africa
- School of Nursing and Midwifery, Pakistan
- Medical College, East Africa
- Medical College, Pakistan
- Faculty of Arts and Sciences, Pakistan
- Institute for Educational Development, Pakistan
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Graduate Programmes
- School of Nursing and Midwifery, East Africa
- School of Nursing and Midwifery, Pakistan
- Institute for Educational Development, East Africa
- Institute for Educational Development, Pakistan
- Medical College, East Africa
- Medical College, Pakistan
- Graduate School of Media and Communications, East Africa
- Institute for …
Comparative Analysis Of Hydration Status And Microbial Quality Of Tap Water Between Urban And Rural Settings In The Ashanti Region Of Ghana, Marina A. Tandoh, Priscilla Owusu, Claire-Rush N.A. Nkrumah, Veronica Tawiah Annaful, Chris Y. Asare, Samuel Selormi Attu
Comparative Analysis Of Hydration Status And Microbial Quality Of Tap Water Between Urban And Rural Settings In The Ashanti Region Of Ghana, Marina A. Tandoh, Priscilla Owusu, Claire-Rush N.A. Nkrumah, Veronica Tawiah Annaful, Chris Y. Asare, Samuel Selormi Attu
Food Science Faculty Publications and Presentations
Maintaining proper hydration is crucial for human health, physiological functions, and cognitive performance. This study sought to determine the hydration status and the microbial safety of tap water in an urban setting (Kwame Nkrumah University of Science and Technology Campus) and a rural community (Adjamesu) in the Ashanti Region of Ghana. The water safety perception and hydration status of 171 study participants aged 10-61 years were assessed. Six taps were randomly selected at each site in triplicates, resulting in 36 water samples. The microbial quality of the water was assessed by testing for heterotrophic bacteria, coliforms, Staphylococcus aureus, and Salmonella. …
Thermal Inactivation Of E. Faecium On Ground Poultry, Joseph Katz
Thermal Inactivation Of E. Faecium On Ground Poultry, Joseph Katz
Graduate Theses, Dissertations, and Problem Reports (ETD)
Chicken products in grocery stores are contaminated with Salmonella that is ranked number one as a foodborne pathogen, and causes about 1.35 million cases of foodborne illness, 26,500 hospitalizations, and 420 deaths annually. The objective of this study is to determine thermal kinetic parameters of Salmonella surrogate bacteria E. faecium in ground poultry as affected by different temperatures and salt concentrations. The raw chicken was sliced up into a 500 g batch with a total of 6 batches per replicate, ground up in the meat grinder followed by inoculation with E. faecium resistant to 200 ppm Nalidixic Acid. NaCl …
Characterizing A Free-Roaming Cat Population To Predict Predation Of Threatened Species In An Island Ecosystem, Sarah Gheida
Characterizing A Free-Roaming Cat Population To Predict Predation Of Threatened Species In An Island Ecosystem, Sarah Gheida
Electronic Theses and Dissertations
No abstract provided.
Grand Challenges For Human Factors And Ergonomics, Waldemar Karwowski, Gavriel Salvendy, Mica Endsley, William Rouse, Paul Salmon, Kay Stanney, Andrew Thatcher, Tony Andre, Jessie Yang, Hasan Ayaz, Ahmet Cakir, Vince Duffy, Colin Drury, Qin Gao, Yinni Guo, Peter Hancock, William S. Marras, Patrick Rau
Grand Challenges For Human Factors And Ergonomics, Waldemar Karwowski, Gavriel Salvendy, Mica Endsley, William Rouse, Paul Salmon, Kay Stanney, Andrew Thatcher, Tony Andre, Jessie Yang, Hasan Ayaz, Ahmet Cakir, Vince Duffy, Colin Drury, Qin Gao, Yinni Guo, Peter Hancock, William S. Marras, Patrick Rau
Faculty Research, Scholarly, and Creative Activity
Contemporary society faces a growing set of complex global issues representing significant human health, well-being, and sustainability threats. Human Factors and Ergonomics (HFE) has a critical role to play in responding to these issues; however, there remain a set of grand challenges that require resolution. This paper presents and discusses six grand challenges for HFE and related key research thrust areas for each of the challenges. The grand challenges are (1) Evolution in Societal Thinking; (2) Future of Human Work in Industry 5.0; (3) Climate Change and Sustainability; (4) Future of Education and Training; (5) Future of Personalized Health, and …
Predictive And Generative Modeling For Biomedical Data Analytics, Magdalyn E. Elkin
Predictive And Generative Modeling For Biomedical Data Analytics, Magdalyn E. Elkin
Electronic Theses and Dissertations 2020 - Present
Biomedical data analytics is a broad interdisciplinary field that has seen vast amounts of data collected with recent technological advancements. Computational studies are required for time and cost-efficient methods to characterize, summarize, and interpret these datasets to advance public health. This thesis presents research studies done with predictive and generative models with regards to subdomains in clinical research, healthcare and bioinformatics. Our research with predictive modeling presents (1) extensive feature engineering methods, ensemble models and feature selection ranking in order to provide data-driven models to evaluate relevant evidence for clinical decision making; and (2) network analysis and unsupervised link prediction …
Bakterielle Schutzmechanismen Gegen Hypochlorige Säure, Jan-Ulrik Dahl
Bakterielle Schutzmechanismen Gegen Hypochlorige Säure, Jan-Ulrik Dahl
Faculty Publications – Biological Sciences
Reactive chlorine species (RCS) are highly bactericidal and produced in large amounts during host defense to kill invading pathogens. More recent studies have investigated how bacteria respond to and defend RCS, which appear to elicit more multifaceted responses compared to reactive oxygen species. A comprehensive understanding of bacterial RCS responses has clear potential to devise strategies that increase the sensitivity of bacterial pathogens to host defenses without harming commensals.
Microplastics In Coastal Sediments, Halaina Hahn
Microplastics In Coastal Sediments, Halaina Hahn
Electronic Theses and Dissertations 2020 - Present
Marine and coastal sediments are considered to be sinks for plastic pollution. The dispersal of microplastics through ocean dynamics (winds, waves, currents, and tides) may be dependent on the type of microplastic and sedimentation of the coastal environment. Coastal tourism significantly contributes to the sources of plastic, especially in the state of Florida. Microplastic pollution impacts all facets of the environment impacting ecosystem services, wildlife, and human health. However, few studies have been conducted to quantify the abundance and type of microplastics found in coastal sediments under different seasonal conditions. This project aimed to evaluate the abundance of microplastics in …
Multiscale Modeling Of Infectious Diseases: Identifiability Framework For Parameter Estimation And Model Validation, Ambegoda Liyanage
Multiscale Modeling Of Infectious Diseases: Identifiability Framework For Parameter Estimation And Model Validation, Ambegoda Liyanage
Electronic Theses and Dissertations 2020 - Present
Understanding and controlling the spread of infectious diseases requires integrative mathematical models that connect biological processes across multiple scales, from individual-level transmission dynamics to population-level epidemic behavior. In this work, we develop and analyze multiscale mathematical models to investigate the transmission of emerging and re-emerging infectious diseases, with a strong focus on structural and practical identifiability to ensure model reliability.
We begin by investigating the transmission dynamics of the Usutu virus (USUV), an emerging mosquito-borne virus of growing concern in Europe and Africa. Understanding the epidemiology of such pathogens requires a systems-level approach that captures biological processes across multiple scales, …
Invasive Fungal Disease In Solid Organ And Hematopoietic Cell Transplant Recipients, United States, Jeremy A W Gold, Kaitlin Benedict, Elizabeth Sajewski, Tom Chiller, Meghan Lyman, Mitsuru Toda, Jessica S Little, Luis Ostrosky-Zeichner
Invasive Fungal Disease In Solid Organ And Hematopoietic Cell Transplant Recipients, United States, Jeremy A W Gold, Kaitlin Benedict, Elizabeth Sajewski, Tom Chiller, Meghan Lyman, Mitsuru Toda, Jessica S Little, Luis Ostrosky-Zeichner
Faculty, Staff and Student Publications
Background: Updated benchmark data on invasive fungal disease (IFD) in solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT) recipients are necessary to increase clinical recognition and inform treatment and prevention strategies. We estimated IFD incidence and potential risk factors in transplant recipients in a large US commercial health insurance database.
Methods: We observed patients who received SOT or HCT during 2018-2022 until IFD development, disenrollment, or database end date (July 31, 2023). We calculated incidence (per 1000 person-years) and time to IFD development, comparing demographic features and underlying conditions for IFD versus non-IFD patients.
Results: Overall, 9143 patients received …
National Healthcare Safety Network… We Need To Talk…., Misti Ellsworth, Luis Zeichner Ostrosky, Bela Patel, Robert Yetman, Phillip Chang
National Healthcare Safety Network… We Need To Talk…., Misti Ellsworth, Luis Zeichner Ostrosky, Bela Patel, Robert Yetman, Phillip Chang
Faculty, Staff and Student Publications
No abstract provided.
Multisociety Guidance For Infection Prevention And Control In Nursing Homes, Lona Mody, Sonali D. Advani, Muhammad Salman Ashraf, Allison H. Bartlett, Suzanne F. Bradley, Deborah P. Burdsall, Jennifer A. Hanrahan, Susan S. Huang, Robert L.P. Jump, Lindsay Nicolle, Mary-Claire Roghmann, Patricia Stone, Rekha K. Murthy
Multisociety Guidance For Infection Prevention And Control In Nursing Homes, Lona Mody, Sonali D. Advani, Muhammad Salman Ashraf, Allison H. Bartlett, Suzanne F. Bradley, Deborah P. Burdsall, Jennifer A. Hanrahan, Susan S. Huang, Robert L.P. Jump, Lindsay Nicolle, Mary-Claire Roghmann, Patricia Stone, Rekha K. Murthy
Department of Medicine Faculty Publications
This multisociety guidance was endorsed by SHEA, APIC, IDSA, PALTmed, and AGS. It provides recommendations for infection prevention and control (IPC) in the context of the complexity of nursing home care in the United States: increased medical acuity of residents, the spread of multidrug-resistant organisms, and the threat of emerging pathogens. Recommendations and implementation suggestions address IPC leadership, staffing, and resources, healthcare personnel and residents‘ adherence to precautions and effective hand hygiene, outbreak preparedness, training, occupational health, cleaning and disinfection in the care environment, and the involvement of IPC in the facility. The guidance also addresses the challenges of maintaining …
Development, Delivery, And Evaluation Of The Texas Epidemic Public Health Institute Pilot Infection Control Lecture Series, Kayla E Ruch, Anabel Rodriguez, Janelle Rios, Luis Ostrosky-Zeichner, Eric L Brown
Development, Delivery, And Evaluation Of The Texas Epidemic Public Health Institute Pilot Infection Control Lecture Series, Kayla E Ruch, Anabel Rodriguez, Janelle Rios, Luis Ostrosky-Zeichner, Eric L Brown
Faculty, Staff and Student Publications
Introduction: The Texas Epidemic Public Health Institute (TEPHI) aims to keep Texans healthy and the economy strong by preparing for the next infectious disease outbreak. TEPHI's Small Rural Healthcare Preparedness core developed, delivered, and evaluated a pilot infection prevention and control webinar series called Infection Control for rural-serving health professionals and organizations based on infection prevention and control field best practices.
Methods: Data from the first year of the Infection Control series was collected through attendee registration forms, attendance records, knowledge, and post-lecture evaluation surveys using Qualtrics. The data were analyzed using Qualtrics software. Lectures were free and open to …
Rates Of Multidrug-Resistant Gram-Negative Bacterial Infections In Hospitalized Non-Immunocompromised Pediatric Patients: A 9-Year Retrospective Study At A Lebanese Tertiary Medical Center, Ramia Zakhour, Sarah Khafaja, Rawan Korman, Celina F Boutros, Zeinab El Zein, Ahmad Chmaisse, Magda Haj, Amani Haddara, Zeina El-Houry, Malak Jbahi, Sarah Chamseddine, Samer Bou Karroum, Dana Al Oweini, Yolla Salama Youssef, Nour Youssef, Mayse Nasser, Danielle Fayad, Farida Abi Farraj, Clara El Nakib, Imad Isaac, Mireille Lteif, George F Araj, Ghassan S Dbaibo
Rates Of Multidrug-Resistant Gram-Negative Bacterial Infections In Hospitalized Non-Immunocompromised Pediatric Patients: A 9-Year Retrospective Study At A Lebanese Tertiary Medical Center, Ramia Zakhour, Sarah Khafaja, Rawan Korman, Celina F Boutros, Zeinab El Zein, Ahmad Chmaisse, Magda Haj, Amani Haddara, Zeina El-Houry, Malak Jbahi, Sarah Chamseddine, Samer Bou Karroum, Dana Al Oweini, Yolla Salama Youssef, Nour Youssef, Mayse Nasser, Danielle Fayad, Farida Abi Farraj, Clara El Nakib, Imad Isaac, Mireille Lteif, George F Araj, Ghassan S Dbaibo
Faculty, Staff and Student Publications
Introduction: Multidrug resistant (MDR) Gram-negative bacterial infections are considered a major public health threat. The objectives of this study were to describe the epidemiology, potential contributing factors, and antimicrobial resistance patterns associated with infections caused by MDR Gram-negative bacteria (GNB) in non-immunocompromised children and adolescents.
Methods: This was a retrospective observational study conducted at the American University of Beirut Medical Center (AUBMC) from 2009 to 2017. The study included non-immunocompromised patients 18 years of age or younger with infections caused by GNB isolated from a sterile site or nonsterile site in the setting of clinical infection.
Results: A total of …
Decline In Attrition Rates In United States Pediatric Residency And Fellowship Programs, 2007–2020: A Repeated Cross-Sectional Study, Emma Omoruyi, Greg Russell, Kimberly Montez
Decline In Attrition Rates In United States Pediatric Residency And Fellowship Programs, 2007–2020: A Repeated Cross-Sectional Study, Emma Omoruyi, Greg Russell, Kimberly Montez
Faculty, Staff and Student Publications
Purpose: Declining fill rates in US pediatric residency and subspecialty programs requires trainee retention. Attrition, defined as transfers, withdrawals, dismissals, unsuccessful completions, or deaths, disrupts program function and impacts the pediatric workforce pipeline. It aims to evaluate attrition trends among pediatric residents and fellows in Accreditation Council for Graduate Medical Education (ACGME)-accredited programs from 2007 to 2020.
Methods: This repeated cross-sectional study analyzed publicly available ACGME Data Resource Book records. Attrition rates and 95% confidence intervals (CIs) were calculated overall and by subspecialty. Logistic regression assessed temporal changes; odds ratios (ORs) compared 2020 to 2007.
Results: From 2007-2020, pediatric residents …