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Identification Of Gut Microbiome Composition Responsible For Gas Production, Erasme Mutuyemungu Nov 2022

Identification Of Gut Microbiome Composition Responsible For Gas Production, Erasme Mutuyemungu

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Gas production remains a significant barrier to increasing intake of dietary fiber-containing foods for many consumers. Therefore, this thesis is comprised of two studies focusing on the role of the gut microbiome in contributing to gas production during fermentation of dietary components. Previous studies have reported significant correlations between Megasphaera elsdenii and gas production during fermentation of pulses. Therefore, the objective of the first study was to determine the role of M. elsdenii in gas production by the microbiome during fermentation of foods commonly associated with gas production. Human fecal microbiomes were separated based on the presence (Me+) or absence …


Integrated Xenosurveillance Of Loa Loa, Wuchereria Bancrofti, Mansonella Perstans And Plasmodium Falciparum Using Mosquito Carcasses And Faeces: A Pilot Study In Cameroon, Joseph Pryce, Nils Pilotte, Benjamin Menze, Allison R. Sirois, Michael Zulch, Jean Pierre Agbor, Steven A. Williams, Charles S. Wondji, Lisa Reimer Nov 2022

Integrated Xenosurveillance Of Loa Loa, Wuchereria Bancrofti, Mansonella Perstans And Plasmodium Falciparum Using Mosquito Carcasses And Faeces: A Pilot Study In Cameroon, Joseph Pryce, Nils Pilotte, Benjamin Menze, Allison R. Sirois, Michael Zulch, Jean Pierre Agbor, Steven A. Williams, Charles S. Wondji, Lisa Reimer

Biological Sciences: Faculty Publications

Background Community presence of loiasis must be determined before mass drug administration programmes for lymphatic filariasis and onchocerciasis can be implemented. However, taking human blood samples for loiasis surveillance is invasive and operationally challenging. A xenosurveillance approach based on the molecular screening of mosquitoes and their excreta/feces (E/F) for Loa loa DNA may provide a non-invasive method for detecting the community presence of loiasis. Methods We collected 770 wild mosquitoes during a pilot study in a known loiasis transmission area in Mbalmayo, Cameroon. Of these, 376 were preserved immediately while 394 were kept in pools to collect 36-hour E/F samples …


A Microbiological Assay Of Common Operating Room (Or) Tapes: Developing A Culture For Patient Safety, Gaurav Chauhan, Aman Upadhyay, Samvid Dwivedi, Robert J. Tibbetts, Suresh K. Srinivasan Nov 2022

A Microbiological Assay Of Common Operating Room (Or) Tapes: Developing A Culture For Patient Safety, Gaurav Chauhan, Aman Upadhyay, Samvid Dwivedi, Robert J. Tibbetts, Suresh K. Srinivasan

Pathology and Laboratory Medicine Articles

BACKGROUND: There are no existing practices or methods to ensure cleanliness, sterility, or prevent cross-contamination when it comes to common operating room (OR) tape. The authors hypothesized that adhesive tapes used by anesthesia providers in ORs and off-site surgical areas might be colonized by microorganisms and that culturing these tape rolls would reveal significant monomicrobial and polymicrobial contamination.

Material and Methods: The primary objective of this observational cohort study was to report and compare contamination rate including polymicrobial contamination rate between tape specimens collected from storage site and specimen from the ORs, off-sites, and after use on a patient. The …


Evaluate The Side Effect Associated With Covid-19 Vaccine On Adolescents In Riyadh, Saudi Arabia: A Cross-Section Study, Jehad A. Aldali, Fahad T. Alotaibi, Glowi A. Alasiri, Renad A. Almesned, Aroob M. Alromih, Afnan M. Almohandes, Shahad F. Alsenidi Nov 2022

Evaluate The Side Effect Associated With Covid-19 Vaccine On Adolescents In Riyadh, Saudi Arabia: A Cross-Section Study, Jehad A. Aldali, Fahad T. Alotaibi, Glowi A. Alasiri, Renad A. Almesned, Aroob M. Alromih, Afnan M. Almohandes, Shahad F. Alsenidi

Saudi Medical Journal

Objectives: To investigate the side effects of Pizer- BioNTech mRNA (BNT162b2) and Spikevax (mRNA- 1273) Coronavirus disease 2019 (COVID-19) vaccines on adolescents in Riyadh, Saudi Arabia. Methods: A cross-sectional study using an online questionnaire was carried out among COVID-19 vaccine adolescent recipients in Riyadh, Saudi Arabia. After receiving at least one dose of each vaccine, general and demographic data were collected, and vaccine-related side effects were evaluated. Results: The final sample consisted of 604 participants with a majority age group of 16-17 years old. Approximately 89.1% of the study participants were female. Most participants reported pain at the injection site …


Applying Technology To Promote Sexual And Reproductive Health And Prevent Gender Based Violence For Adolescents In Low And Middle-Income Countries: Digital Health Strategies Synthesis From An Umbrella Review, Keng-Yen Huang, Manasi Kumar, Sabrina Cheng, Anya Elena Urcuyo, Paul Macharia Nov 2022

Applying Technology To Promote Sexual And Reproductive Health And Prevent Gender Based Violence For Adolescents In Low And Middle-Income Countries: Digital Health Strategies Synthesis From An Umbrella Review, Keng-Yen Huang, Manasi Kumar, Sabrina Cheng, Anya Elena Urcuyo, Paul Macharia

Brain and Mind Institute

Aim: Adolescents in low-and-middle-income countries (LMICs) are facing numerous developmental, sexual and reproductive health (SRH) challenges including exposure to multidimensional violence. Gender-based violence (GBV) specifically intimate partner violence (IPV) are both highly prevalent in LMICs and are strongly linked with poor SRH outcomes. However, GBV and IPV interventions have not yet been adequately integrated in SRH due to individual, social, cultural, service, and resource barriers. To promote long-term SRH, a more holistic approach that integrates GBV and IPV, and adolescent development needs is imperative. Digital health has the potential to address multiple service setup, provision, and addressing access barriers through …


Toward A Pedagogical Criticism: The Text, The Teacher, And The Global Crisis In Teaching Health And Illness Literature, John Paolo Sarce Nov 2022

Toward A Pedagogical Criticism: The Text, The Teacher, And The Global Crisis In Teaching Health And Illness Literature, John Paolo Sarce

English Faculty Publications

The COVID-19 pandemic calls for a change of perspective in the educational landscape, and the literary classroom is revealed to be one of the classes that can quickly adopt this change. Teachers of literature began to curate on their syllabi texts that will signify the global feeling and experience of the pandemic. This transforms the literary classroom into a space that directly connects the experiences of students to this ongoing health crisis. The different literary texts read in classes are portals for students to understand the experience of illness as both historical and sociological phenomena. With these events in class, …


County-Level Societal Predictors Of Covid-19 Cases And Deaths Changed Through Time In The United States: A Longitudinal Ecological Study, Philip J. Bergmann, Nathan A. Ahlgren, Rosalie A. Torres Stone Nov 2022

County-Level Societal Predictors Of Covid-19 Cases And Deaths Changed Through Time In The United States: A Longitudinal Ecological Study, Philip J. Bergmann, Nathan A. Ahlgren, Rosalie A. Torres Stone

Biology

People of different racial/ethnic backgrounds, demographics, health, and socioeconomic characteristics have experienced disproportionate rates of infection and death due to COVID-19. This study tests if and how county-level rates of infection and death have changed in relation to societal county characteristics through time as the pandemic progressed. This longitudinal study sampled monthly county-level COVID-19 case and death data per 100,000 residents from April 2020 to March 2022, and studied the relationships of these variables with racial/ethnic, demographic, health, and socioeconomic characteristics for 3125 or 97.0% of U.S. counties, accounting for 96.4% of the U.S. population. The association of all county-level …


Paid Sick Leave's Payoff, Jennifer B. Shinall Nov 2022

Paid Sick Leave's Payoff, Jennifer B. Shinall

Vanderbilt Law Review

Perhaps paid sick days have never been more valuable than during the COVID-19 pandemic. Yet even before COVID-19, seventeen states and the District of Columbia began passing legislative mandates that employers provide employees with paid sick leave (“PSL”) days. Most of this legislation requires employers to provide up to one week of PSL for both full- and part-time employees, which they can utilize with few notice or documentation requirements. Using the 2017–2018 American Time Use Survey Leave and Job Flexibilities Module, I first demonstrate that workers in PSL states are less likely to go to work sick, which may, in …


A Comparison Of Mini-Flotac And Mcmaster Techniques, Overdispersion And Prevalence Of Parasites In Naturally Infected North American Bison (Bison Bison) In The Usa, Wiliam L. Johnson, Samantha Reynolds, Colton L. Adkins, Bradly Wehus-Tow, Jameson R. Brennan, Catherine B. Krus, Danielle Buttke, Jeff M. Martin, Jeba R.J. Jesudoss Chelladurai Nov 2022

A Comparison Of Mini-Flotac And Mcmaster Techniques, Overdispersion And Prevalence Of Parasites In Naturally Infected North American Bison (Bison Bison) In The Usa, Wiliam L. Johnson, Samantha Reynolds, Colton L. Adkins, Bradly Wehus-Tow, Jameson R. Brennan, Catherine B. Krus, Danielle Buttke, Jeff M. Martin, Jeba R.J. Jesudoss Chelladurai

Natural Resource Management Faculty Publications

Several quantitative diagnostic techniques are available to estimate gastrointestinal parasite counts in the feces of ruminants. Comparing egg and oocyst magnitudes in naturally infected samples has been a recommended approach to rank fecal techniques. In this study, we compared the Mini-FLOTAC (sensitivity of 5 eggs per gram (EPG)/oocysts per gram (OPG)) and different averaged replicates of the modified McMaster techniques (sensitivity of 33.33 EPG/OPG) in 387 fecal samples from 10 herds of naturally infected North American bison in the Central Great Plains region of the USA. Both techniques were performed with fecal slurries homogenized in a fill-FLOTAC device. In the …


Blood Lead Levels Among Afghan Children In The United States, 2014-2016, Clelia Pezzi, Gayathri S. Kumar, Deborah Lee, Nuny Cabanting, Breanna Kawasaki, Lori Kennedy, Jenny Aguirre, Melissa Titus, Rebecca Ford, Blain Mamo, Kailey Urban, Stephen Hughes, Colleen Payton, Marc Altshuler, Jessica Montour, Emily S. Jentes Nov 2022

Blood Lead Levels Among Afghan Children In The United States, 2014-2016, Clelia Pezzi, Gayathri S. Kumar, Deborah Lee, Nuny Cabanting, Breanna Kawasaki, Lori Kennedy, Jenny Aguirre, Melissa Titus, Rebecca Ford, Blain Mamo, Kailey Urban, Stephen Hughes, Colleen Payton, Marc Altshuler, Jessica Montour, Emily S. Jentes

Department of Family & Community Medicine Faculty Papers

Lead poisoning disproportionately affects children and can result in permanent neurologic damage.1 Although blood lead levels (BLLs) declined among children in the United States over the past several decades, children resettling to the United States from other countries emerged as a population at risk for BLLs that are higher than the United States blood lead reference value of $5 mg/dL at the time of this analysis.2 Among children screened for lead shortly after resettlement, children from Afghanistan have a higher prevalence of BLLs $5 mg/dL compared with children from other countries,3,4 but timely sources of data available for analysis are …


Comparison Of Evaluations For Heart Transplant Before Durable Left Ventricular Assist Device And Subsequent Receipt Of Transplant At Transplant Vs Nontransplant Centers, Thomas M. Cascino, Jeffrey S. Mccullough, Xiaoting Wu, Michael J. Pienta, James W. Stewart, Robert B. Hawkins, Alexander A. Brescia, Ashraf Abou El Ala, Min Zhang, Pierre-Emmanuel Noly, Jonathan W. Haft, Jennifer A. Cowger, Monica Colvin, Keith D. Aaronson, Francis D. Pagani, Donald S. Likosky Nov 2022

Comparison Of Evaluations For Heart Transplant Before Durable Left Ventricular Assist Device And Subsequent Receipt Of Transplant At Transplant Vs Nontransplant Centers, Thomas M. Cascino, Jeffrey S. Mccullough, Xiaoting Wu, Michael J. Pienta, James W. Stewart, Robert B. Hawkins, Alexander A. Brescia, Ashraf Abou El Ala, Min Zhang, Pierre-Emmanuel Noly, Jonathan W. Haft, Jennifer A. Cowger, Monica Colvin, Keith D. Aaronson, Francis D. Pagani, Donald S. Likosky

Cardiology Articles

IMPORTANCE: In 2020, the Centers for Medicare & Medicaid Services revised its national coverage determination, removing the requirement to obtain review from a Medicare-approved heart transplant center to implant a durable left ventricular assist device (LVAD) for bridge-to-transplant (BTT) intent at an LVAD-only center. The association between center-level transplant availability and access to heart transplant, the gold-standard therapy for advanced heart failure (HF), is unknown.

OBJECTIVE: To investigate the association of center transplant availability with LVAD implant strategies and subsequent heart transplant following LVAD implant before the Centers for Medicare & Medicaid Services policy change.

DESIGN, SETTING, AND PARTICIPANTS: A …


Evaluation Of Clinical And Laboratory Characteristics And Factors Affecting Mortality In 500 Hospitalized Covid-19 Patients: A Retrospective Study, Petek Ş. Konya, Neşe Demirtürk, Derya Korkmaz, Havva Tünay, Elif Betül Koşar Nov 2022

Evaluation Of Clinical And Laboratory Characteristics And Factors Affecting Mortality In 500 Hospitalized Covid-19 Patients: A Retrospective Study, Petek Ş. Konya, Neşe Demirtürk, Derya Korkmaz, Havva Tünay, Elif Betül Koşar

Saudi Medical Journal

Objectives: To evaluate the clinical and laboratory characteristics of COVID-19 patients admitted to Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey, and to determine the factors affecting mortality. Methods: A total of 500 patients who were diagnosed with COVID-19 between 19th of March and 30th of September 2020 in Afyonkarahisar Health Sciences University, Faculty of Medicine, Pandemic Service, Afyonkarahisar, Turkey, were retrospectively investigated for this study. These individuals’ prognoses, demographic, clinical, laboratory, and radiological information were examined and recorded retrospectively. Comparisons were carried out between the characteristics of patients with a prognosis of death and those who recovered. Results: Of the 500 …


Why Do The Police Reject Counseling? An Examination Of Necessary Changes To Police Subculture. Necessary Changes To Police Subculture., Noel Otu, Ntiense E. Otu Nov 2022

Why Do The Police Reject Counseling? An Examination Of Necessary Changes To Police Subculture. Necessary Changes To Police Subculture., Noel Otu, Ntiense E. Otu

Criminal Justice Faculty Publications

This paper reviews the concept of police subculture and examines its role in the management and acceptance of treatment for stress-related injury. In particular, we examine the impact of stigma that attaches to treatment within this subculture. The persistence of the dominant police subculture remains a significant obstacle to officers seeking treatment for stress-related illnesses. The subculture has historically resisted acknowledging the need for treatment in response to the occupational and/or organizational stress-related injury that results from frequent exposure to work-related trauma. Many police administrators are still embedded within and resist changes to the subculture, which results in an atmosphere …


Cancer Research Across Africa: A Comparative Bibliometric Analysis, Miriam Mutebi, Grant Lewison, Ajay Aggarwal, Olusegun Isaac Alatise, Christopher Booth, Miska Cira, Surbhi Grover, Ophira Ginsburg, Julie Gralow, Serine Gueye Nov 2022

Cancer Research Across Africa: A Comparative Bibliometric Analysis, Miriam Mutebi, Grant Lewison, Ajay Aggarwal, Olusegun Isaac Alatise, Christopher Booth, Miska Cira, Surbhi Grover, Ophira Ginsburg, Julie Gralow, Serine Gueye

General Surgery, East Africa

Introduction Research is a critical pillar in national cancer control planning. However, there is a dearth of evidence for countries to implement affordable strategies. The WHO and various Commissions have recommended developing stakeholder-based needs assessments based on objective data to generate evidence to inform national and regional prioritisation of cancer research needs and goals.

Methodology Bibliometric algorithms (macros) were developed and validated to assess cancer research outputs of all 54 African countries over a 12-year period (2009–2020). Subanalysis included collaboration patterns, site and domain-specific focus of research and understanding authorship dynamics by both position and sex. Detailed subanalysis was performed …


Individual Costs And Community Benefits: Collectivism And Individuals’ Compliance With Public Health Interventions, Suyi Leong, Kimin Eom, Keiko Ishii, Marion C. Aichberger, Karolina Fetz, Tim S. Müller, Heejung S. Kim, David K. Sherman Nov 2022

Individual Costs And Community Benefits: Collectivism And Individuals’ Compliance With Public Health Interventions, Suyi Leong, Kimin Eom, Keiko Ishii, Marion C. Aichberger, Karolina Fetz, Tim S. Müller, Heejung S. Kim, David K. Sherman

Research Collection School of Social Sciences

Differences in national responses to COVID-19 have been associated with the cultural value of collectivism. The present research builds on these findings by examining the relationship between collectivism at the individual level and adherence to public health recommendations to combat COVID-19 during the pre-vaccination stage of the pandemic, and examines different characteristics of collectivism (i.e., concern for community, trust in institutions, perceived social norms) as potential psychological mechanisms that could explain greater compliance. A study with a cross-section of American participants (N = 530) examined the relationship between collectivism and opting-in to digital contact tracing (DCT) and wearing face coverings …


Old Question With New Omicron Subvariant: Shall We Put The Masks Back On?, Shaodi Ma, Yuyan Wu, Yuemeng Jiang, Scott Lowe, Rachel Bentley, Mubashir Ayaz Ahmed, Chenyu Sun Nov 2022

Old Question With New Omicron Subvariant: Shall We Put The Masks Back On?, Shaodi Ma, Yuyan Wu, Yuemeng Jiang, Scott Lowe, Rachel Bentley, Mubashir Ayaz Ahmed, Chenyu Sun

Student Publications

No abstract provided.


A Case Report Of Concurrent Cryptococcal And Tuberculous Meningitis In An Immunosuppressed Renal Transplant Patient, Linda Barasa, Ahmed Sokwala, Felix Riunga, Dilraj Sokhi Nov 2022

A Case Report Of Concurrent Cryptococcal And Tuberculous Meningitis In An Immunosuppressed Renal Transplant Patient, Linda Barasa, Ahmed Sokwala, Felix Riunga, Dilraj Sokhi

Internal Medicine, East Africa

Infections after renal transplant are a common cause of morbidity and are commonly due to Cytomegalovirus (CMV), Cryptococcus, Mycobacterium tuberculosis, and Aspergillus. Concurrent infections with both cryptococcal and tuberculous aetiologies are rare within the central nervous system (CNS). We present a case of a 67-year-old male patient who presented with three weeks of headaches, confusion, unsteady gait, and seizures. He had type 2 diabetes mellitus and hypertension. He had a kidney transplant three years prior and was on three immunosuppressive agents. He was HIV-negative. He was evaluated and found to have cryptococcal meningitis and received appropriate treatment with liposomal amphotericin …


The Association Between Egocentric Sexual Networks And Sexual Meeting Venues With Prep Conversation And Encouragement For Use Among Latinx Men Who Have Sex With Men, Mariano Kanamori, Cho-Hee Shrader, Juan Flores-Arroyo, Ariana Johnson, Edda Rodriguez, Stephen Fallon, John Skvoretz, Victor Gonzalez, Susanne Doblecki-Lewis, Adam Carrico, Kayo Fujimoto, Mark Williams, Steven Safren Nov 2022

The Association Between Egocentric Sexual Networks And Sexual Meeting Venues With Prep Conversation And Encouragement For Use Among Latinx Men Who Have Sex With Men, Mariano Kanamori, Cho-Hee Shrader, Juan Flores-Arroyo, Ariana Johnson, Edda Rodriguez, Stephen Fallon, John Skvoretz, Victor Gonzalez, Susanne Doblecki-Lewis, Adam Carrico, Kayo Fujimoto, Mark Williams, Steven Safren

Faculty, Staff and Student Publications

Despite the increasing availability of pre-exposure prophylaxis (PrEP), Latinx men who have sex with men (LMSM) are not receiving PrEP-related information. To understand the influence of LMSM sexual networks on PrEP-related conversations and encouragement to use PrEP, this cross-sectional egocentric network study characterized the PrEP-related communication of 130 LMSM egos with 507 sexual partners (alters). Participants were recruited using respondent-driven sampling methods from a Miami-Dade County community-health organization. Egocentric-level data were collected from 2018-2019 and analyzed using multilevel modeling. Of egos, 30% reported using PrEP. Closeness between participants and sexual partners played a role in PrEP conversation and encouragement. Participants …


Disease Progression Of Whim Syndrome In An International Cohort Of 66 Pediatric And Adult Patients, Christoph B Geier, Maryssa Ellison, Rachel Cruz, Sumit Pawar, Alexander Leiss-Piller, Katarina Zmajkovicova, Shannon M Mcnulty, Melis Yilmaz, Martin Oman Evans, Sumai Gordon, Boglarka Ujhazi, Ivana Wiest, Hassan Abolhassani, Asghar Aghamohammadi, Sara Barmettler, Saleh Bhar, Anastasia Bondarenko, Audrey Anna Bolyard, David Buchbinder, Michaela Cada, Mirta Cavieres, James A Connelly, David C Dale, Ekaterina Deordieva, Morna J Dorsey, Simon B Drysdale, Stephan Ehl, Reem Elfeky, Francesca Fioredda, Frank Firkin, Elizabeth Förster-Waldl, Bob Geng, Vera Goda, Luis Gonzalez-Granado, Eyal Grunebaum, Elzbieta Grzesk, Sarah E Henrickson, Anna Hilfanova, Mitsuteru Hiwatari, Chihaya Imai, Winnie Ip, Soma Jyonouchi, Hirokazu Kanegane, Yuta Kawahara, Amer M Khojah, Vy Hong-Diep Kim, Marina Kojić, Sylwia Kołtan, Gergely Krivan, Daman Langguth, Yu-Lung Lau, Daniel Leung, Maurizio Miano, Irina Mersyanova, Talal Mousallem, Mica Muskat, Flavio A Naoum, Suzie A Noronha, Monia Ouederni, Shuichi Ozono, G Wendell Richmond, Inga Sakovich, Ulrich Salzer, Catharina Schuetz, Filiz Odabasi Seeborg, Svetlana O Sharapova, Katja Sockel, Alla Volokha, Malte Von Bonin, Klaus Warnatz, Oliver Wegehaupt, Geoffrey A Weinberg, Ke-Juin Wong, Austen Worth, Huang Yu, Yulia Zharankova, Xiaodong Zhao, Lisa Devlin, Adriana Badarau, Krisztian Csomos, Marton Keszei, Joao Pereira, Arthur G Taveras, Sarah L Beaussant-Cohen, Mei-Sing Ong, Anna Shcherbina, Jolan E Walter Nov 2022

Disease Progression Of Whim Syndrome In An International Cohort Of 66 Pediatric And Adult Patients, Christoph B Geier, Maryssa Ellison, Rachel Cruz, Sumit Pawar, Alexander Leiss-Piller, Katarina Zmajkovicova, Shannon M Mcnulty, Melis Yilmaz, Martin Oman Evans, Sumai Gordon, Boglarka Ujhazi, Ivana Wiest, Hassan Abolhassani, Asghar Aghamohammadi, Sara Barmettler, Saleh Bhar, Anastasia Bondarenko, Audrey Anna Bolyard, David Buchbinder, Michaela Cada, Mirta Cavieres, James A Connelly, David C Dale, Ekaterina Deordieva, Morna J Dorsey, Simon B Drysdale, Stephan Ehl, Reem Elfeky, Francesca Fioredda, Frank Firkin, Elizabeth Förster-Waldl, Bob Geng, Vera Goda, Luis Gonzalez-Granado, Eyal Grunebaum, Elzbieta Grzesk, Sarah E Henrickson, Anna Hilfanova, Mitsuteru Hiwatari, Chihaya Imai, Winnie Ip, Soma Jyonouchi, Hirokazu Kanegane, Yuta Kawahara, Amer M Khojah, Vy Hong-Diep Kim, Marina Kojić, Sylwia Kołtan, Gergely Krivan, Daman Langguth, Yu-Lung Lau, Daniel Leung, Maurizio Miano, Irina Mersyanova, Talal Mousallem, Mica Muskat, Flavio A Naoum, Suzie A Noronha, Monia Ouederni, Shuichi Ozono, G Wendell Richmond, Inga Sakovich, Ulrich Salzer, Catharina Schuetz, Filiz Odabasi Seeborg, Svetlana O Sharapova, Katja Sockel, Alla Volokha, Malte Von Bonin, Klaus Warnatz, Oliver Wegehaupt, Geoffrey A Weinberg, Ke-Juin Wong, Austen Worth, Huang Yu, Yulia Zharankova, Xiaodong Zhao, Lisa Devlin, Adriana Badarau, Krisztian Csomos, Marton Keszei, Joao Pereira, Arthur G Taveras, Sarah L Beaussant-Cohen, Mei-Sing Ong, Anna Shcherbina, Jolan E Walter

Faculty, Staff and Students Publications

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 (CXCR4) gene. We characterize a unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct CXCR4 genetic variants within our cohort, 11 were novel pathogenic variants affecting 15 individuals (23%). All variants affect the same CXCR4 region and impair CXCR4 internalization resulting in hyperactive signaling. The median age of diagnosis in our cohort (5.5 years) indicates WHIM syndrome can commonly present in childhood, although some patients are not …


Monkeypox Prevention And Protecting Sex Workers: A Call To Action, Randi Beth Singer, Amy K. Johnson, Jessica L. Zemlak, Ariel Shensa, Rebecca M. Singer, Cocoa Costales, Kathleen Chiu, Jahari Stamps Nov 2022

Monkeypox Prevention And Protecting Sex Workers: A Call To Action, Randi Beth Singer, Amy K. Johnson, Jessica L. Zemlak, Ariel Shensa, Rebecca M. Singer, Cocoa Costales, Kathleen Chiu, Jahari Stamps

College of Nursing Faculty Research and Publications

No abstract provided.


Re-Examining The Widespread Policy Of Stopping Sodium-Glucose Cotransporter-2 Inhibitors During Acute Illness: A Perspective Based On The Updated Evidence, Kamlesh Khunti, Vanita R Aroda, Deepak L Bhatt, Biykem Bozkurt, John B Buse, Hiddo L Heerspink, Silvio E Inzucchi, Carolyn S P Lam, Nikolaus Marx, John J V Mcmurray, Scott D Solomon, Mikhail N Kosiborod Nov 2022

Re-Examining The Widespread Policy Of Stopping Sodium-Glucose Cotransporter-2 Inhibitors During Acute Illness: A Perspective Based On The Updated Evidence, Kamlesh Khunti, Vanita R Aroda, Deepak L Bhatt, Biykem Bozkurt, John B Buse, Hiddo L Heerspink, Silvio E Inzucchi, Carolyn S P Lam, Nikolaus Marx, John J V Mcmurray, Scott D Solomon, Mikhail N Kosiborod

Faculty, Staff and Students Publications

Sodium-glucose cotransporter-2 (SGLT2) inhibitors are now seen as an integral part of therapy in type 2 diabetes to control not only blood glucose but to improve cardiovascular and kidney outcomes. Diabetic ketoacidosis (DKA) is an uncommon but serious complication of type 2 diabetes, which has a high case fatality rate. The absolute risk of DKA in large, prospective randomized clinical trials in people with type 2 diabetes using SGLT2 inhibitors has been low, although the relative risk is higher in those assigned to SGLT2 inhibitors compared with placebo. In those without diabetes but prescribed SGLT2 inhibitors for heart failure or …


Immune Dysfunction Signatures Predict Outcomes And Define Checkpoint Blockade-Unresponsive Microenvironments In Acute Myeloid Leukemia, Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung-On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Kramer, Hanna A Knaus, Bruce R Blazar, Vedran Radojcic, Joshua F Zeidner, Andrea Arruda, Bofei Wang, Hussein A Abbas, Mark D Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik Nov 2022

Immune Dysfunction Signatures Predict Outcomes And Define Checkpoint Blockade-Unresponsive Microenvironments In Acute Myeloid Leukemia, Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung-On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Kramer, Hanna A Knaus, Bruce R Blazar, Vedran Radojcic, Joshua F Zeidner, Andrea Arruda, Bofei Wang, Hussein A Abbas, Mark D Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik

Faculty, Staff and Student Publications

Background

Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generation of senescent-like CD8+ T cells and whether they have prognostic relevance.

METHODS

We analyzed NanoString, bulk RNA-Seq and single-cell RNA-Seq data from independent clinical cohorts comprising 1,896 patients treated with chemotherapy and/or immune checkpoint blockade (ICB).

Results

We show that senescent-like bone marrow CD8+ T cells were impaired in killing autologous AML blasts and that their proportion negatively correlated with overall survival …


Risk Factors For Community-Acquired Bacterial Infection Among Young Infants In South Asia: A Longitudinal Cohort Study With Nested Case-Control Analysis, Nicholas E Connor, Mohammad Shahidul Islam, Luke C Mullany, Nong Shang, Zulfiqar A Bhutta, Anita K M Zaidi, Sajid Soofi, Imran Nisar, Pinaki Panigrahi, Kalpana Panigrahi, Radhanath Satpathy, Anuradha Bose, Rita Isaac, Abdullah H Baqui, Dipak K Mitra, Qazi Sadeq-Ur Rahman, Tanvir Hossain, Stephanie J Schrag, Jonas M Winchell, Melissa L Arvay, Maureen H Diaz, Jessica L Waller, Martin W Weber, Davidson H Hamer, Patricia Hibberd, A S M Nawshad Uddin Ahmed, Maksuda Islam, Mohammad Belal Hossain, Shamim A Qazi, Shams El Arifeen, Gary L Darmstadt, Samir K Saha Nov 2022

Risk Factors For Community-Acquired Bacterial Infection Among Young Infants In South Asia: A Longitudinal Cohort Study With Nested Case-Control Analysis, Nicholas E Connor, Mohammad Shahidul Islam, Luke C Mullany, Nong Shang, Zulfiqar A Bhutta, Anita K M Zaidi, Sajid Soofi, Imran Nisar, Pinaki Panigrahi, Kalpana Panigrahi, Radhanath Satpathy, Anuradha Bose, Rita Isaac, Abdullah H Baqui, Dipak K Mitra, Qazi Sadeq-Ur Rahman, Tanvir Hossain, Stephanie J Schrag, Jonas M Winchell, Melissa L Arvay, Maureen H Diaz, Jessica L Waller, Martin W Weber, Davidson H Hamer, Patricia Hibberd, A S M Nawshad Uddin Ahmed, Maksuda Islam, Mohammad Belal Hossain, Shamim A Qazi, Shams El Arifeen, Gary L Darmstadt, Samir K Saha

Faculty, Staff and Student Publications

OBJECTIVE: Risk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship.

METHODS: Five sites in Bangladesh, India and Pakistan enrolled mother-child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic and epidemiological risk factor data were collected. Young infants aged 0-59 days with signs of possible serious bacterial infection (pSBI) and age-matched controls provided blood and respiratory specimens that were analysed by blood culture and real-time PCR. These tests were used to build …


Rsif Tanzania Country Report 2022, Rsif In Tanzania 2022 Nov 2022

Rsif Tanzania Country Report 2022, Rsif In Tanzania 2022

Rsif Country Progress Reports

Tanzania is part of PASET and has expressed its intention to contribute to Rsif. There are 11 competitively selected Tanzanian Rsif PhD students (73% women) in four thematic areas in four different African Host Universities. Two Tanzanian universities were competitively selected as Rsif African host universities: Sokoine University of Agriculture in Food security and agribusiness in 2017 and Nelson Mandela African Institution of Science and Technology, (NM-AIST) in mineral, mining and material science in 2019. They are hosting a total of 60 Rsif PhD students from 20 different nationalities with 50 publications in high impact journals to date. There are …


Caring For Patients Using Methamphetamines: An Interprofessional Collaborative Approach, Erinne Kennedy, Sarah E. Getch, Benjamin Grin, Russell D. Campillo, Linda C. Niessen Nov 2022

Caring For Patients Using Methamphetamines: An Interprofessional Collaborative Approach, Erinne Kennedy, Sarah E. Getch, Benjamin Grin, Russell D. Campillo, Linda C. Niessen

Faculty and Staff Publications

Methamphetamine use is increasing in the U.S. and in Missouri, as are the number of deaths associated with its use. Many systemic and mental health issues are associated with methamphetamine use or methamphetamine use disorder (MUD). Given the range of health issues associated with methamphetamine use or MUD, a collaborative approach to the care of patients can improve outcomes. This article provides an overview of a collaborative approach to caring for patients using or have used methamphetamine, from the perspective of the primary care, behavioral and dental clinician.


Evaluation Of The Effectiveness Of Uv-C Dose For Photoinactivation Of Sars-Cov-2 In Contaminated N95 Respirator, Surgical And Cotton Fabric Masks, Patrícia Metolina, Lilian Gomes De Oliveira, Bruno Ramos, Yan De Souza Angelo, Paola Minoprio, Antonio Carlos Silva Costa Teixeira Nov 2022

Evaluation Of The Effectiveness Of Uv-C Dose For Photoinactivation Of Sars-Cov-2 In Contaminated N95 Respirator, Surgical And Cotton Fabric Masks, Patrícia Metolina, Lilian Gomes De Oliveira, Bruno Ramos, Yan De Souza Angelo, Paola Minoprio, Antonio Carlos Silva Costa Teixeira

Faculty, Staff and Student Publications

As part of efforts to combat the Covid-19 pandemic and decrease the high transmissibility of the new coronavirus, SARS-CoV-2, effective inactivation strategies, such as UV-C decontamination technologies, can be reliably disseminated and well-studied. The present study investigated the susceptibility of a high viral load of SARS-CoV-2 in filtering facepiece respirators (FFR) N95, surgical mask, cotton fabric mask and N95 straps under three different doses of UV-C, applying both real-time PCR (qPCR) and plaque formation assays to quantify viral load reduction and virus infectivity, respectively. The results show that more than 95% of the amount of SARS-CoV-2 RNA could be reduced …


Infertility Characterization, Factors Associated With Primary Infertility, And Seroprevalence Of Genital Infections: A Cross-Sectional Survey In Abu Dhabi, United Arab Emirates, Noor Motea Abdo Nov 2022

Infertility Characterization, Factors Associated With Primary Infertility, And Seroprevalence Of Genital Infections: A Cross-Sectional Survey In Abu Dhabi, United Arab Emirates, Noor Motea Abdo

Dissertations

Worldwide, infertility affects 8%–10% of couples and it could be primary or secondary. In the United Arab Emirates (UAE), one in every six couples are facing difficulties in conceiving. However, there is a noticeable lack of epidemiological studies and empirical data characterizing populations seeking infertility treatment in the UAE. Therefore, to inform health policy planning, evidence-based data is required to understand the most common type of infertility and the burden of exposure to genital pathogens. To characterize fertility-treatment-seeking patients, investigate factors associated with primary infertility, and to estimate the seroprevalence of six pathogens known to be transmitted genitally and associated …


Lactic Acid Bacteria Isolated From Fresh Vegetable Products: Potential Probiotic And Postbiotic Characteristics Including Immunomodulatory Effects, Fatima Khaled Alameri Nov 2022

Lactic Acid Bacteria Isolated From Fresh Vegetable Products: Potential Probiotic And Postbiotic Characteristics Including Immunomodulatory Effects, Fatima Khaled Alameri

Theses

The ability to perform effectively in the gastrointestinal system (GIT) is one of the most significant criteria for selecting the best probiotic bacteria. Thus, the present study aimed to investigate the potential probiotic characteristics of some selected lactic acid bacteria (LAB) isolated from vegetable products. Probiotic characteristics included tolerance to acid and bile, cholesterol removing ability, bile salt hydrolysis, resistance against lysozyme and antibiotics, production of exopolysaccharides (EPS), antimicrobial and hemolytic activities, and cell surface characteristics (auto-aggregation, co-aggregation, and hydrophobicity). Out of 46 isolates, 17 isolates that exhibited remarkable survivability under gastrointestinal conditions were selected for further analysis. Almost all …


التأمین من المسؤولیة المدنیة الناجمة عن انتقال الأمراض المعدية (فایروس كورونا كمثال), موزة عبدالله النعیمي Nov 2022

التأمین من المسؤولیة المدنیة الناجمة عن انتقال الأمراض المعدية (فایروس كورونا كمثال), موزة عبدالله النعیمي

Theses

No abstract provided.


A Data Driven Model To Promote Preparedness And Respond Intelligently To Pandemic Outbreaks, Safea Mohammed Al Senani Nov 2022

A Data Driven Model To Promote Preparedness And Respond Intelligently To Pandemic Outbreaks, Safea Mohammed Al Senani

Theses

The COVID-19 pandemic has had a major effect on various vital sectors of the economy, including education healthcare, and the industry. Governments have imposed strict regulations to reduce the spread of this global disease outbreak. Consequently, working from home, online learning, social distancing and various control measures were enforced. In response, many schools shifted to distance learning, although most of these schools were neither technically ready nor administratively prepared for the online transition. Despite recent progress, countries are still experiencing daunting challenges to control the infection rate and magnitude, stabilize the economy, and relax socialization and public life activities. Decision-makers …