Digital Commons Network^™

Two Clinical Prediction Tools To Improve Tuberculosis Contact Investigation, Ruoran Li, Francesco Nordio, Chuan-Chin Huang, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Zibiao Zhang, Mercedes C. Becerra, Leonid Lecca, Megan B. Murray

Social Work Faculty Publications

Background: Efficient contact investigation strategies are needed for the early diagnosis of TB disease and treatment of latent TB infections.

Methods: Between September 2009 and August 2012, we conducted a prospective cohort study in Lima, Peru in which we enrolled and followed 14,044 household contacts of adult pulmonary TB patients. We used information from a subset of this cohort to derive two clinical prediction tools that identify contacts of TB patients at elevated risk of progressing to active disease by training multivariable models that predict (1) co-prevalent TB among all household contacts and (2) one-year incident TB among adult contacts. …

Health Priorities For Sustainable Development, Lisa E. Sachs, Jeffrey D. Sachs

Columbia Center on Sustainable Investment Staff Publications

The right to health has been repeatedly recognized as one of the core human rights, essential for human functioning, human dignity, economic well-being and development. But the right to health continues to elude hundreds of millions and with Covid-19, perhaps billions of people. Poverty remains the most critical obstacle to the realization of the right to health in developing countries. Achieving universal health coverage, before the additional costs of Covid-19, would require roughly $50 billion per year, approximately 0.1 percent of the GDP of the high-income OECD countries. Yet despite this broad understanding of the vicious cycle of poverty and …

Endothelial Cell Contributions To Covid-19, Alexandra E. Oxford, Fabio Halla, Evan B. Robertson, Brad E. Morrison

Biology Faculty Publications and Presentations

Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has remained elusive. Coronavirus disease 2019 (COVID-19) caused by this virus has unusual clinical presentation with regard to other related coronaviruses. Recent reports suggest that SARS-CoV-2, unlike other related viruses, infects and replicates within endothelial cells, which may explain a significant portion of the observed clinical pathology. Likewise, mounting evidence associates vascular and endothelial cell dysfunction with increased mortality. This review focuses on understanding how endothelial cell pathology is caused by SARS-CoV-2 at the molecular and cellular levels and how …

Testing The Motivational Tradeoffs Between Pathogen Avoidance And Status Acquisition, Mitch Brown, Donald F. Sacco

Psychological Science Faculty Publications and Presentations

To reduce disease transmission through interpersonal contact, humans have evolved a behavioral immune system that facilitates identification and avoidance of pathogens. One behavioral strategy in response to pathogenic threat is the adoption of interpersonal reticence. However, reticence may impede status acquisition. This program of research tested whether activating pathogen-avoidant motives through priming fosters reticence related to status, namely disinterest in pursuing a group leadership position (Study 1) or disinterest in accepting a group leadership position bestowed onto them (Study 2). Individuals high in germ aversion were particularly interested in pursuing leadership as a form of status, with disease salience unexpectedly …

The Impact Of Delayed Treatment Of Uncomplicated P. Falciparum Malaria On Progression To Severe Malaria: A Systematic Review And A Pooled Multicenter Individual-Patient Meta-Analysis, Andria Mousa, Abdullah Al-Taiar, Nicholas Anstey, Cyril Badaut, Bridget Barber, Quique Bassat, Joseph Challenger, Aubrey Cunnington, Dibyadyuti Datta, Robert Opoka

Paediatrics and Child Health, East Africa

Background: Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as 'test-and-treat' policies administered by community health workers (CHWs). We conducted a pooled individual-participant meta-analysis to estimate the association between treatment delay and presenting with SM.

Methods and findings: A search using Ovid MEDLINE and …

2020-October-01-Etsu Health Receives Cup Of Kindness Award For Community Service.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

Highlights of Community Service

Early in the pandemic, ETSU Health worked to established the region’s first drive-through COVID-19 testing site. This site was instrumental in detecting the first cases of community spread in the area. Currently, ETSU’s Quillen College of Medicine is conducting vital research on COVID-19 using blood samples from local patients who have recovered from the disease.

As the pandemic progressed, ETSU Health became a go-to source of expertise for government and community leaders, our local media, and the public. Representatives from ETSU Health were called upon for interviews about various facets of COVID-19, and the ETSU College …

Oral Conditions In Hepatitis C Virus‐Infected Egyptian Patients: A Case‐Control Study, Asmaa Ras, Eman Khalil

Dentistry

Introduction: One of the serious public health problems nowadays is the hepatitis C virus (HCV) infection. Hepatitis C virus infection morbidity is associated with a diversity of extrahepatic disorders counting the oral cavity. Some of the oral manifestations are oral diseases like lichen planus and xerostomia and side effects of the virus therapy. The aim of this study was to evaluate and compare the oral health status, of patients with and without virus C in a sample of the Egyptian population.
Methods: Data were collected from the Gastroenterology department at Benha University. The study was designed as a case-control study; …

Experiencing The Transition To Remote Teaching And Learning During The Covid-19 Pandemic, Chun-Hua Tsai, Guillermo Romera Rodriguez, Na Li, Jenay Robert, Alex Serpi, John Millar Carroll

Information Systems and Quantitative Analysis Faculty Publications

The sudden onset of the COVID-19 pandemic severely disrupted universities around the world. In the two weeks following a shelter–in-place order, all the actors of the educational system were forced to transition to remote education. This shift required a new reliance upon technologies that these individuals might never have adopted at all, often with significant difficulties. In this paper, we present a qualitative study on a university-wide survey dataset describing student and faculty experiences of abruptly transitioning to remote teaching and learning during the spring 2020 semester at the Pennsylvania State University. We performed an inductive thematic analysis to identify …

Inspire : Vol 2, Issue 2, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Message from The Chair
• Accelerating the elimination of viral hepatitis:
• a Lancet Gastroenterology & Hepatology Commission
• Peritoneal Dialysis Program by Syed Farrukh Umair
• Department of Medicine at National and International Forums
• What Are Academics Around the World Reading This Month?
• Featured Faculty Profile
• Dr. Saman Ali; “Stay true to yourself, stay humble, work hard but also try to have fun while doing it.”
• Publications

A Baker’S Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2019, Kayla R. Stover, Elias B. Chahine, David Cluck, Sarah Green, Daniel B. Chastain, Darrell Childress, Carmen Faulkner-Fennell, Katherine Lusardi, Edoabasi U. Mcgee, Michelle Turner, P. Brandon Bookstaver, Christopher M. Bland

ETSU Faculty Works

Staying current on literature related to antimicrobial stewardship can be challenging given the ever-increasing number of published articles. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship–related peer-reviewed literature that detailed an actionable intervention for 2019. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training and to identify potential intervention opportunities within one’s institution.

Development And Interim Analysis Of A Cystic Fibrosis-Specific Antibiogram, Claire Elson, Ellen Meier, Douglas Swanson, Rangaraj Selvarangan, Megan Gripka, Christopher M. Oermann

Posters

Antimicrobial therapy is essential to treat cystic fibrosis (CF) lung infections. Empiric antimicrobial selection is generally based on previous culture information and, if available, an institution-specific antibiogram (ABGM). Most institutions antibiograms exclude cultures from individuals with cystic fibrosis, imposing challenges with empiric antimicrobial selection and monitoring susceptibility patterns over time. A cystic fibrosis-specific antibiogram may help drive population-specific antimicrobial selection and improve antimicrobial stewardship.

Fostering Resilience In Correctional Officers, Jon Thomas Arthur Gist

Theses and Dissertations

A significant portion of the literature regarding corrections emphasizes the negative factors and outcomes related to the job. The career of a correctional officer includes a stressful, demanding, and unpredictable work environment. Correctional institutions are struggling to keep a correctional staff that can adapt to internal and external forces. Several studies have shown that correctional officers frequently encounter severe inmate misconduct, resulting in high levels of stress, low job satisfaction, and intentions of leaving the job. However, research begs the question of what makes a correctional officer resilient and functional at work?

No prior study has applied a mixed-methods study …

Maternal Preventive Dental Services Utilization: The Role Of Preconception Oral Health Counseling In And The Association With Birth Outcomes: Evidence From South Carolina Prams, Monique Johnette Williams

Theses and Dissertations

ABSTRACTThe purpose of this study is to examine maternal preventive dental services utilization by analyzing the role of preconception oral health counseling in utilization of dental cleaning services before or during pregnancy and the association of utilization with preterm birth (<37 weeks) and small for gestational age (SGA) (same sex newborns having birth weight for gestational age below the 10th percentile of the reference population as defined by the World Health Organization (WHO)). Studies suggest that unfavorable maternal oral conditions have significance in birth outcomes, specifically periodontal disease (periodontitis), an oral inflammatory condition which is shown to be a risk factor for preterm birth and low birth weight (Dortbudak et al., 2005; Guimarães et al., 2012; Tejada et al., 2012). Dental cleaning before and during pregnancy is effective in the prevention of oral disease including gingivitis and periodontitis (Johnson et al., 2006; Kurien et al., 2013; Steinberg et al., 2013).

Cross-sectional 2012-2015 data from the South Carolina Pregnancy Risk Assessment Monitoring System (SC PRAMS) survey, a population-based surveillance system on prenatal, perinatal and postpartum experiences of resident mothers who recently delivered a live-born infant, were analyzed using weighted analyses in SAS. Analyses included demographic univariate analyses, Rao-Scott Chi-squared tests of significance to study differences between groups, and multivariate logistic …

Spatiotemporal Analysis Of Medical Resource Deficiencies In The U.S. Under Covid-19 Pandemic, Dexuan Sha, Xin Miao, Hai Lan, Kathleen Stewart, Shiyang Ruan, Yifei Tian, Yuyang Tian, Chaowei Yang

College of Natural and Applied Sciences

Coronavirus disease 2019 (COVID-19) was first identified in December 2019 in Wuhan, China as an infectious disease, and has quickly resulted in an ongoing pandemic. A data-driven approach was developed to estimate medical resource deficiencies due to medical burdens at county level during the COVID-19 pandemic. The study duration was mainly from February 15, 2020 to May 1, 2020 in the U.S. Multiple data sources were used to extract local population, hospital beds, critical care staff, COVID-19 confirmed case numbers, and hospitalization data at county level. We estimated the average length of stay from hospitalization data at state level, and …

Implications Of Covid-19 In High Burden Countries For Hiv/Tb: A Systematic Review Of Evidence, Jacques L. Tamuzi, Birhanu T. Ayele, Constance Shumba, Olatunji O. Adetokunboh, Jeannine Uwimana-Nicol, Zelalem T. Haile, Joseph Inugu, Peter S. Nyasulu

School of Nursing & Midwifery, East Africa

Background: The triple burden of COVID-19, tuberculosis and human immunodeficiency virus is one of the major global health challenges of the twenty-first century. In high burden HIV/TB countries, the spread of COVID-19 among people living with HIV is a well-founded concern. A thorough understanding of HIV/TB and COVID-19 pandemics is important as the three diseases interact. This may clarify HIV/TB/COVID-19 as a newly related field. However, several gaps remain in the knowledge of the burden of COVID-19 on patients with TB and HIV. This study was conducted to review different studies on SARS-CoV, MERS-CoV or COVID-19 associated with HIV/TB co-infection …

Both Insider And Outsider: On Conducting Social Work Research In Mental Health Settings, Beth Sapiro, Elizabeth B. Matthews

Department of Social Work and Child Advocacy Faculty Scholarship and Creative Works

The mental health clinic poses unique challenges for social work scholar-practitioners. The familiar setting, the nature of mental health data collection, and the researcher’s clinical training and experience all complicate efforts to maintain a reflexive stance in research. Additionally, conducting research in a clinical environment risks replicating a hierarchical medical model in the research relationship. Using a theoretical framework of critical realism, two doctoral-level scholar practitioners analyzed the advantages and challenges of conducting research in a clinical setting. Audit trails and experiences of peer debriefing from their dissertation research served as the basis for this conceptual analysis. The analysis considers …

High-Quality Nuclear Genome For Sarcoptes Scabiei—A Critical Resource For A Neglected Parasite, Pasi K. Korhonen, Robin B. Gasser, Guangxu Ma, Tao Wang

Open Access archive

The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We …

St09, A Novel Curcumin Derivative, Blocks Cell Migration By Inhibiting Matrix Metalloproteases In Breast Cancer Cells And Inhibits Tumor Progression In Eac Mouse Tumor Models, Snehal Nirgude, Raghunandan Mahadeva, Jinsha Koroth, Sujeet Kumar

Open Access archive

Purpose: Curcumin is known for its anticancer and migrastatic activity in various cancers, including breast cancer. Newer curcumin derivatives are being explored to overcome limitations of curcumin like low bioavailability, stability, and side effects due to its higher dose. In this study, the synthesis of ST09, a novel curcumin derivative, and its antiproliferative, cytotoxic, and migrastatic properties have been explored both in vitro and in vivo. Methods: After ST09 synthesis, anticancer activity was studied by performing standard cytotoxicity assays namely, lactate dehydrogenase (LDH) release assay, 3-(4, 5-dimethylthiazol-2-yl)-2-5-diphenyletrazolium bromide (MTT), and trypan blue exclusion assay. Annexin-FITC, cell cycle analysis using flow …

Proteomics Dataset Of Adult Anopheles Stephensi Female Brain, Gourav Dey, Ajeet Kumar Mohanty, Sreelakshmi K. Sreenivasamurthy, Manish Kumar

Open Access archive

Mosquitoes with their ability to transmit several pathogens of human disease pose a serious threat to healthcare worldwide. Although much has been done to prevent the disease transmission by mosqitos. The rising rate of resistance in mosquitos towards conventionally used control strategies necessitates developing of novel strategies to counter disease transmission. The mosquito brain plays a key role in host-seeking, finding mates and selection of oviposition sites. However, not much is know about the underlying physiological processes in mosquito brain. The data presented in this study describes the proteins that have been identified in the brain tissue of adult female …

New Mexico Health Care Workforce Committee 2020 Annual Report, University Of New Mexico - Health Sciences Center

New Mexico Health Care Workforce Committee (2013-ongoing)

Each year the New Mexico Health Care Workforce Committee studies the supply and distribution of health care providers in order to provide a report to the Legislature by October 1. The committee also makes recommendations for improving recruitment and retention of providers in New Mexico's rural and underserved areas.

Laser Functionalization Of Carbon Membranes For Effective Immobilization Of Antimicrobial Silver Nanoparticles, Sina Nejati, Seyed Ahmad Mirbagheri, Jose Waimin, Marisa E. Grubb, Samuel Peana, David M. Warsinger, Rahim Rahimi

School of Mechanical Engineering Faculty Publications

Microbial contamination and biofilm formation are serious challenges in water filtration applications. Recently, carbon nanocomposite membranes with modified silver nanoparticles (AgNPs) have attracted much attention as compelling water purification membranes that can deactivate pathogenic bacteria and prevent biofilm formation. However, the effective attachment of AgNPs onto such carbon-based surfaces has proven difficult to accomplish via inexpensive and rapid fabrication processes. In this study, we introduce a simple laser-assisted process that enables rapid surface functionalization and immobilization of AgNPs onto carbon cloth membrane surfaces comprised of woven carbon micro fibers. The laser functionalization provides a unique modification in surface morphology of …

Instability Of Glucocorticoid Metabolites In Coyote Scats: Implications For Field Sampling, Erika T. Stevenson, Eric M. Gese, Lorin A. Neuman-Lee, Susannah S. French

United States Department of Agriculture Wildlife Services: Staff Publications

Studying physiologic stress responses can assist in understanding the welfare of animals. One method of measuring the physiologic stress response is evaluating concentrations of glucocorticoid metabolites in feces. Previously, using an adrenocorticotropic hormone challenge, we found fecal glucocorticoid metabolite levels were a reliable indicator of physiologic stress response in coyotes (Canis latrans). We determine whether glucocorticoid metabolite concentrations remain stable when collecting feces over a 2-week period, a timeframe commonly used in scat surveys for wild canids. We collected feces from 6 captive coyotes maintained at the U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Predator …

Rabies Virus-Based Covid-19 Vaccine Coravax™ Induces High Levels Of Neutralizing Antibodies Against Sars-Cov-2., Drishya Kurup, Christoph Wirblich, Holly Ramage, Matthias J Schnell

Department of Microbiology and Immunology Faculty Papers

The recently emerged coronavirus SARS-CoV-2, the causative agent of COVID-19, is rapidly spreading in the world. The exponentially expanding threat of SARS-CoV-2 to global health highlights the urgent need for a vaccine. Herein we show the rapid development of a novel, highly efficient, and safe COVID-19 vaccine using a rabies virus-based vector that has proven to be an efficient vaccine against several emerging infectious diseases. This study reports that both a live and an inactivated rabies virus containing the SARS-CoV-2 spike S1 protein induces potent virus-neutralizing antibodies at much higher levels than seen in the sera of convalescent patients. In …

Chairs Of Excellence Annual Report 2020, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

Japanese Government Actions Against Covid-19 Under The Directives Of Constitutional And Administrative Law, Yuichiro Tsuji

Cardozo International & Comparative Law Review

This paper presents law on the State ofEmergency held jointly on June 16, 2020, by the Asian Law Center of Melbourne University and School of Law, and Vietnam National University, Hanoi.

This paper further elucidates the actions of the Japanese government against COVID-19 during the first five months of 2020. On May 25, 2020, the government fied the emergency declaration passed under the amended Art. 49(2) of the amended Influenza Special Measures Act (ISMA).

This paper argues that the effects of the Japanese government action is not unique, but is instead similar to those of other countries. In 2012, the …

Global Partnership To Make Available 120 Million Affordable, Quality Covid-19 Rapid Tests For Low- And Middle-Income Countries

Saudi Medical Journal

No abstract provided.

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2019, Kayla R Stover, Elias B Chahine, David Cluck, Sarah Green, Daniel B Chastain, Darrell Childress, Carmen Faulkner-Fennell, Katherine Lusardi, Edo-Abasi U. Mcgee, Michelle Turner, P Brandon Bookstaver, Christopher M Bland

PCOM Scholarly Works

Staying current on literature related to antimicrobial stewardship can be challenging given the ever-increasing number of published articles. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship-related peer-reviewed literature that detailed an actionable intervention for 2019. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training and to identify potential intervention opportunities within one's institution.

Covid-19 And The Case For Global Development, Johan A. Oldekop, Rory Horner, David Hulme, Roshan Adhikari, Bina Agarwal, Matthew Alford, Oliver Bakewell, Nicola Banks, Stephanie Barrientos, Tanja Bastia, Anthony J. Bebbington, Upasak Das, Ralitza Dimova, Richard Duncombe, Charis Enns, David Fielding, Christopher Foster, Timothy Foster, Tomas Frederiksen, Ping Gao, Tom Gillespie, Richard Heeks, Sam Hickey, Martin Hess, Nicholas Jepson, Ambarish Karamchedu, Uma Kothari, Aarti Krishnan, Tom Lavers, Aminu Mamman, Diana Mitlin, Negar Monazam Tabrizi

Geography

COVID-19 accentuates the case for a global, rather than an international, development paradigm. The novel disease is a prime example of a development challenge for all countries, through the failure of public health as a global public good. The COVID-19 pandemic has highlighted the falsity of any assumption that the global North has all the expertise and solutions to tackle global challenges, and has further highlighted the need for multi-directional learning and transformation in all countries towards a more sustainable and equitable world. We illustrate our argument for a global development paradigm by examining the implications of the COVID-19 pandemic …

Remarks, Jon Soderstrom

Fordham Law Review

No abstract provided.

Kansas Speaks Fall 2020 Statewide Public Opinion Survey, Brett Zollinger Ph.D., Jian Sun Ph.D., Michael Walker M.S., Luis Montelongo M.B.A.

Docking Institute of Public Affairs

The 2020 Kansas Speaks fall survey were conducted from September 21 to October 1. A panel of 417 adult residents of Kansas age 18 and older were surveyed online to assess their attitudes and opinions regarding various issues of interest to Kansas citizens.