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Intersectoral Responses To Climate Change And Waterborne Diseases In The Caribbean Region: Current Actions And Pathways Forward Using The One Health Framework, Sydney A. Steel

Public Health Theses

The Caribbean exists on the frontlines of climate change, and many climate-related threats are already felt throughout the region and projected to worsen in the coming decades. A critical climate-related threat is that of waterborne diseases, as extreme weather events, sea level rise, and temperature increases are shown to contribute to potable water inaccessibility and a more favorable environment for pathogen proliferation and transmission. The complexity of this challenge calls for increased regional and inter-sectoral collaboration in both preparedness and response efforts. Countries and territories across the Caribbean are currently displaying variable yet marked interest in One Health, yet there …

Hsc-Derived Fatty Acid Oxidation In Steady-State And Stressed Hematopoiesis., Jayna J Mistry, Kristian Bowles, Stuart A Rushworth

Faculty Research 2023

Metabolism impacts all cellular functions and plays a fundamental role in physiology. Metabolic regulation of hematopoiesis is dynamically regulated under steady-state and stress conditions. It is clear that hematopoietic stem cells (HSCs) impose different energy demands and flexibility during maintenance compared with stressed conditions. However, the cellular and molecular mechanisms underlying metabolic regulation in HSCs remain poorly understood. In this review, we focus on defining the role of fatty acid oxidation (FAO) in HSCs. We first review the existing literature describing FAO in HSCs under steady-state hematopoiesis. Next, we describe the models used to examine HSCs under stress conditions, and, …

National-Local Dissonance And Exacerbated Vulnerabilities: Covid-19 And Ph Governmental Response, Maria Elissa J. Lao, Pilar Preciousa P. Berse

Political Science Department Faculty Publications

The chasm between good and bad governance widens during times of prolonged crisis. The COVID-19 pandemic proved how well-governed countries could climb out of the initial waves of infection while others struggled or failed to provide substantial efforts to curb the disease. Vulnerable groups such as women, youth, children, the elderly, poor households, as well as communities that depend on the informal economy, with limited access to social and health services, are made even more vulnerable because of the uncertainties brought by the pandemic. Even non-traditional vulnerable groups such as migrant workers and locally stranded individuals have become vulnerable due …

Restricting Scientific Legitimacy In The Age Of Biotechnology?, George P. Smith Ii

Scholarly Articles

In the Age of Biotechnology, there is no more pressing question than whether a philosophy of science exists and translates into a notion that—with or without qualification—the sovereignty of science is central to the advancement of society and should be totally emancipated from concurrence or oversight by society at large. Far too many Americans choose neither to be “informed” nor to accept the responsibilities of citizenship to participate fully in a deliberative democracy—they have chosen instead to exercise their “right” to remain ignorant. Consequently, science reigns without restraint or even review. The scientific community has a coordinated responsibility to society, …

Better Science, Fewer Animals: Catalyzing Nih Grant Making To Improve Biomedical Research And Meet Societal Goals, Mikalah Singer, Paul Locke

Animal Law Review

Animal models are currently the “gold standard” in biomedical research. However, new approaches that do not involve the use of nonhuman animals are evolving to address the public health and medical challenges for which animal models are less well suited. These alternatives represent important advancements and are being recognized as significant advances. There is a clear societal need to encourage such efforts, and there is widespread support to move away from animal-based research by the American public. The National Institutes of Health (NIH) funds the majority of biomedical research in the United States and should be a key player in …

Potential Mechanism Of 5-Ala Treatment Against Feline Infectious Peritonitis Virus Infection By Downstream Metabolite Ppix, Carissa V. Napier

Scripps Senior Theses

Feline coronavirus (FCoV) infection is ubiquitous in domestic cats, and up to 12% of FCoV-infected cats may succumb to Feline Infectious Peritonitis (FIP). FIP is a highly lethal infectious disease caused by FIP virus (FIPV), the virulent biotype of FCoV. It is difficult to properly diagnose FIP, and to this date, there is no effective FCoV vaccine nor licensed therapeutic for FIPV. Considering the threat FIP poses to feline health, there is a demand from both owners and veterinarians for a proper therapeutic to effectively treat the infection. 5-aminolevulinic acid (5-ALA) is a highly bioavailable amino acid that is naturally …

Case Series; Imaging In Lesser-Known Ailments Of The Pituitary Gland And Sellar Region, Harisha H L, Kavya Bhadrapura Thimmegowda, Ajay Hanumanthu, Vikram Patil Dr, Gurumurthy B, Dr Abhijith Roys

Digital Journal of Clinical Medicine

No abstract provided.

Effect Of State Covid-19 Policies On Post-Pandemic Employment, Jason Lawless

Senior Honors Theses and Projects

The COVID-19 pandemic and its subsequent shutdowns pushed many out of their jobs. In the US, there was a wide variety of economic and health system support provided by the states. Using data from Oxford University’s COVID-19 Government Response Tracker, this study attempts to find a relationship between the amount of financial support received by workers and current employment, hypothesizing that states that provided greater income and debt relief are now seeing less employment. This paper uses two different dependent variables, total employment, and restaurant employment. While controlling for population demographics and political leanings, we find that the effect of …

A Case Of Hemophagocytic Lymphohistiocytosis(Hlh) Secondary To Cytomegalovirus Infection In An Immunocompetent Patient, Marcarthur Limpiado, Simerun Singh, Ajay Iyer, William Zvagelsky, Shruti Verma, Minar Rane, Emadeldeen Elgwairi

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Subacute Combined Degeneration In Atypical Case, Ryan Molina

Gulf Coast Division GME Research Day 2023

No abstract provided.

Disseminated Peritoneal Coccidioidomycosis, Ryan Meyer, Tamir Bresler

Far West Division GME Research Day 2023

No abstract provided.

‘I’M Not A Virus’: Asian Hate In Donald Trump’S Rhetoric, Jennifer Zheng, Joseph Zompetti

Faculty Publications - Communications

Since the start of Covid-19, anti-Asian sentiment spiked. From March 2020 to June 2021, there were a total of 9,081 self-reported incidents of hate across the United States (Stop AAPI Hate. (2021). As Covid-19 spread into the U.S., President Trump immediately blamed China by referring to the virus as the ‘Chinese Virus’ and used the hashtag #ChineseVirus on Twitter (Weise, E. 2021). Anti-Asian hashtags soared after Donald Trump first tied COVID-19 to China on Twitter. (USA Today. https://www. usatoday.com). Anti-Asian rhetoric expressed on Twitter grew after Trump’s tweet about the ‘Chinese virus,’ and the number of Chinese and other Asian …

Relative Adrenal Insufficiency Is A Risk Factor And Endotype Of Sepsis - A Proof-Of- Concept Study To Support A Precision Medicine Approach To Guide Glucocorticoid Therapy For Sepsis, Chia-Hua Wu, Ling Guo, Dan Hao, Qian Wang, Xiang Ye, Misa Ito, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang-An Li

Saha Cardiovascular Research Center Faculty Publications

Introduction: 25-60% of septic patients experience relative adrenal insufficiency (RAI) and glucocorticoid (GC) is frequently used in septic patients. However, the efficacy of GC therapy and whether GC therapy should be based on the status of RAI are highly controversial. Our poor understanding about the pathogenesis of RAI and a lack of RAI animal model present significant barriers to address these critical issues.

Methods: Scavenger receptor BI (SR-BI) regulates stress-induced GC (iGC) production in response to stress. We generated SF1CreSR-BIfl/fl mice and utilized the mice as a RAI model to elucidate the pathogenesis of RAI and GC therapy in sepsis. …

Effects Of Chlorhexidine Bathing In Addition To Soap And Water Baths On Infection Rates In Plano Picu And Acs, Anabel Olivia, Cameron Miller, Emily Haig, Marilyn Medrano-Lopez

2022

No abstract provided.

Stars, Stripes, And Surveillance: The United States' Failure To Regulate Data Privacy, Sam Begland

American University International Law Review

In the wake of the United States Supreme Court's devastating decision to strip Americans of their constitutional right to abortion in Dobbs v. Jackson Women’s Health Organization, data privacy is more salient than ever. Without adequate data regulations, state governments and anti-abortion activists alike can harass and prosecute pregnant people attempting to exercise their bodily autonomy. This comment argues that the United States has violated its obligations under the International Covenant on Civil and Political Rights (ICCPR) Article 17 by failing to protect against interference with the use and collection of reproductive health data. Further, this comment analyzes interpretations of …

Creating Change In Pediatric Health Disparities: Utilizing Systemsbased Thinking To Overcome Disparities Affecting Pediatric Type 1 Diabetes In Kentucky, Sydney Speed

Lewis Honors College Thesis Collection

Healthcare disparities are perpetuated and upheld for patients with type 1 diabetes (T1D) in rural and underserved urban areas of Kentucky. By adopting systems-based thinking, we can identify areas of the healthcare system to change to eliminate these disparities. Namely, key leverage points of this system include distribution and utilization of resources, finances and the movement of money, and communication pathways. To address the disparities surrounding pediatric T1D in Kentucky, a state-wide medical event called Kentucky Diabetes Family Day (KDFD) was hosted. The focus of this event was to lessen the effects of these specific healthcare disparities by altering key …

Before They Could Be Saved: Aids Voices Before Protease Inhibitors, Julian J. Willis

Honors Undergraduate Theses

The intent of this thesis is to explore writing during the start of the AIDS epidemic in the U.S. States. This time period encompasses the early 1980s to mid-1990s before Protease Inhibitors were FDA approved which was the medical breakthrough drug that helped turn an HIV diagnosis from a death sentence to a chronic condition. This thesis will be an examination of three themes: “Gay White Cis Male Experience of HIV/AIDS”,” Marginalized Identity Experience of HIV/AIDS” and an exploration of two plays written during the height of the AIDS epidemic that were later turned into HBO productions: The Normal Heart …

Liminality & Festivities Facilitating Pandemic Fatigue : Songkran And The Third Wave Of Covid-19 Outbreak In Thailand, Steve Kwok-Leung Chan

Journal of Urban Culture Research

Asian countries were outstanding performers in preventing COVID-19 initially, but many suffered from a new wave of the outbreak in mid-2020. These countries sealed off their borders from the possible spread of the virus from outside. For more than one year, social distancing restrictions were applied and successfully kept the infection rates at a low level. Drawing on the initial findings of Chang et al. (2020) on the spread of the infectious disease intracity and intercity during festivals, this paper examines the outbreaks, with a probe into the case of Songkran, or the Water Festival of Thailand. The author found …

Exploring The Mechanisms By Which Camel Lactoferrin Can Kill Salmonella Enterica Serovar Typhimurium And Shigella Sonnei, Hussein A. Almehdar, Nawal Abd El-Baky, Ehab H. Mattar, Raed S. Albiheyri, Atif Bamagoos, Abdullah A. Aljaddawi, Vladimir N. Uversky, Elrashdy M. Redwan

Molecular Medicine Faculty Publications

There is a continuously increasing pressure associated with the appearance of Salmonella enterica Serovar typhimurium (S. typhimurium) and Shigella sonnei (S. sonnei) that have developed pathogenic multiple antibiotic resistance and the cost of cure and control of these enterobacteriaceae infections increases annually. The current report for first time demonstrated the distinguished antimicrobial action of camel lactoferrin (cLf) obtained from the milk of different clans of camel in Saudi Arabia against S. typhimurium and S. sonnei. These cLf subtypes showed comparable antimicrobial potential when tested against the two bacterial strains but were superior to either bovine (bLf) …

Limosilactobacillus Fermentum 3872 That Produces Class Iii Bacteriocin Forms Co-Aggregates With The Antibiotic-Resistant Staphylococcus Aureus Strains And Induces Their Lethal Damage, Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Irina O. Chikileva, Tatiana N. Abashina, Alexander N. Panin, Vyacheslav G. Melnikov, Natalia E. Suzina, Ilya N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev

Molecular Medicine Faculty Publications

LF3872 was isolated from the milk of a healthy lactating and breastfeeding woman. Earlier, the genome of LF3872 was sequenced, and a gene encoding unique bacteriocin was discovered. We have shown here that the LF3872 strain produces a novel thermolabile class III bacteriolysin (BLF3872), exhibiting antimicrobial activity against antibiotic-resistant Staphylococcus aureus strains. Sequence analysis revealed the two-domain structural (lysozyme-like domain and peptidase M23 domain) organization of BLF3872. At least 25% residues of this protein are expected to be intrinsically disordered. Furthermore, BLF3872 is predicted to have a very high liquid-liquid phase separation. According to the electron microscopy data, the bacterial …

Figure Set Update: An Inquiry-Based Module Aligned With The 4dee Framework For Teaching About Functional Responses And Biological Control, Rosny Jean, Linda Auker, Suann Yang, Jeremy Hsu

Open Educational Resources

THE ISSUE

Biological control agents are used in a wide range of contexts to limit damage from pests. However, the broader ecological consequences of such agents often are unclear before ecological risk assessments are performed. This Figure Set guides students to think through potential consequences of using biological control agents, and then uses a specific study to challenge students to interpret results from laboratory and caged field experiments. This Figure Set also introduces the concept of functional responses to students.

FOUR DIMENSIONAL ECOLOGY EDUCATION (4DEE) FRAMEWORK

• Core Ecological Concepts:
• Organisms
• Resources and regulators
• Communities
• Predation
• Ecology Practices:
• Quantitative reasoning and …

The Relationship Between Ventilation Rates In Schools And The Indoor Airborne Transmission Potential Of Covid-19, Seamus Harrington, Mark Mulville, Spyros Stravoravdis

Articles

The requirement for natural ventilation strategies in classrooms to perform in respect to both their inherent and adaptive capacity is necessary to mitigate the risk of transmission associated with infectious airborne pathogens such as COVID-19. This paper assesses the performance of ten classrooms considering (a) the designed versus actual ventilation capacity; (b) the probability of airborne disease transmission by unit time resulting from calculated ventilation rates and (c) the reduction of transmission risk associated with mask wearing by all occupants.

Monitored air changes per hour (ACH) range from 0.26–1.7, demonstrating that none of the classrooms meet designed ventilation rate whilst …

Impact Of Covid-19 Nationwide Lockdowns And Unlock Phases In India On River Water Quality Of Upper Part Of The Ganga River, Dhara Kakwani, Abha Kumari, Kumar Suranjit Prasad, Bablu Prasad

Applied Environmental Research

The river water quality index (RWQI) of the upper Ganga canal has been computed to assess the effect of lockdown and unlock phases lead down by COVID-19 in India. Geospatial distribution of RWQI from January 2019 to December 2021 in the study area revealed significant impacts of lockdown on water quality. However, unlock phases (post lockdown) have deteriorated water quality since August 2020 and reached to actual conditions of the river by August 2021. To evaluate the lockdown as a management strategy to clean the river, other factors were reviewed including rainfall data, migration, and other activities. The results revealed …

Vibrio Bacteria Surveillance Post-Hurricanes Ian And Nicole: How Climate Change Affects Pathogens, Lillian Walker

Theses & ETDs

Vibrio is a genus of Gram-negative bacteria typically found in warm, brackish water. Some Vibrio species can infect humans, such as Vibrio vulnificus, also known as flesh-eating bacteria, which infects roughly 50 to 100 people and kills 16 of them annually in the United States, mostly in Gulf Coast states such as Florida[1], [2]. In fact, Florida alone had 74 cases and 17 deaths in 2022, an increase from 34 cases and 10 deaths in 2021[3]. This increase is thought to be correlated with the Category 4 storm Hurricane Ian that made landfall in Cayo Costa in late September of …

Just Tell Me: A Robot-Assisted E-Health Solution For People With Lower-Extremity Disability, Alexander Coutras, Omar Obidat, Michelle Zhu, Weitian Wang

School of Computing Faculty Scholarship and Creative Works

Robotics technology has been increasingly applied to healthcare contexts to enhance efficiency and safety in healthcare processes in recent years. People with mobility impairments and disabilities often require caretakers in their lives. Fortunately, robots can provide attention and assistance consistently for them instead of human caretakers. Motivated by this, we develop a robot-assisted e-health solution to empower the patients' daily lives and improve their wellbeing in this study. A transfer learning-based approach is proposed to train the robot to understand and identify patients' needs through a small dataset. Using the proposed approach, the robot is able to understand the patient's …

The Search For Something Better: Narrative Inquiry Into Why Women In Non-Faculty Roles Left Higher Education During Covid-19 Pandemic, Amanda Corsi

West Chester University Doctoral Projects

Stressors brought on by the COVID-19 pandemic for women working in non-faculty roles in higher education still need to be understood. While there is extensive research on voluntary turnover, the influence of the pandemic on how and why women choose to leave the field is still lacking. Most research on higher education professionals fails to include the perspective of women in non-faculty positions. This study conducted a qualitative narrative inquiry to understand the experiences of women in non-faculty roles who worked in higher education during the COVID-19 pandemic and how that influenced their reasons for turnover decision-making. The results found …

The Impact Covid-19 On The Healthcare Industry’S Systems And Policies: A Case Study, Jameyshia Franklin

West Chester University Doctoral Projects

People worldwide experienced some impacts from the 2019 Coronavirus at various degree. The healthcare industry worldwide was significantly affected by the high volume of patients being infected with the Coronavirus. The COVID-19 virus brought on several challenges for the healthcare industry and the federal government in the United States. Hospitals operated under severe circumstances to treat sick COVID-19 patients and keep their employees safe from contracting the disease. Government mandated social distancing, mask wearing, and cancelation and closing of services to assist with stopping the spread of the virus. This study aimed to identify how the pandemic affected the healthcare …

Differential Diagnosis Of Dna Viruses Related To Reproductive Disorder On Sows By Multiplex-Pcr Technique, T N. Nguyen, H T T Le, H L X Vu, P X. Dinh

Department of Animal Science: Faculty Publications

The newly emerged diseases caused by ASFV and PCV3 and their confirmed prevelance in Vietnam whereas most of available common commercial methods such as ELISA or realtime PCR designed for detecting single pathogen per reaction, highlighted a necessity for another diagnostic method to simultaneously detect and differentiate DNA viruses that are related to reproductive failures in sow herds including PCV2, PCV3, PPV, ASFV. In this communication, a diagnostic multiplex-PCR (mPCR) was established with pathogen-specific primers selected from previous studies and another set of primers designed for COX1 gene serving as an internal amplification control (IAC). The predicted products of PCV2, …

Identification Of Rickettsia Prowazekii Methionine Aminopeptidase Inhibitors And Development Of Thermal Shift Assays For Burkholderia Pseudomallei Ispf And Sars-Cov-2 3cl Protease, Ishpriya Sharma

Graduate Research Theses & Dissertations

There is a crucial need for new antibacterial agents to combat the increase in antibiotic resistance. Methionine aminopeptidase (MetAp) is an enzyme that removes the amino-terminal methionine residue from newly synthesized proteins, an important step in the maturation of proteins. As such, MetAp is a target for the development of antibacterial and anticancer agents. One such bacterial target is Rickettsia prowazekii (Rp), the causative agent of epidemic typhus. To discover new inhibitors of RpMetAp1, the MMV Malaria Box, which is a collection of 400 compounds with drug-like and probe-like compounds, was screened using a high throughput fluorescence-based RpMetAp1 enzyme inhibition …

Interspecific Oral Rabies Vaccine Bait Competition In The Southeast United States, Wesley C. Dixon, Jacob E. Hill, Richard Chipman, Amy J. Davis, Amy Gilbert, James C. Beasley, Olin E. Rhodes Jr., Guha Dharmarajan

United States Department of Agriculture Wildlife Services: Staff Publications

The United States Department of Agriculture’s National Rabies Management Program (NRMP) has coordinated the use of oral rabies vaccination (ORV) to control the spread of raccoon rabies virus variant west of the Appalachian Mountains since 1997. Working with state and local partners, the NRMP deploys ORV baits containing a rabies vaccine, primarily targeting raccoon populations (Procyon lotor). Bait competition between raccoons and non-target species may limit the effectiveness of ORV programs, but the extent of bait competition remains poorly quantified, particularly in the southeastern United States. We placed placebo ORV baits in bottomland hardwood (n = 637 baits) and upland …