Digital Commons Network^™

Charting The Regulatory Landscape Of Tp53 On Transposable Elements In Cancer, Xuan Qu, Yonghao Liang, Colin Mccornack, Xiaoyun Xing, Heather Schmidt, Chad Tomlinson, Catrina Fronick, Edward A Belter, Juan F Macias-Velasco, Ting Wang

2020-Current year OA Pubs

The relationship between TP53 and transposable elements (TEs) has been obscure. Given the important role of TEs in oncogenesis, a comprehensive profiling of TE expression dynamics under the regulation of TP53 provides valuable resources for more clarity in TP53's roles in cancer. In this study, we characterized the TE transcriptomic landscape using long-read RNA-seq and short-read RNA-seq in three cancer cell lines varying only in

Climatologist Mann's Defamation Suit Victory: Can It Resolve The Crisis Of Expertise, David S. Caudill

Faculty Publications

When a jury awarded one million dollars in punitive damages to climatologist Michael Mann, in his defamation suit against writer Mark Steyn (who accused Mann of scientific fraud), it was newsworthy, even surprising, because opinions regarding scientific matters are rarely actionable. And yet it was not seen as a groundbreaking event in terms of legal doctrine, since the outcome was easily justifiable— Steyn’s accusation was provably false. However, even if the Constitutional contours of defamation law did not change, the Mann verdict has far-reaching implications for a major contemporary social phenomenon, namely the so-called crisis of expertise, a term identifying …

Ocular Phenotyping Of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes, Abraham Hang, Andy Shao, Michael Shea, Michel J Roux, Denise M Imai-Leonard, David J Adams, Takanori Amano, Oana V Amarie, Zorana Berberovic, Raphaël Bour, Lynette Bower, Brian C Leonard, Steve D Brown, Soo Young Cho, Sharon Clementson-Mobbs, Abigail J D'Souza, Mary Dickinson, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe De Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jason Salazar, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Tania Sorg, Michelle Stewart, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Wolfgang Wurst, Atsushi Yoshiki, Hamid Meziane, Glenn Yiu, Paul A Sieving, Louise Lanoue, K C Kent Lloyd, Colin Mckerlie, Ala Moshiri, International Mouse Phenotyping Consortium (Impc)

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Analyze phenotypic data from knockout mice with late-adult retinal pathologic phenotypes to identify genes associated with development of adult-onset retinal diseases.

Methods: The International Mouse Phenotyping Consortium (IMPC) database was queried for genes associated with abnormal retinal phenotypes in the late-adult knockout mouse pipeline (49-80 weeks postnatal age). We identified human orthologs and performed protein-protein analysis and biological pathways analysis with known inherited retinal disease (IRD) and age-related macular degeneration (AMD) genes using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), PLatform for Analysis of single cell Eye in a Disk (PLAE), Protein Analysis Through Evolutionary Relationships (PANTHER), …

The Use Of Biased Language In The Care Of Seriously Ill Children: A Pilot Study, Terri Major-Kincade, Erin Kim, Cameron A Price, Ankona Banerjee, Nikashia Franklin, Israel Castañeda Almendárez, Jaime Jump, Jared Rubenstein, Jill Ann Jarrell

Faculty, Staff and Students Publications

Background

Objective

Setting/Participants

Iron Deficiency Without Anemia And Reduced Basal Ganglia Iron Content In Youths, Dimitri Fiani, Joo-Won Kim, Mianzhi Hu, Ramiro Salas, Sarah Heilbronner, Jacquelyn Powers, Muhammad Haque, Stephanie Dinh, Xiaofan Huang, Darrell Worthy, Sridevi Devaraj, Junqian Xu, Chadi Calarge

Faculty, Staff and Students Publications

Importance: Although brain iron is necessary for neurogenesis, myelination, and neurotransmitter synthesis, iron deficiency (ID) is defined solely based on hematological outcomes.

Objective: To examine the association of ID without anemia with basal ganglia (BG) iron content and its structural and functional sequelae in adolescents.

Design, setting, and participants: This cross-sectional study enrolled participants using the electronic medical record system from a large network of pediatrics clinics between December 2020 and April 2024. Otherwise healthy, unmedicated participants aged 10 to 17 years with a depressive or anxiety disorder or with no psychopathology were consecutively enrolled. Anemia and acute inflammation led …

Accessibility To Public Spaces: Intersections Between The Courts And The Houseless Community, Margaret Maxey

Dissertations and Theses

In an attempt to answer the question of what role the judiciary played in affecting access to public spaces from the 1960's to 2024, this thesis identifies an accumulation of patterns relating to the courts' role in accessibility of public parks and their amenities over this time period. The data supplied for this question is drawn from scholars focusing on judicial decisions and political theory relating to public spaces, including those mentioned above. The result of this study will include a close examination of the role the judiciary holds as a cornerstone institution in not only our democracy, but in …

Present And Future Of Microbiome-Targeting Therapeutics, Lauren E Lynch, Rachel Lahowetz, Christian Maresso, Austen Terwilliger, Jason Pizzini, Valeria Melendez Hebib, Robert A Britton, Anthony W Maresso, Geoffrey A Preidis

Children’s Nutrition Research Center Staff Publications

A large body of evidence suggests that single- and multiple-strain probiotics and synbiotics could have roles in the management of specific gastrointestinal disorders. However, ongoing concerns regarding the quality and heterogeneity of the clinical data, safety in vulnerable populations, and the lack of regulation of products containing live microbes are barriers to widespread clinical use. Safety and regulatory issues must be addressed and new technologies considered. One alternative future strategy is the use of synthetic bacterial communities, defined as manually assembled consortia of two or more bacteria originally derived from the human gastrointestinal tract. Synthetic bacterial communities can model functional, …

Intraosseous Vs Intravenous Access For Epinephrine In Pediatric Out-Of-Hospital Cardiac Arrest, Masashi Okubo, Sho Komukai, Junichi Izawa, Sunhee Chung, Cameron Dezfulian, Francis X Guyette, Joshua R Lupton, Christian Martin-Gill, Sylvia Owusu-Ansah, Sriram Ramgopal, Clifton W Callaway

Faculty, Staff and Students Publications

Importance: While epinephrine is commonly administered in children with out-of-hospital cardiac arrest (OHCA) via an intraosseous (IO) or intravenous (IV) route, the optimal route of epinephrine delivery is unclear.

Objective: To evaluate the association between the route of epinephrine administration (IO or IV) and patient outcomes after pediatric OHCA.

Design, setting, and participants: Retrospective cohort study of pediatric patients (aged < 18 years) with nontraumatic OHCA treated by emergency medical services who received prehospital epinephrine either via an IO or IV route. Patients were included in the Resuscitation Outcomes Consortium Epidemiologic Registry, a prospective OHCA registry at 10 sites in the US and Canada from April 2011 to June 2015. Data analysis was performed from May 2024 to April 2025.

Exposure: Epinephrine administration route: IO or IV route.

Main outcomes and measures: The primary outcome was survival to hospital discharge. The secondary outcome was return of spontaneous circulation (ROSC) before hospital arrival. Propensity scores were calculated and inverse probability of …

Dominant Interfering Card11 Variants Disrupt Jnk Signaling To Promote Gata3 Expression In T Cells, Bradly M Bauman, Jeffrey R Stinson, Melissa A Kallarakal, Lei Haley Huang, Andrew M Frank, Gauthaman Sukumar, Nermina Saucier, Clifton L Dalgard, Alice Y Chan, Joshua D Milner, Megan A Cooper, Andrew L Snow

2020-Current year OA Pubs

Several "primary atopic disorders" are linked to monogenic defects that attenuate TCR signaling, favoring T helper type 2 (TH2) cell differentiation. Patients with CARD11-associated atopy with dominant interference of NF-κB signaling (CADINS) disease suffer from severe atopy, caused by germline loss-of-function/dominant interfering (LOF/DI) CARD11 variants. The CARD11 scaffold enables TCR-induced activation of NF-κB, mTORC1, and JNK signaling, yet the function of CARD11-dependent JNK signaling in T cells remains nebulous. Here we show that CARD11 is critical for TCR-induced activation of JNK1 and JNK2, as well as canonical JUN/FOS AP-1 family members. Patient-derived CARD11 DI variants attenuated WT CARD11 JNK signaling, …

Is Ride-Hailing A Potential Solution For Older Adults After Driving Cessation? The Role Of Objective And Perceived Accessibility, Minju Kim Song

Dissertations and Theses

Due to age-related physical and cognitive changes, older drivers have a greater risk of crashes and are restricted by age-dependent regulation. Nonetheless, many older adults in the United States maintain a car-dependent lifestyle and still prefer driving. When driving cessation or reduction becomes necessary, a primary concern is finding suitable alternative transportation modes. However, the availability of alternative transportation modes does not guarantee their actual use of these options.

As a relatively new transportation mode, ride-hailing services, such as Uber and Lyft, offer on-demand, door-to-door transportation and may be a feasible transportation solution for older adults who stop driving. While …

Evaluation Of Social Worker Knowledge Of Human Trafficking At The Oregon State Hospital: A Qualitative And Quantitative Analysis Of Education, Training, And Victim Identification, Jamie Sue Pryde

Dissertations and Theses

The prevalence of human trafficking continues to increase worldwide, and the implementation of human trafficking education and victim identification within institutions is slow to catch up. The Oregon State Hospital is a psychiatric in-patient hospital that currently does not provide human trafficking education or a screening tool for staff and does not know how to provide treatment to trafficked victims. Interviews were conducted with employed social workers at the Oregon State Hospital to obtain a baseline understanding of their previous education, training, and knowledge of human trafficking to aid in the creation of a trafficking screening tool. Results indicate participants …

The Aga Khan Health Services

University press releases and calendars

No abstract provided.

Aku Original Artwork, Aku Seals

Old name/logo items (letterheads, seals, posters, etc.)

No abstract provided.

Adaptive Reuse Of The Interior Design Of Heritage Buildings As Museums (Analytical Study Of Aisha Fahmy Palace, Cairo-Egypt), Nada Ahmed Arisha

Journal of Art, Design and Music

Heritage buildings convey the history of place and time, it maintains and preserves the different identities in which the building is built for. Adaptive reuse is the process of sustaining the Architecture and Interior design of the heritage building to protect, sustain and extend the age of the building and defending it from demolishing. The research illustrates the Adaptive reuse in heritage buildings which became museums after adaptation and restoration processes including mass addition and extension processes. A case study is mentioned including Aisha Fahmy Palace, which was site visited by the researcher to reveal the adaptation and restoration processes …

Proposing An Integrative Framework For Conducting Empirical Research On Culture-Inspired Product Design, Peter Oluwagbenga Odewole, Michael Abiodun Oyinloye, Johnson Olarinde Oladesu

Journal of Art, Design and Music

In developing African countries, such as Nigeria, the intersection of culture and product design poses a multifaceted challenge that demands comprehensive investigation. The existing body of research needs an integrative framework that adequately addresses the intricate dynamics involved in culture-inclined product design processes within these specific socio-economic and cultural contexts. This deficiency hampers the ability of designers, researchers, and policymakers to develop effective strategies for creating products that resonate with their diverse cultural heritage. Using a qualitative research method based on secondary data, this study develops an integrative framework for conducting empirical research on culture-inspired product design focusing on Nigeria, …

Survey On Seed Biology And Pharmacological Properties Of Four Important Species, Mohamad Hesam Shahrajabian, Wenli Sun

Bulletin of Faculty of Pharmacy Cairo University

Medicinal and aromatic plants are gaining more importance because of their potential application in food, pharmaceutical and fragrance industry. Medicinal and aromatic plants have been used in cosmetics, perfumery, pharmaceuticals and food flavoring since ancient times, because of the presence of essential oils and different components. Seeds are of immense economic and biological importance, and they contain high oil, protein and starch reserves. The seeds of medicinal and aromatic plants are stores of important and active secondary metabolites that have been economically and commercially beneficial and helpful for medicine and pharmacy. The seeds of fennel are highly nutritious, and the …

Michigan Ophthalmology Pathway Program: Five Years Of Aiming To Increase Diversity In Ophthalmology, Keith D. Miller, Karthik Reddy, Anna Kay, Mickey Nguyen, Rafik Issa, Lena Juratli, Mikaelah Johnson Griggs, Mana Yacim, Alan Sugar, Ariane Kaplan

Journal of Academic Ophthalmology

Introduction: Ophthalmology is one of the least diverse medical subspecialties. The Michigan Ophthalmology Pathway (MOP) Program was created at the University of Michigan Medical School in 2017 to promote diversity in ophthalmology through early exposure and longitudinal mentorship for medical students from underrepresented backgrounds (URiM). This innovative institution-level model aimed to increase URiM student interest in ophthalmology and help URiM students develop competitive residency applications. Methods: Each year, first-year medical students (M1) and residents (PGY2) were invited to apply to MOP. MOP mentees were matched one-to-one with an ophthalmology resident mentor whom they shadowed for six days in the clinic …

A Descriptive Analysis Of The Current State Of Peace Officer Standards And Training Physical Fitness Requirements Across The Usa, Robert G. Lockie, Joseph Dulla

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 543-560, 2025. Many law enforcement organizations are experiencing recruitment and retention challenges, of which physical fitness can be a factor. The study purpose was to collate information from Peace Officer Standards and Training (POST) Commission staff in each USA state to document current fitness mandates and policies for recruits/officers. A 10-question survey was allocated to an appropriate representative from every state POST organization. The survey collected information regarding minimum state-mandated fitness standards for academy entry and exit; minimum state-mandated requirements for fitness programming, including safety plans; education/training requirements for fitness training instructors; and minimum …

Novel Electrospinning Techniques For Fabricating Scaffolds To Model Intracranial Atherosclerotic Disease In Tissue Engineered Blood Vessel Mimics, Isaac "Squeaky" Buentipo

Master's Theses

Novel Electrospinning Techniques for Fabricating Scaffolds to Model Intracranial

Atherosclerotic Disease in Tissue Engineered Blood Vessel Mimics

Isaac “Squeaky” Buentipo

Dr. Kristen Cardinal’s Tissue Engineering Lab at California Polytechnic State University specializes in fabricating customized vascular models, known as Blood Vessel Mimics (BVMs), for medical device testing. BVMs are simplified in vitro vascular models designed to bridge the gap between bench testing and in vivo evaluation of intravascular medical devices. BVMs are produced by combining a polymer scaffold with human vascular cells. Through novel scaffold fabrication techniques, such as silicone injection molding, silicone dip casting and electrospinning, the capabilities of …

Evaluation Of Antibiotic Testing Protocols For Biofilm-Forming Escherichia Coli In A Microfluidic Platform, Caleb R. Telander

Master's Theses

Catheter-associated urinary tract infections remain an ongoing clinical problem due to biofilm persistence and antibiotic resistance. Standard antibiotic susceptibility testing cannot accurately reproduce flow conditions and the spatial complexity of the in vivoenvironment and is thus questionable in relevance to device-related infections. This study examines a microfluidic device designed to simulate physiologically relevant wall shear stress and antibiotic gradients in Escherichia coli biofilms. The polydimethylsiloxane-based system integrates a 16-well culture chamber with a gradient generator. Biofilm growth was observed using fluorescence microscopy of green fluorescent protein-labeled bacteria. Simulations performed using COMSOL Multiphysics software estimated the appropriate range of wall …

Personalized Pain Management Pathway Based On Individual Diagnoses, Tiana Bell Asn, Rn, Diana Desmornes Asn, Rn, Autumn Dwyer Bsn, Rn, Monica Foley Asn, Rn, Marissa Forleo Bsn, Rn, Heather Mcmillan Asn, Rn, Nicole Valenti Bsn, Rn

Posters

The intervention we’re proposing offers a comprehensive, individualized approach to pain management, taking into account diagnosis-specific pain scales, nonpharmacological interventions, and continued pain control post-discharge.

United Seas For Resilient Reefs: A Blueprint For Coral Conservation Through International Cooperation, John J. Bohorquez, Maoz Fine, Dana I. Grieco, David A. Gill, Ali Al-Swalimih, Jacqueline Padilla-Gamino, Isaiah W. Bolden, Margaux Hein, Callum Backstrom, Melanie Mcfield, Raphael Martinez, Benjamin Midberry, Fahd Al-Guthmy, Ellen K. Pikitch, Natalia Benejam, Chen Azulay, Britt Ronen, Oren Levy, Anne Mcelroy, Karine Kleinhaus

School of Marine & Atmospheric Sciences Faculty Publications

Coral reefs are one of Earth’s most vital and threatened ecosystems. They protect coastlines, generate billions of dollars of tourism revenue, support valuable fisheries, and contribute to the development of vital medicines. Yet half of the world's coral reefs have been lost in the last 50 years, and 90% of remaining reefs are projected to die off by the middle of this century, mainly due to warming seas from climate change.

Despite these challenges there is reason for hope. Some coral reefs – such as in the northern Red Sea and Gulf of Aqaba – have demonstrated remarkable resilience to …

The Use Of Partial Textual Stimuli Within An Interactive Task For Increasing Reports Of Past Behavior With A Child With Autism, Masyn S. Mcwilliams, Robbie Hanson

Faculty Scholarship

Individuals with autism spectrum disorder (ASD) may face challenges with reporting past behavior. Although some behavior-analytic studies have shown success with increasing these reports, the use of materials within activities that do not repeat has not been assessed (e.g., Shillingsburg et al., 2017). Thus, the purpose of the current study was to expand upon previous research (e.g., Shillingsburg et al. 2017; 2019) by utilizing novel materials within activities completed and examining the use of partial textual stimuli within an interactive task to increase reports of past behavior for one child with autism. The results showed an increase in reports of …

Cip Final Impact Report, Center For Innovative Pedagogy

Annual Reports and Newsletters

No abstract provided.

Microplastic Eaters, Alanna Boze

Bioengineering Senior Theses

This thesis evaluated Alcanivorax Borkumensis’ (A. Borkumensis) ability to degrade polystyrene in a pyruvate-rich environment to determine if the bacteria could degrade the microplastic when grown in pyruvate. The thesis explored the metabolic behavior of A. Borkumensis when pyruvate is used to start the gluconeogenesis pathway, which is the start of the metabolic pathway when degradation occurs. The bacterium was grown in ONR7a medium, that was adjusted to a pH of 8.1, and 1% pyruvate; then it was processed by centrifugation and washing before experimentation began. Trials were conducted to iteratively refine the process and verify trial results. Bacterial growth …

Ai-Based Requirements Analysis Assistant That Applies Explicit Knowledge And Includes Humans In The Loop, Steven Alter

Business Analytics and Information Systems

This exploratory paper builds on the EMMSAD 2024 paper “Could a Large Language Model Contribute Significantly to Requirements Analysis?” Eight versions of each of three LLM prompts (for system structure, analysis, and recommendations) were applied to three 3000+ word case studies. Those versions expressed different “treatments” including a control with no RAG augmentation, a version with RAG augmentation based on an analysis template used by MBA and EMBA students, and six other versions based on theoretical approaches such as activity theory, a BPM design space, work system principles, and so on. The LLM responses were somewhat reliable for summarizing system …

The Evolvement Of The 100 Most Cited Articles In Spine Surgery In The Last Decade Compared To All-Time, Mark Miller, Matthew Meade, Ruchir Nanavati, William T Diciurcio, Maneesha Palakurthi, Adam Kohring, Justin Le, Christopher Giuditta, Christopher Kepler, Barrett Woods

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Decision-making in spine surgery is continuously shaped by advancements in the field through evidence-based medicine. This is demonstrated through the evolution of the quality and impact of scientific research within the field of spine surgery. To date, there is limited literature investigating interval changes in methodological rigor of scientific investigation within the field of spine surgery.

METHODS: The top 100 cited articles were recorded for manuscripts from January 1, 2013, to December 31, 2023, and the top 100 most cited manuscripts of all time for spine surgery, via the Scopus abstract and citation database. Data collected included year of …

Effect Of Foot Strike Pattern On Joint Kinetics On A Downhill Slope, Evan Manley

Master's Theses

With recent increases in participation in outdoor running events, there is a need for research in downhill gait biomechanics. One change that could impact joint loading is foot strike pattern. Foot strike patterns have been categorized into rearfoot-strike (RFS), midfoot-strike (MFS), and forefoot-strike (FFS) [1]. While 75-99% of distance runners naturally RFS on level surfaces, they tend to move towards FFS when it is necessary to reduce vertical loading conditions at the knee [1]. The purpose of this study was to examine differences in peak vertical knee and ankle forces, knee moment, and ankle power, as well as cumulative force …

Balance Assessment Of Disc Golf Players By A Smartphone, Joshua Paul Kannankunni

Master's Theses

Disc golf is an underrepresented sport in biomechanics research, even though it could have effects on gait and balance. Forward and side lunges performed while throwing discs can improve static and dynamic balance. The purpose of this study was to explore the effects of playing disc golf on various static and dynamic balance metrics. Static and dynamic balance experiments were done on 20 disc golf players and 20 control participants to record their RMS of acceleration during the double leg, tandem, and single leg static poses, as well as their gait speed, cadence, stride length, right step length, left step …

Black Faculty And Staff Association Newsletter. Issue 3 (2025), Nashieli Marcono

Black Faculty and Staff Association

Table of Contents

• Greetings from the President! - Dr. Bronwen Forbay
• 2nd Year@Furman: Dr. Geniece Crawford-Mondé (Sociology)
• Spotlight: Daniel Fernandez (Furman University Libraries)
• A Year in Photos
• Where in the World is Roger? A Catch-Up with Dr. Roger Sneed (Religion)
• The Souls of BFSA: A Reflection Alexis Carter Thomas, Associate Chaplain
• Dr. Shaniece Criss: An Interview
• Farewell Wishes