Digital Commons Network^™

Dominant Negative Variants In Ikzf2 Cause Ichad Syndrome, A New Disorder Characterized By Immunodysregulation, Craniofacial Anomalies, Hearing Impairment, Athelia, And Developmental Delay, Arezoo Mohajeri, Maryam Vaseghi-Shanjani, Jill A Rosenfeld, Gui Xiang Yang, Henry Lu, Mehul Sharma, Susan Lin, Areesha Salman, Meriam Waqas, Mahshid Sababi Azamian, Kim C Worley, Kate L Del Bel, Frederick K Kozak, Ronak Rahmanian, Catherine M Biggs, Kyla J Hildebrand, Seema R Lalani, Sarah K Nicholas, Daryl A Scott, Sara Mostafavi, Clara Van Karnebeek, Erika Henkelman, Jessica Halparin, Connie L Yang, Linlea Armstrong, Undiagnosed Diseases Network, Anna Lehman Care 4 Rare Canada Consortium, Stuart E Turvey

Faculty, Staff and Students Publications

Background:

Helios (encoded by IKZF2), a member of the Ikaros family of transcription factors, is a zinc finger protein involved in embryogenesis and immune function. Although predominantly recognized for its role in the development and function of T lymphocytes, particularly the CD4⁺ regulatory T cells (Tregs), the expression and function of Helios extends beyond the immune system. During embryogenesis, Helios is expressed in a wide range of tissues, making genetic variants that disrupt the function of Helios strong candidates for causing widespread immune-related and developmental abnormalities in humans.

Methods:

We performed detailed phenotypic, genomic, and functional investigations on …

Divulging Two Decades Of Multimedia Applications In Biology Education, Khairul Hafezad Abdullah

Jurnal Inovasi Pendidikan IPA

Biology is an indispensable component of Science, Technology, Engineering, and Mathematics (STEM) education. Accordingly, effective biology teaching necessitates multimedia to assist students in fathoming complex scientific themes. This study aims to scrutinise the bibliometrics of preceding publications on multimedia applications in biology education from the Scopus and Web of Science databases. This study explores descriptive publishing patterns and the emergence of academic discourse about multimedia applications in biology education using ScientoPy and VOSviewer. The results reveal publications on this topic have been volatile, with less than ten publications in both databases. The United States has bested others as the most …

Synchronized Communication Used In Collaborative Humanoid Robots With Datacenter Applications, Fatih Dincer, Ahmad Byagowy

UBT International Conference

This manuscript is to describe a communication method used to operate data center related applications where multiple robots are required. In this configuration one of the robots is considered as the leader while the other one performs as a follower. The operations performed from the collective operation of the two robots aim to reach a coherence to allow applications that require multiple robots to be performed seamlessly. The development of this work was based on humanoid robots though it can be expanded to any robot platform based on a given application.

International Conference On Mechatronic, University For Business And Technology - Ubt

UBT International Conference

UBT Annual International Conference is the 12th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make them be aware of the recent …

The Acute Impacts Of Resistance Training Performed With And Without Blood Flow Restriction On Lower Body Muscular Power, Justin Faller, Brian Thompson, Stephen Ives

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 1320-1333, 2023. The American College of Sports Medicine recommends resistance training using at least 70% one repetition maximum to improve muscular strength and hypertrophy; however, these intensities may not be safe for all populations. A training technique that has been reported to elicit increases in strength and muscle size uses low intensity resistance training or low load training in combination with blood flow restriction (BFR) to the working muscle. Although the acute effects of BFR on muscle strength and size are well established, the effects of BFR on muscular power are not definitively known. …

Knowledge Integration In Domain-Informed Machine Learning And Multi-Scale Modeling Of Nonlinear Dynamics In Complex Systems, Phat K. Huynh

USF Tampa Graduate Theses and Dissertations

Nonlinear dynamical systems have been extensively used to model various phenomena in the changing world around us, especially in science and engineering fields. Thanks to breakthrough advancements in sensing technologies, an increasingly high volume of multi-modal sensor data has been collected, which enables us gain better insights into complex systems dynamics and build sophisticated data-driven machine-learning-based dynamic models without having the access to the underlying governing equations. However, integrating domain-specific knowledge in machine learning algorithms remains pivotal for various reasons: it promises enhanced predictive accuracy, better model interpretability, and increased generalizability. This dissertation delves into three core research questions, each …

Tolkien Dogmatics: Theology Through Mythology With The Maker Of Middle-Earth By Austin M. Freeman, Alex (Oleksiy) Ostaltsev

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

The powerful and highly informative definitions that Freeman applies to Tolkien’s Middle-earth phenomenon in the title of his book create a productive interpretational framework. Myth and mythology in Inklings’ writing were always understood, in an almost Jungian way, as a cultural paradigm flexible enough to embrace the free creativity of the playful human mind and a philosophical postulate, or credo, of the humanistic religious intuition of Christianity. In Freeman’s interpretation, Tolkien’s literary myth in some ways requires a theological background, which, in its turn, leads to inevitable dogma, a statement that reveals the sensitive mechanics of literary myth as it …

Neuroprotective Activity Of Enantiomers Of Salsolinol And N-Methyl-(R)-Salsolinol: In Vitro And In Silico Studies, Magdalena Kurnik-Łucka, Gniewomir Latacz, Adam Bucki, Mario Rivera-Meza, Nadia Khan, Jahnobi Konwar, Kamil Skowron, Marcin Kołaczkowski, Krzysztof Gil

Faculty, Staff and Student Publications

Salsolinol (1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol) is a close structural analogue of dopamine with an asymmetric center at the C1 position, and its presence in vivo, both in humans and rodents, has already been proven. Yet, given the fact that salsolinol colocalizes with dopamine-rich regions and was first detected in the urine of Parkinson's disease patients, its direct role in the process of neurodegeneration has been proposed. Here, we report that

Determining The Protective Effect Of A Boron Adjuvanted Vaccine With An Experimental Infection Model In Mice, Zafer Sayin, Ali̇ Uslu, Özgür Özdemi̇r, Abdullah Başoğlu, Asli Balevi̇, Uçkun Sai̇t Uçan, Zeki̇ Aras, Osman Ergani̇ş

Turkish Journal of Veterinary & Animal Sciences

Boron is a required trace element for plants, humans, and animals and it has significant influence over biological functions and the immune system. Vaccines have aided humans in the control of many contagious diseases around the world. The success of global immunization campaigns may be possible with the development of effective and low-cost vaccines and adjuvants. For this reason, the present study aimed to determine the adjuvant activity of easily accessible boron compounds. In this study, six different vaccines were prepared, including inactive Staphylococcus aureus bacteria, boric acid, aluminum hydroxide, montanide ISA 50, and ISA 206, ISA 50 + boric …

A Descriptive Exploration Of Quality And Opportunities In Outdoor Urban Play Spaces: The Case Of Chicago Public Schools, Katherine Anne Varey

Dissertations

This study investigated the quality of children’s play spaces, both green and built, in and surrounding urban public schools in Chicago. Given children’s declining access to nature and the outdoors, especially in urban areas, the aim of the study was to both assess the current potential for high-quality outdoor experiences, as well as to uncover additional, low-cost, and low-burden opportunities that may exist for enhancing outdoor experiences. Based on a selected sample of 60 Chicago Public Schools, this mixed methods study employed quantitative ratings of play space and neighborhood quality, geographic information systems (GIS) mapping techniques to show distribution of …

Investigating The Influence Of Assessment Question Framing On Undergraduate Biology Student Preference And Affect, Jeremy L. Hsu, Noelle Clark, Kate Hill, Melissa Rowland-Goldsmith

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nearly all undergraduate biology courses rely on quizzes and exams. Despite their prevalence, very little work has been done to explore how the framing of assessment questions may influence student performance and affect. Here, we conduct a quasi-random experimental study where students in different sections of the same course were given isomorphic questions that varied in their framing of experimental scenarios. One section was provided a description using the self-referential term “you”, placing the student in the experiment; another section received the same scenario that used classmate names; while a third section's scenario integrated counterstereotypical scientist names. Our results demonstrate …

Play With Data: Using Haptic Properties Of Artifacts To Augment Data Representation, Xiang Wei, Lin Siyuan, Jiang Hao, Zhao Shengdong, Sun Lingyun

IASDR Conference Series

This article explores haptic data representation of people’s daily activities. The haptic data representation employs haptic properties of artifacts to represent data. However, the data types represented by haptic properties appear to be constrained, with frequency and average value accounting for the majority. Many other valuable types of information, such as variance, trend, and sample size, are under-represented. These data types are important for people to make decisions and reflect on their activities. To explore the potentials of expressing multiple data types through various haptic properties of artifacts, a user study was conducted to investigate people’s mental mappings of haptic …

Volume 1, Issue 6, Bryant University

Bryant Bulldog Bulletin (2023-2024)

No abstract provided.

October 4, 2023 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Global Impact Of Proteoglycan Science On Human Diseases, Christopher Xie, Liliana Schaefer, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss …

Wearable Sensor-Based Walkability Assessment At Ferry Terminal Using Machine Learning: A Case Study Of Mokpo, Korea, Jungyeon Choi, Hwayoung Kim

Journal of Marine Science and Technology–Taiwan

Walkability assessments are becoming more popular, as walking offers numerous health, environmental, and economic benefits to communities. However, previous studies on ferry terminal walkability assessment have been inadequate. This study aimed to develop a wearable sensor system to automatically assess walkability at ferry terminals without conducting surveys. We applied seven machine learning (ML) classifiers to detect different walking environments, including flat ground (FG), downhill slope (DS), uphill slope (US), and uneven surface (UE). The ML models were evaluated across different combinations of classes: 2-class (FG vs. UE), 3-class (U) (FG vs. US vs. UE), 3-class (D) (FG vs. DS vs. …

An Alternative Strategy For Fabrication Of Robust And Flexible Digital Microfluidic Devices, Nathaniel Thorne, Melissa Lamberto, Audrey Mazza, Sergio Freire

International Journal of Undergraduate Research and Creative Activities

We present a new strategy for the fabrication of digital microfluidic (DMF) devices by research groups without access to well-equipped facilities. Compared to previously developed methods, it increases considerably device yield, and yet simplifies fabrication and enables flexible operation.To this end, we use large (260 and 400 μm) interelectrode gaps to optimize substrate fabrication, breaking the established constraint that gap dimensions must be small (usually < 150 μm) for digital microfluidics. In fact, we show that interelectrode gaps are not limiting features for DMF performance, and may be quite large (> 1 mm). Smooth droplet actuation is ensured by films of perfluoroalkoxy (PFA), which do not require additional coatings; films can be instantly replaced, without the necessity of annealing. Finally, our tests indicate that DMF devices …

The Effects Of Accessory Blood Flow Restriction Training On Muscle Size And Strength In Division Iii Soccer Athletes: A Preliminary Ecological Study, Kaitlyn Judd, Christian Morales, Megan White, Kate Wilkie, Justin Faller, Stephen Ives

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 1244-1256, 2023. Blood flow restriction training (BFRT) uses occlusion during low-intensity resistance training (< 50% of 1-repetition maximum, 1RM) to reduce arterial blood flow and venous return, imposing greater metabolic stress but similar muscular hypertrophy and strength gains as high-intensity resistance training (HIRT). However, no study, to date, has incorporated BFRT in a collegiate strength and conditioning setting to assess ecological validity. We aimed to investigate the effects of adding 6-weeks of accessory BFRT or HIRT to NCAA Division III soccer players prescribed resistance training regimen on muscle strength and size. Male and female (n = 17) athletes were randomly assigned to complete biceps curls 2x/week under BFRT or control (HIRT), following regularly scheduled strength training. Bicep strength (1RM) and circumference (BC) were assessed at weeks 0, 3, and 6 (men only). In men, for BC no significant interaction of condition x time was observed (p = 0.861), though condition (BFRT vs Control, p = 0.025) and time (p = 0.024) were significant. For 1RM, there was no significant interaction of condition …

Reduction Of Sparc Protects Mice Against Nlrp3 Inflammasome Activation And Obesity, Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun-Hee Youm, Vishwa Deep Dixit

2020-Current year OA Pubs

The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous CR-mimetics that can be deployed to control obesity-associated inflammation and diseases are not well understood. Our studies have found that 2 years of 14% sustained CR in humans inhibits the expression of the matricellular protein, secreted protein acidic and rich in cysteine (SPARC), in adipose tissue. In mice, adipose tissue remodeling caused by weight loss through CR and low-protein diet feeding decreased, while high-fat diet-induced (HFD-induced) obesity increased SPARC expression …

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Cold-Water Immersion On Arterial Compliance, Rita M. Grigorian

Master's Theses

As the prevalence of cardiovascular diseases continues to exponentially grow in populations across the globe, the necessity of determining underlying factors, effective methods of diagnoses, and universally available preventive measures also grows. Early detection of endothelial dysfunction, a proven precursor of cardiovascular diseases, can be extremely impactful in encouraging preventative measures and early intervention before medical conditions become chronic. In recent years, ice plunging, a form of cryotherapy involving full body immersion in cold water, has gained popularity within circles of fitness and health practitioners, gaining the interest of people of all backgrounds. Certain parallels observed between the human physiological …

G Protein-Coupled Receptors: A Target For Microbial Metabolites And A Mechanistic Link To Microbiome-Immune-Brain Interactions, Gajender Aleti, Emily A. Troyer, Suzi Hong

Agricultural and Environmental Sciences Faculty Research

Human-microorganism interactions play a key role in human health. However, the underlying molecular mechanisms remain poorly understood. Small-molecules that offer a functional readout of microbe-microbe-human relationship are of great interest for deeper understanding of the inter-kingdom crosstalk at the molecular level. Recent studies have demonstrated that small-molecules from gut microbiota act as ligands for specific human G protein-coupled receptors (GPCRs) and modulate a range of human physiological functions, offering a mechanistic insight into the microbe-human interaction. To this end, we focused on analysis of bacterial metabolites that are currently recognized to bind to GPCRs and are found to activate the …

Cluster - Fall 1999, Prairie View A&M University

Newsletter Collections

No abstract provided.

Yale Medicine Magazine Autumn 2023, Issue 171, Yale University. School Of Medicine

Yale Medicine Magazine - alumni bulletin and magazine

This is the Autumn 2023 issue of Yale Medicine Magazine, issue 171. Prepared in cooperation with the alumni and development offices at the School of Medicine. Earlier volumes are called Yale School of Medicine alumni bulletins, dating from v.1 (1953) through v.13 (1965) and Yale Medicine: alumni bulletin of the School of Medicine, v.1 (1965) through v. 52, no.1. (Autumn 2017).

Aba-Mandated Instruction On Racism And Recent State Legislation Banning Such Instruction In University Classrooms: “Jim Crow” Redux, Bernard K. Freamon

Law Faculty Scholarship

No abstract provided.

Innately Expressed Estrogen-Related Receptors In The Skeletal Muscle Are Indispensable For Exercise Fitness, Ashok Kumar, Vihang A Narkar

Faculty, Staff and Student Publications

Peripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular insufficiency, causing ischemic injury, mitochondrial metabolic damage and functional impairment in the skeletal muscle, and ultimately leading to immobility and mortality. While potential therapies have been mostly focussed on revascularization, none of the currently available pharmacological treatments are fully effective in PAD, often leading to amputations, particularly in chronic metabolic diseases. One major limitation of focussed angiogenesis and revascularization as a therapeutic strategy is a limited effect on metabolic restoration and muscle regeneration in the affected limb. Therefore, additional preclinical investigations are needed to discover novel treatment options …

Biopsychosocial Resilience Through A Complex Adaptive Systems Lens: A Narrative Review Of Nonlinear Modeling Approaches, Adam W. Kiefer, David Pincus

Psychology Faculty Articles and Research

Human resilience is often considered as static traits using a reductionist approach. More recent work has demonstrated it to be a dynamic and emergent property of complex systems. This narrative review explores human resilience through a self-organizing framework with a specific emphasis on the application of nonlinear modeling approaches. Four classes of approaches are examined: univariate dynamics, bivariate coupling, topological modeling, and network modeling. Univariate dynamics capture the temporal structure and flexibility within a single time series, while bivariate coupling approaches quantify the interaction dynamics and coordination between two time series. Topological modeling identifies bifurcations and attractor dynamics as signals …

Underrepresentation Of Women In Exercise Science And Physiology Research Is Associated With Authorship Gender, Jessica J. James, Emilie A. Klevenow, Mira A. Atkinson, Emma E. Vosters, Elizabeth P. Bueckers, Meagan E. Quinn, Samantha L. Kindy, Azara P. Mason, Sophia K. Nelson, Kennedy A. H. Rainwater, Petra V. Taylor, Elena P. Zippel, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Historically, low representation of women participants in exercise science and physiology studies has led to a lack of understanding in the response of women to exercise and therapeutic interventions. We hypothesized that 1) the number of women authors, participants, and editorial board members increased over 30 years (1991–2021) and 2) larger representation of women as editors and authors is associated with more women participants. Gender (man/woman) of editorial board members (n = 394), authors (n = 5,735), and participants (n = 2,984,883) of 972 original research articles with human participants published in 1991 and 2021 …

Nuclear Receptors As Potential Therapeutic Targets In Peripheral Arterial Disease And Related Myopathy, Ashok Kumar, Vihang A Narkar

Faculty, Staff and Student Publications

Peripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular insufficiency, causing ischemic injury, mitochondrial metabolic damage and functional impairment in the skeletal muscle, and ultimately leading to immobility and mortality. While potential therapies have been mostly focussed on revascularization, none of the currently available pharmacological treatments are fully effective in PAD, often leading to amputations, particularly in chronic metabolic diseases. One major limitation of focussed angiogenesis and revascularization as a therapeutic strategy is a limited effect on metabolic restoration and muscle regeneration in the affected limb. Therefore, additional preclinical investigations are needed to discover novel treatment options …

Seminar: Extracellular Vesicles As Mediators Of Environmental Stress In Human Disease, Vrinda Kalia, Andrea A Baccarelli, Christine Happel, Jonathan A Hollander, Anne Marie Jukic, Kimberly A Mcallister, Ramkumar Menon, Bruce A Merrick, Aleksander Milosavljevic, Lingamanaidu V Ravichandran, Matthew E Roth, Anita Subramanian, Frederick L Tyson, Leroy Worth, Daniel T Shaughnessy

Faculty, Staff and Students Publications

Background: Extracellular vesicles (EVs), membrane-bound particles containing a variety of RNA types, DNA, proteins, and other macromolecules, are now appreciated as an important means of communication between cells and tissues, both in normal cellular physiology and as a potential indicator of cellular stress, environmental exposures, and early disease pathogenesis. Extracellular signaling through EVs is a growing field of research for understanding fundamental mechanisms of health and disease and for the potential for biomarker discovery and therapy development. EVs are also known to play important roles in mediating the effects of exposure to environmental stress.

Objectives: This seminar addresses the application …

"The Rat Trap" By Pandora Pound, Andrew Rowan

Tales of WellBeing

The book critically analyzes animal research and argues for greater emphasis on human cell technologies and clinical research.