Digital Commons Network^™

Inherited Human Itk Deficiency Impairs Ifn-Γ Immunity And Underlies Tuberculosis, Masato Ogishi, Rui Yang, Rémy Rodriguez, Dominic P Golec, Emmanuel Martin, Quentin Philippot, Jonathan Bohlen, Simon J Pelham, Andrés Augusto Arias, Taushif Khan, Manar Ata, Fatima Al Ali, Flore Rozenberg, Xiao-Fei Kong, Maya Chrabieh, Candice Laine, Wei-Te Lei, Ji Eun Han, Yoann Seeleuthner, Zenia Kaul, Emmanuelle Jouanguy, Vivien Béziat, Leila Youssefian, Hassan Vahidnezhad, V Koneti Rao, Bénédicte Neven, Claire Fieschi, Davood Mansouri, Mohammad Shahrooei, Sevgi Pekcan, Gulsum Alkan, Melike Emiroğlu, Hüseyin Tokgöz, Jouni Uitto, Fabian Hauck, Jacinta Bustamante, Laurent Abel, Sevgi Keles, Nima Parvaneh, Nico Marr, Pamela L Schwartzberg, Sylvain Latour, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis

Department of Dermatology and Cutaneous Biology Faculty Papers

Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging. They have CD4+ αβ T lymphocytopenia with a concomitant expansion of CD4-CD8- double-negative (DN) αβ and Vδ2- γδ T lymphocytes, both displaying a unique CD38+CD45RA+T-bet+EOMES- phenotype. Itk-deficient mice recapitulated an expansion of the γδ T and DN αβ T lymphocyte populations in the thymus and spleen, respectively. Moreover, the patients' T lymphocytes secrete small amounts of IFN-γ in …

Medical Training Of Seafarers: International Maritime Health Foundation (Imhf) Expert Panel Consensus Statement, Nebojša Nikolić, Jon Magnus Haga, Jens Tülsner, Per Otto Årland, Alf Magne Horneland, Bill Kavanagh, Klaus Seidenstucker, Spike Briggs, Inger Lund-Kordahl, Cecilia Simolin Pernilla

Articles

Background: Medical emergencies and on-going medical conditions on board may seriously impair seafarers’ health and safety, and also negatively impact on future work prospects for seafarers. When a seafarer gets ill or injured on a ship, medical treatment often relies on the competences on his colleagues on board. The aim of this project was to establish a consensus-based minimum standard for medical education for seafarers, in order to ensure competency for adequate management of ill-health on board.

Materials and methods: International Maritime Health Foundation (IMHF) conducted a workshop on medical training of seafarers. A research-based approach to gain consensus on …

Condom Use Self-Efficacy Score And Risky Sexual Behavior Among High School Students In Southern Ethiopia, Gizachew Kebede Bassore, Hadi Danawi, Linda G. Marc, Chinaro Kennedy

Journal of Social, Behavioral, and Health Sciences

There is emerging evidence of a rise in new human immunodeficiency virus (HIV) infections in Ethiopia. This may partly be explained by an increase in risky sexual behaviors among high school adolescents. The current study was conducted to explore the association between a set of predictor variables (comprehensive HIV knowledge and condom use self-efficacy score) and an outcome variable of risky sexual behavior among high school adolescents in the Angacha District of Southern Ethiopia. The study employed a quantitative cross-sectional design to answer the research question. Primary data were collected using a self-administered questionnaire from 374 participants using a stratified …

Community Health Needs Assessment Wood River Valley Region 2023, Mcallister Hall, Lantz Mcginnis-Brown, Aisha Kayed, Taylor Neher, Vanessa Fry

Idaho Policy Institute Reports

This Community Health Needs Assessment (CHNA) aims to identify the health needs of various populations in Blaine County, Idaho through a Social Determinants of Health (SDoH) framework, which defines health in the broadest sense and recognizes numerous factors—from employment to housing to access to health care—that have an impact on the community’s health.

Ratio Of Coefficients Of Variation For Comparing The Dispersions Of Several Independent Populations, Abbas Bahrampour, Zeynab Avazzadeh, Mohamad Reza Mahmoudi

Journal of Statistics Applications & Probability

The coefficient of variation (CV) is an important and useful statistical tool for comparing several populations. In cases where there are multiple populations with different means and variances, the ratio of the coefficients of variation (CVs) is a good way to compare the dispersion of the populations. Because of the possible minor differences between multiple CVs and the lack of a robust interpretation, the ratio of CVs is more accurate than the difference of CVs. When a statistical analysis consists of some simultaneous statistical tests such as equality of several CVs, multiple testing is useful. As an example, the multiple …

Relationship Between The Standard Of Living, Economic Situation, And Security Situation Of Nigerians During The Covid-19 Pandemic. A Non-Parametric Analysis Approach, A. F. Adedotun, O. P. Ogundile, G. O. Odekina, I. V. Okafor

Journal of Statistics Applications & Probability

The Covid-19 pandemic has crippled the economic activities of so many nations across the globe since its outbreak in 2019. This study is focused on the resultant effect of the covid-19 pandemic in terms of standard of living, perception of economic and security situation of Nigerians. This study used a non-parametric approach involving Spearman rank correlation and Mann-Whitney U to analyze primary data acquired from NoiPolls’ online administration of questionnaires during the Covid-19. The result obtained from this study depicts that there is a significant relationship between the security situation and perception of the country’s economic situation. The standard of …

Simple Polystyrene Microfluidic Device For Sensitive And Accurate Sers-Based Detection Of Infection By Malaria Parasites, Maria Joao Oliveira, Soraia Caetano, Ana Dalot, Filipe Sabino, Tomas Calmeiro, Elvira Fortunato, Rodrigo Martins, Eulalia Pereira, Miguel Prudencio, Hugh Byrne, Ricardo Franco, Hugo Aguas

Articles

Early and accurate detection of infection by pathogenic microorganisms, such as Plasmodium, the causative agent of malaria, is critical for clinical diagnosis and ultimately determines the patient’s outcome. We have combined a polystyrene-based microfluidic device with an immunoassay which utilises Surface-Enhanced Raman Spectroscopy (SERS) to detect malaria. The method can be easily translated to a point-of-care testing format and shows excellent sensitivity and specificity, when compared to the gold standard for laboratorial detection of Plasmodium infections. The device can be fabricated in less than 30 min by direct patterning on shrinkable polystyrene sheets of adaptable three-dimensional microfluidic chips. To validate …

Multi-Omic Association Study Identifies Dna Methylation-Mediated Genotype And Smoking Exposure Effects On Lung Function In Children Living In Urban Settings, Matthew Dapas, Emma E. Thompson, William Wentworth-Sheilds, Selene Clay, Cynthia M. Visness, Agustin Calatroni, Joanne E. Sordillo, Diane R. Gold, Robert A. Wood, Melanie Makhija, Gurjit K. Khurana Hershey, Michael G. Sherenian, Rebecca S. Gruchalla, Michelle A. Gill, Andrew H. Liu, Haejin Kim, Meyer Kattan, Leonard B. Bacharier, Deepa Rastogi, Matthew C. Altman, William W. Busse, Patrice M. Becker, Dan Nicolae, George T. O'Connor, James E. Gern, Daniel J. Jackson, Carole Ober

Allergy & Immunology Articles

Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those most relevant to pediatric populations and populations of different ancestries. In this study, we performed genome-wide association analyses of lung function in a multiethnic cohort of children (n = 1,035) living in low-income urban neighborhoods. We identified one novel locus at the TDRD9 gene in chromosome 14q32.33 associated with percent predicted forced expiratory volume in one second (FEV1) (p = 2.4x10-9; βz = -0.31, …

National Health Insurance For The United States, Ashley Herrell

Integrated Studies

Approximately 46 million U.S. citizens lack health insurance despite the nation's abundant resources. The imperative for universal healthcare arises, with a proposed solution being mandatory national health insurance. This paradigm shift, championed by the U.S. House of Representatives, Senate, and citizens, aims to eradicate the issue of people foregoing healthcare due to lack of insurance, promising to enhance collective well-being. The U.S. stands out among high-income countries without comprehensive universal healthcare, leading to disproportionately high out-of-pocket expenses and inferior health outcomes. Social determinants like income, race, and rural residence exacerbate the challenge by limiting healthcare access for vulnerable groups. Embracing …

An Examination Of The Sufficiency Of Emergency Planning In New York City Hospitals For Vulnerable Populations Needing Communication Or Language Assistance, Rosemary Mcdonnell

Theses and Dissertations

Background: While all populations are susceptible to certain hazards that may expose their vulnerabilities in a disaster, populations with no or limited English proficiency, sight limitations, and hearing limitations are especially at risk due to communication and language barriers that they consistently experience. Purpose: This study explored the sufficiency of emergency planning that vulnerable populations with communication barriers may receive in a New York City hospital setting. It investigated the emergency plans, procedures, and practices that hospitals have for these specific, at-risk populations. The sufficiency of these were measured in accordance with their ability to meet the appropriate regulatory standards …

The Effects Of Long-Term Incarceration On Women: An Investigation Of The Re-Entry Journey Of Four Long-Term Incarcerates Living At A Re-Entry Program, Francine White

Theses and Dissertations

The social problem under investigation was that although there had been a general rise in the number of incarcerated women in the United States, these women faced several challenges trying to re-enter society upon their release from incarceration. The purpose of this qualitative single case study research was to explore how a re-entry program, from the perspective of previously incarcerated women, attempted to integrate incarcerated women back into society. The study considered how the re-entry program could be designed to reduce recidivism in women. The research design was a qualitative case study with six data sources: individual interviews of previously …

Posttraumatic Stress Disorder In Registered Nurses During The Covid-19 Pandemic, Jonah A. Bergstrand, Chanda N. Gritters, Saydee Homolka, Mikaela M. Morrison

All Electronic Theses and Dissertations

Posttraumatic stress disorder (PTSD) is a mental health illness that has become an increasing concern during the COVID-19 pandemic. Individuals suffering from PTSD are more likely to suffer from suicidal ideation, suicidal attempts, and death by suicide. Due to the recency of the COVID-19 pandemic, the research conducted on PTSD in nurses from the pandemic is limited. The PTSD checklist for DSM-5 (PCL-5) was distributed to Minnesota Nurses Association (MNA) and Faith Community Nurse Network of the Greater Twin Cities (FCNNTC). Additionally, participants filled out what field of medicine they worked in and their perceived emotional burden from working during …

Early Recognition Of Urgent Medical Needs By Washington County Correctional Officers, Nina Lebrun, Delia C. Paul, Lisa Sullivan, Abby Marie Young

All Electronic Theses and Dissertations

According to Minnesota law, inmates and detainees have a right to physical and mental health care services (Correctional Health and Local Public Health Work Group, 2007). However, a needs assessment completed with Washington County Jail determined that there is a potentially dangerous gap during the intake process wherein detainees who are awaiting formal booking may experience a medical emergency before their full medical history is known (R. Heinen, personal communication, September 29, 2021). Therefore, the research team worked to develop a curriculum for Correctional Officers in order to better prepare them to recognize and respond to medical emergencies in detainees, …

Panarchy Theory For Convergence, Shana M. Sundstrom, David G. Angeler, Jesse Bell, Michael J. Hayes, Jennifer Hodbod, Babak Jalalzadeh‑Fard, Rezaul Mahmood, Elizabeth Vanwormer, Craig R. Allen

School of Natural Resources: Faculty Publications

Coping with surprise and uncertainty resulting from the emergence of undesired and unexpected novelty or the sudden reorganization of systems at multiple spatiotemporal scales requires both a scientific process that can incorporate diverse expertise and viewpoints, and a scientific framework that can account for the structure and dynamics of interacting social-ecological systems (SES) and the inherent uncertainty of what might emerge in the future. We argue that combining a convergence scientific process with a panarchy framework provides a pathway for improving our understanding of, and response to, emergence. Emergent phenomena are often unexpected (e.g., pandemics, regime shifts) and can be …

Connecting Distinct Realms Along Multiple Dimensions: A Meta-Ecosystem Resilience Perspective, David G. Angeler, Jani Heino, Juan Rubio-Ríos, J. Jesús Casas

School of Natural Resources: Faculty Publications

Resilience research is central to confront the sustainability challenges to ecosystems and human societies in a rapidly changing world. Given that social-ecological problems span the entire Earth system, there is a critical need for resilience models that account for the connectivity across intricately linked ecosystems (i.e., freshwater, marine, terrestrial, atmosphere). We present a resilience perspective of meta-ecosystems that are connected through the flow of biota, matter and energy within and across aquatic and terrestrial realms, and the atmosphere. We demonstrate ecological resilience sensu Holling using aquatic-terrestrial linkages and riparian ecosystems more generally. A discussion of applications in riparian ecology and …

1 Parents Experiences In Slovenia During The Covid-19 Pandemic, Petra Klanjsek, Leona Cilar Budler, Jadranka Stricevic, Tara L. Sacco, Barbara Kegl

Nursing Faculty/Staff Publications

Introduction: The COVID-19 pandemic emerged here in March 2020. The pandemic and lockdowns have been the cause of many parents doing both paid and unpaid work at home. Everyday life was a great challenge. Challenges, insecurities, and changes have caused people anxiety and fear, which has been and will only be reflected in the mental well-being of individuals. We wanted to find out how parents faced their fears, worries, and daily lives during the epidemic.

Methods: A cross-sectional study was conducted to gain insight into parents’ experiences during the COVID-19 pandemic in Slovenia. Casual parental sampling was used and a …

Novel Correlation Coefficients For Interval-Valued Fermatean Hesitant Fuzzy Sets With Pattern Recognition Application, İbrahi̇m Demi̇r

Turkish Journal of Mathematics

A combination of interval-valued Fermatean fuzzy sets with Fermatean hesitant fuzzy elements in the form of interval values is known as an interval-valued Fermatean hesitant fuzzy set. Since Fermatean hesitant fuzzy sets are effective instruments for representing more complex, ambiguous, and hazy information, interval-valued Fermatean hesitant fuzzy sets are expansions of these sets. This investigation will concentrate on four different types of correlation coefficients for Fermatean hesitant fuzzy sets and expand them to include correlation coefficients and weighted correlation coefficients for interval-valued Fermatean hesitant fuzzy sets. Finally, the numerical examples demonstrate the viability and usefulness of the suggested methodologies in …

Enhanced Fractional Adaptive Processing Paradigm For Power Signal Estimation, Naveed Ishtiaq Chaudhary, Zeshan Aslam Khan, Muhammad Asif Zahoor Raja, Iqra Ishtiaq Chaudhary

Articles

Fractional calculus tools have been exploited to effectively model variety of engineering, physics and applied sciences problems. The concept of fractional derivative has been incorporated in the optimization process of least mean square (LMS) iterative adaptive method. This study exploits the recently introduced enhanced fractional derivative based LMS (EFDLMS) for parameter estimation of power signal formed by the combination of different sinusoids. The EFDLMS addresses the issue of fractional extreme points and provides faster convergence speed. The performance of EFDLMS is evaluated in detail by taking different levels of noise in the composite sinusoidal signal as well as considering various …

Antibacterial And Antifungal Activity Of Methanolic Extracts Of Salix Alba L. Against Various Disease Causing Pathogens, Bilal Javed, F. Farooq, M. Ibrahim, H.A.B. Abbas, H. Jawwad, S.S. Zehra, H.M. Ahmad, A. Sarwar, K. Malik, K. Nawaz

Articles

The present study was aimed to manifest the antibacterial and antifungal activity of methanolic extracts of Salix alba L. against seven Gram-positive and Gram-negative bacterial pathogens e.g. Streptococcus pyogenes, Staphylococcus aureus (1), S. aureus (2), Shigella sonnei, Escherichia coli (1), E. coli (2) and Neisseria gonorrhoeae and three fungal isolates from the air such as Aspergillus terreus, A. ornatus, and Rhizopus stolonifer. Two different serotypes of S. aureus and E. coli were used. The agar well-diffusion method results showed the dose-dependent response of plant extracts against bacterial and fungal strains while some organisms were found resistant e.g. E. coli (1), …

Research4life (R4l) Scholar Program: New Initiative To Promote Diversity, Equity, And Inclusion In Medicine Through A Bottom-Up Approach, Somaya Albhaisi

Health Sciences Education Symposium

Purpose and background: According to the Pew Research Center, Hispanics are 17% of the workforce but only represent 8% of people in a science, technology, engineering and math (STEM) position. African Americans are 11% of the workforce but hold 9% of STEM jobs. The Research4Life (R4L) program is designed to increase the number of minority students who pursue medical education and careers in Medicine and research. A formalized mentorship and clinical research program is one pipeline to increase representation of underrepresented groups in medicine and academic medical careers.(1)

Description of Innovative Practice: The R4L scholar program is a structured summer …

Implications Of Twitter During Its Use In Public Health Practice Involving The Distribution Of The Covid-19 Vaccine, Mia Casingal

Theses, Dissertations and Capstones

Introduction – There were 4.89 projected billion social media users in 2023. Social media platforms such as Twitter have allowed public health organizations to spread information regarding COVID-19 vaccines to the public. Twitter permits government organizations and public health agencies to release accurate information as a primary level of rapid communication.

Purpose – The purpose of this research was to explore the impact of the social media platform, Twitter, on public health information throughout the COVID-19 pandemic regarding the spread of information involving COVID-19 vaccine distribution to the public.

Methodology – This study utilized a literature review with a semi-structured …

Characterization Of Food Chain Clostridioides Difficile Isolates In Terms Of Ribotype And Antimicrobial Resistance, Pilar Marcos, Aoife Doyle, Paul Whyte, Thomas R. Rogers, Maire Mcelroy, Seamus Fanning, Jesus Maria Frias, Declan Bolton

Articles

The aim of this study was to characterize C. difficile isolates from the farm, abattoir, and retail outlets in Ireland in terms of ribotype and antibiotic resistance (vancomycin, erythromycin, metronidazole, moxifloxacin, clindamycin, and rifampicin) using PCR and E-test methods, respectively. The most common ribotype in all stages of the food chain (including retail foods) was 078 and a variant (RT078/4). Less commonly reported (014/0, 002/1, 049, and 205) and novel (RT530, 547, and 683) ribotypes were also detected, but at lower frequencies. Approximately 72% (26/36 tested) of the isolates tested were resistant to at least one antibiotic, with the majority …

Drawing On The Strengths Of Community Health Workers To Address Sexually Transmitted Infections: Roles, Medicaid Reimbursement, And Partnerships, Naomi Seiler, Katie Horton, Paige Organick-Lee, Claire Heyison, Alexis Osei, Greg Dwyer, Aaron Karacuschansky, Mekhi Washington, Amanda Spott

Health Policy and Management Informal Communications

Rates of bacterial sexually transmitted infections (STIs) in the United States are high and, largely, still soaring. Though chlamydia cases have decreased slightly since 2017, gonorrhea and syphilis have increased by 25% and 68%, respectively, and congenital syphilis has increased by 184%. Bacterial STI can lead to pain, infertility, and even, in the case of syphilis and congenital syphilis, death. With appropriate detection and treatment, all of these STIs are curable. And yet a range of barriers between communities and the healthcare system perpetuate the STI epidemic.

Community health workers (CHWs) could play a key role in helping bridge the …

Sexually Transmitted Infections And Social Determinants Of Health: Emerging Opportunities In The Medicaid Program, Naomi Seiler, Katie Horton, Paige Organick-Lee, Mekhi Washington, Taylor Turner, Lily Ryan

Health Policy and Management Informal Communications

No abstract provided.

Improving Hepatitis C Virus Screening Through Bundle Interventions, Jennifer West

Doctor of Nursing Practice Projects

Abstract

Hepatitis C (HCV) is estimated to impact 57,500 people in the US and is a leading infectious disease worldwide. The purpose of this DNP Project is to increase provider confidence in screening, early detection rates and ultimately timely treatment for patients at risk for HCV served within a rural Federal Qualified Health center (FQHC).

Interventions for this project included bundle steps consisting of provider and staff training of Hepatitis C guidelines for screening, use of an Electronic Medical Records (EMR) HCV flowsheet and lab template, revision of preventative health form, and self-efficacy survey to evaluate provider and nursing confidence …

Sociological Explanations Of Coronavirus Incidence Rates In Kentucky Counties, Sarah Cooper, James N. Maples

Kentucky Journal of Undergraduate Scholarship

This study explores sociological explanations for Covid-19 incidence rates among Kentucky Counties. The authors examine how incidence rates varied pre/post-Omicron variant based on a county’s educational attainment, poverty rates, political perspective, health status, and place status (Appalachian status, metropolitan status). The authors discovered that none of these variables effectively explained differences in county level Covid-19 rates before Omicron. However, once Omicron became the prevalent variant in Kentucky, metropolitan status, Appalachian status, two measures of poverty rates, political perspective, and three measure of educational attainment all predicted differences in mean Covid-19 incidence rates.

On The Measure Of Noncompactness In $L_P(\Mathbb{R}^+)$ And Applications To A Product Of $N$-Integral Equations, Mohamed M. A. Metwali, Vishnu Narayan Mishra

Turkish Journal of Mathematics

In this article, we prove a new compactness criterion in the Lebesgue spaces $L_p({\mathbb{R}}^+), 1 \leq p < \infty$ and use such criteria to construct a measure of noncompactness in the mentioned spaces. The conjunction of that measure with the Hausdroff measure of noncompactness is proved on sets that are compact in finite measure. We apply such measure with a modified version of Darbo fixed point theorem in proving the existence of monotonic integrable solutions for a product of $n$-Hammerstein integral equations $n\geq 2$.

Viral Kinetics Of Sequential Sars-Cov-2 Infections, Stephen M. Kissler, James A. Hay, Joseph R. Fauver, Christina Mack, Caroline G. Tai, Deverick J. Anderson, David D. Ho, Nathan D. Grubaugh, Yonatan H. Grad

Journal Articles: Epidemiology

The impact of a prior SARS-CoV-2 infection on the progression of subsequent infections has been unclear. Using a convenience sample of 94,812 longitudinal RT-qPCR measurements from anterior nares and oropharyngeal swabs, we identified 71 individuals with two well-sampled SARS-CoV-2 infections between March 11^th, 2020, and July 28^th, 2022. We compared the SARS-CoV-2 viral kinetics of first vs. second infections in this group, adjusting for viral variant, vaccination status, and age. Relative to first infections, second infections usually featured a faster clearance time. Furthermore, a person's relative (rank-order) viral clearance time, compared to others infected with the …

Engaging The Aging Process: Unlock The Fountain Of Youth, Abeni El-Amin Ph.D.

Management Faculty Publications

Employment for aging is a significant aspect shaping the aging processes during formative years. Therefore, work opportunities combined and consequential impacts later in life merit special consideration. Given that population aging has become a global pattern with ensuing changes in labor markets far and wide, there is increased concern about the impacts of retirement around the globe and the macroeconomic advantages frequently connected with delaying retirement. It is fundamental for nations with aging populations to maintain profitability, given an aging workforce. Governments must make it simpler for individuals to maintain a significant presence in the workforce. This contribution focuses on …

2023 Intersession Catalog, Illinois Math And Science Academy

Intersession Catalogs

No abstract provided.