Digital Commons Network^™

Surgical Intervention For Endobronchial Tuberculosis With Total Bronchial Occlusion: A Case Report, Muhammad A. Putra, Matthew Billy, Radhyaksa Ardaya, Rut Hp Ekasiwi, Sari Rahmawati, Karel Hs Sumarsudi

The New Ropanasuri Journal of Surgery

Introduction. Endobronchial Tuberculosis (EBTB) is a specific TB form affecting the tracheobronchial tree with microbial and histopathological evidence. Early diagnosis is essential to provide timely treatment and prevent complications but also proves difficult due to the low positive rate of acid–fast bacilli (AFB) staining of sputum smears and non–specific clinical and radiological findings.

Case Illustration. We reported a 19–year–old man with a productive cough suspected of pulmonary tuberculosis, with a positive GeneXpert test and negative AFB smear. He received anti–tuberculosis drugs for six months. Although the symptoms initially seemed to improve, the patient complained of dyspnea during moderate activities in …

Editor's Note, Anucha Apisarnthanarak

Asian Medical Journal and Alternative Medicine

No abstract provided.

Probiotic Supplementations Preserve Protective Immunity Against Sars-Cov-2 Spike Protein After A Triple Combination Of Covid-19 Vaccination, Aphitchaya Chanbunyavit, Vitoon Jularattanaporn, Thamthiwat Nararatwanchai

Asian Medical Journal and Alternative Medicine

Introduction: Immunoglobulin G against SARS-CoV-2 spike protein declines over-time in vaccinated individuals. Trend to restore protective immunity is challenging.

Objectives: Probiotics have beneficial effects to human innate and adaptive immune responses. This study aimed to compare immune preservation of probiotic supplement versus placebo by measuring the mean and percent reduction of COVID-19 antibody level among those subjects receiving a triple dose combination of COVID-19 vaccine.

Methods: A randomized, double-blinded, placebo-controlled trial, conducted in Bangkok-Samui hospital between December 2021 to February 2022. There were 30 volunteers, divided randomly into 2 groups. The target group received probiotics supplement once daily for 6 …

The Impact On Gay Men Of Support And Enforcement Of Workplace Dei Policies: A Meta Analysis, Steven M. Vega

Student Theses and Dissertations

The poor enforcement of workplace DEI policies affects gay men in ways that are unique and invite close attention. The nature of the impact of missing or unsupported DEI policies on gay men has been widely debated in the field of human resources and communication studies, with scholars such as David Wicks, Helen Seitzer, James Ward, and Diana Winstansley arguing that these effects include lasting negative mental and physical health effects and discomfort with self-disclosure in the workplace. However, the existing research on this topic has not sufficiently considered the effects of the poor enforcement of workplace DEI policies side …

Predation Of Vertebrates By Domestic Cats In Two Brazilian Hotspots: Incidental Records And Literature Review, Clodoaldo Lopes Assis, Camila Moura Novaes, Marcelo Augusto Pereira Coelho Dias, Jhonny José Magalhães Guedes, Renato Neves Feio, Guilherme Siniciato Terra Garbino

Neotropical Biodiversity

No abstract provided.

Anthelmintic Resistance In Sheep Across Ireland And The Uk: A Literature Review Of The In Vivo Versus In Vitro Methods, Megan Tumulty

SURE Journal: Science Undergraduate Research Experience Journal

Background: The animal welfare and production consequences of gastrointestinal nematode infections, namely Nematodirus battus, on sheep are compelling. The control of gastrointestinal infections has been heavily reliant on the administration of anthelmintics since their introduction into mainstream use in 1960. However, their frequent and often excessive use has resulted in anthelmintic resistance being reported extensively in several gastrointestinal nematode species. The prevalence of anthelmintic resistance as well as the increase in the number of cases of multiple-drug resistance in nematode populations now poses substantial hindrance on the viability of sheep production systems. However, despite the threat N. battus poses …

Interosseous Access Osteomyelitis, Omar Siddiqui, Adnaan Sheikh, Rohail Baig, Harsha Surath, Siri Chadalavada, Firas Siddiqui, Ganesh Arun, Jaskarn Virk, Nikita Shah

Advances in Clinical Medical Research and Healthcare Delivery

Intraosseous (IO) access is a recommended technique in cases of an emergency situation where IV access cannot be obtained. Despite advancements in IO devices and FDA approval of many types of IO devices, it has various complications that although are rare, can be potentially life-threatening. We report a case of acute tibial osteomyelitis in an adult female with a history of polysubstance drug abuse a few weeks after an IO access from a previous hospital stay.

Case Study: Abnormal Presentation Of Infective Endocarditis With Streptococcus Canis And Chiari Network, Shahbaz Afzal, Ryan Russell, Alexander Chekhov

Advances in Clinical Medical Research and Healthcare Delivery

Here we present a rare case of infective endocarditis (IE) with Streptococcus canis and Chiari network in an 85 year old female living with multiple dogs and open skin of lower extremity predisposing her to bacteremia. Underlying abnormalities of the cardiac chambers such as Chiari network predisposes to a higher incidence of bacterial seeding and causing IE. A Chiari network is usually asymptomatic and of no clinical significance but can worsen prognosis in IE. IE carries a significant morbidity and mortality burden and when diagnosed early can be a lifesaving diagnosis. Due to the wide range of complications, early diagnosis …

Mystery Rash: Atypical Presentation Of Suspected Cat-Scratch Disease In Primary Care, Nicole Hunter, Rutwik Pradeep Sharma, Omobolanle Adetimehin, Yasir Loai

Advances in Clinical Medical Research and Healthcare Delivery

No abstract provided.

Evaluation Of Antibody Response To Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Vaccination In Patients With Lymphoid And Solid Organ Malignancies, Mukul Singal, Sanjana Kalvehalli Kashinath, S. Shahzad Mustafa, Edward Walsh, Karthik Vadamalai, Saad Jamshed

Advances in Clinical Medical Research and Healthcare Delivery

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. There is emerging evidence regarding suboptimal response to vaccination against COVID-19 in patients with hematologic and solid organ malignancies.

We conducted a single-center prospective study assessing seroconversion in response to vaccination against COVID-19 in 53 patients with chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), and solid organ malignancies.

A quantitative immunoassay of IgG antibodies to SARS-CoV-2 Spike (S) protein was measured prior to vaccination and at 2 weeks after completion of two-dose vaccination series. A fourfold increase in antibody titers was considered positive …

Knowing The Biosphere: Documentation, Specimens, Archives, And Names Reveal Environmental Change And Emerging Pathogens, Eric P. Hoberg, Valeria Trivellone, Joseph A. Cook, Jonathan L. Dunnum, Walter A. Boeger, Daniel R. Brooks, Salvatore J. Agosta, Jocelyn P. Colella

MANTER: Journal of Parasite Biodiversity

One Health programs and trajectories are now the apparent standard for exploring the occurrence and distribution of emerging pathogens and disease. By definition, One Health has been characterized as a broadly inclusive, collaborative, and transdisciplinary approach with connectivity across local to global scales, which integrates the medical and veterinary community to recognize health outcomes emerging at the environmental nexus for people, animals, plants, and their shared landscapes. One Health has been an incomplete model, conceptually and operationally, focused on reactive and response-based foundations, to limit the impact of emerging pathogens and emerging infectious diseases and, as such, lacks a powerful …

The Microbial Etiology Of Community-Acquired Pneumonia In Adults: From Classical Bacteriology To Host Transcriptional Signatures, Naomi J Gadsby, Daniel M Musher

Faculty, Staff and Students Publications

All modern advances notwithstanding, pneumonia remains a common infection with substantial morbidity and mortality. Understanding of the etiology of pneumonia continues to evolve as new techniques enable identification of already known organisms and as new organisms emerge. We now review the etiology of pneumonia (at present often called "community-acquired pneumonia") beginning with classic bacteriologic techniques, which identified Streptococcus pneumoniae as the overwhelmingly common cause, to more modern bacteriologic studies, which emphasize Haemophilus influenzae, Staphylococcus aureus, Moraxella catarrhalis,

Antibodies Targeting The Neuraminidase Active Site Inhibit Influenza H3n2 Viruses With An S245n Glycosylation Site, Daniel Stadlbauer, Ali H Ellebedy, Et Al.

2020-Current year OA Pubs

Contemporary influenza A H3N2 viruses circulating since 2016 have acquired a glycosylation site in the neuraminidase in close proximity to the enzymatic active site. Here, we investigate if this S245N glycosylation site, as a result of antigenic evolution, can impact binding and function of human monoclonal antibodies that target the conserved active site. While we find that a reduction in the inhibitory ability of neuraminidase active site binders is measurable, this class of broadly reactive monoclonal antibodies maintains protective efficacy in vivo.

Medical School Watercooler Newsletter - December 20, 2022, Lindsey Lyle

Watercooler Newsletter

This is the December 20, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Thakur presents at North American Skull Base Society Annual Meeting
• Faculty Development Grand Rounds to begin Jan. 13
• Basic Medical Sciences students graduate, move on to new labs

2022-12-20_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus/stats/coronavirus-symptoms. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …

Large-Scale Crispri And Transcriptomics Of Staphylococcus Epidermidis Identify Genetic Factors Implicated In Lifestyle Versatility., Michelle Spoto, Johanna P. Riera Puma, Elizabeth Fleming, Changhui Guan, Yvette Ondouah Nzutchi, Dean Kim, Julia Oh

Faculty Research 2022

Staphylococcus epidermidis is a ubiquitous human commensal skin bacterium that is also one of the most prevalent nosocomial pathogens. The genetic factors underlying this remarkable lifestyle plasticity are incompletely understood, mainly due to the difficulties of genetic manipulation, precluding high-throughput functional profiling of this species. To probe the versatility of S. epidermidis to survive across a diversity of environmental conditions, we developed a large-scale CRISPR interference (CRISPRi) screen complemented by transcriptional profiling (RNA sequencing) across 24 diverse conditions and piloted a droplet-based CRISPRi approach to enhance throughput and sensitivity. We identified putative essential genes, importantly revealing amino acid metabolism as …

Examining The Influence Of Information Technology On Health Behaviors And Health Outcomes, Mohammad Moinul Islam Murad

Information Systems & Operations Management Dissertations - Archive

Information Technology (IT) has radically changed our daily lives and it has the potential to help us adopt healthy behaviors and improve health outcomes. This two-part study investigates the influence of IT on health behaviors in population health management. Crises lead to severe uncertainty, high-risk perceptions, and vulnerability among people. Crisis communication through social media platforms influences people to undertake recommended behaviors that mitigate crisis consequences. Political leaders utilize Twitter to deliver crisis messages that offer mental support and empower local communities to spawn resilience and adaptability with emergent collective behaviors necessary to respond to the crisis. The primary objective …

Establishment Of The Invasive Cactus Moth, Cactoblastis Cactorum (Berg) (Lepidoptera: Pyralidae) In Pakistan: A Potential Threat To Cultivated, Ornamental And Wild Opuntia Spp. (Cactaceae), Muhammad Ather Rafi, Harry Pavulaan, Muhammad Islam, Muhammad Ashfaq, Haseeb Kamran, Walija Fayaz, Gul Naz Parveen, Riffat Sultana, Ahmad Zia, Waqar Ahmed, Qudrat Ullah, Muhammad Qasim, Falak Naz, Nazeer Ahmed, Muhammad Tariq Khan, Muhammad Saeed, Jalal Hayat Khan

The Taxonomic Report of the International Lepidoptera Survey

Subsequent to the significant accomplishment of biological control of Opuntia weeds in Australia, the larvae of the cactus moth, Cactoblastis cactorum (native to parts of South America), were released in many countries for the biological control of native Opuntia species (Simmonds and Bennett, 1966). Inauspiciously, larvae were also released in the Caribbean, where the moth spread naturally and by the human support all over the region (García-Turudi et al., 1971). Its enhanced dissemination rate and the biological potential for invasiveness, suggests that the cactus moth is likely to become an invasive pest of Opuntia in the Southeast United States, Mexico, …

Impact Of The Covid-19 Pandemic On College Students And Their Teamwork Abilities, Cameron Garde

Honors Theses

The COVID-19 pandemic left a significant negative impact on the mental health of the world, most notably on traits that affect how people work well with others. Previous research into the effects of the pandemic have found how education has been impacted from the sides of both colleges and students to detract from upper education as a whole. Teamwork and group efforts also ran into unforeseen issues, heavily impacting college students both in the middle of and well past the effects of pandemic restrictions. This thesis uses and analyzes data from a survey disseminated to the University of New Haven …

Covid-19 Newsletter (Vol. 150), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Surveillance Of Antimicrobial Resistance In Veterinary Medicine In The United States: Current E, Juliana M. Ruzante, Beth Harris, Paul Plummer, Raissa R. Raineri, John Dustin Loy, Megan Jacob, Orhan Sahin, Amanda J. Kreuder

Nebraska Center for Virology: Faculty Publications

Antimicrobial resistance (AMR) is a global problem facing human, animal, plant, and environmental health by threatening our ability to effectively treat bacterial infections with antimicrobials. In the United States, robust surveillance efforts exist to collect, analyze, and disseminate AMR data in human health care settings. These tools enable the development of effective infection control methods, the detection of trends, and provide the evidence needed to guide stewardship efforts to reduce the potential for emergence and further spread of AMR. However, in veterinary medicine, there are currently no known equivalent tools. This paper reviews efforts to reduce the potential for emergence …

Arnis-Based Exercise Program For Balance Control In Community-Dwelling Older Adults: Study Protocol For A Pilot Randomized Controlled Trial, Donald Lipardo, Donald Manlapaz, Vergel B. Orpilla, Jim Carlo S. Buan, Jasneer Tricia C. Arevalo, Jaisen Lluch F. Cortez, Kyrell Patrick Desquitado, Vianca Mae L. Geli, Jose Raphael L. Lacorte, Johna R. Masibay, Caitlin Joy A. Sanchez, Alyssa Denise B. Villanueva

Philippine Journal of Physical Therapy

Background: Aging causes impairment in balance and increases the prevalence of falls in older adults. Martial arts are now incorporated into exercise programs to improve balance. Arnis, a Filipino Martial Art, can improve the balance control of older adults.

Objectives: This study primarily aims to determine the effects of an Arnis-based exercise program on balance control of healthy community-dwelling older adults. This study also aims to describe its effect on older adults’ concerns about falling and lower limb functional strength.

Methods:This will be a single-blind, pilot randomized controlled trial. Participants will be randomly allocated to either the intervention or …

The Impact Of The Covid-19 Outbreak On The Weak-Form Informational Efficiency Of The Warsaw Stock Exchange, Jacek Karasiński

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

The aim of this paper is to verify whether the COVID-19 outbreak negatively affected the weak-form informational efficiency of the Warsaw Stock Exchange (WSE). Applying a wild bootstrapped automatic variance ratio test and the rolling window methodology, we verify the martingale hypothesis for daily returns of 437 stocks listed on the Main Market of the WSE i n a research period beginning on January 2nd, 2015 and ending on August 31st, 2020. The percentage of cases in which the martingale hypothesis cannot be rejected is our proxy for the weak-form informational efficiency that we come up with. Despite the rapid …

Surveillance Of Antimicrobial Resistance In Veterinary Medicine In The United States: Current Efforts, Challenges, And Opportunities, Juliana M. Ruzante, Beth Harris, Paul Plummer, Raissa R. Raineri, John Dustin Loy, Megan Jacob, Orhan Sahin, Amanda J. Kreuder

School of Veterinary and Biomedical Sciences: Faculty Publications

Antimicrobial resistance (AMR) is a global problem facing human, animal, plant, and environmental health by threatening our ability to effectively treat bacterial infections with antimicrobials. In the United States, robust surveillance efforts exist to collect, analyze, and disseminate AMR data in human health care settings. These tools enable the development of effective infection control methods, the detection of trends, and provide the evidence needed to guide stewardship efforts to reduce the potential for emergence and further spread of AMR. However, in veterinary medicine, there are currently no known equivalent tools. This paper reviews efforts to reduce the potential for emergence …

Strategic Perspective Of Leveraging New Generation Information Technology To Enable Modernization Of Emergency Management, Haibo Zhang, Xinyu Dai, Depei Qian, Jian Lyu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The application and development of the new generation information technology is a vital support to realize the modernization of emergency management. At present, the new generation information technology such as big data and artificial intelligence has been widely used in natural disasters, safe production, and other fields. It has improved the monitoring and early warning, regulation and law enforcement, command and decision support, rescue, and social mobilization capabilities of governments, promoted the level of intrinsic safety of enterprises, provided important support for the precise prevention and control of the COVID-19, and increased the efficiency of China’s emergency management and sense …

Nature Of Β-1,3-Glucan-Exposing Features On Candida Albicans Cell Wall And Their Modulation, Leandro Jose De Assis, Jm Bain, C Liddle, I Leaves, C Hacker, Da Silva R Peres, R Yuecel, A Bebes, D Stead, Ds Childers, A Pradhan, K Mackenzie, K Lagree, De Larcombe, Q Ma, Gm Avelar, Mg Netea, Lp Erwig, Ap Mitchell, Gd Brown, Nar Gow, Ajp Brown

Peninsula Medical School

Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign” and used to activate protective immunity.

Type Iv Pili Are A Critical Virulence Factor In Clinical Isolates Of Paenibacillus Thiaminolyticus, Christine Hehnly, Petra Erdmann Gilmore, R. Reid Townsend, David D. Limbrick, Et Al.

2020-Current year OA Pubs

Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hydrocephalus in these areas. Since many children with hydrocephalus suffer poor long-term outcomes despite surgical intervention, prevention of hydrocephalus remains paramount. Our previous studies implicated a novel bacterial pathogen, Paenibacillus thiaminolyticus, as a causal agent of neonatal sepsis and postinfectious hydrocephalus in Uganda. Here, we report the isolation of three

Self-Hybridization In Leishmania Major, Tiago R Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, David Sacks

2020-Current year OA Pubs

Genetic exchange between different

The Role Of Lncrnas In The Tumor Microenvironment And Immunotherapy Of Melanoma, Wencheng Zhou, Xuewen Xu, Ying Cen, Junjie Chen

Faculty, Staff and Student Publications

Melanoma is one of the most lethal tumors with highly aggressive and metastatic properties. Although immunotherapy and targeted therapy have certain therapeutic effects in melanoma, a significant proportion of patients still have drug resistance after treatment. Recent studies have shown that long noncoding RNAs (lncRNAs) are widely recognized as regulatory factors in cancer. They can regulate numerous cellular processes, including cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) progression and the immune microenvironment. The role of lncRNAs in malignant tumors has received much attention, whereas the relationship between lncRNAs and melanoma requires further investigation. Our review summarizes tumor suppressive and oncogenic lncRNAs …

Antibody Epitope Profiling Of The Kshv Lana Protein Using Virscan, Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood

School of Biological Sciences: Faculty Publications

The humoral antibody response against Kaposi sarcoma-associated herpesvirus (KSHV) in infected individuals has been characterized demonstrating the latency-associated nuclear antigen (LANA) as the most antigenic KSHV protein. Despite the antigenicity of the protein, specific LANA epitopes have not been systematically characterized. Here, we utilized a bacteriophage T7 library, which displays 56-amino acid KSHV LANA peptides with 28-amino acid overlap (VirScan), to define those epitopes in LANA targeted by antibodies from a cohort of 62 sub-Saharan African Kaposi sarcoma (KS) patients and 22 KSHV-infected asymptomatic controls. Intra- and inter-patient breadth and magnitude of the anti-LANA responses were quantified at the peptide …