Digital Commons Network^™

การศึกษาประสิทธิภาพของยาลีโวฟลอกซาซินเพื่อป้องกันการเกิดไข้ในผู้ป่วยมะเร็งต่อมน้ำเหลืองที่ได้รับเคมีบำบัดสูตรริทูซิแมบ ไซโคฟอสฟามาย วินคริสติน ดอกโซรูบิซิน และ เพร็ดนิโซโลน, มุทิตา สุรกิจบวร

Chulalongkorn University Theses and Dissertations (Chula ETD)

หลักการและเหตุผล: การเกิดไข้ในภาวะเม็ดเลือดขาวต่ำถือเป็นภาวะแทรกซ้อนที่เป็นสาเหตุสำคัญของการเสียชีวิตของผู้ป่วยมะเร็งต่อมน้ำเหลืองชนิดนอนฮอดจ์กินที่ได้รับการรักษาด้วยเคมีบำบัดสูตรริทูซิแมบ ไซโคฟอสฟามาย วินคริสติน ดอกโซรูบิซิน และ เพร็ดนิโซโลน (R-CHOP) โดยประโยชน์ของการให้ยาต้านจุลชีพเพื่อป้องกันภาวะแทรกซ้อนดังกล่าวยังไม่ชัดเจน โดยเฉพาะในผู้ป่วยที่ได้รับ G-CSF ร่วมด้วย จึงยังไม่มีคำแนะนำมาตรฐาน งานวิจัยนี้มีวัตถุประสงค์หลักเพื่อประเมินประสิทธิภาพของยาลีโวฟลอกซาซินในการป้องกันการเกิดไข้ตามหลังการให้เคมีบำบัดสูตร R-CHOP ในผู้ป่วยมะเร็งต่อมน้ำเหลืองชนิดนอนฮอดจ์กิน วิธีการศึกษา: เป็นการศึกษาแบบสุ่มที่มีกลุ่มควบคุม ทำการศึกษาผู้ป่วยโรคมะเร็งต่อมน้ำเหลืองชนิดนอนฮอดจ์กินที่ได้รับเคมีบำบัดสูตร R-CHOP ในโรงพยาบาลจุฬาลงกรณ์ ระหว่าง 1 มกราคม พ.ศ. 2566 - 31 ธันวาคม พ.ศ. 2566 โดยแบ่งกลุ่มการศึกษาเป็น 2 กลุ่ม ให้ยาลีโวฟลอกซาซินขนาด 500 mg หรือยาหลอก รับประทานวันละ 1 ครั้ง เป็นระยะเวลา 7 วัน เริ่มหลังให้เคมีบำบัด 1 วัน ผู้ป่วยทุกรายได้รับ G-CSF โดยประเมินผลการศึกษาหลัก คือการเกิดไข้ ในระยะเวลาทั้งสิ้น 120 วันนับตั้งแต่เริ่มเคมีบำบัด และ ผลการศึกษารอง ได้แก่การเกิดภาวะช็อกจากการติดเชื้อ การเสียชีวิตจากการติดเชื้อ การเสียชีวิตจากทุกสาเหตุ การลดขนาดยาเคมีบำบัด ระยะเวลาการเริ่มเกิดไข้ครั้งแรก และ ผลลัพธ์รวม ผลการศึกษา: ผู้ป่วยที่เข้าร่วมงานวิจัยทั้งหมด 58 คน แบ่งเป็นกลุ่มละ 29 คน อายุเฉลี่ย 61 ปี อัตราการเกิดไข้ร้อยละ 10.3 และ ร้อยละ 37.9 ในกลุ่มที่ได้ยาลีโวฟลอกซาซิน และ ในกลุ่มที่ได้ยาหลอกตามลำดับ (P = 0.014) ยาลีโวฟลอกซาซินลดอัตราการเกิดภาวะไข้ร่วมกับเม็ดเลือดขาวต่ำ (ร้อยละ 3.4 เทียบกับ ร้อยละ 24.1, P = 0.022), การลดขนาดยาเคมีบำบัด (ร้อยละ 0 เทียบกับ ร้อยละ 17, P …

Editorial: Pulsed Electric Field Based Technologies For Oncology Applications, Siqi Guo, Gregor Sersa, Richard Heller

Bioelectrics Publications

No abstract provided.

A Pianist Looks At Gerald Finzi's A Young Man's Exhortation, Op. 14, Mary Ann Wilder

Theses and Dissertations--Music

Gerald Finzi is a twentieth-century British composer. Though he also composed for orchestra and chamber ensembles, he is primarily known as a composer of vocal works, both solo and choral. In this solo vocal works, he favored the poetry of Thomas Hardy; six of his nine song cycles set Hardy’s poetry. One of these, A Young Man’s Exhortation, was Finzi’s second song cycle for voice and piano, but the first to earn notable success. Finzi writes for the piano lyrically and independently, as though the piano were a duetting voice—or in many cases, voices. This paper focuses on a …

In-Vivo Assessment Of A Direct-Fed Microbial On Lactation Performances, Blood Biomarkers, Ruminal Fermentation And Microbial Abundance In Transition To Mid-Lactation Holstein Cows, Marcela Bulnes Lopez

Electronic Theses and Dissertations

The transition period is a crucial stage in the lactation cycle and can lead to significant metabolic changes in cows. The use of nutritional interventions, such as direct-fed microbials, may assist cows during the transition from pregnancy to early lactation, reducing the occurrence of metabolic disorders and improving overall health. The primary goal of this study was to assess the effects of a commercial rumen-derived directfed microbial (DFM) product (Galaxis™ Frontier (GF) Native Microbials Inc., CA, USA) on various factors such as performance, blood biomarkers, rumen fermentation, and bacterial population in dairy cows during the transition period up to 100 …

Cryogenic X-Ray Crystallographic Studies Of Biomacromolecules At Turkish Light Source "Turkish Delight", Necati̇ Atalay, Enver Kami̇l Akcan, Mehmet Gül, Esra Ayan, Ebru Destan, Fatma Betül Ertem Kuzucu, Nuretti̇n Tokay, Bariş Çakilkaya, Zeli̇ş Nergi̇z, Gözde Karakadioğlu Usta, Abdullah Kepceoğlu, İlki̇n Yapici, Bi̇lge Tosun, Ni̇lüfer Baldir, Günseli̇ Yildirim, J Austin Johnson, Ömür Güven, Alaleh Shafiei, Nazli Eylül Arslan, Merve Yilmaz, Cahi̇ne Kulakman, Seyi̇de Seda Paydos, Seynep Sena Çi̇nal, Kardelen Şabanoğlu, Ayşegül Pazarçevi̇ren, Ayşenur Yilmaz, Başak Canbay, Bengi̇su Aşçi, Esra Kartal, Serra Tavli, Mehmet Çaliseki̇, Günce Göç, Ari̇f Mermer, Gamze Yeşi̇lay, Sevde Altuntaş, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita, Şaban Teki̇n, Hali̇li̇brahi̇m Çi̇ftçi̇, Serdar Durdaği, Gi̇zem Di̇nler Doğanay, Ezgi̇ Karaca, Burcu Kaplan Türköz, Burak Veli̇ Kabasakal, Ahmet Kati, Hasan Demi̇rci̇

Turkish Journal of Biology

X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g., proteins, nucleic acids, protein complexes, protein-nucleic acid complexes, or large biological compartments). Since its inception, single-crystal cryocrystallography has never been performed in Türkiye due to the lack of a single-crystal X-ray diffractometer. The X-ray diffraction facility recently established at the University of Health Sciences, İstanbul, Türkiye will enable Turkish and international researchers to easily perform high-resolution structural analysis of biomacromolecules from single crystals. Here, we describe the technical and …

The Prison Reentry Experience Of Justice-Involved Veterans, Latta Roosevelt Thomas Jr.

Walden Dissertations and Doctoral Studies

Prison reentry programs attempt to equip justice-involved veterans with life skills necessary for their transition out of prison. This qualitative study addressed the scant understanding of the impact pre-released prison reentry programs have on justice-involved veterans’ transition and reintegration back to the community. The purpose of this qualitative study was to describe the perceptions of justice-involved veterans regarding prison reentry programs that have impacted their transition out of prison. The well-being development model and Castro’s military-to-civilian transition model provided the conceptual framework for this qualitative study, using semistructured questions to interview 11 justice-involved veterans regarding their participation in prison reentry …

Religious Parents’ Awareness Of And Attitudes Toward Their Adolescent Children's Utilization Of Sexual Health Services, Ashley Thompson

Walden Dissertations and Doctoral Studies

Parents are a key influence on their adolescent children's sexual health care decisions. Few researchers have considered the impact of religious environments and parental expectations on adolescents’ use of sexual health services, and research on religious parents’ awareness of adolescents’ use of sexual health services in Christian environments is scarce. The purpose of this basic qualitative study was to explore religious parents' awareness of and attitudes toward their adolescents’ use of sexual health services. The social ecological theory provided the conceptual lens for this study. Eight Christian parents participated in in-depth virtual interviews to discuss their encouragement or discouragement of …

Exploration Of Early Career Teachers’ Perspectives On Preservice Training, Classroom Experiences, And Retention, Ashley Smalley

Theses and Dissertations

To promote the advancement of teacher recruitment, retention, and reduce attrition, K-12 teachers need to be fully prepared for the complex nature of being in a classroom, a classroom filled with students of all types. There is a unique nature to education and one must recognize the complexity of each individual student. The context of this study explores early career teachers’ perspectives on their preparedness for teaching. This research examines teachers’ perspectives in their first to fifth years of teaching who graduated from a North Dakota college. Each participant answered 13 questions regarding their perspectives on the preparation they received …

Comparison Of The Effects Of Telehealth Versus N95 On Nurse-Patient Communication, Tony Christopher Bloomfield

Walden Dissertations and Doctoral Studies

Telehealth and face masks are some of the infection control measures nurses use while attending to patients. Nurses provide the most patient care in hospital settings and thus spend the most time with patients in their recovery journey. Because communication is paramount to the role nurses play as health care professionals, there is a substantial need to investigate how infection control measures affect the quality of nurse-patient communication. The purpose of this quantitative cross-sectional study was to describe the relationship of methods aimed at maintaining social distancing between nurses and patients to nurse-patient communication and to compare differences in the …

Influences On Influenza Vaccine Uptake Among Older Lebanese Adults, Doha D'Agostini

Walden Dissertations and Doctoral Studies

Influenza is a viral infection that is globally transmitted and that increases the risk for infectious diseases, hospitalization, and morbidity and mortality, especially among the older adult population. Although influenza vaccines are recommended in several countries, influenza vaccine hesitancy remains a challenge. In Lebanon, there is minimal research related to older adults’ attitudes and perceptions associated with influenza vaccination. To explore older Lebanese adults’ vaccination experiences and perceptions of the factors that affect their influenza vaccine uptake, a qualitative investigation was conducted. The theory of planned behaviors served as the theoretical framework for the study. A thematic analysis was conducted …

Clinical Vaccination Education Guideline For The African American Community, Margaret Chinedum Nwoji

Walden Dissertations and Doctoral Studies

AbstractVaccination hesitancy is high among African Americans and other people of color. The practice gap addressed in this project was the lack of a culturally sensitive clinical guideline for vaccination education relevant to the African American community. The practice-focused question was answered by developing an evidence-based Clinical Vaccination Education Guideline for the African American Community (CVEGAAC) that was validated by a group of four content experts using the Appraisal of Guidelines, Research, and Evaluation tool. The content experts scored each of the domains above 90%, implying that the CVEGAAC is of high quality and ready for implementation. The end users …

Experiences Of Older Adults With Hiv/Aids Enrolled In Case Management Programs In Northwest Indiana, Antoinette Cardenas

Walden Dissertations and Doctoral Studies

AbstractIn 2016, more than half of those infected with HIV/AIDS were age 50 years or older. Since the introduction of antiretroviral therapy, the survival rate of HIV patients has been on the rise with a predicted increase by 2030, but this has also contributed to early onset of comorbidities such as cardiovascular disease, osteoporosis, and kidney failure. The purpose of this generic qualitative study, driven by ecological systems theory, was to explore the experiences of older adults (age 50 and older) with HIV/AIDS who were enrolled in case management programs in Northwest Indiana. Data were collected from semi structured interviews …

Project Echo Annual Report 2023, University Of New Mexico, Health Sciences Center, Project Echo Communications Team

Project ECHO Annual Reports

No abstract provided.

Effects Of Duckweed On Mosquito Oviposition And Larval Survivorship, Alyssa Gushka

Capstone Showcase

Invasive species are those non-natives to habitat and that negatively impact the environment or human health problems. Invasive mosquitoes threaten the environment and humans, as they transmit 17% of infectious diseases including malaria, West Nile virus and yellow fever. Aedes japonicas and Aedes albopictus are invasive mosquitoes that often deposit eggs in artificial containers. Chemical pesticides, such as Bacillus thuringiensis israelensis (BTI), utilizes endospores to release toxins into the larvae. However, BTI creates negative consequences for the environment and other species. Many plants are being examined to see if they can act as natural pesticides. Duckweeds are native to North …

Vitamin D Enhanced Vitamin D Receptor (Vdr) Inhibition Of Nlrp3 Inflammasome Activation Can Attenuate The Development Of Autoimmune Thyroiditis, Alexzon Mandac

Capstone Showcase

Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disease affecting approximately 2% of the population. Characterized by the gradual loss of thyroid function through an autoimmune attack on the thyroid gland, the disease manifests symptoms that negatively affect one’s quality of life. The mechanisms behind the disease’s pathophysiology are not fully understood; however, researchers are examining the involvement of the NLRP3 inflammasome in the disease. This thesis will address the question of whether Vitamin D can act as an inhibitor of the NLRP3 inflammasome and attenuate the progression of AIT in mouse model. Current investigations explore the effects of NLRP3 inhibition …

War On Covid: Warfare And Its Discontents, Catherine Powell

Faculty Scholarship

This essay analyzes the wartime framing of “fighting” a war on COVID-19—to “fight that invisible enemy,” coronavirus. How might lawmakers address social crises, such as COVID, with the urgency of an emergency without reinforcing our overly-militarized, securitized, and policed state? The problem with a securitized approach is that the notion of security combines conceptual ambiguity with heightened urgency and this indeterminacy can shape and even distort legality in exceptional moments.

I examine the use of the security framework in the context of war-related legal authority to address the pandemic and steps necessary for building a post-pandemic recovery. Importantly, this project …

Utilizing Amr Surveillance Data To Analyze Trends In Escherichia Coli Antibiotic Resistance Levels In The South African Provinces Of Gauteng And The Eastern Cape, Celia Maris

Scripps Senior Theses

Antimicrobial resistant bacterial pathogens pose an ongoing threat to universal public health by causing more severe manifestations of infectious diseases, leading to an increase in healthcare expenditures and higher global mortality rates. Therefore, developing strategies to combat bacterial antimicrobial resistance (AMR) is vital for the future of human health. One promising strategy is through the utilization of AMR surveillance programs. This study focused on using AMR surveillance data from South Africa to analyze changes in Escherichia coli resistance levels to numerous antibiotics between January 2012 and December 2022 in Gauteng Province and the Eastern Cape Province. The study aimed to …

Geographic And Environmental Patterns In Infection By Oyster Macroparasites Along The Georgia Coast, Sofia Markiewicz

Scripps Senior Theses

The eastern oyster (Crassostrea virginica) is a keystone species that stabilizes sediments, cycles nutrients, filters water, and provides habitats and food for estuarine fauna. Oysters are prone to several macroparasites, including oyster pea crabs (Zaops ostreum), mud blister worms (Polydora websteri), and boring sponges (Cliona sp.). Prior research has shown that shellfish infected with blister worms and boring sponges exhibit weaker shells, are more vulnerable to damage and predation, and potentially experience reduced condition. Pea crabs may cause reduced condition, growth, and fertility in their hosts. However, the extent to which these parasites harm their hosts is still unclear. We …

Intra-Latin American Brain Drain Patterns: Speech, Political Action, Statistics, And Testimonies Of Labor Market Insertion Of The Venezuelan Population In Argentina, Pablo Biderbos, Guillermo Boscán Carrasquero, Raquel López Garrido, María Elisa Núñez Brina

Journal of Latino/Latin American Studies (JOLLAS)

Brain drain is known as the phenomenon in which people with knowledge or technical skills migrate to another country. Nowadays, brain drain is one of the most common forms of migration. Latin American countries are not exempt from this type of migration. Thus, in this article, we will investigate this phenomenon through the study and collection of data on Venezuelan people who migrate to Argentina, identifying the trends, characteristics, and situations in which the brain drain takes place.

Research News, Publications, 2023, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2023

Research News, Publications, 2023, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 1 through September 30, 2023

The Role Of Health Crises In Managing The Workflow In Emergency Departments' Cases Study Egyptian Hospitals, Alshaimaa Hussein Mohammed

Mansoura Engineering Journal

Hospitals and emergency departments have faced numerous challenges as they are considered the first line of defence when receiving patients. It also serves as the first detector of epidemiological conditions to which men turn when medical situations appear. In this regard, there are no Egyptian studies available for evaluating the emergency department. The research discussed the new requirements in workflow that necessitate an assessment of the status quo of emergency departments, especially in Egyptian hospital design. The study examined several emergency departments in Egypt. In this regard, the study discusses various methods and precautions taken in hospitals during epidemics, and …

Genotoxic Effects Of Oxyclozanide On Hemocytes Of Galleria Mellonella (Lepidoptera: Pyralidae) Larvae, Ci̇hat Çeli̇k, David Stanley, Ender Büyükgüzel

Turkish Journal of Zoology

Oxyclozanide is a salicylanilide derivative anthelmintic drug with a well-known effect on parasites that cause infections in humans and animals. In this study, the effect of oxyclozanide on DNA damage in hemocytes of Galleria mellonella (L.) (Lepidoptera: Pyralidae) larvae, which has been used as a model organism in many fields, was investigated. Hemolymph was collected from the last instar larvae (7th instar) reared on artificial diets containing oxyclozanide at different concentrations (0.003%, 0.03%, 0.3%, and 1.5%) under laboratory conditions and then hemocytes suspension was prepared. Genotoxic damage in hemocytes was determined by the comet assay which enables microscopically detecting DNA …

Insights From The Environment: Unveiling Methodological Biases And The Impacts Of Beavermediated Environmental Variation On Amphibian-Parasite Dynamics, Leah Marie Fischer

Graduate Student Theses, Dissertations, & Professional Papers

Environmental variation plays an important role in shaping patterns of parasite and pathogen infections within ecosystems and populations. Effective management of wildlife diseases hinges on the detection of parasites and pathogens, followed by the identification of trends in infections that can be used for predicting their spread and implementing control measures. Beavers are ecosystem engineers and keystone species that serve as important sources of environmental variation. In North America, beavers are promoted for the conservation of imperiled taxa like amphibians which are facing declines driven by habitat loss, parasites, and pathogens. Beavers create diverse habitats that attract amphibians, but these …

Analysis Of Covid-19 In Rural America, Ian Gabriel Derickson

Graduate Student Theses, Dissertations, & Professional Papers

The outbreak of the novel coronavirus (SARS-CoV-2) in Wuhan, China and subsequent global pandemic illustrated the need of accurate forecasting and a greater understanding of the underlying dynamics of infectious diseases.

In this dissertation, we examine the six most populous towns in the State of Montana through the lens of the classic SIR model. With this, we show that the six towns in question exhibit similar disease dynamics and population behavior within each wave. Furthermore, we conduct analysis on the age demographics of COVID-19 cases and deaths. This analysis corroborates the findings of the SIR model fits, in that the …

Distinct Patterns Of Auto-Reactive Antibodies Associated With Organ-Specific Immune-Related Adverse Events, Mehmet Altan, Quan-Zhen Li, Qi Wang, Natalie I Vokes, Ajay Sheshadri, Jianjun Gao, Chengsong Zhu, Hai T Tran, Saumil Gandhi, Mara B Antonoff, Stephen Swisher, Jing Wang, Lauren A Byers, Noha Abdel-Wahab, Maria C Franco-Vega, Yinghong Wang, J Jack Lee, Jianjun Zhang, John V Heymach

Faculty, Staff and Student Publications

UNLABELLED: The roles of preexisting auto-reactive antibodies in immune-related adverse events (irAEs) associated with immune checkpoint inhibitor therapy are not well defined. Here, we analyzed plasma samples longitudinally collected at predefined time points and at the time of irAEs from 58 patients with immunotherapy naïve metastatic non-small cell lung cancer treated on clinical protocol with ipilimumab and nivolumab. We used a proteomic microarray system capable of assaying antibody reactivity for IgG and IgM fractions against 120 antigens for systemically evaluating the correlations between auto-reactive antibodies and certain organ-specific irAEs. We found that distinct patterns of auto-reactive antibodies at baseline were …

Extreme Temperatures And Sickness Absence In The Mediterranean Province Of Barcelona: An Occupational Health Issue, Mireia Utzet, Amaya Ayala-Garcia, Fernando G Benavides, Xavier Basagaña

Faculty, Staff and Student Publications

OBJECTIVES: This study aims to assess the association between daily temperature and sickness absence episodes in the Mediterranean province of Barcelona between 2012 and 2015, according to sociodemographic and occupational characteristics.

METHODS: Ecological study of a sample of salaried workers affiliated to the Spanish social security, resident in Barcelona province between 2012 and 2015. The association between daily mean temperature and risk of new sickness absence episodes was estimated with distributed lag non-linear models. The lag effect up to 1 week was considered. Analyses were repeated separately by sex, age groups, occupational category, economic sector and medical diagnosis groups of …

Survey Of West Nile And Banzi Viruses In Mosquitoes, South Africa, 2011-2018, Caitlin Macintyre, Milehna Mara Guarido, Megan Amy Riddin, Todd Johnson, Leo Braack, Maarten Schrama, Erin Gorsich, Antonio Paulo Gouveia Almeida, Marietjie Venter

Faculty, Staff and Student Publications

We collected >40,000 mosquitoes from 5 provinces in South Africa during 2011-2018 and screened for zoonotic flaviviruses. We detected West Nile virus in mosquitoes from conservation and periurban sites and potential new mosquito vectors; Banzi virus was rare. Our results suggest flavivirus transmission risks are increasing in South Africa.

Trem-1, Trem-2 And Their Association With Disease Severity In Patients With Covid-19, Ruyue Fan, Zuowang Cheng, Zhisheng Huang, Ying Yang, Na Sun, Bin Hu, Peibin Hou, Bo Liu, Chuanjun Huang, Shuai Liu

Faculty, Staff and Student Publications

BACKGROUND: Delayed diagnosis and inadequate treatment caused by limited biomarkers are associated with the outcomes of COVID-19 patients. It is necessary to identify other promising biomarkers and candidate targets for defining dysregulated inflammatory states.

METHODS: The triggering receptors expressed on myeloid cell (TREM)-1 and TREM-2 expression from hospitalized COVID-19 patients were characterized using ELISA and flow cytometry, respectively. Their correlation with disease severity and contrast with the main clinical indicators were evaluated.

RESULTS: Increased expression of soluble TREM-1 and TREM-2 in the plasma of COVID-19 patients was found compared to the control group. Moreover, membrane-bound TREM-1 and TREM-2 expression was …

Using Rna-Based Therapies To Target The Kidney In Cardiovascular Disease, Trecia C Palmer, Robert W Hunter

Faculty, Staff and Student Publications

RNA-based therapies are currently used for immunisation against infections and to treat metabolic diseases. They can modulate gene expression in immune cells and hepatocytes, but their use in other cell types has been limited by an inability to selectively target specific tissues. Potential solutions to this targeting problem involve packaging therapeutic RNA molecules into delivery vehicles that are preferentially delivered to cells of interest. In this review, we consider why the kidney is a desirable target for RNA-based therapies in cardiovascular disease and discuss how such therapy could be delivered. Because the kidney plays a central role in maintaining cardiovascular …