Digital Commons Network^™

Cautionary Tale Of Using Tris(Alkyl)Phosphine Reducing Agents With Nad+-Dependent Enzymes, Sagar M. Patel, Thomas G. Smith, Martha Morton, Kyle M. Stiers, Javier Seravalli, Stephen J. Mayclin, Thomas E. Edwards, John J. Tanner, Donald F. Becker

Department of Biochemistry: Faculty Publications

Protein biochemistry protocols typically include disulfide bond reducing agents to guard against unwanted thiol oxidation and protein aggregation. Commonly used disulfide bond reducing agents include dithiothreitol, β-mercaptoethanol, glutathione, and the tris(alkyl)phosphine compounds tris(2-carboxyethyl)phosphine (TCEP) and tris(3-hydroxypropyl)phosphine (THPP). While studying the catalytic activity of the NAD(P)H-dependent enzyme Δ¹-pyrroline-5-carboxylate reductase, we unexpectedly observed a rapid non-enzymatic chemical reaction between NAD⁺ and the reducing agents TCEP and THPP. The product of the reaction exhibits a maximum ultraviolet absorbance peak at 334 nm and forms with an apparent association rate constant of 231–491 M⁻¹ s⁻¹. The reaction is …

College Of Education News, College Of Education, Georgia Southern University

College of Education: News & Publications (2003-2023)

• College of Education Jack Miller Award winners announced for 2020-21

Volume 56 - Issue 01 - Monday, September 14, 2020, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

2020-09-14_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Can The One Health Approach Save Us From The Emergence And Reemergence Of Infectious Pathogens In The Era Of Climate Change: Implications For Antimicrobial Resistance?, Smitha Gudipati, Marcus J. Zervos, Erica Herc

Infectious Diseases Articles

Climate change has become a controversial topic in today's media despite decades of warnings from climate scientists and has influenced human health significantly with the increasing prevalence of infectious pathogens and contribution to antimicrobial resistance. Elevated temperatures lead to rising sea and carbon dioxide levels, changing environments and interactions between humans and other species. These changes have led to the emergence and reemergence of infectious pathogens that have already developed significant antimicrobial resistance. Although these new infectious pathogens are alarming, we can still reduce the burden of infectious diseases in the era of climate change if we focus on One …

We All Share Responsibility For Keeping Our Campus Healthy, Jean Gispen

University of Mississippi News

No abstract provided.

The Guardian, Week Of September 14, 2020, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 14, 2020. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

2020-09-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Global Scientific Research On Coronavirus : A Scientometric Study, Pooja P. Dadhe, Manju N. Dubey

Library Philosophy and Practice (e-journal)

To understand the global research trend of the scientific publication on coronavirus, this scientometric study was carried out for the period 2002 to 2019 based on scientometric indicators such as growth of publication, productive authors and institutions, collaboration among authors and institutions, the hotspot of research area and the citation pattern. A total of 8541 records downloaded from PubMed formed the dataset for the study and were analysed using Bibexcel and VOSviewer. The findings reveal that the research on coronavirus was noticeable but it was not significant. A correlation between the number of publications and emergence of SARS in 2002 …

Bibliometrics Of Covid-19 Publications In First Three Months Of 2020, Anil Kumar Siwach

Library Philosophy and Practice (e-journal)

The paper is an attempt to analyze the publications on COVID-19, an infectious disease which has been declared a pandemic by WHO. The publications during Jan-March 2020 have been selected for the study that has been indexed in Scopus database till March 31, 2020. It was found that during this span of three months, 884 documents have been published on COVID-19 in the form of articles, news, letters, notes, editorials, reviews, short surveys and erratum. These documents received a total of 2603 citations and six documents received even more than 100 citations. China has contributed maximum documents and Huazhong University …

2020-09-12_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Human Botfly Infestation: Furuncular Myiasis, Rachel Rhee, Christina E. Borchers, Samia Borchers, Gregory Maupin, Jeffery Weinstein

Dermatology Faculty Publications

Dermatobia hominis is one of many species of botflies whose larvae is parasitic to humans and is uniquely indigenous to Central and South America. The larvae of the human botfly gain nutrients to survive by feeding underneath mammal skin. As a consequence, within 24 hours, small 2- 3mm painful, erythematous, draining, and purulent papules with a classical air-pore develop as the initial cutaneous sign. At first, the lesions resemble that of an insect bite, but over time they enlarge to 10-35mm in diameter with a surrounding area of induration. The most common areas where the larvae are cutaneously deposited include …

September 11, 2020: Safe Return To Campus Fall 2020, Update 5, Kettering University

Communication Updates

The COVID-19 Response Team and University leadership continue to closely monitor the local, state and national situation in consultation with health experts and in accordance with government guidelines. If conditions change, the University will alter plans to ensure the safety of the campus community. Fall Term 2020 classes begin on October 5. As the University’s COVID-19 Response Team continues to finalize details for the fall, please carefully review these updates.

2020-09-11_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Proteomic Profiles Of Exosomes Of Septic Patients Presenting To The Emergency Department Compared To Healthy Controls, Daniel C. Morris, Anja K. Jaehne, Michael Chopp, Zhenggang Zhang, Laila M. Poisson, Yalei Chen, Indrani Datta, Emanuel P. Rivers

Emergency Medicine Articles

BACKGROUND: Septic Emergency Department (ED) patients provide a unique opportunity to investigate early sepsis. Recent work focuses on exosomes, nanoparticle-sized lipid vesicles (30-130 nm) that are released into the bloodstream to transfer its contents (RNA, miRNA, DNA, protein) to other cells. Little is known about how early changes related to exosomes may contribute to the dysregulated inflammatory septic response that leads to multi-organ dysfunction. We aimed to evaluate proteomic profiles of plasma derived exosomes obtained from septic ED patients and healthy controls.

METHODS: This is a prospective observational pilot study evaluating a plasma proteomic exosome profile at an urban tertiary …

Artificial Intelligence–Powered Smartphone App To Facilitate Medication Adherence: Protocol For A Human Factors Design Study, Don Roosan, Jay Chok, Mazharul Karim, Anandi V. Law, Andrius Baskys, Angela Hwang, Moom Roosan

Pharmacy Faculty Articles and Research

Background: Medication Guides consisting of crucial interactions and side effects are extensive and complex. Due to the exhaustive information, patients do not retain the necessary medication information, which can result in hospitalizations and medication nonadherence. A gap exists in understanding patients’ cognition of managing complex medication information. However, advancements in technology and artificial intelligence (AI) allow us to understand patient cognitive processes to design an app to better provide important medication information to patients.

Objective: Our objective is to improve the design of an innovative AI- and human factor–based interface that supports patients’ medication information comprehension that could potentially …

Indoline‐6‐Sulfonamide Inhibitors Of The Bacterial Enzyme Dape, Cory T. Reidl, Tahirah K. Heath, Iman Darwish, Rachel M. Torrez, Maxwell Moore, Elliot Gild, Boguslaw P. Nocek, Anna Starus, Richard C. Holz, Daniel P. Becker Ph.D.

Chemistry: Faculty Publications and Other Works

Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide DapE inhibitors from a high-throughput screen and the synthesis of a series of analogs. Inhibitory potency was measured by a ninhydrin-based DapE assay recently developed by our group. Molecular docking experiments suggest active site binding with the sulfonamide acting as a zinc-binding group (ZBG).

Indoline-6-Sulfonamide Inhibitors Of The Bacterial Enzyme Dape, Cory T. Reidl, Tahirah K. Heath, Iman Darwish, Rachel M. Torrez, Maxwell Moore, Elliot Gild, Boguslaw P. Nocek, Anna Starus, Richard C. Holz, Daniel P. Becker Ph.D.

Chemistry: Faculty Publications and Other Works

Inhibitors of the bacterial enzyme dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18) hold promise as antibiotics with a new mechanism of action. Herein we describe the discovery of a new series of indoline sulfonamide DapE inhibitors from a high-throughput screen and the synthesis of a series of analogs. Inhibitory potency was measured by a ninhydrin-based DapE assay recently developed by our group. Molecular docking experiments suggest active site binding with the sulfonamide acting as a zinc-binding group (ZBG).

Pulmonary Langerhans Cell Histiocytosis In The Elderly Smoker, Hafiz Muhammad Jeelani, Hamid Ehsan, Muhammad Mubbashir Sheikh, Adeel Riaz, Hafiz Mahboob

School of Medicine Faculty Research

Langerhans cell histiocytosis (LCH), formally referred to histiocytosis X, is a histiocytic disorder with unknown etiology. The pathogenesis is believed to originate from myeloid dendritic cells and is now considered an inflammatory myeloid neoplasm within the revised 2016 Histiocyte Society classification. Pulmonary Langerhans cell histiocytosis (PLCH) is a rare and isolated form of LCH with a strong affiliation with smoking in adults of 20-40 years of age. Characteristic CT chest and histologic findings are instrumental in the early recognition and management of a disease. We herein report a case of a Caucasian smoker female with a significant history of interstitial …

Effects Of Respiratory Infection Prevention Education For Rural Dwelling Elderly On Kap And Social Capital, Myung Soon Kwon, Jin Soon Kim

International Nursing Research Congress (INRC)

This study was to investigate the effectiveness of respiratory infection prevention(RIP) program based on Social Cognitive Theory developed for rural dwelling elderly on South Korea. In conclusion, it was verified continuous effect on improving the knowledge, attitude, and practice of RIP, and enhances the social capital of the rural elderly.

Chimes: September 11, 2020, Calvin University

Chimes

Academic calendar changes announced, effective next school year by Harm Venhuizen

Local CRC appoints deacon who is in same-sex marriage by Juliana Knot

Three months after George Floyd, Calvin continues to respond to BLM by Katherine Benedict

Students recount their isolation experiences after report symptoms by Abigail Ham

Calvin mourns the loss of rising senior Iris Jones by Harm Venhuizen

Graduation for class of 2020 postponed until April 17, 2021 by Juliana Knot

COVID-19 dashboard help keep Calvin community informed by Lauren Vanden Bosch

SAO to launch "Toknight Show", other tentative events by Susanaah Epp

Celebration Cinema offers "drive-in" alternative …

Home-Modification Interventions Addressing Falls And Participation In Activities Of Daily Living Among Older Adults: A Scoping Review Protocol, Gifty M. Georlee, Abiram Abiram, Pham Ngoc Dat, Nguyen Khac Tuan

Open Access archive

Introduction Falls are the second leading reason for incidental or unexpected deaths worldwide. Many older adults who fall, regardless of whether they are injured or not, tend to experience fear of fall and this can lead to decreased participation in activities of daily living (ADLs). Subsequent falls lead to weakness, a decline in physical functioning, increased chances of falling and a negative impact on the instrumental ADLs. Here, we present our scoping review protocol to appraise the literature to describe and explain the home-modification interventions used by occupational therapists to address falls and participation in ADLs among community-dwelling older adults. …

Covid-19 Hyperinflammation And Post-Covid-19 Illness May Be Rooted In Mast Cell Activation Syndrome, Lawrence B Afrin, Leonard B Weinstock, Gerhard J Molderings

Open Access Publications

OBJECTIVES: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2. Although only recently recognized, MC activation syndrome (MCAS), usually due to acquired MC clonality, is a chronic multisystem disorder with inflammatory and allergic themes, and an estimated prevalence of 17%. This paper describes a novel conjecture explaining how MCAS might cause a propensity for severe acute Covid-19 infection and chronic post-Covid-19 illnesses.

METHODS: Observations of Covid-19 illness in patients with/without MCAS were compared with extensive clinical experience with MCAS.

RESULTS: The prevalence of MCAS is …

Simulating Phase Transitions And Control Measures For Network Epidemics Caused By Infections With Presymptomatic, Asymptomatic, And Symptomatic Stages, Benjamin Braun, Başak Taraktaş, Brian Beckage, Jane Molofsky

Mathematics Faculty Publications

We investigate phase transitions associated with three control methods for epidemics on small world networks. Motivated by the behavior of SARS-CoV-2, we construct a theoretical SIR model of a virus that exhibits presymptomatic, asymptomatic, and symptomatic stages in two possible pathways. Using agent-based simulations on small world networks, we observe phase transitions for epidemic spread related to: 1) Global social distancing with a fixed probability of adherence. 2) Individually initiated social isolation when a threshold number of contacts are infected. 3) Viral shedding rate. The primary driver of total number of infections is the viral shedding rate, with probability of …

Current Scenario Of Covid-19 With Epidemiological And Phylogenetic Analysis Of Pakistani Coronavirus: A Review, Asma Altaf, Wafa Iqbal, Sidra Younis, Farah Deeba

Journal of Bioresource Management

A novel corona virus named as 2019 n-CoV was identified to be the actual cause of an outbreak of respiratory illness in Wuhan, China beginning in late December 2019. This respiratory disease was named as COVID-19 by WHO. There are many countries affected by COVID-19 including Pakistan. In this review we have provided a brief introduction of COVID-19 and discussed epidemiological and phylogenetic analysis of Pakistani novel corona virus strain. Our epidemiological analysis of data till 16^th May 2020 showed rapidly increasing number of new cases, while at the same time a higher recovery rate than number of deaths …

Did You Wash Your Caving Suit? Cavers’ Role In The Potential Spread Of Pseudogymnoascus Destructans, The Causative Agent Of White-Nose Disease, Violeta Zhelyazkova, Antonia Hubancheva, Georgi Radoslavov, Nia Toshkova, Sebastien J. Puechmaille

International Journal of Speleology

White-Nose Disease (WND) has killed millions of hibernating bats in the US and Canada. Its causative agent, the fungus Pseudogymnoascus destructans was introduced to North America, but is native to Europe and Asia, where it is not associated with mass mortality. Although it is nearly impossible to eradicate an emerging wildlife disease, research on P. destructans spread mechanisms can aid in prevention of new introductions and development of better environmental management strategies. It is of particular importance to quantify the potential role of people visiting caves (cavers, tourists, bat researchers, etc.) whom inadvertently move P. destructans spores between sites, and …

2020-09-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Religious Liberty In A Pandemic, Caroline Mala Corbin

Duke Law Journal Online

The coronavirus pandemic caused an unprecedented shutdown of the United States. The stay-at-home orders issued by most states typically banned large gatherings of any kind, including religious services. Churches sued, arguing that these bans violated their religious liberty rights by treating worship services more strictly than analogous activities that were not banned, such as shopping at a liquor store or superstore. This Essay examines these claims, concluding that the constitutionality of the bans turns on the science of how the pathogen spreads, and that the best available scientific evidence supports the mass gathering bans.

Commonwealth Times 2020-09-09

Commonwealth Times, 1969-

No abstract provided.

The Impact Of Appendectomy In Clostridium Difficile Infection And Length Of Hospital Stay., Rajesh Essrani Md, Dany Saturno, Shehriyar Mehershahi, Rajesh Kumar Essrani, Muhammad Rajib Hossain, Shri Jai Kirshan Ravi, Andrea Berger, Asif Mehmood

Department of Emergency Medicine

Introduction We aim to investigate Clostridium difficile infection (CDI) recurrence, severity, complications, and length of hospital stay in patients with and without prior history of appendectomy who were admitted to the hospital with CDI. Method We analyzed retrospective data for 862 patients, 18 years and older, with C. difficile inpatients diagnosed between January 1, 2017 and December 31, 2018 and sorted into two groups, with or without prior appendicectomy, to look for outcomes such as recurrence, hospital stay, complications, and related death in each group and use statistical analysis for comparison. Result There were 862 patients admitted with CDI, of …