Digital Commons Network^™

Amoxicillin Vs Ceftriaxone To Treat Pneumonia Caused By Amoxicillin-Non-Susceptible Streptococcus Pneumoniae, Daniel M Musher

Faculty, Staff and Students Publications

Although the article by J Càmara, I Grau, A González-Díaz, N Santos, et al. (Antimicrob Agents Chemother 69:e00237-25, 2025, https://doi.org/10.1128/aac.00237-25) suggests that ceftriaxone is greatly superior to amoxicillin in treating pneumonia due to pneumococci with an MIC > 2 mg/L, much of the difference in efficacy of the two drugs may have been due to dosage, route, and times of administration of the amoxicillin.

Handling Hemolytic Blood Samples From High-Risk Clinical Areas: A Call To Action, Alan H B Wu, Jerrold H Levy, W Franklin Peacock, Ramzy Rimawi, Manuel Sanchez Luna, Christopher Farnsworth, Hugo Stiegler, Robert H Christenson

2020-Current year OA Pubs

BACKGROUND: Spectrophotometric testing to detect sample hemolysis is available from central laboratory chemistry analyzers. While the cause and preventative measures are known, hemolysis continues to be a common preanalytical error, especially for specimens collected from the emergency department (ED) and intensive care units (ICUs) where point-of-care analyzers are commonly used for whole blood electrolyte testing. Recently, these analyzers have employed technology to detect hemolysis directly on whole blood samples.

METHODS: Experienced laboratorians and physicians from the clinical laboratory, ED, adult and neonatal ICUs provide a summary of the medical importance of in vitro hemolysis. Causes for in vivo hemolysis are …

Population Pharmacokinetics Of Vancomycin And Dose Optimization In Pediatric Patients With Sepsis Or Septic Shock, Nuntapong Boonrit, Thitima Wattanavijitkul, Preecha Montakantikul, Kamolwish Laoprasopwattana, Sutthiporn Pattharachayakul

Journal of Pediatric Infectious Diseases

Objectives: This study aimed to develop a population pharmacokinetic model for vancomycin in pediatric patients with sepsis or septic shock and to propose tailored initial dose recommendations based on the model’s findings. Methods: We conducted a retrospective analysis of pediatric patients with sepsis or septic shock who received vancomycin treatment from January 2017 to December 2019. A population pharmacokinetic model was developed using NONMEM. Monte Carlo Simulations were performed using Crystal Ball software to determine the probability of target attainment (PTA) for different vancomycin dosage regimens based on the target PK/PD index of AUC24hr/MIC > 400 Results: Analyzing 580 vancomycin concentrations …

Is Measles Particularly Hazardous In Cases Of Trisomy 21?, Nihal Akçay, Demet Tosun, İlyas Bingöl

Journal of Pediatric Infectious Diseases

Measles-associated hemophagocytic lymphohistiocytosis is a rare and life-threatening condition, particularly in immunocompromised individuals. This case report discusses the management and successful treatment of a 21-month-old unvaccinated male with Down syndrome who developed secondary Hemophagocytic lymphohistiocytosis during follow-up for pneumonia and respiratory failure. The patient presented with rashes, fever, and cough. Despite initial treatment for pneumonia, he developed respiratory failure, requiring transfer to the pediatric intensive care unit. Physical examination revealed a toxic appearance, bilateral coarse crackles, hepatosplenomegaly, and several mobile cervical lymphadenopathies. Laboratory findings included pancytopenia, hypofibrinogenemia, elevated liver enzymes, and high C-reactive protein. Due to suspicion of myocarditis, intravenous …

Effect Of Covid-19 Pandemic Measures On Streptococcus Pyogenes (Gas) Incidence: 2018-2023 Period Analysis, Ismail Selçuk Aygar, Ahmet Bolat, Kemal Tekin

Journal of Pediatric Infectious Diseases

Objective: Streptococcus pyogenes, or Group A Streptococcus (GAS), can cause mild infections like pharyngitis and impetigo, as well as severe diseases such as necrotizing fasciitis and sepsis. Transmission typically occurs through droplets or direct contact, particularly in children and adolescents, with peaks during winter and spring. In late 2022, the UK reported a sharp increase in GAS cases, with 24 children under 10 dying from the infection. Other European countries also saw a rise in GAS cases, thought to be due to the removal of COVID-19 restrictions like mask-wearing and school closures. The primary objective of this study is twofold: …

Evaluation Of The Treatment Efficacy Of Ivig And Pentaglobin In Neonates With Septic Shock: A Single-Center Retrospective Study, Harun Kizilay, Cengizhan Ceylan, Seyma Tetik-Rama, Rumeysa Demir, Murat Konak, Saime Sundus Uygun, Hanifi Soylu

Journal of Pediatric Infectious Diseases

Objective: This study aimed to evaluate the effects of immunoglobulin use on clinical treatment outcomes, prognosis, and laboratory parameters in neonates with septic shock. Methods: In the study, 155 newborns treated in the Neonatal Intensive Care Unit of Selcuk University Faculty of Medicine between 2019 and 2024 were retrospectively analyzed. Newborns were divided into three groups: those receiving IgM-enriched IVIG (pentaglobin®) treatment, those receiving standard IVIG treatment containing only IgG, and those receiving no immunoglobulin treatment. Laboratory parameters and clinical outcomes were compared and statistically analyzed before and after treatment. Results: Of 155 newborns, 71 (45.8%) were female and 84 …

Comparison Of Hepcidin-25 And Angiogenin (Rnase-5) Levels In Healthy Children And Children With Brucellosis, Ümmü Seleme Mumcu, Özge Metin Akcan, Mehmet Özdemir, Gökçe Kader Arslan, Mustafa Gençeli

Journal of Pediatric Infectious Diseases

Objective: The aim of this study is to determine whether there is a change in serum levels of the anti-microbial peptides Hepcidin-25 and angiogenin, in pediatric patients with Brucellosis compared to healthy controls. In addition, to evaluate their role in brucellosis and relationship with complications of brucellosis. Methods: In our study, children aged 3 to 18 years were included. There were 50 patients in the brucellosis group and 40 healthy children in the control group. Serum hepcidin-25 and angiogenin levels were studied, as well as complete blood count, alanine aminotransferase, aspartate aminotransferas, C-reactive protein, erythrocyte sedimentation rate. The relationship between …

Evaluation Of Kl-6 And Srage As Alveolar Damage Markers In Pediatric Covid-19 Cases: Is Srage The Key Reason For Clinical Differences In Pediatric And Adult Covid-19 Patients?, Gulsen Akkoc, Berker Okay, Sukran Ozdatli Kurtulus, Halil Ugur Hatipoglu, Eda Dilara Bay, Derya Buyukkayhan

Journal of Pediatric Infectious Diseases

Objective: KL-6 and sRAGE, produced by pneumocytes, are novel biomarkers for pulmonary diseases. These markers were found to be elevated in COVID-19 adult patients. The aim of this study was to identify a possible inflammatory biomarker for COVID-19 in children and evaluate these biomarkers to predict clinical course. Methods: Between 01.01.2021 and 31.12.2021, 61 patients (mild and moderate) and 27 control participants aged from 1 month to 18 years were included in the study, and a nonrandomized prospective case-control study was designed. KL-6 and sRAGE levels were evaluated in all participants and compared between each group. Results: The mean age …

Ezrin And Childhood Pneumonia: A Potential Marker Of Pulmonary Epithelial Damage And Inflammation, Sedef Turk, Bahadir M. Samur, Humeyra Aslaner, Didem Barlak-Keti, Emrah Turk, Mehmet Kose

Journal of Pediatric Infectious Diseases

Objective: Ezrin, also known as villin-2 or cytovillin, is a cytoplasmic peripheral membrane protein encoded in humans with the potential implications for various human cancers, cytokine modulation, cytoskeleton remodeling, mucous membrane integrity, and epithelial or pulmonary damage. This study hypothesizes that the amounts of exosome-associated ezrin in the serum detected by ELISA may correlate with the diagnosis or severity of pneumonia in children. We aimed to examine ezrin levels as a pulmonary epithelial cell damage or inflammation marker in a clinical model of pediatric pneumonia. Methods: The prospective study was conducted with 108 previously diagnosed children with pneumonia and 59 …

Ene 661 -101: Environmental Microbiology, Wen Zhang

Civil and Environmental Engineering Syllabi

No abstract provided.

Enhancing The Care Of Patients With Bone And Joint Infections Through Educational Interventions, Neel B. Shah, Jessica Seidelman, Katherine Belden, Elizabeth Thottacherry, Allison Lastinger, Priya Nori, Ronald M. Beaulieu, Don Bambino Geno Tai

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Musculoskeletal infections represent a significant proportion of the clinical workload for infectious diseases (ID) providers, often presenting complex diagnostic and therapeutic challenges. Many providers may feel inadequately prepared to manage these conditions, which require a nuanced understanding of microbiology, musculoskeletal anatomy, surgical intervention, and orthopedic hardware. We implemented a pair of educational interventions including an online library of high-yield musculoskeletal ID literature and an educational podcast. © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Synthetic Plasmodium Antigens, Compositions, And Uses Thereof, John H. Adams, Christopher L. King, Niraj H. Tolia, Edwin Chen, Nichole Diane Salinas, Miriam Thankam George, Francis B. Ntumngia, Samantha Jones Barnes

USF Patents

Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.

Clinical Testing For Covid-19, Influenza, And Rsv In Hospitalized Youths, 2016-2024., Ariana P. Toepfer, Rachel E. Rutkowski, Leila C. Sahni, Geoffrey A. Weinberg, Marian G. Michaels, Rangaraj Selvarangan, Mary Allen Staat, Natasha Halasa, Janet A. Englund, Julie A. Boom, Peter G. Szilagyi, Jennifer E. Schuster, Elizabeth P P. Schlaudecker, Laura S. Stewart, Eileen J. Klein, Samantha M. Olson, Sascha Ellington, Meredith L. Mcmorrow, Heidi L. Moline, Fatimah S. Dawood, New Vaccine Surveillance Network Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Studies of COVID-19, influenza, and respiratory syncytial virus (RSV) disease clinical epidemiology, disease burden, and vaccine effectiveness often rely on clinical testing to identify cases, particularly with increasing use of electronic health record data. However, few data are available describing clinical testing practices to inform interpretation of these studies.

OBJECTIVE: To characterize clinical testing frequency for SARS-CoV-2, influenza, and RSV among children and adolescents hospitalized with acute respiratory illness during the 2016 to 2024 respiratory illness seasons by age, intensive care unit admission, and time period (2016-2020 and each season in 2020-2024); estimate the case fraction missed by clinical …

Gellan Gum Formulations Containing Natural Polyphenolic Compounds To Treat Oral Candidiasis, Narchonai Ganesan, Lewis Oscar Felix, Biswajit Mishra, Liyang Zhang, Charilaos Dellis, Fadi Shehadeh, Danielle Wu, Lissette A Cruz, R M Arce, Eleftherios Mylonakis

Faculty, Staff and Student Publications

Oral candidiasis (OC) is caused by Candida albicans, targeting immunocompromised individuals and developing drug resistance, highlighting the need for advanced therapeutics. Polyphenols such as caffeic acid phenethyl ester (CAPE) and ellagic acid (EA) display antifungal and immune-modulating properties. Incorporating CAPE and EA in gellan gum (GG) formulation enhances their applicability and effectiveness against OC. We developed GG-based formulations loaded with CAPE (1,000 µg/mL), EA (1,000 µg/mL), or CAPE + EA (1,000 µg/mL each) against C. albicans. GG formulations containing gellan (0.6% and 1.0%), genipin (5 mM), polyethylene glycol 400 (0.5%), and sorbitan monooleate 80 (0.5%) demonstrated enhanced release …

Scenario Projections Of Covid-19 Burden In The Us, 2024-2025, Sara L Loo, Sung-Mok Jung, Lucie Contamin, Emily Howerton, Samantha J Bents, Harry Hochheiser, Michael C Runge, Claire P Smith, Erica C Carcelén, Katie Yan, Joseph C Lemaitre, Emily Przykucki, Clifton D Mckee, Koji Sato, Allison L Hill, Matteo Chinazzi, Jessica T Davis, Clara Bay, Alessandro Vespignani, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Sean M Moore, T Alex Perkins, Ajitesh Srivastava, Majd Al Aawar, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Spencer J Fox, Lauren Ancel Meyers, Przemyslaw Porebski, Srinivasan Venkatramanan, Bryan Lewis, Jiangzhuo Chen, Madhav Marathe, Michal Ben-Nun, James Turtle, Pete Riley, Katriona Shea, Cécile Viboud, Justin Lessler, Shaun Truelove

Faculty, Staff and Student Publications

Importance: COVID-19 remains a disease with high burden in the US, prompting continued debate about optimal targets for annual vaccination.

Objective: To project COVID-19 burden in the US for April 2024 to April 2025 under 6 scenarios of immune escape (20% and 50% per year) and levels of vaccine recommendation (no recommendation, vaccination for individuals at high risk only, vaccination for all eligible groups) and to assess the potential benefit of vaccine recommendations in reducing disease burden.

Design, setting, and participants: For this decision analytical model, the US Scenario Modeling Hub, a collaborative modeling effort, convened 9 teams to provide …

Risk Of Cardiovascular Events During Delivery Hospitalization Among Pregnant Patients With Mental Health Conditions, Kavya Parekh, R J Waken, Khavya Avula, Katelin B Nickel, Kathryn J Lindley, Cynthia Rogers, Karen E Joynt Maddox

2020-Current year OA Pubs

BACKGROUND: Cardiovascular disease remains the leading cause of maternal mortality. Mental health disorders are risk factors for cardiovascular disease in nonpregnant populations, but their association with delivery outcomes is unknown.

METHODS: This cross-sectional study used delivery hospitalizations from the 2021 National Inpatient Sample. We used generalized estimating equations to fit quasi-Poisson regression models for cardiovascular severe maternal morbidity and mortality (SMM) events as defined by the Centers for Disease Control and Prevention, and non-SMM cardiovascular conditions or complications as defined by the Alliance for Innovation on Maternal Health. Incidence rate ratios were calculated for depression, anxiety, psychosis, bipolar, obsessive-compulsive disorder, …

Encapsulation Of Disease-Causing And Commensal Mitis Group Non-Pneumococcal Streptococci, Daniel M Musher, Mathias Müsken, M John Hicks, Lesley Mcgee, Bernard Beall

Faculty, Staff and Students Publications

Background: Mitis group non-pneumococcal streptococci (MGNPS), specifically Streptococcus mitis, Streptococcus infantis and Streptococcus oralis, have recently been shown to cause pneumonia and/or bacteremia. These organisms often have capsular (cps) operons resembling those in pneumococci, and some express cps-generated polysaccharides that antigenically cross-react with pneumococcal capsular serotypes. But, to date, a series of MGNPS isolates has not been studied by electron microscopy (EM) for the presence of a capsule.

Methods: We studied 21 MGNPS; 11 were isolated from sputum and determined to have caused pneumonia, 3 were isolated from blood, and 7 were commensal isolates cultured …

Gw Ophthalmology On-Call: 09/2025, Mike Nguyen, Sophie Gorup

GW Ophthalmology On-Call

No abstract provided.

Hist 213-011: The 20th Century World, Elektra Kostopoulou

History Syllabi

No abstract provided.

Math 374-001: Stochastic/Discrete Bio Models, J. Maclaurin

Mathematical Sciences Syllabi

No abstract provided.

Prosthetics In The Time Of Proust, Ashley S. Mcguire

Patent Coloring Books

Patent coloring book

Association Of Covid-19 Status With Maternal And Neonatal Outcomes Among Pregnant Women At Mombasa County Referral Hospital, Kenya, Salome Mghoi Rajab

MSc in Advanced Practice Midwifery

Background: COVID-19 pandemic has raised global concern regarding maternal and neonatal health owing to physiological and immunological changes that may heighten disease severity. Despite the global evidence linking COVID-19 infection with unfavorable pregnancy outcomes, data from Sub-Saharan Africa remain limited. This leaves an essential vacuum in our understanding of how COVID-19 status affects maternal and neonatal outcomes in counties like Mombasa, where health-care system problems may alter risks. Vertical transmission remains a puzzle to be solved.

Aim: To assess the association of COVID-19 status on maternal and neonatal outcomes between March 2020 to March 2022.

Methodology: A …

Private Functional Wildlife Trusts, Stuart W. Babcock

ACTEC Law Journal

Public wildlife law is clear: wild animals exist and are managed for the public writ large. This is a mistake. Wild animals are beings of moral concern; their lives can be good or bad, better or worse, and they should be treated accordingly. This article explores a novel legal instrument which can account for wild animals' unique interests and circumstances: private wildlife trusts, in which wild animals are the trust beneficiaries. Wildlife trusts pose distinctive management and implementation challenges. This article aims to provide a path forward for wildlife advocates seeking new tools to protect wild animals and the habitats …

Are Ai-Assisted Drug Technologies Addressing Or Aggravating The Opioid Crisis In The United States?, Abby O'Hern

West Virginia Law Review

The opioid crisis is a significant public health emergency, intensified by the rise of synthetic opioids such as fentanyl. Lawmakers have described fentanyl as “terroristic in nature” due to its often-fatal properties. According to the Center for Disease Control (“CDC”), an estimated 107,543 people died from drug overdoses in the United States in 2023. As fentanyl use has surged, it has increasingly shaped public health policy through harm reduction initiatives, expanded addiction treatment resources, and legislative reforms aimed at curbing overdose deaths. Artificial Intelligence (“AI”) now plays a dual role in this evolving crisis. While AI technologies offer valuable tools …

Hist 213-015: The 20th Century World, Elektra Kostopoulou

History Syllabi

No abstract provided.

Towards Accessibility In Healthcare For Individuals With And Without Hearing Loss: Evaluation Of Usability, Fit, And Communicative Effectiveness Of A Transparent N95 Mask Prototype, Samuel R. Atcherson, Brooklyn Schultes, Jeanne Hahne, Barbara Debaun, Chris Showell

JADARA

The COVID-19 pandemic has underscored the necessity of effective face masks in both public and healthcare settings for mitigating the spread of disease. However, traditional face masks impede communication, posing significant challenges for approximately 13% of the general population and 10% of healthcare and social assistance workers who have hearing loss and who rely on lipreading and other non-verbal cues. Traditional surgical masks and N95 respirator masks serve important roles in healthcare, but they differ in levels of protection. Currently, a transparent surgical mask is available, but not an N95 version. Thus, this study aimed to evaluate the usability, fit, …

Inborn Errors Of Immunity: Manifestation, Treatment, And Outcome-An Esid Registry 1994-2024 Report On 30,628 Patients., Gerhard Kindle, Mickaël Alligon, Michael H Albert, Matthew Buckland, J David Edgar, Benjamin Gathmann, Sujal Ghosh, Antonios Gkantaras, Alexandra Nieters, Claudio Pignata, Peter N Robinson, Stephan Rusch, Catharina Schuetz, Svetlana Sharapova, Benjamin Shillitoe, Fabio Candotti, Andrew J Cant, Jean-Laurent Casanova, Amos Etzioni, Alain Fischer, Isabelle Meyts, Luigi D Notarangelo, Martine Pergent, C I Edvard Smith, Esid Registry Working Party, Lennart Hammarström, Bodo Grimbacher, Mikko R J Seppänen, Nizar Mahlaoui, Stephan Ehl, Markus G Seidel

Faculty Research 2025

The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world's largest databases on inborn errors of immunity (IEI). IEI are genetic disorders predisposing patients to infections, autoimmunity, inflammation, allergies, and malignancies. Treatments include antimicrobial therapy, immunoglobulin replacement, immune modulation, stem cell transplantation, and gene therapy. Data from 194 centers in 33 countries capture clinical manifestations and treatments from birth onward, with annually expected updates. This report reviews the ESID-R's structure, data content, and impact. The registry includes 30,628 patient datasets (aged 0-97.9 years; median follow-up: 7.2 years; total 825,568.2 patient-years), with 13,550 cases in …

Florida Ems Voices: What Agency Providers Told Us In 2025, Michael Lozano

Florida Center for Emergency Medical Services Research Reports

The 2025 Annual Florida EMS Provider Survey provides a comprehensive overview of Florida’s EMS system, highlighting critical insights into workforce dynamics, resource allocation, medical direction, and service integration across EMS agencies statewide. Conducted from April to May 2025, the survey received robust participation from 249 agencies, covering 74.5% of licensed EMS providers. Key findings underscore regional variability in workforce recruitment, salary scales, mental health support, mobile integrated healthcare (MIH), and preparedness for mass casualty incidents.

Key areas of strategic emphasis include EMT and paramedic mental health and wellness, mobile integrated healthcare (MIH), and local quality improvement (QI) efforts. Notably, recruitment …

Icipe Monthly Digest – Volume 1, Issue 9, September 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Newsletters

No abstract provided.

Summer 2025, Humayun Islam

PMI Newsletter

No abstract provided.