Digital Commons Network^™

Role Of Hdac1 In Type I Ifn Production By Macrophages And Dendritic Cells In Response To Tlr3 Stimulation And Mycobacterium Tuberculosis Infection, Andy Omeje

Biotechnology Theses

In this study we explored the role of histone deacetylases (HDACs), a group of epigenetic regulators, in production of type I interferon (IFN) by macrophages and dendritic cells (DCs) in response Mycobacterium tuberculosis (Mtb) infection and Poly I:C, a viral RNA mimic, stimulation. Human monocyte derived macrophages (MDMs) and DCs (MDDCs) stimulated with either Poly I:C or infected with Mtb produced elevated IFN-β and this was inhibited both at the protein and mRNA levels by 4-(dimethyl amino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (DHOB) and CAY10603 (CAY), chemical inhibitors targeting HDAC1. This was further supported by THP1-derived macrophages with HDAC1 knockdown producing reduced IFN-β …

Antibiotic Resistance And Molecular Characteristics Of Upcoming Pathogenic Kocuria Spp. Isolated From Iraq And Egypt, Maisam B. Al-Khamesi, Mohamed Khaled Ibrahim, Einas Hamed El-Shatoury, Iman Mohamed Amin El Kholy, Eslam Es Mikawye, Sahar T. M. Tolba

Baghdad Science Journal

Kocuria spp. isolates were collected from different clinical samples from Medical City Educational Laboratories/ Baghdad and Ain Shams Specialized Hospital, Cairo. Identification was carried out by VITEK2 automated compact system. Antibiotic susceptibility, biofilm formation, and detection of macrolides resistance genes ermA, ermB, ermC, msrA & mef, integron intI1 and intI2 were also investigated. Results indicated that 60 isolates were collected from the two countries, 42 isolates from Iraq, and 18 isolates from Egypt. The bacterial isolates were identified by their morphological and biochemical characteristics. They were susceptible to pipracillin/Tazobactam and vancomycin, resistant to …

Perianal Infections Update, Boris Garber, Jonathan Glauser

Faculty Scholarship

Purpose of Review We describe the evaluation, treatment, and disposition of patients presenting with perianal and rectal complaints, specifically focusing on identifying and treating various infectious diseases affecting this area. Risk factors and preventative strategies are also discussed where known. Recent Findings Several professional medical associations, namely the World Society of Emergency Surgery and the American Association for the Surgery of Trauma, recently promulgated new guidelines concerning the diagnosis and management of common infectious rectal disorders [1]. The American College of Radiology also published its criteria for choosing appropriate imaging modalities for anorectal disease [2]. Additionally, new meta-analyses have been …

Application Of Bioinformatic Tools To Tuberculosis Surveillance At The Arkansas Department Of Health, Brian Scott Delavan

Theses and Dissertations

Tuberculosis (TB) remains a public health threat in Arkansas. Great strides have been made over the past fifty years to reduce the number of TB cases in Arkansas. However, the rate of TB cases has remained steady since 2010. According to the Arkansas Department of Health, from 2012 through 2023 the TB Case rate per 100,00 population was between 2.0 and 3.1. To continue Arkansas’ drive towards elimination of TB in Arkansas, defined as one TB case per million residents, new data analysis tools are needed. This project employs multiple bioinformatic tools to analyze TB cases and latent tuberculosis infections …

Burnout, Life Satisfaction, And Meaning-Focused Coping In Correctional Mental Health Providers, Danielle Janet Tsamouris

Walden Dissertations and Doctoral Studies

Studies have found that burnout among correctional mental health providers is related to unique stressors that impact their physical, psychological, and emotional health, including the perceived and actual threat of violence. Using the transactional theory of stress and coping, the purpose of this quantitative study was to examine the influence of burnout and meaning-focused coping strategies on life satisfaction in correctional mental health providers. Online survey data from 102 master’s-holding correctional mental health professionals were recruited by SurveyMonkey who also administered the survey. Results from a standard multiple regression analysis suggested that meaning-focused coping strategies significantly and positively influenced life …

Artificial Intelligence Applications In Decision-Making For Disease Management A Scoping Review, Mohammadhiwa Abdekhoda, Fatemeh Ranjbaran Madiseh

Sultan Qaboos University Medical Journal

Artificial intelligence (AI) has several potential applications in medicine, creating opportunities for reliable and evidence-based decision-making in disease management. To explore the practical aspects of AI in decision-making, this scoping review was conducted to identify AI applications in disease management using the PRISMA-ScR checklist. Data collection involved searching relevant keywords in Web of Science and Scopus databases in May 2023. Eligibility criteria for study inclusion and exclusion were established, and the review process adhered to the PRISMA-ScR checklist. A total of 80 extracted sub-themes were identified and categorised into 6 main themes: data processing and management, characterisation and analysis, prediction …

Antibiotic Use By Paediatric Residents Of The Oman Medical Specialty Board: Identifying Opportunities For Antimicrobial Stewardship, Shaima Alshukaili, Hussain Al-Saffar, Hatem Al-Rawahi, Laila Al Yazidi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate antibiotic prescription knowledge and practices among Oman Medical Specialty Board (OMSB) paediatric residents. The goal was to identify educational opportunities to reduce antimicrobial resistance and improve patient care. Methods: A survey-based cross-sectional study was conducted among the OMSB paediatric residents from August 2023 to September 2023. The online survey involved three parts: residents’ demographics, knowledge of 12 common paediatric infection scenarios and clinical practice. Participants were asked to choose the proper antibiotic choices and duration for each scenario. Data analysis was performed using SPSS. Results: A total of 74 responses were obtained, resulting in …

Downregulation Of Biofilm Formation Genes In Some Pathogenic Bacteria By Extracts From Two Algal Genera, Nishtiman S Hasan, Janan J Toma, Abdulilah S Ismaeil, Suzan A Shareef, Muhsin J Abdulwahid

Baghdad Science Journal

Most infectious diseases are primarily caused by the growth of microorganisms called biofilms. The formation of bacterial biofilms enables microorganisms to inhabit biotic and abiotic surfaces which increases their resistance to antimicrobials. To control this issue, there is a critical need for novel approaches and compounds can suppress the expression or regulation of virulence genes. A potential method for disarming rather than eliminating bacterial pathogens is antivirulence therapy based on the blockage of biofilm pathways. In current study, the action of water, diethyl ether and acetone extraction on two types of algae namely Scenedesmus quadricauda and Chlorosarcinopsis eremi in their …

Planetary Health And Indigenous Sovereignty: Exploring The Theory Of Change Of The Healthy Environments And Lives (Heal) Network In Western Australia, Lucie O'Sullivan, Theoni Whyman, Mara West, Noel Nannup, Jaime Yallup Farrant, Naomi Joy Godden, Emma Leigh Synnott, Raewyn Mutch, Anita J. Campbell, Kylie Wrigley, Brad Farrant

Research outputs 2022 to 2026

This paper outlines the theory of change which underpins the Western Australian (WA) hub of the Healthy Environments and Lives (HEAL) network. HEAL is an Australian national research initiative that aims to address the health impacts of climate and environmental change. The WA hub's theory of change is focused on improving the health and well-being of the planet and people, including children, through centring Indigenous sovereignty, voices and ways of knowing and being in research, policy development and service provision. The WA hub also recognises it is essential for place-based, community-led solutions, which strengthens responses to climate and environmental change, …

Intouch Week Of May 19, 2025, New York Medical College

InTouch

• Vikas Grover, Ph.D., CCC-SLP, and Ronnie Myers, D.D.S., Named Healthcare Heroes by Westchester Magazine
• Annual Louis Del Guercio, M.D., Research Day Showcases Outstanding Surgical Research
• NYMC Celebrates Homecoming 2025 with Alumni, Students, and Campus Tours
• Teaching and Learning Symposium Brings Faculty Together to Enrich Their Educational Practice
• Philip Kuehl, Ph.D., Addresses Drug Development Problem Statements at the Neighborhood Science Seminar Series
• 185 TCDM Students Don White Coats as They Head to Touro Dental Health Clinics in New York and New Mexico
• Student Spotlight: David Zuckerman to Address Graduates Before Beginning Neurology Residency at NYU

Leading Through Crisis: San Diego County Schools' Response To The Social Emotional Needs Of All Students, Johana Bielma

Dissertations

The COVID-19 pandemic led to unprecedented school closures, forcing administrators to take decisive action to radically change the educational system. The imperative to switch to remote learning transformed the dynamics of teaching and learning, leading to both immediate and long-term academic and social emotional consequences for all stakeholders. When schools reopened, administrators faced the challenge of reintegrating students into in-person learning while addressing the pandemic’s lasting effects on academics, mental health, and school safety. While academic regression was evident, the extent of students’ emotional struggles was less anticipated. Many students exhibited increased irritability and mental health issues such as depression …

How Mass Incarceration Has Destroyed African American Communities, Angeliki Karvounis

Themis: Research Journal of Justice Studies and Forensic Science

Beginning with the “Tough on Crime” movement of the 1970s, policies such as mandatory minimums, the War on Drugs, and the Three Strikes law have reinforced racial disparities in the criminal justice system. Multiple historical and systemic factors have contributed to the disproportionate imprisonment of African American individuals. This paper explores the long-term consequences of incarceration, including the erosion of family structures, the economic marginalization of affected communities, and the perpetuation of poverty and crime. The repercussions of parental incarceration on children and the challenges faced by formerly incarcerated individuals seeking reintegration into society are examples of the long-term consequences …

Human Trafficking: An Examination Of Policies And The Impact Of Trafficking On Victims, Hannah Lyons

Themis: Research Journal of Justice Studies and Forensic Science

Human trafficking is a pervasive and complex global issue that involves the exploitation of individuals. While there is also the trafficking of objects, this study solely focuses on sexual exploitation and forced labor of humans. This paper defines trafficking and examines the impact that trafficking has on victims’ physical and mental health. This paper also examines the intersection of human trafficking and policies designed to combat it, focusing on the effectiveness of legal frameworks and enforcement mechanisms. By analyzing the strengths and weaknesses of current anti-trafficking laws and initiatives, the paper explores how policies can be improved to better address …

Physiological Regulation And Paths To Social Status In Chimpanzees, Megan F. Cole

Anthropology ETDs

In this dissertation, I leverage longitudinal comparative data from naturalistic chimpanzee populations to examine the evolutionary context for healthy aging and cooperative leadership. First, I use health data from semi-free-ranging chimpanzees living at African sanctuaries (2012-2023) to demonstrate that the effects of diet and exercise that promote healthy aging in humans are shared with chimpanzees. Semi-free-ranging chimpanzees exhibit a slower pace of biological aging compared to sedentary laboratory chimpanzees (Chapter 2). Sanctuary chimpanzees also have healthier inflammatory profiles, with no evidence of chronic inflammaging (Chapter 3). Second, I use hormonal and behavioral data from wild chimpanzees at Kanyawara (2005-2019) to …

Music Therapy And Cerebral Visual Impairments (Cvi) In Early Childhood: A Literature Review, Katie Hock

Expressive Therapies Theses

Cerebral visual impairment (CVI) is the leading cause of visual impairment in children within the United States, and results from neurologic impairment to areas of the brain responsible for processing and interpreting visual input. Due to the brain-based nature of this impairment, improvement in functional vision is possible through the process of neuroplasticity and development of compensatory strategies to improve personal access to the environment and surroundings. Intact vision provides access to information about the world around us, and without this sense children are highly susceptible to developmental delays in the areas of cognition, motor skills, communication, and social functioning. …

Addressing Socioeconomic Disparities In The Treatment Of Antimicrobial-Resistant Infections: The Role Of Pharmacists In Mitigating Barriers, Arin Wade, Danielle Egbujor, Anna Spalvieri, Owen Fox, Marisa Petrunich, Joshua Honaker, Samantha Mccord, Kasie Landin

Pharmacy and Wellness Review

Antimicrobial resistance is an escalating global threat driven by inappropriate antibiotic use and shaped by socioeconomic disparities. Social determinants of health, including limited healthcare access, poverty, low health literacy, and environmental conditions, contribute to higher rates of resistant infections and poorer treatment outcomes in underserved populations. Barriers such as pharmacy deserts, self-medication, and inadequate stewardship infrastructure amplify these risks. Pharmacists, as accessible and highly trained healthcare professionals, play a critical role in combating antimicrobial resistance by optimizing antibiotic use, delivering culturally competent education, and leading antimicrobial stewardship programs across settings. Community and clinical pharmacists are especially well positioned to bridge …

Prevalence Of Urine Culture Contamination In A Primary Care Outpatient Setting In Muscat, Oman: A Retrospective Cross-Sectional Study, Rahma Al Hadhrami, Asma A. Al Salmani, Abeer Al Houdar, Janit Francinilla, Abeer Albalushi, Buthaina Al Maskari

Sultan Qaboos University Medical Journal

Objectives: This study aimed to investigate the prevalence of urine culture contamination, determine related factors and identify the most prevalent uropathogens among samples collected from outpatients attending a primary healthcare setting in Muscat, Oman. Methods: This retrospective, cross-sectional study was conducted from June 2022 to July 2023 at the primary health clinic of Sultan Qaboos University Hospital, Muscat, Oman. All urine cultures requested by physicians for ambulatory outpatients who attended the clinic during the study period were included. Collected urine samples underwent microbiological analysis, with positive cultures defined as significant growth of ≥10⁵ colony forming unit (CFU)/mL. Samples exhibiting …

Exploring Anticoagulation Trends As Early Infection Markers In Pediatric Ecmo And Crrt Patients, Samantha Davidson, Jay Rilinger, Jenna Miller, Caroline Holton, Joshua Herigon, Brian Lee

Research Days

This retrospective cohort study at a tertiary pediatric hospital included ICU patients who developed infections after 72 hours on extracorporeal support from 2017-2023. We assessed whether the number of anticoagulation dose changes are linked to acquired infections.

Viral Detection In Anterior Nasal Swabs Versus Nasopharyngeal Swabs In Children, Nicole Neeley, Abby Kietzman, Rangaraj Selvarangan, Dithi Banerjee, Jennifer Goldman, Jennifer Schuster

Research Days

Background: Respiratory viruses are a significant cause of pediatric illness and healthcare utilization. Diagnostic testing for respiratory viruses is generally performed using nasopharyngeal (NP) specimens obtained by trained staff, limiting testing to medical settings. Evaluating additional sampling methods in children that are easier to collect and can be performed outside of medical settings, such as anterior nasal swab (NS) specimens may expand access to diagnostic testing and aid public health surveillance.

Methods: Eligible children hospitalized at Children’s Mercy Hospital who had a standard of care NP specimen collected for respiratory viral testing were enrolled. Research NS specimens were obtained through …

Tacrolimus Dosing In Liver Transplant Recipients Using Phenotypic Personalized Medicine: A Phase 2 Randomized Clinical Trial, Jeffrey Khong, Megan Lee, Curtis Warren, Un Kim, Sergio Duarte, Kenneth Andreoni, Sunaina Shrestha, Mark Johnson, Narendra Battula, Danielle Mckimmy, Thiago Beduschi, Ji-Hyun Lee, Derek Li, Chih-Ming Ho, Ali Zarrinpar

Department of Surgery Faculty Papers

Tacrolimus is the most commonly used immunosuppression drug after solid organ transplantation; however, its dosing is challenging due to substantial inter-individual variability, often resulting in blood levels that deviate from the target therapeutic range. We explored whether a dynamically customized, phenotypic-outcome-guided drug dosing method could improve maintenance of drug trough levels within pre-determined target ranges, focusing on tacrolimus immediately after liver transplantation. This single-center, partially blinded, completed clinical trial involved 62 adults undergoing liver transplantation, block randomized into parallel groups: standard-of-care (SOC) clinician-determined or Phenotypic Personalized Medicine (PPM)-guided tacrolimus dosing. The primary outcome was percentage of post-transplant days with large …

Monoclonal Antibodies Targeting Candida Disrupt Biofilms And Inhibit Growth Across Global Clinical Isolates, Jonothan Rosario-Colon, Karen Eberle, Hong Xin

School of Graduate Studies Faculty Publications

Candida species are a major cause of severe fungal infections, particularly in immunocompromised individuals and hospitalized patients. Among these, Candida auris stands out as an emerging “superbug”, responsible for life-threatening bloodstream infections with mortality rates up to 60%. This multidrug-resistant, hospital-acquired pathogen has been declared a serious global health threat, complicating effective treatment and increasing mortality risks. Our research has identified universal monoclonal antibodies (mAbs) targeting Candida albicans cell wall epitopes, which are highly homologous to those in other pathogenic Candida species, including C. auris. Passive transfer of mAbs—C3.1 (anti-β-1,2-mannotriose) and 9F2 (anti-phosphoglycerate kinase 1)—significantly extended survival and improved fungal …

Epidemiological And Clinical Characteristics Of Children With Measles In Babil Governorate In 2024, Hasan Alwan Baiee, Zainab Hamed Abdel Qader, Zahraa Hossam Abdul Hussein, Ali Mohsen Flih

Hilla University College Journal For Medical Science

Background: Measles considered a highly contagious and serious disease affecting mainly children in their early years, with morbidity and mortality. The effective preventive measure against measles is vaccination.

Objective: To identify the epidemiological characteristics of patients with measles admitted to Maternity and Children’s Teaching Hospital in Babylon Governorate.

Materials and Methods: A hospital-based cross-sectional study was conducted using structured questionnaire on convenient sample of children infected with the measles virus and hospitalized in Maternity and Children’s Teaching Hospital, Babylon Governorate, Iraq. During three-monthperiod from the first of January to 30^th of March, 2024. A special semi-structured validated and reliable …

Are We Ready For Ai-Augmented Generalists?, Jiajie Zhang

Faculty, Staff and Student Publications

Artificial Intelligence (AI) is reshaping medical practice and education by unifying the knowledge of medical specialties and subspecialties into a single, intelligent system. This system functions not only as an integrated knowledge base but also as an active cognitive collaborator. By bridging knowledge gaps beyond the capacity of any individual clinician, AI could enable physicians to function as AI-augmented generalists who can perform certain tasks that require specialist training. These generalists may help mitigate care fragmentation, but realizing their potential will require significant changes in medical education.

Lead And Iron Levels In Maternal And Umbilical Cord Blood In Basrah, Iraq, Balqees Kadhim Hasan, Jafar Sadek Abdulazeez, Meaad Kadhum Hassan, Hamid Jaddoah Abbas, Lamia Mustafa Al-Naama

Sultan Qaboos University Medical Journal

Objectives: Lead can pass from a mother to her developing foetus and is associated with well-established risks for the foetus. This study aimed to evaluate maternal and cord iron and lead levels and study the association of maternal and cord blood lead levels (BLLs) with newborn anthropometric measurements. Methods: This cross-sectional study was conducted at Basra Maternity and Children Hospital, Basrah, Iraq, and included women and their newborns over the period from January through June 2023. Blood samples from mothers and umbilical cords were collected and sent to determine the complete blood count and lead and iron levels. Linear …

Prevalence Of Viruses In Odontogenic Cysts And Tumours: A Systematic Review Of Literature And Meta-Analysis, Deepak Pandiar, Divya Gopinath, Pinky Pavithran, Reshma Poothakulath Krishnan, Jishnu Krishna Kumar, Sajesh K. Veettil

Sultan Qaboos University Medical Journal

This review aimed to assess the prevalence of oncogenic and non-oncogenic viruses in odontogenic cysts and tumours. A comprehensive database search was performed for published articles regarding the presence of viruses in all odontogenic cysts and tumours, following guidelines without date constraints, and was registered with PROSPERO. After screening 164 articles, 24 studies were included for systematic evaluation. A meta-analysis was performed to determine the prevalence of human papillomavirus (HPV), revealing an overall pooled prevalence of HPV in ameloblastomas of 18.21% (95% confidence interval [CI]: 6.36–33.73) while the prevalence of HPV in odontogenic cysts was found to be 1.51% (95% …

Urinary Tract Infections Among Patients In Primary Healthcare Centres In Bahrain: A Cross-Sectional Study, Mahmood Alawainati, Zahra Ayoob, Eman Almajed, Safaa Alkhawaja, Noof Abdulaal, Rehab Alkhnaizi, Hanin Shaheen, Fatema Hubail, Nermin Kamal Saeed

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine the clinical and microbiological profiles of patients with urinary tract infections (UTIs) in primary healthcare centres in Bahrain. Methods: This retrospective cross-sectional study was conducted at 27 primary care centres in Bahrain between January and December 2022. All patients with positive urine cultures, defined as the presence of ≥100,000 colony-forming units/mL were included. Participants’ sociodemographic characteristics, comorbidities, risk factors for resistant uropathogens, uropathogen types and antibiotic sensitivity outcomes were assessed. Descriptive and inferential statistics were analysed. Results: A total of 1,985 patients were included, with an average age of 40.57 ± 20.18 years. Most …

Evaluating San Francisco Urban Green Spaces And Policy To Inform Future Decision-Making: How Climate Change Adaptation Strategies Can Be Prioritized And Incorporated In Urban Park Design And Planning Through A Decision-Making Tool, Holley Anne Maassen

Master's Projects and Capstones

Amid the current climate crisis, enhancing urban green spaces (UGS), parks, and open spaces with climate change adaptation (CCA) as a strategic pillar in San Francisco’s urban planning is an essential strategic pillar to develop more resilient cities. However, in complex bureaucratic landscapes, integrating CCA strategies that meet project goals while ensuring inclusive stakeholder engagement presents a challenge. This project presents the identification, development, and application of a holistic decision-making tool (DMT) in the form of a Pugh matrix/decision matrix and with a focus on urban planning in San Francisco, California. Key decision-making criteria are identified and weighted through a …

Plastic In The Pack: Assessing Microplastic Risk To Urban Coyotes (Canis Latrans) In The San Francisco Bay Area, Elaina E. Herrmann

Master's Projects and Capstones

Microplastics are an emerging concern worldwide. However, their impact on terrestrial mammals, such as Canis latrans (coyotes), has yet to be extensively studied. Coyotes are unique in their ability to adapt to urban environments and have recently begun bridging the gap between marine and terrestrial food webs. This research examines the potential sources and impact of microplastic exposure in urban coyotes in the San Francisco Bay Area and possible food web impacts through literature synthesis and Geographic Information System (GIS) mapping. This research examined potential mechanisms for direct and trophic microplastic uptake by coyotes resulting from the anthropogenic, terrestrial, and …

Negotiating Migration In The Mediterranean: A Comparative Study Of Morocco And Italy’S Border Policies And Their Humanitarian Impact On Irregular Migrants, Shennel Ep Henries

Master's Theses

Serving as both a barrier and a bridge that connects Africa and Europe, the Mediterranean is today the focal point of global controversies around migration, where humanitarian interests balance against border policing and meet securitization policies. This thesis examines the questions: How do irregular migrants adapt, interpret, and maneuver around securitized Moroccan and Italian migration policies, and what do their strategies tell us about the relationship between humanitarianism and securitization in Mediterranean bordering processes? Drawing on qualitative evidence, including expert interviews with organization employees and volunteers in Morocco and Italy (Fondazione Solidarietà Caritas, Nosotras Onlus, and Caritas Maroc), field observation, …

Assessment Of Pagp Gene Function In Avian Pathogenic Escherichia Coli Pathogenicity Using Different Challenge Models, Hailey Fugate

Theses and Dissertations

Avian pathogenic Escherichia coli (APEC) is a leading cause of morbidity and mortality in poultry, contributing an estimated $40 million in annual losses in the U.S. broiler industry alone, and contributing to growing concerns over antibiotic resistance. This study investigated the role of the pagP gene, which encodes a lipid A palmitoyl transferase involved in immune evasion, using both a broiler chick and embryo challenge model. Deletion of pagP significantly reduced mortality and lesion severity in broilers, indicating its role in APEC pathogenicity. However, in embryos, pagP deletion had minimal effects on survival and bacterial colonization, suggesting alternative virulence mechanisms …