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The Impact Of Covid-19 Quarantine On Lifestyle Indicators In The United Arab Emirates, Sharifa Alblooshi, Maryam Alfalasi, Zainab Taha, Farid El Ktaibi, Alia Khalid Jan 2023

The Impact Of Covid-19 Quarantine On Lifestyle Indicators In The United Arab Emirates, Sharifa Alblooshi, Maryam Alfalasi, Zainab Taha, Farid El Ktaibi, Alia Khalid

All Works

Introduction: COVID-19 is a virus that has spread rapidly and brought economic and social crises all around the world. The current study aimed to investigate the impact of COVID-19 quarantine on dietary habits, physical activity, food purchasing, smoking, and sleeping patterns in the United Arab Emirates. Methods: A cross-sectional study was conducted using an online questionnaire between November 1st, 2020 and the end of January 2021. Citizens and residents of the UAE aged ≥ 18 years old were asked to complete an anonymous electronic questionnaire created via Google Forms and distributed on various platforms, such as WhatsApp, Twitter, and email. …


Consolidating Port Decarbonisation Implementation : Concept, Pathways, Barriers, Solutions, And Opportunities, A.S. Alamoush, D. Dalaklis, F. Ballini, A.I. Ölcer Jan 2023

Consolidating Port Decarbonisation Implementation : Concept, Pathways, Barriers, Solutions, And Opportunities, A.S. Alamoush, D. Dalaklis, F. Ballini, A.I. Ölcer

Articles

No abstract provided.


Examining An Information System (Is) Solution To Increase Uk University Students’ Engagement During Lecturing Activities, A. Dalaklis, A. Dalaklis, D. Dalaklis Jan 2023

Examining An Information System (Is) Solution To Increase Uk University Students’ Engagement During Lecturing Activities, A. Dalaklis, A. Dalaklis, D. Dalaklis

Articles

No abstract provided.


Graduate Catalog 2023-2024, Southwestern Oklahoma State University Jan 2023

Graduate Catalog 2023-2024, Southwestern Oklahoma State University

Graduate Catalogs

No abstract provided.


Lactobacillus Metabolite Nc As An Inflammation Inhibitor, Drew Hahnnah Landrowski Jan 2023

Lactobacillus Metabolite Nc As An Inflammation Inhibitor, Drew Hahnnah Landrowski

Master's Theses

The human body contains a diverse ecosystem of microbes. Commensal bacteria have numerous mutually-beneficial relationships with their host. Not only do they assist in digestion and gut homeostasis, they are critical for development and function of the immune system. As such, hosts and microbes alike have evolved mechanisms to foster symbiosis. Gut barrier function, toll-like receptor signaling, and metabolites are all examples of how hosts interact with microbes to promote this mutually-beneficial relationship. Metabolites from commensal bacteria promote the generation of regulatory T-cells, capable of ameliorating inflammation. A number of inflammatory, allergic, and autoimmune conditions are associated with dysbiosis. Therefore, …


Decolonizing A Settler Colonial State: How Canada And The United States Have Approached Investigations Into Indigenous Boarding And Residential Schools, Holly Jacobs Jan 2023

Decolonizing A Settler Colonial State: How Canada And The United States Have Approached Investigations Into Indigenous Boarding And Residential Schools, Holly Jacobs

Master's Theses

Indigenous boarding and residential schools were in use for over 100 years in both Canada and the United States. Grown from numerous policies aimed at assimilation, dispossession, and genocide of the Indigenous peoples of North America, these residential schools had a particular aim: to wipe away all cultural and familial ties of every individual and to replace them with beliefs and values of white settlers. Though the schools are no longer in operation, their legacy of erasure and pain continues to affect survivors, their descendants, and Indigenous communities across both nations. This thesis looks at what the federal governments of …


Fostering A High-Functioning Team In Cancer Care Using The 4r Oncology Model: Assessment In A Large Health System And A Blueprint For Other Institutions, Raymond Liu, Christine B Weldon, Elizabeth Linehan, Nancy Gordon, Thea Abbe, Marti Hennings, Henie James, Jed Katzel, Chun Ng, Megumi Tomita, Jeffrey B Velotta, Stephanie Ossowski, Lori C Sakoda, Sharon Likely Sprague, Anna Dowling, Kimberly Beringer, Arliene Ravelo, Elaine Yu, Julia R Trosman Jan 2023

Fostering A High-Functioning Team In Cancer Care Using The 4r Oncology Model: Assessment In A Large Health System And A Blueprint For Other Institutions, Raymond Liu, Christine B Weldon, Elizabeth Linehan, Nancy Gordon, Thea Abbe, Marti Hennings, Henie James, Jed Katzel, Chun Ng, Megumi Tomita, Jeffrey B Velotta, Stephanie Ossowski, Lori C Sakoda, Sharon Likely Sprague, Anna Dowling, Kimberly Beringer, Arliene Ravelo, Elaine Yu, Julia R Trosman

Faculty, Staff and Student Publications

PURPOSE: Delivering cancer care by high-functioning multidisciplinary teams promises to address care fragmentation, which threatens care quality, affects patient outcomes, and strains the oncology workforce. We assessed whether the 4R Oncology model for team-based interdependent care delivery and patient self-management affected team functioning in a large community-based health system.

METHODS: 4R was deployed at four locations in breast and lung cancers and assessed along four characteristics of high-functioning teams: recognition as a team internally and externally; commitment to an explicit shared goal; enablement of interdependent work to achieve the goal; and engagement in regular reflection to adapt objectives and processes. …


A Case Of Successful Treatment Of Recurrent Urinary Tract Infection By Extended-Spectrum Β-Lactamase Producing Klebsiella Pneumoniae Using Oral Lyophilized Fecal Microbiota Transplant, Naomi Bier, Blake Hanson, Zhi-Dong Jiang, Herbert L Dupont, Cesar A Arias, William R Miller Jan 2023

A Case Of Successful Treatment Of Recurrent Urinary Tract Infection By Extended-Spectrum Β-Lactamase Producing Klebsiella Pneumoniae Using Oral Lyophilized Fecal Microbiota Transplant, Naomi Bier, Blake Hanson, Zhi-Dong Jiang, Herbert L Dupont, Cesar A Arias, William R Miller

Faculty, Staff and Student Publications

Recurrent urinary tract infections (UTIs) are a challenging clinical entity that can be frustrating for patient and physician alike. Repeated rounds of antibiotics can select for multidrug-resistant organisms, further complicating care. We describe the successful use of fecal microbiota transplantation (FMT) for the treatment of recurrent extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae UTIs in a patient with an ileal conduit and urostomy. In the 18 months after FMT, the patient had not experienced new infections with ESBL-producing organisms. The urine and stool microbiomes of the patient were tracked before and post-FMT using 16s RNA sequencing with measurement of α-diversity. Sequencing of …


Nurses’ Perceptions Of The Skills, Knowledge And Attributes Required To Optimise Scope Of Practice And Improve Access To Care For People Experiencing Homelessness In Australia: A Cross-Sectional Study, Jane Currie, Lucy Mcwilliams, Martha Paisi, Jill Shawe, Anna Thornton, Matthew Larkin, Joanne Taylor, Sandy Middleton Jan 2023

Nurses’ Perceptions Of The Skills, Knowledge And Attributes Required To Optimise Scope Of Practice And Improve Access To Care For People Experiencing Homelessness In Australia: A Cross-Sectional Study, Jane Currie, Lucy Mcwilliams, Martha Paisi, Jill Shawe, Anna Thornton, Matthew Larkin, Joanne Taylor, Sandy Middleton

School of Nursing and Midwifery

Background People experiencing homelessness are less likely to access healthcare, particularly primary and preventive care. Nurses are well placed to improve access to healthcare for this vulnerable population. Aim To explore nurses’ perceptions of the skills, knowledge and attributes required to optimise scope of practice and improve access to healthcare for people experiencing homelessness, to underpin an education framework. Design A cross-sectional national survey of nurses in Australia. Methods Part of a larger study, a 222-item electronic survey was disseminated via social media and nursing colleges and associations. Participants rated the level of priority of specific skills knowledge and attributes …


Development And Validation Of Early Death Risk Score Model For Emergency Status Prediction In Very Severe Aplastic Anemia, Xu Liu, Wenrui Yang, Li Zhang, Liping Jing, Lei Ye, Kang Zhou, Yuan Li, Jianping Li, Huihui Fan, Yang Yang, Youzhen Xiong, Xin Zhao, Fengkui Zhang Jan 2023

Development And Validation Of Early Death Risk Score Model For Emergency Status Prediction In Very Severe Aplastic Anemia, Xu Liu, Wenrui Yang, Li Zhang, Liping Jing, Lei Ye, Kang Zhou, Yuan Li, Jianping Li, Huihui Fan, Yang Yang, Youzhen Xiong, Xin Zhao, Fengkui Zhang

Faculty, Staff and Student Publications

This study developed and validated the Early Death Risk Score Model for early identification of emergency patients with very severe aplastic anemia (VSAA). All 377 patients with VSAA receiving first-line immunosuppressive therapy (IST) were categorized into training (n=252) and validation (n=125) cohorts. In the training cohort, age >24 years, absolute neutrophil count ≤0.015×109/L, serum ferritin >900ng/mL and times of fever before IST >1 time were significantly associated with early death. Covariates were assigned scores and categorized as: low (score 0-4), medium (score 5-7) and high (score ≥8) risk. Early death rate was significantly different between risk groups and the validation …


Super-Resolution And Segmentation Deep Learning For Breast Cancer Histopathology Image Analysis, Aniwat Juhong, Bo Li, Cheng-You Yao, Chia-Wei Yang, Dalen W Agnew, Yu Leo Lei, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu Jan 2023

Super-Resolution And Segmentation Deep Learning For Breast Cancer Histopathology Image Analysis, Aniwat Juhong, Bo Li, Cheng-You Yao, Chia-Wei Yang, Dalen W Agnew, Yu Leo Lei, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu

Faculty, Staff and Student Publications

Traditionally, a high-performance microscope with a large numerical aperture is required to acquire high-resolution images. However, the images' size is typically tremendous. Therefore, they are not conveniently managed and transferred across a computer network or stored in a limited computer storage system. As a result, image compression is commonly used to reduce image size resulting in poor image resolution. Here, we demonstrate custom convolution neural networks (CNNs) for both super-resolution image enhancement from low-resolution images and characterization of both cells and nuclei from hematoxylin and eosin (H&E) stained breast cancer histopathological images by using a combination of generator and discriminator …


Risk Factors Associated With Severe Clostridioides Difficile Infection In Patients With Cancer, Denise Marie A Francisco, Liangliang Zhang, Ying Jiang, Adilene Olvera, Javier Adachi, Eduardo Yepez Guevara, Samuel L Aitken, Kevin W Garey, Christine B Peterson, Kim-Anh Do, Ryan Dillon, Engels N Obi, Robert Jenq, Pablo C Okhuysen Jan 2023

Risk Factors Associated With Severe Clostridioides Difficile Infection In Patients With Cancer, Denise Marie A Francisco, Liangliang Zhang, Ying Jiang, Adilene Olvera, Javier Adachi, Eduardo Yepez Guevara, Samuel L Aitken, Kevin W Garey, Christine B Peterson, Kim-Anh Do, Ryan Dillon, Engels N Obi, Robert Jenq, Pablo C Okhuysen

Faculty, Staff and Student Publications

INTRODUCTION: Antibiotic use is a risk factor for Clostridioides difficile infection (CDI). Few studies have correlated use of prior antibiotic classes with CDI, microbiome composition, and disease severity in patients with cancer. We hypothesized that previous antibiotic exposure and fecal microbiome composition at time of presentation are risk factors for severe CDI in patients with cancer.

METHODS: This non-interventional, prospective, cohort study examined 200 patients with cancer who had their first episode or first recurrence of CDI. C. difficile was identified using nucleic acid amplification testing. Univariate analysis was used to determine significant risk factors for severe CDI. Fecal microbiome …


The Interplay Between Neoantigens And Immune Cells In Sarcomas Treated With Checkpoint Inhibition, Irantzu Anzar, Brandon Malone, Pubudu Samarakoon, Ioannis Vardaxis, Boris Simovski, Hugues Fontenelle, Leonardo A Meza-Zepeda, Richard Stratford, Emily Z Keung, Melissa Burgess, Hussein A Tawbi, Ola Myklebost, Trevor Clancy Jan 2023

The Interplay Between Neoantigens And Immune Cells In Sarcomas Treated With Checkpoint Inhibition, Irantzu Anzar, Brandon Malone, Pubudu Samarakoon, Ioannis Vardaxis, Boris Simovski, Hugues Fontenelle, Leonardo A Meza-Zepeda, Richard Stratford, Emily Z Keung, Melissa Burgess, Hussein A Tawbi, Ola Myklebost, Trevor Clancy

Faculty, Staff and Student Publications

INTRODUCTION: Sarcomas are comprised of diverse bone and connective tissue tumors with few effective therapeutic options for locally advanced unresectable and/or metastatic disease. Recent advances in immunotherapy, in particular immune checkpoint inhibition (ICI), have shown promising outcomes in several cancer indications. Unfortunately, ICI therapy has provided only modest clinical responses and seems moderately effective in a subset of the diverse subtypes.

METHODS: To explore the immune parameters governing ICI therapy resistance or immune escape, we performed whole exome sequencing (WES) on tumors and their matched normal blood, in addition to RNA-seq from tumors of 31 sarcoma patients treated with pembrolizumab. …


The Department Of Transportation’S Failures In Regulating Emotional Support Animals, Jillian Doughty Jan 2023

The Department Of Transportation’S Failures In Regulating Emotional Support Animals, Jillian Doughty

Journal of Air Law and Commerce

In the past decade, the number of emotional support animals being used to treat a wide array of mental and emotional disorders has multiplied exponentially. This increase has been met with mixed reactions in the context of air travel. While some passengers are thrilled to sit next to a dog on their flight, others are frustrated due to the belief passengers with emotional support animals are exploiting a loophole to travel with their pet for free. Regardless of the differing perceptions, emotional support animals are a valid, affordable way to treat mental health illnesses without incurring negative side effects associated …


Identification And Creation Of Novel Bacteriocins With Potential Food And Clinical Applications, David Lynch Jan 2023

Identification And Creation Of Novel Bacteriocins With Potential Food And Clinical Applications, David Lynch

Theses

Bacteriocins represent a heterogeneous group of small, ribosomal-synthesized, potent antibacterial peptides produced by bacteria, capable of inhibiting bacteria both closely related or indeed those from other genera than the producer. In addition to their role as food preservatives, bacteriocins have potent activity against medically significant pathogens and are considered attractive alternatives to antibiotics, due to their inherent heat stability, potency at nanomolar scale, resistance to proteases and low levels of acquired resistance in commercial applications. The aim of this thesis was to identify, purify and bioengineer novel bacteriocins from Staphylococcus and Lactic Acid Bacteria (LAB), with a view to expanding …


Assessment Of Biosecurity Practices Adoption In Broiler Farms In East Africa: Case Study Of Pwani Region In Tanzania, Rogia Saïdath Adéline Gomez Jan 2023

Assessment Of Biosecurity Practices Adoption In Broiler Farms In East Africa: Case Study Of Pwani Region In Tanzania, Rogia Saïdath Adéline Gomez

All Rsif Scholars' Publications

Broiler farming in Tanzania is an important poultry sub-sector, providing employment and the much-de- manded meat hence, contributing to the income and nutrition of the population. However, for small to medium-scale producers the profitability has been hampered by high incidences of diseases and costs associated with their control. This study aimed to assess the biosecurity practices adopted by broiler farmers in the Pwani region, Tanzania. A struc- tured questionnaire was administered to 78 broiler farmers complemented with on-site observations. Data collected were related to the socio-demographic characteristics, the structure of broiler farms, the level of biosecurity in the farms as …


Genetic Diversity Of Newcastle Disease Virus Involved In The 2021 Outbreaks In Backyard Poultry Farms In Tanzania, Charlie Frank Arthur N'Guessan Amoia, Jean N. Hakizimana, Nisha K. Duggal, Augustino A. Chengula, Mohammed A. Rohaim, Muhammad Munir, James Weger-Lucarelli, Gerald Misinzo Jan 2023

Genetic Diversity Of Newcastle Disease Virus Involved In The 2021 Outbreaks In Backyard Poultry Farms In Tanzania, Charlie Frank Arthur N'Guessan Amoia, Jean N. Hakizimana, Nisha K. Duggal, Augustino A. Chengula, Mohammed A. Rohaim, Muhammad Munir, James Weger-Lucarelli, Gerald Misinzo

All Rsif Scholars' Publications

Newcastle disease virus is a significant avian pathogen with the potential to decimate poultry populations all over the world and cause enormous economic losses. Distinct NDV genotypes are currently causing outbreaks worldwide. Due to the high genetic diversity of NDV, virulent strains that may result in a lack of vaccine protection are more likely to emerge and ultimately cause larger epidemics with massive economic losses. Thus, a more comprehensive understanding of the circulating NDV genotypes is critical to reduce Newcastle disease (ND) burden. In this study, NDV strains were isolated and characterized from backyard poultry farms from Tanzania, East Africa …


Bushmeat Consumption In Africa: A Microbiological Safety Challenge?, Gwladys Gloria Amen Ahouanse, Abdulsudi Issa-Zacharia, Nuria Majaliwa Jan 2023

Bushmeat Consumption In Africa: A Microbiological Safety Challenge?, Gwladys Gloria Amen Ahouanse, Abdulsudi Issa-Zacharia, Nuria Majaliwa

All Rsif Scholars' Publications

Objective: This review analyzed the microbiological safety of bushmeat consumed in Africa over the past decades. Methodology:Previous Studies mainly focused on large animals like antelopes and smaller ones like grasscutter. Most microbes studied were similar to those in domestic animal meat, except for rare pathogens such as Salmonella spp, E.coli. Sampling, experiments, and microbe prevalence varied among studies.Results:All studies confirmed the presence of zoonotic pathogens dangerous to human beings. Therefore, more investigations are needed, especially for the chronic and severe cases of pathogens, since only few studies have addressed the bushmeat's microbiological safety in Africa. Conclusion:Efforts should be made to …


Bauhinia Rufescens, Ocimum Basilicum And Salvadora Persica: A Review Of Their Chemical Compounds And Properties For Antimicrobial, Antioxidant And Cytotoxicity, Hissein Hassan Abdel-Razakh, Gaymary George Bakari, Cheol-Ho Pan, Abubakar Shaaban Hoza Jan 2023

Bauhinia Rufescens, Ocimum Basilicum And Salvadora Persica: A Review Of Their Chemical Compounds And Properties For Antimicrobial, Antioxidant And Cytotoxicity, Hissein Hassan Abdel-Razakh, Gaymary George Bakari, Cheol-Ho Pan, Abubakar Shaaban Hoza

All Rsif Scholars' Publications

Bauhinia rufescens, Ocimum basilicum and Salvadora persica are well known plants used in African traditional medicine, especially in Chadian traditional medicine. They are mostly used in the treatment of infectious diseases, inflammatory diseases, fever, and so on. Studies using various in vitro and in vivo bioassay techniques support the scientific rationale for most of these usages. In this review, ethnobotanical uses, chemistry of natural products, and pharmacological and clinical data for these plants are presented


Molecular Epidemiological Survey Of Pathogenic Trypanosomes In Naturally Infected Cattle In Northern Côte D’Ivoire., Jean-Yves Ekra, Edouard K. N’Goran, Leonard E.G Mboera, Biégo Guillaume Gragnon, Koco Rita Nadège Assovié, Eliakunda Michael Mafie Jan 2023

Molecular Epidemiological Survey Of Pathogenic Trypanosomes In Naturally Infected Cattle In Northern Côte D’Ivoire., Jean-Yves Ekra, Edouard K. N’Goran, Leonard E.G Mboera, Biégo Guillaume Gragnon, Koco Rita Nadège Assovié, Eliakunda Michael Mafie

All Rsif Scholars' Publications

ovine trypanosomiasis is a significant health concern for livestock intensification in Côte d’Ivoire. This study aimed to determine the prevalence and distribution of pathogenic trypanosomes and identify the most infected cattle breed in northern Côte d'Ivoire. We examined 700 cattle and found that polymerase chain reaction (PCR) was more sensi- tive (12.3%) than microscopic observation (5.6%). Among the trypanosome species de- tected in naturally infected cattle, Trypanosoma vivax was 7.3%, Trypanosoma simiae tsavo was 6.7%, and Trypanosoma congolense was 0.4%. The overall prevalence of trypanosome infection in all cattle breeds was 12.3%, while the prevalence in individual breeds was 14.8%, …


Prevalence Of Bovine Trypanosomiasis In Côte D’Ivoire: Systematic Review And Meta-Analysis, Jean-Yves Ekra, Edouard K. N’Goran, Léonard E.G Mboera, Eliakunda M. Mafie Jan 2023

Prevalence Of Bovine Trypanosomiasis In Côte D’Ivoire: Systematic Review And Meta-Analysis, Jean-Yves Ekra, Edouard K. N’Goran, Léonard E.G Mboera, Eliakunda M. Mafie

All Rsif Scholars' Publications

Bovine trypanosomiasis is a parasitic disease caused by protozoans of the genus Trypanosoma . The disease cause economic losses in livestock production. In order to determine the status of research on this disease in Côte d’Ivoire, we used the systematic review method and meta-analysis. Three electronics databases, namely Google Scholar, PubMed and CrossRef were used to search for publications on trypanosomiasis prevalence that met our inclusion criteria. Twenty five articles were identified, 11 of which met the inclusion criteria. Bovine trypanosomiasis prevalence of 2.99% (95% confidence interval [CI]: 2.96% – 3.01%) to 25.28% (95% CI: 25.17% – 25.38%) were recorded …


Heat Stress Effects On Milk Yield Traits And Metabolites And Mitigation Strategies For Dairy Cattle Breeds Reared In Tropical And Sub-Tropical Countries, Vincent Habimana, Athumani Nguluma, Zabron Cuthibert Nziku, Gota Morota, Raphael Mrode, Sebastian Chenyambuga Jan 2023

Heat Stress Effects On Milk Yield Traits And Metabolites And Mitigation Strategies For Dairy Cattle Breeds Reared In Tropical And Sub-Tropical Countries, Vincent Habimana, Athumani Nguluma, Zabron Cuthibert Nziku, Gota Morota, Raphael Mrode, Sebastian Chenyambuga

All Rsif Scholars' Publications

Heat stress is an important problem for dairy industry in many parts of the world owing to its adverse effects on productivity and profitability. Heat stress in dairy cattle is caused by an increase in core body temperature, which affects the fat production in the mammary gland. It reduces milk yield, dry matter intake, and alters the milk composition, such as fat, protein, lactose, and solids-not-fats percentages among others. Understanding the biological mechanisms of climatic adaptation, identifying and exploring signatures of selection, genomic diversity and identification of candidate genes for heat tolerance within indicine and taurine dairy breeds is an …


Genes And Models For Estimating Genetic Parameters For Heat Tolerance In Dairy Cattle, Vincent Habimana, Chinyere Charlotte Ekine-Dzivenu, Athumani Shabani Nguluma, Zabron Cuthibert Nziku, Gota Morota, Sebastian Wilson Chenyambuga, Raphael Mrode Jan 2023

Genes And Models For Estimating Genetic Parameters For Heat Tolerance In Dairy Cattle, Vincent Habimana, Chinyere Charlotte Ekine-Dzivenu, Athumani Shabani Nguluma, Zabron Cuthibert Nziku, Gota Morota, Sebastian Wilson Chenyambuga, Raphael Mrode

All Rsif Scholars' Publications

Dairy cattle are highly susceptible to heat stress. Heat stress causes a decline in milk yield, reduced dry matter intake, reduced fertility rates, and alteration of physiological traits (e.g., respiration rate, rectal temperature, heart rates, pulse rates, panting score, sweating rates, and drooling score) and other biomarkers (oxidative heat stress biomarkers and stress response genes). Considering the significant effect of global warming on dairy cattle farming, coupled with the aim to reduce income losses of dairy cattle farmers and improve production under hot environment, there is a need to develop heat tolerant dairy cattle that can grow, reproduce and produce …


Microparticles As Viral Rna Carriers From Stool For Stable And Sensitive Surveillance, Emmanuel Kifaro, Mi Jung Kim, Seungwon Jung, Yoon-Ha Jang, Sungyeon Moon, Dong-Hun Lee, Chang-Seon Song, Gerald Misinzo, Sang Kyung Kim Jan 2023

Microparticles As Viral Rna Carriers From Stool For Stable And Sensitive Surveillance, Emmanuel Kifaro, Mi Jung Kim, Seungwon Jung, Yoon-Ha Jang, Sungyeon Moon, Dong-Hun Lee, Chang-Seon Song, Gerald Misinzo, Sang Kyung Kim

All Rsif Scholars' Publications

Since its discovery, polymerase chain reaction (PCR) has emerged as an important technol- ogy for the diagnosis and identification of infectious diseases. It is a highly sensitive and reliable nucleic acids (NA) detection tool for various sample types. However, stool, which carries the most abundant micro-organisms and physiological byproducts, remains to be the trickiest clinical specimen for molecular detection of pathogens. Herein, we demonstrate the novel application of hydrogel mi- croparticles as carriers of viral RNA from stool samples without prior RNA purification for real-time polymerase chain reaction (qPCR). In each microparticle of primer-incorporated network (PIN) as a self-sufficient reaction …


Small Molecule Inhibitor Of Tau Self-Association In A Mouse Model Of Tauopathy: A Preventive Study In P301l Tau Jnpl3 Mice, Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Moe Jan 2023

Small Molecule Inhibitor Of Tau Self-Association In A Mouse Model Of Tauopathy: A Preventive Study In P301l Tau Jnpl3 Mice, Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Moe

Faculty, Staff and Student Publications

Advances in tau biology and the difficulties of amyloid-directed immunotherapeutics have heightened interest in tau as a target for small molecule drug discovery for neurodegenerative diseases. Here, we evaluated OLX-07010, a small molecule inhibitor of tau self-association, for the prevention of tau aggregation. The primary endpoint of the study was statistically significant reduction of insoluble tau aggregates in treated JNPL3 mice compared with Vehicle-control mice. Secondary endpoints were dose-dependent reduction of insoluble tau aggregates, reduction of phosphorylated tau, and reduction of soluble tau. This study was performed in JNPL3 mice, which are representative of inherited forms of 4-repeat tauopathies with …


Pediatric Diarrhea Patients Living In Urban Areas Have A Higher Incidence Of Clostridioides Difficile Infection, Ayodele T Adesoji, Osaro Mgbere, Charles Darkoh Jan 2023

Pediatric Diarrhea Patients Living In Urban Areas Have A Higher Incidence Of Clostridioides Difficile Infection, Ayodele T Adesoji, Osaro Mgbere, Charles Darkoh

Faculty, Staff and Student Publications

Clostridioides difficile infection (CDI) is a major cause of antibiotic-associated diarrhea and an unappreciated contributor to child mortality in low- and middle-income countries where the diagnosis may be difficult. There is little information about the prevalence of CDI among infants, children, and adolescents in Africa. Using a cross-sectional design, seventy-six samples were collected from pediatric patients presenting with diarrhea, including infants (≤ 2 years old), children (2-12 years), and adolescents (13 ≤17 years) from three hospitals between January and December 2019. Demographic data, medical history, and prior antibiotic use were recorded. Toxigenic culture and PCR were used to detect and …


Population-Based Assessment Of The Burden Of Covid-19 Infection In African Countries: A First-Year Report Card And Public Health Implications, Osaro Mgbere, Ogbonna Collins Nwabuko, Olajumoke A Olateju, Omolola E Adepoju, Winston Liaw, Charles Darkoh, Ekere James Essien Jan 2023

Population-Based Assessment Of The Burden Of Covid-19 Infection In African Countries: A First-Year Report Card And Public Health Implications, Osaro Mgbere, Ogbonna Collins Nwabuko, Olajumoke A Olateju, Omolola E Adepoju, Winston Liaw, Charles Darkoh, Ekere James Essien

Faculty, Staff and Student Publications

BACKGROUND: The COVID-19 pandemic constitutes a global health threat and poses a major burden on the African continent. We assessed the real-world burden of COVID-19 infection in African Union (AU) member states to determine the distributional patterns of epidemiological measures during the first 1 year of the pandemic.

METHODS: This retrospective cross-sectional study utilized COVID-19 data from publicly available data repositories of the African Center for Disease Control and Prevention and

RESULTS: A total of 3.21 million cases were reported during the 1-year period, with 2.6 million recoveries, 536,784 cases remaining active, and 77,486 deaths. Most countries (49.1%,

CONCLUSION: Understanding …


Evolutionary Aspects Of Infections: Inflammation And Sickness Behaviors, Robert Dantzer Jan 2023

Evolutionary Aspects Of Infections: Inflammation And Sickness Behaviors, Robert Dantzer

Faculty, Staff and Student Publications

Sickness behavior was conceptualized initially as the behavioral counterpart of the fever response to infectious pathogens. It helps to raise body temperature to its higher setpoint and to maintain it at this new level and it has the additional benefit of enabling a weakened organism to protect itself from other dangers. The discovery of the behavioral effects of proinflammatory cytokines produced by activated immune cells provided a cellular and molecular basis to this phenomenon. The administration of cytokines or cytokine inducers like lipopolysaccharide to healthy rodents allowed to reveal the similarities and differences between inflammation-induced sickness behavior and the fever …


Molecular Detection Of Canine And Feline Hemotropic Mycoplasmas In Northern Vietnam, Bui Thi Huyen Thuong Jan 2023

Molecular Detection Of Canine And Feline Hemotropic Mycoplasmas In Northern Vietnam, Bui Thi Huyen Thuong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hemoplasma is commonly used to refer to hemotropic Mycoplasma bacterial species belonging to the genus Mycoplasma that can attach to the surface of red blood cells, potentially leading to hemolytic anemia. These organisms can infect a wide range of mammals, including companion animals and humans worldwide. Specifically for companion animals, two main hemoplasma species can infect dogs, and three major species can infect cats including Mycoplasma haemocanis, Candidatus Mycoplasma haematoparvum, Mycoplasma haemofelis, Candidatus Mycoplasma haemominutum, and Candidatus Mycoplasma turicensis, respectively. Currently, there is a lack of research data regarding hemoplasma infections in dogs and cats in Vietnam. Therefore, this study …


A Comparative Analysis Of Medical Malpractice Law In Telemedicine Between Thailand And Germany, Surusvadee Viravud Jan 2023

A Comparative Analysis Of Medical Malpractice Law In Telemedicine Between Thailand And Germany, Surusvadee Viravud

Chulalongkorn University Theses and Dissertations (Chula ETD)

ในประเทศไทยและเยอรมนี การแพทย์ทางไกลได้กลายเป็นส่วนสำคัญในการดูแลสุขภาพของประชาชนทั่วไป การบริการทางการแพทย์นี้มีความสำคัญอย่างยิ่งหลังการแพร่ระบาดของโรคโควิด-19 ไปทั่วโลก การบริการการแพทย์ทางไกลมีประโยชน์หลายประการทั้งการเข้าถึงการบริการด้านสุขภาพที่เพิ่มมากขึ้น ตลอดจนส่งเสริมความสามารถในการให้บริการด้านสุขภาพของผู้ให้บริการทางการแพทย์ อย่างไรก็ตาม การแพทย์ทางไกลได้ก่อให้เกิดความท้าทายทางด้านกฎหมาย โดยเฉพาะประเด็นที่เกี่ยวข้องกับเรื่องการทุรเวชปฏิบัติทางการแพทย์ทางไกลโดยเจ้าหน้าที่ทางการแพทย์และผู้ให้บริการการแพทย์ทางไกลซึ่งมีรูปแบบและลักษณะแตกต่างจากการให้บริการทางการแพทย์แบบดั้งเดิมปัจจุบัน การให้บริการการแพทย์ทางไกลโดยแพทย์ที่ได้รับใบอนุญาตนั้นจะต้องทำตามหลักเกณฑ์ตามประกาศแพทยสภา ฉบับที่ 54/2563 ซึ่งได้กำหนดความหมายของคำว่า “การแพทย์ทางไกล" ไว้เป็นการเฉพาะ และยังปรากฏว่ามีออกประกาศกระทรวงสาธารณสุขเรื่องมาตรฐานสำหรับสถานพยาบาลที่ใช้ระบบบริการการแพทย์ทางไกล พ.ศ. 2564 เพื่อกำกับดูแลการให้บริการการแพทย์ทางไกลของผู้ให้บริการสถานพยาบาล อย่างไรก็ตาม ยังไม่ปรากฏว่ามีกฎหมายที่เกี่ยวข้องกับการเรียกค่าสินไหมทดแทนจากทุรเวชปฏิบัติด้านการแพทย์ทางไกลไว้โดยเฉพาะเจาะจง การบาดเจ็บที่เกิดจากการกระทำทุรเวชปฏิบัติทางการแพทย์ที่เกิดขึ้นในกรณีการแพทย์ทางไกลจะอยู่ภายใต้มาตรา 420 ของประมวลกฎหมายแพ่งและพาณิชย์ของประเทศไทย เช่นเดียวกับกรณีการกระทำทุรเวชปฏิบัติทางการแพทย์เช่นเดียวกับการแพทย์แบบดั้งเดิมงานวิจัยนี้พบว่าภาระการพิสูจน์ของผู้ที่ได้รับบาดเจ็บภายใต้กรอบของกฎหมายการละเมิดทั่วไป ส่งผลให้ผู้ที่รับบริการการแพทย์ทางไกลมีภาระในการพิสูจน์เช่นว่านี้มากเกินสมควร เมื่อเปรียบเทียบกับระบบกฎหมายไทย ระบบกฎหมายของประเทศเยอรมนีได้สร้างกลไกที่เป็นระบบมาใช้เพื่อช่วยให้ผู้ให้บริการการแพทย์ทางไกลมีความรับผิดชอบต่อการบาดเจ็บนั้นมากขึ้นและคุ้มครองฝ่ายผู้รับบริการได้มากขึ้นในกรณีทุรเวชปฏิบัติในกิจการการแพทย์ทางไกล โดยงานวิจัยนี้มุ่งเน้นไปที่การเปรียบเทียบแนวปฏิบัติของศาลเกี่ยวกับกรณีทุรเวชปฏิบัติทางการแพทย์ระหว่างประเทศไทยและเยอรมนี และชี้ให้เห็นความแตกต่างและประเด็นที่อาจนำเอามาปรับปรุง แนวทางการปฏิบัติของศาลเยอรมนีเป็นตัวอย่างหนึ่งของแนวทางที่ครอบคลุมและแสดงออกถึงการใช้กลไกทางกฎหมายที่ซับซ้อนเพื่อรับรองความปลอดภัยของผู้ป่วยผู้รับบริการและสร้างความรับผิดชอบให้แก่ผู้ให้บริการเพื่อจัดการกับความท้าทายทางกฎหมายในด้านการแพทย์ทางไกล ประเทศไทยสามารถนำแนวทางปฏิบัติจากกรอบกฎหมายของประเทศเยอรมนีมาปรับใช้เพื่อลดภาระการพิสูจน์สำหรับผู้ป่วยและรับรองความรับผิดของผู้ให้บริการด้านการแพทย์ทางไกล เพื่อส่งเสริมความปลอดภัยของผู้ป่วยผู้รับบริการและการรักษาสิทธิของผู้ป่วยในกรณีที่อาจมีการเรียกร้องค่าเสียหายจากการรักษาพยาบาลของผู้ให้บริการการแพทย์ทางไกลในประเทศไทย และเพื่อรับประกันความปลอดภัยและความเป็นอยู่ที่ดีของผู้ป่วยผู้รับบริการการแพทย์ทางไกลในประเทศไทยมากกว่าปัจจุบัน