Digital Commons Network^™

Irx2 And Nptx1 Differential Regulation Of Β-Catenin Underlies Mek-Mediated Proliferation In Human Neuroglial Cells, Alexander Chen, Hannah Wang, Xuanwei Li, Corina Anastasaki, David H Gutmann

2020-Current year OA Pubs

The two major genomic alterations in pediatric pilocytic astrocytoma (PA) are

Validation Of A Dynamic Risk Prediction Model Incorporating Prior Mammograms In A Diverse Population, Shu Jiang, Debbie L Bennett, Graham A Colditz

2020-Current year OA Pubs

IMPORTANCE: For breast cancer risk prediction to be clinically useful, it must be accurate and applicable to diverse groups of women across multiple settings.

OBJECTIVE: To examine whether a dynamic risk prediction model incorporating prior mammograms, previously validated in Black and White women, could predict future risk of breast cancer across a racially and ethnically diverse population in a population-based screening program.

DESIGN, SETTING, AND PARTICIPANTS: This prognostic study included women aged 40 to 74 years with 1 or more screening mammograms drawn from the British Columbia Breast Screening Program from January 1, 2013, to December 31, 2019, with follow-up …

Virtual Patient-Pcp-Hospitalist Care Transition Meeting Before Hospital Discharge, Jing Li, Matthew D Reuter, Jennifer M Schmidt, Nathan Moore, Nickole Forget, Jennifer Carron, Janice K Ernest, Mark V Williams

2020-Current year OA Pubs

IMPORTANCE: The fragmented health care system presents significant challenges to promoting trust with hospitalized patients.

OBJECTIVE: To test the feasibility and perceptions of a digital connection tool for communication among patients, hospitalists, and primary care practitioners (PCPs).

DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study was conducted as a feasibility pilot study from September 2022 to June 2023 on medical floors across 3 hospitals. Participants included adult inpatients, the hospitalists who managed their care, and the patients' PCPs. Data were analyzed from September 2023 to April 2025.

EXPOSURE: Structured, video-mediated interaction among the patient, family caregiver (if available), hospitalist, and …

Social, Microbial, And Immune Factors Linking Bacterial Vaginosis And Infectious Diseases, Nicole M. Gilbert, Luis A. Ramirez Hernandez, Daniela Berman, Sydney Morrill, Pascal Gagneux, Amanda L. Lewis

2020-Current year OA Pubs

Bacterial vaginosis (BV) is a polymicrobial condition of the vaginal microbiota associated with a variety of sexually transmitted infections, infections of maternal and fetal tissues during pregnancy, and even some infections outside of the reproductive tract, including the urinary tract and mouth. BV has also been associated with conditions in which the body generates prominent inflammatory reactions to microbes, including infections of the cervix and other upper genital tract tissues. For reasons still not understood, BV is a highly recurrent and often difficult-to-treat condition, complicating attempts to prevent these associated infections. An additional layer of complexity arises from the increasing …

Is Ride-Hailing A Potential Solution For Older Adults After Driving Cessation? The Role Of Objective And Perceived Accessibility, Minju Kim Song

Dissertations and Theses

Due to age-related physical and cognitive changes, older drivers have a greater risk of crashes and are restricted by age-dependent regulation. Nonetheless, many older adults in the United States maintain a car-dependent lifestyle and still prefer driving. When driving cessation or reduction becomes necessary, a primary concern is finding suitable alternative transportation modes. However, the availability of alternative transportation modes does not guarantee their actual use of these options.

As a relatively new transportation mode, ride-hailing services, such as Uber and Lyft, offer on-demand, door-to-door transportation and may be a feasible transportation solution for older adults who stop driving. While …

Identification Of A Seasonal Influenza Vaccine-Induced Broadly Protective Neuraminidase Antibody, Anders Madsen, Nisreen M A Okba, Tossapol Pholcharee, Hanover C Matz, Huibin Lv, Maria Ibanez Trullen, Julian Q Zhou, Jackson S Turner, Aaron J Schmitz, Fangjie Han, Stephen C Horvath, Sameer Kumar Malladi, Florian Krammer, Nicholas C Wu, Ali H Ellebedy

2020-Current year OA Pubs

Seasonal influenza viruses cause significant global illness and death annually, and the potential spillover of avian H5N1 poses a serious pandemic threat. Traditional influenza vaccines target the variable hemagglutinin (HA) protein, necessitating annual vaccine updates, while the slower-evolving neuraminidase (NA) presents a promising target for broader protection. We investigated the breadth of anti-NA B cell responses to seasonal influenza vaccination in humans. We screened plasmablast-derived monoclonal antibodies (mAbs) from three donors, identifying 11 clonally distinct NA mAbs from 268 vaccine-specific mAbs. Among these, mAb-297 showed exceptionally broad NA inhibition, effectively protecting mice against lethal doses of influenza A and B …

Innate Lymphoid Cells In Inflammatory Bowel Disease, Xin Yao, Kaiming Ma, Yangzhuangzhuang Zhu, Siyan Cao

2020-Current year OA Pubs

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder of the gastrointestinal tract with rising incidence and an unclear etiology. Innate lymphoid cells (ILCs) have recently emerged as key regulators of mucosal immunity and tissue homeostasis and are increasingly implicated in IBD. Unlike adaptive lymphocytes, ILCs do not require antigen recognition and clonal expansion to respond rapidly to environmental cues and shape immune responses. In a healthy gut, ILCs maintain intestinal homeostasis by guarding the epithelial barrier, protecting against pathogens, and mounting proper responses to external insults. However, their altered differentiation, proliferation, recruitment, activation, …

Cytarabine Pharmacogenomics And Outcomes Among Children And Young Adults With Acute Myeloid Leukemia, Richard J Marrero, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Therapeutic responses in acute myeloid leukemia (AML) demonstrate considerable variability both across and within established risk stratifications and age groups. Moreover, significant racial disparities persist, with Black patients experiencing inferior survival outcomes compared with their White counterparts.

OBJECTIVE: To validate the association of the previously reported 10 single nucleotide variant (SNV)-based ara-C pharmacogenomics score (ACS10) with survival outcomes in a large cohort of pediatric AML patients; to evaluate whether ACS10 remains relevant in an adolescent and young adult (AYA) population of patients with AML treated with similar intensive induction chemotherapy protocols; and to assess the association of ACS10 with …

Multicenter Validation Of A Machine Learning Model For Surgical Transfusion Risk At 45 Us Hospitals, Sunny S Lou, Sayantan Kumar, Charles W Goss, Michael S Avidan, Sachin Kheterpal, Thomas Kannampallil, Multicenter Perioperative Outcomes Group

2020-Current year OA Pubs

IMPORTANCE: Accurate estimation of surgical transfusion risk is important for perioperative planning and effective resource allocation. Most machine learning models in health care are not validated or perform poorly in external settings.

OBJECTIVE: To externally validate a publicly available machine learning algorithm (Surgical Personalized Anticipation of Transfusion Hazard [S-PATH]) to estimate red cell transfusion during surgery within a national sample of hospitals.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study evaluated all surgical cases performed in 2020 or 2021 at 45 US hospitals participating in the Multicenter Perioperative Outcomes Group. Obstetric and nonoperative cases were excluded. Data analysis was performed …

Dominant Interfering Card11 Variants Disrupt Jnk Signaling To Promote Gata3 Expression In T Cells, Bradly M Bauman, Jeffrey R Stinson, Melissa A Kallarakal, Lei Haley Huang, Andrew M Frank, Gauthaman Sukumar, Nermina Saucier, Clifton L Dalgard, Alice Y Chan, Joshua D Milner, Megan A Cooper, Andrew L Snow

2020-Current year OA Pubs

Several "primary atopic disorders" are linked to monogenic defects that attenuate TCR signaling, favoring T helper type 2 (TH2) cell differentiation. Patients with CARD11-associated atopy with dominant interference of NF-κB signaling (CADINS) disease suffer from severe atopy, caused by germline loss-of-function/dominant interfering (LOF/DI) CARD11 variants. The CARD11 scaffold enables TCR-induced activation of NF-κB, mTORC1, and JNK signaling, yet the function of CARD11-dependent JNK signaling in T cells remains nebulous. Here we show that CARD11 is critical for TCR-induced activation of JNK1 and JNK2, as well as canonical JUN/FOS AP-1 family members. Patient-derived CARD11 DI variants attenuated WT CARD11 JNK signaling, …

June 2025, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.

Association Between Health Insurance, Antiretroviral Treatment, And Hiv Preexposure Prophylaxis In Men Aged 20–85 In Virginia, Lauren Elizabeth Maxwell

Walden Dissertations and Doctoral Studies

HIV prevention and treatment disparities persist among men in Virginia, particularly in racial and ethnic minority groups. This study examined how insurance type and demographic factors influence prescriptions for antiretroviral treatment (ART) and preexposure prophylaxis (PrEP). Addressing these disparities is critical to advancing public health equity and reducing HIV rates. The purpose was to assess whether age, race, ethnicity, region, and insurance type are associated with the type of oral HIV medication prescribed. Guided by the HIV prevention and care cascade frameworks, the study focused on access and adherence. Using a cross-sectional quantitative design, the study analyzed secondary data from …

Social-Emotional Learning (Sel) Support Through Social Work Case Management In K-12 Schools, Dina Michelle Garrett-Parker

Walden Dissertations and Doctoral Studies

Existing research revealed that K-12, school-based social work clinicians were utilized in various ways to support students' social-emotional learning (SEL) needs in public K-12 schools in the United States. However, there was a gap in knowledge about the unique approaches K-12 school-based social work clinicians employed to address the SEL needs of non-at-risk students. This basic qualitative study explored how K-12 school-based social work clinicians used empowerment case management practices to address the SEL needs of non-at-risk students. The theoretical framework grounding this study was empowerment theory. Using purposive sampling, semistructured interviews were conducted with five K-12 school-based social work …

Alternatively Certified Early Childhood Special Education Teachers' Perspectives On Remaining In The Classroom, Sena Victoria Ann Belgard Dever

Walden Dissertations and Doctoral Studies

Alternative teacher certification programs are used nationwide to address the critical teacher shortage in special education. There is a gap in knowledge regarding the challenges that early childhood special education teachers experience, which make them leave the profession at twice the rate of general education teachers. The purpose of this basic qualitative study was to explore alternatively certified early childhood special education teachers’ perspectives on remaining in their teaching positions and the support they need to continue teaching. The study framework was comprised of Day and Gu’s teacher resilience theory. Data were collected from semistructured interviews with 10 prekindergarten to …

Managing Values-Based Purchasing In School Nutrition Programs, Laura Lee Benavidez

Walden Dissertations and Doctoral Studies

School nutrition managers face the challenge of balancing values-based purchasing (VBP) with maintaining student participation and budgetary stability. While VBP integrates sustainability, environmental impact, and animal safety, these priorities may sometimes compete with traditional goals, such as cost efficiency and meal accessibility. Grounded in program evaluation theory, the purpose of this mixed methods explanatory sequential study was to examine how school food service managers implement VPB, integrating procurement and nutrition transparency while managing participation and costs. The quantitative phase focused on participation trends, cost structures, and procurement metrics across diverse school districts to establish a foundation for understanding VBP’s measurable …

Using “Ways Of Thinking And Practising” To Analyse Final Year Medical Student Reflections And Underlying Concepts In Preparedness For Practice, Rachel Leyland, Hilary Neve, Elizabeth Drake, Tracey Collett

Peninsula Medical School

Introduction: Ensuring that medical students are prepared for future practice is challenging for all medical schools. Most studies of preparedness involve newly qualified doctors and use quantitative methods such as self-report surveys focused on defined competencies, and often find graduates are unprepared for the complex and challenging areas of real-world practice. Qualitative methods, using conceptual ideas linked to learning such as ‘Ways of Thinking and Practising’ (WTP) are little explored in this area but could offer rich and useful insights about graduates’ preparedness. WTP recognises that, in addition to specific knowledge and skills, students need to understand the complex links …

2025 Conference Schedule, Georgia Southern University

Southeast Conference on School Climate

N/A

Research Misconduct Sebagai Suatu Tindak Pidana Penyebaran Berita Bohong: Sebuah Tinjauan Hukum Pidana, Kemal Fikri Royadi, Monte Carlo Faza Harissa

Jurnal Hukum & Pembangunan

Research is one of the gates to uncover wisdom in scientific disciplines. In its implementation, it is often found that there are various interests underlying the research. These various interests also have their own purpose to the extent that it can influence the results of the research which can have implications to form a research misconduct. This research aims to review the national criminal law regarding this behavior by examining the relevant act’s articles as well as scholarly dogmatics due to the absence of laws regulating this matter. The method used in this research is juridical-normative using conceptual approach and …

The Aga Khan Health Services

University press releases and calendars

No abstract provided.

Aku Original Artwork, Aku Seals

Old name/logo items (letterheads, seals, posters, etc.)

No abstract provided.

Adaptive Reuse Of The Interior Design Of Heritage Buildings As Museums (Analytical Study Of Aisha Fahmy Palace, Cairo-Egypt), Nada Ahmed Arisha

Journal of Art, Design and Music

Heritage buildings convey the history of place and time, it maintains and preserves the different identities in which the building is built for. Adaptive reuse is the process of sustaining the Architecture and Interior design of the heritage building to protect, sustain and extend the age of the building and defending it from demolishing. The research illustrates the Adaptive reuse in heritage buildings which became museums after adaptation and restoration processes including mass addition and extension processes. A case study is mentioned including Aisha Fahmy Palace, which was site visited by the researcher to reveal the adaptation and restoration processes …

Proposing An Integrative Framework For Conducting Empirical Research On Culture-Inspired Product Design, Peter Oluwagbenga Odewole, Michael Abiodun Oyinloye, Johnson Olarinde Oladesu

Journal of Art, Design and Music

In developing African countries, such as Nigeria, the intersection of culture and product design poses a multifaceted challenge that demands comprehensive investigation. The existing body of research needs an integrative framework that adequately addresses the intricate dynamics involved in culture-inclined product design processes within these specific socio-economic and cultural contexts. This deficiency hampers the ability of designers, researchers, and policymakers to develop effective strategies for creating products that resonate with their diverse cultural heritage. Using a qualitative research method based on secondary data, this study develops an integrative framework for conducting empirical research on culture-inspired product design focusing on Nigeria, …

Survey On Seed Biology And Pharmacological Properties Of Four Important Species, Mohamad Hesam Shahrajabian, Wenli Sun

Bulletin of Faculty of Pharmacy Cairo University

Medicinal and aromatic plants are gaining more importance because of their potential application in food, pharmaceutical and fragrance industry. Medicinal and aromatic plants have been used in cosmetics, perfumery, pharmaceuticals and food flavoring since ancient times, because of the presence of essential oils and different components. Seeds are of immense economic and biological importance, and they contain high oil, protein and starch reserves. The seeds of medicinal and aromatic plants are stores of important and active secondary metabolites that have been economically and commercially beneficial and helpful for medicine and pharmacy. The seeds of fennel are highly nutritious, and the …

Michigan Ophthalmology Pathway Program: Five Years Of Aiming To Increase Diversity In Ophthalmology, Keith D. Miller, Karthik Reddy, Anna Kay, Mickey Nguyen, Rafik Issa, Lena Juratli, Mikaelah Johnson Griggs, Mana Yacim, Alan Sugar, Ariane Kaplan

Journal of Academic Ophthalmology

Introduction: Ophthalmology is one of the least diverse medical subspecialties. The Michigan Ophthalmology Pathway (MOP) Program was created at the University of Michigan Medical School in 2017 to promote diversity in ophthalmology through early exposure and longitudinal mentorship for medical students from underrepresented backgrounds (URiM). This innovative institution-level model aimed to increase URiM student interest in ophthalmology and help URiM students develop competitive residency applications. Methods: Each year, first-year medical students (M1) and residents (PGY2) were invited to apply to MOP. MOP mentees were matched one-to-one with an ophthalmology resident mentor whom they shadowed for six days in the clinic …

A Descriptive Analysis Of The Current State Of Peace Officer Standards And Training Physical Fitness Requirements Across The Usa, Robert G. Lockie, Joseph Dulla

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 543-560, 2025. Many law enforcement organizations are experiencing recruitment and retention challenges, of which physical fitness can be a factor. The study purpose was to collate information from Peace Officer Standards and Training (POST) Commission staff in each USA state to document current fitness mandates and policies for recruits/officers. A 10-question survey was allocated to an appropriate representative from every state POST organization. The survey collected information regarding minimum state-mandated fitness standards for academy entry and exit; minimum state-mandated requirements for fitness programming, including safety plans; education/training requirements for fitness training instructors; and minimum …

Novel Electrospinning Techniques For Fabricating Scaffolds To Model Intracranial Atherosclerotic Disease In Tissue Engineered Blood Vessel Mimics, Isaac "Squeaky" Buentipo

Master's Theses

Novel Electrospinning Techniques for Fabricating Scaffolds to Model Intracranial

Atherosclerotic Disease in Tissue Engineered Blood Vessel Mimics

Isaac “Squeaky” Buentipo

Dr. Kristen Cardinal’s Tissue Engineering Lab at California Polytechnic State University specializes in fabricating customized vascular models, known as Blood Vessel Mimics (BVMs), for medical device testing. BVMs are simplified in vitro vascular models designed to bridge the gap between bench testing and in vivo evaluation of intravascular medical devices. BVMs are produced by combining a polymer scaffold with human vascular cells. Through novel scaffold fabrication techniques, such as silicone injection molding, silicone dip casting and electrospinning, the capabilities of …

Evaluation Of Antibiotic Testing Protocols For Biofilm-Forming Escherichia Coli In A Microfluidic Platform, Caleb R. Telander

Master's Theses

Catheter-associated urinary tract infections remain an ongoing clinical problem due to biofilm persistence and antibiotic resistance. Standard antibiotic susceptibility testing cannot accurately reproduce flow conditions and the spatial complexity of the in vivoenvironment and is thus questionable in relevance to device-related infections. This study examines a microfluidic device designed to simulate physiologically relevant wall shear stress and antibiotic gradients in Escherichia coli biofilms. The polydimethylsiloxane-based system integrates a 16-well culture chamber with a gradient generator. Biofilm growth was observed using fluorescence microscopy of green fluorescent protein-labeled bacteria. Simulations performed using COMSOL Multiphysics software estimated the appropriate range of wall …

Personalized Pain Management Pathway Based On Individual Diagnoses, Tiana Bell Asn, Rn, Diana Desmornes Asn, Rn, Autumn Dwyer Bsn, Rn, Monica Foley Asn, Rn, Marissa Forleo Bsn, Rn, Heather Mcmillan Asn, Rn, Nicole Valenti Bsn, Rn

Posters

The intervention we’re proposing offers a comprehensive, individualized approach to pain management, taking into account diagnosis-specific pain scales, nonpharmacological interventions, and continued pain control post-discharge.

United Seas For Resilient Reefs: A Blueprint For Coral Conservation Through International Cooperation, John J. Bohorquez, Maoz Fine, Dana I. Grieco, David A. Gill, Ali Al-Swalimih, Jacqueline Padilla-Gamino, Isaiah W. Bolden, Margaux Hein, Callum Backstrom, Melanie Mcfield, Raphael Martinez, Benjamin Midberry, Fahd Al-Guthmy, Ellen K. Pikitch, Natalia Benejam, Chen Azulay, Britt Ronen, Oren Levy, Anne Mcelroy, Karine Kleinhaus

School of Marine & Atmospheric Sciences Faculty Publications

Coral reefs are one of Earth’s most vital and threatened ecosystems. They protect coastlines, generate billions of dollars of tourism revenue, support valuable fisheries, and contribute to the development of vital medicines. Yet half of the world's coral reefs have been lost in the last 50 years, and 90% of remaining reefs are projected to die off by the middle of this century, mainly due to warming seas from climate change.

Despite these challenges there is reason for hope. Some coral reefs – such as in the northern Red Sea and Gulf of Aqaba – have demonstrated remarkable resilience to …

The Use Of Partial Textual Stimuli Within An Interactive Task For Increasing Reports Of Past Behavior With A Child With Autism, Masyn S. Mcwilliams, Robbie Hanson

Faculty Scholarship

Individuals with autism spectrum disorder (ASD) may face challenges with reporting past behavior. Although some behavior-analytic studies have shown success with increasing these reports, the use of materials within activities that do not repeat has not been assessed (e.g., Shillingsburg et al., 2017). Thus, the purpose of the current study was to expand upon previous research (e.g., Shillingsburg et al. 2017; 2019) by utilizing novel materials within activities completed and examining the use of partial textual stimuli within an interactive task to increase reports of past behavior for one child with autism. The results showed an increase in reports of …