Digital Commons Network^™

Dismissing Human Trafficking: Forced Arbitration Of Survivors’ Civil Suits, Annie Smith, Daniel Werner

Villanova Law Review (1956 - )

No abstract provided.

Implementation Of An Educational Intervention To Improve Antibiotic Stewardship In An Urgent Care Setting, Evelyn Jane Clinton

Doctoral Dissertations and Projects

Antimicrobial resistance is a leading threat to global health. Resistance to antibiotics in the United States continues to increase contributing to rising numbers of resistant infections and subsequent deaths. This highlights the critical need for increased focus on antibiotic stewardship efforts. Urinary tract infections are one of the leading indications for antibiotic prescription in the outpatient setting and research suggests that there is an opportunity for improvement in antibiotic stewardship efforts in this area. The PICOT question for this project is as follows: In an urgent care setting, does provider education on the current evidence for urinary tract infection diagnosis …

Performance Of A Novel Stool Quantitative Polymerase Chain Reaction Assay For Pediatric Tuberculosis Detection In Sub-Saharan Africa, Anca Vasiliu, Lucia Carratala-Castro, Abigail Seeger, Joanna Ehrlich, Babongile Nkala, Tara Ness, Miguel Mario Cumbe, Durbbin Mulengwa, Shilzia Munguambe, Bariki Mtafya, Edson Mambuque, Nosisa Shiba, Sozinho Acacio, Lilian Komba, Clement Gascua Adu-Gyamfi, H Lester Kirchner, Christoph Lange, Andrew R Dinardo, Alberto L Garcia-Basteiro, Anna Maria Mandalakas, Alexander Kay

Faculty, Staff and Students Publications

Background: Children have paucibacillary tuberculosis and cannot provide expectorated sputum. Invasive specimen collection, by gastric aspiration or sputum induction, has a low diagnostic yield. In this study, we aimed to evaluate the diagnostic performance and additive yield of a novel stool-based assay in children diagnosed with tuberculosis in sub-Saharan Africa.

Methods: We conducted a prospective case-control study from October 2020 to June 2023 in Eswatini, Mozambique, and Tanzania. Children under 15 years newly diagnosed with tuberculosis completed clinical examination, chest radiography, culture, sputum Xpert Ultra, stool Xpert Ultra, and stool-based quantitative polymerase chain reaction (stool qPCR) assessment. Stool qPCR sensitivity …

Adenovirus Species In U.S. Children With Acute Respiratory Illness, 2016-2019, Varvara Probst, Tess Stopczynski, Justin Z Amarin, Adam Gailani, Herdi K Rahman, Laura S Stewart, Rangaraj Selvarangan, Jennifer E Schuster, Marian G Michaels, John V Williams, Julie A Boom, Leila C Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P Schlaudecker, Christina Quigley, Christopher J Harrison, Mary E Moffatt, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Aaron T Curns, Heidi L Moline, Ariana P Toepfer, Susan I Gerber, James D Chappell, Andrew J Spieker, Natasha B Halasa

Faculty, Staff and Students Publications

Background: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI). HAdV-B, -C, and -E species have been associated with ARI, though relative detection frequencies in United States (U.S.) and respective roles in symptomatic respiratory infections remain unclear.

Methods: We conducted a multicenter, prospective viral surveillance study at 7 U.S. children's hospitals comprising the New Vaccine Surveillance Network from January 12, 2016 to November 30, 2019. Children < 18 years old in the emergency department or hospitalized with fever and/or respiratory symptoms were enrolled, and respiratory specimens were tested for HAdV and other viral pathogens. HAdV-positive specimens were subsequently typed using single-plex real-time PCR assays targeting sequences in the hexon gene. Demographics, clinical characteristics, and outcomes (hospitalization and supplemental oxygen use as severity indicators) were compared between HAdV-B and HAdV-C species.

Results: Of the 29 381 children with ARI, 1843 (6.3%) had HAdV detected, with 1402 specimens (76.0%) successfully typed. HAdV-C was the most frequently detected species (73.0%), followed by HAdV-B …

A Tubo-Ovarian Abscess In Aplastic Anemia Presenting As Fever Of Unknown Origin, Rashi Mittal, Saurabh Kumar Gautam, Prasan Kumar Panda, Latika Chawla

Chulalongkorn Medical Journal

This report describes a complex case of a tubo-ovarian abscess (TOA) presenting atypically as fever of unknown origin (FUO) in a young woman initially diagnosed with severe aplastic anemia. The case involved protracted febrile illness, heavy menstrual bleeding, and pancytopenia. Identification of an Escherichia coli tubo-ovarian abscess, rather than tuberculosis, emphasized the need for a thorough evaluation in atypical presentations of TOA. Negative tuberculosis tests highlighted the variety of possible microbial etiologies. The resolution of fever following drainage and tailored antibiotic therapy, along with timely surgical intervention, demonstrated the importance of specific management strategies in such cases. Awareness of the …

The Impact Of Polymycovirus 1 On Aspergillus Fumigatus Pathogenesis During Lung Infection, Alexander W. Rapp

Dartmouth College Ph.D Dissertations

The genus Aspergillus comprises over 250 species of fungi. Within this genus, only a handful of species cause disease in humans. One species is Aspergillus fumigatus (A.f.), an environmentally ubiquitous, saprophytic fungal pathogen. Lung infections due to A.f. range from invasive infection to allergic forms of the disease. Allergic bronchopulmonary aspergillosis (ABPA) is one of the most severe forms and presents as a hypersensitivity that often results in off-target damage to the surrounding airways. Patients with ABPA are sensitized to fungal antigens and this is commonly seen in cystic fibrosis and genetic predispositions. Recent data from our lab shown how …

Macrophage Heterogeneity And Function In The Lung, Xin Li

Dartmouth College Ph.D Dissertations

Macrophages are critical custodians of the lung, orchestrating immune surveillance, maintaining tissue homeostasis, and coordinating both innate and adaptive responses. This dissertation examines their heterogeneity and specialized functions, focusing on IMs, which reside in the lung interstitium, and AMs, which occupy the airspace. Through comprehensive single-cell transcriptomic profiling of murine and human samples, we identify multiple IM and AM subsets defined by distinct chemokine, cytokine, receptor, and innate immune gene signatures. These subsets display clear divisions of labor, contributing to immune cell recruitment, tertiary lymphoid structure formation, and alveolar homeostasis.

In IMs, coordinated chemokine programs not only recruit inflammatory cells …

Working Paper No. 98, Selma Mushkin And The Emergence Of The Field Of Health Economics, Sadie Kautz

Working Papers in Economics

This inquiry seeks to establish that through her effective efforts, Selma Mushkin promoted and shaped the field of Health Economics. Perhaps most importantly, she redefined health as a form of human capital that needed to be considered as both essential and integral to economic growth. In her 1958 paper: “Toward a Definition of Health Economics,” she defined the scope of this emerging field through emphasizing how improved resource allocation could lead to efficiency gains. Appearing as her 1962 article in the Journal of Political Economy, with “Health as an Investment” Mushkin advanced the idea that--much like education--public spending on health …

Type I Interferon Protects Against Bone Loss In Periodontitis By Mitigating An Interleukin (Il)-17-Neutrophil Axis, Jinmei Zhang, Qiong Ding, Angela X Wang, Maoxuan Lin, Ning Yu, Kevin Moss, Megumi A Williamson, Di Miao, Julie T Marchesan, Erliang Zeng, Wei Shi, Hongli Sun, Yu Leo Lei, Shaoping Zhang

Faculty, Staff and Student Publications

Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation. Disruption of IFN-I signaling worsened alveolar bone resorption in a ligature-induced periodontitis murine model. Deficiency of the IFN-I pathway resulted in an exaggerated inflammatory response in myeloid cells and drastically increased the interleukin-17 (IL-17)-mediated neutrophil recruitment in the gingiva. We further identified that the myeloid …

Freedom To Misinform: The First Amendment Victory Against California’S Medical Speech Law, Brennan O'Boyle

Loyola of Los Angeles Law Review

In 2022, California was grappling with the COVID-19 pandemic. Heightened political polarization and the unmitigated spread of misinformation was straining state and federal governments’ ability to rein in the pandemic through collective action. The Federation of State Medical Boards (FSMB) issued a warning that doctors spreading misinformation were violating their ethical and professional responsibility to accurately inform their patients. In response, California passed AB 2098, classifying COVID-19 misinformation in the patient-doctor context as unprofessional conduct subject to stiff penalties, including suspension or loss of the offender’s medical license. The law was quickly challenged in federal district court on content-neutrality and …

Versatile Imidazole Scaffold With Potent Activity Against Multiple Apicomplexan Parasites, Monique Khim, Jemma Montgomery, Mariana Laureano De Souza, Melvin Delvillar, Lyssa J. Weible, Mayuri Prabakaran, Matthew A. Hulverson, Tyler Eck, Rammohan Y. Bheemanabonia, P. Holland Alday, David P. Rotella, J. Stone Doggett, Bart L. Staker, Kayode K. Ojo, Purnima Bhanot

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Malaria, toxoplasmosis, and cryptosporidiosis are caused by apicomplexan parasites Plasmodium spp., Toxoplasma gondii, and Cryptosporidium parvum, respectively, and pose major health challenges. Their therapies are inadequate, ineffective or threatened by drug resistance. The development of novel drugs against them requires innovative and resource-efficient strategies. We exploited the kinome conservation of these parasites to determine the cellular targets and effects of two Plasmodium falciparum inhibitors in T. gondii and C. parvum. The imidazoles, (R)-RY-1-165 and (R)-RY-1-185, were developed to target the cGMP dependent protein kinase of P. falciparum (PfPKG), orthologs of which are present in T. gondii and C. parvum. Using …

Political Ecologies Of The Livestock Industry, Jecca Bowen

Electronic Theses and Dissertations

In the United States today, livestock production is dominated by an intensified, industrialized production paradigm whose growth in recent decades has utterly transformed the logistical realities and community impacts of animal agriculture. This dissertation investigates the effects of this production paradigm on livestock producers—whose decision-making is shaped by multi-scalar and often contradictory forces—as well as residents living near these large operations. To do so, I draw upon mixed-methods fieldwork, including in-depth interviews, spatial analysis, and field odor measurements in Weld and Morgan Counties in northern Colorado. I also use political ecologies of emotion, embodiment, and health to examine the complex …

Enhancing Delirium Prediction And Prevention In Elderly Patients Through Machine Learning-Based Analysis, Abdullah M. Al Alawi, Juhaina S. Al Maqbali

Sultan Qaboos University Medical Journal

Objective: This study aimed to identify predictors of delirium within 24 hours of admission in elderly patients using machine learning (ML) models and evaluate their performance. Methods: This prospective cohort study was conducted among patients aged 65 years and older admitted to the general medical unit of Sultan Qaboos University Hospital, Muscat, Oman, from January 2022 to May 2023. Clinical and demographic data were collected and analysed using 4 ML models: logistic regression, random forest, gradient boosting and support vector machine. Model performance was evaluated using accuracy, precision, recall, F1 score and area under the curve-receiver operating characteristic …

Equal Rights And Protections In Human Subjects Research: A Call To Action, Leslie E. Wolf, Laura M. Beskow

Journal of Health Care Law and Policy

No abstract provided.

“Do No Harm,” Unless God Says So? The Unholy Conflict Of Religious Objections In Health Care, Brandon Hernandez

Journal of Health Care Law and Policy

No abstract provided.

Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley

Dissertations

Bacteria have become increasingly resistant to antibiotics, therefore there is an urgent need for new drug classes of antibiotics to help fight antibiotic infections. To this end, our research is focused on inhibitors of dizinc metalloenzymes N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), an enzyme in the lysine biosynthesis pathway, N-acetyl-L-ornithine deacetylase enzyme (ArgE), an enzyme in the arginine biosynthesis pathway, and sodium-dependent NADH: ubiquinone oxidoreductase (Na+-NQR) enzyme, a respiratory complex enzyme as promising drug targets. DapE, ArgE, and Na+-NQR and are only present in bacteria, including ESKAPE pathogens that can cause potentially deadly infections, thus inhibitors of DapE, ArgE, and Na+-NQR offer …

A Spatial Modeling Framework For Identifying Multidimensional Risk Factors Of Colorectal Cancer, Johnna K. Berryhill

Student Theses and Dissertations

Colorectal cancer (CRC) is one of the most common and preventable cancers, yet significant disparities in screening, incidence, and late-stage diagnosis persist across different geographic and socioeconomic contexts. This thesis presents a spatial modeling framework for identifying multidimensional risk factors associated with CRC outcomes across various geographic scales. Using county- and census-tract-level data from national and state sources, the study integrates demographic, socioeconomic, environmental, built environment, and behavioral predictors to analyze geographic variability in CRC risk factors. Advanced spatial modeling techniques, including Geographically Weighted Regression (GWR) and Geographically Weighted Random Forest (GW-RF), are employed to capture spatial heterogeneity in these …

Functional Characterization Of Uncharacterized Essential Genes In The Oral Pathogen Streptococcus Mutans, Courtney Dover

Student Theses and Dissertations

Streptococcus mutans is a pathogen associated with the formation of dental caries, and its genome contains many uncharacterized genes, including some which are classified as essential genes. These genes are required for the growth of the organism. Characterizing the function of these genes is important for understanding the organism, as well as identifying potential antimicrobial targets. This project used a CRISPRi (CRISPR interference) system to repress seven experimentally uncharacterized genes within the S. mutans genome and investigated the effects of their repression via RNA-seq transcriptomics, phylogenetic analysis, and TEM. The gene annotated as SMU_393 was then prioritized for further analysis …

Strengthening Global Health Education In The Uae: Assessing The Current Landscape And Future Directions, Ali Artaman, Hillani T. Bekele, Ross Millar

All Works

Global health is a growing area of interest for the United Arab Emirates (UAE). Given its location in the Middle East and its geographical proximity to developing sub-Saharan countries, the country is in a strategic position to contribute to global health agendas. Yet despite an increasing emphasis on global health policy, the availability of global health education programs at UAE universities remains limited. The aim of this Perspective is to raise awareness and understanding about the importance of the issue. Reflecting on the current landscape, it argues that it is crucial for higher education institutions in the UAE to better …

Who Seeks Help? A Sociodemographic Analysis Of Cannabis Use Disorder Treatment In New York, Ayodele Atolagbe, Ekenedilichukwu Theresa Emembolu, Stanley Nkemjika

Department of Psychiatry and Human Behavior Faculty Papers

Introduction: Cannabis use disorder (CUD) is being increasingly diagnosed in the United States, but access to treatment remains unequal, particularly in New York. Identifying the factors that contribute to disparities in receiving treatment for CUD among different population groups is essential for ensuring effective and targeted interventions. This study explores the sociodemographic factors influencing treatment utilization for CUD in New York.

Methods: Data for this study were retrieved from the 2018 Treatment Episode Data Set—Discharges (TEDS-D) of the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA). Sample size for the study is 422,319 people with CUD. Logistic regression analysis …

Captured And Enhanced Potentials Of Wild Edible Fruits In Tabora Rural, Uyui And Sikonge Districts, Tabora In Tanzania, Mirau N. Mbise

Journal of Humanities and Social Sciences

Rural communities worldwide supplement food and income through wild edible fruits. However, the paucity of scientific inquiry on the perceptions and uses of wild edible fruits, value-addition, and marketing prompted this study. It interviewed respondents from 274 households in Tabora rural, Sikonge, and Uyui districts in the Tabora region of Tanzania. Descriptive and quantitative analyses were undertaken, and results showed that wild edible fruit activities are perceived to be for women, children, and less-educated people. Furthermore, the findings indicated that 100% (n = 274) of the respondents use wild edible fruits as food, and 48.6% (n = 133) use them …

Measuring Healthcare Quality For Sexual Minority Women, Francesca Antoine

Walden Dissertations and Doctoral Studies

Women who identify as lesbian, bisexual, or other sexual orientations (i.e., sexual minority women) experience poorer health outcomes compared to heterosexual women. Despite the increasing prevalence of sexual minority women in the United States, little research exists to identify their unique health needs. Healthcare administrators play a critical role in promoting a higher standard of patient care by identifying systemic issues and leveraging data-driven solutions. The purpose of this study was to examine various aspects of care delivery in clinical encounters involving sexual minority women and evaluate their perception of care quality. Donabedian’s model of healthcare quality served as the …

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests On Respiratory And Stool Samples With Or Without Lateral Flow Lipoarabinomannan Assays To Detect Pulmonary Tuberculosis Disease In Children, Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, Mathias Weis Damkjær, Alexander W Kay, Johanna Åhsberg, Ruvandhi R Nathavitharana, Ian Schiller, Nandini Dendukuri, Andreas Lundh, Maunank Shah, Stephanie Bjerrum, Devan Jaganath

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular assays widely used to diagnose tuberculosis disease in children. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended for use amongst children with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM separately in children, but in clinical practice the tests may be used concurrently, i.e. in 'parallel'.

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory and stool specimens in children, and with LF-LAM on urine amongst children with HIV, versus each assay alone for detecting pulmonary tuberculosis disease.

Search …

A Survey Of Practice Models And Outcomes In Michigan Residential Substance Use Disorder Treatment, Lamart Hightower, Elissa Kent, Vikash Kumar, Lauren Michie, Alysha King, Tekoa Marshall

Journal of Social Work in the Global Community

The United States has a lengthy history of treating individuals experiencing substance use disorders (SUDs) from an abstinence-only framework. Harm reduction practices have grown a large base of empirical support in other parts of the world and have become central to treating individuals with SUDs. Within the United States, however, a substantial number of residential SUD treatment programs that continue to perpetuate an abstinence-only framework, which creates a lack of access for people who seek a harm reduction approach—and who likely need it the most. In this study, 66 residential treatment programs in Michigan were examined to determine whether they …

Incidence Of Scabies Among Patients Attending Al-Faihaa Educational Hospital In Basra Province / Iraq., Sarah Kamal Naser

Maaen Journal for Medical Sciences

Background: In 2017, scabies was officially classified as a neglected tropical illness by the World Health Organization (WHO), in an attempt to raise awareness and support initiatives to eradicate it. Additionally, the WHO's strategy for neglected tropical diseases 2021-2030 has recently included scabie, intended to prevent the Sustainable Development Goals from being neglected, in recent years, scabies appears to have grown widespread in Iraq most likely as a result of the country's densely populated areas and high levels of interpersonal interaction, this study fills crucial gaps and offers nuanced insights into the prevalence of scabies in Basra prevalence, the cross-sectional …

The Impact Of Hazard Naming In Wireless Emergency Alerts: Enhancing Protective Action Decision Making And Organizational Attitudes, Micki Olson, Hugh Walpole, Jeannette Sutton, Lauren B. Cain, Nicholas Waugh

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Wireless Emergency Alerts are an important way people learn about impending threats. Yet, these messages typically lack information about the hazard that will endanger people. In this study, we examine how naming the hazard and its associated cues in a Wireless Emergency Alert influences people’s perceptions that help them make protective action decisions, including understanding, belief, personalization, deciding, response efficacy, and self-efficacy. We also measure the extent to which naming the hazard and its cues affects an organization’s reputation and perceived transparency. To do so, we conduct a 2 (message type: named hazard vs. unnamed hazard) × 3 (hazard type: …

Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković

Administration and Staff Articles and Research

Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …

2025 Hillsborough County Agricultural Fair 4-H Animal Shows, Carrie A. Finke

UNH Cooperative Extension

No abstract provided.

One Health Integration To Control And Prevent Zoonoses: Application Of Organizational Theory Literature, Lisset M. Dumet Poma, Sherril Gelmon, Julia M. Goodman, Seth E. O’Neal

Hatfield Graduate Journal of Public Affairs

Zoonoses are infectious diseases transmitted between animals and people that disproportionately affect low- and middle-income countries (LMICs). The One Health (OH) approach aims to integrate systems, incentivizing collaboration among animal, human, and environmental systems to address zoonoses and improve health. Innovative solutions for effectively and sustainably achieving systems integration are needed. Organizational theories can facilitate the study of the context of OH implementation, applying comprehensive approaches that recognize the interconnections among organisms, the environment, and social systems, including the diverse entities needing integration (e.g., policy, community, public organizations). This narrative review examines organization and systems literature to provide recommendations for …

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests And Lateral Flow Urine Lipoarabinomannan Assays To Detect Tuberculosis Disease In Adults And Adolescents Living With Hiv, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, Ruvandhi R Nathavitharana, Tobias Broger, Ioana Diana Olaru, Brittney Sweetser, Hayley Poore, Alia Razid, Alexander W Kay, Claudia M Denkinger, Ian Schiller, Nandini Dendukuri, Devan Jaganath, Andreas Lundh, Maunank Shah

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular World Health Organization (WHO)-recommended rapid diagnostic tests (also known as mWRDs) widely used to diagnose tuberculosis disease. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended by the WHO to assist in diagnosing tuberculosis disease amongst people with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM used in isolation for the detection of tuberculosis, but in clinical practice the tests may be used in parallel (i.e. LC-aNAAT in combination with LF-LAM).

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory …