Digital Commons Network^™

The Impact Of Integrating Oral Health Education Into A Human Physiology Curriculum For Students Of Early Childhood Education, Ming-Chung Lee, Ling-Hsia Wang, Tzu-Chiang Lin, Yung-Ta Chang, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

Abstract Background/purpose The good oral health plays a pivotal role in improving the general health of the body. The purpose of this study was to evaluate an innovative design incorporating oral health education into a human physiology curriculum for students of early childhood education by evaluating the students’ perspectives on the oral health curriculum. Materials and methods Forty-two first-year students who took the compulsory course entitled “Introduction to Human Physiology” in National Taiwan Normal University in 2022 were invited to fill out the questionnaire for a presurvey regarding their familiarity with basic oral health concepts, and a postsurvey in which …

Systematic Profiling Of Dnmt3a Variants Reveals Protein Instability Mediated By The Dcaf8 E3 Ubiquitin Ligase Adaptor, Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikołaj Słabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter J M Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell

Faculty, Staff and Students Publications

Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants occur across the gene with some particularly associated with malignancy, but the functional relevance and mechanisms of pathogenesis of the majority of mutations are unknown. Here, we systematically investigated the methyltransferase activity and protein stability of 253 disease-associated DNMT3A mutations, and found that 74% were loss-of-function mutations. Half of these variants exhibited reduced protein stability and, as a class, correlated with greater clonal expansion and acute …

Steroid Receptor Coactivators – Their Role In Immunity, Yosi Gilad, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Steroid Receptor Coactivators (SRCs) are essential regulators of transcription with a wide range of impact on human physiology and pathology. In immunology, SRCs play multiple roles; they are involved in the regulation of nuclear factor-κB (NF-κB), macrophage (MΦ) activity, lymphoid cells proliferation, development and function, to name just a few. The three SRC family members, SRC-1, SRC-2 and SRC-3, can exert their immunological function either in an independent manner or act in synergy with each other. In certain biological contexts, one SRC family member can compensate for lack of activity of another member, while in other cases one SRC can …

Child Dietary Patterns In Homo Sapiens Evolution: A Systematic Review, Lora L Iannotti, Emmanuel A Gyimah, Miranda Reid, Melissa Chapnick, Mary Kate Cartmill, Chessa K Lutter, Charles Hilton, Theresa E Gildner, Elizabeth A Quinn

2020-Current year OA Pubs

Dietary patterns spanning millennia could inform contemporary public health nutrition. Children are largely absent from evidence describing diets throughout human evolution, despite prevalent malnutrition today signaling a potential genome-environment divergence. This systematic review aimed to identify dietary patterns of children ages 6 months to 10 years consumed before the widespread adoption of agriculture. Metrics of mention frequency (counts of food types reported) and food groups (globally standardized categories) were applied to: compare diets across subsistence modes [gatherer-hunter-fisher (GHF), early agriculture (EA) groups]; examine diet quality and diversity; and characterize differences by life course phase and environmental context defined using Köppen-Geiger …

Teaching Applied Exercise Physiology Using A Prototype Energy Expenditure Measurement Device, James W. Navalta, Dustin W. Davis, Bryson Carrier, Jacquelyn V.L Sertic, Peyton Cater

Kinesiology and Nutrition Sciences Faculty Research

Undergraduate and graduate students in courses designed to introduce research techniques in exercise physiology were provided the novel opportunity through Project-based Learning (PBL) to utilize a prototype device to measure energy expenditure (EE). This report summarizes how EE measurements were incorporated via PBL into course-required experiments and determined perceived understanding of exercise and metabolism. Undergraduate experiments included measurement of EE following high intensity cycling preceded by a motivating yell, and EE after upper-body and lower-body exercise performed at simulated altitude. Graduate experiments included evaluation of the EE cost of skipping, and EE during longboard skateboarding. Undergraduate students perceived greater increases …

Spaceflight And Differential Gene Expression Analysis Of Mice Quadriceps Exposed To Microgravity, Tommy Nguyen

Master's Projects

he trip to Mars and back is planned for the next 20 years. Improvement in technology and research has allowed data analysis, at a larger scale, on spaceflight specimen. However, research involving spaceflight is decentralized, as research is spread across laboratories with different methodologies. NASA’S GeneLab is a public repository for spaceflight-related omics data and promotes centralizing spaceflight RNA-Seq studies using NASA’s RNA-Seq pipeline. Jonathan Oribello, a SJSU’s Bioinformatics graduate and now an employee at GeneLab, has implemented Nextflow to NASA’s RNA-Seq pipeline. The Nextflow RNA-Seq pipeline was ran on San Jose State University’s College of Science High Performance Computing …

An Examination Of Bone Loss During Space Travel With Differential Gene Expression Analysis, Claudia Vo

Master's Projects

Spaceflight poses many risks to human health due to the harsh conditions of microgravity, cosmic radiation, and confinement. One of the impacts that spaceflight entails is bone loss, which is a risk to astronauts as future space missions will require long travel durations. To elucidate the role of genetics in spaceflight bone loss, in this study differential gene expression analysis was performed using Nextflow-RCP, an adaptation of NASA Genelab’s RNA-Seq Consensus pipeline. The dataset for this project was GLDS-241, which contained samples from mice femoral skin. To gain a comprehensive understanding of the genes involved in bone loss, the results …

Noise And Time Pressure Effects On Situation Awareness And Aviation Maintenance Tasks, Syaza R. M. Haris

Doctoral Dissertations and Master's Theses

Aircraft maintenance technicians (AMTs) working in a line maintenance work setting are very susceptible to the deafening occupational noise from the airport vicinity or the maintenance machinery itself. Compared to a base maintenance working period, a line maintenance job requires AMTs to complete a task within a short time frame. The current study's objective is to determine if different noise levels and time pressure influence AMTs' performance and situation awareness (SA). Sixteen Embry-Riddle Aeronautical University students majoring in Aviation Maintenance Science participated in a within-subject experimental design. Each participant's performance, SA level, and perceived workload were measured during maintenance tasks …

The Role Of Neuronal Atp-Sensitive Potassium Channels In Learning And Memory, Shaul Vladimir Yahil

Arts & Sciences Graduate Student Theses and Dissertations

ATP-sensitive potassium (KATP) channels link cellular metabolism and membrane excitability in many tissues, including brain and pancreas. Gain-of-function (GOF) mutations to KATP channels cause neonatal diabetes, with some patients exhibiting developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. Diabetic symptoms have been attributed to loss of membrane excitability and insulin secretion in pancreatic β-cells, though the origin of neurological deficits and the effects of neuronal KATP-GOF mutations more generally remain elusive. In this dissertation, I will present evidence that mice expressing KATP-GOF mutations pan-neuronally (nKATP-GOF) demonstrated sensorimotor and cognitive deficits, whereas hippocampus-specific hKATP-GOF mice exhibited predominantly learning and memory deficits. …

Microfluidic-Coupled In Vitro Model Of The Blood-Brain Barrier, Subhra Mohapatra, Shyam S. Mohapatra, Tao Wang, Taylor Martinez

USF Patents

An in vitro microfluidic device includes a device configured to model a blood-brain barrier. The device includes a center well in fluidic communication with each of an inlet and an outlet. Each of the center well, inlet, and outlet includes a porous membrane that separates a “blood” portion (a fluid flow portion) from a “brain” portion (a fluid containing portion). The porous membrane is seeded with endothelial cells such as the human venule endothelial cells (HUVECs) on the blood side, and with astrocytes on the brain side, to accurately model the blood-brain barrier. Fluid flows between the inlet, the center …

Pranayama Breathing Detection With Deep Learning, Bikash Shrestha

Theses

Yoga, a complementary health approach, according to a 2017 National Health Interview Survey by the Center for Disease Control and Prevention (CDC), is a choice of around 14.3% adults in the US. Kapalbhati pranayama, a yoga practice of alternating fast exhales and longer passive inhales, is understood to improve our health. Incorrect and irregular practices, however, can cause injuries and adverse effects. To avoid these undesired effects, it is essential to maintain a pace fit for the practitioner. In the absence of any tools to observe a pace of practice, this work develops a deep learning method that listens to …

An Investigation Into The Use Of An Herbal Labor Induction Tincture Containing Black Cohosh, Cramp Bark, Partridgeberry, And Motherwort On Contractile Responses Produced From Isolated Strips Of Mouse Uterine Tissues, Clayton Neuenschwander, Katrina Wu, Teresa F. Degolier

Biological Sciences Faculty Publications

Introduction: Alternative solutions in the form of herbal remedies meant to ease or expedite the process of labor have often been pursued and administered but have seldom been quantitatively tested for efficacy. Published research has shown some validation for some commonly used herbs such as blue cohosh (Caulophyllum thalictroides), red raspberry (Rubus idaeus), castor bean (Ricinus communis) and evening primrose (Oenothera biennis) on isolated mouse uterine strips. Methods: This study tested an array of herbs used by midwives in a labor induction tincture, which included black cohosh (Actaea racemosa), cramp bark (Viburnum opulus), partridgeberry (Mitchella repens), and motherwort (Leonurus cardiaca). …

Best Practice Guideline: Color-Coded Syringe Labeling Of Anesthesia Induction Drugs, Lauren Elizabeth Pilgrim, Ashley Taylor Johnson

Doctoral Projects

The purpose of this Doctor of Nursing Practice (DNP) project was to propose a safe practice recommendation through the utilization of evidence-based research on the use of the standardized color-coded labeling guidelines for user-filled syringes in anesthesia practice. The primary objective of standardized color-coded labeling is to improve patient safety by facilitating the identification of user-prepared medication syringes. Guidelines developed by the American Society for Testing and Materials International (ASTM) are endorsed by the American Society of Anesthesiologists (ASA) and aim to increase quality care and patient safety. Currently, there is no standardized color-coded labeling system in anesthesia practice that …

Exploring Thermal State In Mixed Immersive Virtual Environments, Sanaz Saeidi, Girish Rentala, Tracey Rizzuto, Tianzhen Hong, Neil Johannsen, Yimin Zhu

Faculty Publications

Combining immersive virtual environment (IVE) with a controlled environment is a potential solution for analyzing human thermal experience during building design. Existing studies in this field have not adequately analyzed scenarios involving stabilized comfortable and uncomfortable temperature conditions using both thermal state votes and physiological responses, or the influence of the seasons. By combining IVE with a climate chamber, called mixed IVE (MIVE) in this study, experiments were conducted to test the hypothesis that participants' virtual experience did not significantly alter their thermal experience compared to their in-situ experience. Response variables were the control temperature distribution, the thermal state vote …

December 1, 2021 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Acute Consumption Of A Sugar-Sweetened Beverage Impairs Microvascular Function In Midwestern Hispanic Males, Emma Hirshman, Anne R. Crecelius

Health and Sport Science Faculty Publications

Hispanic males are at risk for cardiovascular disease and consume high levels of sugar-sweetened beverages (SSB); yet, their acute vascular response to SSBs is unknown. Ten healthy Hispanic men (18-45 years old) consumed a SSB and reactive hyperemia was performed prior to, immediately following, and 1-hr post-consumption. Both peak and total (area under the curve) forearm blood flow were attenuated immediately following consumption but returned to at or above pre-consumption levels at the 1-hr test.

A Method For The Identification Of Covid-19 Biomarkers In Human Breath Using Proton Transfer Reaction Time-Of-Flight Mass Spectrometry, Aikaterini Liangou, Antonios Tasoglou, Heinz J. Huber, Christopher Wistrom, Kevin Brody, Prahlad G. Menon, Thomas Bebekoski, Kevin Menschel, Marlise Davidson-Fiedler, Karl Demarco, Harshad Salphale, Jonathan Wistrom, Skyler Wistrom, Richard J. Lee

Emergency Medicine Articles

Background: COVID-19 has caused a worldwide pandemic, making the early detection of the virus crucial. We present an approach for the determination of COVID-19 infection based on breath analysis.

Methods: A high sensitivity mass spectrometer was combined with artificial intelligence and used to develop a method for the identification of COVID-19 in human breath within seconds. A set of 1137 positive and negative subjects from different age groups, collected in two periods from two hospitals in the USA, from 26 August, 2020 until 15 September, 2020 and from 11 September, 2020 until 11 November, 2020, was used for the method …

The Role Of Berberine, A Clinically Relevant Plant Derived Alkaloid, In T Cell-Mediated Immunosuppression, Alexandra Adorno Vita

Dissertations

The primary focus of this research was to determine the effect of berberine (BBR), a clinically relevant plant-derived alkaloid, on follicular T helper (Tfh) cell activation and differentiation, with implications for the generation of T cell-dependent humoral responses. This research revealed a novel function of BBR as a suppressor of Tfh cell proliferation in secondary lymphoid organs of BBR-treated mice that underwent immunization for arthritis induction in a collagen-induced arthritis (CIA) mouse model. Tfh cells provide signaling to B cells that is crucial for the generation of T cell-dependent humoral responses, such as affinity maturation, isotype class switching, and the …

Physiological And Mechanical Comparisons Between Clipless And Flat Pedals, Katelyn Conroy

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to investigate the physiological and mechanical comparisons between clipless and flat pedals. Participants (n=4) completed two at-home 20-minute FTP tests: using clipless and flat pedals using Zwift. The order of conditions were randomized for each participant. Participants used their personal Smart Trainers, clipless pedals, and cycling shoes while flat pedals were provided (Syun-LP, Road Bike Platform Pedals). Power, heart rate and cadence were recorded and used for analysis. All dependent variables were compared using paired t-tests. Power was significantly greater for clipless (226.7 ± 46.2 W) vs. flat (215.2 ± 41.8 W) pedals (p …

Arion 33: A Prospective Mission To Near-Earth Asteroids, Alita Regi

Theses and Dissertations

Near-Earth asteroids will become primary targets for space industrialization in the future as humanity becomes a multi-planetary species. But before such missions, it is necessary to survey these asteroids for their intrinsic scientific value. Exploring asteroids via orbiter missions can help us understand the asteroid's surface composition while providing us a cost and power model required for future missions. Therefore, it is beneficial to study asteroids to pave the way for future mining operations or more comprehensive scientific explorations. Hence, in this thesis, the target asteroids 2011 UW158 and 65803 Didymos are selected as case studies for the hypothetical mission …

Secure Data Collection And Analysis In Smart Health Monitoring, Pei Huang

All Dissertations

Smart health monitoring uses real-time monitored data to support diagnosis, treatment, and health decision-making in modern smart healthcare systems and benefit our daily life. The accurate health monitoring and prompt transmission of health data are facilitated by the ever-evolving on-body sensors, wireless communication technologies, and wireless sensing techniques. Although the users have witnessed the convenience of smart health monitoring, severe privacy and security concerns on the valuable and sensitive collected data come along with the merit. The data collection, transmission, and analysis are vulnerable to various attacks, e.g., eavesdropping, due to the open nature of wireless media, the resource constraints …

Influencing The Inflammatory Response Through Multi-Scale Geometry, Antibiotic Release, And Fluid Management In A Textile-Based Biomaterial Wound Dressing, Elizabeth Gianino

All Dissertations

The total population of diagnosed and undiagnosed diabetes mellitus in the United states is expected to rise by 54% between the years of 2015 and 2030 contributing to $200 billion in health care expense. The exponential rise in common diabetic wounds, such as diabetic foot ulcers, puts a large population at risk for complications such as infection, amputation, and even death. Peripheral neuropathy leading to late diagnoses, patient non-compliance, and lack of holistic treatment options all contribute to complications with the incidence of new ulcer formation after treatment reaching 50%. This work explores the design, development, and in vitro evaluation …

20-Degree Elevation To Reduce Swelling And Pain After Lower Extremity Open Reduction And Internal Fixation Surgery, Eni Purwanty, Riri Maria, Masfuri Masfuri

Jurnal Keperawatan Indonesia

Surgery for open reduction and internal fixation (ORIF) causes tissue swelling and pain in the surgical area. Swelling and pain can be reduced by performing distal elevation in the area of surgical ORIF. This study aimed to determine the effect of a 20° elevation on swelling and pain level of patients after surgery for ORIF of the lower extremities. A quasi-experimental design with one intervention group (pretest and posttest) and one control group was implemented. Thirty-four post-operative ORIF patients treated in one hospital in South Sumatera met the inclusion criteria and were divided into intervention and control groups. Swelling circumference …

Exercise Training Attenuates Ovariectomy-Induced Alterations In Skeletal Muscle Remodeling, Apoptotic Signaling, And Atrophy Signaling In Rat Skeletal Muscle, Eun-Jeong Cho, Youngju Choi, Jiyeon Kim, Jun Hyun Bae, Jinkyung Cho, Dong-Ho Park, Ju-Hee Kang, Jin Hwan Yoon, Eunmi Park, Dae Yun Seo, Sukho Lee, Hyo-Bum Kwak

Kinesiology Faculty Publications (Archived)

Purpose

Methods

Results

Exclusive Breastfeeding And Professionals From The Family Health Strategy, Marialda Moreira Christoffel, Ana Leticia Monteiro Gomes, Cássia Leoneuza Augusto Julio, Julia Florentino De Barros, Elisa Da Conceição Rodrigues, Fernanda Garcia Bezerra Góes, Ana Maria Linares

Nursing Faculty Publications

OBJECTIVES: to analyze the perception of health professionals about exclusive breastfeeding in Family Health Strategy units in the city of Macaé.

METHODS: qualitative study carried out in four units of the Family Health Strategy in the city of Macaé, Rio de Janeiro. Thirty health professionals were interviewed from March to May 2019. Textual contents were processed in the IRaMuTeQ^® software by the Descending Hierarchical Classification.

RESULTS: professionals use different strategies for actions to promote, protect and support breastfeeding in prenatal consultations, but social and cultural determinants are important issues that interfere in this process, the involvement of the family …

Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurodegenerative conditions. In this study, we present a predictive NMS model that uses an embedded neural architecture within a finite element (FE) framework to simulate muscle activation. A previously developed neuromuscular model of a motor neuron was embedded into a simple FE musculoskeletal model. Input stimulation profiles from literature were simulated in the FE NMS model to verify effective integration of the software platforms. Motor unit recruitment and rate coding …

Forecasting The Prospects Of Female Judoists Of Youth Age Based On Indicators Of Their Functional State, Umid Abduhamidovich Alimov

Eurasian Journal of Sport Science

Purpose: To justify the prediction by long-term training in women's judo. The article presents a functional analysis of the problem of the prospects for the development of female judoists of 17-18 years of age. The content of the presented work is fundamentally different from most generalizing works. The material of general scientific and special nature is presented, providing an individual approach to forecasting, working capacity and restoration of physical fitness of athletes. The content of the article is based on the research of female judoka in the period of the formation of sportsmanship.

Methods: Harvard step test - to determine …

Medical School Watercooler Newsletter - November 18, 2021, Lindsey Lyle

Watercooler Newsletter

This is the November 18, 2021 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Medical student chosen for national AAMC advisory task force
• Foot and ankle surgeon joins Department of Orthopaedic Surgery
• Video online: 'Skull Base Neurosurgery and Brain Tumors'
• Nicotine weakens immune system, USA researchers find

The Potential Health Effects Of Bacterial Use In Self-Healing Concrete: A Systematic Literature Review, Brandon Polimeni, Moses Karakouzian Ph.D.

Undergraduate Research Symposium Posters

In due course, structures developed from concrete create microcracks exposing it to degradation via the reinforcement steel's formation of ferric oxide. The aforementioned declines the loading capacity and lessens durability. A corrective technique used to counteract the effects above is bio-mineralization, self-healing the crevices with microorganisms' metabolic processes. Literature has explored some specific organisms used, and the research strongly supports that the existing bacteria used positively strengthen the concrete's durability. This literature analysis examines if the selected microorganisms: Sporosarcina pasteurii, Lysinibacillus sphaericus, Bacillus cereus, and Bacillus subtilis used in some current constructional methods will harm the health of consumers or …

Investigating A Frisian Genetic Mutation, Sarah Moss

The Voice

No abstract provided.