Digital Commons Network^™

Best Kept Secret: The Hidden Health Costs Of Corporate Confidentiality, Cynthia M. Ho

Faculty Publications & Other Works

Although patents are well known to negatively impact health when drugs are unaffordable, trade secrets also harm health, and in more ways than patents. Patented drugs harm public health simply by temporarily increasing prices on treatments. Trade secrets, on the other hand, can not only increase treatment costs, but also hide knowledge needed for effective medical treatment. Also, because patents, but not trade secrets, have a limited term, patent health harms clearly terminate while trade secret harms do not. Moreover, the public may not even be fully aware of all trade secret health harms because trade secret information is, by …

Biol 606-102: Applied Bioprocessing & Immunology Based Therapies, John Yarotsky

Biology Syllabi

No abstract provided.

Development Of An Educational Toolkit For Washington State Nursing Professionals Regarding Climate-Related Impacts On Health, Margaret "Maggie" Pinson

DNP Scholarly Projects

BACKGROUND: Most healthcare professionals (HCPs) know that climate change poses a serious threat to human health, but few physicians and nurses actually discuss climate-related impacts on health with their patients. This knowledge-practice gap poses a risk to patient safety.

PROBLEM: Patients who are unaware of environmental threats to health may develop new illnesses, experience unnecessary exacerbations of underlying health problems and may die.

METHODS: A quality improvement intervention that addressed the educational needs of HCPs as described in the literature was developed and hosted on an online survey platform.

INTERVENTION: Preintervention survey questions captured baseline attitudes, beliefs, and knowledge. The …

Exploring The Journey To Heart Failure Diagnosis In Uganda, Teimur Kayani

Yale Medicine Thesis Digital Library

This study sought to explore the healthcare journeys of patients recently diagnosed with heart failure (HF) in Uganda. Using a semi-structured guide developed in collaboration with Ugandan colleagues, we conducted in-depth interviews with 19 patients diagnosed with HF within the past three months across four regional referral hospitals in Uganda. Interviews were conducted in the participant’s preferred language (English, Luganda, Lugbara, Lugisu, or Swahili) using trained research assistants (RAs) and were recorded, transcribed verbatim, and thematically analyzed using the socioecological framework (SEM) to capture individual, interpersonal, community, and systemic-level barriers to HF care.Findings revealed a total of 11 themes spread …

Cutaneous Fungal Infections In The United States: A Cross-Sectional Analysis Of National Surveys, Sarah Lee Spaulding

Yale Medicine Thesis Digital Library

Superficial cutaneous fungal infections (SCFIs), caused by yeasts, dermatophytes, and nondermatophyte molds, are prevalent skin conditions with substantial economic and quality-of-life implications. This study aimed to evaluate trends in the prevalence of SCFIs in the United States between 2005 and 2016, using data from the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS).We performed a cross-sectional analysis of outpatient visits with SCFIs diagnoses, identified through the International Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification (ICD-9-CM and ICD-10-CM). Diagnoses included conditions such as tinea unguium, tinea pedis, and candidiasis of the skin …

Improvement Of Hpv Vaccination Rate In Pediatric Patients In A Clinic Through Implementation Of A Bundle, Macalah Jenschke

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Introduction: Human papillomavirus (HPV) is a major cause of several cancers, and vaccination is a highly effective preventive measure. However, HPV vaccination rates remain suboptimal, particularly in rural pediatric populations. This quality improvement (QI) project aims to enhance HPV vaccination rates through the implementation of a comprehensive vaccination bundle targeting provider education, patient and parent education, appointment reminders, and the use of a vaccine waiver when needed.

Method: This QI project was conducted over twelve weeks in a rural pediatric clinic with approximately 130 patients seen daily. The intervention bundle included provider education on effective communication regarding HPV vaccination, educational …

Anxiolytic Intervention: Modulation Of Cell Types Due To Nicotine Withdrawal, Taylor Elder

Theses and Dissertations--Pharmacy

Nicotine use disorder (NUD) remains a leading cause of preventable disease, yet the neurobiological mechanisms underlying nicotine withdrawal are incompletely understood. Emerging evidence implicates neuroimmune signaling and astrocytic regulation of glutamate in shaping the withdrawal-associated affective phenotype. This dissertation investigated these processes using multiple nicotine administration paradigms including osmotic minipump implant, cigarette smoke exposure, and nicotine vapor inhalation to model diverse routes of human nicotine intake.

Chapter 2 examines the effects of these three modes of administration on neuroinflammation and validation of nicotine delivery. Nicotine exposure was confirmed through receptor [³H]Epibatidine nAChR binding assay and serum cotinine measurements. …

The Impact Of Maternal Environmental Exposures On The Immune Landscape Of The Maternal-Fetal Interface, Heather E. True

Theses and Dissertations--Pharmacy

Maternal environmental exposures and inflammation are known to impact fetal development in utero as well as increase the risk for chronic diseases later in life. Therefore, it is essential that we understand how the maternal environment alters placental structure and immune function.

Therefore, we isolated fetal (chorionic villous) tissues from the placentas of healthy pregnant participants (control) and those with inflammatory conditions, including SARS-COV-2 infection, pregravid obesity, and opioid use disorder. Isolated placental leukocytes were subjected to a series of assays to uncover the phenotypic, functional, and transcriptional (single-cell RNA-sequencing) landscape of placental immune cells. Additional placental tissues were subjected …

Simplified Molecular Diagnostics Methods For Environmental Testing Of Pathogens And Other Applications, Mohammad Dehghan Banadaki

Theses and Dissertations--Mechanical and Aerospace Engineering

Environmental Surveillance (ES) has emerged as a powerful tool to monitor the emergence and persistence of a pathogen within a facility or community using wastewater/water analysis. Over the past four years, implementation of ES has experienced an explosive acceleration, driven by efforts to monitor the spread of SARS-CoV-2, which has made ES a routinely used public health tool in many locations. We can now use ES to measure the emergence/presence/abundance of different viruses (e.g., SARS-CoV-2, influenza, mpox), bacteria (e.g., E. coli, V. cholerae, antibiotic-resistant strains), fungi (e.g., C. auris), and other biological markers indicative of infectious diseases. However, its broad …

Engineering Novel Biomimetic Models Of Equine Host-Microbe Interactions, Lynn M. Leedhanachoke

Theses and Dissertations--Veterinary Science

One major limitation to the study of equine disease is the lack of in vitro models that accurately reflect the dynamic physiology of the horse. Thus, there is a pressing need to develop in vitro systems that recapitulate diverse equine tissue and organ microenvironments. To overcome this deficiency, we developed multiple biomimetic equine organoid systems that can be employed for a variety of investigations aimed at resolving outstanding questions in infectious disease pathogenesis, therapeutic development and drug metabolism, host defense mechanisms, immune-modulated disease, and equine developmental biology. Our innovative platform incorporates novel equine intestinal enteroid and airway organoid models derived …

Legacy Of Buck V. Bell: Women’S Bodies As Border Wall, Georgia Macedo Cardoso

Student Works

No abstract provided.

Cyclical Health Disparities And The Future Of The Indian Health Service, Emily York

Student Works

No abstract provided.

Genomic Consequences Of Habitat Fragmentation In The Florida Scrub-Jay: Diversity, Adaptation, And Disease Susceptibility, Maryam Ghoojaei

Graduate Thesis and Dissertation post-2024

Habitat fragmentation is a severe threat to biodiversity by reducing population size, gene flow, and adaptive potential, especially in habitat specialists like the Florida Scrub-Jay (Aphelocoma coerulescens). This dissertation integrates whole-genome sequencing and immunogenetics to assess the genomic consequences of habitat fragmentation across three primary Florida Scrub-Jay strongholds: Archbold Biological Station, Ocala National Forest, and Florida’s East Coast. In Chapter 2, I focused on adaptive genetic diversity at the Major Histocompatibility Complex (MHC) class II genes. I characterized MHC allelic richness, evaluated signatures of selection, and examined associations with pathogen infections. Despite population declines, I found moderate MHC diversity, suggesting …

Contagion Chronicles: A Spatiotemporal Analysis Of Armed Conflict And Infectious Disease, Devyn Escalanti

Graduate Thesis and Dissertation post-2024

This dissertation examines the relationship between armed conflict and infectious disease transmission through a novel theoretical framework that integrates ecological disturbance and health systems resilience theories into epidemiological contexts. The framework conceptualizes diseases along a continuum from "pulse" to "press." Pulse diseases, like Ebola, are characterized by sudden onset, high mortality, and short-term outbreaks. Press diseases, like HIV, progress gradually with lower mortality and long-term persistence. Grounded in this pulse–press disease typology and ecological and health systems resilience, the theory suggests that the absorptive capacity, adaptive capacity, and resilience of community health workers in conflict areas can influence disease transmission, …

Exploring The Experience Of Heart Disease Among Burmese Immigrants In The United States, Khup S. It

Graduate Thesis and Dissertation post-2024

The ongoing political and military turmoil in Myanmar has resulted in a significant increase in the migration of Burmese individuals to the United States in recent years. This demographic shift has brought attention to the health challenges faced by Burmese immigrants, particularly with regard to heart disease (heart attack). The complexities of the U.S. healthcare system, compounded by legal and social barriers, place immigrants at greater risk for health disparities. This study examines the health challenges of Burmese immigrants in Tulsa, Oklahoma, with a specific focus on their perceptions and experiences related to heart disease, as explored through illness narratives. …

Analisis Situasi Masalah Penyakit Infeksi Menular Seksual Di Kota Bogor Tahun 2024, Wardiman Wardiman, Ratna Djuwita, Bai Kusnadi

Jurnal Epidemiologi Kesehatan Indonesia

Abstrak

Infeksi menular seksual (IMS) masih menjadi tantangan kesehatan global, termasuk di Indonesia, terutama pada kelompok usia produktif 15-49 tahun. Di Kota Bogor, angka kasus IMS mengalami peningkatan, namum belum sepenuhnya menggambarkan kondisi yang sebenarnya. Penelitian ini bertujuan untuk menganalisis situasi IMS secara mendalam dan menetapkan prioritas masalah kesehatan menggunakan metode PAHO-adapted Hanlon, yang mengacu pada pembobotan Basic Priority Rating (BPR) berdasarkan lima kriteria utama, yaitu, A=Masalah utama; B=Keseriusan masalah; C=Efektivitas intervensi; E=Ketidakadilan; F=Kapasitas institusi dalam mengatasi masalah. Penelitian ini dilaksanakan di Dinas kesehatan Kota Bogor pada Oktober 2024 hingga Januari 2025, dengan pendekatan kualitatif dan kuantitatif, serta disajikan secara …

Gambaran Putus Obat Berdasarkan Sosial-Demografi Pada Penderita Tuberkulosis Di Indonesia Tahun 2023: Cross-Sectional Study, Anindya Oktaria Yudhanti, Arina Syahida Hurva Radisan Saf, Benita Riska, Enita Fransiska Tamba

Jurnal Epidemiologi Kesehatan Indonesia

Introduction: Tuberculosis is an infectious disease that spreads through the air. Based on data at the international and national levels, there has been an increase. Most pulmonary TB patients are cured with consecutive antibiotic treatment for 6-9 months, but there are still patients who eventually drop out of treatment. This could be a challenge in achieving the international tuberculosis elimination target of 2035 and the national target of 2030. Methods: This study analyzed the socio-demographic distribution and dropout analysis of Tuberculosis patients in Indonesia in 2023 based on SKI data with a cross-sectional study type. Results: The incidence of drug …

Gambaran Kasus Gondongan Pada Sekolah Dasar Negeri 010 Makroman, Samarinda, Dwi Listiani, Ashri Budi Astuti, Jami'an Jami'an, Eko Prasetya Budi, Arif Sumarianto, Irfansyah Baharuddin Pakki

Jurnal Epidemiologi Kesehatan Indonesia

Mumps is an infectious disease caused by a viral infection, often attacking the salivary glands, especially the parotid glands. This disease is self-limiting and common in elementary school children. This study aims to describe the prevalence, symptoms, and impact of mumps in students of SD Negeri 010 Makroman, Samarinda, as well as evaluate risk factors and relevant prevention efforts. With a descriptive research design, data was obtained from a population of 307 students through secondary data from the Makroman Health Center and direct on-site investigations. An attack rate of 3.58% indicates a limited impact on at-risk populations, but it is …

Cultural Competency Of The Interprofessional Team In Burn Care Through An Occupational Therapy Model, Brooklyn Wiest

Occupational Therapy Capstones

Purpose: Burn injuries are considered one of the most devastating injuries globally (Farzan et al., 2023). Those suffering from serious burns are likely to be affected in all areas of life (physical, social, mental, emotional, spiritual, environmental, intellectual, and psychological) (Abrams et al., 2016). Some of these impacts include changes in appearance, social isolation, stress, anxiety, depression, self-esteem, employment, financial burden, and family problems. These are devastating outcomes are seen throughout diverse populations (Nair & Adetayo, 2019). As diverse populations are rising, an increase in equitable medical care is needed (Peters et al., 2022). Education and increasing awareness of culturally …

Addressing Delirium In The Intensive Care Unit: An Interprofessional Approach, Olivia Grace O'Neill

Occupational Therapy Capstones

Purpose: Successful recovery from an intensive care stay is influenced by many factors, including length of stay, medical ventilation requirements, and the extent of surgical interventions such as cardiac, intracranial surgery, neurosurgery, and vascular neurosurgery. A major barrier to achieving a full recovery can be delirium, which is seen in 80% of critical care patients. Delirium is described as a severe change in mental abilities and a short-term cause of cerebral impairment that can present as distortion or psychosis and is associated with numerous conditions. While critical care-related delirium typically lasts less than a week, those affected by longer periods …

Physical Ablative Methods And Cancer Cell Death: Implications For Immunity And Therapies, Alessandra Rossi, Claudia Muratori

Bioelectrics Publications

Surgery has traditionally been a cornerstone in cancer treatment, yet its feasibility can be limited by factors such as tumor location and patient health conditions. When surgery is not viable, thermal and pulsed electric field (PEF)-based ablation technologies offer valuable alternatives. Emerging evidence suggests that these approaches not only target tumors effectively but also stimulate antitumor immune responses. In this review, we begin by examining the distinctive features of hyperthermic treatments (radiofrequency and microwave ablation), cryoablation, and PEF-technologies. Subsequently, we discuss the mechanisms of cell death, stress responses, and release of danger signals triggered by these diverse ablation technologies. Finally, …

Stress Affects Infectious Disease Outcomes In Canaries, Vansh Singhal, Erin Sauer, Salvador Barraza-Del Barco, Kamiah H. Turner, William H. Kirkpatrick, Weston Perrine, Sarah Heissenberger, Sarah E. Durant

2025 Research Poster Competition

Chronic stress is related to a decline in immune function in all living organisms and is known to increase the likelihood of developing or exacerbating chronic non-infectious diseases. However, the role of chronic stress in affecting outcomes of infection important to individual health and endpoints important for epidemic dynamics (e.g., likelihood of transmission) are not well understood. In this study we exposed canaries (Serinus canaria) to chronic stress or control conditions after which they were inoculated with Mycoplasma Gallisepticum, a bacterium that causes respiratory disease in birds.

Following the chronic stress protocol, the canaries were assessed every day for measures …

Nomad: Metagenomic Characterisation Of The Viral Pathogen Composition In Outbreaks Of Non-Malaria Acute Febrile Illness Cases, Benard W. Kulohoma, Ibrahim Ng'eno

All Peer-Reviewed Publications

The clinical importance of non-malaria febrile acute illness (NM-AFI) in patients with a negative parasitological test has become apparent, with the progressive reduction in malaria transmission in endemic regions. Bacterial pathogens, for example Streptococcus pneumoniae and Haemophilus influenzae, which contribute disproportionally to febrile illness, are now preventable by vaccines. However, there are no vaccines, and little is known about viral NM-AFI prevalence, proliferation, virulence, and transmission chains between hosts. Although the predominant viral causes of NM-AFI are established, it is unclear if there are other NM-AFI associated emerging infectious viral pathogens that previously remained undetectable by conventional diagnostic strategies, for …

Flavorful Foes: Assessing Students’ Perceptions Of Processed And Fast Food And Its Health Implications., Soumi Roy Banerjee

Theses and Dissertations

High fast-food consumption is a common public health concern due to its link to a number of non-communicable diseases and mental health, but increased consumption of processed food, rapid urbanization, and changing lifestyles have led to a shift in dietary patterns. People are consuming more foods high in energy fats and free sugars. This mixed methods study was conducted at a college campus in Georgia, to assess knowledge and understanding of the students between the ages of 18 and 22 years about highly processed Fast Food, and its effects on health. Forty student participants were chosen through convenience sampling and …

“What We Say Matters”: Reducing Drug Use Stigmatization By Healthcare Professionals Through A Narrative-Based Awareness Campaign, Adam M. Traugott

DNP Projects

Background: Stigma towards substance use has been identified as a contributor to poor care and health outcomes amongst people who use drugs (PWUD), a vulnerable population. Healthcare worker stigma negatively affects the outcomes of individual patients and may have greater public health implications. Methods of addressing drug-use stigma have previously been implemented in a variety of clinical settings. Presenting the lived experience of PWUD to healthcare workers via emotionally compelling narratives has been found to be an effective means of stigma reduction.

Purpose: This study utilized two psychometrically validated tools to measure (1) the baseline prevalence of drug use stigma …

Culture-Free Whole Genome Sequencing Of Mycobacterium Tuberculosis From Clinical Specimens, Chaney Christine Kalinich

Yale Medicine Thesis Digital Library

Tuberculosis (TB) is a leading cause of infection-related mortality worldwide, causing an estimated 1.13 million deaths in 2022. The majority of infections can be successfully treated with antibiotics, but the prevalence of drug-resistant TB and a lack of rapid and cost-effective drug susceptibility tests for many key antibiotics is a significant barrier to treatment. Whole-genome sequencing of Mycobacterium tuberculosis can be used for drug susceptibility testing and can provide valuable insight into transmission patterns. However, M. tuberculosis is slow to grow, meaning traditional sequencing methods which require culture can take many weeks to return results, greatly limiting the potential clinical …

Polymeric Nanocomposites-Based Advanced Coatings For Antimicrobial And Antiviral Applications: A Comprehensive Overview, Rachid Amrhar, Jaspal Singh, Mostafa Eesaee, Pascal Carrière, Alireza Saidi, Phuong Nguyen-Tri

Revues de littérature, synthèses de connaissances

The rise in microbial infections and viral outbreaks has accelerated the development of advanced antibacterial and antiviral coating that effectively minimize infection risks. Amidst rising global health concerns due to infectious diseases, these coatings have emerged as vital solutions for surface protection across various settings. This review focuses on the recent development and in-depth analysis includes synthesis process, inactivation mechanism in photoreactive antimicrobial and antiviral bio-coatings. This review comprehensively explores the development of different nanocomposite materials, including polymers based on metal oxide nanoparticles, metal nanoparticles, graphene-based materials, and organic-inorganic composites. Their practicality and compatibility with diverse surfaces such as ceramics, …

Popular Sovereignty And A Right To Know About The Government, David S. Ardia

Faculty Publications

This Article argues that the U.S. Constitution implicitly contains a structural “right to know” about the government, rooted in the doctrine of popular sovereignty rather than the First Amendment. Democratic self‑government requires public access to governmental information; without it, the people cannot exercise informed consent or their sovereign authority. The Article critiques reliance on purely statutory transparency regimes such as FOIA, noting their fragility and susceptibility to political rollback. Through historical and structural analysis, it shows that the Framers viewed an informed citizenry as essential to maintaining checks and balances. The Article proposes three principles for operationalizing a constitutional right …

Yale Medicine Magazine December 2025, Issue 175, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the December 2025 issue of Yale Medicine Magazine, issue 175. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).

Political Disinformation In The Anthropocene, Jeffrey Omari

Washington and Lee Law Review

The Anthropocene is the name that scientists have given to our current geological epoch, which references the overwhelming influence of human agency on the Earth and its ecological systems. Adopted as a theoretical tool across multiple academic disciplines, social scientists often employ the term to address deep-rooted political and socioeconomic problems and the symptoms of global inequalities and injustices. Meanwhile, legal scholars have employed the term to address the global environmental harms of human agency and to examine how normative frameworks must fundamentally change and adapt to the times ahead. At the same time, recent scholarship also notes that democracies …