Digital Commons Network^™

Suppression Of Il-1Β Promotes Beneficial Accumulation Of Fibroblast-Like Cells In Atherosclerotic Plaques In Clonal Hematopoiesis, Trevor P Fidler, Andrew Dunbar, Eunyoung Kim, Brian Hardaway, Jessica Pauli, Chenyi Xue, Sandra Abramowicz, Tong Xiao, Kavi O'Connor, Nadja Sachs, Nan Wang, Lars Maegdefessel, Ross Levine, Muredach Reilly, Alan R Tall

Faculty, Staff and Student Publications

Clonal hematopoiesis (CH) is an independent risk factor for atherosclerotic cardiovascular disease. Murine models of CH suggest a central role of inflammasomes and IL-1β in accelerated atherosclerosis and plaque destabilization. Here we show using single-cell RNA sequencing in human carotid plaques that inflammasome components are enriched in macrophages, while the receptor for IL-1β is enriched in fibroblasts and smooth muscle cells (SMCs). To address the role of inflammatory crosstalk in features of plaque destabilization, we conducted SMC fate mapping in Ldlr-/- mice modeling Jak2VF or Tet2 CH treated with IL-1β antibodies. Unexpectedly, this treatment minimally affected SMC differentiation, …

Considerations On Design And Analysis Of External Control In Pediatric Oncology, Jingjing Ye, Haitao Pan, Gregory Reaman, Satrajit Roychoudhury, Chengxing Lu, Lindsay A Renfro, Yuan Ji, Rong Liu, Ying Yuan, Weidong Zhang

Faculty, Staff and Student Publications

Pediatric cancer consists of a diverse group of rare diseases. Due to limited patient populations, standard randomized and controlled trials are often infeasible. As a result, single-arm trials are common in pediatric oncology and the use of external controls is often desirable or necessary to help generate actionable evidence and contextualize trial results. In this paper, we illustrate unique features in pediatric oncology clinical trials and describe their impact on the use of external controls. Various types of relevant external control data sources are described in terms of their utility and drawbacks. Statistical methodologies and design implications with external control …

Polaris: A Phase 2 Trial Of Encorafenib Plus Binimetinib Evaluating High-Dose And Standard-Dose Regimens In Patients With Braf V600-Mutant Melanoma With Brain Metastasis, Alexander M Menzies, Georgina V Long, Amiee Kohn, Hussein Tawbi, Jeffrey Weber, Keith Flaherty, Grant A Mcarthur, Paolo A Ascierto, Yanina Pfluger, Karl Lewis, Katy K Tsai, Omid Hamid, Hans Prenen, Luis Fein, Erjian Wang, Carolin Guenzel, Fan Zhang, Joseph F Kleha, Alessandra Di Pietro, Michael A Davies

Faculty, Staff and Student Publications

Background: POLARIS (phase 2 [ph2]; NCT03911869) evaluated encorafenib (BRAF inhibitor) in combination with binimetinib (MEK1/2 inhibitor) in BRAF/MEK inhibitor-naïve patients with BRAF V600-mutant melanoma with asymptomatic brain metastases.

Methods: The safety lead-in (SLI) assessed tolerability for high-dose encorafenib 300 mg twice daily (BID) plus binimetinib 45 mg BID. If the high dose was tolerable in ph2, patients would be randomized to receive high or standard dose (encorafenib 450 mg once daily [QD] plus binimetinib 45 mg BID). Otherwise, standard dose was evaluated as the recommended ph2 dose (RP2D). Patients who tolerated standard dosing during Cycle 1 could be dose …

Evaluation Of Baseline F-18 Fdg Positron Emission Tomography In The Diagnosis And Assessment Of Giant Cell Arteritis, Burak İnce, Emine Göknur Işik, Zeynep Gözde Özkan, Yasemin Yalçinkaya, Bahar Artım Esen, Ahmet Gül, Murat İnanç

Turkish Journal of Medical Sciences

The aim of this study is to evaluate the baseline F18-FDG PET/CT findings of individuals diagnosed with giant cellarteritis (GCA) and to explore its association with clinical findings and classification criteria.Materials and methods: We analysed data from patients who underwent F18-FDG PET/CT scans to investigate large vessel (LV)involvement between 2010 and 2019. Only patients with a clinical diagnosis of GCA and at least 6 months of follow-up were included.We compared initial clinical features and laboratory findings based on the presence of LV vasculitis on PET/CT and the maximumstandard uptake value (SUVmax) of vascular territories.Results: Twenty-nine patients (median age at diagnosis: …

Savings Associated With Surgical Aortic Valve Replacement With A Resilia Tissue Valve Based On Seven-Year Commence Trial Results, Tom Nguyen

All Publications

Background: Bioprostheses with RESILIA tissue demonstrate a reduction in calcification and improve health outcomes in pre-clinical and clinical studies. Prior economic analyses which relied on 5 years of evidence from the COMMENCE trial demonstrate financial savings for RESILIA tissue valves relative to mechanical valves after surgical aortic valve replacement (SAVR). Given the recent release of 7-year COMMENCE data, this economic evaluation updates the estimate for long-run savings of bioprosthetic valves with RESILIA.

Methods: Simulation models estimated disease progression across two hypothetical SAVR cohorts (tissue vs. mechanical) of 10,000 patients each in the US. The primary comparison calculated the SAVR-related expenditures …

Anne, Martin, Emmett, And Harriet: Plays About Anne Frank And Historical African American Personages, Erin R. Scheidegger-Menendez

Antioch University Dissertations & Theses

Anne Frank is linked to her contemporaries in about 80% of 18 English-language published and produced plays. The remaining plays pair Frank and African American icons Harriet Tubman, Emmett Till, and Martin Luther King, Jr. Research on dramatic literature with Frank as a character, the writing of plays linking her with African American personages, or history, analysis, or comparison of the process of multiple plays about Frank does not exist. A few articles extant compare the Goodrich and Hackett play with the Kesselman rewrite, a dissertation on five plays about Frank (those five plays are in the 80% mentioned earlier). …

The Lived Experiences Of Sex Offenders: Perceptions Of Pedophilic Offenders Regarding Engagement In Community Treatment, Ali K. Madrid

Antioch University Dissertations & Theses

Pedophilia is a complex, multifaceted disorder that has existed, in some form, throughout all of human history. It was not until 1952, with the inception of the Diagnostic and Statistical Manual of Mental Disorders (DSM-1), that it was officially characterized as a psychiatric disorder. Treatment options have included surgeries, medications, cognitive behavior therapy, combined treatments (antiandrogenic drug and psychotherapy), and preventative programs. Pedophilic offenders released to the community must complete approved treatment. The community treatment may be manualized, evidence-based and likely to be effective. However, the offender must be willing and able to access the treatment resources. Participation in community …

Examination Of The Differences And Similarities In The Classification Of Multiple Homicide Perpetrators, Lucy M. Papp

Theses and Dissertations

The applied dissertation compares the lifestyle and behavioral characteristics of mass, serial, and spree murderers. Historically, studies have focused on serial murder according to the perpetrator's typology or indicators at the crime scene. The current topics of research lack a comparison of these classifications. While the classification and described typologies are essential for academic and investigative purposes, understanding the impactful lifestyle factors of these perpetrators may also serve as an essential factor in predictive analysis, victimology, and the motive behind their heinous crimes.

The researcher collected data on the classifications for each type of multiple homicide perpetrator: mass, serial, and …

Through A Glass Darkly: Tplf Viewed Through A Procedural Lens, Richard L. Marcus

Faculty Scholarship

Legal responses to litigation funding could take many forms—consumer protection, regulation of interest rates and fees, perhaps even prohibition (as under the old doctrines of champerty and maintenance). In the U.S., procedural responses, often emphasizing disclosure of funding, have featured prominently. From the perspective of one directly involved in the U.S. rulemaking effort, this Article explores the challenges of designing such a rule. Among other things, it notes that litigation funding actually could support important law-implementation features of American litigation. But a host of uncertainties mean that for the present, the future of mandated disclosure of funding remains unclear, as …

The Monster Mash: A Monster Studies Approach To Literature In The University Classroom, Megan L. Bowen

College of Graduate Studies: Theses & Dissertations

The Monster Mash is a course proposal for an upper-division undergraduate literature course focused on exploring monsters in literature and building connections between classic and more contemporary texts using high-impact practices (HIPs) with student success in mind. I build on previous work in the field of Monster Studies and introduce my own original monster pattern that prompts students to interpret monsters as they trek through Origin, Separation, Power, Threat, and Diminishment. This pattern highlights commonalities when it comes to the representation of monsters and their stories, allowing students to identify them across texts. I also divide monsters into three categories …

The Role Played By Non-Formal Education In The Lives Of Iraqi-British Citizens: A Study Of Three Iraqi-British Cultural Institutions And How Non-Formal Education Empowers Individuals And Communities, Nadeem Al-Abdalla

School of Law, Humanities and Social Sciences Theses

This thesis highlights the role played by non-formal education in the lives of Iraqi community members who participate in the activities offered by London’s Iraqi-British cultural centres. The key aims of this thesis were; to research, document and analyse London’s Iraqi community and their experiences of non-formal learning within Iraqi cultural centres; and to establish the extent to which they found their participation in this non-formal learning empowering, both at an individual and community level. Many studies have been conducted into the lives of newly arrived communities. Generally, these studies tend to focus on their early years in the UK …

Valuation’S Role In The Investment Decisions Process A Mixed Method Study, Joseph D. Foresi

Open Access Dissertations

The inspiration for this dissertation began as a practitioner. As a Wall Street equity analyst, I calculated the valuation of various types of stocks using relative and intrinsic valuation methods on a daily basis. I noticed an interesting phenomenon while performing these calculations. The estimated stock prices were often largely disconnected from the actual stock market price leading me to wonder what the role of estimated valuations was in the overall investment process.

I believe there is a separation between a stock’s market price and fundamental value consistent with the “Noise” Trader Model (NTM). If this is true, a researcher …

Antiangiogenic Therapy Combined With Immune Checkpoint Blockade In Urothelial Cancer: Systematic Review And Meta-Analysis, Mohammad Jad Moussa, Iuliia Kovalenko, Emanuele Crupi, Ekaterina Proskuriakova, Yimin Geng, Giuseppe Fallara, Raed Benkhadra, Daniele Raggi, Matthew T. Campbell, Pavlos Msaouel, Omar Alhalabi

Department of Medicine Faculty Publications

Background: Antiangiogenic therapy had been tested in urothelial cancer (UC) without reaching the clinic.

Objective: We provide a systematic review and meta-analysis of trials to assess efficacy of immune checkpoint inhibitors (ICI) combined with antiangiogenic agents in UC.

Methods: Following PRISMA guidelines, we searched for trials with at least one arm of patients with UC treated with ICI plus antiangiogenics. Data were analyzed with the "meta" package from R using a one-staged frequentist meta-analysis.

Results: After screening 13,708 titles and abstracts, 9 studies were selected for analysis with 14 identified cohorts comprising 621 patients: 448 were ICI-naïve (ICI-N) and 173 …

Love And Solitude In Latin America: An Actor’S Take, Performing Graciela In Diatriba De Amor Para Un Hombre Sentado By Gabriel Garcia Marquez, Claudia C. Sevilla

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis I take a journey through twentieth century Latin America through inhabiting the role of Graciela created by the late great Gabriel Garcia Marquez in his only work of theatre. Through detailed historical research I explore human topics such as marriage and isolation embodied in Graciela that in a sense mirror a people and a continent. The challenges of producing a play with no budget or partners and the freedoms and constraints of performing a one-person show, which included an audience that does not speak the language the play is written in. How does an actor adapt to …

Investigating The Role Of Spinal Motoneuron Organization In Human Motor Control, Rachel I. Taitano

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mechanisms of voluntary motor control are complex and require inputs via cortical centers, peripheral sensory systems, and spinal inputs such as central pattern generators. It is hypothesized that control is simplified via utilization of motor primitives, which may rely on structures within the spinal cord, however this remains unknown in both human and non-human primates. The goal of this dissertation is to characterize muscle activity in the upper extremity in relation to the corresponding anatomical organization of spinal motoneurons to provide insight into how primitives are both organized and activated to produce movement.

The first aim of this work was …

A Legacy Of Labor: Maternity Narratives In 1960s And 1970s North American Life Writing, Katelynn Ann Vogelpohl

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

A Legacy of Labor: Maternity Narratives in 1960s and 1970s North American Life Writing

Katelynn Ann Vogelpohl

The phenomenon of maternity has been repeatedly described as an event that shakes the very foundations of social and physical identity. As the flesh of the pregnant person literally divides to produce new life, one subject becomes enclosed within another, dramatically affecting the pregnant person’s sense of self and causing a confluence of intense, and often conflicting, feelings. In North America, there are two dominant, and seemingly opposing, discourses on pregnancy and childbirth: the institutional medical discourse and the natural childbirth discourse. …

Front Matter

The Gettysburg Historical Journal

Front Matter of the Gettysburg Historical Journal 2024

Gettysburg Historical Journal 2024

The Gettysburg Historical Journal

Complete Issue of the Gettysburg Historical Journal 2024

Featured Piece: The Historians Of Tiktok, Hannah Greenwald

The Gettysburg Historical Journal

This year’s featured piece was written by Hannah Greenwald, an assistant professor in the History department. Professor Greenwald teaches classes on Latin American history, Atlantic history, and borderlands history. Her research focuses on Indigenous resistance, settler colonialism and nation-state formation.

Beyond Discrimination: Market Humiliation And Private Law, Hila Keren

University of Colorado Law Review

Market humiliation is a corrosive relational process to which the law repeatedly fails to respond due to the law’s heavy reliance on the discrimination paradigm. In this process, providers of market resources, from housing and work to goods and services, use their powers to reject or mistreat other market users due to their identities. They thus cause users severe harm and deprive them of dignified participation in the marketplace. The problem has recently reached a peak. The discussion in 303 Creative v. Elenis indicates that the Supreme Court might legitimize market humiliation by granting private providers broad free speech exemptions …

Police Vigilantism, Nadia Banteka

Scholarly Publications

This Article uncovers a critical yet unexplored dimension of policing: the strategic oscillation of police officers between their roles as state actors and private individuals, and its significant implications for police accountability frameworks. As officers toggle between these two roles to their legal advantage, they exploit a deep, systemic flaw in the structural design of policing. Tracing the trajectory of policing from its vigilante origins to its institutionalized form today, this Article argues that contemporary policing merges state-sanctioned power with vestiges of vigilantism to blur the public-private divide. This duality enables a form of state-sanctioned vigilantism through which officers exploit …

The Liber Scintillarum: Excerpting And Recomposing Textual And Artistic Traditions In The Early Middle Ages, Loretta Vandi

Peregrinations: Journal of Medieval Art and Architecture

No abstract provided.

Fighter, Player, Hunter: Queer Women And Female Agents On Secular Gothic Ivories, Emma Le Pouésard

Medieval Feminist Forum: A Journal of Gender and Sexuality

This essay shines a light on the previously ignored queer representations of women on Gothic secular ivories, taking as its case studies three popular iconographical themes: the Castle of Love, the game of chess, and the courtly hunt. Refusing to yield to compulsory heterosexuality when looking at the indeterminately gendered bodies that populate these objects reveals both the ivories’ inherent queerness and their potential to interrogate their own normativity. Like the romance literature that inspired the images on these objects, they represent and enforce idealized gender norms with remarkable reluctance. In particular, the author highlights overlooked depictions of female homosocial …

Medieval Feminist Forum: A Journal Of Gender And Sexuality 59.1 (2023)

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Use Of Social Media In Public Archives: Perspectives About Ghana’S Readiness And Perceived Challenges., Reuben Saah, Samuel Abban, Esther White

Journal of Contemporary Archival Studies

The study explored the readiness and challenges of social media adoption at the Public Records and Archives Administration Department (PRAAD) in Ghana and was guided by the Iacovou, Charalambos L., Izak Benbasat, and Albert S. Dexter model of Electronic Data Interchange adoption. Using the qualitative approach, 13 participants drawn from the Archives Division were interviewed to explore their perspectives. The results showed that besides the participants high understanding and awareness of the benefits of social media adoption, clients were interested to engage PRAAD on social media. However, PRAAD’s readiness to adopt and effectively use social media was inadequate due to …

The “Mother's Heart”: Social Networks And Smallpox Inoculation In The 18th Century, Jennalyn Welsh Mackay

History Theses, Dissertations, and Student Creative Activity

In 1721 the practice of inoculation was put on trial in the American colonies. This incredible medical advancement, practiced for centuries in different parts of the world, had an irregular but unforgettable impact on the eastern seaboard of the North American continent. Inoculation provided individuals and families with an opportunity to control this terrible scourge, however, few were keen to initially take on the risk. The history of inoculation throughout the world and especially in Europe has been well studied. Even as the debate raged, physicians wrote their own histories on the subject. Less studied is the impact that women’s …

This Land Is Our Land: Tree Planting And Environmental Construction On The Nebraska Prairie, Megan Sue Launchbaugh

History Theses, Dissertations, and Student Creative Activity

In 1895 the Nebraska Legislature passed a bill officially adopting the nickname the “Tree Planter’s State” on account of the founding of Arbor Day, the Timber Culture Act of 1873, and the “millions of trees planted by early settlers as windbreaks, woodlots, and orchards.” Since that time, Arbor Day and the Timber Culture Act have been the subject of countless historical studies, while the subject of settler tree planting remains largely unexplored. This thesis seeks to begin establishing a place for the stories, experiences, and legacy of settler tree planting within the regional narrative by examining the cultural, physical, and …

Enemies Of All Mankind: Piracy In The British Atlantic World, 1680 To 1730, Nicholas Knuth

History Theses, Dissertations, and Student Creative Activity

Pirates during the late seventeenth and early eighteenth centuries experienced the height of Atlantic piracy. The Golden Age of Piracy caused major political problems for the British overseas colonies and constituted revisions in colonial governance. Piracy during this period began as buccaneers who worked for the state during wartime as privateers and rogues during peacetime. This group changed however, by the end of the seventeenth century had transitioned into pirates, attacking any and all shipping around the colonies regarless of origin. This group forced Parliaments’ hand to act against them and implement anti-piracy laws throughout the empire. However, the War …

Teaching Critical Race Media Literacy Through Black Historical Narratives, Christine Mcwhorter, Tiffany Mitchell Patterson

Journal of Media Literacy Education

On the 400th anniversary of American enslavement the New York Times (NYT) 1619 project launched an interactive digital experience including a popular podcast centering the contributions and narratives of Black Americans. This study sought to understand how HBCU students responded to learning Black music history through what we term a “pop culture podcast.” This study explored the ways in which this particular podcast could support the development of Critical Race Media Literacy (CRML) based on a media discourse at a Historically Black College/University (HBCU). This study employed survey research and focus group discussions with HBCU students in two courses. The …

Progress And Prospects On Institutional System Construction Of Ecological Civilization In China, Linsheng Yang, Yanan Guo, Huiyi Zhu, Gaodi Xie, Xiaoyong Liao, Quansheng Ge

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since the 18th National Congress of the Communist Party of China, the construction of Ecological Civilization (EC) in China has undergone historic, transitional, and comprehensive changes from theory to practice. The construction of system is the core content and the basic guarantee for the success of EC construction. Based on the government documents of EC construction and related research literatures, this study analyzes the formation and evolution characteristics of China’s EC construction system, parses the development process of representative innovation policies, and then predicts the trend of the further deepening reform of EC system. The results show that the relevant …