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Faculty Senate Meeting Agenda And Minutes, March 17, 2025

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on, March 17, 2025.

Phase I Trial Of Tti-101, A First-In-Class Oral Inhibitor Of Stat3, In Patients With Advanced Solid Tumors, Apostolia M Tsimberidou, David J Vining, Sukeshi P Arora, Sofia De Achaval, Jeffrey Larson, John Kauh, Carrie Cartwright, Rony Avritscher, Imran Alibhai, David J Tweardy, Ahmed O Kaseb

Faculty, Staff and Student Publications

Purpose: Signal transducer and activator of transcription 3 is a transcription factor that is essential for the survival and immune sequestration of cancer cells. We conducted a phase I study of TTI-101, a first-in-class, selective small-molecule inhibitor of signal transducer and activator of transcription 3, in patients with advanced metastatic cancer.

Patients and methods: Patients were treated with TTI-101 orally twice daily in 28-day cycles at four dose levels (DL): 3.2 (DL1), 6.4 (DL2), 12.8 (DL3), and 25.6 (DL4) mg/kg/day ("3+3" design). Three TTI-101 formulations were used in a stepwise manner (NCT03195699).

Results: Sixty-four patients were treated (median …

Intouch Week Of March 17, 2025, New York Medical College

InTouch

• SOM Continues Tradition of Distinction with 2025 Alpha Omega Alpha Induction
• Focused Ultrasound's Promise for Neurological Disorders
• A Clinical Experience Abroad

Correction: Ellsworth, M.; Ostrosky-Zeichner, L. Isavuconazole: Mechanism Of Action, Clinical Efficacy, And Resistance, Misti Ellsworth, Luis Ostrosky-Zeichner

Faculty, Staff and Student Publications

In the original article [1], in Section 6.3, “Treatment groups received caspofungin 750 mg IV on day 1” should be “70 mg” instead of “750 mg”. We made a mistake in the process of writing. The corrected paragraph is as follows:

“Treatment groups received caspofungin 70 mg IV on day 1 followed by 50 mg IV daily or 200 mg of isavuconazole IV q8h on days 1–2 followed by 200 mg once daily.”

The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Association Of Messenger Rna Coronavirus Disease 2019 (Covid-19) Vaccination And Reductions In Post Covid Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection In A Us Prospective Cohort Of Essential Workers, Josephine Mak, Sana Khan, Amadea Britton, Spencer Rose, Lisa Gwynn, Katherine D Ellingson, Jennifer Meece, Leora R Feldstein, Harmony Tyner, Laura J Edwards, Matthew S Thiese, Allison Naleway, Manjusha Gaglani, Natasha Solle, Jefferey L Burgess, Julie Mayo Lamberte, Meghan Shea, Taryn Hunt-Smith, Alberto Caban-Martinez, Cynthia Porter, Ryan Wiegand, Ramona Rai, Kurt T Hegmann, James Hollister, Ashley Fowlkes, Meredith Wesley, Andrew L Philips, Patrick Rivers, Robin Bloodworth, Gabriella Newes-Adeyi, Lauren E W Olsho, Sarang K Yoon, Sharon Saydah, Karen Lutrick

Center for Medical Ethics and Health Policy Staff Publications

Background: Data are limited on whether vaccination reduces post COVID conditions (PCCs) risk after less severe nonhospitalized coronavirus disease 2019 (COVID-19). This study assessed whether COVID-19 vaccination protected against PCCs in persons with mild initial infections during Delta and Omicron variant predominance.

Methods: This study utilized a case-control design, nested within the HEROES-RECOVER cohort. Participants aged ≥18 years with test-confirmed severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) between 28 June 2021 and 14 September 2022 were surveyed for PCCs, defined by symptoms lasting >4 weeks after initial infection. Cases self-reported PCCs and controls self-reported no PCCs. The exposure was …

Genetic Associations With C-Peptide Levels Before Type 1 Diabetes Diagnosis In At-Risk Relatives, Taylor M Triolo, Hemang M Parikh, Mustafa Tosur, Lauric A Ferrat, Lu You, Peter A Gottlieb, Richard A Oram, Suna Onengut-Gumuscu, Jeffrey P Krischer, Stephen S Rich, Andrea K Steck, Maria J Redondo

Children’s Nutrition Research Center Staff Publications

Objective: We sought to determine whether the type 1 diabetes genetic risk score-2 (T1D-GRS2) and single nucleotide polymorphisms are associated with C-peptide preservation before type 1 diabetes diagnosis.

Methods: We conducted a retrospective analysis of 713 autoantibody-positive participants who developed type 1 diabetes in the TrialNet Pathway to Prevention Study who had T1DExomeChip data. We evaluated the relationships of 16 known single nucleotide polymorphisms and T1D-GRS2 with area under the curve (AUC) C-peptide levels during oral glucose tolerance tests conducted in the 9 months before diagnosis.

Results: Higher T1D-GRS2 was associated with lower C-peptide AUC in the 9 months before …

Dengue Cases In Hanoi, Vietnam: Unseasonal Surge Foreshadows Increased Incidence That Demands Organized Preventive Action, Andrew W. Taylor-Robinson

Chulalongkorn Medical Journal

Letter to the Editor - Abstract not required.

Cracking The Code Of Hbv Persistence: Cutting-Edge Approaches To Targeting Cccdna In Chronic Hepatitis B With Or Without Pyogenic Liver Abscesses, Umar Saeed, Zahra Zahid Piracha, Mahmood Khan, Muhammad Nouman Tariq, Syed Shahan Gilani, Muhammad Raza, Rakshana Munuswamy, Naveen Bose, Dilber Uzun Ozsahin, Ilker Özşahin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Chronic Hepatitis B Virus (HBV) infection remains a formidable global health challenge, driving severe liver complications such as hepatocellular carcinoma (HCC) and pyogenic liver abscesses (PLA). At the core of HBV persistence lies covalently closed circular DNA (cccDNA), a viral reservoir that fuels ongoing infection despite antiviral treatments. This review highlights molecular mechanisms governing cccDNA formation, maintenance, and clearance, spotlighting innovative therapeutic strategies to disrupt this key viral element. We explore cutting-edge approaches, including epigenetic modulation to silence cccDNA, RNA interference (RNAi) for viral RNA degradation, and CRISPR/Cas genome editing to excise cccDNA directly. Additionally, emerging antiviral therapies and immunotherapies, …

Assessing Coronavirus Disease 2019 Pandemic Impacts On The Health Of People Who Inject Drugs Using A Novel Data Sharing Model, Heather Bradley, Nicole Luisi, Anastasia Carter, Terri D. Pigott, Daniela Abramovitz, Sean T. Allen, Alice Asher, Chelsea Austin, Tyler S. Bartholomew, Marianna Baum, Amy Board, Basmattee Boodram, Annick Borquez, Kathryn A. Brookmeyer, Kate Buchacz, Janet Burnett, Hannah L.F. Cooper, Nicole Crepaz, Kora Debeck, Judith Feinberg, Chunki Fong, Edward Freeman, Nathan Woo Furukawa, Becky Genberg, Pamina Gorbach, Holly Hagan, Kanna Hayashi, Emalie Huriaux

Epidemiology and Environmental Health Faculty Publications

Objective: Using an innovative data sharing model, we assessed the impacts of the COVID-19 pandemic on the health of people who inject drugs (PWID). Design: The PWID Data Collaborative was established in 2021 to promote data sharing across PWID studies in North America. Contributing studies submitted aggregate data on 23 standardized indicators during four time periods: prepandemic (March 2019 to February 2020), early-pandemic (March 2020 to February 2021), mid-pandemic (March 2021 to February 2022), and late pandemic (March 2022 to February 2023). Methods: We present study-specific and meta-analyzed estimates for the percentage of PWID who took medications for opioid use …

From Pregnancy To Beyond: Renewed Emphasis On Comprehensive Hiv Prevention In South Africa., Chibuzor M. Babalola, Remco P.H. Peters, Christina A. Muzny, Dvora Joseph Davey, Christopher M. Taylor, Mandisa M. Mdingi, Freedom Mukomana, Lindsey De Vos, Andrew Medina-Marino, Jeffrey D. Klausner

School of Medicine Faculty Publications

No abstract provided.

Inflammation And Gut Barrier Function-Related Genes And Colorectal Cancer Risk In Western European Populations, Hannah B Mandle, Mazda Jenab, Marc J Gunter, Anne Tjønneland, Anja Olsen, Christina C Dahm, Jie Zhang, Pierre-Emmanuel Sugier, Joseph Rothwell, Gianluca Severi, Rudolf Kaaks, Verena A Katzke, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Catalina Bonet, Maria-Jose Sánchez, Pilar Amiano, José María Huerta, Marcela Guevara, Richard Palmqvist, Thyra Löwenmark, Aurora Perez-Cornago, Elisabete Weiderpass, Alicia K Heath, Amanda J Cross, Paolo Vineis, David J Hughes, Veronika Fedirko

Faculty, Staff and Student Publications

Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn's disease with colon and rectal cancer risks. Incident CRC cases (N = 1374; colon = 871, rectum = 503) were matched 1:1 to controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. Previously measured serum concentrations of gut barrier function and inflammation biomarkers (flagellin/LPS-specific immunoglobulins and C-reactive protein [CRP]) were available for a sub-set …

The Extent Of Achieving Life Satisfaction For Families Of Children With Multiple Disabilities In Tubas Governorate In Light Of Some Variables, Atef Sabri Awad

Alustath Journal for Human and Social Sciences

This study aimed to identify (The extent to which life satisfaction is achieved for families of children with multiple disabilities in Tubas Governorate in light of some variables), and after enumerating the study population, the researcher selected the study sample by a simple random method, and it consisted of (50) families who have children with multiple disabilities in Tubas Governorate. The researcher also prepared the study tool (the questionnaire), and then verified it by reviewing it linguistically, and presenting it to a group of reviewers specialized in this field at Al-Quds Open University, in order to ensure its validity, …

Exploring The Mechanistic Interplay Between Chronic Inflammation And Gastrointestinal Cancer In The Gut Microbiome: A Review, Hanan Mohamed Abd Elmoneim

Saudi Toxicology Journal

There are complex and heterogeneous immunological milieus of the gastrointestinal system, so there is a high mortality rate from malignancies affecting the gastrointestinal system. The pathophysiology of cancer has long been thought to be significantly influenced by inflammation. However, several of the mechanisms underlying its tumor-promoting activities have only lately been discovered. Both beneficial and harmful microorganisms play a crucial role in controlling the host immune system and, eventually, inflammation. Furthermore, bacteria may also influence how a tumor develops through different mechanisms, including long-term inflammation activation, changes to the tumor microenvironment, and genotoxic response induction. A significant percentage of cancers …

“Smart Trap”: A Portable Device For Real-Time Mosquito Capturing And Classification Using Image-Based Analysis, Fahim Rahman

USF Tampa Graduate Theses and Dissertations

Capturing mosquitoes in real-time and taking high-quality images for classification with state-of-the-art methods is not only time-consuming but also expensive. Sometimes even carefully controlled environments and experimental setups fail to capture living mosquitoes. Catching live mosquitoes is necessary to be able to study aspects of their physiology and behavior that cannot be investigated by collections of resting mosquitoes and dead specimens, and to help estimate the local population numbers. My thesis introduces a “Smart Trap”, a small portable device that can attract mosquitoes in real-time, capture them, take high-quality images with dual cameras, and store those images in the cloud. …

Precision Phenotyping For Curating Research Cohorts Of Patients With Unexplained Post-Acute Sequelae Of Covid-19, Alaleh Azhir, Jonas Hügel, Jiazi Tian, Jingya Cheng, Ingrid V Bassett, Douglas S Bell, Elmer V Bernstam, Maha R Farhat, Darren W Henderson, Emily S Lau, Michele Morris, Yevgeniy R Semenov, Virginia A Triant, Shyam Visweswaran, Zachary H Strasser, Jeffrey G Klann, Shawn N Murphy, Hossein Estiri

Faculty, Staff and Student Publications

BACKGROUND: Scalable identification of patients with post-acute sequelae of COVID-19 (PASC) is challenging due to a lack of reproducible precision phenotyping algorithms, which has led to suboptimal accuracy, demographic biases, and underestimation of the PASC.

METHODS: In a retrospective case-control study, we developed a precision phenotyping algorithm for identifying cohorts of patients with PASC. We used longitudinal electronic health records data from over 295,000 patients from 14 hospitals and 20 community health centers in Massachusetts. The algorithm employs an attention mechanism to simultaneously exclude sequelae that prior conditions can explain and include infection-associated chronic conditions. We performed independent chart reviews …

Exploring Health Equity With Culturally Specific Providers Of Permanent Supportive Housing, Judith Solomon

University Honors Theses

Chronic homelessness is an important public health issue. Permanent Supportive Housing (PSH) is a promising opportunity for transitioning people experiencing homelessness into housing, however there remain unaddressed racial inequities in service provision and outcomes. The aim of this study is to better understand the role of culturally specific (CS) providers of PSH in improving health equity. I analyzed interviews with CS PSH providers for themes related to health and healthcare. Providers spoke about the importance of connecting clients to healthcare. Providers stressed the importance of honesty and lived experience, highlighting the strong sense of responsibility to the community. Providers also …

Strategies To Improve Antibody-Mediated Protection Against Herpes Simplex Virus Infections, Matthew D. Slein

Dartmouth College Ph.D Dissertations

No efficacious vaccine exists for herpes simplex virus and the global burden of disease remains high. Antibodies can serve as potent therapeutics to protect high risk populations such as neonates. Although rare, neonatal HSV (nHSV) infections can result in significant mortality and lifelong neurological morbidity even with antiviral therapy. While HSV-specific maternally derived antibodies significantly reduce the risk of neonatal disease in humans, the mechanisms by which they mediate protection have yet to be described. Using a mouse model of neonatal HSV (nHSV) infections we aimed to determine the mechanisms of antibody-mediated protection using monoclonal antibodies (mAbs) targeting two of …

High-Throughput Repurposing Screen Reveals Compounds With Activity Against Toxoplasma Gondii Bradyzoites, Taher Uddin, Jing Xia, Yong Fu, Case W Mcnamara, Arnab K Chatterjee, L David Sibley

2020-Current year OA Pubs

No abstract provided.

C10-Benzoate Esters Of Anhydrotetracycline Inhibit Tetracycline Destructases And Recover Tetracycline Antibacterial Activity, Emily E Williford, Yao-Peng Xue, Wai Kwan Tang, Ruihao Li, Katherine V Jones, Kevin S Blake, Helen C Blaine, Xiang Lian, Christina L Stallings, Niraj H Tolia, Gautam Dantas, Timothy A Wencewicz

2020-Current year OA Pubs

Tetracyclines (TCs) are an important class of antibiotics threatened by enzymatic inactivation. These tetracycline-inactivating enzymes, also known as tetracycline destructases (TDases), are a subfamily of class A flavin monooxygenases (FMOs) that catalyze hydroxyl group transfer and oxygen insertion (Baeyer-Villiger type) reactions on TC substrate scaffolds. Semisynthetic modification of TCs (e.g., tigecycline, omadacycline, eravacycline, and sarecycline) has proven effective in evading certain resistance mechanisms, such as ribosomal protection and efflux, but does not protect against TDase-mediated resistance. Here, we report the design, synthesis, and evaluation of a new series of 22 semisynthetic TDase inhibitors that explore D-ring substitution of anhydrotetracycline (aTC) …

Expression Of A Single Inhibitory Member Of The Ly49 Receptor Family Is Sufficient To License Nk Cells For Effector Functions, Sytse J Piersma, Shasha Li, Pamela Wong, Michael D Bern, Jennifer Poursine-Laurent, Li-Ping Yang, Diana L Beckman, Bijal A Parikh, Wayne M Yokoyama

2020-Current year OA Pubs

Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like receptor family in humans play a central role in NK cell immunity through recognition of major histocompatibility complex class I (MHC-I) and related molecules. Functionally, these receptor families are involved in the licensing and rejection of MHC-I-deficient cells through missing-self. The Ly49 family is highly polymorphic, making it challenging to detail the contributions of individual Ly49 receptors to NK cell function. Herein, we showed mice lacking expression of all Ly49s …

Regional Government Preparedness In Response To The Covid-19 Pandemic In Indonesia, Eme Stepani Sitepu, Dumilah Ayuningtyas, Purnawan Junadi, Satibi Satibi

Journal of Health Research

Background: The high number of COVID-19 cases in Indonesia, with 6,811,201 people affected and 161,844 deaths up to June 2023, was influenced by regional governments' varying approaches to disease control. This study aimed to analyze regional government preparedness in response to the COVID-19 pandemic and the factors that influenced their preparedness.

Methods: We conducted a qualitative research study using purposive sampling. We collected data from September 2023 to April 2024 via semi-structured interviews with staff at health and disaster agencies in Bali and West Java. The interview guide was developed using the Six Building Blocks of World Health Organization (WHO)’s …

Knowledge And Attitude Towards Genetics And Genetic Testing Among Late Adolescents And Adults In Indonesia, Asyirah Mujahidah Fillah, Muh Akram, Clarissa Evangelina Hartono, Annette D'Arqom, Zakiyatul Faizah, Danti Nur Indiastuti, Nurina Hasanatuludhhiyah, Mhd Zamal Nasution, Junaidah Yusof

Journal of Health Research

Background: Despite the potential benefits, genetic testing has a negative stigma in Indonesia, leading to relatively low utilization. Without adequate knowledge, the incidence of genetic disorders could rise. Thus, a clear understanding of knowledge and attitudes towards genetics and testing among late adolescents and adults is crucial.

Method: A web-based questionnaire was administered between May and October 2022. Respondents (n= 467), composed of late adolescents (n= 332) and adults (n= 135), were recruited through social media and email. General genetic knowledge, perceptions about personal knowledge of genetic testing applications and its social implications, and the attitude toward genetic …

Experiences Of Caregivers Of Children With Covid-19 In Isolation Rooms: A Qualitative Study Conducted At Queen Sirikit National Institute Of Child Health In Bangkok, Thailand, Kidjapan Pinchai, Surasak Treenai, Chollada Jongsomjitt

Journal of Health Research

Background: Children were significantly impacted during COVID-19 surges, especially with highly transmissible variants like Delta. This study explored caregivers' experiences of children with COVID-19 in hospital isolation rooms, focusing on psychological and practical challenges.

Methods: Qualitative methods were used to describe the experiences of caregivers of children with COVID-19. Data were collected through in-depth interviews and from field and observation notes to capture reflections, ideas, and meanings. Content analysis was used to generate themes until saturation was reached with seven participants. The study was conducted at the Queen Sirikit National Institute of Child Health (QSNICH) in Bangkok, Thailand.

Results: The …

Polymicrobial Prosthetic Joint Infection Including Mycobacterium Tuberculosis: A Case Report, Hernan Andres Yunis, Zachary J. Walker, Matthew E. Charlick, Daniel P. Mccall

Posters

• Usual culprits of PJI affecting total hip and knee arthroplasty are Staphylococcus aureus and streptococcus epidermidis in the acute phase.

• During the chronic presentation, microbes become much more diverse as they may seed due to hematogenous spread from other body sites.

• The purpose of this case study was to illustrate an instance when polymicrobial total hip arthroplasty PJI included Mycobacterium Tuberculosis.

Exploring Creative Arts Therapists' Experiences With Online Therapy In South Korea During Covid-19, Changho Song

Expressive Therapies Dissertations

This study explored the experiences of creative arts therapists (CATs) in South Korea who conducted online therapy sessions during the COVID-19 pandemic. The global crisis forced a rapid shift to virtual platforms, raising concerns about the effectiveness of online creative arts therapy (OCAT) and its impact on therapeutic relationships. Grounded in phenomenological and arts-based research (ABR), this study examined the challenges, adaptations, and effectiveness of OCAT. The research addressed the following questions: (1) How did CATs experience the transition to online therapy? (2) What challenges did they encounter, and how did they adapt? (3) How did online therapy affect therapeutic …

Laryngeal Tuberculosis Mimicking Laryngeal Candidiasis, Claire Walters, Maranda Saigh, Eytan Keidar

Posters

Tuberculosis (TB) from the bacterium Mycobacterium tuberculosisand candidiasis from the fungus Candida albicansare both opportunistic pathogens with the ability to instigate infections within the larynx with similar clinical features, yet vastly different diagnostic parameters and treatment regimens.

Here, we highlight a case of an Indian woman on immune-modulating drugs who presented with severe laryngeal symptoms initially presumed to be laryngeal candidiasis but was later discovered to be laryngeal tuberculosis.

Adverse Childhood Experiences In Early Adolescence And Adult Interpersonal Relationships Violence, Jenalee M. Dawson

Walden Dissertations and Doctoral Studies

Intimate partner violence (IPV) is a pervasive social issue that affects individuals and communities, often rooted in early life experiences such as adverse childhood experiences (ACEs). Understanding the link between ACEs and IPV is crucial for developing effective prevention and intervention strategies. This quantitative research explored the potential link between ACEs encountered during early adolescence and the subsequent occurrence of IPV in adult domestic relationships, building upon the foundational work of Felitti et al. Using a quantitative survey design, 30 participants aged 18 and older who had experienced at least one ACE were recruited via social media and surveyed. Bandura's …

Leveraging Gis For Policy Design: Spatial Analytics As A Strategic Tool, Kathryn L. Hannum, Adam M. Wellstead, Michael Howlett, Anat Gofen

Michigan Tech Publications

We examine how geographic information system (GIS) tools contribute to policy design. Most accounts suggest that they merely generate information and data that can be used to enhance policy choices, a “design of services” perspective. More recent studies, however, suggest that GIS tools can also be used as procedural policy instruments, that is, to improve decision-making by facilitating stakeholder co-design and co-production processes, or what can be referred to as the designing “for” services. The activities of 57 GIS-based policy innovation labs (PILs) are examined. Seven critical but underutilized co-production activities that contribute to the attainment of public value are …

Comprehensive Review On The Application Of Bio-Immunoinformatics In The Development Of Highly Ef-Fective New Candidate Vaccines Against Tuberculosis, Ahyar Ahmad, Andriansjah Rukmana, Miski A. Khairinisa, Dian A. E. Pitaloka, Rosana Agus, Rusdina B. Ladju, Tarwadi Ahmad, Astutiati Nurhasanah, Carina C. D. Joe, Muhammad N. Massi, Harningsih Karim, Irda Handayani, Siti Roszilawati Binti Ramli

Karbala International Journal of Modern Science

Tuberculosis (TB) remains a significant public health challenge worldwide. Currently, Bacillus Calmette-Guerin (BCG) is the only vaccine available for TB prophylaxis. However, the efficacy of the BCG vaccine against adult pulmonary TB is considered inconsistent. This condition encourages researchers to look for more effective options, such as subunit vaccines. This condition requires the development of a more effective subunit vaccine to protect active TB in productive and adult ages. There is an urgent need for more effective vaccines, as the Bacillus Calmette-Guérin (BCG) vaccine currently available has inconsistent efficacy and is only partially effective in adults. Bio-immunoinformatics, an interdisciplinary field …

Everyday Life Information Behavior, Health Information Seeking, And Hiv And Sti Awareness Among People Who Inject Drugs (Pwid), Nafiz Z. Shuva, Radia Taisir, Parvez Sazzad Mallick

Publications and Research

This study aims to explore the everyday life and health information behavior of people who inject drugs (PWID) in Bangladesh, as well as the effectiveness of HIV and STI informational programs in promoting safe injecting and sexual behavior. The study received 97 completed survey responses and conducted two focus group discussions (FGDs) with 13 PWID. Using de Certeau's everyday life practices framework, the study aims to understand the tactical information strategies of PWID in the context of a developing country where access to government services and trust in authorities may be significantly limited among marginalized populations. PWID's information needs focused …