Digital Commons Network^™

Modeling Reveals The Dependence Of Hippocampal Neurogenesis Radiosensitivity On Age And Strain Of Rats, Eliedonna Cacao, Sidath Kapukotuwa, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus. Various species and strains of rodent models have been used to study radiation-induced changes in neurogenesis and these investigations have utilized only a limited number of doses, dose-fractions, age and time after exposures conditions. In this paper, we have extended our previous mathematical model of radiation-induced hippocampal neurogenesis impairment of C57BL/6 mice to delineate the time, age, and dose dependent alterations in neurogenesis of a diverse strain of rats. To the best of our knowledge, …

Like A Jar Of Flies? A Study Of Self-Control In An Organizational Social Dilemma With Large Stakes, Matthew W. Mccarter, Jonathan R. Clark, Darcy Fudge Kamal, Abel Winn

Business Faculty Articles and Research

We study the practice of self-control in an organizational social dilemma when the stakes are large, using 47 years of vital census data from 18^th century Sweden. From 1750 to 1800, eighty percent of Sweden lived in a simple-structure organization called a bytvång or village commons. The amount of resources a village family received was a function of their size. During this period, crop failures left the population facing starvation. Using autoregressive time-series modeling, we test whether the people of Sweden continued to take steps toward increasing the stress on the commons by marrying and birthing children or practiced …

Modeling Of Cantú Syndrome In Zebrafish, Soma Sekhara Singareddy

McKelvey School of Engineering Graduate Student Theses & Dissertations

Although rare, Cantú syndrome (CS) is a debilitating syndrome without any specific therapy, caused by gain-of-function (GOF) mutations in KCNJ8 and ABCC9 genes that encode ATP-sensitive potassium (KATP) channels. To better understand the link between molecular dysfunction and the complex pathophysiology, animal models that can rigorously mirror human CS are essential. Using ABCC9-mutated zebrafish, which can provide significant advantages over mice as an appropriate vertebrate model, GOF has been demonstrated at a cellular level in the ventricular cardiomyocytes. This also marks the first-known characterization of KATP currents in teleost hearts. In addition, sulfonylurea sensitivities of the channels have been …

Making Space For Makerspace: How Adding A Makerspace Can Benefit Art Museum Education Programming, Kaeleigh Thorp

Master's Projects and Capstones

In this capstone project, I advocate for adding makerspaces to art museum education programming. I review the foundational educational concepts of a makerspace which help explain why it is a modern strategy to increasing visitor learning. This includes John Dewey’s theories of experience and education, Howard Gardner’s multiple intelligences theory, George Hein’s studies of museum visitor behavior, and the physiological science of learning. I then propose four key terms essential for visitor learning, and explain how makerspaces successfully incorporate them. The four key terms are: 1. multiple intelligences, 2. direct experience, 3. inquiry based and open ended learning, and 4. …

Debunking The Self: Jastrow, Münsterberg And The Automatograph, He Drayson

School of Art, Design and Architecture

No abstract provided.

Dhikr (Recitation) And Relaxation Improve Stress Perception And Reduce Blood Cortisol Level In Type 2 Diabetes Mellitus Patients With Oad, Faisal Amir, Gondo Mastutik, M Hasinuddin, Suhartono Taat Putra

Folia Medica Indonesiana

Recitation and relaxation are translated as stimuli that can turn disstraints into uneven conditions (balanced conditions). The purpose of this study was to explain the effect of remembrance and relaxation on improving stress perception and decreasing blood cortisol levels in patients with type 2 diabetes mellitus with Anti Diabetes Medication (OAD). This type of research is quasi-experimental with the non randomized control group pretest posttest design. The population in this study were all type 2 diabetes mellitus patients at the Internal Poly department of Syarifah Ambami Hospital Rato Ebu Bangkalan. The study sample was divided into 2 groups, namely control …

A Low-Intensity, Hybrid Design Between A "Traditional" And A "Course-Based" Research Experience Yields Positive Outcomes For Science Undergraduate Freshmen And Shows Potential For Large-Scale Application, Thushani Rodrigo-Peiris, Lin Xiang, Vincent M. Cassone

Biology Faculty Publications

Based on positive student outcomes, providing research experiences from early undergraduate years is recommended for science, technology, engineering, and mathematics (STEM) majors. To this end, we designed a novel research experience called the “STEMCats Research Experience” (SRE) for a cohort of 119 second-semester freshmen with diverse college preparatory levels, demographics, and academic majors. The SRE targeted student outcomes of enhancing retention in STEM majors, STEM competency development, and STEM academic performance. It was designed as a hybrid of features from apprenticeship-based traditional undergraduate research experience and course-based undergraduate research experience designs, considering five factors: 1) an authentic research experience, 2) …

An Investigation Of Enzymes Capable Of Activating Cannabinoid Prodrugs, Brittney J. Morgan

Master's Theses

The plant Cannabis sativa contains a class of terpenophenols called cannabinoids which, in their active form, have been shown to have antiproliferative, anti-metastatic, anti-angiogenic, and pro-apoptotic effects on several types of cancer cells both in vitro and in vivo. Cannabinoids have been shown to not exert this apoptotic activity in healthy cells and they do not elicit the usual side effects seen with conventional chemotherapies. However, naturally occurring prodrugs from Cannabis must first be converted into the active form to induce the apoptotic and other physiological activities. Although humans do not possess the enzyme(s) necessary for this conversion, several different …

Blended With The Savior: Gregory Of Nyssa's Eucharistic Pharmacology In The Catechetical Oration, John David Penniman

Faculty Journal Articles

Humankind, for Gregory of Nyssa, was poisoned through a primordial act of eating the forbidden fruit from the Garden of Eden. As a result, the toxin of sin and death has been blended into the body and soul of each person, dispersing itself throughout the component parts of their nature. If eating and drinking initiated the spiritual and physical degradation of humanity, Gregory argues, then it must also be through eating and drinking—namely, through the Eucharist—that humanity will be healed. This article proposes that Gregory's instruction on the Eucharist in his Catechetical Oration should be understood as more than merely …

Development Of A Methodology For Predicting Consumer Acceptance And Preference Toward Beverages, Shilpa Shailesh Samant

Graduate Theses and Dissertations

Consumer behavior toward food/beverages is influenced by multisensory attribute perceptions as well as emotional experiences. Traditional methods of sensory testing lack the ability to capture emotional responses and as a result, measuring food/beverage-evoked emotions remains a research challenge. There were three objectives of this dissertation study. Firstly, this study aimed to develop prediction models of acceptance of and preference for basic taste solutions using sensory attribute intensities and emotional responses. Secondly, this study aimed to extend the findings of the first objective to develop prediction models of commercially-available vegetable juice products in terms of (a) acceptance and preference under blind-tasting …

Internal Deformation Measurements And Optimization Of Synthetic Vocal Fold Models, Cassandra Jeanne Taylor

Theses and Dissertations

Developing lifelike vocal fold models is challenging due to various associatedbiomechanical complexities. Nevertheless, the development and analysis of improved vocal foldmodels is worthwhile since they are valuable tools for gaining insight into human vocal foldvibratory, aerodynamic, and acoustic response characteristics. This thesis seeks to contribute tothe development of computational and physical vocal fold modeling in two ways. First is byintroducing a method of obtaining internal deformation fields within vibrating synthetic vocal foldmodels; second is by presenting an optimization algorithm coupled with a computational vocalfold model to optimize geometry and stiffness of a synthetic vocal fold model to achieve morerealistic vibration …

Christian Theistic Anthropology, Anthony T. Vento

Doctoral Dissertations and Projects

At the present moment, which is prior to conducting any research, I am of the opinion that anthropology has been influenced by certain schools of thought, and each school’s definition establishes a trajectory which definitively determines the adherent’s worldview. The schools of anthropology which are prevalent in today’s world, in my estimation, are the evolutionist’s perspective, the hedonistic perspective, the rationalistic perspective, the dualistic perspective and the Christian perspective. I will seek to objectively and unbiasedly define each perspective’s understanding of man, then I will compare and contrast the main tenets of each school of thought, and finally, I will …

Multidimensionality: Rethinking Power Projection For The 21st Century, David J. Katz

The US Army War College Quarterly: Parameters

No abstract provided.

Co-Infection Of Zika And Dengue Virus In Aedes Aegypti And Aedes Albopictus Mosquitoes, Felicia Vazquez

Theses and Dissertations

The term co-infection describes an event when multiple pathogens infect a single host. For vector-borne diseases, a vector may become co-infected by feeding either on a single host that has multiple pathogens or feeding multiple hosts, each of which may be infected. Co-infection in non-vector hosts has been shown to influence immune response and eventual outcome of disease, and is likely to have a similar impact on vector species. With multiple vector-borne diseases circulating in South Texas, the potential for co-infection exists. We examined when mosquitoes are infected with one virus and subsequently infected with another. We hypothesized that the …

The Influence Of Time Spent In Beginning And End-State Postures On Grasp Choice, Rachel Modersitzki

Undergraduate Honors Capstone Projects

The choice to end comfortably often requires adoption of uncomfortable beginning states, demonstrating that a sequence of movement is planned in advance of movement onset. Many factors may influence the choice of comfortable end-state postures including the greater precision and speed afforded by postures at joint angle mid-ranges (Short & Cauraugh, 1999). There has been no evaluation of the hypothesis that postures are chosen based on minimizing time spent in postures. Typically, the time spent in beginning and end-states are not explicitly constrained, but the end-state posture is likely held for the longer amount of time due to greater precision …

Effects Of Exercise On Clinical Couple Interactions, Samantha Karma-Jean Simpson

Theses and Dissertations

Research has shown that exercise has the potential to improve couple relationships. This study contributes to current literature by examining the associations between exercise, its duration, and its intensity and daily clinical couple interactions. Participants were 22 married couples in a treatment-as-usual setting who completed daily diaries about daily behaviors and marital interactions. Multilevel models were run, and results showed that wives who exercised were more likely to report a negative interaction with their husband that day. When wives exercised longer, both they and their husbands were more likely to report positive interactions that day. Interestingly, if husbands exercised longer …

Triggers, Protectors, And Predictors In Episodic Migraine., Michael J. Marmura

Department of Neurology Faculty Papers

PURPOSE OF REVIEW: A wide variety of triggers prompt attacks in episodic migraine. Although experimental triggers such as glyceryl trinitrate reliably produce migraine, natural triggers are much less predictable and vary in importance between individuals. This review describes the most common triggers in episodic migraine and provides strategies for managing them in clinical practice.

RECENT FINDINGS: Multiple migraine attack triggers have been established based on patient surveys, diary studies, and clinical trials. Stress, menstrual cycle changes, weather changes, sleep disturbances, alcohol, and other foods are among the most common factors mentioned. Clinical studies have verified that fasting, premenstrual periods in …

Concentrations Of Purine Metabolites Are Elevated In Human Fluids From Adults And Infants And In Livers From Mice Fed Diets Depleted Of Bovine Milk Exosomes And Their Rna Cargos, Ana Aguilar Lozano

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Since miRNAs discovery, evidence keeps accumulating on their role in human physiology for homeostasis and implications during disease development. Upon the discovery that miRNAs could be encapsulated in exosomes and provide protection, evidence keeps accumulating on the possibility for miRNAs to be transferred between distant cells and elicit gene expression changes, and clinical trials are being developed to identify miRNAs in body fluids that could predict disease outcomes based on miRNA encapsulation in exosomes making them stable in body fluids. Recently, studies have shown that dietary miRNAs encapsulated in exosomes can be absorbed in mice and humans, and on the …

Progress Of Synthetic Biology Research In Medical Applications, Cui Jinming, Wang Liwei, Chang Zhiguang, Zang Zhongsheng, Liu Chenli

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the field of medical applications, synthetic biology researchers design genetic circuits to modify human cells, or to modify synthetic organisms such as bacteria and viruses and make them interact with the human body. These artificially designed organisms are capable of perceiving disease-specific signals or artificial signals, targeting abnormal cells and foci, expressing reporter molecules or releasing therapeutic drugs, thus enabling the monitoring of human physiological conditions and the diagnosis and treatment of typical diseases such as tumors, metabolic diseases, and drug-resistant bacteria infections. This article will comprehensively describe some recent research progress.

A Human-Environment Systems Approach To Outdoor Recreation, Human Biological Stress, And Landscape Aesthetics, Ellie Opdahl, Kathryn Demps, Julie Heath

MILES Data Sets

Outdoor recreation, as the intersection between physical exercise and nature, provides a multitude of psychological and physiological benefits to human well-being. Though many studies have reported qualitative stress reduction from outdoor recreation, few have focused on quantitative measurements of stress across recreational activity types, intrapersonal differences, and environmental variables. To determine whether outdoor recreation affects physiology, we collected 190 paired salivary cortisol and testosterone samples and 157 surveys from 88 hikers, 81 mountain bikers, and 44 off-highway vehicle (OHV) motorists. After recreation, cortisol concentrations were significantly reduced in hikers and OHV motorists, but cortisol and testosterone concentrations increased in mountain …

Impact Of Biobanks On Research Outcomes In Rare Diseases: A Systematic Review, Monique Garcia, Jenny Downs, Alyce Russell, Wei Wang

Research outputs 2014 to 2021

BACKGROUND: Alleviating the burden of rare diseases requires research into new diagnostic and therapeutic strategies. We undertook a systematic review to identify and compare the impact of stand-alone registries, registries with biobanks, and rare disease biobanks on research outcomes in rare diseases.

METHODS: A systematic review and meta-aggregation was conducted using the preferred reporting items for systematic reviews and meta-analyses (the PRISMA statement). English language publications were sourced from PubMed, Medline, Scopus, and Web of Science. Original research papers that reported clinical, epidemiological, basic or translational research findings derived from data contained in stand-alone registries, registries with biobanks, …

The Echo: November 9, 2018, Taylor University

2018-2019 (Volume 106)

New diversity position created – Taylor joins Colleges Against Cancer – Alumnus receives teaching fellowship – Lesner speaks on nonprofits – Trevor Osswald’s photos of the week – Bree’s Beat International News – Correction – Ivy and a son named Levi – Student hold each other’s stories – ‘Prevention is really our best medicine – croc thoughts – The Weekly Bachelor and Bachelorette – Humans of Taylor U – Weekly Crossword – Sudoku -- #TaylorU’s Top Tweets – Learn the art of looking through the eyes of another – Stories walk ‘Into the Woods’ and onto the stage – Discover …

Writing To Learn: Embedding A Crucial Study Skill In A Gateway Science Course, Shylaja Akkaraju

Publications and Research

Handwriting is a multisensory process known to enhance memory, focus, engagement, and cognition in the learner, thereby making it a valuable study skill. In an attempt to embed handwriting as a study skill in a gateway science course, I used a combination of scaffolding and individual student consultations. Scaffolding emphasized the use of desirable difficulties and retrieval practice through the implementation of techniques such as the flipped learning approach and take home-in class hybrid essay exams. While the former helped to increase overall student success the latter technique was aimed at enhancing written fluency in the subject, curbing procrastination, and …

Natural Cycle Versus Hormone Replacement Therapy Cycle In Frozen-Thawed Embryo Transfer, Ziya Kalem, Müberra Namlı Kalem, Batuhan Bakirarar, Erkin Kent, Timur Gurgan

Saudi Medical Journal

Objectives: To compare implantation rates, clinical pregnancy rates and live birth rates associated with natural and hormone replacement therapy (HRT) methods of endometrial preparation in frozen-thawed embryo transfer (FET) cycles. Methods: The results of 108 natural cycles and 224 HRT cycles of FET transfers performed in a private in vitro fertilization (IVF) center between June 2013 and August 2015 were retrospectively compared with respect to implantation rate, clinical pregnancy rate, and live birth rate. Results: A total of 144 embryos were transferred in 108 natural cycles and 357 embryos were transferred in 224 HRT cycles. No statistically significant differences were …

Development, Characterization And Application Of Multi-Detector Flow Injection Systems Based On A Serial Flow Configuration For Simultaneous Multianalyte Determination, Aisha Rashed Al Hameidi Yammahi

Chemistry Theses

Oxidase enzymes have been used successfully in the analysis of several biochemical species such as glucose, lactate, pyruvate, creatine, creatinine, amino acids, cholesterol and sialic acid, by generating - in a single or consecutive reaction -hydrogen peroxide (H₂O₂) as a signal molecule which is commonly detected amperometrically. Some approaches have been also reported to use more than one enzyme in a given system to achieve multi-analyte determination. This study aims to evaluate a novel approach for n-analyte determination based on n-enzyme reactors (each is loaded with one or more oxidase enzyme) as well as n-1 catalase immobilized …

Application Of Quality Of Experience In Networked Services: Review, Trend & Perspectives, Asif Ali Laghari, Hui He, Muhammad Shafiq, Asiya Khan

School of Engineering, Computing and Mathematics

No abstract provided.

Living Inside The Box: Environmental Effects On Mouse Models Of Human Disease., John P Sundberg, Paul N Schofield

Faculty Research 2018

The impact of the laboratory environment on animal models of human disease, particularly the mouse, has recently come under intense scrutiny regarding both the reproducibility of such environments and their ability to accurately recapitulate elements of human environmental conditions. One common objection to the use of mice in highly controlled facilities is that humans live in much more diverse and stressful environments, which affects the expression and characteristics of disease phenotypes. In this Special Article, we review some of the known effects of the laboratory environment on mouse phenotypes and compare them with environmental effects on humans that modify phenotypes …

Niccolo Leo Caldararo, Big Brains And The Human Superorganism: Why Special Brains Appear In Hominids And Other Social Animals. Rowman & Littlefield, 2017, Andrew Targowski

Comparative Civilizations Review

No abstract provided.

Paper Promises For Drug Innovation, Erika Lietzan

Faculty Publications

Innovation does not stop when a new medicine is launched. Development of new uses for already approved drugs, in particular, can make profound contributions to the public health. Whether a new use is suspected during the initial premarket trials, identified through focused research after approval, or discovered serendipitously by physicians treating patients, however, it requires extensive clinical testing before it can be approved by FDA. This testing takes time and money — three to five years on average, and as much as $300 million. This Article considers the incentives that federal law offers to companies to make this investment: patent …

Harald Von Beckh, Pioneer Of Microgravity Medical Research, Pablo De Leon

Space Studies Faculty Publications

Harald Von Beckh was born in Vienna, Austria, on November 17, 1917. He graduated as a Doctor of Medicine from the Vienna University Faculty of Medicine in 1940. He began working at the Academy of Aviation Medicine in Berlin where he helped in the development of the concept of the Keplerian trajectory to obtain periods of microgravity while collaborating with Dr. Heinz von Diringshofen. In 1941 he was appointed as a faculty member at the Academy of Medicine of the Luftwaffe.

At the end of the war, without any possibility to continue his research in Germany, Von Beckh made contacts …