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Uab Apsa Partnership With Birmingham Ymca Ignites Curiosity About Science Using Experiments, Hands-On Activities, Liann Cates

Browse All News

No abstract provided.

The Effect Of Depression On Bone Mineral Density In College-Aged Females, Caitlin A. Cadematori

Senior Honors Projects, 2010-2019

Research regarding the relationship between depression and bone mineral density (BMD) has produced very inconsistent and limited results, especially in younger females. The purpose of this study was to examine the relationship between depression scores and BMD in college-aged female students. Forty-six participants, ages 18-24 (+/-1.0368) completed a 24-hour dietary recall, medical history, Beck’s Depression Inventory and the Depression, Anxiety, and Stress Scale (DASS) and had their femur and sacral vertebrae BMD, z-score, and t-score measured in the Dual X-Ray Absorptiometry (DXA) machine. Participant demographics were analyzed with descriptive statistics and potential variable correlations were analyzed by partial and bipartial …

Effect Of Sulfide Toxicity On Cytochrome C Oxidase In Liver And Muscle Tissue In Fish Species, Nicole Martin

John Heinrichs Scholarly and Creative Activities Day (SACAD)

Toxic effects of sulfide have long been recognized. However, specific physiological effects have been investigated in few metabolic systems. Much of sulfide toxicity comes from inhibition of the enzyme cytochrome c oxidase (CytOx), which catalyzes the terminal step in aerobic respiration in eukaryotes. Previous work investigated CytOx activity in the presence of sulfide in numerous plant species and showed that estuarine species were more tolerant of sulfide compared to flooding sensitive species. This suggested that varying sensitivities of CytOx to sulfide exist across organisms as an adaptive mechanism to life in highly sulfidic salt marshes. But little is known whether …

Alzheimer Disease Research In The 21st Century: Past And Current Failures, New Perspectives And Funding Priorities, Francesca Pistollato, Elan L. Ohayon, Ann Lam, Gillian R. Langley, Thomas J. Novak, David Pamies, George Perry, Eugenia Trushina, Robin S.B. Williams, Alex E. Roher, Thomas Hartung, Stevan Harnad, Neal D. Barnard, Martha Clare Morris, Mei-Chun Lai, Ryan Merkley, P. Charukeshi Chandrasekera

Experimentation Collection

Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel therapeutic approaches. However, decades of such research have not effectively translated into substantial therapeutic success for human patients. Here we critically discuss these issues in order to determine how existing human-based methods can be applied to study AD pathology and develop novel therapeutics. These methods, which include patient-derived cells, computational analysis and models, together with large-scale epidemiological studies represent novel and …

Hypertonicity: Pathophysiologic Concept And Experimental Studies, Christos Argyropoulos, Helbert Rondon-Berrios, Dominic S. Raj, Deepak Malhotra, Emmanuel I. Agaba, +5 Additional Authors

Medicine Faculty Publications

Disturbances in tonicity (effective osmolarity) are the major clinical disorders affecting cell volume. Cell shrinking secondary to hypertonicity causes severe clinical manifestations and even death. Quantitative management of hypertonic disorders is based on formulas computing the volume of hypotonic fluids required to correct a given level of hypertonicity. These formulas have limitations. The major limitation of the predictive formulas is that they represent closed system calculations and have been tested in anuric animals. Consequently, the formulas do not account for ongoing fluid losses during development or treatment of the hypertonic disorders. In addition, early comparisons of serum osmolality changes predicted …

The Influence Of Prior Motor Actions On Motor Planning In Children With Autism Spectrum Disorder, Daisha Lynn Cummins

Undergraduate Honors Capstone Projects

Studies have found children with Autism Spectrum Disorder (ASD) have a rigidity of motor plans and difficulties planning and executing movements. Children with ASD also exhibit repetitive behaviors such as nail biting and rocking back and forth. When planning for movements, repetitive behaviors might manifest as difficulty in formulating new or switching between different motor plans. In typically developing individuals, actions are often influence by recently performed motor actions. We sought to determine if this influence was stronger in children with ASD.

A rotation motor task was created to evaluate the rigidity of motor planning of five children with ASD …

Viruses, Vaccines And The Public, Judy Diamond, Julia Mcquillan, Amy Spiegel, Patricia Wonch Hill, Rebecca Smith, John T. West, Charles Wood

World of Viruses

Current research in virology is changing public conceptions about vaccines and infectious disease. The University of Nebraska State Museum collaborated with research virologists, science writers, artists and learning researchers to create public outreach materials about viruses and infectious disease. The project, funded by the National Institute of Health’s SEPA program, developed comics, a book with Carl Zimmer, and other materials and programs. The project launched three kinds of learning research: 1) a survey of Nebraska adults on their opinions about vaccines and infectious disease; 2) a study comparing the mental models of viruses, vaccines and infection from virologists, teachers, and …

The Skin Disease Mutation Cx31l209f Induces A Calcium- And Cobalt-Sensitive Leak Current Across The Plasma Membrane, Husain A. Bneed

Biology Theses

Gap junctions are essential to the function of multicellular animals, which require a high degree of coordination between cells. The functions of gap junctions are highly diverse and include exchange of metabolites and electrical signals between cells, as well as functions apparently unrelated to intercellular communication. In vertebrates, gap junctions are comprised of connexin proteins and over 20 connexins have been identified in humans. Each connexin is named according to its predicted molecular weight, for instance connexin31 (Cx31) has a predicted molecular weight of 31 KDa. Mutations in connexin genes cause a variety of disorders depending on the connexin protein …

Exogenous Polyunsaturated Fatty Acid (Pufa) Scavenging Affects Phospholipid Profiles And Virulence Phenotypes In Vibrio Cholerae And Vibrio Parahaemolyticus, Anna Moravec

Honors Theses

AIM: This research had two primary objectives. First, this study sought to determine whether or not exposing Vibrio cholerae and Vibrio parahaemolyticus to polyunsaturated fatty acids (PUFAs) would lead to changes in their respective phospholipid profiles. Secondly, if membrane remodeling occurred, this study sought to determine the impact of membrane modifications on bacterial fitness by evaluating their effect on membrane permeability, biofilm formation, and response to stresses. METHODS: The Bligh and Dyer method was used to extract bacterial lipids, which were subsequently analyzed via thin-layer chromatography (TLC). The effect of fatty acids on bacterial fitness was assessed using stress, biofilm, …

The Role Of Orexin Receptors In Diurnal Variations In Learning And Memory, Jacob Christian Blotter

Undergraduate Honors Capstone Projects

The brain's ability to learn and remember is a topic of extensive debate and research. Mammals share many similarities, including the way in which information from the outside world is processed and stored. Mammalian circadian rhythms have long been thought to be essentially involved with these processes. Orexin, a neurotransmitter in the brain, plays a crucial role in arousal and circadian rhythm. This study is designed to explore the brain's ability to process and store information at different times of the circadian period, and to explore the role of orexin by comparing the performance of normal (wild-type) mice and abnormal …

Quantifying Drivers' Responses To Failures Of Semi-Autonomous Vehicle Systems, Sijun Shen

All Dissertations

The number of vehicles on the road with advanced and automated driving support systems (DSSs) is increasing. However, there may be some issues related to the implementation of DSSs in vehicles. One of those issues caused by the automated DSSs relates to the drivers' being out-of-the-loop. As drivers' roles are transitioned from system operators to systems supervisors (as in autonomous vehicles), drivers' situation awareness of the driving surroundings may decrease which could negatively affect their responses when they need to take control of the vehicle from the malfunctioned (or failed) DSSs. Additionally, with both the adaptive cruise control (ACC) and …

Issue 11

The Synapse: Intercollegiate science magazine

No abstract provided.

Effects Of Simple Postural Instructions On Running Form Modification In Recreational Runners – Preliminary Findings, Elizabeth Billington, Scott Devries, Kenshin Scoggin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background and purpose: Running is one of the most popular exercises but it is also an activity with a high incidence of injury. Running form modification involving a forward lean of the trunk and forefoot strike pattern has been shown to be effective in attenuating the impact forces of the lower extremity. However, it is currently unknown how these changes can be most effectively instructed and learned by the runners. Previous studies have shown that practicing a motor task with an external focus can facilitate learning and retention when compared to the more common internal focus instructions. The purpose of …

Impact Of Epigallocatechin-3-Gallate (Egcg), A Broad-Spectrum Anti-Inflammatory, In Controlling Intestinal Factors Contributing To Inflammatory Bowel Disease., Gerald Wayne Dryden, Jr.

Electronic Theses and Dissertations

This dissertation explores the role of epigallocatechin-3-gallate (EGCG), as a potential treatment for patients with inflammatory bowel disease (IBD). IBD is a common disorder that causes a great deal of suffering. Our understanding of the etiologies, pathogenic mechanisms, and treatment targets continues to evolve. Many new therapeutic targets are making their way through the pharmaceutical pipelines. However, not all patients benefit from these therapies. EGCG has long been studied as an anti-cancer agent. Most of our understanding of this compound comes from the oncologic literature. As the pathways of oncology and inflammation converge, new lessons can be taken from the …

Spaces Of Visibility And Identity, Shelby R. Purdy

Undergraduate Honors Theses

“Spaces of Visibility and Identity” is an exploration on how being immersed in constant visibility has an effect on an individual’s identity. Visibility is not a narrow term meant to signify solely observation; rather, visibility is the state of existing within a world that does not allow for total isolation. To exist within the world is to be visible to others, and this visibility is inescapable. Visibility can be seen as a presentation or a disclosure of oneself to other beings. Existing within the world inevitably implies that one is presenting oneself to others, whether or not the presentation is …

Cooling Effectiveness Of Modified Cold-Water Immersion Method Following Exercise-Induced Hyperthermia, Katherine Elizabeth Luhring

Graduate Theses and Dissertations

Context: Recommended treatment of exertional heat stroke (EHS) includes whole body cold-water immersion (CWI); however, remote locations, spatial or monetary restrictions challenge CWI feasibility. Thus, the development of a modified, portable CWI method would allow for optimal treatment of EHS when restrictions apply. Objective: Determine cooling efficacy of modified CWI (tarp assisted cooling with oscillation; TACO) following exertional hyperthermia. Design: Randomized, crossover controlled trial. Setting: Environmental chamber (33.4 ± 0.8°C, 55.7 ± 1.9% relative humidity). Patients or Other Participants: Sixteen (9 males, 7 females) volunteers (26 ± 4.7y, 1.76 ± 0.09m, 72.5 ± 9.0kg, 20.7 ± 7.1%body fat) with no …

The Influences Of Texture And Mastication Pattern On Flavor Perception Across The Lifespan, Curtis Robert Luckett

Graduate Theses and Dissertations

Texture is an often-overlooked food attribute and is known to influence other food characteristics. More specifically, texture has been repeatedly to influence how we perceive flavor. Several studies have linked this change in flavor perception to the altered mastication patterns that accompany texture changes. This dissertation is composed of four studies that were designed to address how American food consumers view texture and other food attributes as well as characterize how texture and mastication can influence temporal flavor dynamics. The first study was a survey that outlined consumer attitudes towards a variety of different foods. This study solidified that texture …

Effect Of Sulfide Toxicity On Cytochrome C Oxidase In Liver And Muscle Tissue In Fish Species, Nicole Martin

SACAD: Scholarly Activities

Toxic effects of sulfide have long been recognized. However, specific physiological effects have been investigated in few metabolic systems. Much of sulfide toxicity comes from inhibition of the enzyme cytochrome c oxidase (CytOx), which catalyzes the terminal step in aerobic respiration in eukaryotes. Previous work investigated CytOx activity in the presence of sulfide in numerous plant species and showed that estuarine species were more tolerant of sulfide compared to flooding sensitive species. This suggested that varying sensitivities of CytOx to sulfide exist across organisms as an adaptive mechanism to life in highly sulfidic salt marshes. But little is known whether …

Who Is A Student: Completion In Coursera Courses At Duke University, Molly Goldwasser, Chris Mankoff, Kim Manturuk, Lorrie Schmid, Keith E. Whitfield

Current Issues in Emerging eLearning

Much of the interest in MOOCs centers on questions about who completes them. Duke’s Coursera-based Massive Open Online Courses (MOOCs) confirm many demographic trends previously delineated by researchers at peer institutions. As found in previous research, this study found individuals who speak English as a first language and who already earned at least a bachelor’s degree are the most likely to complete a Coursera course. MOOC researchers to date have not, however, developed clear operational definitions about who constitutes a learner at the outset of the course. This paper proposes some possible definitions to standardize future research. Further, this study …

1st Place Contest Entry: The Effectiveness Of Yoga Therapy On An Adult, Post-Stroke Population: A Systematic Review, Baylor E. Hogan

Kevin and Tam Ross Undergraduate Research Prize

This is Baylor Hogan's submission for the 2016 Kevin and Tam Ross Undergraduate Research Prize, which won first place. She wrote about the effects of yoga therapy on the physical and mental wellbeing of stroke patients. You can read the final essay that came out of her research here.

Baylor is a senior at Chapman University, majoring in Kinesiology. Her faculty mentor is Dr. Elizabeth DeBaets.

Final Progress Report California Open Educational Resources Council, Katherine Harris

Faculty Research, Scholarly, and Creative Activity

Submitted to the Intersegmental Committee of Academic Senates December 1, 2015 (rev 4/15/16) Permalink: http://tinyurl.com/FPRCAOERC41516 Printable PDF Version: http://tinyurl.com/FPRCAOERC41516pdf See also CA-OERC White Paper: OER Adoption in College Classrooms

Discourses Of Madness And Me: Critical Examinations Of Western Discourses Of Madness And Psychiatry, Erin E. Casey

Showcase of Graduate Student Scholarship and Creative Activities

This paper is a critical examination of western medical paradigms alongside histories of psychiatry that argues for a culturally situated approach to mental health advocacy that maintains the importance of the physiological foundations of traditional biomedical approaches to disease. In doing so, I examine the discourses of madness, and society’s attempts to control and “fix” what is deemed “mad” through a historical lens. My position and critique utilizes a reflexive narrative process embracing my identities both as a consumer of mental health services and as an advocate for those with mental illnesses.

April 14, 2016, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Engineering And Commercialization Of Human-Device Interfaces, From Bone To Brain, Jeffrey R. Capadona

Faculty Scholarship

Cutting edge developments in engineering of tissues, implants and devices allow for guidance and control of specific physiological structure-function relationships. Yet the engineering of functionally appropriate human-device interfaces represents an intractable challenge in the field. This leading opinion review outlines a set of current approaches as well as hurdles to design of interfaces that modulate transfer of information, i.a. forces, electrical potentials, chemical gradients and haptotactic paths, between endogenous and engineered body parts or tissues. The compendium is designed to bridge across currently separated disciplines by highlighting specific commonalities between seemingly disparate systems, e.g. musculoskeletal and nervous systems. We focus …

The Patents In Space Act: Jedi Mind Trick Or Real Protection For American Inventors On The International Space Station?, Jocelyn H. Shoemaker

Journal of Intellectual Property Law

No abstract provided.

Cwu Faculty Senate Minutes - 04/06/16, Janet Shields

Faculty Senate Minutes

These are the official Central Washington University Faculty Senate minutes for the April 6, 2016 regular meeting.

Lin28/Let-7 Axis As A Regulator Of Myocardial Ischemic Injury, Shaurya Joshi

Open Access Dissertations

One of the prominent causes of heart failure is atherosclerosis of the coronary arteries. Obstruction of blood flow within the coronary arteries results in inadequate perfusion, or ischemia, of the heart muscle. The let-7 family of microRNAs (miRs) regulates critical cell functions, including survival signaling, metabolic control and glucose utilization, which may be important during myocardial ischemia. MiR-let-7 expression is under tight temporal and spatial control through multiple redundant mechanisms. The mechanisms and functional consequences of miR-let-7 regulation in ischemic myocardium largely remain unknown. Here we show that miR-let-7c, -7a and -7g are downregulated in the adult mouse heart early …

Hospital Admissions Due To Diseases Of Arteries And Veins Peaked At Physiological Equivalent Temperature −10 To 10 °C In Germany In 2009–2011, Ivy Shiue, David R. Perkins, Nick Bearman

College of Natural and Applied Sciences

We aimed to understand relationships of the weather as biometeorological and hospital admissions due to diseases of arteries and veins by subtypes, which have been scarcely studied, in a national setting in recent years. This is an ecological study. Ten percent of daily hospital admissions from the included hospitals (n = 1,618) across Germany that were available between 1 January 2009 and 31 December 2011 (n = 5,235,600) were extracted from Statistisches Bundesamt, Germany. We identified I70-I79 Diseases of arteries, arterioles and capillaries and I80-I89 Diseases of veins, lymphatic vessels and lymph nodes by International Classification of Diseases version 10 …

Relationships Of Physiologically Equivalent Temperature And Hospital Admissions Due To I30–I51 Other Forms Of Heart Disease In Germany In 2009–2011, Ivy Shiue, David R. Perkins, Nick Bearman

College of Natural and Applied Sciences

We aimed to understand relationships of the weather as biometeorological and hospital admissions due to other forms of heart disease by subtypes, which have been paid less attention, in a national setting in recent years. This is an ecological study. Ten percent of daily hospital admissions of the included hospitals (n = 1618) across Germany that were available between 1 January 2009 and 31 December 2011 (n = 5,235,600) were extracted from Statistisches Bundesamt, Germany. We identified I30–I51 other forms of heart disease by the International Classification of Diseases version 10 as the study outcomes. Daily weather data from 64 …

Analysis Of Arm Movement Prediction By Using The Electroencephalography Signal, Reza Darmakusuma, Ary Setijadi Prihatmanto, Adi Indrayanto, Tati Latifah Mengko, Lidwina Ayu Andarini, Achmad Furqon Idrus

Makara Journal of Technology

Various technological approaches have been developed in order to help those people who are unfortunate enough to be afflicted with different types of paralysis which limit them in performing their daily life activities independently. One of the proposed technologies is the Brain-Computer Interface (BCI). The BCI system uses electroencephalography (EEG) which is generated by the subject’s mental activity as input, and converts it into commands. Some previous experiments have shown the capability of the BCI system to predict the movement intention before the actual movement is onset. Thus research has predicted the movement by discriminating between data in the “rest” …