Digital Commons Network^™

Strep Strikes: A Case Of Group A Streptococcal Bacteremia And Second Trimester Pregnancy Loss, Jalen Spain, Racquel Mccrary, Miranda Worley, Rebecca Daugherty

UAB Huntsville Research Day - All Presentations

No abstract provided.

In Through The Side Door: Anti-Asian Nativism, U.S. Immigration, And Foreign Policy—A Legal History And Case Study, Deenesh Sohoni, Vivian E. Hamilton, Chinua Thelwell

Faculty Publications

The 19th- and early 20th-centuries were marked by pervasive anti-Asian sentiment, and antipathy towards people of color more generally. Giving legal effect to the anti-Asian nativism prevalent at the time, U.S. policies prohibited most Asian immigration and naturalization. In particular, immigration laws sought to exclude Asian laborers and working-class immigrants from entry. During the same period, however, the federal government determined that other Asian visitors—especially Chinese government officials, merchants, religious leaders, and students—could be useful in advancing U.S. political and economic interests abroad. Thus, in marked contrast to its inhospitable treatment of their working-class counterparts, U.S. policy facilitated the entry …

Understanding Women's Access To And Utilization Of Syringe Service Programs, Annelisa E. Swiersz

Honors Undergraduate Theses

As of 2020, 138 million Americans ages 12 and over reported illicit drug use in their lifetime, with over 3 million of those people injecting drugs. There are risks for all people who use drugs, but people who inject drugs (PWID) pose specific risks such as hepatitis B, hepatitis C, and human immunodeficiency virus (HIV), with women who inject drugs (WWID) facing even more risks. WWID involved in sex work have a higher risk of HIV transmission and lack access to sterile injection devices and sexual and reproductive health services. To address these risks, syringe service programs (SSPs) were developed …

Tribal Health Self-Determination: The Role Of Tribal Health Systems In Actualizing The Highest Attainable Standard Of Health For American Indians And Alaska Natives, Vanessa Ann Racehorse

Publications

In this Article, I explore the concept of Tribal self-determination in the context of systems that serve American Indian and Alaska Native communities. I investigate the vast health disparities that exist in Tribal communities, as well as the history and current legal framework for the provision of health care in Indian Country. Part of this discussion also provides information on the federal laws and policies that have fractured the traditional lifeways of Native communities and contributed to the disparate health outcomes that now exist. I also provide background on the fundamental federal laws and policies, particularly the Indian Self-Determination and …

A Transformational Agenda For National Security, Maryam Jamshidi

Publications

Past efforts to "reimagine" national security in legal scholarship have largely avoided systematic engagement with the foundational assumptions and presumptions of the field. Challenging and critiquing those assumptions is, however, necessary to producing scholarly work that reimagines, rather than reproduces, status quo approaches to U.S. national security. This Article presents an agenda for reimagining national security through legal scholarship, which is premised on the view that challenging the national security status quo should be part of those efforts. In doing so, this agenda explores seven premises central to how U.S. national security is currently conceived of, practiced, and implemented. Moving …

Displaying Wastewater Surveillance Data: An Ethics Framework, Govind Persad, Anne Barnhill, Douglas Mackay

Publications

No abstract provided.

Poor Cancer Prevention And Detection In Zimbabwe, Kenyon Chipman

Ballard Brief

In the wake of the AIDS/HIV epidemic, rates of non-communicable diseases such as cancer have increased. Although AIDS/HIV and other cancer-associated communicable diseases like HPV are on the decline, these diseases have laid the foundation for the rising cancer epidemic in Sub-Saharan Africa. While infectious diseases remain major contributors to the development of cancer, poor prevention and detection of cancer acts as the central catalyst in the nation’s inflated morbidity and mortality rate. A general lack of knowledge about the basics of cancer for both patients and health professionals, along with the barriers to preventative and detective resources and services, …

Multi-Factor Mathematical Optimization For Healthcare Referral And Facility Placement, Mitchell Moody

Theses

This thesis addresses the challenge of optimizing patient referrals in healthcare systems by integrating clinical needs, geographic proximity, and dynamic infection risk. Healthcare referral networks (HRNs), which capture patient transfers between hospitals, serve as the foundation of the study. First, a recommendation algorithm is developed to assign patients by jointly considering clinical compatibility and logistical considerations like travel distance, striking a balance between quality and accessibility. Building on this, a reinforcement learning framework is proposed to dynamically adjust referral strategies for vulnerable patients by incorporating the evolving risk of hospital-acquired infections. Finally, long-term planning is explored through methods that recommend …

Changing Climate, Changing Health: Perspectives From General Population In Mysuru, Lekhashree A, Manirsha P V, Paranthaman Chinnasamy, Srishti Arya, Sunil Kumar D

Digital Journal of Clinical Medicine

Background: Climate change has emerged as a major public health concern, contributing to rising morbidity and mortality worldwide. In India, increasing heat waves, unpredictable rainfall, and deteriorating air quality have intensified climate-sensitive health conditions. This study aims to assess the health impacts of climate change among the general population of Mysuru.

Methodology: A community-based cross-sectional study was conducted among 400 residents of Mysuru (April–June 2024). Participants were recruited through simple random sampling. Data were collected using a pre-tested semi-structured questionnaire via Google Forms. Analysis was performed using SPSS v26, with descriptive and inferential statistics.

Results: Among 400 participants, …

Use Of Augmented Reality For Mosquito Breeding Sites Identification, Venant Niyonkuru, Sylla Sekou, Jimmy J. Sinzinkayo

Digital Journal of Clinical Medicine

An augmented reality app is used for detecting the possible breeding locations of mosquitoes in different settings precisely. With the aid of the advanced augmented vision technology, the AR system recognizes water-containing containers that are frequent breeding places for mosquitoes according to the visual information obtained through a head-mounted display. It then overlays visual highlights and labels directly onto these containers within the user's field of view, allowing one to instantly identify and spot breeding sites in real time. By combining state-of-the-art AR functionality with powerful computer vision algorithms, the method provides real-time visual feedback for identifying and tagging mosquito …

A Study Of Electrocardiogram And Echocardiography Parameters Of Post Covid – 19 Patients, Venkateswararao K, Durga Prasad Sadhupati

Digital Journal of Clinical Medicine

Background: Coronavirus Disease – 2019 [COVID-19] infection is multisystem disease not restricted to the lungs it has negative impact on Cardiovascular system by activation of ACE-2 receptors causing plaque stability, vascular inflammation and MI. ECG and 2D ECHO is a simple bed side diagnostic test can be used to assess cardiovascular disease involvement in such patients. We aimed to find out ECG and 2D ECHO abnormalities of Covid – 19 patients. To Study relation of SARS-COV-2 infection and Prevalence of Cardiovascular disease.

Methods: We perform Cross Sectional study among 500 Post Covid – 19 patients [>20 and

Results: Out …

Between "Hippies In Suits" And "Money Is The Name Of The Game": Farm Animal Advocates' Analyses Of Political Power In The Farm Bill, Jeff Thomas

Theses and Dissertations

The animal agriculture industry annually slaughters roughly ten billion land animals in the United States. What can be done to improve their welfare and lessen their suffering?

Over the past decade, the problem of farm animal welfare and suffering has drawn increasing interest from the effective altruism community, a loose movement of utilitarian advocates seeking technocratic solutions to social problems (Singer, 2015). As effective altruism has become a more potent driver of the animal welfare movement, an increasing number of nonprofits have begun engaging in political advocacy for farm animal welfare. Facebook co-founder Dustin Moskovitz’ Open Philanthropy is the largest …

Modeling Vaccination Strategies And Intervention Impacts On Infectious Disease Dynamics, Elizabeth B. Amona

Theses and Dissertations

This dissertation explores how mathematical and statistical modeling can inform vaccination strategies and evaluate the impact of interventions during infectious disease outbreaks. Motivated by the challenges observed during the COVID-19 pandemic, the research integrates compartmental modeling, Bayesian inference, and agent-based simulation to assess policy effectiveness and disease control across varying contexts. The first study develops a SEIRDV model that incorporates government interventions and vaccination rollout to examine COVID-19 dynamics in Qatar. A Bayesian approach is used to estimate parameters and compute time-varying transmission rates. The model captures shifts in transmission following policy changes and quantifies the reduction in deaths attributable …

Exploring The Role Of Host Immune Responses And Bacterial Sensory Pathways In The Development Of Treponema Denticola-Mediated Periodontal Disease, Annie N. Hinson

Theses and Dissertations

Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial communities and maladaptive host responses. Treponema denticola, a spirochete pathobiont, is strongly associated with disease severity. However, the molecular mechanisms underlying its interaction with host tissues and regulation of virulence remain incompletely understood. This work examines both the epithelial immune responses and bacterial transduction systems that shape T. denticola pathogenesis. Transcriptomic analysis of gingival keratinocytes revealed IL-36γ as the most highly induced cytokine following infection with T. denticola. Functional studies demonstrated that IL-36γ induction occurs in a dose- and time-dependent manner through TLR2/6 signaling, requiring the NF-κB, PI3K/Akt, and …

Dickkopf1(Dkk1): A Novel Endogenous Ligand To Prime Nlrp3 Inflammasome Via Tlr4, Theingi Aung

Theses and Dissertations

Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1 to activate NFκΒ pathway-mediated gene expression and pyroptosis via NLRP3 inflammasome in human and mouse macrophages.

DKK1 employed TLR4 to initiate NFκB signaling cascade via MyD88. MyD88-TAK1-NFκΒ pathway activation by DKK1 increased HIF1α, NFκB, and NLRP3 protein expression levels, leading to pyroptosis. Unlike LPS, DKK1 did not induce IRAK4 phosphorylation, while the interaction between MyD88 and IRAK4 was maintained for downstream signaling activation. DKK1 did not induce IRF3 phosphorylation …

Public Protest And Civil Unrest, Timothy Zick

Faculty Publications

Governments and officials must respond to protest-related civil unrest. How they do so is both an index of official respect for dissent and a measure of how committed governments are to democratic accountability. This Article examines official responses to civil unrest in connection with several recent high-profile demonstrations. In general, it concludes that governments and officials have relied on aggressive and increasingly draconian measures to quell protest-related civil unrest. Among other things, they have invoked emergency powers and used aggressive protest policing methods; dispatched federal agency personnel and threatened to deploy military forces to police demonstrations; enacted successive waves of …

Bacteria-Engineered Vesicles For Cancer Immunotherapy: From Immunomodulation In Vitro To Anti-Tumor Effects In Melanoma Models, Lan Li

Theses and Dissertations--Chemistry

Bacterial vesicles hold immense potential in various biomedical fields. Among these, outer membrane vesicles (OMVs) produced by Gram-negative bacteria are the most extensively studied. While the exact mechanism of OMV production remains unclear, numerous environmental factors have been shown to influence both their yield and composition. In this study, we investigated the effect of three different antimicrobial families on OMV production by E. coli. Interestingly, antimicrobials within the same family did not provide the same effects on OMV yield, suggesting that OMV production may not directly correlate with the antimicrobial mechanism of action. OMVs have demonstrated tumor-inhibitory activity in multiple …

Ode To An Earthworm, Sarah Chandler

The Art of Medicine

No abstract provided.

Effect Of Universal Health Coverage On Neonatal Mortality Rate In Sub-Saharan Africa: Addressing Missing Data In Health Indicators, Elizabeth Nalule Arihoona

Graduate Research Theses & Dissertations

This study utilizes two mixed-effects models to examine the effect of Universal Health Coverage on Neonatal Mortality Rate (NMR) in 30 countries of Sub-Saharan Africa from 2000-2019 while addressing the missing data in health indicators. Using natural cubic spline interpolation, I impute the missing values in the health coverage indices to preserve the location- specific trends of the data. Findings indicate that among the health Coverage indices, only Index1, which directly relates to coverage of maternal, newborn and child health services is significantly associated with reduced NMR. While higher Current Health Expenditure is associated with reduced NMR, a higher share …

Design, Synthesis, And Evaluation Of Di-Peptide Probes For Stoichiometric Quantitative Analysis Of Antibodies, Taylor Gladson

Graduate Research Theses & Dissertations

Quantitative information on biomarkers is a decisive factor in a wide range of situations concerning individual and public well-being. Under certain circumstances, the availability of accurate quantitative information can even become a matter of life or death. Therefore, the ability to make quantitative measurements in point-of-care (POC), do-it-yourself (DIY), and limited resource settings (LRS) is crucial for diagnostics, disease management, food safety, biomedical research, forensics, and other areas.In the work, we develop a POC/DIY/LRS-compatible platform for unambiguous (yes/no type) quantitative analysis of antibodies. The heart of the approach is negative cooperativity-based target – probe binding. The binding modality yields a …

Morganella Morganii Meningitis In A Neonate: A Case Report, Madelin Vessels Pharmd Candiadate, Cassie Rough Pharmd Candidate, Robyn Schmucker Md, Mph, Norm Fenn Bcps, Bcpps

Parkview Pharmacy Department

Presented at Midyear Clinical Meeting

Objective: To summarize the interventions that took place to add to the limited data that exists in the world surrounding the treatment and outcomes of M. morganii infections.

Key takeaways: 

• M. morganii meningitis is highly rare in neonates
• There are no defined treatment guidelines or outcomes available to date
• Cefepime sufficiently treated M. morganii meningitis, bacteremia, and concurrent E. coli urinary tract infection

Inorganic Arsenite [I-As (Iii)] Represses Human Renal Progenitor Cell Characteristics And Induces Neoplastic-Like Transformation, Md Ehsanul Haque

Theses and Dissertations

Studies on populations exposed to inorganic arsenic (iAs) have shown an association between this particular exposure and the development of chronic kidney disease (CKD) and renal cell carcinoma (RCC). However, there are few studies addressing how acute exposure of the human kidney to iAs might lead to long-term alterations that might lead to CKD or RCC. This study’s hypothesis is that renal exposure to iAs might alter the renal cells responsible for the repair and regeneration of nephrons damaged by iAs exposure or other renal toxicants. The kidney possesses a minority epithelial cell population that co-express PROM1 and CD24 that …

Sharing Your Science: Special 2025 Edition, Wilson Gonzalez-Espada

Faculty Research at Morehead State University

The Sharing your Science stories were completed as part of a 2025 Science Communication Summer Internship (COMM 647), a collaboration between the Kentucky Academy of Science and the Departments of Engineering Sciences and Communication, Media, Art & Design, Morehead State University, KY. This work was made available as an Open Educational Resource thanks to the Faculty Center for Teaching & Learning, the Camden-Carroll Library, and the Office of Research & Sponsored Programs, Morehead State University.

Comparative Bioinformatic Methodologies In Paleogenetic Pathogen Identification In The Casas Grandes, Victoria Lynne Giovannangelo

Graduate Student Theses, Dissertations, & Professional Papers

The application of metagenomic tools to further elucidate ancient DNA (aDNA) holds promise in paleopathology, particularly for inferring disease patterns in ancient populations, especially in those that are understudied. This study conducts a comparative analysis of the efficacy of taxonomic pipelines--Kraken 2, HOPS/MALT, and HAYSTAC--in detecting pathogens within highly degraded aDNA samples extracted from 22 Medio Period Paquimé individuals from the Casas Grandes archaeological site in Northwest Mexico. The taxonomic results from the pipelines are compared with contamination detection program mapDamage, although concerns arose about the latter program’s ability to work with prokaryotes. Additionally, the findings are compared against prior …

Financial Resilience: A Scoping Review, Conceptual Synthesis, And Theoretical Framework, Jing Jian Xiao

Human Development and Family Science Faculty Publications

Purpose: Financial resilience is becoming increasingly important in socioeconomic environments, yet research on the topic remains in its early stages and is subject to debate. This study aims to provide an overview of the existing literature on financial resilience and develop a heuristic map.

Methodology: A four-step scoping review was conducted to extract data on research features, measures, determinants, outcomes, and definitions from 44 empirical studies on financial resilience across five academic databases.

Findings: Most studies have examined financial resilience over the past five years utilizing cross-sectional secondary data from specific countries. The included studies have used various …

Prospective Use Of Detection Dogs As A Screening Tool For Mycoplasma Ovipneumoniae In Bighorn Sheep (Ovis Canadensis), Michele C. Lovara

Electronic Theses and Dissertations

Mycoplasma ovipneumoniae is a bacterium that can spill over from domestic sheep (Ovis aries) to bighorn sheep (Ovis canadensis), with effects in bighorn sheep ranging from low to no lamb recruitment to whole-herd all-age die-offs from resulting pneumonia. Fast and reliable pathogen or disease detection is essential for managing outbreaks in bighorn sheep and emergences in affected populations. Detection dogs are increasingly being enlisted to close gaps and further complement various disease, pathogen and virus research and response efforts. This thesis explores the use of conservation detection dogs as a potential tool for M. ovipneumoniae surveillance in bighorn sheep through …

Investigating The Ruminal Metagenome Of Grass And Forage-Fed Bison To Uncover Metabolic Activities That Impact The Efficiency Of Plant Fiber Utilization, Anlly Fresno Rueda

Electronic Theses and Dissertations

This dissertation investigates the ruminal microbiome of American plains bison (Bison bison) to uncover the metabolic activities that enable efficient utilization of plant fiber, with a particular focus on bacterial composition and functional capabilities in response to forage quality. Using both 16S rRNA gene sequencing and metagenomic approaches, this research provides a comprehensive view of microbial diversity and metabolic potential in the rumen of bison, offering insights into their ecological resilience and efficiency in nutrient extraction. Chapter 2 focuses on the metabolic potential of bacterial communities in the rumen of bison fed a grass-based diet. Using high-throughput sequencing and metagenomic …

Rbd Amplicon Sequencing And Evolutionary Analysis Of Sars-Cov-2 Variants From Wastewater Samples, Xingwen Chen, Chunfu Zheng, Fuqing Wu

Faculty, Staff and Student Publications

The surveillance of SARS-CoV-2 is significantly limited by the presence of numerous variants with distinct behaviors driven by rapid evolution. Although the conventional clinical genome sequencing method provides comprehensive data, it has limitations in capturing the epidemiological dynamics of the variants circulating in the community. In this chapter, we describe a protocol using RBD amplicon sequencing of wastewater samples. We present the detailed experimental procedure for wastewater sample processing, robust nested-PCR-based amplification of the target RBD sequence, and library preparation. Moreover, we describe a general pipeline of sequencing data processing and interpretation, showing the epidemiological and evolutionary trends of SARS-CoV-2 …

Phenotypic Variation In Disease Severity Among Hospitalized Pediatric Patients With Covid-19: Assessing The Impact Of Covid-19 In The Epico Study, María Camila Sossa-Alarcón, Mónica Paola Gutiérrez, Natalia Becerra, Luz Yessenia Ortegon, María Camila David, Melisa Naranjo Vanegas, Gabriela Friedrich, Pablo Vásquez-Hoyos, María Lucía Mesa-Rubio, Luis Miguel Navarro-Ramirez, Sergio Moreno-Lopez, Olga Lucía Baquero, Luz Marina Mejía, Juan Gabriel Piñeros, Sonia Restrepo-Gualteros, Carlos Álvarez-Moreno, Alejandro Díaz-Díaz, Iván Gutierrez-Tobar, Andrés Camilo Mesa, William Ricardo Bachiller Tuta, Clara Esperanza Galvis Diaz, Martha Africano, José Manuel Nieto, Paola Marsela Pérez Camacho, Claudia Beltrán-Arroyave, Rosalba Vivas Trochez, Irati Gastesi, Cinta Moraleda, Alfredo Tagarro García, Blanca Herrero, Lourdes Calleja, Carlos Grasa, Paula Rodriguez, Susana Melendo, Antoni Soriano-Arandes, Irene Gómez Pastrana, Sonsoles García García, Victoria Fumado, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Objective: To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.

Methods: We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.

Results: A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, …

Long Covid Risk Factors And Outcomes Among Solid Organ Transplant Recipients: A Retrospective Cohort Study, Micaela N Sandoval, Linda W Moore, Howard J Huang, Edward A Graviss

Faculty, Staff and Student Publications

Background: Solid organ transplant (SOT) recipients are not only at increased risk of morbidity and mortality due to acute COVID-19 but may also experience poor long-term outcomes due to post-acute COVID-19 syndromes, including long COVID.

Methods: This retrospective, registry-based chart review evaluated graft failure and mortality among SOT recipients diagnosed with COVID-19 at a large, urban transplant center in Houston, Texas, USA. Patient populations were analyzed separately according to their long COVID status at the time of transplant to preserve the temporal relationship between the exposure (long COVID) and the outcome (graft failure or mortality).

Results: In total, 146 (5%, …