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Use Of Diatomaceous Earth And Copper Oxide Wire Particles To Control Gastrointestinal Nematodes In Lambs, Olivia Jones

Animal Science Undergraduate Honors Theses

Abstract

Anthelmintic resistance (AR) urges alternatives to control gastrointestinal nematodes (GIN). Copper oxide wire particles (COWP) are more efficacious when used with other dewormers and little is known on efficacy of diatomaceous earth (DE) to control gastrointestinal parasites. The objective was to examine the effects of DE and COWP on GIN control. Katahdin lambs (n = 32; ~150 d of age; 25.0 ± 1.8 kg) were randomly assigned to receive: 1) DE fed at an estimated 2% dry matter intake (with the assumption of moderate consumption of bermudagrass forage and provided supplement), 2) 1g COWP, 3) both 2% DE and …

Effect Of Zelnate Administered As A Metaphylactic Upon Initial Processing Of High-Risk, Newly Received Beef Calves On Performance And Morbidity, Brady Martin

Animal Science Undergraduate Honors Theses

Bovine Respiratory Disease (BRD) is the most prominent and costly ailment in the stocker cattle industry today, and its prevalence has not been diminished in the last thirty years. Therefore, the objective of this study was to investigate the effects of Zelnate, a DNA immunostimulant, administered upon arrival to calves (n = 261; BW 253 ± 4.0 kg), on morbidity/mortality, performance and producer costs. Crossbred male beef calves were acquired and transported to the University of Arkansas stocker unit for a 42-d backgrounding period. Calves were allocated into treatment groups: 1) Zelnate, DNA immunostimulant administered or 2) Control, in which …

Implementation Of An Evidence-Based Guideline To Improve Knowledge And Prescribing For Rhinosinusitis, Gerlana Vargas

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

This study measured the effectiveness of an evidence-based guideline intervention regarding provider’s and antibiotic use in a rural health clinic. Sixty percent of providers in the clinic participated in the study. The Antibiotic Knowledge Survey (AKS) was used to measure provider’s knowledge of antibiotic overuse at baseline and 10 weeks post-intervention. Antibiotics prescribed with the diagnosis of sinusitis was measured 6 months pre-intervention and 6 months post-intervention. There was not a significant change in provider’s knowledge from pre-intervention to post-intervention (77.2, SD 9.4), t(16) = 0.63, p = 0.53. However, antibiotic prescribing did decrease from pre- to post-intervention, though …

Quantification Of Mammalian Circadian Rhythms In Response To Photopollution With A Focus On Splitting Behavior, Mehdi Khan

University Honors Program Senior Projects

Circadian rhythms are generated by internal biological clocks of organisms and are responsible for the synchronization of an organism’s external and internal environment. The cells responsible for conducting and maintaining the circadian system are known to be coupled in order to maintain a harmonic rhythm. Desynchronization of the master circadian rhythm can cause the presence of two or more rhythms to emerge in a single organism, also known as splitting behavior. Photopollution and artificial light is known to disrupt this synchronization and result in a desynchronized or split rhythm. Many studies have highlighted that photopollution can disrupt the biological clock …

Response To Phototaxic Stimulation In Relation To Sex And Reproductive State In The Urban Adapted Mosquito, Culex Pipiens F. Molestus, Karen M. Catalina

Theses, Dissertations and Culminating Projects

The mosquito, Culex pipiens f. molestus, is a scientifically relevant species due to its impact upon both human and veterinary medicine. This city dwelling disease vector lives and reproduces in underground tunnels and sewer systems throughout the world. After reproducing, adults begin searching for food above ground, but little is known about the sensory signals that guide this seeking behavior. Because cues may have a major impact on feeding and reproduction, I compared the phototaxic response of adult male and female Cx. pipiens f. molestus at different reproductive states. Virgin females, mated females, virgin males, and mated males were monitored …

Control Of Secondary Extinctions In Stochastic Food Webs, Dunia M. Fernandez

Theses, Dissertations and Culminating Projects

Studies on both model-based and empirical food webs have shown that per- turbations to an ecological community can cause a species to go extinct, often resulting in the loss of additional species in a cascade of secondary extinctions. These eects can seriously debilitate a food web and threaten the existence of an ecosystem. Here, we consider niche model-based food webs with internal noise and investigate the eects of a control on a secondary extinction cas- cade triggered by a noise-induced extinction. We show that the forced removal of a nonbasal species immediately after a primary extinction can extend the mean …

Contrasting Seasonal Presence Of West Nile Virus In Mosquitos Between Coastal And Inland Communities Of New Jersey, Domenica Mousa

Theses, Dissertations and Culminating Projects

In 1999, West Nile Virus (WNV) was introduced to New York City, most likely by an infected bird or mosquito. Since then, West Nile has been detected in every one of the forty-eight continental states of the US, and outbreaks have occurred yearly. Mosquitos play an important role as the main vector for WNV transmission to mammals, birds and some reptiles. As New Jersey is the most densely populated state in the United States, WNV is an ever-present public health concern. High human population density may increase the probability of coming in contact with a WNV positive mosquito. The prevalence …

The Antiviral Effects Of Embelin On Hsv-1 In Cultured Vero Cells, Tony Elias

Theses, Dissertations and Culminating Projects

Herpes simplex virus type 1 (HSV-1) is a linear double stranded DNA virus that is responsible for one of the most common sexually transmitted diseases within the United States. However, treatment drugs for HSV-1 could be costly and may have side effects. In recent years the number of cases of drug resistant HSV-1 has increased, resulting in interest for novel treatments. This study aimed to investigate the antiviral effects of the reagent Embelin on HSV-1 infection in cultured Vero Cells. Embelin is a benzoquinone isolated from the plant Embelia ribes. Cell viability and cell proliferation assays were conducted to determine …

Community Health Nursing In Ghana: Respiratory Illnesses, Paige Deffenbaugh

The Eleanor Mann School of Nursing Undergraduate Honors Theses

As part of a service learning experience, I researched unique risk factors for developing respiratory illnesses in Ghana, Africa. Then, during a study abroad trip to Ghana, I taught groups of women about their high likelihood of exposure to indoor air pollution from solid fuels, how it contributes to the development of respiratory illnesses, and ways to minimize their smoke exposure. All of this education was done with the aim of preventing the development of respiratory illnesses in people of Ghana, as well as minimizing the number of premature deaths attributable to indoor air pollution from solid fuels.

Small Universe: Exploring Microorganisms In Water From An Artistic Perspective, Jingying Zhen

Master's Theses

The scope of this thesis was based on an artistic desire to explore and display microorganisms in water and present the viewers with an opportunity to discover an invisible world. This included research on three artists who have taken interest in unusual life forms. It also included my observation of real microorganisms under a microscope in biology lab. I found the beauty within the details of this miniature world; it was a different perspective. The purpose of this study was to combine biology and art, traveling in the real and imaginary world, researching, exploring, and then showing microorganisms using multiple …

Fatty Acid Mediated Alterations In Biofilm Formation With Vibrio Cholerae, Isabel Gray

Honors Theses

Vibrio cholerae is a Gram-negative bacterium known as a waterborne pathogen. It is often found in marine conditions and can infect humans through ingestion. V. cholerae is responsible for cholera, a disease characterized by profuse diarrhea, vomiting, and other dehydration symptoms. Ultimately, severe cases can cause extreme electrolyte imbalances, shock, and acute renal failure which lead to death in a short period of time. Annually, V. cholerae causes approximately 3 million cases of cholera and 100,000 deaths worldwide. V. cholerae can persist in motile and biofilm lifestyles under aquatic and host conditions, a unique biphasic lifestyle that contributes to Vibrio’s …

Filifactor Alocis: Resilience And Manipulation Against Neutrophil Effector Functions In A Dysbiotic Oral Environment., Max N. Rogers

College of Arts & Sciences Senior Theses

Periodontitis is a multifactorial chronic inflammatory infectious disease that affects around 50% of the adult population in the USA. Neutrophils, which are the primary immune cells recruited to restore health at sites of infection, are profuse in the gingival space during oral infections. In a community-wide effort, pathogenic oral bacteria hijack neutrophil effector functions to evade killing, resulting in an uncontrollable inflammatory loop that leads into inflammation-mediated tissue injury. One of these harmful emerging oral pathogens, Filifactor alocis, has been shown to evade neutrophil killing and contribute to disease progression. The purpose of this study is to gain a …

Barriers To The Implementation Of Telehealth In Rural Communities And Potential Solutions, Mariana Barreiro, Ashley Coles, Caris Conradt, Emma Hales, Elizabeth Zellmer

Anna Vaughn School of Nursing Undergraduate Work

Telehealth is an ever-growing health care system, providing health services from a distance. Telehealth provides medical care through teletechnologies and two-way video and audio communication to connect doctors to patients. A detailed review was created to show the barriers and interventions of implementing a telehealth program in a rural area. The overall purpose of the systematic review was to find and explore relevant research and answer the question, “What are commonly encountered barriers to implementing telehealth in rural areas and what interventions can nurses implement to overcome these barriers?” The approach used to obtain quality data and research was convenience …

Assessing The Effect Of Bile And Oxygen Availability On The Redox Status Of Listeria Monocytogenes Strain F2365, Sukriti Bhattarai

Honors Theses

Although bile is a bactericidal agent able to disrupt membrane structure and cellular homeostasis, including the induction of oxidative stress, Listeria can tolerate bile and also utilize it as a signal to enhance infection and virulence. Preliminary findings showed that under anaerobic conditions, exposure to bile significantly lowered the amount of oxidative damage present in bile-resistant strain F2365 cells. Similarly, Listeria further elicits an adaptive immune response, wherein pre-exposure of the bacterium to stress during food processing or in the host prior to entry into the intestine increases bile tolerance. Based on these previous studies, we hypothesized that bile induces …

Generating Zika Vaccine Candidates Using Nhumirim Virus As A Backbone, Mariam A. Atobiloye

Honors Theses

Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is causing significant world-wide health concern. There are currently no treatments or vaccines available for this virus, thus, there is an urgent need to develop a safe and effective vaccine to combat ZIKV infection. Nhumirim virus (NHUV) is also a mosquito-transmitted flavivirus, but it is unable to infect humans and other vertebrate animals, making it an ideal candidate to develop chimeric viral vaccines against other disease-causing flaviviruses, such as ZIKV. In this study, we generated chimeric viruses by replacing envelope (E) gene in the genome of NHUV with ZIKV E gene, which …

Established Adulthood: A New Conception Of Ages 30 To 45, Clare M. Mehta, Jeffrey Jensen Arnett, Carlie G. Palmer, Larry J. Nelson

Faculty Publications

In developed countries, the years from Age 30 to 45 are, for many, the most intense, demanding, and rewarding years of adult life. During this period of the life span most adults must negotiate the intersecting demands of progressing in a chosen career, maintaining an intimate partnership, and caring for children. Successes or difficulties in meeting these simultaneous demands have the potential to profoundly influence the direction of a person's adult life. As such, we believe that it is of critical importance to better understand this developmental period that we call established adulthood. This article provides a new theoretical …

Evaluation Of Anthelmintic Therapies In A Fall Calving Beef Cowherd, Laine Zammit

Graduate Theses and Dissertations

Internal parasitism inevitability prompts economic loss in beef cattle production by decreasing growth performance and reproductive traits. Today, the most widely used class of anthelmintic used to treat parasitism, is the macrocyclic lactone. Many studies have conflicting results on the efficacy of macrocyclic lactones (ML) efficacy against internal parasitism. The objective of this study was to evaluate the effectiveness of moxidectin and eprinomectin, two of the MLs, on cow performance. Multiparous fall calving, crossbred beef cows (n = 106) were allocated randomly to 1 of 3 anthelmintic treatments: 1) Negative control (CON), in which cows did not receive an anthelmintic, …

Functionalizing Nanoparticles With Cafa Protein To Target Bar Peptide For Oral Delivery Applications., Hetal Desai

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis adherence to Streptococcus gordonii may be important for P. gingivalis colonization in the oral cavity. Nanoparticles encapsulating synthetic peptide BAR (BAR-NPs) inhibit P. gingivalis adherence more potently than free BAR. However, BAR-NPs would exhibit low retention in an open flow environment. Hypothesis: Targeting BAR-NPs to the streptococcal surface using CafA protein will enhance their efficacy. Methods: CafA-modified NPs encapsulating BAR were synthesized using double emulsion approach. Surface binding and retention, and release kinetics of BAR from CafA-modified NPs was assessed. Functional inhibition assays were performed using dual a species biofilm. Results: CafA-modified NPs demonstrated specificity of adhesion, …

Tobacco Enhances Bacterial-Induced Periodontal Bone Loss In Mice., Mina Iskander

Electronic Theses and Dissertations

Background: Tobacco smoking is the leading environmental risk factor for periodontal diseases. Delineation of the mechanisms underlying tobacco-induced or exacerbated periodontitis is hampered by the lack of an appropriate and reliable animal model. Hypothesis: We hypothesized that Porphyromonas-gingivalis-infected, cigarette smoke-exposed mice would represent reproducible models of acute (ligature model) and chronic (oral gavage model) tobacco-enhanced periodontitis that reflect multiple aspects of the disease noted in human smokers. Methods: In a chronic oral gavage disease model, Balb/c mice (6-8 weeks, 4 groups of n = 6 per group) were exposed to smoke produced by a Teague-10 smoking machine from 1R6F research …

The Borders Between Us: Analyzing The United States’ Border Policies & Repercussions, Louise De Oliveira

Creative Activity and Research Day - CARD

This poster addresses the United States’ current southern border situation. It begins by analyzing the historical precedent for discrimination against immigrants to provide a background of understanding for the current situation. It then explains how this aided in President Trump’s election and his resolution to curb illegal immigration by reinforcing the southern border. It also analyzes the Trump Administration's zero-tolerance policy that led to family separation and the personal and political effects of the policy. Furthermore, the poster analyzes the executive order that attempted to end family separations. Finally, the poster examines the current state of border conditions and immigration …

Preservation And Utilization Of Wet Brewer's Grains In Diets Of Dairy Heifers, Eric Hatungimana

Doctoral Dissertations

ABSTRACT

PRESERVATION AND UTILIZATION OF WET BREWER’S GRAINS IN DIETS OF DAIRY HEIFERS

By

Eric Hatungimana

University of New Hampshire, May 2020

Three experiments were conducted. The objective of Experiment 1 was 2-fold: 1) to evaluate the effect of storage of wet brewer’s grains (WBG) treated with salt or a commercial preservative (PRES) on yeast and mold growth and in vitro dry matter digestibility (IVDMD) and 2) to evaluate in situ dry matter (DM) and protein digestibility of WBG treated with salt and PRES. Seven treatments were used for objective 1: control (0%), PRES (0.05%, 0.10%, 0.15%); or salt (1.4%, …

Responses Of Bats To White-Nose Syndrome And Implications For Conservation, Meghan Stark

Doctoral Dissertations

The appearance and spread of emerging infectious diseases pose a significant threat to wildlife populations worldwide having resulted in declines far surpassing those in recorded history. White-nose syndrome (WNS), caused by Pseudogymnoascus destructans (Pd), is currently one of the most pervasive wildlife diseases, with devastating impacts on several North American bat species. Since its initial detection in 2006, Pd has spread rapidly across North America and population declines at hibernating sites have been severe; however, mortality rates from WNS vary among species. While environmental conditions in hibernacula may be strong predictors of disease impacts on individual species, variation in susceptibility …

In Vitro Immune Activation By Treponema Pallidum And The Effect On Osteoclastogenesis: First Experimental Step Towards An Integration Between Osteoimmunology And Paleopathology., Emily Ann Rich

College of Arts & Sciences Senior Theses

The presence of pathogens in the human body influences the expression of pro-inflammatory cytokines by activated immune cells. These cytokines, and other factors, regulate osteoclastogenesis and osteoclast activity. Through experimental osteoimmunology, interactions between the inflammatory response and bone cell physiology may provide insight into how immune processes can be translated into the lesions or abnormalities observed in the osteological record. In this research, our objective was to determine if the cytokines produced by activated immune cells increase osteoclastogenesis and osteoclast activity. To evaluate this hypothesis, we used two main protocols, one for immune activation and one for osteoclastogenesis, that utilized …

Teaching In Ghana: Respiratory Illnesses, Rachel Pruitt

The Eleanor Mann School of Nursing Undergraduate Honors Theses

For participants of this teaching project about respiratory illnesses related to smoke, four goals were created. Our first goal was that participants would be able to recognize the health hazards associated with the populations’ current cooking situation using wood stoves. Secondly, participants would be able to verbalize the benefits of utilizing ceramic coal pots for cooking. Another goal was that participants would be able to explain a simple way to protect their family members from smoke exposure and developing respiratory illnesses. Our final goal was that participants would be able to verbalize and/or demonstrate how to use the new ceramic …

Maternal And Newborn Outcomes For Women Living With Hiv In Adapted Group Prenatal Care, Jodi Behr

Dissertations and Theses (Open Access)

Background: For women living with HIV (WLWH), managing HIV and their pregnancy can be challenging. WLWH have been identified at risk for lower adherence to prenatal care, increased maternal HIV Plasma RNA levels, decreased newborn gestational age, and newborn birth weight. Improved outcomes have been found with group prenatal care. Maternal and newborn outcomes for WLWH and their newborns in group prenatal care compared to WLWH and their newborns in individual care have not been evaluated.

Purpose: The aims of this study were to evaluate group differences between WLWH who attended individual prenatal care appointments (IC) compared to WLWH who …

An Assessment Of Outpatient Clinic Room Ventilation Systems And Possible Relationship To Disease Transmission, Kristin G. King

Dissertations and Theses (Open Access)

The delivery of healthcare in the United States is shifting from a largely inpatient model to an outpatient services model, but the physical infrastructure for outpatient clinics or medical offices may not be as robust as inpatient hospitals regarding whole room ventilation requirements. Guidelines for the design of healthcare facilities and national standards for ventilation establish generally acceptable ventilation rates for outpatient clinics, but it is unclear if these standards are actually being integrated into these settings. Published peer reviewed literature indicates that inadequate ventilation rates can be a risk factor in airborne transmission of infectious diseases in outpatient clinics, …

Understanding Factors That Impact Health Behaviors And Access To Healthcare Among Youth Experiencing Homelessness, Kathryn Rosales Gallardo

Dissertations and Theses (Open Access)

Youth experiencing homelessness (YEH) have a high risk of adverse health outcomes and their utilization of healthcare services is low. This dissertation aims to further understand factors that impact YEH’s health behaviors and access to healthcare services. This dissertation is in the form of three manuscripts that each contribute to the overall aim. In manuscript 1, we examined the rates and correlates of human papillomavirus (HPV) vaccination initiation and completion among a sample of YEH in seven U.S. cities using logistic regression models. We found that HPV vaccination completion is low among male (19%) and female (37%) YEH. Among male …

Trends In Injection Drug Use In Texas Treatment Facility Admissions, Cara Dahlhausen

Dissertations and Theses (Open Access)

This is a serial cross-sectional secondary analysis of drug treatment admissions records from the TEDS-A from years 2013-2017. The prevalence of injected drug use was calculated for each year and analyzed across the five-year period using a chi-square test to determine the presence of significant change in injection drug use from 2013 to 2017. Prevalence of injection drug use also will be calculated for each year by drug type (heroin, methamphetamine, and cocaine), age, sex, ethnicity and race, and will be analyzed for trends using a chi-square test.

Exploration Of Breastfeeding As A Protective Factor For Breast Cancer In South African Women: A Nested Case-Control Study, Booker S. Quiera

Dissertations and Theses (Open Access)

Background. South African’s (SA) breast cancer incidence rate is continually increasing (39 per 100,000 (2012) versus 46.2 per 100,000 (2018) with trends towards later-stage diagnosis. In previous literature, breastfeeding has been assessed as a protective factor for breast cancer; however, the SA population experiences inconsistent breastfeeding trends, rates, and support services. Therefore, this study will evaluate the inverse association between breast cancer and breastfeeding history. Methods. Cases (breast cancer) and controls (mastalgia) were matched 1:1 on clinical visit from May-August 2019 at Groote Schuur Hospital (GSH) in Cape Town, Western Cape, South Africa. Breastfeeding history, breast carcinoma diagnosis, and clinically …

Exploration Of Breastfeeding As A Protective Factor For Breast Cancer In South African Women: A Nested Case-Control Study, Quiera S. Booker

Dissertations and Theses (Open Access)

South African’s (SA) breast cancer incidence rate is continually increasing (39 per 100,000 (2012) versus 46.2 per 100,000 (2018) with trends towards later-stage diagnosis. In previous literature, breastfeeding has been assessed as a protective factor for breast cancer; however, the SA population experiences inconsistent breastfeeding trends, rates, and support services. Therefore, this study will evaluate the inverse association between breast cancer and breastfeeding history. Methods. Cases (breast cancer) and controls (mastalgia) were matched 1:1 on clinical visit from May-August 2019 at Groote Schuur Hospital (GSH) in Cape Town, Western Cape, South Africa. Breastfeeding history, breast carcinoma diagnosis, and clinically relevant …