Digital Commons Network^™

Predicting Mobility Using Limited Data During Early Stages Of A Pandemic, Michael T. Lash, S. Sajeesh, Özgür M. Araz

Department of Marketing: Faculty Publications

The COVID-19 pandemic has changed consumer behavior substantially. In this study, we explore the drivers of consumer mobility in several metropolitan areas in the United States under the perceived risks of COVID-19. We capture multiple dimensions of perceived risk using local and national cases and death counts of COVID-19, along with real-time Google Trends data for personal protective equipment (PPE). While Google Trends data are popular inputs in many studies, the risk of multicollinearity escalates with the addition of more relevant terms. Therefore, multicollinearity-alleviating methods are needed to appropriately leverage information provided by Google Trends data. We develop and utilize …

A Preliminary Volterra Lotka Model Analysing Cancer, Intracellular Parasite, And Immune Cells Interaction, Nadia Boutabba, Gehan Abuelenain

Applied Mathematics & Information Sciences

In this paper, we investigate the dynamics of immune and tumor cell densities in the presence of a parasite using the prey- predator Volterra-Lotka model in a biological system, assuming that the parasite is either a down or up-regulator of the induced immune cells. Thus, we analysed the model for equal and non equal initial conditions and report their impact on the populations growth.

2022 Annual Campus Safety And Fire Report, Department Of Public Safety, University Of Nebraska At Omaha And Unmc

Public Safety Reports

The 2022 Annual Campus Safety and Fire Report (ASR) includes safety and fire information for the University of Nebraska Omaha and the University of Nebraska Medical Center, including crime & fire statistics for the 2021 calendar year, and the information required by the Drug‐Free Schools and Communities Act of 1989. All data is submitted to the U.S. Department of Education according to law. The University of Nebraska Department of Public Safety’s (UNDPS) provides services to the University campus community 24‐hours a day. Please call 402.554.2648 for information regarding any service offered by the UNDPS. The University of Nebraska shall not …

Estimating The Prevalence Of Two Or More Diseases Using Outcomes From Multiplex Group Testing, Md S. Warasi, Joshua M. Tebbs, Christopher S. Mcmahan, Christopher R. Bilder

Department of Statistics: Faculty Publications

When screening a population for infectious diseases, pooling individual specimens (e.g., blood, swabs, urine, etc.) can provide enormous cost savings when compared to testing specimens individually. In the biostatistics literature, testing pools of specimens is commonly known as group testing or pooled testing. Although estimating a population-level prevalence with group testing data has received a large amount of attention, most of this work has focused on applications involving a single disease, such as human immunodeficiency virus. Modern methods of screening now involve testing pools and individuals for multiple diseases simultaneously through the use of multiplex assays. Hou et al. (2017, …

Ada Code Of Ethics (March 2023), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.

Ga4gh Phenopackets: A Practical Introduction., Markus S Ladewig, Julius O B Jacobsen, Alex H Wagner, Daniel Danis, Baha El Kassaby, Michael Gargano, Tudor Groza, Michael Baudis, Robin Steinhaus, Dominik Seelow, Nikolaos E Bechrakis, Christopher J Mungall, Paul N Schofield, Olivier Elemento, Lindsay Smith, Julie A Mcmurry, Monica Munoz-Torres, Melissa A Haendel, Peter N Robinson

Faculty Research 2023

The Global Alliance for Genomics and Health (GA4GH) is developing a suite of coordinated standards for genomics for healthcare. The Phenopacket is a new GA4GH standard for sharing disease and phenotype information that characterizes an individual person, linking that individual to detailed phenotypic descriptions, genetic information, diagnoses, and treatments. A detailed example is presented that illustrates how to use the schema to represent the clinical course of a patient with retinoblastoma, including demographic information, the clinical diagnosis, phenotypic features and clinical measurements, an examination of the extirpated tumor, therapies, and the results of genomic analysis. The Phenopacket Schema, together with …

Conventional Methods And Future Trends In Antimicrobial Susceptibility Testing, Md Abdus Salam, Md Yusuf Al-Amin, Jogendra Singh Pawar, Naseem Akhter, Irine Banu Lucy

Neurology Articles

Antimicrobial susceptibility testing is an essential task for selecting appropriate antimicrobial agents to treat infectious diseases. Constant evolution has been observed in methods used in the diagnostic microbiology laboratories. Disc diffusion or broth microdilution are classical and conventional phenotypic methods with long turnaround time and labour-intensive but still widely practiced as gold-standard. Scientists are striving to develop innovative, novel and faster methods of antimicrobial susceptibility testing to be applicable for routine microbiological laboratory practice and research. To meet the requirements, there is an increasing trend towards automation, genotypic and micro/nano technology-based innovations. Automation in detection systems and integration of computers …

Paragonimiasis Misdiagnosed As Pulmonary Tuberculosis: A Case Report, Renzo Villanueva-Villegas, Javier Diaz-Mendoza, Juan Salas-Lopez, Carlos Espiche

Pulmonary and Critical Care Medicine Articles

Paragonimiasis is a zoonosis caused by the ingestion of raw or undercooked crustaceans parasitized with metacercaria of Paragonimus spp. In Peru, Cajamarca is considered an endemic region for paragonimiasis. A 29-year-old man from the department of San Martín, Peru presented with a three-year history of cough, chest pain, fever, and hemoptysis. Treatment for tuberculosis (TB) was initiated even with negative results for sputum acid-fast bacillus (AFB), due to the patient's clinical characteristics and the high prevalence of the condition in the region. After eight months, due to the lack of any clinical improvement, he was referred to a regional hospital, …

March 2023 Cvm Library Newsletter

CVM Library Newsletters

March 2023 CVM Library Newsletter

Vaccine Politics: Comparison Of Acceptance Of Covid-19 Vaccines Produced By Democratic And Non-Democratic Countries, Akbar Fasya Habibilla, Adhi Cahya Fahadayna

Jurnal Politik

The unequal distribution of the COVID-19 vaccine worldwide is one of humanity's global challenges due to political factors entering and influencing the distribution of vaccines to countries worldwide. Vaccine-producing countries are fragmented into two sides: democratic and non-democratic countries. This article aims to answer how political factors can influence the distribution of the COVID-19 vaccine globally and which vaccine is the global favorite. This article uses vaccine politics theory as its basis and uses descriptive-comparative methods in the data analysis process. The results of this research found that there were indications that illiberal democratic practices were widespread during the COVID-19 …

Impact Of The Dimethyl Sulfoxide Reductase Superfamily On The Evolution Of Biogeochemical Cycles, Michael Wells, Minjae Kim, Denise M. Akob, Partha Basu, John F. Stolz

UK CARES Faculty Publications

The dimethyl sulfoxide reductase (or MopB) family is a diverse assemblage of enzymes found throughout Bacteria and Archaea. Many of these enzymes are believed to have been present in the last universal common ancestor (LUCA) of all cellular lineages. However, gaps in knowledge remain about how MopB enzymes evolved and how this diversification of functions impacted global biogeochemical cycles through geologic time. In this study, we perform maximum likelihood phylogenetic analyses on manually curated comparative genomic and metagenomic data sets containing over 47,000 distinct MopB homologs. We demonstrate that these enzymes constitute a catalytically and mechanistically diverse superfamily defined not …

Genetic Mapping Of Microbial And Host Traits Reveals Production Of Immunomodulatory Lipids By Akkermansia Muciniphila In The Murine Gut., Qijun Zhang, Vanessa Linke, Katherine A Overmyer, Lindsay L Traeger, Kazuyuki Kasahara, Ian J Miller, Daniel E Manson, Thomas J Polaske, Robert L Kerby, Julia H Kemis, Edna A Trujillo, Thiru R Reddy, Jason D Russell, Kathryn L Schueler, Donald S Stapleton, Mary E Rabaglia, Marcus Seldin, Daniel M Gatti, Gregory R Keele, Duy T Pham, Joseph P Gerdt, Eugenio I Vivas, Aldons J Lusis, Mark P Keller, Gary Churchill, Helen E Blackwell, Karl W Broman, Alan D Attie, Joshua J Coon, Federico E Rey

Faculty Research 2023

The molecular bases of how host genetic variation impacts the gut microbiome remain largely unknown. Here we used a genetically diverse mouse population and applied systems genetics strategies to identify interactions between host and microbe phenotypes including microbial functions, using faecal metagenomics, small intestinal transcripts and caecal lipids that influence microbe-host dynamics. Quantitative trait locus (QTL) mapping identified murine genomic regions associated with variations in bacterial taxa; bacterial functions including motility, sporulation and lipopolysaccharide production and levels of bacterial- and host-derived lipids. We found overlapping QTL for the abundance of Akkermansia muciniphila and caecal levels of ornithine lipids. Follow-up in …

Making Morbidity Multiple: History, Legacies, And Possibilities For Global Health, Justin Dixon, Emily Mendenhall, Edna Bosire, Felix Limbani, Rashida A. Ferrand, Clare I R. Chandler

Brain and Mind Institute

Multimorbidity has been framed as a pressing global health challenge that exposes the limits of systems organised around single diseases. This article seeks to expand and strengthen current thinking around multimorbidity by analysing its construction within the field of global health. We suggest that the significance of multimorbidity lies not only in challenging divisions between disease categories but also in what it reveals about the culture and history of transnational biomedicine. Drawing on social research from sub-Saharan Africa to ground our arguments, we begin by describing the historical processes through which morbidity was made divisible in biomedicine and how the …

Why Some People Are Hesitant To Receive Covid-19 Boosters: A Systematic Review, Yam B. Limbu, Bruce A. Huhmann

Department of Marketing Faculty Scholarship and Creative Works

As the COVID-19 pandemic continues and transitions to an endemic stage, booster vaccines will play an important role in personal and public health. However, convincing people to take boosters continues to be a key obstacle. This study systematically analyzed research that examined the predictors of COVID-19 booster vaccine hesitancy. A search of PubMed, Medline, CINAHL, Web of Science, and Scopus uncovered 42 eligible studies. Globally, the average COVID-19 booster vaccination hesitancy rate was 30.72%. Thirteen key factors influencing booster hesitancy emerged from the literature: demographics (gender, age, education, income, occupation, employment status, ethnicity, and marital status), geographical influences (country, region, …

A Draft Of The Genome Of The Gulf Coast Tick, Amblyomma Maculatum, Jose M.C. Ribeiro, Natalia J. Bayona-Vásquez, Khemraj Budachetri, Deepak Kumar, Julia Catherine Frederick, Faizan Tahir, Brant C. Faircloth, Travis C. Glenn, Shahid Karim

Faculty Publications

The Gulf Coast tick, Amblyomma maculatum, inhabits the Southeastern states of the USA bordering the Gulf of Mexico, Mexico, and other Central and South American countries. More recently, its U.S. range has extended West to Arizona and Northeast to New York state and Connecticut. It is a vector of Rickettsia parkeri and Hepatozoon americanum. This tick species has become a model to study tick/Rickettsia interactions. To increase our knowledge of the basic biology of A. maculatum we report here a draft genome of this tick and an extensive functional classification of its proteome. The DNA from a single …

Ideal Cardiovascular Health, Biomarkers, And Coronary Artery Disease In Persons With Hiv, Pamela S Douglas, Sara Mccallum, Michael T Lu, Triin Umbleja, Kathleen V Fitch, Borek Foldyna, Markella V Zanni, Evelynne S Fulda, Gerald S Bloomfield, Carl J Fichtenbaum, Edgar T Overton, Judith A Aberg, Carlos D Malvestutto, Tricia H Burdo, Roberto C Arduino, Ken S Ho, Michael T Yin, Heather J Ribaudo, Steven K Grinspoon

Faculty, Staff and Student Publications

OBJECTIVE: To investigate relationships between Life's Simple 7 (LS7), an assessment of cardiovascular health (CVH), and coronary plaque among people with HIV (PWH).

DESIGN: Cross-sectional.

METHODS: Coronary computed tomography angiography, immune/inflammatory biomarkers, and characterization of LS7 were collected among a subset of ART-treated PWH enrolled in REPRIEVE, a primary prevention trial. Analyses adjusted for cardiovascular disease risk (ASCVD score).

RESULTS: Median age of the 735 participants was 51(±6) years, 16% female, and median (Q1-Q3) CVD risk was 4.5% (2.6-6.9). Forty percent had poor (≤2 ideal components), 51% had intermediate (three or four ideal components), and only 9% had ideal CVH …

Implementation Of Evidence-Based Multiple Focus Integrated Intensified Tb Screening To End Tb (Exit-Tb) Package In East Africa: A Qualitative Study, Kahabi Isangula, Doreen Philbert, Florence Ngari, Tigest Ajeme, Godfather Kimaro, Getnet Yimer, Nicholaus P. Mnyambwa, Winters Muttamba, Irene Najjingo, Aman Wilfred

School of Nursing & Midwifery, East Africa

Introduction Tuberculosis (TB) remains a major cause of morbidity and mortality, especially in sub-Saharan Africa. We qualitatively evaluated the implementation of an Evidence-Based Multiple Focus Integrated Intensified TB Screening package (EXIT-TB) in the East African region, aimed at increasing TB case detection and number of patients receiving care.

Objective We present the accounts of participants from Tanzania, Kenya, Uganda, and Ethiopia regarding the implementation of EXIT-TB, and suggestions for scaling up.

Methods A qualitative descriptive design was used to gather insights from purposefully selected healthcare workers, community health workers, and other stakeholders. A total of 27, 13, 14, and 19 …

Risk Factors For Seizure Recurrence After Initial Withdrawal Of Anti-Seizure Medications In Children With Epilepsy At Aga Khan University Hospital, Nairobi, Kenya, Nicholas Odero, Katherine Oyieke, Sanson Gwer, Pauline Samia

Paediatrics and Child Health, East Africa

Objectives: We sought to determine risk factors associated with seizure recurrence following initial withdrawal of anti-seizure medications (ASM) among children with epilepsy.

Methods: This was a retrospective observational study of children aged between 2 and 18 years with a diagnosis of epilepsy who underwent withdrawal of anti-seizure medication following remission of seizures. All eligible medical records between January 2011 and December 2019 were included. Demographic, clinical, imaging and electroencephalography data of all eligible patients were analyzed against seizure remission within 24 months after withdrawal of ASM, using appropriate parametric and non-parametric tests.

Results: A total of 49 …

Justice System Contact And Health: Do Immigrants Fair Better Or Worse Than The Native-Born After Arrest, Probation, Or Incarceration?, Casey T. Harris, Michael Nino, Zhe (Meredith) Zhang, Mia Robert

Sociology and Criminology Faculty Publications and Presentations

Despite decades of both macro- and micro-level studies showing immigration to be unassociated or negatively linked to crime, research examining the consequences of justice system contact among immigrants has been comparatively underdeveloped. The current study examines whether justice system contact (arrest, probation, and incarceration) is linked to poorer health and, in turn, whether there were differences in how justice system contact is related to immigrant versus native-born health. Using data from multiple waves of the National Longitudinal Study of Adolescent to Adult Health (Add Health), we construct both ordinal and Poisson regression models predicting poor self-rated health and the prevalence …

Policing Pregnancy "Crimes", Valena Beety, Jennifer Oliva

Articles by Maurer Faculty

The Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization held that there is no right to abortion healthcare under the United States Constitution. This Essay details how states prosecuted pregnant people for pregnancy behaviors and speculative fetal harms prior to the Dobbs decision. In this connection, it also identifies two, related post-Dobbs concerns: (1) that states will ramp up their policing of pregnancy behaviors and (2) that prosecutors will attempt to substantiate these charges by relying on invalid scientific evidence. This Essay examines the faulty forensic science that states have used to support fetal harm allegations and reminds …

The Complication Of Cyber Manhunt: How Cyber Manhunt Further Complicated The Ethical Conflict Between Breaching The Confidentiality And Endangering The Society In Face Of The Covid-19 Pandemic, Yen-Chang Chen, Yen-Yuan Chen

Journal of Medical Education

While health care and public health workers are working on measures to mitigate the COVID-19 pandemic, there is an unprecedentedly large number of people spending much more time indoors, and relying heavily on the Internet as their lifeline. What has been overlooked is the influence of the increasing online activities on public health issues. In this article, we pointed out how a large-scale online activity called cyber manhunt may threaten to offset the efficacy of contact tracing investigation, a public health intervention considered highly effective in limiting further transmission in the early stage of a highly contagious disease outbreak such …

Current Status And Future Perspective Of Hospital Medicine In Medical Education, Nin-Chieh Hsu, Chia-Lin Tseng, Yu-Feng Lin, Tzung-Dau Wang, Wang-Huei Sheng

Journal of Medical Education

Hospital medicine emerged in the United States in the 1990s to cope with the growing need for integrated care for complex and ageing hospitalized patients. The hospitalist model has rapidly spread out worldwide to European and Asian countries. It was also introduced to Taiwan in 2009 and obtained the government support since 2015 with a pilot project among more than two thirds of medical centers. Hospital medicine has also involved in medical education in the US, with medical schools and residency programs offer dedicated training in hospital medicine. Hospital medicine aims to provide a highly coordinated, patient-and-family-centered, goal-directed care to …

A Potent And Broad Neutralization Of Sars-Cov-2 Variants Of Concern By Darpins, Vikas Chonira, Young D Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens, Lawrence Shapiro, Michael F Bender, Hannah Boyd, I-Ting Teng, Yaroslav Tsybovsky, Florian Krammer, Ningyan Zhang, Michael S Diamond, Peter D Kwong, Zhiqiang An, Zhilei Chen

Faculty, Staff and Student Publications

We report the engineering and selection of two synthetic proteins-FSR16m and FSR22-for the possible treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. FSR16m and FSR22 are trimeric proteins composed of DARPin SR16m or SR22 fused with a T4 foldon. Despite selection by a spike protein from a now historical SARS-CoV-2 strain, FSR16m and FSR22 exhibit broad-spectrum neutralization of SARS-CoV-2 strains, inhibiting authentic B.1.351, B.1.617.2 and BA.1.1 viruses, with respective IC

Ivd Delivery System, Brandon Low, Jonathan Li, Margaux Faure, Quentin Yamasaki

Mechanical Engineering

Cepheid is a molecular diagnostics company that has assigned our senior project team to design a system that automates the current manual transportation of samples between two laboratory rooms. With the focus of retaining the sanitary integrity of both the samples as well as the initial cleanroom, also referred to as the packaging laboratory, our team has designed an extension of the current passthrough that will contain all other subsystems. In order to automate the transportation of the samples, the design employs a track and trolley system to be purchased and mounted within the passthrough. A verification prototype was built …

Best Practices For Surface Disinfection, Khrystyna Vyprynyuk

Publications and Research

No abstract provided.

Ferric Chloride-Induced Arterial Thrombosis And Sample Collection For 3d Electron Microscopy Analysis, Smita Joshi, Alexis N. Smith, Kanakanagavalli Shravani Prakhya, Hammodah Rawhi Hammodah Alfar, Joshua Lykins, Ming Zhang, Irina D. Pokrovskaya, Maria A. Aronova, Richard D. Leapman, Brian Storrie, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Aberrant thrombosis is a common feature of systemic conditions like diabetes and obesity, and chronic inflammatory diseases like atherosclerosis, cancer, and autoimmune diseases. Upon vascular injury, usually the coagulation system, platelets, and endothelium act in an orchestrated manner to prevent bleeding by forming a clot at the site of the injury. Abnormalities in this process lead to either excessive bleeding or uncontrolled thrombosis/insufficient antithrombotic activity, which translates into vessel occlusion and its sequelae. The FeCl3-induced carotid injury model is a valuable tool in probing how thrombosis initiates and progresses …

Results Of The 2022 Immunization Status Survey Of 24-Month-Old Children In Tennessee, Tennessee. Department Of Health.

Immunization Rates

No abstract provided.

Multimorbidity Research In Sub-Saharan Africa: Proceedings Of An Interdisciplinary Workshop, Gift T. Banda, Edna Bosire, Christopher Bunn, Clare I.R. Chandler, Edith Chikumbu, Jonathan Chiwanda, Justin Dixon, Rashida A. Ferrand, Andre-Pascal Kengne, Felix Limbani

Brain and Mind Institute

As life expectancies rise globally, the number of people living with multiple chronic health conditions – commonly referred to as ‘multimorbidity’ – is rising. Multimorbidity has been recognised as especially challenging to respond to in countries whose health systems are under-funded, fragmented, and designed primarily for acute care, including in sub-Saharan Africa. A growing body of research in sub-Saharan Africa has sought to better understand the particular challenges multimorbidity poses in the region and to develop context-sensitive responses. However, with multimorbidity still crystallising as a subject of enquiry, there remains considerable heterogeneity in conceptualising multimorbidity across disciplines and fields, hindering …

A Comparative Analysis Of Viral Aerosol Biological Sampling Efficiency Of A Small Unmanned Aircraft System (Suas)-Mounted Aerosol Sampler And A Reference Static Biosampler®, Jonathan D. Moroz

Theses and Dissertations

Bioaerosol sampling using small unmanned aerial systems (sUAS) is a rapidly developing field that may result in a paradigm shift in emergency response and industrial hygiene sampling conventions. These technologies offer decreased sample acquisition times, larger sampling area coverage, and reduced health and safety risks to traditional human sampling teams. This potential requires a comprehensive investigation of sUAS capabilities and limitations. This study is a continuation of the characterization of an AFIT-developed sUAS-mounted aerosol sampler, proven capable of collecting viable vegetative and spore-forming bacteria through previous AFIT research. Within this study, viral biological sampling efficiency (BSE) of the sUAS-mounted aerosol …

Library News March 2023, Research Medical Library

Library News 2023

• Clinical Tools for Making Fast, Precise Decisions and Earning CME Credits
• Finding Examples of Funded NIH Applications
• WHO Blue Books – Classification of Tumours Online
• EndNote 20 Is Available
• Good Advice on the Use of “Good” vs. “Well”